Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| human papillomavirus dna and oncogene alterations in colorectal tumors. | the aim of the present study is to determine the presence and molecular integrity of high-risk hpv types in colorectal adenocarcinomas and to assess whether viral dna is related to common proto-oncogene alterations, such as k-ras mutations and c-myc gene amplification, in colorectal cancer. seventy-five colorectal adenocarcinomas were screened for hpv infection using nested-pcr (my09/11-gp5+/6+). hpv typing was performed by type-specific pcr for hpv 16 and hpv 18 dna. unidentified samples were s ... | 2010 | 20232185 |
| research on cancer prevention, detection and management in low- and medium-income countries. | the burden of cancer in low- and medium-income countries (lmic) is expected to increase in the next decades. the application of current knowledge and results of research in key areas would contribute to limit the impact of this phenomenon. opportunities for research on cancer prevention in lmic include investigating specific circumstances of exposure to known carcinogens and to agents which are not prevalent in other regions, as well as interactions among carcinogens and between genetic and envi ... | 2010 | 20231304 |
| model-based estimation of viral transmissibility and infection-induced resistance from the age-dependent prevalence of infection for 14 high-risk types of human papillomavirus. | viral transmissibility and natural resistance to infection are key determinants in assessing the population impact of human papillomavirus (hpv) vaccination, yet information on these parameters is scarce. using data from 2 large-scale surveys on sexual behavior in the netherlands (carried out in 2005-2006), the authors employed a bayesian framework to fit a transmission model to the cross-sectional age-dependent prevalence of hpv dna in cervical smears (data collected in 1992-2002), assuming tha ... | 2010 | 20231211 |
| empirically evaluating decision-analytic models. | model-based cost-effectiveness analyses support decision-making. to augment model credibility, evaluation via comparison to independent, empirical studies is recommended. | 2010 | 20230547 |
| hpv testing on self collected cervicovaginal lavage specimens as screening method for women who do not attend cervical screening: cohort study. | to determine whether offering self sampling of cervicovaginal material for high risk human papillomavirus (hpv) testing is an effective screening method for women who do not attend regular cervical screening programmes. | 2010 | 20223872 |
| abnormal anal cytology in hiv-infected women. | the purpose of this study was to assess the prevalence of and risk factors for abnormal anal cytology and human papillomavirus (hpv) infections in women who are human immunodeficiency virus (hiv) positive. | 2010 | 20223443 |
| [human papillomavirus infections in urology]. | 2010 | 20223127 | |
| developments in therapeutic human papillomavirus vaccination. | much progress has been made in the prevention and therapy of premalignant and malignant dysplasia caused by human papillomavirus by encouraging screening programs and recently by introducing preventive vaccines. to further reduce the worldwide burden of hpv-associated cancer supplementation of the established therapies with immunotherapeutic methods would have the potential for significant impact. dysplastic epithelial lesions and cancer of the anogenital and the oropharyngeal region show strong ... | 2009 | 20218099 |
| the location of endogenous wild-type p53 protein in 293t and hek293 cells expressing low-risk hpv-6e6 fusion protein with gfp. | the mechanism underlining human papillomaviruses (hpvs) causing cancer has been studied extensively, and it was concluded that the high-risk hpvs' e6 targeted and degraded tumor suppressor protein p53, leading to infected cells malignant transformation. in contrast, the low-risk hpvs only cause proliferative but non-invasive lesions of infected epithelia. therefore, we hypothesized that low-risk hpvs' e6 might interact with p53 in a different pattern. we used a mammalian green fluorescent protei ... | 2010 | 20213049 |
| a c-terminal hydrophobic, solvent-protected core and a flexible n-terminus are potentially required for human papillomavirus 18 e7 protein functionality. | the oncogenic potential of the high-risk human papillomavirus (hpv) relies on the expression of genes specifying the e7 and e6 proteins. to investigate further the variation in oligomeric structure that has been reported for different e7 proteins, an hpv-18 e7 cloned from a hispanic woman with cervical intraepithelial neoplasia was purified to homogeneity most probably as a stable monomeric protein in aqueous solution. we determined that one zinc ion is present per hpv-18 e7 monomer by amino aci ... | 2010 | 20211680 |
| parental acceptance of a mandatory human papillomavirus (hpv) vaccination program. | the objective of this study was to determine factors that influence parent's acceptance of a mandatory school-based human papillomavirus (hpv) vaccination program. | 2010 | 20207933 |
| the quality of life of patients with genital warts: a qualitative study. | genital warts, which are caused by infection with human papillomavirus (hpv), are one of the most common sexually transmitted diseases in europe. although genital warts are commonly perceived as a non-serious condition, treatment is often long, of varying effectiveness and the recurrence rate is high. very few studies have been performed on the personal consequences of genital warts. the aim of this qualitative study, set in denmark, was to examine the ways in which genital warts may affect pati ... | 2010 | 20205944 |
