Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| quest for the diagnosis. case 1: a neonatal zoonosis. neonatal pasteurella multocida septicaemia. | 2008 | 18254915 | |
| transmission of pathogenic respiratory bacteria to specific pathogen free pigs at slaughter. | the purpose of this study was to evaluate the transmission of pathogenic respiratory bacteria to thirteen 5-month-old specific pathogen free (spf) pigs, during the slaughtering process in a commercial slaughterhouse. before transportation, the spf pigs and the lorry were checked to confirm the absence of pathogenic respiratory bacteria. nine spf pigs (group 1) were in contact in a conventional slaughterhouse with finishing pigs, during 4h before slaughtering. four spf pigs (group 2) were slaught ... | 2008 | 18242013 |
| microorganisms associated with a pneumonic epizootic in rocky mountain bighorn sheep (ovis canadensis canadensis). | a comprehensive study of a pneumonic epizootic was initiated when the first signs of disease were noted in a metapopulation of bighorn sheep inhabiting hells canyon, bordering idaho, oregon, and washington. a total of 92 bighorn sheep were tested for etiologic agents during the following 6-mo study period. the study population included bighorn sheep believed to be the subpopulation in which disease was first noted, and these sheep were translocated to a holding facility in an effort to contain t ... | 2007 | 18229860 |
| immune evasion by pathogens of bovine respiratory disease complex. | bovine respiratory tract disease is a multi-factorial disease complex involving several viruses and bacteria. viruses that play prominent roles in causing the bovine respiratory disease complex include bovine herpesvirus-1, bovine respiratory syncytial virus, bovine viral diarrhea virus and parinfluenza-3 virus. bacteria that play prominent roles in this disease complex are mannheimia haemolytica and mycoplasma bovis. other bacteria that infect the bovine respiratory tract of cattle are histophi ... | 2007 | 18218162 |
| pasteurella multocida and bovine respiratory disease. | pasteurella multocida is a pathogenic gram-negative bacterium that has been classified into three subspecies, five capsular serogroups and 16 serotypes. p. multocida serogroup a isolates are bovine nasopharyngeal commensals, bovine pathogens and common isolates from bovine respiratory disease (brd), both enzootic calf pneumonia of young dairy calves and shipping fever of weaned, stressed beef cattle. p. multocida a:3 is the most common serotype isolated from brd, and these isolates have limited ... | 2007 | 18218157 |
| disruption of fak signaling: a side mechanism in cytotoxicity. | focal adhesion kinase (fak) is a non-receptor protein tyrosine kinase (ptk) which acts as an early modulator in the integrin signaling cascade. fak phosphorylation and its consequent activation regulate several basic biological cellular functions. on the contrary, dysregulation of fak signaling is implicated in the malignant transformation of cells, as well as in nonmalignant pathological conditions. with respect to cytotoxicity, accumulating data indicate that fak participates in the mechanism ... | 2008 | 18215454 |
| field trial of a pasteurella multocida extract vaccine in rabbits. | pasteurella multocida is a bacterial pathogen that can cause significant disease and subsequent effects on research activities involving rabbits. although several vaccines have been tested under laboratory conditions, field trials of vaccines for the control of p. multocida in rabbits are few. we used a potassium thiocyanate extract (pte) produced from p. multocida serotype d:3,12,15 to vaccinate pasteurella-free rabbits at their introduction into a colony having endemic infection with p. multoc ... | 2008 | 18210993 |
| pasteurella multocida in scavenging family chickens and ducks: carrier status, age susceptibility and transmission between species. | pasteurella multocida causes fowl cholera, a highly contagious and severe disease in chickens and water fowls. the disease is not well described in less intensive production systems, including scavenging family poultry production in developing countries. p. multocida was isolated from 25.9% of healthy-looking ducks and 6.2% of chickens from free-range family poultry farms and at slaughter slabs at market. on experimental infection with 1.2 to 2.0 x 10(8) organisms of the p. multocida type strain ... | 2008 | 18202950 |
| application of intact cell-based nfat-beta-lactamase reporter assay for pasteurella multocida toxin-mediated activation of calcium signaling pathway. | pasteurella multocida toxin (pmt) stimulates and subsequently uncouples phospholipase c beta1 (plcbeta1) signal transduction through its selective action on the alpha subunit of the gq-protein. here, we describe the application of an nfat-beta-lactamase reporter assay as a functional readout for pmt-induced activation of the gq-protein-coupled plcbeta1-ip(3)-ca(2+) signaling pathway. use of the nfat-beta-lactamase reporter assay with a cell-permeable fluorogenic substrate provides high sensitivi ... | 2008 | 18190943 |
| susceptibility testing of tulathromycin: interpretative breakpoints and susceptibility of field isolates. | in vitro susceptibility tests were conducted on bovine and porcine respiratory pathogens isolated from european countries during 2004-2006 for susceptibility to tulathromycin using the recommended methodologies for broth microdilution. the results were compared with data from a similar survey conducted prior to launch in 1998-2001 to monitor for any shift in susceptibility. the importance of maintaining the ph of the culture media within the range 7.2-7.4 was re-affirmed as a key factor in obtai ... | 2008 | 18187275 |
| cat got your tongue? | 2008 | 18171232 | |
| novel adhesin from pasteurella multocida that binds to the integrin-binding fibronectin fniii9-10 repeats. | phage display screening with fragmented genomic dna from the animal pathogen pasteurella multocida has identified a gene encoding a putative fibronectin binding protein (19). homologues of this gene (pm1665) are found in all other sequenced members of the pasteurellaceae. gene pm1665 has been cloned, and the protein has been expressed. recombinant pm1665 protein binds to both soluble and immobilized fibronectin and is unique in that it interacts with the integrin-binding fibronectin type iii (fn ... | 2008 | 18160478 |
