Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| hyperbolic relation between beta-cell function and insulin sensitivity for type 2 diabetes mellitus, malaria, influenza, helicobacter pylori, chlamydia pneumoniae, and hepatitis c virus infection-induced inflammation/oxidative stress and temporary insulin resistance in central africans | background/aim: we calculated the homeostatic model assessment (homa) for estimating insulin sensitivity and beta-cell function in normal, healthy nondiabetics with infections (malaria, influenza, hiv, helicobacter pylori, chlamydia pneumoniae, and hepatitis c virus), type 2 diabetic black patients, and healthy controls from kinshasa, dr congo. materials and methods: a case-control study was carried out between 2006 and 2007 for black central african participants managed for homa.results: in tot ... | 2017 | 29306246 |
| development of a multiplex taqman real-time pcr assay for the detection of chlamydia psittaci and chlamydia pneumoniae in human clinical specimens. | diagnosis of chlamydia psittaci and chlamydia pneumoniae infections has traditionally relied on serological assays. we developed a multiplex real-time pcr assay for detection of c. psittaci, c. pneumoniae and an internal control. results of this assay demonstrated 100% concordance compared to results of previously tested human clinical specimens. | 2017 | 29291900 |
| growth of chlamydia pneumoniae is enhanced in cells with impaired mitochondrial function. | effective growth and replication of obligate intracellular pathogens depend on host cell metabolism. how this is connected to host cell mitochondrial function has not been studied so far. recent studies suggest that growth of intracellular bacteria such as chlamydia pneumoniae is enhanced in a low oxygen environment, arguing for a particular mechanistic role of the mitochondrial respiration in controlling intracellular progeny. metabolic changes in c. pneumoniae infected epithelial cells were an ... | 2017 | 29259924 |
| multicenter evaluation of the eplex® respiratory pathogen panel for the detection of viral and bacterial respiratory tract pathogens in nasopharyngeal swabs. | background: the performance of the new eplex® respiratory pathogen (rp) panel (genmark diagnostics) for the simultaneous detection of 19 viruses (influenza a, influenza a h1, influenza a 2009 h1, influenza a h3, influenza b, adenovirus, coronaviruses [hku1, oc43, nl63, 229e], human rhinovirus/enterovirus, human metapneumovirus, parainfluenza viruses 1, 2, 3 and 4, respiratory syncytial virus (rsv) [rsva and rsv b]) and two bacteria (mycoplasma pneumoniae and chlamydia pneumoniae) was evaluated.m ... | 2017 | 29212701 |
| molecular etiological profile of atypical bacterial pathogens, viruses and coinfections among infants and children with community acquired pneumonia admitted to a national hospital in lima, peru. | the main objective of this study was to detect the presence of 14 respiratory viruses and atypical bacteria (mycoplasma pneumoniae, chlamydia pneumoniae), via polymerase chain reaction in patients under 18 years old hospitalized due to community-acquired pneumonia (cap) from lima, peru. | 2017 | 29208015 |
| frequency of detection of chlamydophila pneumoniae using bronchoalveolar lavage fluid in patients with community-onset pneumonia. | chlamydophila pneumoniae is a causative pathogen of lower respiratory tract infection, which generally infects healthy, young people. however, it is often difficult to evaluate acute c. pneumoniae infection using upper respiratory tract specimens and/or sputum samples due to its persistent infection or colonization. the interpretation of frequency of detection of c. pneumoniae seems to be insufficient in community-onset pneumonia. the aim of this study was to evaluate the presence of c. pneumoni ... | 2017 | 29153416 |
| impact of capsaicin, an active component of chili pepper, on pathogenic chlamydial growth (chlamydia trachomatis and chlamydia pneumoniae) in immortal human epithelial hela cells. | chlamydia trachomatis is the leading cause of sexually transmitted infections worldwide. capsaicin, a component of chili pepper, which can stimulate actin remodeling via capsaicin receptor trpv1 (transient receptor potential vanilloid 1) and anti-inflammatory effects via pparγ (peroxisome proliferator-activated receptor-γ) and lxrα (liver x receptor α), is a potential candidate to control chlamydial growth in host cells. we examined whether capsaicin could inhibit c. trachomatis growth in immort ... | 2018 | 29132924 |
| chlamydia pneumoniae exploits adipocyte lipid chaperone fabp4 to facilitate fat mobilization and intracellular growth in murine adipocytes. | fatty acid-binding protein 4 (fabp4), a cytosolic lipid chaperone predominantly expressed in adipocytes and macrophages, modulates lipid fluxes, trafficking, signaling, and metabolism. recent studies have demonstrated that fabp4 regulates metabolic and inflammatory pathways, and in mouse models its inhibition can improve type 2 diabetes mellitus and atherosclerosis. however, the role of fabp4 in bacterial infection, metabolic crosstalk between host and pathogen, and bacterial pathogenesis have n ... | 2018 | 29108997 |
| dapsone treatment is efficient against persistent cutaneous and gastrointestinal symptoms in children with henoch-schönlein purpura. | henoch-schönlein purpura (hsp) is a systemic disorder characterized by leukocytoclastic vasculitis involving the capillaries and by the deposition of iga immune complexes. an association between hsp and atypical bacteria is uncommon in children. | 2017 | 29097818 |
| the association between serological features of chronic chlamydia pneumoniae infection and markers of systemic inflammation and nutrition in copd patients. | chlamydia pneumoniae is an obligatory human pathogen involved in lower and upper airway infections, including pneumonia, bronchitis. asymptomatic c. pneumoniae carriage is also relatively common. the association of c. pneumoniae infections with the chronic obstructive pulmonary disease (copd) course is unclear. | 2017 | 29069917 |
| serological analysis and drug resistance of chlamydia pneumoniae and mycoplasma pneumoniae in 4500 healthy subjects in shenzhen, china. | to understand the prevalence and distribution of chlamydia pneumoniae (cp) and mycoplasma pneumoniae (mp) in the population and to provide a basis for the prevention and treatment of respiratory tract infection. | 2017 | 29057257 |
| identification of privileged antichlamydial natural products by a ligand-based strategy. | the obligate intracellular pathogen chlamydia pneumoniae remains a difficult target for antimicrobial therapy. owing to the permeability barrier placed by bacterial and host vacuolar membranes, as well as the propensity of the bacterium for persistent infections, treatment failures are common. despite the urgent need for new antichlamydial compounds, their discovery is challenged by the technically demanding assay procedures and lack of validated targets. an alternative strategy of using natural ... | 2017 | 29043803 |
