Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| [search for rna of the hepatitis e virus autochthonous for russia in the most likely infection sources]. | the research carried out for 30 years from the moment of hepatitis e virus (hev) discovery has proved the presence of the autochthonous hev in non-endemic areas: europe and russia. monitoring of the hev antibodies (anti-hev) among the russian population has revealed regions with increased seroprevalence that testifies to high probability of local hev infection in these areas. contact with hev can represent special danger for patients of the risk groups. in this work, the blood sera testing was c ... | 2014 | 25335410 |
| hepatitis e virus seroprevalence among hemodialysis and hemophiliac patients in tunisia (north africa). | the aims of this study are to determine seroprevalence of hepatitis e virus (hev) in tunisian blood donors and to evaluate its risk of parenteral transmission. sera collected from 426 blood donors were tested for hev igg by indirect elisa. individuals were recruited from two national transfusion centers, in the north and the south of the country. seroprevalence of hev igg was then compared with two other groups with increased risk of exposure to parenterally transmitted agents: 80 hemophiliac an ... | 2015 | 25331682 |
| quantitative proteomics identifies host factors modulated during acute hepatitis e virus infection in the swine model. | hepatitis e virus (hev) causes acute enterically transmitted hepatitis. in industrialized countries, it is a zoonotic disease, with swine being the major reservoir of human hev contamination. the occurrence and severity of the disease are variable, with clinical symptoms ranging from asymptomatic to self-limiting acute hepatitis, chronic infection, or fulminant hepatitis. in the absence of a robust cell culture system or small-animal models, the hev life cycle and pathological process remain unc ... | 2014 | 25320303 |
| prevalence of hepatitis e virus (hev) antibodies in serbian blood donors. | hepatitis e virus (hev) infection is rarely reported in industrialized countries, but recent studies have revealed quite variable seroprevalence rates among european populations, including blood donors. in serbia, very limited data about hev seroprevalence are available. this study aimed to determine the prevalence of anti-hev igg antibodies and hev rna in the sera of volunteer blood donors in serbia. | 2014 | 25313610 |
| hepatitis e virus genotypes 1 and 3 in wastewater samples in tunisia. | hepatitis e represents an important public-health concern throughout the world. it is one of the leading causes of hepatitis in north africa, asia and the middle east. in tunisia, the true burden of hev infection is still unknown. the objectives of the present study were to assess the occurrence of hepatitis e virus in tunisia through the monitoring of urban sewage and to characterize the strains identified using molecular assays. a total of 150 sewage samples (raw and treated) were collected fr ... | 2015 | 25307960 |
| extra-hepatic manifestations of autochthonous hepatitis e infection. | autochthonous (locally acquired) hepatitis e is increasingly recognised in developed countries, and is thought to be a porcine zoonosis. a range of extra-hepatic manifestations of hepatitis e infection have been described, but have never been systematically studied. | 2014 | 25303615 |
| hepatitis e infection in a renal transplant recipient. | an asymptomatic 35-year-old renal transplant recipient was noted to have deranged liver function tests. liver biopsy revealed a portal inflammatory process with mild lobular activity and portal fibrous expansion, consistent with a virally mediated process. an extensive viral screen confirmed infection with hepatitis e virus genotype 3 (hev-3). there is increased awareness about locally acquired hepatitis e virus (hev) infection in the transplant population in the uk. the important implications o ... | 2014 | 25295201 |
| phylogenetic analysis of hepatitis e virus in domestic swine and wild boar in germany. | hepatitis e virus (hev) is an emerging non-enveloped positive strand rna virus with worldwide distribution that can cause acute liver disease in humans. the virus has also been detected in both domestic and wild animals. in this study we investigated the presence of hev in free-living wild boar as well as in domestic swine. a total of 105 domestic swine fecal samples and 124 wild boar sera were tested for the presence of hev rna by rt-pcr. a 241 nucleotide (nt) fragment from the capsid gene of h ... | 2014 | 25287630 |
| serological and virological survey of hepatitis e virus in wild boar populations in northwestern italy: detection of hev subtypes 3e and 3f. | although rare in developed countries, most acquired human cases of hepatitis e virus (hev) infection are associated with travel to developing countries where hev is endemic. increasingly, however, sporadic, non-travel-related hev cases have been reported in developed countries. in italy, only two studies to date have investigated the presence of hev in wild boars. here, we report a serological and virological survey of hev in wild boar populations in northwestern italy. during the hunting season ... | 2015 | 25283611 |
| evidence of mapk-jnk1/2 activation by hepatitis e virus orf3 protein in cultured hepatoma cells. | hepatitis e virus (hev) has recently emerged to cause chronic infection in some immunosuppressed individuals, including extrahepatic manifestations in acute and chronic patients. mammalian mapk-jnk1/2 is expressed in hepatocytes, which is known to be involved in anti-apoptotic signaling pathway for the establishment of persistent infection. though in vitro modulation of cellular mapk-erk cascade by hev-orf3 protein is suggested to have a role in host pathobiology, activation of the jnk module ha ... | 2015 | 25280525 |
| chronic hepatitis e virus infection in a pediatric female liver transplant recipient. | we describe a case of chronic hepatitis e virus (hev) infection in a 13-year-old female liver transplant recipient with recurrent increased aminotransferase levels and acute cellular rejection. this finding demonstrates that chronic hev infection can occur and should be further investigated in immunocompromised patients in latin america. | 2014 | 25275004 |
