Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| expedited partner therapy to combat neisseria gonorrhoeae and chlamydia trachomatis in military populations: can we apply this best practice? | expedited partner therapy (ept) is the practice of treating the partners of patients with sexually transmitted infections by providing medications for the patient to deliver to his or her sexual partner (s) without direct clinical assessment of the partner(s). ept is an evidence-based option that can augment existing partner management strategies. for military health care providers, questions still loom as to the pragmatic medical, legal, and ethical uncertainties of ept use in military populati ... | 2015 | 26226530 |
| contextual factors surrounding anal intercourse in women: implications for sexually transmitted infection/hiv prevention. | our objectives were to describe women's reasons for engaging in anal intercourse (ai), contextual factors surrounding ai, and how these vary by current rectal sexually transmitted infection (sti) status, and to assess women's knowledge and concerns about rectal infections. | 2015 | 26222748 |
| treatment of cases of neisseria gonorrhoeae and chlamydia trachomatis in emergency department patients. | the aim of this study was to determine the proportion of patients treated appropriately, both presumptively in the emergency department (ed), and at follow-up, among those patients who ultimately tested positive for either neisseria gonorrhoeae (ng) or chlamydia trachomatis (ct). secondary aims were to characterize patients who received appropriate presumptive antibiotic treatment of both ng and ct at the time of ed visit and to compare them to patients who did not receive appropriate presumptiv ... | 2015 | 26222746 |
| rare events of intragenus and intraspecies horizontal transfer of the 16s rrna gene. | horizontal gene transfer (hgt) of operational genes has been widely reported in prokaryotic organisms. however, informational genes such as those involved in transcription and translation processes are very difficult to be horizontally transferred, as described by woese's complexity hypothesis. here, we analyzed all of the completed prokaryotic genome sequences (2,143 genomes) in the ncbi (national center for biotechnology information) database, scanned for genomes with high intragenomic heterog ... | 2015 | 26220935 |
| a chlamydia effector recruits cep170 to reprogram host microtubule organization. | the obligate intracellular bacterial pathogen chlamydia trachomatis deploys virulence effectors to subvert host cell functions enabling its replication within a specialized membrane-bound compartment termed an inclusion. the control of the host cytoskeleton is crucial for chlamydia uptake, inclusion biogenesis and cell exit. here, we demonstrate how a chlamydia effector rearranges the microtubule (mt) network by initiating organization of the mts at the inclusion surface. we identified an inclus ... | 2015 | 26220855 |
| management of non-gonococcal urethritis. | non-gonococcal urethritis (ngu), or inflammation of the urethra, is the most common treatable sexually transmitted syndrome in men, with approximately 20-50 % of cases being due to infection with chlamydia trachomatis and 10-30 % mycoplasma genitalium. other causes are ureaplasma urealyticum, trichomonas vaginalis, anaerobes, herpes simplex virus (hsv) and adenovirus. up to half of the cases are non-specific. urethritis is characterized by discharge, dysuria and/or urethral discomfort but may be ... | 2015 | 26220178 |
| treatment challenges for urogenital and anorectal chlamydia trachomatis. | while true antimicrobial resistance to chlamydia trachomatis is a rare occurrence, repeat chlamydia infections continue to be reported following treatment with a single 1 g dose of azithromycin or week long doxycycline - with considerable more concern about azithromycin treatment failure. while most repeat positive cases are likely to be reinfections, emerging evidence indicates treatment failure may play a role. current data suggests that there may are differences in the efficacy of the drugs b ... | 2015 | 26220080 |
| chlamydia trachomatis type iii secretion proteins regulate transcription. | the scc4 protein (ct663) of the pathogenic bacterium chlamydia has been described as a type iii secretion (t3s) chaperone as well as an inhibitor of rna polymerase. to examine if these roles are connected, we first investigated physical interactions between chlamydia trachomatis scc4 and the t3s chaperone scc1 and a t3s substrate, copn. in a yeast 3-hybrid assay, scc4, scc1, and copn were all required to detect an interaction, which suggests that these proteins form a trimolecular complex. we al ... | 2015 | 26216849 |
| comparable genital tract infection, pathology, and immunity in rhesus macaques inoculated with wild-type or plasmid-deficient chlamydia trachomatis serovar d. | rhesus macaques were studied to directly address the potential for plasmid-deficient chlamydia trachomatis to serve as a live attenuated vaccine in the genital tract. five repeated cervical inoculations of rhesus macaques with wild-type serovar d strain d/uw-3/cx or a plasmid-deficient derivative of this strain, ctd153, resulted in infections with similar kinetics and induced comparable levels of protective immunity. after all animals received five challenges with d/uw-3/cx, levels of inflammati ... | 2015 | 26216426 |
| chlamydia trachomatis infection in young adults - association with concurrent partnerships and short gap length between partners. | sexually transmitted infections (stis) continue to be highly prevalent in young people. new understanding of sexual risk behaviour is essential for future preventive initiatives. studies based on self-reported sti history indicate that gap length between sexual partnerships is an important determinant in sti transmission, but little is known about the impact of concurrent partnerships and short gap length. this study aimed to examine the significance of concurrent partnerships and short gap leng ... | 2015 | 26211606 |
| intraamniotic inflammation in women with preterm prelabor rupture of membranes. | to characterize subgroups of preterm prelabor rupture of membranes (pprom) and short-term neonatal outcomes based on the presence and absence of intraamniotic inflammation (iai) and/or microbial invasion of the amniotic cavity (miac). | 2015 | 26208287 |
| dna microarray characterization of pathogens associated with sexually transmitted diseases. | this study established a multiplex pcr-based microarray to detect simultaneously a diverse panel of 17 sexually transmitted diseases (stds)-associated pathogens including neisseria gonorrhoeae, chlamydia trachomatis, mycoplasma genitalium, mycoplasma hominis, ureaplasma, herpes simplex virus (hsv) types 1 and 2, and human papillomavirus (hpv) types 6, 11, 16, 18, 31, 33, 35, 39, 54 and 58. the target genes are 16s rrna gene for n. gonorrhoeae, m. genitalium, m. hominism, and ureaplasma, the majo ... | 2015 | 26208181 |