| the impact of intolerance of uncertainty on anxiety after receiving an informational intervention about hpv: a randomised controlled study. | this study examined the impact of intolerance of uncertainty (iu) and an informational intervention about human papillomavirus (hpv) infection on perceived uncertainty about one's hpv testing status (referred to as 'hpv uncertainty') and anxiety. iu, hpv uncertainty and other pre-intervention measures were assessed through mailed questionnaires. participants were then randomly assigned to receive either a long (n = 125) or short (n = 124) hpv-specific information pamphlet or a long (n = 131) or ... | 2010 | 20204959 |
| prophylactic human papillomavirus vaccines: will they do their job? | the prophylactic hpv l1 virus like particle vaccines are highly efficacious preventing >98% of hpv 16/18 caused high grade cervical intra-epithelial neoplasia (cin2/3) according to protocol group in phase iii randomized clinical trials over approximately 4 years. data from the trials together with postvaccine surveillance indicates that they have a good safety profile. as the current hpv vaccines include only two of the 15 oncogenic hpvs, they will not eliminate cervical cancer or the other hpv ... | 2010 | 20201919 |
| immunotherapy for cervical cancer: research status and clinical potential. | the high-risk types of human papillomavirus (hpv) have been found to be associated with most cervical cancers and play an essential role in the pathogenesis of the disease. despite recent advances in preventive hpv vaccine development, such preventive vaccines are unlikely to reduce the prevalence of hpv infections within the next few years, due to their cost and limited availability in developing countries. furthermore, preventive hpv vaccines may not be capable of treating established hpv infe ... | 2010 | 20199126 |
| [preparation of human papillomavirus 16 e7 peptide vaccine and its effectiveness in vitro and in vivo.]. | to prepare the human papillomavirus (hpv) 16 peptide vaccine and explore the effect in vitro and in vivo. | 2009 | 20193416 |
| [a 1:2 matched case-control study on the interaction of hpv16e6 and hla-dr9 allele to esophageal cancer in kazakh ethnicity, xinjiang]. | to evaluate the role and the association between hpv16e6 infection and hla-dr9 immune-associated gene to esophageal cancer (ec) in kazakh of xinjiang, china. | 2009 | 20193235 |
| detection of high risk human papillomavirus cervical infections by the hybrid capture in asunción, paraguay. | cervical cancer is the most frequent malignant tumour of women in latin america being human papillomavirus (hpv) the main cause. the aim of this study was to increase the knowledge about the cervical infections with oncogenic hpv types (hr-hpv) in asuncion, paraguay. two hundred and seventy-two cervical samples were analyzed using hybrid capture ii assay (hca ii) for hr-hpv. the frequency of hr-hpv in the study group was 44%. hr-hpv was detected in 25% of the women negative for squamous intraepi ... | 2009 | 20191197 |
| safety and immunogenicity of one dose of menacwy-crm, an investigational quadrivalent meningococcal glycoconjugate vaccine, when administered to adolescents concomitantly or sequentially with tdap and hpv vaccines. | this phase iii study evaluates an investigational quadrivalent meningococcal crm(197) conjugate vaccine, menacwy-crm (novartis vaccines), when administered concomitantly or sequentially with two other recommended adolescent vaccines; combined tetanus, reduced diphtheria and acellular pertussis (tdap), and human papillomavirus (hpv) vaccine. in this single-centre study, 1620 subjects 11-18 years of age, were randomized to three groups (1:1:1) to receive menacwy-crm concomitantly or sequentially w ... | 2010 | 20189491 |
| [human papillomavirus type 16- associated primary squamous cell carcinoma of the rectum following cervical intraepithelial neoplasia.] | 2011 | 20189202 | |
| comparison of human papillomavirus in situ hybridization and p16 immunohistochemistry in the detection of human papillomavirus-associated head and neck cancer based on a prospective clinical experience. | human papillomavirus (hpv) is a causative agent in a subset of head and neck squamous cell carcinomas (hnsccs). these hpv-related cancers have a clinicopathologic profile that diverges from hpv-negative hnsccs. accordingly, hpv testing may soon become integrated into standard pathologic assessment of hnsccs. | 2010 | 20186832 |
| anomalous dna binding by e2 regulatory protein driven by spacer sequence tata. | we have investigated the anomalously weak binding of human papillomavirus (hpv) regulatory protein e2 to a dna target containing the spacer sequence tata. experiments in magnesium (mg(2+)) and calcium (ca(2+)) ion buffers revealed a marked reduction in cutting by dnase i at the cpg sequence in the protein-binding site 3' to the tata spacer sequence, studies of the cation dependence of dna-e2 affinities showed that upon e2 binding the tata sequence releases approximately twice as many mg(2+) ions ... | 2010 | 20185566 |
| anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from germany. | anal intraepithelial neoplasia (ain), a human papillomavirus (hpv)-associated potential precursor lesion of anal cancer, is frequent among human immunodeficiency virus (hiv)-positive men who have sex with men (msm). there is a paucity of data published on the progression of high-grade ain to invasive cancer as well as on clinical and virological characteristics comparing anal margin and anal canal carcinoma. | 2010 | 20184584 |
| dna vaccines for cervical cancer. | human papillomavirus (hpv), particularly type 16, has been associated with more than 99% of cervical cancers. there are two hpv oncogenic proteins, e6 and e7, which play a major role in the induction and maintenance of cellular transformation. thus, immunotherapy targeting these proteins may be employed for the control of hpv-associated cervical lesions. although the commercially available preventive hpv vaccines are highly efficient in preventing new hpv infection, they do not have therapeutic ... | 2010 | 20182584 |