| [hepatitis e virus: blood transfusion implications]. | hepatitis e virus (hev) is a non-enveloped rna virus transmitted by the fecal-oral route. autochthonous hepatitis e occurring in developed countries is caused by genotypes 3 and 4 and is a zoonotic infection. humans are infected mostly after ingestion of undercooked meat from infected animals. most hev 3 and 4 infections are clinically inapparent. however, genotype 3 (hev 3) can lead to chronic hepatitis in immuno-compromised patients such as organ-transplant recipients and patients with haemato ... | 2014 | 25267201 |
| lack of persistent hepatitis e virus infection as a cause for unexplained transaminase elevation in renal transplant recipients in india. | hepatitis e virus (hev) infection is highly endemic in india, being the most common cause of acute hepatitis; however, no case of chronic infection has been reported. all the human isolates of hev from india till date have belonged to genotype 1. in contrast, in non-endemic areas, genotype 3 is the most prevalent, and persistent hev infection has been reported among solid-organ transplant recipients. whether persistent infection occurs with genotype 1 hev is unclear. we therefore looked for evid ... | 2014 | 25266354 |
| chlorine inactivation of hepatitis e virus and human adenovirus 2 in water. | hepatitis e virus (hev) is transmitted via the fecal-oral route and has been recognized as a common source of large waterborne outbreaks involving contaminated water in developing countries. thus, there is the need to produce experimental data on the disinfection kinetics of hev by chlorine in water samples with diverse levels of fecal contamination. here, the inactivation of hev and human adenovirus c serotype 2 (hadv2), used as a reference virus, was monitored using immunofluorescence and quan ... | 2014 | 25252347 |
| protracted fecal shedding of hev during ribavirin therapy predicts treatment relapse. | twenty-four solid-organ-transplant recipients with chronic hepatitis e virus (hev) infections were given ribavirin therapy for 3 months. all the patients with protracted fecal hev shedding during treatment suffered a relapse. monitoring hev fecal excretion could be used to determine the optimal duration of ribavirin therapy. | 2015 | 25249523 |
| hepatitis e in germany--an under-reported infectious disease. | at least 17% of the population in germany has been infected with the hepatitis e virus (hev); thus, hev infections are more frequent than was previously assumed. however, fewer than 500 hev infections were reported to the robert koch institute in 2013. | 2014 | 25249359 |
| hepatitis e virus (hev) seroprevalence in the general population of the republic of korea in 2007-2009: a nationwide cross-sectional study. | hepatitis e virus (hev) is an emerging pathogen associated with endemic and acute viral hepatitis. in this study, we investigate the hev seroprevalence and putative risk factors by a nationwide cross-sectional study in the republic of korea. | 2014 | 25248488 |
| [feasibility of hev vaccine as control in hpv vaccine study and comparison of serological and risk factors between hev and hpv infection among females]. | investigating the distribution of anti-hepatitis e virus (hev-igg), anti-human papillomavirus (hpv l1-igg) and risk factors among female residents in xinmi county, to explore the influencing factors of hpv vaccine study using hev vaccinated population as a control. | 2014 | 25241795 |
| seroprevalence of hepatitis e virus infection in psychiatric patients and control subjects in shandong province, eastern china. | hepatitis e, caused by the hepatitis e virus (hev), is an important global public health concern. there are conflicting reports in regard to the association of hev infection and psychiatric disorders. therefore, we investigated this association in a chinese population through a case-control seroprevalence study. | 2014 | 25220239 |
| first detection of hepatitis e virus in central argentina: environmental and serological survey. | the hepatitis e virus (hev) is an emergent causative agent of acute hepatitis worldwide, transmitted by fecal-oral route. in argentina it is considered rare, so differential laboratory testing is not routinely performed. besides, in argentina's central area epidemiological and molecular characteristics of hev are still unknown. | 2014 | 25213209 |
| identification of an antigenic domain in the n-terminal region of avian hepatitis e virus (hev) capsid protein that is not common to swine and human hevs. | the antigenic domains located in the c-terminal 268 amino acid residues of avian hepatitis e virus (hev) capsid protein have been characterized. this region shares common epitopes with swine and human hevs. however, epitopes in the n-terminal 338 amino acid residues have never been reported. in this study, an antigenic domain located between amino acids 23 and 85 was identified by indirect elisa using the truncated recombinant capsid proteins as coating antigens and anti-avian hev chicken sera a ... | 2014 | 25209807 |
| [construction and investigation of a recombinant eukaryotic expression vector for expressing the orf3 protein of hepatitis e virus in bhk-21 fibroblasts]. | to construct a eukaryotic expression vector to express the hepatitis e virus protein open reading frame 3 (orf3) and investigate the intracellular location of the expressed protein using the baby hamster kidney (bhk-21) fibroblast cell line. | 2014 | 25203800 |
| [serum anti-hepatitis e virus igg antibody and risk factors among female residents of xinmi in henan province]. | to determine the distribution of anti-hepatitis e virus (hev) igg antibody and anti-human papilloma virus (hpv) igg antibody among female residents of xinmi and investigate the risk factors of hev infection. | 2014 | 25203701 |
| reply to "does chronic hepatitis e virus infection exist in immunocompetent patients?". | 2015 | 25203636 | |
| a population-based seroepidemiological study on hepatitis e virus in iran. | background little is known about hev seroprevalence and its determinants in iran. considering the fact that iran is among the countries in which hev infection is endemic, a large-scale population-based study in this regard is justified. methods this survey was conducted in 2006 in tehran and golestan provinces, iran. stored sera of subjects were tested for serological markers of anti-hev. the baseline data were recorded in structured questionnaires. weighted seroprevalence and weighted logistic ... | 2010 | 25197520 |