| chlamydia trachomatis in vivo to in vitro transition reveals mechanisms of phase variation and down-regulation of virulence factors. | research on the obligate intracellular bacterium chlamydia trachomatis demands culture in cell-lines, but the adaptive process behind the in vivo to in vitro transition is not understood. we assessed the genomic and transcriptomic dynamics underlying c. trachomatis in vitro adaptation of strains representing the three disease groups (ocular, epithelial-genital and lymphogranuloma venereum) propagated in epithelial cells over multiple passages. we found genetic features potentially underlying pha ... | 2015 | 26207372 |
| design, synthesis and evaluation of novel polypharmacological antichlamydial agents. | discovery of new polypharmacological antibacterial agents with multiple modes of actions can be an alternative to combination therapy and also a possibility to slow development of antibiotic resistance. in support to this hypothesis, we synthesized 16 compounds by combining the pharmacophores of chlamydia trachomatis inhibitors and inhibitors of type iii secretion (t3s) in gram-negative bacteria. in this study we have developed salicylidene acylhydrazide sulfonamides (11c &11d) as new antichlamy ... | 2015 | 26204507 |
| human papillomavirus in young women with chlamydia trachomatis infection 7 years after the australian human papillomavirus vaccination programme: a cross-sectional study. | the national quadrivalent human papillomavirus (4vhpv) vaccination programme was launched in australia in april, 2007. in this study, we aimed to explore the prevalence of vaccine-targeted human papillomavirus (hpv) types contained in the 4vhpv and nine-valent hpv (9vhpv) vaccines detected in young women diagnosed with chlamydia. | 2015 | 26201300 |
| large two-centre study into the prevalence of mycoplasma genitalium and trichomonas vaginalis in the netherlands. | mycoplasma genitalium and trichomonas vaginalis are common sexually transmitted infections (stis). in the netherlands, testing for m. genitalium and t. vaginalis is not recommended for first-line sti screening. recent reports about the increasing antimicrobial resistance in m. genitalium raise concern about the adequacy of current empirical treatment regimens. it is necessary to have insight in the prevalence of m. genitalium and t. vaginalis in order to evaluate current first-line sti screening ... | 2016 | 26199286 |
| chlamydia trachomatis scavenges host fatty acids for phospholipid synthesis via an acyl-acyl carrier protein synthetase. | the obligate intracellular parasite chlamydia trachomatis has a reduced genome but relies on de novo fatty acid and phospholipid biosynthesis to produce its membrane phospholipids. lipidomic analyses showed that 8% of the phospholipid molecular species synthesized by c. trachomatis contained oleic acid, an abundant host fatty acid that cannot be made by the bacterium. mass tracing experiments showed that isotopically labeled palmitic, myristic, and lauric acids added to the medium were incorpora ... | 2015 | 26195634 |
| chlamydia trachomatis, neisseria gonorrhoeae and syphilis among men who have sex with men in brazil. | sexually transmitted diseases (std) are frequently asymptomatic and increase the likelihood of transmitting and acquiring hiv. in brazil, the guidelines for stds diagnosis and treatment are based on the syndromic approach. nucleic acid amplification tests (naat) has been recommended as routine stds screening in some countries, especially for men who have sex with men (msm). limited data are available about how to best define target groups for routine screening by naats within this population. we ... | 2015 | 26195002 |
| incidence and persistence of carcinogenic genital human papillomavirus infections in young women with or without chlamydia trachomatis co-infection. | we assessed whether infection with chlamydia increases the incidence of carcinogenic human papillomavirus (hpv) infections and if hpv persistence is affected by chlamydia co-infection. for 1982 women (16-29 years-old) participating in two consecutive rounds of a chlamydia screening implementation trial, swabs were polymerase chain reaction tested to detect chlamydia and 14 carcinogenic hpv genotypes. hpv type-specific incidence and persistence rates were stratified for chlamydia positivity at fo ... | 2015 | 26194784 |
| an excess of the proinflammatory cytokines ifn-γ and il-12 impairs the development of the memory cd8+ t cell response to chlamydia trachomatis. | the obligate intracellular bacterium chlamydia trachomatis is the most common cause of bacterial sexually transmitted disease in the united states and the leading cause of preventable blindness worldwide. transfer of cultured chlamydia-specific cd8(+) t cells or vaccination with recombinant virus expressing an mhc i-restricted chlamydia ag confers protection, yet surprisingly a protective cd8(+) t cell response is not stimulated following natural infection. in this study, we demonstrate that the ... | 2015 | 26179901 |
| hypothetical protein ct398 (cdsz) interacts with σ(54) (rpon)-holoenzyme and the type iii secretion export apparatus in chlamydia trachomatis. | a significant challenge to bacteriology is the relatively large proportion of proteins that lack sufficient sequence similarity to support functional annotation (i.e. hypothetical proteins). the aim of this study was to apply protein structural homology to gain insights into a candidate protein of unknown function (ct398) within the medically important, obligate intracellular bacterium chlamydia trachomatis. c. trachomatis is a major human pathogen responsible for numerous infections throughout ... | 2015 | 26173998 |
| optimized testing for c. trachomatis dna in synovial fluid samples in clinical practice. | no standardized polymerase chain reaction (pcr) assay is available for detection of chlamydia trachomatis (c. tr.) in synovial fluid (sf) for diagnostic use in clinical practice. this study tested the performance of two optimized molecular biology methods, to determine which is best suited for detecting c. tr. in sf clinical samples from patients with various rheumatologic diseases. | 2015 | 26169749 |
| chlamydia trachomatis testing among young people: what is the role of stigma? | to reach young people for chlamydia trachomatis (ct) testing, new web-based strategies are used to offer testing via young people's sexual and social networks. the success of such peer-driven strategies depends on whether individuals disclose their own testing and encourage others to get tested. we assessed whether public- and self-stigma would hamper these behaviours, by comparing anticipations and experiences relating to these issues in young men and women who already tested or never tested fo ... | 2015 | 26169173 |
| [improving the diagnosis of chlamydia trachomatis infections in the molecular era, an opportunity for surveillance programs]. | 2015 | 26166475 | |
