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molecular identification of cryptosporidium isolates from ill exotic pet animals in japan including a new subtype in cryptosporidium fayeri.cryptosporidium is an obligate intracellular parasite which can cause fatal diarrheal disease in exotic animals. sugar gliders (petaurus breviceps), hedgehogs (atelerix albiventris), chinchillas (chinchilla lanigera), and common leopard geckos (eublepharis macularius) are popular exotic animals commonly sold in pet shops in japan. we herein investigated the species and subtypes of cryptosporidium in these animals. cryptosporidium fayeri was detected in a sugar glider in a japanese animal hospita ...202032862916
chinchilla (chinchilla lanigera) behavioral responses to a visual signal preceding handling.zoos use ambassador animals in educational programs featuring close contact with humans. chinchillas (chinchilla lanigera) at the saint louis zoo are retrieved for programs by a keeper wearing brown handling gloves, but green cleaning gloves are worn during normal husbandry when physical contact with the animal is only incidental. the chinchillas' primary keeper anecdotally reported more reactivity and movement from chinchillas when approached with handling gloves. animals' behavioral reactions ...202032754909
diagnosis, surveillance and management of streptococcus equi subspecies zooepidemicus infections in chinchillas (chinchilla lanigera).during a 6-mo period, two 5-6 mo old female chinchillas (chinchilla lanigera) were examined at the university of colorado anschutz medical campus after the discovery of firm, nonmobile masses in the left ventral cervical and left axillary region. other than these findings and mild weight loss, both chinchillas' physical exams were normal. bloodwork revealed an inflammatory leukogram characterized by leukocytosis, toxic neutrophils, lymphopenia, and monocytosis with mild, nonregenerative anemia. ...202032731906
update on diseases in chinchillas: 2013-2019.chinchillas have been used mostly as fur animals and as animal models for human ontological diseases and only recently have been recognized as excellent, long-lived, and robust pet rodents. this review aims to provide updated information on emerging disease conditions in pet chinchillas, such as streptococcus equi subsp zooepidemicus and pseudomonas aeruginosa. furthermore, this review article provides updated information on previously documented disorders, such as urolithiasis and middle ear di ...202032327039
cholinergic and adrenergic innervation of the pancreas in chinchilla (chinchilla laniger molina).cholinergic and adrenergic innervation of the pancreas in chinchilla (chinchilla laniger molina) was examined in this study. the pancreas is both an exocrine and endocrine gland with autonomic and sensory innervation presented by the numerous nerve fibers and small agglomerations of nerve cells.202032202307
the moraxella catarrhalis phase-variable dna methyltransferase modm3 is an epigenetic regulator that affects bacterial survival in an in vivo model of otitis media.moraxella catarrhalis is a leading cause of otitis media (om) and chronic obstructive pulmonary disease (copd). m. catarrhalis contains a type iii dna adenine methyltransferase (modm) that is phase-variably expressed (i.e., its expression is subject to random, reversible on/off switching). modm has six target recognition domain alleles (modm1-6), and we have previously shown that modm2 is the predominant allele, while modm3 is associated with om. phase-variable dna methyltransferases mediate epi ...201931818247
establishing an animal model of single-sided deafness in chinchilla lanigera.(1) to characterize changes in brainstem neural activity following unilateral deafening in an animal model. (2) to compare brainstem neural activity from unilaterally deafened animals with that of normal-hearing controls.201931570054
the effect of fish and mealworm larvae meals as alternative dietary protein sources on nutrient digestibility and gastrointestinal function in chinchilla lanigera.chinchillas are herbivores, but wild chinchillas may occasionally consume animal-based foods. the aim of this study was to determine the effect of fish meal (fm) and mealworm meal (mwm) included in complete pelleted diets on nutrient digestibility and gastrointestinal function in chinchillas. the experiment was performed on 24 male, divided into three groups, n=8. control group (c) was fed a diet containing 10% soybean meal (sbm). in the experimental group fm, chinchillas received a diet contain ...202031527335