| fowl cholera; pasteurella multocida. | 1949 | 18124873 | |
| [pasteurella multocida pneumonia with molecular evidence of zoonotic transmission]. | we report the case of a patient with pneumonia caused by pasteurella multocida (p. multocida). an 83-year-old woman admitted for bronchiectasis, productive cough, and a high fever was found in chest radiography on admission to have a new infiltrative shadow in the left lower lung field. chest computed tomography indicated bilateral bronchiectasis and an infiltrative lingular shadow. p. multocida was isolated from sputum samples. biapenem and minocycline therapy ameliorated symptoms. pulsed-field ... | 2007 | 18095473 |
| diagnosis | pasteurellosis. | 2008 | 18094697 | |
| diagnostic and typing options for investigating diseases associated with pasteurella multocida. | pasteurella multocida is responsible for major animal diseases of economic significance in both developed and developing countries whereas human infections related to this bacterium are infrequent. significantly, development of a carrier status or latent infections plays a critical role in the epidemiology of these diseases. aiming at increased knowledge of these infections, we examine potential diagnostic and selected typing systems for investigating diseases caused by p. multocida. detection o ... | 2008 | 18061377 |
| pasteurella multocida infections. | 2007 | 18055649 | |
| pasteurella multocida infections: i. pasteurella multocida infection due to animal bite. | 1970 | 18018289 | |
| n-acetylcysteine stimulates osteoblastic differentiation of mouse calvarial cells. | estrogen deficiency causes osteoporosis via increased generation of reactive oxygen species (ros), and thus, antioxidants may prove to be the effective therapeutic candidates. we examined the effects of the antioxidant n-acetylcysteine (nac) on osteoblastic differentiation in mouse calvarial cells. nac (10-30 mm) enhanced alkaline phosphatase activity, mrna expression of osteoblast differentiation-associated genes and mineralized nodule formation. it also increased expression of bone morphogenet ... | 2008 | 17979115 |
| shuffling of pig interleukin-2 gene and its enhancing of immunity in mice to pasteurella multocida vaccine. | in order to explore the safe and effective adjuvant for promotion of immunity of animals against infection, the experiment was carried out to shuffle tibet pig il-2 cdna with other il-2 cdna from human, yak and mouse, and the effect of shuffled il-2 (il-2s) gene in vivo was investigated on immunity of mice to pasteurella multocida. the il-2s protein was found to remarkably promote the proliferation of pig lymphoblasts than the native pig il-2 protein. then the il-2s gene was cloned into vr1020 e ... | 2007 | 17959278 |
| pasteurella multocida bacteremia in asymptomatic plateletpheresis donors: a tale of two cats. | bacterial contamination of platelet (plt) concentrates occurs in 1 in 1000 to 1 in 3000 components and has been a leading cause of transfusion-associated morbidity and mortality. two cases of pasteurella multocida bacteremia in asymptomatic plateletpheresis donors are reported. clinical outcomes were profoundly different, emphasizing the importance of robust methods to detect bacterial contamination. | 2007 | 17958526 |
| accuracy of susceptibility testing of pasteurella multocida and mannheimia haemolytica. | the accuracy of antimicrobial susceptibility determinations relies on the bacterial species identification and the test methodology that is being used. in the present study, both aspects were investigated for 141 pasteurella multocida and 34 mannheimia haemolytica sensu lato isolates recovered from the upper respiratory tract of healthy calves. this was performed on the one hand by comparing of classical phenotyping with tdna-pcr genotyping and on the other hand by pairwise comparison of disk di ... | 2007 | 17949308 |
| reversible myocardial depression associated with sepsis in a dog. | 2007 | 17939574 | |
| quantitative resistance level (mic) of bacterial pathogens (escherichia coli, pasteurella multocida, pseudomonas aeruginosa, salmonella sp., staphylococcus aureus) isolated from chickens and turkeys: national resistance monitoring by the bvl 2004/2005. | in the study 2004/2005, the current quantitative resistance level of escherichia coli, pasteurella multocida, pseudomonas aeruginosa, salmonella sp. and staphylococcus aureus from chickens and turkeys was determined for the first time within the framework of the national resistance monitoring of the federal office of consumer protection and food safety (bvl). the objective was to implement a valid database on the basis of which the development and spread of resistance can be evaluated and monito ... | 2007 | 17939460 |
| quantitative resistance level (mic) of pasteurella multocida isolated from pigs between 2004 and 2006: national resistance monitoring by the bvl. | the national resistance monitoring of the federal office of consumer protection and food safety (bvl) is to determine the prevalence of resistance of bacterial pathogens from animals using a valid database. from 2004 to 2006, a total of 1,472 pasteurella multocida strains isolated from pigs with acute respiratory tract diseases was submitted to the bvl and examined. of these, 1,11 (75.5 %) were included in the study and tested using 24 different antimicrobial substances. the results showed that ... | 2007 | 17939459 |
| antimicrobial susceptibility of pasteurella multocida and bordetella bronchiseptica from dogs and cats as determined in the bft-germvet monitoring program 2004-2006. | a total of 92 canine/feline pasteurella multocida strains form respiratory tract infections or infections of skin/ear/mouth as well as 42 canine/feline bordetella bronchiseptica strains from respiratory tract infections were investigated for their susceptibility to antimicrobial agents. while the p. multocida strains were susceptible to all antimicrobial agents tested - except sulfonamides -, a considerable number of the b. bronchiseptica strains was resistant or exhibited high mic values agains ... | 2007 | 17939457 |