| the impact of hepatitis e in the liver transplant setting. | hepatitis e virus (hev) infection has been identified as a cause of graft hepatitis in liver transplant recipients. the true frequency and clinical importance of hev infections after liver transplantations is a matter of debate. it is proposed that consumption of hev-contaminated undercooked meat is a main source for hev infections in developed countries--which might also account for some hepatitis e cases after organ transplantation. however, hev is also transmitted by transfusion of blood prod ... | 2014 | 25195557 |
| a hospital-based retrospective study on frequency and distribution of viral hepatitis. | viral hepatitis is a major public health problem throughout the world. it is the inflammation of the liver due to the infection of any of the five main hepatic viruses a to e and it affects the liver through different modes of transmission. this study mainly aims at the frequency and distribution of viral hepatitis based on age and sex during a time period of 5 years. | 2014 | 25191049 |
| meeting report: 2013 pda virus & tse safety forum. | the report provides a summary of the presentations and discussions at the virus & tse safety forum 2013 organized by the parenteral drug association (pda) and held in berlin, germany, from june 4 to 6, 2013. the conference was accompanied by a workshop, "virus spike preparations and virus removal by filtration: new trends and developments". the presentations and the discussion at the workshop are summarized in a separate report that will be published in this issue of the journal as well. as with ... | 2016 | 25188343 |
| hepatitis e virus of subtype 3i in chronically infected kidney transplant recipients in southeastern france. | hepatitis e virus (hev) is a leading cause of waterborne acute hepatitis in developing countries. in europe, hev causes a zoonotic disease and is hyperendemic in southern france. four hev genotypes (1 to 4) have been defined, and the most used classification divides them into 24 subtypes. autochthonous european hev strains belong in majority to genotype 3. subtypes 3c, 3f, and 3e are representative of the hev diversity in france. hev causes chronic hepatitis in solid-organ transplant recipients ... | 2014 | 25187634 |
| genetic heterogeneity of swine hepatitis e virus isolates from yunnan province, china in 2011-2012. | hepatitis e is a disease of major public-health concern mainly in developing countries. although molecular and sero-epidemiological investigations of hev have been performed in many provinces in china, the epidemiological data from yunnan province are limited and genotypes are not be fully characterized. in this study the prevalence and characteristics of hepatitis e virus (hev) detected in pigs from yunnan province, china was evaluated. | 2014 | 25187005 |
| clinical profile, maternal and fetal outcomes of acute hepatitis e in pregnancy. | pregnant women are at increased risk of complications in hepatitis e virus (hev) infection, with the risk increasing as the pregnancy progresses, often leading to fulminant hepatic failure and adverse fetal outcome. | 2014 | 25184080 |
| a mutation in the hepatitis e virus rna polymerase promotes its replication and associates with ribavirin treatment failure in organ transplant recipients. | we analyzed blood samples collected from 15 patients with chronic hepatitis e who were recipients of solid-organ transplants. all patients cleared the hepatitis e virus (hev) except for 2 (nonresponders); 1 patient died. a g1634r mutation in viral polymerase was detected in the hev rna of the nonresponders; this mutation did not provide the virus with resistance to ribavirin in vitro. however, the mutant form of a subgenomic replicon of genotype 3 hev replicated more efficiently in vitro than he ... | 2014 | 25181691 |
| changes in the cellular proteins of a549 infected with hepatitis e virus by proteomics analysis. | our understanding of hepatitis e virus (hev) has changed enormously over the past 30 years, from a waterborne infection causing outbreaks of acute hepatitis in developing countries to an infection of global distribution causing a range of hepatic and extra-hepatic illness. however, the key proteins playing important parts in the virus infection were still unknown. understanding the changes of cellular proteins in these cells exposed to hev is helpful for elucidating molecular mechanisms associat ... | 2014 | 25175408 |
| detection of pathogenic viruses in sewage provided early warnings of hepatitis a virus and norovirus outbreaks. | most persons infected with enterically transmitted viruses shed large amounts of virus in feces for days or weeks, both before and after onset of symptoms. therefore, viruses causing gastroenteritis may be detected in wastewater, even if only a few persons are infected. in this study, the presence of eight pathogenic viruses (norovirus, astrovirus, rotavirus, adenovirus, aichi virus, parechovirus, hepatitis a virus [hav], and hepatitis e virus) was investigated in sewage to explore whether their ... | 2014 | 25172863 |
| seroprevalence of hepatitis e virus among pregnant women and control subjects in china. | hepatitis e infection, caused by the hepatitis e virus (hev), is an important global public health concern, with particularly high mortality in pregnant women. china is generally judged to be an hev-endemic area, but epidemiological data for hev among pregnant women are limited. between june 2011 and july 2013, a case-control study was conducted to estimate the seroprevalence and potential risk factors associated with the acquisition of hev infection by pregnant women in china. nine-hundred and ... | 2015 | 25164987 |
| hepatitis e in australian hiv-infected patients: an under-recognised pathogen? | background hepatitis e virus (hev) infection has been found to cause chronic hepatitis in hiv-infected patients. in australia, where hev is nonendemic, background seroprevalence is reportedly low but has not been evaluated in the hiv-infected population. the study aimed to assess the seroprevalence of hev in a cohort of hiv-infected patients with normal liver function and in another group with biochemical hepatitis. | 2014 | 25162285 |