| rectal lymphogranuloma venereum in hiv-infected patients can mimic lymphoma. | an outbreak of rectal lymphogranuloma venereum (lgv) has been reported since 2003 in men who have sex with men, most of them being infected with human immunodeficiency virus. in these patients, unusual clinical presentations such as rectal tumor or intense lymphoproliferation on rectal biopsies may lead to an erroneous diagnosis of aggressive non-hodgkin lymphoma. three patients were referred to our center for the management of rectal b-cell non-hodgkin lymphoma on the basis of a rectal patholog ... | 2017 | 26166139 |
| prevalence and correlates of chlamydia trachomatis and neisseria gonorrhoeae by anatomic site among urban thai men who have sex with men. | chlamydia trachomatis (ct) and neisseria gonorrhoeae (ng) infection are prevalent among men who have sex with men (msm) and may infect multiple anatomic sites. we measured site-specific prevalence and correlates of ct and ng infection among bangkok msm cohort study participants. | 2015 | 26165436 |
| management of pelvic inflammatory disease in selected u.s. sexually transmitted disease clinics: sexually transmitted disease surveillance network, january 2010-december 2011. | pelvic inflammatory disease (pid) remains an important source of preventable reproductive morbidity, but no recent studies have singularly focused on us sexually transmitted disease (std) clinics in relationship to established guidelines for diagnosis and treatment. | 2015 | 26165434 |
| the late endocytic rab39a gtpase regulates the interaction between multivesicular bodies and chlamydial inclusions. | given their obligate intracellular lifestyle, chlamydia trachomatis ensure that they have access to multiple host sources of essential lipids by interfering with vesicular transport. these bacteria hijack rab6-, rab11- and rab14-controlled trafficking pathways to acquire sphingomyelin from the golgi complex. another important source of sphingolipids, phospholipids and cholesterol are multivesicular bodies (mvbs). despite their participation in chlamydial inclusion development and bacterial repli ... | 2015 | 26163492 |
| human papillomavirus positivity in women undergoing intrauterine insemination has a negative effect on pregnancy rates. | sexually transmitted infections are a major cause of infertility. human papillomavirus (hpv) infection is one of the most common viral infections of the female genital tract. only a limited number of studies have investigated the influence of hpv on fertility and its impact remains controversial. | 2016 | 26160018 |
| population-based study of trachoma in guatemala. | a prevalence survey for active trachoma in children aged under 10 years and trichiasis in women aged 40 years and older was carried out in four districts in the sololá region in guatemala, which is suspected of still having a trachoma problem. | 2015 | 26158582 |
| risk of infection with chlamydia trachomatis from migrants to communities undergoing mass drug administration for trachoma control. | to determine the risk of infection with chlamydia trachomatis in children who are migrants to communities who are undergoing mass drug administration (mda), and if their neighborhoods have higher rates of infection over time. | 2015 | 26158574 |
| screening for asymptomatic lymphogranuloma venereum co-infection in men who have sex with men newly diagnosed with hiv, hepatitis c or syphilis. | patients diagnosed with lymphogranuloma venereum have high rates of co-infection with hiv, syphilis and hepatitis c. the aim of this enhanced surveillance was to screen all men who have sex with men (msm) newly diagnosed with hiv, syphilis or hepatitis c for co-infection with asymptomatic lymphogranuloma venereum as part of the recommended sexual health screen. of the 145 patients screened, 21 patients were diagnosed with rectal chlamydia trachomatis, one with both rectal and urethral chlamydia ... | 2016 | 26158451 |
| a misleading false-negative result using neisseria gonorrhoeae opa mgb multiplex pcr assay in patient's rectal sample due to partial mutations of the opa gene. | a 53-year-old homosexual man presented at his general practitioner (gp) practice with a suspicion of sexually transmitted infection. initial naat screening was performed for chlamydia trachomatis and neisseria gonorrhoeae. the patient was positive for neisseria gonorrhoeae both for his urine and rectal sample. the subsequent confirmation test for neisseria gonorrhoeae by a second laboratory was only confirmed for the urine sample and the rectal sample was negative. we report a case of a potentia ... | 2015 | 26147143 |
| diagnostic accuracy of rapid tests for sexually transmitted infections in symptomatic women. | to determine the diagnostic accuracy of tests developed for use at the point of care for chlamydia trachomatis (ct), neisseria gonorrhoeae (ng) and syphilis in women having symptoms of lower urinary tract infection. | 2016 | 26136508 |
| bioinformatic analysis of chlamydia trachomatis polymorphic membrane proteins pmpe, pmpf, pmpg and pmph as potential vaccine antigens. | chlamydia trachomatis is the most important infectious cause of infertility in women with important implications in public health and for which a vaccine is urgently needed. recent immunoproteomic vaccine studies found that four polymorphic membrane proteins (pmpe, pmpf, pmpg and pmph) are immunodominant, recognized by various mhc class ii haplotypes and protective in mouse models. in the present study, we aimed to evaluate genetic and protein features of pmps (focusing on the n-terminal 600 ami ... | 2015 | 26131720 |
| the clinical management and outcome of term premature rupture of membrane in east china: results from a retrospective multicenter study. | in this study, we investigated the management of term premature rupture of membranes (prom) and maternal-fetal outcomes in east china. between january and december 2012, the term delivery data for 111390 pregnant women was retrospectively analyzed. the subjects were divided into two groups: those women who had term prom (prom group, n=13927) and those who did not (control group, n=94341). the general patient characteristics, the mode of delivery, and the maternal and fetal complications were rec ... | 2015 | 26131227 |
| rna biosignatures in adolescent patients in a pediatric emergency department with pelvic inflammatory disease. | adolescents are at high risk for pelvic inflammatory disease (pid). because accurate diagnosis of pid is difficult, and complications of untreated pid are significant, novel methods to improve diagnosis are essential. | 2015 | 26125533 |
| overtreatment of gonorrhea and chlamydial infections in 2 inner-city emergency departments. | infections with neisseria gonorrhoeae (gc) and chlamydia trachomatis (ct) are the most commonly reported sexually transmitted diseases in the united states. | 2015 | 26119905 |