| human papillomavirus genotyping using archival vulval dysplastic or neoplastic biopsy tissues: comparison between the inno-lipa and linear array assays. | the roche linear array (la) and innogenetics inno-lipa human papillomavirus (hpv) genotyping assays were compared for paraffin-embedded vulval tissues. the la detected amplifiable dna in 28 (57%) out of 49 biopsy specimens, 20 (40%) being hpv genotyped, compared to 49 (100%) and 41 (83%), respectively, detected by the inno-lipa. the inno-lipa provides greater sensitivity for hpv genotyping in archival tissue. | 2010 | 20181920 |
| human papillomavirus, p16 and p53 expression associated with survival of head and neck cancer. | abstract: | 2010 | 20181227 |
| comment re: detection of cervical precancer by hpv genotype. | 2010 | 20179199 | |
| european guidelines for quality assurance in cervical cancer screening. second edition--summary document. | european guidelines for quality assurance in cervical cancer screening have been initiated in the europe against cancer programme. the first edition established the principles of organised population-based screening and stimulated numerous pilot projects. the second multidisciplinary edition was published in 2008 and comprises approximately 250 pages divided into seven chapters prepared by 48 authors and contributors. considerable attention has been devoted to organised, population-based program ... | 2010 | 20176693 |
| molecular targeted therapies in all histologies of head and neck cancers: an update. | this article reviewed the recent developments in molecular targeted therapy in head and neck cancers. a brief summary of other pathways of interest is also enclosed. | 2010 | 20173639 |
| is recurrent pseudoepitheliomatous keratotic balanitis related to human papillomavirus infection? | 2010 | 20169317 | |
| requiring human papillomavirus vaccine for immigrant women. | the centers for disease control and prevention advisory committee on immunization practices recommends human papillomavirus (hpv) vaccination of 11- to 12-year-old girls, with catch-up vaccination for girls and women aged 13 to 26 years. although compulsory hpv vaccination is not currently mandated for any u.s. population, immigrant women aged 11-26 years are now required to receive the first injection of the vaccine (the full series consists of three doses) as a result of the 1996 illegal immig ... | 2009 | 20168117 |
| sexually transmitted diseases and anorectum. | sexually transmitted diseases (std) are a major public health problem because their incidence is increasing worldwide despite prevention campaigns and because they raise the risk of hiv infection. anorectal localisations of std are common among men who have sex with men (msm) but can also be seen among heterosexuals (men or women). transmission of such infections is due to anal sex or to other sexual behaviours like "fisting". although some pathogens (like human papillomavirus-hpv) are common in ... | 2009 | 20163035 |
| quinacrine sterilization and gynecologic cancers: a case-control study in northern vietnam. | over 100,000 women worldwide have been sterilized by insertion of quinacrine into the uterus to induce tubal scarring. concern has been expressed about possible carcinogenicity, and specifically the risk of uterine cancer. | 2010 | 20160560 |
| dual action microbicides: reappraisal of their roles in contraceptive research. | of the variety of contraceptive options available for women, very few provide dual protection against sexually transmitted diseases. due to increased incidence of human immunodeficiency virus type 1 (hiv-1), genital herpes, hepatitis b and human papilloma virus, development of novel contraceptive strategies that incorporate antiviral activity has become the top priority in contraceptive research. topical microbicides are now considered to be the last ray of hope, as they would ideally provide pr ... | 2010 | 20158995 |
| the mrna decay factor tristetraprolin (ttp) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting e6-ap ubiquitin ligase. | the rna-binding protein tristetraprolin (ttp) regulates expression of many cancer-associated and proinflammatory factors through binding au-rich elements (are) in the 3'-untranslated region (3'utr) and facilitating rapid mrna decay. here we report on the ability of ttp to act in an anti-proliferative capacity in hpv18-positive hela cells by inducing senescence. hela cells maintain a dormant p53 pathway and elevated telomerase activity resulting from hpv-mediated transformation, whereas ttp expre ... | 2009 | 20157568 |
| longitudinal study of human papillomavirus persistence and cervical intraepithelial neoplasia grade 2/3: critical role of duration of infection. | the natural history of human papillomavirus (hpv) infections in older women is critical for preventive strategies, including vaccination and screening intervals, but is poorly understood. in a 7-year population-based cohort study in guanacaste, costa rica, we examined whether women's age and the duration of carcinogenic hpv infections influenced subsequent persistence of infection and risk of cervical intraepithelial neoplasia grade 2 (cin 2) or worse disease. | 2010 | 20157096 |
| [women's knowledge about cervical cancer]. | the human papillomavirus-infection is one of the most frequent sexually transmitted disease; it is detectable in nearly all cases of cervical cancer. nowadays, the incidence of cervical cancer is unacceptable high. | 2010 | 20154001 |
| vaccinating adolescent girls against human papillomavirus-who decides? | 2010 | 20153358 | |
| providing high quality information about human papillomavirus for women after treatment for high-grade cervical dysplasia. | the present study aimed to inform the production of a resource for women who have had a high-grade cervical abnormality and are scheduled to undergo testing for human papillomavirus (hpv) at their 12-month follow-up. | 2010 | 20152096 |
| cloning and characterization of cell strains derived from human corneal stroma and sclera. | to establish human corneal stroma- and sclera-derived cells as models for studying diseases of the anterior segment of the eye. | 2010 | 20151280 |