| presence of atopy increases the risk of asthma relapse. | to describe the point prevalence of respiratory viruses/atypical bacteria using pcr and evaluate the impact of respiratory viruses/atypical bacteria and atopy on acute severity and clinical recovery in children with hospitalised and non-hospitalised asthma exacerbations. | 2017 | 29021189 |
| infections and chlamydia pneumoniae antibodies influence the functional outcome in thrombolysed strokes. | thrombolysis is effective in ischemic stroke patients, but some factors influence its benefit. previous infections could increase the risk of ischemic stroke by an activation of systemic inflammation. we analysed the influence of previous infections and chlamydia pneumoniae serology on functional outcome in thrombolysed stroke patients. | 2017 | 28991723 |
| chlamydia pneumoniae inclusion membrane protein cpn0147 interacts with host protein creb3. | chlamydiae are gram-negative obligate intracellular bacteria that cause diseases with significant medical and economic impacts. like other chlamydial species, chlamydia pneumoniae possesses a unique developmental cycle, the infectious elementary body gains access to the susceptible host cell, where it transforms into the replicative reticulate body. the cytoplasmic vacuole where chlamydia pneumoniae replicates is called an inclusion, which is extensively modified by the insertion of chlamydial e ... | 2017 | 28957394 |
| the etiology of community-acquired pneumonia among children under 5 years of age in mainland china, 2001-2015: a systematic review. | the aim of this systematic review was to examine the etiology of community-acquired pneumonia (cap) among chinese children younger than 5 years and provide evidence for further cost-effectiveness analyses for vaccine development, diagnostic strategies and empirical treatments. | 2017 | 28922613 |
| interactions of antisera to different chlamydia and chlamydophila species with the ribosomal protein rps27a correlate with impaired protein synthesis in a human choroid plexus papilloma cell line. | chlamydia trachomatis (ct) and the chlamydophila species (cs) chlamydophila pneumoniae (cpn), and chlamydophila psittaci (cps) are suggested to induce autoantibodies causative of several human autoimmune disorders like rheumatoid arthritis and systemic lupus erythematosus (sle). the aim of the present study was therefore to identify cellular protein interaction partners with antisera to ct (α-ct) or cs (α-cs) and to identify functional consequences of such interaction in vitro. as detected with ... | 2017 | 28913776 |
| detection of specific chlamydia pneumoniae and cytomegalovirus antigens in human carotid atherosclerotic plaque in a chinese population. | to explore the relationship between certain pathogens, such as chlamydia pneumonia (cpn) and cytomegalovirus (cmv), and carotid atherosclerosis (as) in a chinese population.twenty-five carotid atherosclerotic stenosis patients from the beijing tiantan hospital (affiliated with capital medical university) participated in the study. after undergoing digital subtraction angiography (dsa) and/or computed tomography angiography (cta), the degree of carotid artery stenosis was over 70% in all cases, a ... | 2017 | 28903431 |
| atypical bacterial etiology of acute respiratory infections and clinical characterizations among iranian children. | acute respiratory infections (aris) in children younger than 5 years of age are one of the leading causes of morbidity and mortality, particularly in developing countries. mycoplasma pneumoniae and chlamydophila pneumoniae are prevalent causative agents of aris, worldwide. we sought m. pneumoniae and c. pneumoniae in respiratory samples from iranian children with aris. from november 2014 to april 2015, respiratory samples of 150 children aged 1 month to 15 years old were screened for presence o ... | 2017 | 28886324 |
| the impact of pathogen burden on leukocyte telomere length in the multi-ethnic study of atherosclerosis. | several infections have been linked to telomere shortening and in some cases these associations have varied by sex. we assessed the association between seropositivity to four persistent pathogens (cytomegalovirus (cmv), herpes simplex virus-1, helicobacter pylori, chlamydia pneumoniae), and total pathogen burden on leukocyte telomere length in a diverse us sample. data came from the multi-ethnic study of atherosclerosis, a population-based cohort study. we utilized cross-sectional survey data, a ... | 2017 | 28879822 |
| investigation of chlamydia pneumoniae infection in moroccan patients suffering from cardiovascular diseases. | chlamydia pneumoniae is an intracellular bacterium responsible for respiratory diseases and is highly involved in cardiovascular disease development, mainly atherosclerosis. the main objective of our study was to evaluate c. pneumoniae prevalence in moroccan patients suffering from cardiovascular diseases. a total of 115 patients with cardiovascular diseases were enrolled, and their clinical and behavioral information was recorded. blood was sampled from all patients as well as the atheroma plaq ... | 2017 | 28869155 |
| antimicrobial activity of bitespiramycin, a new genetically engineered macrolide. | the antimicrobial activity of bitespiramycin (bt) against chlamydia trachomatis (ct), chlamydia pneumoniae (cp), ureaplasma urealyticum (uu), and mycoplasma pneumoniae (mp), was compared with those of azithromycin (azm) and acetylspiramycin (at-sp) in vitro. furthermore, the anti-mp activities of bt and azm were evaluated in a hamster model. the activities of bt in vitro were similar to those of azm but were more effective than those of at-sp. bt effectively inhibited mp infection at a dose of 2 ... | 2017 | 28867456 |
| atypical bacterial pneumonia in the hiv-infected population. | human immunodeficiency virus (hiv)-infected individuals are more susceptible to respiratory tract infections by other infectious agents (viruses, bacteria, parasites, and fungi) as their disease progresses to acquired immunodeficiency syndrome. despite effective antiretroviral therapy, bacterial pneumonia (the most frequently occurring hiv-associated pulmonary illness) remains a common cause of morbidity and mortality in the hiv-infected population. over the last few decades, studies have looked ... | 2017 | 28856082 |
| acquisition of rab11 and rab11-fip2-a novel strategy for chlamydia pneumoniae early survival. | the initial steps in chlamydial infection involve adhesion and internalization into host cells and, most importantly, modification of the nascent inclusion to establish the intracellular niche. here, we show that chlamydia pneumoniae enters host cells via egfr-dependent endocytosis into an early endosome with a phosphatidylinositol 3-phosphate (pi3p) membrane identity. immediately after entry, the early chlamydial inclusion acquires early endosomal rab gtpases including rab4, rab5, rab7, as well ... | 2017 | 28787457 |