| susceptibility of bacterial pathogens against lincomycin/spectinomycin (1/2), penicillin g/neomycin (1/1), and penicillin g/dihydrostreptomycin (1/1) as determined in the bft-germvet monitoring program 2004-2006. | a total of 368 bacterial pathogens, including 72 coagulase-positive and coagulase-variable staphylococci, 97 beta-haemolytic streptococci, 51 escherichia coli, 75 pasteurella multocida, 25 mannheimia haemolytica, 25 pseudomonas aeruginosa, and 23 arcanobacterium pyogenes, were investigated for their susceptibility to the three combinations of antimicrobial agents lincomycin/spectinomycin (1/2), penicillin g/neomycin (1/1), and penicillin g/dihydrostreptomycin (1/1) in comparison to their suscept ... | 2007 | 17939451 |
| dna fingerprinting analysis of breakthrough outbreaks in vaccine-protected poultry stocks. | we report recurrent outbreaks of yersinia pseudotuberculosis conjunctivitis in ducks and of fowl cholera in geese, occurring in stocks previously vaccinated with inactivated autogenous vaccines. enterobacterial repetitive intergenic consensus sequence-based pcr and pulsed-field gel electrophoresis indicated reinfection with a new y. pseudotuberculosis strain and vaccine evasion by the same pasteurella multocida strain. | 2007 | 17928428 |
| inhibition of trpc5 channels by intracellular atp. | trpc5 channels are ca(2+)-permeable nonselective cation channels activated by g-protein-coupled receptors, although the mechanisms responsible for channel activation and regulation are poorly understood. carbachol-activated trpc5 currents were recorded by the whole-cell patch clamp technique from human embryonic kidney 293 cells transiently transfected with trpc5 and the m1 muscarinic receptor. some published studies of trpc5 currents have included atp and/or gtp in the patch pipette, whereas ot ... | 2008 | 17925457 |
| a multidomain outer membrane protein from pasteurella multocida: modelling and simulation studies of pmompa. | pmompa is a two-domain outer membrane protein from pasteurella multocida. the n-terminal domain of pmompa is a homologue of the transmembrane beta-barrel domain of ompa from escherichia coli, whilst the c-terminal domain of pmompa is a homologue of the extra-membrane neisseria meningitidis rmpm c-terminal domain. this enables a model of a complete two domain pmompa to be constructed and its conformational dynamics explored via md simulations of the protein embedded within two different phospholi ... | 2007 | 17888868 |
| safety and protective efficacy of intramuscular vaccination with a live aroa derivative of pasteurella multocida b:2 against experimental hemorrhagic septicemia in calves. | three groups of five calves, namely, v1, v2, and v3, were immunized intramuscularly at 4 and 8 weeks of age with ca. 10(9), 10(8), and 10(7) cfu, respectively, of a derivative of pasteurella multocida b:2 wild-type strain 85020 containing a deletion in the aroa gene (strain jrmt12). the first and second vaccinations resulted in significantly (p < 0.01) higher rectal temperature responses in groups v1 and v2 than in group v3. serum immunoglobulin m (igm) and igg titers did not increase in any gro ... | 2007 | 17875632 |
| evaluation of goose serum amyloid a acute phase response by enzyme-linked immunosorbent assay. | serum amyloid a (saa) is of interest as the circulating precursor of amyloid a protein, the fibrillar component of aa (secondary) amyloid deposits, and also as an extremely sensitive and rapid major acute phase protein. serum concentrations of acute phase proteins (apps) provide valuable information about the diagnosis and prognosis of various diseases, and thus the relevance of apps for monitoring the health status of domestic animals is widely accepted. more importantly, the measurement of saa ... | 2007 | 17867462 |
| immunological roles of pasteurella multocida toxin (pmt) using a pmt mutant strain. | the immunological role of the pasteurella multocida toxin (pmt) in mice was examined using a pmt mutant strain. after a nasal inoculation, the mutant strain failed to induce interstitial pneumonia. moreover, pmt had no significant effect on the populations of cd4+, cd8+, cd3+, and cd19+ immunocytes in blood or on the populations of cd4+ and cd8+ splenocytes (p<0.01). however, there was a significant increase in the total number of cells in the bal samples obtained from the wild-type p. multocida ... | 2007 | 17846592 |
| please, do not forget pasteurella multocida. | 2007 | 17806067 | |
| [pasteurella multocida meningitis: zoonosis by pets]. | 2007 | 17802726 | |
| pasteurella multocida sepsis and meningitis in 2-month-old twin infants after household exposure to a slaughtered sheep. | this article outlines 2 cases of pasteurella multocida sepsis and meningitis in 2-month-old twins after their father was exposed to a sheep during a sacrifice celebration at home. these cases emphasize the necessity of respecting basic hygiene rules and the danger involved in animal sacrifice without suitable professional structure. | 2007 | 17712748 |
| contamination of post-endoscopic sinus surgery sinus cavities with pasteurella multocida. | 2007 | 17711761 | |
| recombinant synthesis of hyaluronan by agrobacterium sp. | hyaluronan (ha) is a sugar polymer of a repeating disaccharide, beta1-3 d-n-acetylglucosamine (glcnac) beta1-4 d-glucuronic acid (glca). it finds applications in numerous biomedical procedures such as ophthalmic surgery and osteoarthritis treatment. until recently, the only commercial sources were extraction of rooster combs and from fermentation of pathogenic streptococcus. in this work, we demonstrate that metabolic engineering strategies enable the recombinant synthesis of hyaluronan in a saf ... | 2007 | 17705506 |