| combining t-cell vaccination and application of agonistic anti-gitr mab (dta-1) induces complete eradication of hpv oncogene expressing tumors in mice. | we generated an adenovirus-based t-cell vaccine (ad-p14) that reliably elicits t-cell responses to human papillomavirus (hpv) oncogenes of the 2 most common high-risk hpv serotypes. the artificial gene used to create the vaccine comprising 415 aa (1248 bp) was cloned by fusing 14 polymerase chain reaction fragments of hpv16 and hpv18 e6 and e7 oncogenes devoid of sequences with transforming potential. although ensuring maximal biologic safety, the construct includes approximately 70% of the rele ... | 2010 | 20145549 |
| human papillomavirus types 16, 18, and 31 serostatus and prostate cancer risk in the prostate cancer prevention trial. | since human papillomavirus (hpv) infection was first identified as a risk factor for cervical cancer, several seroepidemiologic and tissue-based studies have investigated hpv in relation to prostate cancer, another common genitourinary malignancy, with mixed results. to further inform this potential association, we conducted a large, prospective investigation of hpv types 16, 18, and 31 in relation to risk of prostate cancer in the prostate cancer prevention trial. cases were a sample of men dia ... | 2010 | 20142255 |
| invasive and in situ cervical cancer reported to the vaccine adverse event reporting system (vaers). | the quadrivalent human papillomavirus (hpv) vaccine was recommended in 2006 for routine vaccination of 11 or 12-year-old girls, with catchup through age 26 years, for the prevention of genital hpv-related diseases. the vaccine adverse event reporting system (vaers) is a national spontaneous surveillance system of adverse events following vaccination in the united states. the objective of this study was to identify and review vaers reports of invasive and in situ cervical cancer in women immunize ... | 2010 | 20141382 |
| presence of human papillomavirus (hpv) in vulvar squamous cell carcinoma (vscc) and sentinel node. | to investigate the presence of hpv in vscc and sentinel nodes (sn) in patients in sweden and the possible influence of hpv on prognosis. | 2010 | 20138657 |
| epidemiology and pathology of hpv disease in males. | it is currently recognized that besides the significant impact of human papillomavirus (hpv) infection in females, hpv causes substantial disease in men as well. genital warts are a common manifestation of male infection with hpv. genital warts are highly infectious and approximately 65% of people who have sex with an infected partner will develop warts themselves. more than 90% of genital warts are caused by non-oncogenic hpv types 6 and 11. in addition, recurrent respiratory papillomatosis is ... | 2010 | 20138345 |
| pem renders tumor cells resistant to apoptotic cell death induced by a cd8+ t cell-mediated immune response or anticancer drug treatment. | pem, a member of homeobox genes, is an oncofetal gene which is preferentially expressed in reproductive tissues and in multiple tumor cell lines. however, the function of pem in tumor cell lines has not been elucidated. herein we report that the ectopic expression of pem in tc-1, a human papillomavirus type 16 (hpv-16) e7-expressing surrogate cervical tumor cell line, demonstrated a significant increase in extracellular signal-regulated kinase (erk) activity and multiple resistance to various ap ... | 2010 | 20137854 |
| diagnostic efficacy of real-time optical coherence tomography in the management of preinvasive and invasive neoplasia of the uterine cervix. | determine the sensitivity and specificity of optical coherence tomography (oct) as an adjunct to colposcopy in the detection of cervical intraepithelial neoplasia (cin) grade 2 or higher in a real-time clinical evaluation. | 2010 | 20134271 |
| human papillomavirus dna in plasma of patients with hpv16 dna-positive uterine cervical cancer. | the squamous cell carcinoma antigen is considered the most accurate serologic tumor marker for uterine cervical carcinoma. however, serum squamous cell carcinoma antigen levels were found to correlate significantly with clinical severity of atopic dermatitis and chronic renal failure. the present study was conducted in patients with human papillomavirus 16 dna-positive uterine cervical cancer to determine the plasma level of human papillomavirus 16 dna and the diagnostic values of plasma human p ... | 2010 | 20133337 |
| prevalence and type distribution of human papillomavirus in women with cervical lesions in liaoning province, china. | instruction: type-specific persistence of human papillomavirus (hpv) infection can cause invasive cervical cancer. the distribution and prevalence of hpv genotypes depend on the geographic region and on demographic factors. | 2010 | 20130516 |
| interferon regulatory factor (irf)-2 activates the hpv-16 e6-e7 promoter in keratinocytes. | interferon regulatory factors (irfs) are critical mediators of gene expression, cell growth and immune responses. we previously demonstrated that interferon (ifn) induction of early viral transcription and replication in several mucosal hpvs requires irf-1 binding to a conserved interferon response element (ire). here we show that the irf-2 protein serves as a baseline transactivator of the hpv-16 major early promoter, p97. cotransfections in irf knockout cells confirmed that basal hpv-16 promot ... | 2010 | 20129639 |
| risk-adapted primary hpv cervical cancer screening project in wolfsburg, germany--experience over 3 years. | currently, the german cervical cancer screening program encompasses an annual cytological papanicolaou (pap) smear. however, primary screening for cervical cancer using human papillomavirus (hpv) dna testing detects cervical pre-cancerous lesions with a significantly higher sensitivity than the pap smear-based cytology. | 2009 | 20129072 |
| high genotyping concordance between the digene hpv genotyping rh test and the reverse line blot genotyping assay on gp5+/6+-pcr products. | based on epidemiologic studies, 18 mucosal human papillomavirus (hpv) types have been classified as (probably) high-risk (hr) (i.e., hpv 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, and 82). recognition of hr hpv at the individual type level may be valuable in clinical management of hr hpv-positive women. | 2009 | 20129069 |