| [large vessel vasculitis : pathogenesis, diagnostic and medical management]. | large vessels vasculitis includes two diseases : 1) giant cell arteritis, formerly known as horton's arteritis and 2) takayasu arteritis. in this article, we will describe and compare the epidemiology, pathogenesis, diagnostic criteria and medical management of both vasculitis. t helper (th) 1 and th17 responses, genetic links and the role of viral (varicella zoster) and bacterial infection (mycoplasma pneumoniae or chlamydia pneumoniae) will be discussed. classification criteria, inflammation b ... | 2017 | 28722366 |
| hypothetical protein cpn0423 triggers nod2 activation and contributes to chlamydia pneumoniae-mediated inflammation. | chlamydia pneumoniae (c. pneumoniae) is pathogenic to humans, by causing pulmonary inflammation or bronchitis in both adolescents and young adults. however, the molecular signals linking c. pneumoniae components to inflammation remain elusive. this study was to investigate the effect of chlamydia-specific cpn0423 of c. pneumoniae on c. pneumoniae-mediated inflammation. | 2017 | 28693414 |
| iron homeostasis in tissues is affected during persistent chlamydia pneumoniae infection in mice. | chlamydia pneumoniae (c. pneumoniae) may be a mediator in the pathogenesis of atherosclerosis. for its growth c. pneumoniae depends on iron (fe), but how fe changes in tissues during persistent infection or affects bacterial replication in tissues is unknown. c. pneumoniae-infected c57bl/6j mice were sacrificed on days 4, 8, 20, and 40. mice had bacteria in the lungs and liver on all days. inflammatory markers, chemokine cxcl2 and interferon-gamma, were not affected in the liver on day 40. the c ... | 2017 | 28691023 |
| robust immunoreactivity of teenager sera against peptide 19 from porphyromonas gingivalis hsp60. | epitope spreading is a phenomenon in which distinct subdominant epitopes become major targets of the immune response. heat shock protein (hsp) 60 from porphyromonas gingivalis (pghsp60) and peptide 19 from pghsp60 (pep19) are immunodominant epitopes in autoimmune disease patients, including those with periodontitis. it remains unclear whether pep19 is a dominant epitope in subjects without periodontitis or autoimmune disease. the purpose of this study was to determine the epitope spreading patte ... | 2017 | 28680713 |
| high prevalence of chlamydophila pneumoniae infection in patients with myeloperoxidase antineutrophil cytoplasmic autoantibody (mpo-anca)-associated glomerulonephritis. | 2008 | 28656992 | |
| elevated sodium leads to the increased expression of hsp60 and induces apoptosis in huvecs. | atherosclerosis is the leading cause of death in the world. we have previously shown that expression of heat shock protein 60 (hsp60) on the surface of endothelial cells is the main cause of initiating the disease as it acts as a t cell auto-antigen and can be triggered by classical atherosclerosis risk factors, such as infection (e.g. chlamydia pneumoniae), chemical stress (smoking, oxygen radicals, drugs), physical insult (heat, shear blood flow) and inflammation (inflammatory cytokines, lipop ... | 2017 | 28604836 |
| methods for real-time pcr-based diagnosis of chlamydia pneumoniae, chlamydia psittaci, and chlamydia abortus infections in an opened molecular diagnostic platform. | the advances in molecular biology of the last decades have dramatically improved the field of diagnostic bacteriology. in particular, pcr-based technologies have impacted the diagnosis of infections caused by obligate intracellular bacteria such as pathogens from the chlamydiacae family. here, we describe a real-time pcr-based method using the taqman technology for the diagnosis of chlamydia pneumoniae, chlamydia psittaci, and chlamydia abortus infection. the method presented here can be applied ... | 2017 | 28600769 |
| macrolide therapy for community-acquired pneumonia due to atypical pathogens: outcome assessment at an early time point. | therapy directed against atypical pathogens in patients with community-acquired pneumonia (cap) is often recommended. this post-hoc analysis evaluated the effect of addition of a macrolide to ceftaroline fosamil or ceftriaxone treatment in atypical cap. | 2017 | 28599867 |
| a prolonged antibiotic protocol to treat persistent chlamydophila pneumoniae infection improves the extracranial venous circulation in multiple sclerosis. | objective chronic cerebrospinal venous insufficiency (ccsvi) is a condition associated with multiple sclerosis (ms). one mechanism that has been proposed is that the venous obstructions found in ms are due to a chronic persistent venulitis caused by the intra-cellular bacterial parasite, chlamydophila pneumoniae (cpn). the objective of the current study is to determine the effect of a combined antibiotic protocol (cap) on the venous flow in ms patients as measured by a quantitative duplex ultras ... | 2017 | 28583026 |
| mucositis secondary to chlamydia pneumoniae infection: expanding the mycoplasma pneumoniae-induced rash and mucositis concept. | the term mycoplasma pneumoniae-induced rash and mucositis (mirm) was recently proposed to identify the mucocutaneous condition secondary to m. pneumoniae infection that had historically been regarded among the more confusing pathologies of erythema multiforme and stevens-johnson syndrome. based on a number of previous reports, these syndromes require differentiation since they have different prognoses and specific treatment requirements. we report a case of oral and genital erosions that strongl ... | 2017 | 28568680 |
| severe acute asthma caused by chlamydophila pneumoniae infection. | asthma exacerbation is associated with respiratory infections, including those by viruses and atypical bacteria. we herein report a case of severe acute asthma in an adult caused by chlamydophila pneumoniae (c. pneumoniae) infection. a 39-year-old woman without a history of asthma reported to the emergency department with progressive worsening of cough, shortness of breath, and wheezing with low oxygen saturation. a computed tomography (ct) scan revealed patchy ground-glass opacity and bronchial ... | 2017 | 28560041 |
| infection-mediated asthma: etiology, mechanisms and treatment options, with focus on chlamydia pneumoniae and macrolides. | asthma is a chronic respiratory disease characterized by reversible airway obstruction and airway hyperresponsiveness to non-specific bronchoconstriction agonists as the primary underlying pathophysiology. the worldwide incidence of asthma has increased dramatically in the last 40 years. according to world health organization (who) estimates, over 300 million children and adults worldwide currently suffer from this incurable disease and 255,000 die from the disease each year. it is now well acce ... | 2017 | 28526018 |