| decoration of pasteurella multocida lipopolysaccharide with phosphocholine is important for virulence. | phosphocholine (pcho) is an important substituent of surface structures expressed by a number of bacterial pathogens. its role in virulence has been investigated in several species, in which it has been shown to play a role in bacterial adhesion to mucosal surfaces, in resistance to antimicrobial peptides, or in sensitivity to complement-mediated killing. the lipopolysaccharide (lps) structure of pasteurella multocida strain pm70, whose genome sequence is known, has recently been determined and ... | 2007 | 17704225 |
| nucleotide sequence and transfer properties of two novel types of actinobacillus pleuropneumoniae plasmids carrying the tetracycline resistance gene tet(h). | to analyse the sequence and transfer properties of two tetracycline resistance plasmids found in clinical isolates of actinobacillus pleuropneumoniae in order to assess their role in the spread of tetracycline resistance. | 2007 | 17704116 |
| peritonitis associated with pasteurella multocida in peritoneal dialysis patients--case report and review of the literature. | pasteurella multocida is a zoonotic pathogen found in the oral cavities of domestic dogs and cats and other wild and domestic animals. 14 cases ofperitoneal dialysis-associated pasteurella multocida peritonitis linked to animal contact have been reported in the literature to date. in each case, the source of infection was believed to be a domestic cat or cats. one case of spontaneous bacterial peritonitis has been reported in a cirrhotic patient and was not linked to animal contact. poor hygiene ... | 2007 | 17703837 |
| [knee prosthesis infection due to pasteurella multocida]. | 2007 | 17692220 | |
| pasteurella multocida septic shock following liver transplantation treated with drotrecogin alpha (activated). | severe sepsis and progression to septic shock in solid organ transplant recipients is associated with a high mortality. we describe a fulminant case of septic shock in a liver transplant recipient caused by pasteurella multocida, a gram-negative coccobacillus most commonly associated with domestic cats and dogs. p. multocida is a rare cause of bacteremia and has not been reported as a cause of septic shock following liver transplantation. in addition to standard therapy, the patient was managed ... | 2007 | 17692071 |
| [severe pasteurella multocida pneumonia by close contact with a pet in chronic respiratory failure]. | 2007 | 17682434 | |
| purification, crystallization and preliminary crystallographic characterization of the alpha 2,6-sialyltransferase from photobacterium sp. jt-ish-224. | sialyltransferases transfer sialic acid from cytidine-5-monophospho-n-acetylneuraminic acid (cmp-neuac) to the nonreducing termini of the oligosaccharyl structures of various glycoproteins and glycolipids. the newly cloned alpha2,6-sialyltransferase from photobacterium sp. jt-ish-224 (from the vibrionaceae family) is composed of two domains: an unknown n-terminal domain and a catalytic c-terminal domain which shares significant homology with the pasteurella multocida multifunctional sialyltransf ... | 2007 | 17671362 |
| action of pasteurella multocida toxin on galpha(q) is persistent and independent of interaction with g-protein-coupled receptors. | pasteurella multocida toxin (pmt) activates galpha(q) and facilitates stimulation of inositol phosphate accumulation induced by agonists via g(q)-coupled membrane receptors. here, we studied the effects of pmt on agonist-induced gtpgammas binding to g(q) in cell membranes and a role of g-protein-coupled receptors in the action of pmt. pre-treatment of swiss 3t3 cells with pmt increased bombesin or vasopressin-induced gtpgammas-binding in cell membranes by about 50 to 150%. increase in agonist-st ... | 2007 | 17669624 |
| pcr analysis of pasteurella multocida isolates from an outbreak of pasteurellosis in indian pigs. | an outbreak of pasteurellosis with high mortality was recorded in indigenous pigs in india. the presence of pasteurella multocida in samples collected from dead pigs was detected by smear examination and isolation, and later by p. multocida specific polymerase chain reaction (pm-pcr). p. multocida was detected in all the samples collected from dead pigs, with nine strains ultimately isolated. all the isolates were positive by pm-pcr. six isolates showed capa and three were of capd capsular types ... | 2008 | 17669491 |
| biochemical characterization of a neisseria meningitidis polysialyltransferase reveals novel functional motifs in bacterial sialyltransferases. | the extracellular polysaccharide capsule is an essential virulence factor of neisseria meningitidis, a leading cause of severe bacterial meningitis and sepsis. serogroup b strains, the primary disease causing isolates in europe and america, are encapsulated in alpha-2,8 polysialic acid (polysia). the capsular polymer is synthesized from activated sialic acid by action of a membrane-associated polysialyltransferase (nmb-polyst). here we present a comprehensive characterization of nmb-polyst. diff ... | 2007 | 17662040 |
| invasive pasteurella multocida sinusitis in a renal transplant patient. | pasteurella are commensal gram-negative bacteria isolated from the oral cavity of many domesticated animals. most human infections occur post animal bite or scratch injury resulting in local cutaneous infection; however, case reports suggest that transmission may occur via animal secretions. pasteurella species can be associated with serious systemic infections particularly in those with underlying disease and in the immunocompromised. we present a case of invasive pasteurella multocida sinusiti ... | 2008 | 17655653 |
| production of antibody in mammary gland of pregnant, non-lactating and lactating cows, evoked by polyvalent antigen with reference to dosage and frequency of immunization. | sixteen cows were used in a series of experiments to test dose, route and frequency responses in the production of milk and serum agglutinins to a spectrum of 9 proven bovine pathogens. the bacterial species were: pasteurella multocida (2 isolates), escherichia coli, staphylococcus aureus, staphylococcus albus, streptococcus sp., corynebacterium sp., salmonella enteriditis, and aerobacter aerogenes. primary immunizations were made either through the teat canal or intramuscularly. "booster" injec ... | 1964 | 17649521 |