in silico modeling of biofilm formation by nontypeable haemophilus influenzae in vivo.biofilms formed by nontypeable haemophilus influenzae (nthi) bacteria play an important role in multiple respiratory tract diseases. visual inspection of the morphology of biofilms formed during chronic infections shows distinct differences from biofilms formed in vitro to better understand these differences, we analyzed images of nthi biofilms formed in the middle ears of chinchilla lanigera and developed an in silico agent-based model of the formation of nthi biofilms in vivo we found that, as ...201931366707
between-ear sound frequency disparity modulates a brain stem biomarker of binaural hearing.the auditory brain stem response (abr) is an evoked potential that indexes a cascade of neural events elicited by sound. in the present study we evaluated the influence of sound frequency on a derived component of the abr known as the binaural interaction component (bic). specifically, we evaluated the effect of acoustic interaural (between-ear) frequency mismatch on bic amplitude. goals were to 1) increase basic understanding of sound features that influence this long-studied auditory potential ...201931314646
noninvasive ultrasound monitoring of embryonic and fetal development in chinchilla lanigera to predict gestational age: preliminary evaluation of this species as a novel animal model of human pregnancy.ultrasound is a noninvasive routine method that allows real-time monitoring of fetal development in utero to determine gestational age and to detect congenital anomalies and multiple pregnancies. to date, the developmental biology of chinchilla lanigera has not yet been characterized. this species has been found to undergo placentation, long gestation, and fetal dimensions similar to those in humans. the aim of this study was to assess the use of high-frequency ultrasound (hfus) and clinical ult ...201931263384
infrared thermography as an indicator of heat loss in fur-chewing chinchillas (chinchilla lanigera).fur-chewing is a common problem in chinchilla (chinchilla lanigera). it may affect the welfare of animals due to heat loss, thereby possibly impacting food and water intake to maintain body temperature. in this context, infrared thermography seems to be a suitable method of measuring heat emissions from the surface of objects. sexually mature male domestic chinchillas were divided into two groups: "non-fur chewers", exhibiting normal behaviour (n = 25), and "fur chewers" displaying fur-chewing b ...202031095420
morphological and morphometrical study of the auditory ossicles in chinchilla.this study is meant to illustrate and describe the features of the auditory ossicles of the chinchilla (chinchilla lanigera), one of the species used more and more frequently in otology and ear surgery as animal model. cephalic extremities of 12 c. lanigera individuals obtained from a private farm, where this species was bred for fur, were used in this study. the ossicles were obtained either by direct surgical harvesting by mastoid approach or after a dermestid beetle exposure followed by anato ...201931041818
endoparasites of domesticated animals that originated in the neo-tropics (new world tropics).this review serves to summarize parasites found in domesticated animals which were found in the neo-tropics. indigenous domesticated neo-tropical animals include south american camelids, (lama gunacoa, lama glama, lama pacos, vicuna vicuna), guinea pigs (cavia porcellus), chinchillas (chinchilla lanigera), turkeys (meleagris gallopavo) and ducks (cairina moschata, anas platyrhynchos, dendrocyga autumnalis). these animals were chosen due to their origin of existence (neo-tropics) and over time th ...201930845667
some segmental morphological and morphometrical features of the intima and media of the aortic wall in chinchilla lanigera.the aim of this study is to describe the morphology, morphometry and ultrastructure of segments of the thoracic and abdominal aorta portions in chinchilla lanigera. thickness measurements of the tunica intima and media complex of the aorta were taken.201930835342
mandible strength and geometry in relation to bite force: a study in three caviomorph rodents.the monophyletic group caviomorpha constitutes the most diverse rodent clade in terms of locomotion, ecology and diet. caviomorph species show considerable variation in cranio-mandibular morphology that has been linked to the differences in toughness of dietary items and other behaviors, such as chisel-tooth digging. this work assesses the structural strength of the mandible of three caviomorph species that show remarkable differences in ecology, behavior and bite force: chinchilla lanigera (a s ...201930768871