| global mapping of the inc-human interactome reveals that retromer restricts chlamydia infection. | chlamydia trachomatis is a leading cause of genital and ocular infections for which no vaccine exists. upon entry into host cells, c. trachomatis resides within a membrane-bound compartment—the inclusion—and secretes inclusion membrane proteins (incs) that are thought to modulate the host-bacterium interface. to expand our understanding of inc function(s), we subjected putative c. trachomatis incs to affinity purification-mass spectroscopy (ap-ms). we identified inc-human interactions for 38/58 ... | 2015 | 26118995 |
| rate of repeat diagnoses in men who have sex with men for chlamydia trachomatis and neisseria gonorrhoeae: a retrospective cohort study. | background sexually transmissible infections (stis) have increased rapidly among men who have sex with men (msm). one of the most effective strategies to control stis is partner notification. inadequate partner notification may be associated with high rates of repeat diagnoses with stis. the aim of this study is to estimate and compare the rate of chlamydia and gonorrhoea infection following primary infection to the overall clinic rate. | 2015 | 26117082 |
| chlamydia trachomatis virulence factor ct135 is stable in vivo but highly polymorphic in vitro. | chlamydia trachomatis is an important human pathogen causing both ocular and sexually transmitted disease. recently, we identified ct135 as an important virulence determinant in a mouse infection model. results from cel 1 digestion assays and sequencing analyses indicated that ct135 was much more polymorphic in high in vitro passage reference serovars than it was in clinical strains that had undergone limited passaging. herein, we used targeted next-generation sequencing of the ct134-135 locus, ... | 2015 | 26109550 |
| evaluation of copan floqswab for the molecular detection of chlamydia trachomatis by abbott realtime ct pcr. | we evaluated copan floqswabs next to abbott swabs for the detection of chlamydia trachomatis (ct) by abbott realtime pcr. | 2015 | 26107497 |
| chlamydia trachomatis infection may increase the risk of preeclampsia. | although the etiology of preeclampsia is not well understood, it has been suggested that excessive systemic inflammation may lead to oxidative stress, promoting the endothelial dysfunction characteristic of preeclampsia. few prospective studies have examined the role of infection, an immune system stimulator, as a risk factor for preeclampsia. | 2013 | 26105737 |
| porcine retinal cell line vido r1 and chlamydia suis to modelize ocular chlamydiosis. | human ocular chlamydia trachomatis infections can lead to trachoma, the major cause of infectious blindness worldwide. trachoma control strategies are very helpful but logistically challenging, and a trachoma vaccine is needed but not available. pigs are a valuable large animal model for various immunological questions and could facilitate the study of human ocular chlamydial infections. in addition, a recent study identified the zoonotic potential of chlamydia suis, the natural pathogen of pigs ... | 2015 | 26103808 |
| risk-based screening for chlamydia trachomatis and neisseria gonorrhoeae prior to intrauterine device insertion. | the objective was to compare three strategies for chlamydia trachomatis and neisseria gonorrhoeae screening prior to intrauterine device (iud) insertion. | 2015 | 26093189 |
| vaccines. a mucosal vaccine against chlamydia trachomatis generates two waves of protective memory t cells. | genital chlamydia trachomatis (ct) infection induces protective immunity that depends on interferon-γ-producing cd4 t cells. by contrast, we report that mucosal exposure to ultraviolet light (uv)-inactivated ct (uv-ct) generated regulatory t cells that exacerbated subsequent ct infection. we show that mucosal immunization with uv-ct complexed with charge-switching synthetic adjuvant particles (csaps) elicited long-lived protection in conventional and humanized mice. uv-ct-csap targeted immunogen ... | 2015 | 26089520 |
| a phase 2 trial of oral solithromycin 1200 mg or 1000 mg as single-dose oral therapy for uncomplicated gonorrhea. | progressive resistance to antimicrobial agents has reduced options for gonorrhea therapy worldwide. solithromycin (cem-101) is a novel oral fluoroketolide antimicrobial with substantial in vitro activity against neisseria gonorrhoeae. | 2015 | 26089222 |
| direct measurement of the radical translocation distance in the class i ribonucleotide reductase from chlamydia trachomatis. | ribonucleotide reductases (rnrs) catalyze conversion of ribonucleotides to deoxyribonucleotides in all organisms via a free-radical mechanism that is essentially conserved. in class i rnrs, the reaction is initiated and terminated by radical translocation (rt) between the α and β subunits. in the class ic rnr from chlamydia trachomatis (ct rnr), the initiating event converts the active s = 1 mn(iv)/fe(iii) cofactor to the s = 1/2 mn(iii)/fe(iii) "rt-product" form in the β subunit and generates a ... | 2015 | 26087051 |
| chlamydia pneumoniae acute liver infection affects hepatic cholesterol and triglyceride metabolism in mice. | chlamydia pneumoniae has been linked to atherosclerosis, strictly associated with hyperlipidemia. the liver plays a central role in the regulation of lipid metabolism. since in animal models c. pneumoniae can be found at hepatic level, this study aims to elucidate whether c. pneumoniae infection accelerates atherosclerosis by affecting lipid metabolism. | 2015 | 26086356 |
| diagnosis and treatment of bacterial prostatitis. | prostate inflammation is a common syndrome, especially in men under 50. it usually presents with voiding symptoms and pain in the genitourinary area, and sometimes as sexual dysfunction. based on clinical and laboratory characteristics, prostatitis is classified as acute bacterial prostatitis, chronic bacterial prostatitis, chronic inflammatory and non-inflammatory prostatitis or chronic pelvic pain syndrome, and asymptomatic inflammatory prostatitis. bacterial prostatitis is most often caused b ... | 2015 | 26086164 |
| sample size considerations using mathematical models: an example with chlamydia trachomatis infection and its sequelae pelvic inflammatory disease. | the success of an intervention to prevent the complications of an infection is influenced by the natural history of the infection. assumptions about the temporal relationship between infection and the development of sequelae can affect the predicted effect size of an intervention and the sample size calculation. this study investigates how a mathematical model can be used to inform sample size calculations for a randomised controlled trial (rct) using the example of chlamydia trachomatis infecti ... | 2015 | 26084755 |