| further observations on typing pasteurella multocida by the indirect hemagglutination test. | 1962 | 17649399 | |
| complement-fixation tests of swine serum ii. in the demonstration of pasteurella multocida antibodies in experimentally produced rhinitis. | 1955 | 17648843 | |
| a herd outbreak of mastitis caused by pasteurella multocida. | 1954 | 17648709 | |
| dissociation and virulence in strains of pasteurella multocida isolated from a variety of lesions. | 1953 | 17648678 | |
| rhinitis of swine. viii. experiments with pasteurella multocida. | 1953 | 17648676 | |
| rhinitis of swine. vii. production of lesions in pigs and rabbits with a pure culture of pasteurella multocida. | 1953 | 17648630 | |
| occurrence of antimicrobial resistance in bacteria from diagnostic samples from dogs. | to study the occurrence of antimicrobial resistance among common bacterial pathogens from dogs and relate resistance patterns to data on consumption of antimicrobials. | 2007 | 17644533 |
| experimental study of pathogenicity of pasteurella multocida serogroup f in rabbits. | the role of pasteurella multocida serogroup f in inducing disease in rabbits was investigated in this study. three groups of 12 pasteurella-free rabbits each were intranasally (i.n.), subcutaneously (s.c.), and perorally (p.o.) challenged, respectively. six rabbits of each group were immunosuppressed using dexamethasone. eight rabbits (four of them immunosuppressed) inoculated i.n. showed symptoms of respiratory distress resulting in respiratory failure and died or were euthanized in the termina ... | 2008 | 17629636 |
| chemoenzymatic synthesis with distinct pasteurella heparosan synthases: monodisperse polymers and unnatural structures. | heparosan (-glcua-beta1,4-glcnac-alpha1,4-)(n) is a member of the glycosaminoglycan polysaccharide family found in the capsule of certain pathogenic bacteria as well as the precursor for the vertebrate polymers, heparin and heparan sulfate. the two heparosan synthases from the gram-negative bacteria pasteurella multocida, pmhs1 and pmhs2, were efficiently expressed and purified using maltose-binding protein fusion constructs. these relatively homologous synthases displayed distinct catalytic cha ... | 2007 | 17627940 |
| expression of the dermonecrotic toxin by bordetella bronchiseptica is not necessary for predisposing to infection with toxigenic pasteurella multocida. | this experiment was designed to determine whether a bordetella bronchiseptica mutant that does not produce dermonecrotic toxin (dnt) is still capable of predisposing pigs to infection with toxigenic pasteurella multocida. three groups of pigs were initially inoculated intranasally with a wild type b. bronchiseptica that produces dnt, an isogenic mutant of b. bronchiseptica that does not produce dnt, or pbs. all pigs were then challenged intranasally with a toxigenic strain of p. multocida 4 days ... | 2007 | 17624695 |
| clinical and in vitro efficacy of amoxicillin against bacteria associated with feline skin wounds and abscesses. | a clinical trial involving 122 cats with infected skin wounds or abscesses presented to 10 veterinary clinics was conducted to evaluate the efficacy of 2 oral amoxicillin drug products (a paste and a suspension). a 2nd objective of the study was to identify bacteria involved in such infections and verify their in vitro sensitivity to amoxicillin. samples of wound exudate were harvested at the time of presentation and submitted for aerobic and anaerobic culture. the sensitivity to amoxicillin of ... | 2007 | 17616057 |
| nucleoside analogues are activated by bacterial deoxyribonucleoside kinases in a species-specific manner. | to investigate the bactericidal activity of antiviral and anticancer nucleoside analogues against a variety of pathogenic bacteria and characterize the activating enzymes, deoxyribonucleoside kinases (dnks). | 2007 | 17615154 |
| evaluation of an indirect enzyme-linked immunosorbent assay (elisa) using recombinant toxin for detection of antibodies against pasteurella multocida toxin. | to facilitate the control of progressive atrophic rhinitis (par) of swine caused by toxigenic pasteurella multocida, an enzyme-linked immunosorbent assay (elisa) and a serum neutralization test (nt) have recently been developed to detect antibodies against the p. multocida dermonecrotic toxin (pmdnt). however, the nt is a cumbersome and time-consuming technique. to overcome these drawbacks, we developed an indirect elisa, using recombinant pmdnt expressed in escherichia coli, for the detection o ... | 2007 | 17611352 |
| ompa: gating and dynamics via molecular dynamics simulations. | outer membrane proteins (omps) of gram-negative bacteria have a variety of functions including passive transport, active transport, catalysis, pathogenesis and signal transduction. whilst the structures of approximately 25 omps are currently known, there is relatively little known about their dynamics in different environments. the outer membrane protein, ompa from escherichia coli has been studied extensively in different environments both experimentally and computationally, and thus provides a ... | 2008 | 17601489 |
| [monitoring of infectious diseases among wild boars]. | sixty-seven serum samples and 43 pathological material samples from wild boars, taken in 5 regions of russia and in the kharkov region of the ukraine in 2002 to 2005 were studied. wild boars in some regions of russia were shown to be carriers of aujeszky's disease virus, porcine parvovirus, porcine circovirus type 2, lymphotropic herpesvirus-1, porcine cytomegalovirus, mycoplasma hyopneumoniae and pasteurella multocida. the classical swine fever (csf) virus genome was detected by polymerase chai ... | 2007 | 17601049 |