| [bronchopulmonary infections caused by atypical pathogens in children : myth or reality?] | mycoplasma pneumoniae and chlamydia pneumoniae are the most common atypical pathogens seen in respiratory infections in children. currently, the management of atypical pneumonia due to these pathogens is blurry. the clinical features are hardly specific ; it appears that m. pneumoniae respiratory infect ions are associated with chest pain and the absence of wheezing, however, further confirmations are needed. hoarseness is frequently seen with c. pneumoniae infection. co-infections with viruses, ... | 2016 | 28525234 |
| chlamydia pneumoniae induces interferon gamma responses in peripheral blood mononuclear cells in children with allergic asthma. | respiratory infections caused by chlamydia pneumoniae have been associated with exacerbations of asthma. cell-mediated immunity (cmi) is critical for maintaining immunity. we compared interferon (ifn)-γ responses in c. pneumoniae-infected peripheral blood mononuclear cells (pbmc) in paediatric patients ± asthma. presence of c. pneumoniae was tested from asthma patients (n = 17) and non-asthmatic controls (n = 16) (pcr). pbmc were infected for 1 h ± c. pneumoniae ar-39 (moi = 0.1) and cultured fo ... | 2017 | 28480606 |
| influence of antibiotics on the detection of bacteria by culture-based and culture-independent diagnostic tests in patients hospitalized with community-acquired pneumonia. | specimens collected after antibiotic exposure may reduce culture-based bacterial detections. the impact on culture-independent diagnostic tests is unclear. we assessed the effect of antibiotic exposure on both of these test results among patients hospitalized with community-acquired pneumonia (cap). | 2017 | 28480285 |
| evolution of acute infection with atypical bacteria in a prospective cohort of children with community-acquired pneumonia receiving amoxicillin. | atypical bacteria are treatable causative agents of community-acquired pneumonia (cap). however, there is no conclusive evidence that a child with cap should receive empirical treatment against such agents. | 2017 | 28475737 |
| in situ detection of chlamydia pneumoniae, c. trachomatis, and cytokines among cardiovascular diseased patients from the amazon region of brazil. | chronic coronary artery disease has been associated, as a consequence of the local inflammatory reaction with previous or persistent infection with chlamydia pneumoniae, which led to the investigation of the association of cardiovascular disease and previous infection with c. trachomatis and the role of cytokine profile (in situ) markers in the vascular system tissues. | 2017 | 28435302 |
| infectious agents is a risk factor for myxomatous mitral valve degeneration: a case control study. | the etiology of myxomatous mitral valve degeneration (mvd) is not fully understood and may depend on time or environmental factors for which the interaction of infectious agents has not been documented. the purpose of the study is to analyze the effect of mycoplasma pneumoniae (mp), chlamydophila pneumoniae (cp) and borrelia burgdorferi (bb) on myxomatous mitral valve degeneration pathogenesis and establish whether increased in inflammation and collagen degradation in myxomatous mitral valve deg ... | 2017 | 28431520 |
| comparative study of the effects of acepromazine and structurally related compounds on the tnf-a release by monocytes stimulated by chlamydia pneumoniae. | 2003 | 28404432 | |
| acepromazine modulates cell differentiation: in vitro experiments on monocytes stimulated by chlamydia pneumoniae toxins. | 2001 | 28404253 | |
| sphingolipids are dual specific drug targets for the management of pulmonary infections: perspective. | sphingolipids are the major constituent of the mucus secreted by the cells of epithelial linings of lungs where they maintain the barrier functions and prevent microbial invasion. sphingolipids are interconvertible, and their primary and secondary metabolites have both structural and functional roles. out of several sphingolipid metabolites, sphingosine-1 phosphate (s1p) and ceramide are central molecules and decisive for sphingolipid signaling. these are produced by enzymatic activity of sphing ... | 2017 | 28400772 |
| [importance of respiratory virus in immunocompetent adult patients hospitalized with community-acquired pneumonia]. | community-acquired pneumonia (cap) is a relevant worldwide cause of morbidity and mortality in adult population, however its etiology is often not identified and therapy is empirical. | 2016 | 28393985 |
| molecular characterization of chlamydia pneumoniae associated to atherosclerosis. | chlamydia pneumoniae is a respiratory pathogen associated with chronic inflammatory diseases such as asthma and atherosclerosis, and its detection in human carotid and coronary atheroma suggests some support for its involvement in atherogenesis. the main objective of our study was to evaluate the association between chlamydia pneumoniae and atherosclerosis in moroccan patients through a case/control approach and detected strain genotyping. a total of 137 cases and 124 controls were enrolled, nes ... | 2017 | 28387800 |
| chlamydia pneumoniae infection promotes vascular endothelial cell angiogenesis through an iqgap1-related signaling pathway. | chlamydia pneumoniae (c. pneumoniae) infection plays a potential role in angiogenesis. however, it is still an enigma how c. pneumoniae is involved in this process. therefore, we investigated the effect of c. pneumoniae infection on angiogenesis, and then explored the roles of iqgap1-related signaling in c. pneumoniae infection-induced angiogenesis. c. pneumoniae infection significantly enhanced angiogenesis as assessed by the tube formation assay possibly by inducing vascular endothelial cell ( ... | 2017 | 28377051 |
| prevalence of atypical pathogens in patients with cough and community-acquired pneumonia: a meta-analysis. | community-acquired pneumonia (cap), acute cough, bronchitis, and lower respiratory tract infections (lrti) are often caused by infections with viruses or streptococcus pneumoniae. the prevalence of atypical pathogens mycoplasma pneumoniae, chlamydophila pneumoniae, legionella pneumophila, and bordetella pertussis among patients with these illnesses in the ambulatory setting has not been previously summarized. we set out to derive prevalence information from the existing literature. | 2016 | 28376442 |
| isolation of antimicrobial resistant bacteria in upper respiratory tract infections of patients. | haemophilus influenzae, streptococcus pyogenes, moraxella catarrhalis, staphylococcus aureus, and streptococcus pneumoniae are usual cause of upper respiratory tract infection cases. the present study aims the isolation of bacterial strains which are resistant to the commonly prescribed antibiotics. in total, 900 throat swabs were obtained from the patients suffering from upper respiratory tract infections residing in three different localities. the maximum number of isolates (64 %) were obtaine ... | 2016 | 28330238 |