| hepatitis e virus exposure in pregnant women in rural durango, mexico. | hepatitis e virus (hev) infection represents a risk for mortality in pregnant women. the seroepidemiology of hev infection in rural pregnant women in the americas is largely unknown. the aim of the study was to determine the seroepidemiology of anti-hev igg antibodies in rural pregnant women in durango, mexico. | 2015 | 25152983 |
| hepatitis e virus: chronic infection, extra-hepatic manifestations, and treatment. | hepatitis e virus (hev) infection is a worldwide disease. an improved understanding of the natural history of hev infection has been achieved within the last decade. several reservoirs and transmission modes have been identified. it is an underdiagnosed disease because of the use of low-sensitivity serological assays; however, diagnostics tools, including nucleic-acid tests, have improved. hev infection is usually an acute self-limiting disease, but causes chronic infection with rapidly progress ... | 2015 | 25150374 |
| hepatitis a and e seroprevalence and associated risk factors: a community-based cross-sectional survey in rural amazonia. | hepatitis a virus (hav) and hepatitis e virus (hev) are both transmitted by the faecal-oral route, and represent common causes of acute hepatitis in developing countries. the endemicity of hav infection has shifted from high to moderate in brazil. human cases of hev infection seem to be rare, although the virus has been detected in swine livestock and effluents of slaughterhouses. this study was to determine the epidemiology of hepatitis a and e in one of the largest agricultural settlements in ... | 2014 | 25149658 |
| pork consumption and seroprevalence of hepatitis e virus,thailand, 2007-2008. | the nationwide seroprevalence of hepatitis e igg was determined among young men in thailand. overall seroprevalence was 14% (95% ci 13%-15%); range by province was 3%-26%. seroprevalence was lowest in the south, an area predominantly occupied by persons of the islam religion, whose dietary laws proscribe pork. | 2014 | 25148245 |
| epidemiology of hepatitis e virus infection in patients on chronic hemodialysis. | many studies have been done on the epidemiology of hepatitis e on general population, but the data among patients with end stage renal disease (esrd) are few and give conflicting results. | 2014 | 25147715 |
| decline in hepatitis e virus antibody prevalence in the united states from 1988-1994 to 2009-2010. | previous population-based estimates in the united states have shown a relatively high prevalence of hepatitis e virus (hev) antibody. we sought to determine whether changes in the prevalence of hev antibody have occurred over time. | 2015 | 25147277 |
| clinical and molecular analyses of sporadic acute hepatitis a and e and the specific viral genotypes isolated in iwate and three neighboring prefectures in the northern part of honshu, japan, between 2004 and 2013. | to examine the prevalence and characteristics of hepatitis a virus (hav) and hepatitis e virus (hev) infections in the northern part of honshu, japan, during the last decade. | 2015 | 25146162 |
| early-life hepatitis e infection in pigs: the importance of maternally-derived antibodies. | passive immunity (pi), acquired through colostrum intake, is essential for piglet protection against pathogens. maternally-derived antibodies (mdas) can decrease the transmission of pathogens between individuals by reducing shedding from infected animals and/or susceptibility of naïve animals. only a limited number of studies, however, have been carried out to quantify the level of protection conferred by pi in terms of transmission. in the present study, an original modeling framework was desig ... | 2014 | 25144763 |
| crystal structure of a nematode-infecting virus. | orsay, the first virus discovered to naturally infect caenorhabditis elegans or any nematode, has a bipartite, positive-sense rna genome. sequence analyses show that orsay is related to nodaviruses, but molecular characterizations of orsay reveal several unique features, such as the expression of a capsid-δ fusion protein and the use of an atg-independent mechanism for translation initiation. here we report the crystal structure of an orsay virus-like particle assembled from recombinant capsid p ... | 2014 | 25136116 |
| acute fulminant hepatitis e virus genotype 3e infection: description of the first case in europe. | hepatitis e virus (hev) is the most important causative agent of acute hepatitis in developing countries. the disease is usually characterized by a self-limiting, benign course. however, when particular conditions coexist (pregnancy, old age, pre-existing liver disease) it may run an unfavourable course. to date, 4 hev genotypes have been described. historically, in the western world, hev infection was considered a travel-related disease, however in the last 2 decades a great number of non-trave ... | 2014 | 25134653 |
| safety measures to prevent hepatitis e virus transmission by blood transfusion. | 2014 | 25130335 | |
| mode of swine hepatitis e virus infection and replication in primary human hepatocytes. | the aim of this study was to investigate the infection and replication of swine-derived hepatitis e virus (hev) in primary cultured human hepatocytes (phcs). hepatocytes were cultured from the resected normal livers of patients with metastatic tumours. these cultured hepatocytes were infected with swine-derived genotype 3 or 4 hev. viral replication was monitored using reverse transcriptase-quantitative pcr. the amount of hev rna increased in the culture media and cells following infection. immu ... | 2014 | 25114028 |
| evaluation of viral inactivation of pseudorabies virus, encephalomyocarditis virus, bovine viral diarrhea virus and porcine parvovirus in pancreatin of porcine origin. | pancreatin is a substance containing enzymes, principally amylase, lipase, and protease. it is obtained from bovine or porcine pancreas and used in the treatment of pancreatic endocrine insufficiency in humans. regulations and safety concerns mandate viral clearance (virus removal or inactivation) in biopharmaceuticals such as pancreatin. a virus validation study was performed to evaluate virus clearance achieved in the final step of drying under vacuum by testing a panel of four animal viruses: ... | 2014 | 25110118 |