| immune response in mice and swine to dna vaccines derived from the pasteurella multocida toxin gene. | dna vaccines were constructed with either a 5'-truncated or full-length, genetically detoxified toxin gene from pasteurella multocida and two different dna vaccine vectors, distinguished by the presence or absence of a secretion signal sequence. optimal pmt-specific antibody responses and spleen cell secretion of interferon-gamma following immunization of mice were achieved with pmm4, the construct containing a signal sequence and encoding the entire toxin. antibody responses were also induced i ... | 2007 | 17590484 |
| calcineurin-independent inhibition of 3t3-l1 adipogenesis by pasteurella multocida toxin: suppression of notch1, stabilization of beta-catenin and pre-adipocyte factor 1. | pasteurella multocida toxin (pmt) is a potent mitogen and a specific activator of gq-dependent signalling pathways. pmt impairs osteoblast differentiation and causes bone loss and fat reduction in vivo. we examined the effect of pmt on cell signalling pathways involved in 3t3-l1 adipocyte differentiation. we demonstrate that pmt treatment before or together with differentiation induction factors inhibits adipogenesis and prevents upregulation of important adipocyte markers - peroxisome-prolifera ... | 2007 | 17581254 |
| an investigation of the aetiological role of bovine herpesvirus 4 in bovine endometritis. | uteri from 31 infertile cattle were examined for the presence of bovine herpesvirus 4 (bohv-4) by nested polymerase chain reaction (pcr). samples were also tested for bacteria, including chlamydiae and mycoplasma bovis. bohv-4 was detected by pcr in 27/31 (87.1%) samples, but the presence and amount of viral dna was not correlated with histological and bacteriological findings. arcanobacterium pyogenes, histophilus somni and pasteurella multocida were isolated from five cows with endometritis. c ... | 2008 | 17572123 |
| outer membrane permeability for nonpolar antimicrobial agents underlies extreme susceptibility of pasteurella multocida to the hydrophobic biocide triclosan. | pasteurella multocida exhibits nonspecific susceptibility to nonpolar antimicrobial agents such as triclosan, despite possessing an ultrastructurally typical gram-negative cell envelope. capsulated and noncapsulated cell surface variants were examined to investigate the role outer membrane permeability plays in triclosan susceptibility. test strains were unable to initiate growth in the presence of bile salts and were susceptible to triclosan with minimal inhibitory concentrations (mics) ranging ... | 2007 | 17560745 |
| the cloning and sequencing of the udp-galactose 4-epimerase gene (gale) from avibacterium paragallinarum. | the putative uridine diphosphate (udp)-galactose 4-epimerase encoding gene, gale, was isolated from avibacterium paragallinarum with the use of degenerate primers, colony hybridization and inverse pcr. the data revealed an open reading frame of 1017 bp encoding a protein of 338 amino acids with a molecular weight of 37 kda and an isoelectric point of 5.5. high sequence homology was obtained with an 87, 91 and 89% sequence identity on protein level towards the gale genes from actinobacillus pleur ... | 2007 | 17541831 |
| molecular characterization of avian strains of pasteurella multocida serogroup-a:1 based on amplification of repetitive regions by pcr. | repetitive extragenic palindromic (rep)-pcr (polymerase chain reaction), enterobacterial repetitive intergenic consensus (eric)-pcr, and single primer pcr assays were employed to characterize 66 strains of pasteurella multocida serogroup a:1 isolated from avian species belonging to different regions of india. rep-pcr resulted in amplification of rep sequences from the genome which were in the range of approximately 200 to approximately 3000 bp and accounted for a total of 54 distinguishing profi ... | 2008 | 17537513 |
| pasteurella multocida expresses two lipopolysaccharide glycoforms simultaneously, but only a single form is required for virulence: identification of two acceptor-specific heptosyl i transferases. | lipopolysaccharide (lps) is a critical virulence determinant in pasteurella multocida and a major antigen responsible for host protective immunity. in other mucosal pathogens, variation in lps or lipooligosaccharide structure typically occurs in the outer core oligosaccharide regions due to phase variation. p. multocida elaborates a conserved oligosaccharide extension attached to two different, simultaneously expressed inner core structures, one containing a single phosphorylated 3-deoxy-d-manno ... | 2007 | 17517879 |
| crystal structures of pasteurella multocida sialyltransferase complexes with acceptor and donor analogues reveal substrate binding sites and catalytic mechanism. | sialyltransferases are key enzymes involved in the biosynthesis of biologically and pathologically important sialic acid-containing molecules in nature. binary x-ray crystal structures of a multifunctional pasteurella multocida sialyltransferase (delta24pmst1) with a donor analogue cmp-3f(a)neu5ac or cmp-3f(e)neu5ac were determined at 2.0 and 1.9 a resolutions, respectively. ternary x-ray structures of the protein in complex with cmp or a donor analogue cmp-3f(a)neu5ac and an acceptor lactose ha ... | 2007 | 17487984 |
| outer membrane protein h for protective immunity against pasteurella multocida. | pasteurella multocida, a gram-negative facultative anaerobic bacterium, is a causative animal pathogen in porcine atrophic rhinitis and avian fowl cholera. for the development of recombinant subunit vaccine against p. multocida, we cloned and analyzed the gene for outer membrane protein h (omph) from a native strain of pasteurella multocida in korea. the omph had significant similarity in both primary and secondary structure with those of other serotypes. the full-length, and three short fragmen ... | 2007 | 17483806 |