| the relationship of chlamydophila pneumoniae with schizophrenia: the role of brain-derived neurotrophic factor (bdnf) and neurotrophin-3 (nt-3) in this relationship. | several pathogens have been suspected of playing a role in the pathogenesis of schizophrenia. chronic inflammation has been proposed to occur as a result of persistent infection caused by chlamydophila pneumoniae cells that reside in brain endothelial cells for many years. it was recently hypothesized that brain-derived neurotrophic factor (bdnf) and neurotrophin-3 (nt-3) may play prominent roles in the development of schizophrenia. nt-3 and bdnf levels have been suggested to change in response ... | 2017 | 28256360 |
| fluorocycline tp-271 is potent against complicated community-acquired bacterial pneumonia pathogens. | tp-271 is a novel, fully synthetic fluorocycline antibiotic in clinical development for the treatment of respiratory infections caused by susceptible and multidrug-resistant pathogens. tp-271 was active in mic assays against key community respiratory gram-positive and gram-negative pathogens, including streptococcus pneumoniae (mic90 = 0.03 µg/ml), methicillin-sensitive staphylococcus aureus (mssa; mic90 = 0.25 µg/ml), methicillin-resistant s. aureus (mrsa; mic90 = 0.12 µg/ml), streptococcus pyo ... | 2017 | 28251179 |
| contribution of common infections to cardiovascular risk in hiv positive individuals. | hiv-positive individuals are at increased risk for cardiovascular disease due to complex interactions between the increased incidence of traditional cardiovascular risk factors and hiv and antiretroviral-associated inflammation and dyslipidemia. increasing evidence suggests that a number of important co-pathogens, including cytomegalovirus, hepatitis c virus, and periodontal disease, are likely to also be contributing. mechanisms such as molecular mimicry and modification of lipids play a role; ... | 2017 | 28182619 |
| cholesterol uptake in the mouse aorta increases during chlamydia pneumoniae infection. | 2017 | 28158541 | |
| procalcitonin accurately identifies hospitalized children with low risk of bacterial community-acquired pneumonia. | lower procalcitonin (pct) concentrations are associated with reduced risk of bacterial community-acquired pneumonia (cap) in adults, but data in children are limited. | 2017 | 28158460 |
| the role of nod-like receptors in pulmonary infection. | pneumonia is caused by both viral and bacterial pathogens and is responsible for a significant health burden in the unites states. the innate immune system is the human body's first line of defense against these pathogens. the recognition of invading pathogens via pattern recognition receptors (prrs) leads to proinflammatory cytokine and chemokine production followed by recruitment and activation of effector immune cells. the nonspecific inflammatory nature of the innate immune response can resu ... | 2017 | 28157451 |
| high prevalence of mycoplasma pneumoniae and chlamydia pneumoniae in children with acute respiratory infections from lima, peru. | mycoplasma pneumoniae and chlamydia pneumoniae are atypical pathogens responsible for pneumonia and a leading cause of morbidity and mortality in low income countries. the study objective is to determine the prevalence of this pathogens in peruvian children with acute respiratory infections. | 2017 | 28129377 |
| prospective etiological investigation of community-acquired pulmonary infections in hospitalized people living with hiv. | the study of the etiological agents of community-acquired pulmonary infections is important to guide empirical therapy, requires constant updating, and has a substantial impact on the prognosis of patients. the objective of this study is to determine prospectively the etiology of community-acquired pulmonary infections in hospitalized adults living with hiv. patients were submitted to an extended microbiological investigation that included molecular methods. the microbiological findings were eva ... | 2017 | 28121925 |
| the association of chlamydia pneumonia and helicobacter pylori igg seropositivity with omentin-1, visfatin and adiponectin levels in postmenopausal women. | some adipocytokines are cardioprotective or pro-inflammatory for cardiovascular system. chronic infection with chlamydia pneumoniae and helicobacter pylori has been also considered as novel risk factors for atherosclerosis. the main aim of the current population-based study is to investigate the potential link between circulating adipocytokines and chlamydia pneumoniae or helicobacter pylori igg seropositivities. a total of 250 healthy postmenopausal women who participated in a prospective cohor ... | 2016 | 28120588 |
| neonatal apnea with chlamydia pneumoniae infection. | 2017 | 28102626 | |
| prevalence of chlamydophila pneumoniae and mycoplasma pneumoniae igm and igg antibodies in tunisian patients presenting with exacerbation of chronic obstructive pulmonary disease. | we aimed to assess the prevalence of chlamydophila pneumoniae and mycoplasma pneumoniae acute infections, using serological testing, in patients admitted to the emergency department for acute exacerbations of chronic obstructive pulmonary disease (copd). | 2017 | 28062246 |
| infectious agents and neurodegenerative diseases: exploring the links. | recent studies have shown that bacterial and viral infections are risk factors for various neurodegenerative diseases such as amyotrophic lateral sclerosis (als), multiple sclerosis (ms), alzheimer's disease (ad), and lyme disease (ld). however, it is still controversial how the infections play a role in neurological diseases progression. infections in central nervous system may lead multiple damages in infected and neighboring cells. the infection leads to the activation of inflammatory process ... | 2017 | 28049398 |
| chlamydia pneumoniae induces interleukin-12 responses in peripheral blood mononuclear cells in asthma and the role of toll like receptor 2 versus 4: a pilot study. | chlamydia pneumoniae causes respiratory infection in adults and children, and has been associated with asthma exacerbations and induction of immunoglobulin (ig) e responses. we previously reported that c. pneumoniae enhances t helper (th) 2 responses of peripheral blood mononuclear cells (pbmc) from asthmatic patients. it is likely that toll like receptor (tlr)-2 and tlr-4 mediate cytokine responses and host defense against c. pneumoniae. thus, we sought to determine whether engagement of tlr-2 ... | 2016 | 28035483 |