| chlamydia trachomatis inclusion disrupts host cell cytokinesis to enhance its growth in multinuclear cells. | chlamydia trachomatis, the leading cause of bacterial sexually transmitted infections, disrupts cytokinesis and causes significant multinucleation in host cells. here, we demonstrate that multinuclear cells that result from unsuccessful cell division contain significantly higher golgi content, an important source of lipids for chlamydiae. using immunofluorescence and fluorescent live cell imaging, we show that c. trachomatis in multinuclear cells indeed intercept golgi-derived lipid faster than ... | 2016 | 26084267 |
| male circumcision and sti acquisition in britain: evidence from a national probability sample survey. | it is well-established that male circumcision reduces acquisition of hiv, herpes simplex virus 2, chancroid, and syphilis. however, the effect on the acquisition of non-ulcerative sexually transmitted infections (stis) remains unclear. we examined the relationship between circumcision and biological measures of three stis: human papillomavirus (hpv), chlamydia trachomatis and mycoplasma genitalium. | 2015 | 26083250 |
| which sexually active young female students are most at risk of pelvic inflammatory disease? a prospective study. | to identify risk factors for pelvic inflammatory disease (pid) in female students. | 2015 | 26082320 |
| transcriptional regulation of the chlamydia heat shock stress response in an intracellular infection. | bacteria encode heat shock proteins that aid in survival during stressful growth conditions. in addition, the major heat shock proteins of the intracellular bacterium chlamydia trachomatis have been associated with immune pathology and disease. we developed a chip-qpcr method to study the regulation of chlamydial heat shock gene regulation during an intracellular infection. this approach allowed us to show that chlamydial heat shock genes are regulated by the transcription factor hrca within an ... | 2015 | 26075961 |
| overdiagnosis of urinary tract infection and underdiagnosis of sexually transmitted infection in adult women presenting to an emergency department. | urinary tract infections (utis) and sexually transmitted infections (stis) are commonly diagnosed in emergency departments (eds). distinguishing between these syndromes can be challenging because of overlapping symptomatology and because both are associated with abnormalities on urinalysis (ua). we conducted a 2-month observational cohort study to determine the accuracy of clinical diagnoses of uti and sti in adult women presenting with genitourinary (gu) symptoms or diagnosed with gu infections ... | 2015 | 26063863 |
| characteristics of women enrolled into a randomized clinical trial of dapivirine vaginal ring for hiv-1 prevention. | women in sub-saharan africa are a priority population for evaluation of new biomedical hiv-1 prevention strategies. antiretroviral pre-exposure prophylaxis is a promising prevention approach; however, clinical trials among young women using daily or coitally-dependent products have found low adherence. antiretroviral-containing vaginal microbicide rings, which release medication over a month or longer, may reduce these adherence challenges. | 2015 | 26061040 |
| in contrast to chlamydia trachomatis, waddlia chondrophila grows in human cells without inhibiting apoptosis, fragmenting the golgi apparatus, or diverting post-golgi sphingomyelin transport. | the chlamydiales are an order of obligate intracellular bacteria sharing a developmental cycle inside a cytosolic vacuole, with very diverse natural hosts, from amoebae to mammals. the clinically most important species is chlamydia trachomatis. many uncertainties remain as to how chlamydia organizes its intracellular development and replication. the discovery of new chlamydiales species from other families permits the comparative analysis of cell-biological events and may indicate events that ar ... | 2015 | 26056386 |
| conquering chlamydia. | chlamydia trachomatis, a gram-negative bacterium that often causes no symptoms, is creating a hidden epidemic. the asymptomatic nature of chlamydia promotes its spread; chlamydia is the most commonly reported notifiable disease in the united states. nurse practitioners, as community members, create the optimal foundation for a healthy community. an interventional community approach to capture and treat asymptomatic chlamydia through the use of open and honest communication in a university health ... | 2014 | 26050420 |
| exposure to an indoor cooking fire and risk of trachoma in children of kongwa, tanzania. | elimination of blinding trachoma by 2020 can only be achieved if affected areas have effective control programs in place before the target date. identifying risk factors for active disease that are amenable to intervention is important to successfully design such programs. previous studies have linked sleeping by a cooking fire to trachoma in children, but not fully explored the mechanism and risks. we propose to determine the risk for active trachoma in children with exposure to cooking fires b ... | 2015 | 26046359 |
| the proteome of the isolated chlamydia trachomatis containing vacuole reveals a complex trafficking platform enriched for retromer components. | chlamydia trachomatis is an important human pathogen that replicates inside the infected host cell in a unique vacuole, the inclusion. the formation of this intracellular bacterial niche is essential for productive chlamydia infections. despite its importance for chlamydia biology, a holistic view on the protein composition of the inclusion, including its membrane, is currently missing. here we describe the host cell-derived proteome of isolated c. trachomatis inclusions by quantitative proteomi ... | 2015 | 26042774 |
| the prevalence of endocervical chlamydia trachomatis infection among young females in kashan, iran. | chlamydia trachomatis is one of the major bacterial agents of the sexually transmitted diseases worldwide, especially among young females. there is no data regarding the prevalence of genital chlamydia infection among young females in kashan, iran. | 2015 | 26034530 |
| screening for chlamydia trachomatis in egyptian women with unexplained infertility, comparing real-time pcr techniques to standard serology tests: case control study. | to study the prevalence of chlamydia infection in women with primary and secondary unexplained infertility using elisa technique for antibody detection and real time, fully automated pcr for antigen detection and to explore its association with circulating antisperm antibodies (asa). | 2015 | 26031715 |
| rho gtpases as pathogen targets: focus on curable sexually transmitted infections. | pathogens have evolved highly specialized mechanisms to infect hosts. several microorganisms modulate the eukaryotic cell surface to facilitate their engulfment. once internalized, they hijack the molecular machinery of the infected cell for their own benefit. at different stages of phagocytosis, particularly during invasion, certain pathogens manipulate pathways governed by small gtpases. in this review, we focus on the role of rho proteins on curable, sexually transmitted infections caused by ... | 2015 | 26023809 |