| comparative sequence analysis of 16s rrna gene of pasteurella multocida serogroup b isolates from different animal species. | the phylogenetic relationships of five isolates of pasteurella multocida serotype b:2 belonging to buffalo, cattle, pig, sheep and goat were investigated by comparative sequence analysis of 16s rrna gene. the 1468bp fragment of 16s rrna gene sequence comparison showed that the isolates of cattle (pm75), pig (pm49) and sheep (pm82) shared 99.9% homology with the buffalo isolate (vaccine strain p52) whereas, the goat isolate (pm86) shared 99.8% homology with the vaccine strain. the 16s rrna gene s ... | 2007 | 17459437 |
| successful treatment of cervical spinal epidural empyema secondary to grass awn migration in a cat. | spinal epidural empyema (see) represents a severe pyogenic infection of the epidural space. clinical signs of the disease are non-specific--increased body temperature, intense neck pain, neurological signs of a transverse myelopathy--and can lead to severe and permanent neurological deficits. this report describes the diagnosis and successful surgical treatment of cervical see secondary to grass awn migration in a cat. although it is uncommon, this disease should be suspected in cats with progre ... | 2007 | 17449314 |
| protective immunity conferred by recombinant pasteurella multocida lipoprotein e (plpe). | the genes encoding pasteurella multocida lipoprotein e (plpe) and lipoprotein b (plpb) were cloned from p. multocida strain x-73 (serotype a:1) and expressed in escherichia coli. the protective immunity conferred by recombinant plpe (r-plpe) and plpb (r-plpb) on mice and chickens was evaluated. the results showed that mice immunized with 10microg of purified r-plpe were protected (80-100% survival rate) against challenge infection with 10 or 20 ld(50) of p. multocida strains x-73 (serotype a:1), ... | 2007 | 17449151 |
| pasteurella meningo-encephalitis--a risk of household pets. | 2007 | 17442396 | |
| ultrastructural characteristics of the external surfaces of pasteurella pneumotropica from mice and pasteurella multocida from rabbits. | the surface structures of the cells of pasteurella pneumotropica from mice and pasteurella multocida from rabbits were examined by transmission electron microscopy after ruthenium red staining and polycationic ferritin labelling. p. pneumotropica strains atcc 35149 and k 79114 had slight extracellular fibrous materials associated with cell walls with ruthenium red staining. ferritin labelling method revealed thick strands or sparsely ferritin-labelled materials on the cell surface of the strains ... | 2007 | 17430628 |
| pasteurella multocida empyema. | 1996 | 17429265 | |
| efficacy of sulbactam, a b-lactamase inhibitor, combined with ampicillin in the therapy of ampicillin-resistant pneumonic pasteurellosis in veal calves. | two field efficacy studies, involving a total of 92 naturally infected, pneumonic veal calves, were conducted to compare the efficacy of the beta-lactamase inhibitor sulbactam plus ampicillin to ampicillin alone in the treatment of bacterial pneumonia. cultures from nasal swabs and lung tissue during the 10 or 11 day studies were predominantly ampicillin-resistant pasteurella multocida. ampicillin (6.6 mg/kg) or sulbactam-ampicillin (3.3 mg/kg sulbactam + 6.6 mg/kg ampicillin) was injected intra ... | 1987 | 17422867 |
| serotypes and antimicrobial susceptibility of pasteurella multocida isolated from cattle and pigs in ontario. | 1984 | 17422356 | |
| an epizootic of swine influenza in ontario. | a swine influenza virus (h(1)n(1)) was isolated for the first time in ontario from pigs one week to one and one-half years old during an epizootic which occurred between january and may 1981. each herd outbreak was characterized by the sudden onset of marked respiratory distress, usually affecting the entire herd, accompanied by paroxysmal coughing, anorexia, prostration and temperatures as high as 41.5 degrees c and lasting for five to seven days. morbidity was nearly 100%; mortality was less t ... | 1983 | 17422266 |
| immunological differentiation of type b and e strains of pasteurella multocida. | 1963 | 17421584 | |
| one-pot three-enzyme chemoenzymatic approach to the synthesis of sialosides containing natural and non-natural functionalities. | chemoenzymatic synthesis, which combines the flexibility of chemical synthesis and the high selectivity of enzymatic synthesis, is a powerful approach to obtain complex carbohydrates. it is a preferred method for synthesizing sialic acid-containing structures, including those with diverse naturally occurring and non-natural sialic acid forms, different sialyl linkages and different glycans that link to the sialic acid. starting from n-acetylmannosamine, mannose or their chemically or enzymatical ... | 2006 | 17406495 |
| pasteurella multocida and its role in porcine pneumonia. | pasteurella multocida has been recognized as a contributor to debilitating and fatal porcine pneumonia for at least 120 years and there continues to be sustained, unabated high prevalence of the organism in cases submitted for diagnostic work up. understanding of its role in disease has been limited, in part because of difficulty in reproducing the disease experimentally with capsular type a strains of p. multocida, the predominant type associated with porcine pneumonia. this limitation has stym ... | 2006 | 17389051 |
| experimental transmission of pasteurella multocida 6:b in goats. | haemorrhagic septicaemia (hs) is an acute disease of cattle and buffaloes caused by pasteurella multocida 6:b. outbreaks of the disease have been closely associated with carrier animals that transmit the organism to susceptible animals during stressful condition. this study was conducted to determine whether goats exposed intranasally to p. multocida 6:b can transmit the organism to contact goats. thirty-six healthy local katjang goats were divided into four groups and goats of groups 1 and 3 we ... | 2007 | 17381677 |
| effect of ivermectin on the cellular and humoral immune responses of rabbits. | the objective of this paper is to determine the effect of ivermectin administration on cell mediated (cmi) and humoral immunity (hi) of rabbits. cmi against dinitrochlorobenzene (dncb) and sheep red blood cells (srbc) in rabbits was determined by delayed-type hypersensitivity and macrophage engulfment assay (mea), respectively; whereas, hi to pasteurella multocida b2 vaccine and srbc was determined by indirect haemagglutination assay (iha) and jerne hemolytic plaque formation assay (jhpfa), resp ... | 2007 | 17379254 |