| hepatitis e virus inhibits type i interferon induction by orf1 products. | hepatitis e virus (hev) causes both endemic and epidemic human hepatitis by fecal-oral transmission in many parts of the world. zoonotic transmission of hev from animals to humans has been reported. due to the lack of an efficient cell culture system, the molecular mechanisms of hev infection remain largely unknown. in this study, we found that hev replication in hepatoma cells inhibited poly(i·c)-induced beta interferon (ifn-β) expression and that the hev open reading frame 1 (orf1) product was ... | 2014 | 25100852 |
| characterization of the polyproline region of the hepatitis e virus in immunocompromised patients. | little is known about virus adaptation in immunocompromised patients with chronic genotype 3 hepatitis e virus (hev3) infections. virus-host recombinant strains have been isolated recently from chronically infected patients. the nature and incidence of such recombinant events occurring during infections of solid-organ transplant (sot) recipients are essentially unknown. the polyproline region (ppr) of strains isolated from sot patients was sequenced during the acute-infection phase (n = 59) and ... | 2014 | 25100839 |
| novel molecular alterations in the orf 2 capsid gene of hepatitis e virus in patients with acute liver failure in north india. | hepatitis e virus (hev) is evolving as a major global threat to public health, including in developed countries. we partially sequenced the orf 2 capsid protein genes of hev genomes from patients with acute liver failure, including pregnant women in the northern part of india. five unique synonymous substitutions and one non-synonymous substitution, along with a novel mutation, p259s, in the capsid gene, were identified that might be associated with the poor outcome in the patients. phylogenetic ... | 2014 | 25100237 |
| hepatitis e virus in blood components: a prevalence and transmission study in southeast england. | the prevalence of hepatitis e virus (hev) genotype 3 infections in the english population (including blood donors) is unknown, but is probably widespread, and the virus has been detected in pooled plasma products. hev-infected donors have been retrospectively identified through investigation of reported cases of possible transfusion-transmitted hepatitis e. the frequency of hev transmission by transfusion and its outcome remains unknown. we report the prevalence of hev rna in blood donations, th ... | 2014 | 25078306 |
| hepatitis e virus infection in farmed rabbits and swine in the eastern chinese city lianyungang: showing no potential interspecies transmission. | rabbit hev isolated recently from farmed rabbits in china has been shown experimentally to be able to infect both cynomolgus macaques and pigs. the purpose of the present study was to investigate the extent to which cross-species transmission of rabbit hev in farm settings is a significant factor in the spread of this zoonotic infection. rabbit and swine feces were collected from the same area in eastern china (lianyungang city) and analyzed by rt-pcr. partial genome sequencing of a 365 bp regio ... | 2014 | 25069969 |
| cirrhosis, liver transplantation and hiv infection are risk factors associated with hepatitis e virus infection. | acute and chronic hepatitis e have been associated with high mortality and development of cirrhosis, particularly in solid-organ recipients and patients infected by human immunodeficiency virus. however, data regarding the epidemiology of hepatitis e in special populations is still limited. | 2014 | 25068388 |
| hepeviridae: an expanding family of vertebrate viruses. | the hepatitis e virus (hev) was first identified in 1990, although hepatitis e-like diseases in humans have been recorded for a long time dating back to the 18th century. the hev genotypes 1-4 have been subsequently detected in human hepatitis e cases with different geographical distribution and different modes of transmission. genotypes 3 and 4 have been identified in parallel in pigs, wild boars and other animal species and their zoonotic potential has been confirmed. until 2010, these genotyp ... | 2014 | 25050488 |
| mtor-inhibitors may aggravate chronic hepatitis e. | 2014 | 25046849 | |
| hepatitis e genotype 4 virus from feces of monkeys infected experimentally can be cultured in plc/prf/5 cells and upregulate host interferon-inducible genes. | the understanding of the interaction between hepatitis e virus (hev) and its host cells has been impeded greatly by the absence of a cell culture system. in this study, an efficient cultivation method was developed in plc/prf/5 cells for hev genotype 4 from the feces of monkeys infected experimentally. compared to minimal essential medium (mem), mixed dulbecco's modified eagle's medium (dmem)/m199 improved the infection efficiency of hev in plc/prf/5 cells. the incubation time and temperature we ... | 2014 | 25042677 |
| rare case of transfusion-transmitted hepatitis e from the blood of a donor infected with the hepatitis e virus genotype 3 indigenous to japan: viral dynamics from onset to recovery. | the transfusion transmission of hepatitis e can occur even in non-endemic areas in the world as autochthonous hepatitis e has been increasingly reported in developed countries where the hepatitis e virus (hev) is not prevalent. we investigated the post-transfusion transmission of hepatitis e in a patient by molecularly confirming its presence, and characterized the viral kinetics of hev in this case. | 2015 | 25041213 |
| seroprevalence study of hepatitis e virus infection in two districts of the czech republic. | the aim of this work was to retrospectively examine serum samples from 230 people living in two districts in the czech republic in year 1989 (znojmo and jihlava) for the igg antibodies against hepatitis e virus (hev). for examination, commercial elisa kit dia.pro was used and 13 seropositive persons were found, i.e. 5.7% of those examined. the seropositivity rate was higher in women (6.8%) than in men (3.7%), but the difference was not statistically significant. the age of examined persons did n ... | 2014 | 25025670 |