| pcr detection and identification of bacterial contaminants in ocular samples from post-operative endophthalmitis. | bacterial endophthalmitis is a sight-threatening complication of ocular surgery which requires urgent medical consideration including comprehensive diagnosis. polymerase chain reaction (pcr) as a sensitive molecular method has been extensively used for detection of microbial species in clinical specimens. | 2015 | 26023576 |
| maternal exposure to sexually transmitted infections and schizophrenia among offspring. | animal models and epidemiologic studies suggest that prenatal maternal infection, and sexually transmitted infection (sti) in particular, is associated with an increased risk of schizophrenia in the offspring. however, findings from prior research studies on common infections, including herpes simplex virus type 2 (hsv-2) and chlamydia trachomatis (c. trachomatis) have been inconsistent. to investigate these associations, we conducted a case-control study nested in the population-based finnish p ... | 2015 | 26022653 |
| developing and testing accelerated partner therapy for partner notification for people with genital chlamydia trachomatis diagnosed in primary care: a pilot randomised controlled trial. | accelerated partner therapy (apt) is a promising partner notification (pn) intervention in specialist sexual health clinic attenders. to address its applicability in primary care, we undertook a pilot randomised controlled trial (rct) of two apt models in community settings. | 2015 | 26019232 |
| current status of the screening of chlamydia trachomatis infection among japanese pregnant women. | 2015 | 26015828 | |
| detection of chlamydia trachomatis, ureaplasma urealyticum and mycoplasma hominis in infertile bulgarian men with multiplex real-time polymerase chain reaction. | the effect of chlamydia trachomatis, ureaplasma urealyticum and mycoplasma hominis over the sperm quality is still unclear. the aim of this study was to determine their prevalence in infertile bulgarian men. a total of 281 men were examined by applying mrt-pcr. the registered prevalence was as follows: c. trachomatis - 13.9%, u. urealyticum - 19.2%, m. hominis - 9.9%. co-infection was established in eight swabs. this first in bulgaria to study for detection of chlamydia and mycoplasmas in infert ... | 2015 | 26010780 |
| evaluating hiv prevention programs: herpes simplex virus type 2 antibodies as biomarker for sexual risk behavior in young adults in resource-poor countries. | measuring effectiveness of hiv prevention interventions is challenged by bias when using self-reported knowledge, attitude or behavior change. hiv incidence is an objective marker to measure effectiveness of hiv prevention interventions, however, because new infection rates are relatively low, prevention studies require large sample sizes. herpes simplex virus type 2 (hsv-2) is similarly transmitted and more prevalent and could thus serve as a proxy marker for sexual risk behavior and therefore ... | 2015 | 26010772 |
| prevalence of sexually transmitted pathogens associated with hpv infection in cervical samples in a mexican population. | cervical cancer development has been mainly associated with persistent human papillomavirus (hpv) infections. however, hpv infection is unlikely to be sufficient to cause cervical cancer, and the contribution of other sexually transmitted infections (stis) could be the determining factor for cervical lesion-progression. the aim of this study was to estimate the prevalence of stis associated with hpv-positivity in 201 cervical samples from patients who underwent annual routine gynecological exams ... | 2015 | 26010580 |
| 2015 uk national guideline on the management of non-gonococcal urethritis. | we present the updated british association for sexual health and hiv guideline for the management of non-gonococcal urethritis in men. this document includes a review of the current literature on its aetiology, diagnosis and management. in particular it highlights the emerging evidence that azithromycin 1 g may result in the development of antimicrobial resistance in mycoplasma genitalium and that neither azithromycin 1 g nor doxycycline 100 mg twice daily for seven days achieves a cure rate of ... | 2016 | 26002319 |
| which sexually active female students get themselves tested for chlamydia trachomatis? a cohort study. | using data from the prevention of pelvic infection (popi) chlamydia screening trial, we compared the characteristics of female students who did or did not get tested for chlamydia outside the trial during 12 months' follow-up. of the 2529 women in the trial, we excluded 68 chlamydia positives in the intervention group who were referred for treatment at baseline. of the remaining 2461 women, 1980 (80%) answered the question about testing during follow-up on their 12 months' questionnaire and were ... | 2016 | 25999170 |
| chlamydia trachomatis relies on autonomous phospholipid synthesis for membrane biogenesis. | the obligate intracellular parasite chlamydia trachomatis has a reduced genome and is thought to rely on its mammalian host cell for nutrients. although several lines of evidence suggest c. trachomatis utilizes host phospholipids, the bacterium encodes all the genes necessary for fatty acid and phospholipid synthesis found in free living gram-negative bacteria. bacterially derived phospholipids significantly increased in infected hela cell cultures. these new phospholipids had a distinct molecul ... | 2015 | 25995447 |
| aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections. | the antibiotic spectinomycin is a potent inhibitor of bacterial protein synthesis with a unique mechanism of action and an excellent safety index, but it lacks antibacterial activity against most clinically important pathogens. a series of n-benzyl-substituted 3'-(r)-3'-aminomethyl-3'-hydroxy spectinomycins was developed on the basis of a computational analysis of the aminomethyl spectinomycin binding site and structure-guided synthesis. these compounds had ribosomal inhibition values comparable ... | 2015 | 25995221 |
| chlamydia trachomatis serotype a infections in the amazon region of brazil: prevalence, entry and dissemination. | chlamydia infection is associated with debilitating human diseases including trachoma, pneumonia, coronary heart disease and urogenital diseases. serotypes of c. trachomatis show a fair correlation with the group of diseases they cause, and their distribution follows a well-described geographic pattern. serotype a, a trachoma-associated strain, is known for its limited dissemination in the middle east and northern africa. however, knowledge on the spread of bacteria from the genus chlamydia as w ... | 2015 | 25992931 |