| detection of 14 human papillomavirus genotypes in cervical samples in women from a central-southern area of italy showing different pap test results. | we evaluated the prevalence of human papillomavirus (hpv) infection and correlated the molecular test results with the cytological examination data (pap test) in 364 women living in central-southern italy (molise region), by means of polymerase chain reaction hpv dna genotyping and of cervical cytology. one hundred and twenty-eight women resulted hpv positive (35.2%), hpv16 being the most frequent genotype. hpv positive women were significantly younger than negative patients (35.9 +/- 8.4 years ... | 2009 | 20128441 |
| [exploring the issue of cervical cancer prevention and control in women living with hiv/aids]. | shared risk factors mean that women engaging in unprotected sex are at risk of contracting both the human immunodeficiency virus (hiv) and the human papillomavirus (hpv). as hiv suppresses bodily immune systems, an hiv-positive woman with hpv will likely see a faster progression of cancer cells around the cervix. therefore, it is important to prevent and control cervical cancer in hiv-positive women. findings from the literature on this topic include: 1) hiv-positive women face a relatively grea ... | 2010 | 20127625 |
| epigenetic repression of e-cadherin by human papillomavirus 16 e7 protein. | a common feature shared between several human cancer-associated viruses, such as epstein-barr virus, hepatitis b virus and hepatitis c virus, and human papillomavirus (hpv) is the ability to reduce the expression of cellular e-cadherin. since e-cadherin is used by langerhans cells to move through the stratified epithelium, its reduction may affect the efficiency by which the immune system responds to hpv infection and the length of persistent hpv infections. we observed that the e7 protein of th ... | 2010 | 20123756 |
| predictors of parents' willingness to vaccinate for human papillomavirus and physicians' intentions to recommend the vaccine. | the present study examined potential predictors of parents' willingness to vaccinate their children for human papillomavirus (hpv) and physicians' intentions to encourage parents to vaccinate their children, now that the u.s. food and drug administration (fda) has approved a highly effective vaccine. | 2010 | 20123174 |
| enhanced humoral and cellular immune responses after sublingual immunization against human papillomavirus 16 l1 protein with adjuvants. | needle-free nonparenteral vaccines offer a number of practical advantages, especially in developing countries. to address the effects of vaccine administration route, we tested mucosal and systemic immune responses against human papillomavirus 16 l1(hpv16l1) protein using intranasal, intravaginal, transdermal, sublingual (sl) and intramuscular routes. the sl route provided the most effective mucosal secretory iga (siga) and serum igg responses. after a 150 microg antigen dose via the sl route, s ... | 2010 | 20116467 |
| immunogenicity and safety of human papillomavirus-16/18 as04-adjuvanted cervical cancer vaccine coadministered with combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus vaccine to girls and young women. | many countries recommend human papillomavirus (hpv) vaccination in female adolescents at an age when other vaccines are routinely administered. this open, randomized, multicenter study (108464/nct00426361) evaluated coadministration of hpv-16/18 as04-adjuvanted vaccine with diphtheria-tetanus-acellular pertussis-inactivated poliovirus vaccine (dtpa-ipv). | 2010 | 20113920 |
| acceptability of human papillomavirus vaccine for males: a review of the literature. | the quadrivalent human papillomavirus virus vaccine was recently licensed for use in males in the united states. this study reviews available published literature on acceptability among parents, health care providers, and young males. among 23 published articles, half were conducted in the united states. the majority (87%) used quantitative survey methodology, and 13% used more explorative qualitative techniques. convenience samples were used in most cases (74%) and 26% relied on nationally repr ... | 2010 | 20113917 |
| [expression, purification and immunogenicity of human papillomavirus type 11 virus-like particles from escherichia coli]. | to produce human papillomavirus type 11 virus-like particles (hpv11 vlps) from escherichia coli and to investigate its immunogenicity and type cross neutralization nature. | 2009 | 20112683 |
| human papilloma virus and cervical preinvasive disease. | cervical cancer lesions represent a major threat to the health of the women worldwide. human papillomavirus (hpv) is responsible for 99.7% of cervical cancer cases, the infectious etiology giving the possibility of preventing cervical cancer by vaccination. the most aggressive hpv types are 16 and 18, which cause about 70% of cases of invasive cancer. the vaccination is recommended to the girls aged 11-12. the diagnosis and the treatment of cervical preinvasive disease allow the doctor to preven ... | 2009 | 20108750 |
| [construction and immunogenicity evaluation of chimerical dna vaccine of human papillomavirus type 11]. | to construct chimerical dna vaccine plasmid of human papillomavirus type 11 (hpv11) l1-e7, and to evaluate its immunogenicity. | 2009 | 20104772 |
| association of hiv infection with distribution and viral load of hpv types in kenya: a survey with 820 female sex workers. | human papillomavirus (hpv) and hiv are each responsible for a considerable burden of disease. interactions between these infections pose substantial public health challenges, especially where hiv prevalence is high and hpv vaccine coverage low. | 2010 | 20102630 |