| hepatitis e virus in patients with acute severe liver injury. | to examine the incidence of hepatitis e (hepe) in individuals with acute liver injury severe enough to warrant treatment at a transplant unit. | 2014 | 25018853 |
| hepatitis viruses and liver transplantation: evolving trends in antiviral management. | viral hepatitis is both a leading indication for liver transplant (lt) and an important cause of posttransplant graft loss and mortality. treatment and prevention of hepatitis b virus in lt recipients, with the observed corresponding improvement in post-lt outcomes, is among the great success stories in transplantation. by comparison, treatment of hepatitis c virus with safe and effective regimens is only just becoming a reality. chronic hepatitis e virus infection in lt recipients represents a ... | 2014 | 25017077 |
| enteric porcine viruses in farmed shellfish in denmark. | bivalve shellfish are at constant risk of being exposed to pathogens as a consequence of contamination of the shellfish beds with human or animal waste originating from sewage treatment plants or slurry fertilized fields. consumption of contaminated oysters and mussels are frequently reported as causes of disease outbreaks caused by norovirus or hepatitis a virus. other zoonotic pathogens such as hepatitis e virus (hev), rotavirus (rv) and salmonella from livestock may also be transmitted to she ... | 2014 | 25016209 |
| acute hepatitis after starting pinaverium bromide in a patient taking mirtazapine. | a 56-year-old man presented with chronic abdominal pain. he had been evaluated extensively in the recent past undergoing upper gastrointestinal endoscopy, colonoscopy and ct scan of the abdomen with normal results. the provisional diagnosis of irritable bowel syndrome was performed and pinaverium bromide was started. the patient had pre-existing hypertension, a major depressive disorder and gastro-oesophageal reflux disease. he had been taking nebivolol and pantoprazole for several years and mir ... | 2014 | 25015163 |
| chronic hepatitis e virus infection following allogeneic hematopoietic stem cell transplantation: an important differential diagnosis for graft versus host disease. | 2015 | 25015055 | |
| comparison of three in-house elisas for the detection of hepatitis e virus infection in pigs under field conditions. | hepatitis e virus (hev) is a rna non-enveloped virus that comprises four genotypes. the genome of hev is organized into three open reading frames (orfs), and the orf2 is responsible for encoding capsid proteins. hev can infect a wide range of hosts, and pigs are considered the main reservoir. hev infection is considered a zoonosis and it is responsible for acute hepatitis in humans, especially in developing countries. the development of a blocking elisa would be of high value for screening purpo ... | 2014 | 25010789 |
| identification and characterization of avian hepatitis e virus in 2013 outbreaks of hepatitis-splenomegaly syndrome in two us layer operations. | two commercial midwestern egg-type chicken flocks experienced significant increases in mortality rates in april 2013 with clinical signs appearing in 17-week-old pullets on farm a and in 46-week-old hens on farm b. average weekly mortality was 0.44% over a 4-week period on farm a and 0.17% over an 8-week period on farm b. on farm a, flocks in the affected house had a 45% decrease in daily egg production from weeks 19 to 27 when compared with standard egg production curves (p < 0.01) while no dec ... | 2014 | 25010035 |
| [prokaryotic expression and characterization of truncated mutant capsid protein of genotype iv hepatitis e virus]. | a truncated mutant of the open reading frame 2 (orf2, aa384-606) was amplified from cdna of genotype iv hepatitis e virus (hev) by polymerase chain reaction (pcr), subcloned to expression plasmid pto-t7, and expressed in escherichia coli. sds-page and western blotting were used to detect and identify the recombinant protein, namely rp24. after washing of inclusion bodies, dissolving in denaturing agents, refoldeding by dialysis, ion exchange chromatography and gel chromatography, dynamic light s ... | 2014 | 25007574 |
| hepatitis e in patients with hepatic disorders and hiv-infected patients in croatia: is one diagnostic method enough for hepatitis e diagnosis? | we assessed hepatitis e virus (hev) seroprevalence in patients with hepatic disorders as well as in human immunodeficiency virus (hiv)-infected patients and emphasised the issue of possible non-specific anti-hev seroresponse and need for combining diagnostic methods for hepatitis e diagnosis. over a two-year period, from march 2011 to february 2013, we determined anti-hev immunoglobulin m (igm) and igg by enzyme immunoassays (eia; mikrogen, germany) in 504 hepatitis patients negative for acute v ... | 2014 | 25005459 |
| first report of hepatitis e virus circulation in domestic pigs in nigeria. | hepatitis e virus (hev) is an important cause of acute hepatitis in humans. zoonotic transmission between pigs and humans has been confirmed. human hev infection is common in nigeria; however, characterization of hev infection in other species was lacking. the objective of this study was to investigate hev infection in nigerian pigs. a total of 286 serum samples from six states in nigeria were tested for presence of anti-hev igg. ninety fecal samples from one of these states (plateau state) were ... | 2014 | 25002299 |
| first case report of an acute hepatitis e subgenotype 3c infection during pregnancy in germany. | hepatitis e is usually a self-limiting disease and an important cause of acute hepatitis in endemic countries in asia and africa. however, the mortality rate for pregnant women infected with hepatitis e virus (hev) in this area is about 25%. in germany, sporadic cases of acute hepatitis e infections have been described and the number of autochthonous infections is increasing. here we report an autochthonous hev subgenotype 3c infection in a 27-year old pregnant woman. this is the first documente ... | 2014 | 24996764 |
| hepatitis e virus seroprevalence in the united states: no easy answers. | 2015 | 24995930 | |
| hepatitis e virus seroprevalence in the national health and nutrition examination survey: facts trump opinion. | 2015 | 24995541 | |