| community-acquired pneumonia in the asia-pacific region. | community-acquired pneumonia (cap) is an important cause of mortality and morbidity worldwide. aging population, dense urbanization, and poor access to health care make the asia-pacific region vulnerable to cap. the high incidence of cap poses a significant health and economic burden in this region. common etiologic agents in other global regions including streptococcus pneumoniae, mycoplasma pneumoniae, haemophilus influenzae, chlamydophila pneumoniae, staphylococcus aureus, and respiratory vir ... | 2016 | 27960208 |
| role of atypical pathogens in the etiology of community-acquired pneumonia. | atypical pneumonia has been described for over 100 years, but some of the pathogens attributed to it have been identified only in the past decades. the most common pathogens are chlamydia pneumoniae, mycoplasma pneumoniae, and legionella pneumophila. the epidemiology and pathophysiology of these three pathogens have been studied since their discovery, and are reviewed herein to provide better insight when evaluating these patients, which hopefully translates into improved care. the incidence of ... | 2016 | 27960206 |
| chlamydial infections in wildlife-conservation threats and/or reservoirs of 'spill-over' infections? | members of the order chlamydiales are biphasic intracellular pathogens known to cause disease in both humans and animals. as we learn more about the genetic diversity of this group of pathogens, evidence is growing that these bacteria infect a broader range of animal hosts than previously thought. over 400 host species are now documented globally with the majority of these being wild animals. given the impact of chlamydial infections on humans and domesticated animals, the identification of memb ... | 2016 | 27939160 |
| role of chlamydia pneumoniae in the pathogenesis of hypertrophy and adenoid tissue inflammation in children. | a tropism to epithelial cells and lymphocytes, an inhibition of apoptosis in host cells, an ability to occurrence in persistent form resistant to antibiotic treatment are the features of chlamydia pneumoniae, which can have connection with chronic inflammation of an adenoid tissue and adenoid hypertrophy. this study aimed to (1) detect the c. pneumoniae in an adenoid in children undergoing adenoidectomy, (2) estimate a connection between c. pneumoniae occurrence and the size of adenoid, (3) demo ... | 2016 | 27935539 |
| lead discovery strategies for identification of chlamydia pneumoniae inhibitors. | throughout its known history, the gram-negative bacterium chlamydia pneumoniae has remained a challenging target for antibacterial chemotherapy and drug discovery. owing to its well-known propensity for persistence and recent reports on antimicrobial resistence within closely related species, new approaches for targeting this ubiquitous human pathogen are urgently needed. in this review, we describe the strategies that have been successfully applied for the identification of nonconventional anti ... | 2016 | 27916800 |
| is there any association between sarcoidosis and infectious agents?: a systematic review and meta-analysis. | during the last few years, investigators have debated the role that infectious agents may have in sarcoidosis pathogenesis. with the emergence of new molecular biology techniques, several studies have been conducted; therefore, we performed a meta-analysis in order to better explain this possible association. | 2016 | 27894280 |
| insights into structure and function of 30s ribosomal protein s2 (30s2) in chlamydophila pneumoniae: a potent target of pneumonia. | the gene 30s ribosomal protein s2 (30s2) is identified as a potential drug and vaccine target for pneumonia. its structural characterization is an important to understand the mechanism of action for identifying its receptor and/or other binding partners. the comparative genomics and proteomics studies are useful for structural characterization of 30s2 in c. pneumoniae using different bioinformatics tools and web servers. in this study, the protein 30s2 structure was modelled and validated by ram ... | 2017 | 27866051 |
| lack of association of chlamydia pneumoniae with cardiovascular diseases in virologically suppressed hiv patients. | cardiovascular disease (cvd) is a major public health problem in developed countries with over 17 million deaths per year. in the last decade, several infectious agents rather than any single pathogen, including chlamydia pneumoniae and human immunodeficiency virus (hiv), have been shown to contribute to the development of atherosclerosis and subsequent cardiovascular events by inducing systemic inflammation and/or acting directly on the vascular wall. for the first time, we evaluated c. pneumon ... | 2017 | 27819396 |
| progress and future opportunities in the development of vaccines against atherosclerosis. | atherosclerosis represents a serious global health problem that demands new therapeutic and prophylactic interventions. considering that atherosclerosis has autoimmune and inflammatory components, immunotherapy is a possible focus to treat this disease. areas covered: based on the analysis of the current biomedical literature, this review describes the status on the development of vaccines against atherosclerosis. several targets have been identified including sequences of apolipoprotein b100 (a ... | 2017 | 27817213 |
| prevalence and seasonal distribution of respiratory viruses during the 2014 - 2015 season in istanbul. | acute respiratory tract infection (arti) is one of the most common infections worldwide, causing significant morbidity and mortality. | 2016 | 27800148 |
| infectious burden and semen parameters. | to investigate the relationship between chronic infections detected in serum and semen quality. the pathogen burden is a concept consisting in the observation that, in patients with heart disease, damaging effects of the coronary arteries increase concomitantly with the number of agents responsible for chronic infections to which patients mounted a serological response. previous observations that helicobacter pylori infection may reduce the semen quality prompted us to perform the present study. | 2017 | 27793655 |
| simkania negevensis, an insight into the biology and clinical importance of a novel member of the chlamydiales order. | simkania negevensis is a chlamydia-related bacterium discovered in 1993 and represents the founding member of the simkaniaceae family within the chlamydiales order. as other chlamydiales, it is an obligate intracellular bacterium characterized by a biphasic developmental cycle. its similarities with the pathogenic chlamydia trachomatis and chlamydia pneumoniae make it an interesting bacterium. so far, little is known about its biology, but s. negevensis harbors various microbiological characteri ... | 2017 | 27786615 |