| surgical treatment of epidermodysplasia verruciformis. | epidermodysplasia verruciformis (ev) is a genodermatosis, characterized by human papilloma virus infection, with polymorphic and disseminated lesions that develop malignant transformation in approximately half of patients. | 2010 | 20100263 |
| relationship of atypical glandular cell cytology, age, and human papillomavirus detection to cervical and endometrial cancer risks. | to quantify the age-specific and reproductive organ-specific cancer risk after an atypical glandular cell (agc) cytologic interpretation in large clinic-based sample in which routine high-risk human papillomavirus (hpv) testing is conducted. | 2010 | 20093895 |
| protein p 16ink4a expression in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of uterine cervix. | the association of human papilloma virus (hpv) infection and cervical intraepithelial neoplasia (cin) is well recognized. interaction of hpv oncogenic proteins with cellular regulatory proteins leads to up regulation of p16 ink4a , a cdk inhibitor, which is a biomarker for hpv infection. we investigated p16 expression in cin and invasive squamous cell carcinoma (scc) which has not been reported in the indian population previously. | 2010 | 20090213 |
| antibody detection against hpv16 e7 & gp96 fragments as biomarkers in cervical cancer patients. | cervical cancer is the second most frequent cancer among females worldwide, especially human papilloma viruses (hpv) types 16 and 18. in viral systems the identification of serological markers would facilitate the diagnosis of hpv infections and virus-related disease. the aim of the present investigation was to determine and search for serologic markers in cervical cancer patients associated with hpv. | 2009 | 20090101 |
| prevalence, distribution and correlates of endocervical human papillomavirus types in brazilian women. | we determined the prevalence, distribution and correlates of human papillomavirus (hpv) types in 386 mixed-income, sexually active women in são paulo, brazil. endocervical samples were tested for hpv dna with l1 primers my09 and my11; negative and indeterminate samples were retested using gp 5+/6+ consensus primers. hpv was detected in 35% of all women; high-risk/probable high-risk types in 20%; low-risk types in 7%; and an indeterminate type in 10%. twenty-five hpv types were found overall: 17 ... | 2010 | 20089995 |
| the risk of cin ii or greater in a one-year follow-up period in patients with asc-h interpreted with cytology. | to explore the risk of cin ii or greater in patients with cytologically interpreted atypical squamous cells, cannot exclude high grade squamous intraepithelial lesion (asc-h) in a one-year follow-up period. | 2010 | 20089347 |
| mechanisms of cell entry by human papillomaviruses: an overview. | as the primary etiological agents of cervical cancer, human papillomaviruses (hpvs) must deliver their genetic material into the nucleus of the target cell. the viral capsid has evolved to fulfil various roles that are critical to establish viral infection. the particle interacts with the cell surface via interaction of the major capsid protein, l1, with heparan sulfate proteoglycans. moreover, accumulating evidence suggests the involvement of a secondary receptor and a possible role for the min ... | 2010 | 20089191 |
| [the statement of polish gynecological society experts about human papillomavirus (hpv) vaccine use to prevent cervical cancer (state of the art from the 19th of september 2009)]. | 2009 | 20088404 | |
| inverted immature metaplasia of the uterine cervix. | 2010 | 20085521 | |
| the cost effectiveness of a quadrivalent human papillomavirus vaccine (6/11/16/18) in hungary. | a transmission dynamic model was used to assess the epidemiological and economic impact of a quadrivalent human papillomavirus (hpv) (6/11/16/18) vaccine in preventing cervical cancer, cervical intraepithelial neoplasia grades 2 and 3 (cin 2/3), cin 1 and genital warts in hungary. | 2010 | 20085477 |
| common genetic variants and risk for hpv persistence and progression to cervical cancer. | hpv infrequently persists and progresses to cervical cancer. we examined host genetic factors hypothesized to play a role in determining which subset of individuals infected with oncogenic human papillomavirus (hpv) have persistent infection and further develop cervical pre-cancer/cancer compared to the majority of infected individuals who will clear infection.we evaluated 7140 tag single nucleotide polymorphisms (snps) from 305 candidate genes hypothesized to be involved in dna repair, viral in ... | 2010 | 20084279 |
| p634a4 and tap73 immunocytochemistry in liquid-based cervical cytology--potential biomarkers for diagnosis and progress prediction of cervical neoplasia. | p63 and p73 are two homologues of the important tumor suppressor gene p53. in this study, we investigated p63 and p73 expression by immunocytochemistry using antibodies for tap73 and p634a4 isoforms in 91 high-grade and 107 low-grade squamous intraepithelial lesions, 212 atypical squamous cells of undetermined significance, 9 squamous cell carcinomas and 63 normal samples from an asian screening population together with 47 hospital samples of carcinomas. there was significant correlation between ... | 2010 | 20081800 |
| [vaccination in paediatric oncohaematology]. | one of the most important elements in prophylaxis of infectious diseases of children, is vaccination. it is essential that vaccination should be used correctly and safely in children in immunosupression, including the patients suffering from haematological malignancies. oncological diseases as well as anticancer therapy disturb the functioning of the immunological system. particulary deep immunosupression is observed in patients who have undergone stem cell transplantation. for this reason most ... | 2009 | 20081279 |