| [evaluation of two techniques of molecular subtyping to study pasteurella multocida]. | typeability, reproducibility, and discriminatory power of eric-pcr and apal-pfge to establish the genetic relation of p. multocida strains were determined. forty-nine strains of different source, biotype, capsular group, somatic serotype, and resistance to antimicrobials were studied. by eric-pcr, 31 patterns were defined with 10 to 14 bands in a rank of 0.2 and 1.2 kb. by apal-pfge, 37 restriction patterns were established with 7 to 15 bands of 34 to 450 kb. typeability was 100% (t=1) for eric- ... | 2006 | 17373089 |
| mutations in 16s rrna and ribosomal protein s5 associated with high-level spectinomycin resistance in pasteurella multocida. | pasteurella multocida isolates with high-level spectinomycin resistance in which no adenyltransferase genes could be demonstrated exhibited a c1192g transversion in the 16s rrna of all six or five of the six rrna operons and/or two different types of 3-bp deletions in the rpse gene that codes for the ribosomal protein s5. | 2007 | 17371823 |
| fatal pasteurella multocida septicemia and necrotizing fasciitis related with wound licked by a domestic dog. | a 68-y-old male had necrotizing fasciitis and bacteremia due to pasteurella multocida. saliva culture from his dog grew p. multocida and pseudomonas aeruginosa. the human and dog p. multocida strains were of the same antibiogram but not identical tested with ribotyping. the wound licked by his dog was the only risk factor. | 2007 | 17366037 |
| successful treatment of pasteurella multocida meningitis with aztreonam. | this is the first reported case of the successful treatment of pasteurella multocida meningitis with aztreonam in a patient with multiple antibiotic allergies. | 2007 | 17366017 |
| crystal structures reveal a thiol protease-like catalytic triad in the c-terminal region of pasteurella multocida toxin. | pasteurella multocida toxin (pmt), one of the virulence factors produced by the bacteria, exerts its toxicity by up-regulating various signaling cascades downstream of the heterotrimeric gtpases gq and g12/13 in an unknown fashion. here, we present the crystal structure of the c-terminal region (residues 575-1,285) of pmt, which carries an intracellularly active moiety. the overall structure of c-terminal region of pmt displays a trojan horse-like shape, composed of three domains with a "feet"-, ... | 2007 | 17360394 |
| pasteurella multocida detection by 5' taq nuclease assay: a new tool for use in diagnosing fowl cholera. | a 5' taq nuclease assay utilising minor groove binder technology and targeting the 16s rrna gene was designed to detect pasteurella multocida (the causative agent of fowl cholera) in swabs collected from poultry. the assay was first evaluated using pure cultures. the assay correctly identified four p. multocida taxonomic type strains, 18 p. multocida serovar reference strains and 40 australian field isolates (17 from poultry, 11 from pigs and 12 from cattle). representatives of nine other pasteu ... | 2007 | 17346833 |
| detection of respiratory pathogens in porcine lung tissue and lavage fluid. | the objective of this study was to compare the detection rate of bacterial agents in bronchoalveolar lavage fluid (balf), taken without visual control, to that in affected lung tissue obtained from the same pig at necropsy. balf and affected lung tissue were examined for mycoplasma hyopneumoniae using pcr, and standard cultural methods were used for actinobacillus pleuropneumoniae, bordetella bronchiseptica, haemophilus parasuis, pasteurella multocida and streptococcus suis. all pigs with a hist ... | 2008 | 17339121 |
| pasteurella multocida sepsis, due to a scratch from a pet cat, in a post-chemotherapy neutropenic patient with non-hodgkin lymphoma. | pasteurella (p) multocida exists in a variety of animals and causes diverse infections in humans due to animal bites and scratches, usually by cats or dogs, and oral and respiratory infection. we report a case of p multocida sepsis due to a scratch from a pet cat, complicated with disseminated intravascular coagulation in a post-chemotherapy neutropenic patient with non-hodgkin lymphoma. the patient was a febrile 79-year-old woman with disturbed consciousness and subcutaneous abscess in her righ ... | 2007 | 17321993 |
| communicable disease and health protection quarterly review: july to september 2006. from the health protection agency. | 2007 | 17311831 | |
| [pneumonia with septicemia caused by pasteurella multocida in an immunocompetent patient]. | pneumonia with septicemia caused by pasteurella multocida was diagnosed in an immunocompetent patient exposed to a dog. this case is remarkable by two aspects: first the absence of visible cutaneous lesion, and second the localization and severity of the infection caused by p. multocida even though the patient was immunocompetent. p. multocida can cause respiratory and systemic infection, and it is a possible diagnosis in case of exposure to animals, even without history of bite or scratch. furt ... | 2007 | 17303362 |
| [influence of cultivation time and composition of growth medium on formation of capsule, quantity and immunological properties of pasteurella multocida capsular antigen]. | results of study of capsule formation and immunologic properties of capsular antigen of attenuated strain la-25 of pasteurella multocida grown on liquid medium from non-food materials and hottinger's broth depending on cultivation time are presented. | 2006 | 17297891 |
| isolated endocarditis of the pulmonary valve caused by pasteurella multocida. | we describe the rare case of a patient with an isolated endocarditis of the pulmonary valve caused by pasteurella multocida. the bacterium was cultured from blood as well as from the excised valve after pulmonary valve replacement. risk factors were contact with animals and concurrent intravenous drug use. | 2007 | 17297591 |