| inhibitory activities of the marine streptomycete-derived compound sf2446a2 against chlamydia trachomatis and schistosoma mansoni. | infectious diseases caused by chlamydia or schistosomes are a major health problem worldwide, and particularly so in developing countries. the lack of appropriate vaccines renders the search for potent natural products against these disease-causing agents an urgent endeavor. sponge-associated actinomycetes represent a rich reservoir for natural products. among them, members of the genus streptomyces are capable of synthesizing an impressive array of diverse natural products with a wide variety o ... | 2015 | 25990954 |
| diversity of cervicovaginal cytokine response to incident chlamydia trachomatis infection among a prospective cohort of young women. | animal, in vitro, and ex vivo studies have identified several cytokines involved in host immunity to genital chlamydia trachomatis (ct) infection. however, in vivo cytokine responses are not well described. our objectives were to document cervicovaginal cytokine levels and intrawoman cytokine changes during incident ct in a prospective cohort. | 2015 | 25989718 |
| cost-effectiveness of chlamydia vaccination programs for young women. | we explored potential cost-effectiveness of a chlamydia vaccine for young women in the united states by using a compartmental heterosexual transmission model. we tracked health outcomes (acute infections and sequelae measured in quality-adjusted life-years [qalys]) and determined incremental cost-effectiveness ratios (icers) over a 50-year analytic horizon. we assessed vaccination of 14-year-old girls and catch-up vaccination for 15-24-year-old women in the context of an existing chlamydia scree ... | 2015 | 25989525 |
| pathogenesis of progressive scarring trachoma in ethiopia and tanzania and its implications for disease control: two cohort studies. | trachoma causes blindness through a conjunctival scarring process initiated by ocular chlamydia trachomatis infection; however, the rates, drivers and pathophysiological determinants are poorly understood. we investigated progressive scarring and its relationship to conjunctival infection, inflammation and transcript levels of cytokines and fibrogenic factors. | 2015 | 25970613 |
| the role of chlamydia trachomatis in high-risk human papillomavirus persistence among female sex workers in nairobi, kenya. | little is known about risk factors for persistent high-risk human papillomavirus (hrhpv) infection in low-income settings, and prior research has not quantified the relative duration of hrhpv infections stratified by risk factors. we compared the duration of hrhpv infection among female sex workers (fsws) by exposure to sexually transmitted infections (stis), using a highly sensitive biomarker assay. | 2015 | 25970306 |
| interpretation of laboratory detection trends for chlamydia trachomatis and neisseria gonorrhoeae: manitoba, canada, 2000-2012. | increases in case numbers for chlamydia trachomatis (ct) and neisseria gonorrhoeae (ng) have been noted on a global level. this study analysed 13 years of testing data to better understand case detection trends over time. | 2016 | 25969541 |
| high prevalence of co-infections by invasive and non-invasive chlamydia trachomatis genotypes during the lymphogranuloma venereum outbreak in spain. | the evolution of chlamydia trachomatis is mainly driven by recombination events. this fact can be fuelled by the coincidence in several european regions of the high prevalence of non-invasive urogenital genotypes and lymphogranuloma venereum (lgv) outbreaks. this scenario could modify the local epidemiology and favor the selection of new c. trachomatis variants. quantifying the prevalence of co-infection could help to predict the potential risk in the selection of new variants with unpredictable ... | 2015 | 25965545 |
| engineering of a novel adjuvant based on lipid-polymer hybrid nanoparticles: a quality-by-design approach. | the purpose of this study was to design a novel and versatile adjuvant intended for mucosal vaccination based on biodegradable poly(dl-lactic-co-glycolic acid) (plga) nanoparticles (nps) modified with the cationic surfactant dimethyldioctadecylammonium (dda) bromide and the immunopotentiator trehalose-6,6'-dibehenate (tdb) (caf01) to tailor humoral and cellular immunity characterized by antibodies and th1/th17 responses. such responses are important for the protection against diseases caused by ... | 2015 | 25957906 |
| prevalence and correlates of trichomonas vaginalis infection among female sex workers in a city in yunnan province, china. | sexual transmission is the fastest growing route of hiv transmission in china, and trichomonas vaginalis(tv) can facilitate hiv transmission and acquisition. our goal was to determine the prevalence and correlates of tv infection among female sex workers (fsws). this cross-sectional study was conducted in a city of yunnan province in southern china, with confidential face-to-face interviews and laboratory tests for tv (wet mount) and other sexually transmitted infections. a total of 734 fsws par ... | 2016 | 25957327 |
| rectal chlamydia infection in women at high risk of chlamydia attending canberra sexual health centre. | chlamydia is the most commonly notified sexually transmitted infection in australia. australian guidelines recommend urogenital screening in asymptomatic men and women, and rectal screening in men who have sex with men or women reporting anal sex/symptoms. international studies describe a rectal chlamydia prevalence in women of 5% to 21%. we found that in women at high risk of chlamydia, 57% (32/56) tested positive for rectal chlamydia. of these, 97% (31/32) had concurrent urogenital chlamydia. ... | 2016 | 25957326 |
| reactive arthritis in relation to internal derangements of the temporomandibular joint: a case control study. | the aim of this study was to find out if reactive arthritis was involved in the aetiology of chronic closed lock of the temporomandibular joint (tmj) by looking for bacterial antigens in the synovial membrane of the tmj, and by studying the antibody serology and carriage of human leucocyte antigen (hla) b27 in patients with chronic closed lock. patients with reciprocal clicking and healthy subjects acted as controls. we studied a total of 43 consecutive patients, 15 with chronic closed lock, 13 ... | 2015 | 25957137 |
| utility of microbiological profile of symptomatic vaginal discharge in rural women of reproductive age group. | symptomatic vaginal discharge is the most frequent symptom in women of reproductive age group. owing to social stigma majority of affected women hesitate to seek medical consultation. therefore the actual incidence of vaginal discharge is much more than what is reported. the aim of the study is to determine the microbiological profile of symptomatic vaginal discharge in rural area and its utility in the management of genital tract infection. | 2015 | 25954668 |