| prevalence and genotype identification of human papillomavirus in women undergoing voluntary cervical cancer screening in molise, central italy. | we examined the prevalence of hr- and lr-hpv by linear array genotyping test in 299 women aged 18-63 years who consecutively visited molise region main hospitals for routine pap smear between february and august 2008. ninety women were positive for any hpv (30.1%), and 66 for any hr-hpv (22.1%). the most prevalent hr-hpv types were hpv 16 (22.2% of all women with hpv infection), hpv 53 (14.4%), and hpv 66 (14.4%). hpv infections increased from 15.8% in the 18-20 years group to 50.0% in the 21-23 ... | 2010 | 20080070 |
| immunomodulatory activity of a plant extract containing human papillomavirus 16-e7 protein in human monocyte-derived dendritic cells. | this study reports the immunomodulatory activity on human monocyte derived dendritic cells (mddcs) of a vaccine preparation shown to be effective against an hpv16-related tumour in an animal model. the vaccine is composed of extract from nicotiana benthamiana leaves containing hpv16 e7 protein expressed by a potato virus x-derived vector (nbpvx-e7). the effect of the extract was evaluated on mddc differentiation and maturation by monitoring the phenotypic expression of specific markers. the resu ... | 2009 | 20074460 |
| the pdz domain binding motif (pbm) of human t-cell leukemia virus type 1 tax can be substituted by heterologous pbms from viral oncoproteins during t-cell transformation. | several tumor viruses, such as human t-cell leukemia virus (htlv), human papilloma virus (hpv), human adenovirus, have high-oncogenic and low-oncogenic subtypes, and such subtype-specific oncogenesis is associated with the pdz-domain binding motif (pbm) in their transforming proteins. htlv-1, the causative agent of adult t-cell leukemia, encodes tax1 with pbm as a transforming protein. the tax1 pbm was substituted with those from other oncoviruses, and the transforming activity was examined. tax ... | 2010 | 20069350 |
| re: cost-effectiveness analysis of human papillomavirus vaccination in the netherlands. | 2010 | 20068192 | |
| cost-effectiveness of human papillomavirus vaccination for prevention of cervical cancer in taiwan. | human papillomavirus (hpv) infection has been shown to be a major risk factor for cervical cancer. vaccines against hpv-16 and hpv-18 are highly effective in preventing type-specific hpv infections and related cervical lesions. there is, however, limited data available describing the health and economic impacts of hpv vaccination in taiwan. the objective of this study was to assess the cost-effectiveness of prophylactic hpv vaccination for the prevention of cervical cancer in taiwan. | 2010 | 20064239 |
| clinical and prognostic significance of human papillomavirus dna in the sperm or exfoliated cells of infertile patients and subjects with risk factors. | to evaluate human papillomavirus (hpv) sperm infection and its correlation with sperm parameters in infertile patients and subjects with risk factors. | 2010 | 20056213 |
| hpv prevalence in colombian women with cervical cancer: implications for vaccination in a developing country. | human papillomavirus (hpv) vaccines have been considered potentially cost-effective for the reduction of cervical cancer burden in developing countries; their effectiveness in a public health setting continues to be researched. we conducted an hpv prevalence survey among colombian women with invasive cancer. paraffin-embedded biopsies were obtained from one high-risk and one low-middle-risk regions. gp5+/gp6+ l1 primers, rlb assays, and e7 type specific pcr were used for hpv-dna detection. 217 c ... | 2009 | 20052389 |
| [summary of the practice guideline 'prevention and early diagnosis of cervical cancer' of the dutch college of general practitioners]. | a persistent infection with human papillomavirus (hpv) underlies all cases of cervical cancer. hpv testing is repeated 6 months after initial pap smears 2 or 3a1. as vaccination against hpv is now included in the national immunisation programme of the netherlands, yearly cervical cancer morbidity and mortality rates are expected to be cut by half. after vaccination against hpv, women still need to participate in the cervical cancer screening programme. breastfeeding is no longer a contraindicati ... | 2009 | 20051149 |
| cost-effectiveness analysis of cervical cancer prevention based on a rapid human papillomavirus screening test in a high-risk region of china. | this study assessed the cost-effectiveness of a new, rapid human papillomavirus (hpv)-dna screening test for cervical cancer prevention in the high-risk region of shanxi, china. using micro-costing methods, we estimated the resources needed to implement preventive strategies using cervical cytology or hpv-dna testing, including the hybrid capture 2 (hc2) test (qiagen corp., gaithersburg, md) and the rapid hpv-dna carehpv test (qiagen). data were used in a previously published model and empirical ... | 2010 | 20049838 |
| major clinical research advances in gynecologic cancer 2009. | in this review, we summarized nine major clinical advances in gynecology which occurred in 2009. for cervical cancer, the role of human papillomavirus (hpv) test as a screening test, the efficacy of hpv vaccine for middle-aged women, randomized controlled trial (rct) regarding concurrent chemoradiation using gemcitabine plus cisplatin, and the efficacy of pazopanib for metastatic or recurrent disease were chosen. for endometrial cancer, the necessity of systematic pelvic lymphadenectomy in early ... | 2009 | 20041096 |
| colposcopic characteristics of high-risk human papillomavirus-related cervical lesions. | because high-risk human papillomavirus (hrhpv) is the necessary factor in the development of high-grade cervical lesions, knowing the colposcopic differences between hrhpv-positive and hrhpv-negative lesions could be of value. we have evaluated whether there are colposcopic differences between lesions testing hrhpv-positive or hrhpv-negative. | 2010 | 20040836 |
| marketing and the hpv vaccine. | 2009 | 20040550 | |
| adverse events and quadrivalent human papillomavirus recombinant vaccine. | 2009 | 20040547 | |