| respiratory microbes present in the nasopharynx of children hospitalised with suspected pulmonary tuberculosis in cape town, south africa. | lower respiratory tract infection in children is increasingly thought to be polymicrobial in origin. children with symptoms suggestive of pulmonary tuberculosis (ptb) may have tuberculosis, other respiratory tract infections or co-infection with mycobacterium tuberculosis and other pathogens. we aimed to identify the presence of potential respiratory pathogens in nasopharyngeal (np) samples from children with suspected ptb. | 2016 | 27776489 |
| association of chlamydia pneumoniae immunoglobulin g antibodies with the risk of lung cancer among non-smoking women in liaoning, china. | the role of chlamydia pneumoniae in the cause of lung cancer is controversial. in this study, we investigated the association between c. pneumoniae immunoglobulin (ig) g antibodies and risk of lung cancer among non-smoking women. c. pneumoniae igg antibody levels were compared between 192 adult chinese women who met the diagnostic criteria of lung cancer and 90 healthy controls. c. pneumoniae igg antibodies were tested with the use of an enzyme-linked immunosorbent assay. the prevalence of c. pn ... | 2010 | 27755800 |
| natural products for the treatment of chlamydiaceae infections. | due to the global prevalence of chlamydiae, exploring studies of diverse antichlamydial compounds is important in the development of effective treatment strategies and global infectious disease management. chlamydiaceae is the most widely known bacterial family of the chlamydiae order. among the species in the family chlamydiaceae, chlamydia trachomatis and chlamydia pneumoniae cause common human diseases, while chlamydia abortus, chlamydia psittaci, and chlamydia suis represent zoonotic threats ... | 2016 | 27754466 |
| to study the association between anti-chlamydia pneumoniae antibodies (igg), anti-mycoplasma pneumoniae antibodies (igg) and coronary artery disease (cad). | 2016 | 27727592 | |
| application of serology and nested polymerase chain reaction for identifying chlamydophila pneumoniae in community-acquired lower respiratory tract infections in children. | chlamydophila pneumoniae is a common cause of community-acquired respiratory infections, including pneumonia, bronchitis, and upper respiratory tract infections. since it is difficult to detect c. pneumoniae in clinical practice, specific etiological diagnosis is established only in a minority of cases. | 2017 | 27721281 |
| peptide 19 of porphyromonas gingivalis heat shock protein is a potent inducer of low-density lipoprotein oxidation. | although periodontal pathogens show a strong association with development of atherosclerosis, little is known about how a microorganism contributes to disease onset and progression. oxidation of low-density lipoprotein (ldl) is a major risk factor of atherogenesis. the principal objective of this study is to evaluate the ability of peptide 19 (pep19) of porphyromonas gingivalis (pg) heat shock protein (hsp) as a potent inducer of ldl oxidation, and a secondary objective is to compare this abilit ... | 2017 | 27712463 |
| coinfection of chlamydiae and other bacteria in reactive arthritis and spondyloarthritis: need for future research. | reactive (inflammatory) arthritis has been known for many years to follow genital infection with the intracellular bacterial pathogen chlamydia trachomatis in some individuals. recent studies from several groups have demonstrated that a related bacterium, the respiratory pathogen chlamydia pneumoniae, can elicit a similar arthritis. studies of these organisms, and of a set of gastrointestinal pathogens also associated with engendering inflammatory arthritis, have been relatively extensive. howev ... | 2016 | 27681924 |
| analysis of polymorphic membrane protein expression in cultured cells identifies pmpa and pmph of chlamydia psittaci as candidate factors in pathogenesis and immunity to infection. | the polymorphic membrane protein (pmp) paralogous families of chlamydia trachomatis, chlamydia pneumoniae and chlamydia abortus are putative targets for chlamydia vaccine development. to determine whether this is also the case for pmp family members of c. psittaci, we analyzed transcription levels, protein production and localization of several pmps of c. psittaci. pmp expression profiles were characterized using quantitative real-time pcr (rt-qpcr), immunofluorescence (if) and immuno-electron m ... | 2016 | 27631978 |
| recent advances and future directions in understanding and treating chlamydia-induced reactive arthritis. | reactive arthritis (rea) is an inflammatory disease that can follow gastrointestinal or genitourinary infections. the primary etiologic agent for post-venereal rea is the bacterium chlamydia trachomatis; its relative, c pneumoniae, has also been implicated in disease induction although to a lesser degree. studies have indicated that the arthritis is elicited by chlamydiae infecting synovial tissue in an unusual biologic state designated persistence. we review clinical aspects, host-pathogen inte ... | 2017 | 27627462 |
| investigating potential exogenous tumor initiating and promoting factors for cutaneous t-cell lymphomas (ctcl), a rare skin malignancy. | most skin malignancies are caused by external and often preventable environmental agents. multiple reports demonstrated that cutaneous t-cell lymphomas (ctcl) can occur in married couples and cluster in families. furthermore, recent studies document geographic clustering of this malignancy in texas as well as in other areas of the united states. multiple infectious, occupational, and medication causes have been proposed as triggers or promoters of this malignancy including hydrochlorothiazide di ... | 2016 | 27622024 |
| chlamydia pneumoniae cpj0783 interaction with huntingtin-protein14. | chlamydia pneumoniae is a gram-negative, obligate intracellular pathogen that causes community-acquired respiratory infections. after c. pneumoniae invades host cells, it disturbs the vesicle transport system to escape host lysosomal or autophagosomal degradation. by using a yeast mis-sorting assay, we found 10 c. pneumoniae candidate genes involved in aberrant vesicular trafficking in host cells. one of the candidate genes, cpj0783, was recognized by antibodies from c. pneumoniae-infected patie ... | 2015 | 27611675 |
| biophysical and biochemical outcomes of chlamydia pneumoniae infection promotes pro-atherogenic matrix microenvironment. | multiple studies support the hypothesis that infectious agents may be involved in the pathogenesis of atherosclerosis. chlamydia pneumoniae is strongly implicated in atherosclerosis, but the precise role has been underestimated and poorly understood due to the complexity of the disease process. in this work, we test the hypothesis that c. pneumoniae-infected macrophages lodged in the subendothelial matrix contribute to atherogenesis through pro-inflammatory factors and by cell-matrix interaction ... | 2016 | 27582738 |