| consensus proposals for classification of the family hepeviridae. | the family hepeviridae consists of positive-stranded rna viruses that infect a wide range of mammalian species, as well as chickens and trout. a subset of these viruses infects humans and can cause a self-limiting acute hepatitis that may become chronic in immunosuppressed individuals. current published descriptions of the taxonomical divisions within the family hepeviridae are contradictory in relation to the assignment of species and genotypes. through analysis of existing sequence information ... | 2014 | 24989172 |
| consensus proposals for classification of the family hepeviridae. | the family hepeviridae consists of positive-stranded rna viruses that infect a wide range of mammalian species, as well as chickens and trout. a subset of these viruses infects humans and can cause a self-limiting acute hepatitis that may become chronic in immunosuppressed individuals. current published descriptions of the taxonomical divisions within the family hepeviridae are contradictory in relation to the assignment of species and genotypes. through analysis of existing sequence information ... | 2014 | 24989172 |
| branched-linear and agglomerate protein polymers as vaccine platforms. | many viral structural proteins and their truncated domains share a common feature of homotypic interaction forming dimers, trimers, and/or oligomers with various valences. we reported previously a simple strategy for construction of linear and network polymers through the dimerization feature of viral proteins for vaccine development. in this study, technologies were developed to produce more sophisticated polyvalent complexes through both the dimerization and oligomerization natures of viral an ... | 2014 | 24985736 |
| occurrence of hepatitis e virus infection in acute hepatitis in thailand. | hepatitis e virus (hev) infection is one of the enterically transmitted types of hepatitis. the present study was undertaken to estimate the occurrence of hev infection in sporadic acute hepatitis in thailand. serum samples were obtained from 614 suspected acute hepatitis patients at two large hospitals in bangkok during 2008, 2009, and 2011. acute hepatitis e was identified by the presence of anti-hev igm (4.8%) using indirect elisa kits and/or hev rna (4.5%) by a semi-nested reverse transcript ... | 2014 | 24984976 |
| assessment of airborne virus contamination in wastewater treatment plants. | occupational exposure to bioaerosols in wastewater treatment plants (wwtp) and its consequence on workers' health are well documented. most studies were devoted to enumerating and identifying cultivable bacteria and fungi, as well as measuring concentrations of airborne endotoxins, as these are the main health-related factors found in wwtp. surprisingly, very few studies have investigated the presence and concentrations of airborne virus in wwtp. however, many enteric viruses are present in wast ... | 2014 | 24981824 |
| hepatitis e virus seroprevalence among blood donors in jiangsu province, east china. | hepatitis e virus (hev) infection is responsible for over 50% of acute viral hepatitis cases, and the blood transfusion route has emerged as a possible means of sporadic hev infection. the aim of this study was to determine the seroprevalence of hev among blood donors in east china. | 2014 | 24981426 |
| incidence and natural history of hepatitis e virus coinfection among hiv-infected patients. | to know the prevalence, incidence and factors associated with hepatitis e virus (hev) infection in hiv-infected individuals in spain, as well as to provide information on the natural history of hiv/hev coinfection. | 2014 | 24979724 |
| hepatitis e virus infection in hematopoietic stem cell transplant recipients. | recipients of allogeneic stem cell transplantations are at risk of acquiring acute hepatitis e virus (hev) infection, leading to chronicity. we review the incidence, sequela, extrahepatic manifestations, and treatment of hepatitis due to hev infection in allogeneic hematopoietic stem cell transplantation (allohsct) recipients. | 2014 | 24977683 |
| chronic hepatitis e in solid-organ transplantation: the key implications of immunosuppressants. | solid-organ recipients infected with hepatitis e virus (hev) bear an extremely high risk of developing chronic hepatitis, although this virus only causes acute infection in the general population. immunosuppressive medication universally used after transplantation to prevent organ rejection appears to be a main risk factor for developing chronic infection. this review aims to overview and emphasize the current clinical and experimental evidence regarding the key implications of immunosuppressant ... | 2014 | 24977682 |
| seroepidemiology of hepatitis e virus infection in general population in rural durango, mexico. | the seroepidemiology of hepatitis e virus (hev) infection in rural areas in mexico has been poorly studied. | 2014 | 24976837 |
| seroprevalence and evolutionary dynamics of genotype 4 hepatitis e virus in shandong province, china. | to investigate the seroprevalence and evolutionary dynamics of hepatitis e virus (hev) and assess the ancestor of hevs in china's shandong province. | 2014 | 24976732 |
| estimation of hepatitis e virus (hev) pig seroprevalence using elisa and western blot and comparison between human and pig hev sequences in belgium. | zoonotic transmission of hepatitis e virus (hev) is of special concern, particularly in high income countries were waterborne infections are less frequent than in developing countries. high hev seroprevalences can be found in european pig populations. the aims of this study were to obtain prevalence data on hev infection in swine in belgium and to phylogenetically compare belgian human hev sequences with those obtained from swine. an elisa screening prevalence of 73% (95% ci 68.8-77.5) was deter ... | 2014 | 24975642 |
| genetic characterization and serological prevalence of swine hepatitis e virus in shandong province, china. | hepatitis e virus (hev), the causative agent of hepatitis e, is classified into four major genotypes (1 to 4) and swine is the main natural reservoir for genotypes 3 and 4. in this study, a total of 106 bile samples from a slaughterhouse in the shandong province of china were tested for the partial orf2 gene of hev by rt-npcr to determine the virus genotypes, and two indirect elisa were developed for the detection of swine hev specific igm and igg antibodies in 980 serum samples from 24 farms, i ... | 2014 | 24975641 |