| using recombinant chlamydia trachomatis omp2 as antigen in diagnostic elisa test. | the obligate intracellular bacterium chlamydia trachomatis causes sexually transmissible diseases in human. timely and sensitive detection of this pathogen is very important. there are many cross-reactions in bacteriological and serological methods in detection of this type of pathogens. the aim of this study was to achieve a more specific antigen for serological tests. | 2014 | 25954485 |
| humoral immunity status if infertile men antisperm antibodies and various pathologies of reproductive organs. | the aim of the research was to study humoral immunity status of infertile men with high concentration of antisperm antibodies in blood plasma, sexually transmitted diseases (std) and various pathologies of reproductive system. analysis of 496 outpatient cards has been conducted. it was found, that patients with high levels of asa >150 mg/l, or average 100-150 mg/l, had statistically significant (p=0,001) high content of ig a and ig g relative to the control group. men with serum asa concentratio ... | 2015 | 25953941 |
| chlamydia trachomatis inclusion membrane protein ct850 interacts with the dynein light chain dynlt1 (tctex1). | chlamydia trachomatis actively subverts the minus-end directed microtubule motor, dynein, to traffic along microtubule tracks to the microtubule organizing center (mtoc) where it remains within a membrane bound replicative vacuole for the duration of its intracellular development. unlike most substrates of the dynein motor, disruption of the dynactin cargo-linking complex by over-expression of the p50 dynamitin subunit does not inhibit c. trachomatis transport. a requirement for chlamydial prote ... | 2015 | 25944661 |
| dibenzocyclooctadiene lignans from schisandra spp. selectively inhibit the growth of the intracellular bacteria chlamydia pneumoniae and chlamydia trachomatis. | lignans from schisandra chinensis berries show various pharmacological activities, of which their antioxidative and cytoprotective properties are among the most studied ones. here, the first report on antibacterial properties of six dibenzocyclooctadiene lignans found in schisandra spp. is presented. the activity was shown on two related intracellular gram-negative bacteria chlamydia pneumoniae and chlamydia trachomatis upon their infection in human epithelial cells. all six lignans inhibited c. ... | 2015 | 25944533 |
| differences in treatment of chlamydia trachomatis by ambulatory care setting. | chlamydia trachomatis (ct) is the most commonly reported sexually transmitted infection (sti) in the us and timely, correct treatment can reduce ct transmission and sequelae. emergency departments (ed) are an important location for diagnosing stis. this study compared recommended treatment of ct in eds to treatment in physician offices. five years of data (2006-2010) were analyzed from the national ambulatory medical care survey, and the national hospital ambulatory medical care surveys (nhamcs) ... | 2015 | 25940936 |
| chlamydia trachomatis genotypes in school adolescents, italy. | chlamydia trachomatis genogroups using ompa and multilocus sequence typing (mlst) were determined in consecutive isolates from school students aged 18 or older in the district of brescia, italy, 2012-2013. among 40 samples, 4 ompa genovars and 18 sts were identified. genovar e predominated (70 %) including five sts derived from st59 (29 % of all isolates). this study, combining ompa and mlst typing of c. trachomatis school teenagers, suggests limited mixing and sexual interchange in this populat ... | 2015 | 25940434 |
| mutational analysis of the chlamydia muridarum plasticity zone. | pathogenically diverse chlamydia spp. can have surprisingly similar genomes. chlamydia trachomatis isolates that cause trachoma, sexually transmitted genital tract infections (chlamydia), and invasive lymphogranuloma venereum (lgv) and the murine strain chlamydia muridarum share 99% of their gene content. a region of high genomic diversity between chlamydia spp. termed the plasticity zone (pz) may encode niche-specific virulence determinants that dictate pathogenic diversity. we hypothesized tha ... | 2015 | 25939505 |
| detection of mycoplasma genitalium from male primary urine specimens: an epidemiologic dichotomy with trichomonas vaginalis. | a total of 2750 male urines subjected to a transcription-mediated amplification (tma)-based mycoplasma genitalium assay yielded 188 positive results (6.84%). this rate was similar to chlamydia trachomatis (6.87%; p = 0.96) and greater than neisseria gonorrhoeae (4.0%) and trichomonas vaginalis (2.3%; p < 0.0002). mean age of m. genitalium-infected males (30.8) was similar to n. gonorrhoeae (p = 0.78) but less than t. vaginalis (mean, 41.6; p < 0.0001). a total of 266 sti clinic encounters had at ... | 2015 | 25934156 |
| comparison of substance use typologies as predictors of sexual risk outcomes in african american adolescent females. | african american female adolescents have a disproportionate risk of sexually transmitted infections (stis) and other adverse sexual health outcomes. both alcohol and marijuana use have been shown to predict sexual risk among young african american women. however, no studies have attempted to differentiate alcohol and marijuana typologies use as predictors of sexual risk outcomes exclusively among adolescents who use these substances. this study compared recent alcohol and/or marijuana use as pre ... | 2016 | 25929200 |
| risk of first cervical hpv infection and pre-cancerous lesions after onset of sexual activity: analysis of women in the control arm of the randomized, controlled patricia trial. | more information is needed about time between sexual initiation and human papillomavirus (hpv) infection and development of cervical precancer. | 2014 | 25927224 |
| female reproductive hormones and biomarkers of oxidative stress in genital chlamydia infection in tubal factor infertility. | genital chlamydia infection (gci) and the associated pathologies have been implicated in tubal infertility. though the actual pathologic mechanisms are still uncertain, oxidative stress and other factors have been implicated. the purpose of the study was to determine the possible contribution of female reproductive hormones and biomarkers of oxidative stress in genital chlamydial infection to tubal occlusion. | 2015 | 25927024 |
| global multilocus sequence type analysis of chlamydia trachomatis strains from 16 countries. | the uppsala university chlamydia trachomatis multilocus sequence type (mlst) database (http://mlstdb.bmc.uu.se) is based on five target regions (non-housekeeping genes) and the ompa gene. each target has various numbers of alleles-hctb, 89; ct058, 51; ct144, 30; ct172, 38; and pbpb, 35-derived from 13 studies. our aims were to perform an overall analysis of all c. trachomatis mlst sequence types (sts) in the database, examine sts with global spread, and evaluate the phylogenetic capability by us ... | 2015 | 25926497 |