| the chlamydia pneumoniae adhesin pmp21 forms oligomers with adhesive properties. | chlamydiae sp. are obligate intracellular pathogens that cause a variety of diseases in humans. the adhesion of chlamydiae to the eukaryotic host cell is a pivotal step in pathogenesis. the adhesin family of polymorphic membrane proteins (pmp) in chlamydia pneumoniae consists of 21 members. pmp21 binds to the epidermal growth factor receptor (egfr). pmps contain large numbers of fxxn (where x is any amino acid) and gga(i/l/v) motifs. at least two of these motifs are crucial for adhesion by certa ... | 2016 | 27551038 |
| chlamydia infection associated with asthma. | repeated or prolonged exposure to chlamydia pneumoniae may have a causal association with wheezing, asthmatic bronchitis and asthma. | 1991 | 27522900 |
| impact of micro-environmental changes on respiratory tract infections with intracellular bacteria. | community-acquired pneumonia is caused by intra- and extracellular bacteria, with some of these bacteria also being linked to the pathogenesis of chronic lung diseases, including asthma and chronic obstructive pulmonary disease. chlamydia pneumoniae is an obligate intracellular pathogen that is highly sensitive to micro-environmental conditions controlling both pathogen growth and host immune responses. the availability of nutrients, as well as changes in oxygen, ph and interferon-γ levels, have ... | 2016 | 27509029 |
| viral etiology in adult influenza-like illness/acute respiratory infection and predictivity of c-reactive protein. | influenza-like illness (ili) and acute respiratory infection (ari) are common presentations during winter and indiscriminate antibiotic use contributes significantly to the emerging post-antibiotic era. | 2016 | 27482806 |
| signaling events in pathogen-induced macrophage foam cell formation. | macrophage foam cell formation is a key event in atherosclerosis. several triggers induce low-density lipoprotein (ldl) uptake by macrophages to create foam cells, including infections with porphyromonas gingivalis and chlamydia pneumoniae, two pathogens that have been linked to atherosclerosis. while gene regulation during foam cell formation has been examined, comparative investigations to identify shared and specific pathogen-elicited molecular events relevant to foam cell formation are not w ... | 2016 | 27481727 |
| isolation of chlamydia abortus from a laboratory worker diagnosed with atypical pneumonia. | identifying the aetiological agent of atypical pneumonia in human can sometimes be a tedious process, especially in cases where mycoplasma pneumoniae, legionella species and chlamydia pneumoniae are ruled out. in such cases, a correct anamnesis of the patient is basic to clarify which pathogens might have produced the infection. for this reason, health professionals including veterinarians and laboratory personnel working with zoonotic pathogens should keep their doctors informed. | 2015 | 27446530 |
| [community acquired pneumonia - treatment options according to the international recommendations]. | pneumonia remains one of the main reasons of heath care system utilization. quick diagnosis and prompt treatment initiation determine favorable outcome. empirical antibiotic treatment allows to achieve treatment success in most patients. treatment recommendations are based on big epidemiological trials. nevertheless, it is sometimes necessary to know the definite etiologic factor of pneumonia. in these cases microbiological diagnostics is useful, i.e. sputum microscopy and culture, blood culture ... | 2016 | 27421128 |
| [distribution characteristics of mycoplasma pneumoniae, chlamydia pneumoniae, and legionella pneumophila in hospitalized children with acute respiratory tract infection: an analysis of 13 198 cases]. | to investigate the distribution characteristics of mycoplasma pneumoniae (mp), chlamydia pneumoniae (cp), and legionella pneumophila (lp) in hospitalized children with acute respiratory tract infection (arti). | 2016 | 27412543 |
| serological evidence of chronic chlamydia pneumoniae infection in coronary artery disease. | recent studies have suggested that chlamydia pneumoniae infection could be involved in atherosclerosis and related clinical manifestations such as coronary artery disease, carotid artery stenosis and myocardial infarction. | 2007 | 27408004 |
| chronic infection and severe asthma. | chronic bacterial infection is implicated in both the development and severity of asthma. the atypical bacteria mycoplasma pneumoniae and chlamydophila pneumoniae have been identified in the airways of asthmatics and correlated with clinical features such as adult onset, exacerbation risks, steroid sensitivity, and symptom control. asthmatic patients with evidence of bacterial infection may benefit from antibiotic treatment directed towards these atypical organisms. examination of the airway mic ... | 2016 | 27401621 |
| tryptophan codon-dependent transcription in chlamydia pneumoniae during gamma interferon-mediated tryptophan limitation. | in evolving to an obligate intracellular niche, chlamydia has streamlined its genome by eliminating superfluous genes as it relies on the host cell for a variety of nutritional needs like amino acids. however, chlamydia can experience amino acid starvation when the human host cell in which the bacteria reside is exposed to interferon gamma (ifn-γ), which leads to a tryptophan (trp)-limiting environment via induction of the enzyme indoleamine-2,3-dioxygenase (ido). the stringent response is used ... | 2016 | 27400720 |
| relapses of primary cutaneous anaplastic large-cell lymphoma in a female immunocompetent patient with persistent chlamydophila pneumoniae and human herpesvirus 8 infection. | we have previously reported the case of an immunocompetent female patient with a primary cutaneous cd30+ anaplastic large-cell lymphoma (pcalcl) located on her upper right eyelid characterized by the presence of a concurrent active infection by c. pneumoniae and human herpesvirus 8 (hhv8). this finding suggested for the first time a possible association of c. pneumoniae and/or hhv8 infection, or both together, with pcalcl pathogenesis in non-immunocompromised and hiv-negative subjects. the subse ... | 2016 | 27382410 |
| the prevalence of chlamydia pneumoniae in the aortic wall and in peripheral blood of patients scheduled for coronary artery bypass grafting. | some reports confirm a potential role of chlamydia pneumoniae (chp) in atherogenesis. in order to explore possible association between chp and atherosclerosis, investigations were carried out in which the frequency of chp in the arterial wall and peripheral blood was assessed in a group of patients with chronic coronary artery disease (cad). fifty-seven patients were enrolled in the study, 13 women and 44 men aged 61.8±6.5 (47-74), with previously diagnosed cad, scheduled for planned coronary ar ... | 2016 | 27358129 |