| hepatitis e virus seroprevalence in haemodialysis patients in zanjan province, islamic republic of iran. | hepatitis e virus (hev) infection is the most common form of acute hepatitis in adults in endemic regions of asia. in a descriptive, cross-sectional study, anti-hev antibody was measured in patients referred to the 2 haemodialysis centres in zanjan city, islamic republic of iran. among 93 patients with chronic renal failure, mean age 57.0 (sd 18.5) years, antibodies against hev were positive in 25 (26.9%) patients. hev infection was not significantly associated with sex, age, educational level, ... | 2013 | 24975304 |
| hepatitis e virus and fulminant hepatitis--a virus or host-specific pathology? | fulminant hepatitis is a rare outcome of infection with hepatitis e virus. several recent reports suggest that virus variation is an important determinant of disease progression. to critically examine the evidence that virus-specific factors underlie the development of fulminant hepatitis following hepatitis e virus infection. | 2015 | 24974734 |
| hepatitis e virus egress depends on the exosomal pathway, with secretory exosomes derived from multivesicular bodies. | our previous studies indicated that hepatitis e virus (hev) forms membrane-associated particles in the cytoplasm, most likely by budding into intracellular vesicles, and requires the multivesicular body (mvb) pathway to release virus particles, and the released hev particles with a lipid membrane retain the trans-golgi network protein 2 on their surface. to examine whether hev utilizes the exosomal pathway to release the virus particles, we analysed whether the virion release from plc/prf/5 cell ... | 2014 | 24970738 |
| transmission, diagnosis, and management of hepatitis e: an update. | hepatitis e virus (hev) infection is an important public health concern in many developing countries, causing waterborne outbreaks as well as sporadic autochthonous hepatitis. hev is mainly transmitted by the fecal-oral route in endemic areas through drinking of contaminated water. however, zoonotic transmission from animal reservoirs to humans has also been suggested. three additional routes of hev transmission have been proposed to occur: blood borne, human to human, and vertical transmission ... | 2014 | 24966702 |
| hepatitis e rorf2p stimulated and unstimulated peripheral expression profiling in patients with self-limiting hepatitis e infection. | to improve the current knowledge on the involvement of peripheral lymphocytes in hepatitis e virus (hev) associated pathogenesis, we analyzed alterations in (1) immunophenotypic expressions (by flow cytometry) and (2) gene expression patterns (by taqman low density array) of activatory, inhibitory, integrin, homing, ectonucleotidase machinery, costimulatory, inflammatory markers, and t regulatory cells (treg) associated cytokines on hev rorf2p stimulated and unstimulated pbmcs of 43 acute hev pa ... | 2014 | 24963498 |
| epidemiological investigation of the jaundice outbreak in lalkuan, nainital district, uttarakhand. | in march 2013, cases of acute hepatitis were reported from lalkuan, nainital district. we investigated the outbreak to identify the source of infection and to facilitate control measures. | 2014 | 24963225 |
| open reading frame 3 of genotype 1 hepatitis e virus inhibits nuclear factor-κappa b signaling induced by tumor necrosis factor-α in human a549 lung epithelial cells. | hepatitis e virus (hev) is one of the primary causative agents of acute hepatitis, and represents a major cause of severe public health problems in developing countries. the pathogenesis of hev is not well characterized, however, primarily due to the lack of well-defined cell and animal models. here, we investigated the effects of genotype 1 hev open reading frame 3 (orf3) on tnf-α-induced nucleus factor-κappa b (nf-κb) signaling. human lung epithelial cells (a549) were transiently transfected w ... | 2014 | 24959724 |
| hepatic flares in chronic hepatitis c: spontaneous exacerbation vs hepatotropic viruses superinfection. | the hepatitis c virus (hcv) causes an acute infection that is frequently asymptomatic, but a spontaneous eradication of hcv infection occurs only in one-third of patients. the remaining two-thirds develop a chronic infection that, in most cases, shows an indolent course and a slow progression to the more advanced stages of the illness. nearly a quarter of cases with chronic hepatitis c (chc) develop liver cirrhosis with or without hepatocellular carcinoma. the indolent course of the illness may ... | 2014 | 24944463 |
| ribavirin for chronic hepatitis e virus infection. | 2014 | 24941186 | |
| ribavirin for chronic hepatitis e virus infection. | 2014 | 24941185 | |
| ribavirin for chronic hepatitis e virus infection. | 2014 | 24941184 | |
| ribavirin for chronic hepatitis e virus infection. | 2014 | 24941183 | |
| spf rabbits infected with rabbit hepatitis e virus isolate experimentally showing the chronicity of hepatitis. | this study focused on investigating the pathogenesis seen in specific-pathogen-free (spf) rabbits following infection with a homologous rabbit hev isolate (chn-bj-rb14) and comparing it to that seen following infection with a heterologous swine genotype 4 hev isolate (chn-xj-sw13). three of the four animals inoculated with the homologous rabbit hev became infected, exhibiting an intermittent viremia, obvious fluctuations of liver function biomarkers alanine aminotransferase (alt) and aspartate a ... | 2014 | 24937350 |
| naturally occurring animal models of human hepatitis e virus infection. | hepatitis e virus (hev) is a single-stranded, positive-sense rna virus in the family hepeviridae. hepatitis e caused by hev is a clinically important global disease. there are currently four well-characterized genotypes of hev in mammalian species, although numerous novel strains of hev likely belonging to either new genotypes or species have recently been identified from several other animal species. hev genotypes 1 and 2 are limited to infection in humans, whereas genotypes 3 and 4 infect an e ... | 2014 | 24936039 |