| [perspective of cervical cancer prevention and control in developing countries and areas]. | cervical cancer ranks the second common cancer in women, affecting women severely in developing countries. it is a critical issue to develop simple, rapid, accurate, safe, acceptable, and inexpensive screening tests which can be used in cervical cancer prevention programs in developing countries. due to the shortage of funding and qualified cytological professionals in most developing countries, who has been actively promoting visual inspection with acetic acid/iodine solution (via/vili) as the ... | 2010 | 20038301 |
| the basaloid cell is the best tissue marker for human papillomavirus in invasive penile squamous cell carcinoma: a study of 202 cases from paraguay. | human papillomavirus (hpv) has been reported in 12-82% of penile squamous cell carcinomas (scc). there is an association of the virus with basaloid and warty carcinomas but the reported prevalence is variable. the causes of these variations are not clear. they may be owing to geographic differences, the use of different techniques to detect hpv, the status of the original paraffin blocks, or to variable criteria in tumor classification. the aims of the study were to determine the prevalence of h ... | 2010 | 20035150 |
| recombination of human papillomavirus-16 and host dna in exfoliated cervical cells: a pilot study of l1 gene methylation and chromosomal integration as biomarkers of carcinogenic progression. | human papillomavirus-16 dna replicates in productive infections in circular form, but is found in most carcinomas integrated into the host cell dna. because this transition is essential for carcinogenesis, detailed research is desirable and may help to triage patients with abnormal pap smears. previous studies addressed the chromosomal integration of hpv-16 dna in biopsies of tumors by an indirect biomarker, methylation of the viral l1 gene and by reverse ligation polymerase chain reaction (rlip ... | 2010 | 20029805 |
| ccl2 blockade augments cancer immunotherapy. | altering the immunosuppressive microenvironment that exists within a tumor will likely be necessary for cancer vaccines to trigger an effective antitumor response. monocyte chemoattractant proteins (such as ccl2) are produced by many tumors and have both direct and indirect immunoinhibitory effects. we hypothesized that ccl2 blockade would reduce immunosuppression and augment vaccine immunotherapy. anti-murine ccl2/ccl12 monoclonal antibodies were administered in three immunotherapy models: one ... | 2010 | 20028856 |
| the cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation. | histone deacetylases (hdacs) are chromatin-modifying enzymes that are involved in the regulation of proliferation, differentiation and development. hdac inhibitors induce cell cycle arrest, differentiation, or apoptosis in tumor cells and are therefore promising antitumor agents. numerous genes were found to be deregulated upon hdac inhibitor treatment; however, the relevant target enzymes are still unidentified. hdac1 is required for mouse development and unrestricted proliferation of embryonic ... | 2010 | 20028735 |
| communication challenges of hpv vaccination. | the uk has introduced a national human papillomavirus (hpv) immunisation programme for girls aged 12-13 from autumn 2008. previous research has explored public understanding of the causes of cervical cancer and found little awareness of the role of hpv. | 2010 | 20022908 |
| prophylactic hpv vaccines: the finnish perspective. | finland is a country with a dual role in the human papillomavirus (hpv) field. finnish scientists have pioneered in hpv research and participated in international hpv vaccine trials, but officially finland is reluctant to implement hpv vaccines into its national vaccination program owing to the reasons discussed in this article. in contrast to other european countries, finnish authorities were reluctant to initiate the evaluation process for hpv vaccines after licensure. instead of prompt implem ... | 2010 | 20021305 |
| association of polymorphism in fcgr3a gene and progression of low-grade precursor lesions of cervical carcinoma. | polymorphisms in receptors of the constant part of antibodies (fcr) have been associated with susceptibility to disease and viral infections but have not been studied in cervical carcinogenesis. the distribution of the polymorphism v158f (rs396991) in fcgr3a in cervical smears was detected in a group of 84 women with stable or regressed low-grade squamous intraepithelial lesions (group i) and a group of 54 women with high-grade squamous intraepithelial lesions (hsil) (group ii). human papillomav ... | 2010 | 20018222 |
| malignant transformation of a highly aggressive human papillomavirus type 11-associated recurrent respiratory papillomatosis. | the objective is to present an uncommon case of squamous cell carcinoma (scc) arising from extensive recurrent respiratory papillomatosis (rrp) involving the upper and lower airway and temporal bone. | 2010 | 20015762 |
| atypical glandular cells (agc): thinprep imaging system (tis), manual screening (ms), and correlation with hybrid capture 2 (hc2) hpv dna testing. | the aim of the study was to determine if the thinprep imaging system (t1s) improves the positive predictive value (ppv) of atypical glandular cell (agc) diagnosis for identifying hpv-related squamous and/or glandular lesions over manual screening (ms), and if human papilloma virus (hpv)-dna testing improves the diagnostic yield. | 2010 | 20014311 |
| the precancerous effect of emitted cooking oil fumes on precursor lesions of cervical cancer. | although cooking emission from high-temperature frying has been deemed a group 2a carcinogen by the international agency for research on cancer, little is known about its impact on cervical tumorigenesis. to investigate the precancerous consequence of cooking oil fumes on cervical intraepithelial neoplasm (cin), a community-based case-control study, which takes all known risk factors into consideration, was conducted in taiwan. from 2003 to 2008, in a pap smear screening and biopsy examination n ... | 2010 | 20013811 |