perception of degraded speech by chinchillas (chinchilla laniger): word-level stimulus generalization.one characteristic of human speech perception is a remarkable ability to recognize speech when the speech signal is highly degraded. it has been argued that this ability to perceive highly degraded speech reflects speech-specific mechanisms. the present study tested this hypothesis by measuring the ability of chinchillas to recognize noise-vocoded (nv) versions of naturally spoken monosyllabic words using operant conditioning in a stimulus generalization paradigm. chinchillas do not generalize t ...201930589293
mutations in bacterial genes induce unanticipated changes in the relationship between bacterial pathogens in experimental otitis media.otitis media (om) is a common polymicrobial infection of the middle ear in children under the age of 15 years. a widely used experimental strategy to analyse roles of specific phenotypes of bacterial pathogens of om is to study changes in co-infection kinetics of bacterial populations in animal models when a wild-type bacterial strain is replaced by a specific isogenic mutant strain in the co-inoculating mixtures. as relationships between the om bacterial pathogens within the host are regulated ...201830564392
pleomorphic iridociliary adenocarcinoma with metastasis to the cervical lymph node in a chinchilla (chinchilla lanigera).a tumor had formed in the right eye of a 14-year-old male chinchilla. the black-and-white-colored tumor occupied the entire eye except for the lens and had invaded extensively inside the orbit. histologically, round, spindle- to polygonal-shaped tumor cells had proliferated in a solid-sheet arrangement. the tumor cells exhibited polymorphic nuclei ranging from round- to polygonal-shaped, as well as abundant cytoplasm, which occasionally contained melanin granules. in some areas, several cells we ...201930555123
molecular and histopathological features of cryptosporidium ubiquitum infection in imported chinchillas chinchilla lanigera in japan.long-tailed chinchillas chinchilla lanigera are popular rodent species kept both in households, where they are hand-raised as pets, and in zoological facilities. from january 2016 to february 2017, 13 juvenile chinchillas from five facilities in japan were diagnosed with cryptosporidiosis at the animal hospital. eight of the cases were fatal. all of the animals were imported from the czech republic by the same vendor. histopathological and multilocus sequence analyses using 18s ribosomal rna, ac ...201930240872
infrared technology for estrous detection in chinchilla lanigera.thermography is one of the most modern methods for non-invasive monitoring of animal behavior, health status and physiological state. the sparcity of scientific reports related to this subject in fur animals prompted the use of thermography in chinchilla lanigera. the aim of the study was to evaluate the use of a thermal imaging camera to diagnose or confirm estrus in chinchilla lanigera. the subjects included 100 female chinchillas from three different breeds, selected during ovulation after pa ...201830143279
determination of the genetic component of fur-chewing in chinchillas (chinchilla lanigera) and its economic impact.fur-chewing is a common behavioral disorder developed by chinchillas kept in confinement that can indicate a past or present welfare problem. it also has a negative productive impact associated. the aim of this study was to determine the genetic component of fur-chewing, and the effect of this undesired behavior on fur price in a commercial fur-farming system of chinchillas (chinchilla lanigera). the data for the analysis was derived from a commercial population of 10,196 chinchillas, recorded b ...201830134521
vaginal leiomyoma in a chinchilla (chinchilla laniger). 201829964294
diaphragmatic hernia in a pet chinchilla (chinchilla lanigera).a 10-year-old pet chinchilla (chinchilla lanigera) was referred for ultrasound investigation of a thoracic mass. the mass was initially believed to be a pulmonary abscess or tumor based on radiographs and ultrasound. cytological examination suggested the presence of a gastrointestinal structure in the thorax, and necropsy revealed a true diaphragmatic hernia subdividing the stomach into thoracic and abdominal portions.201829904206
contrary to popular belief, chinchillas do not have a pure rod retina.to establish whether there is cone contribution to retinal function and structure in chinchillas (chinchilla lanigera), in view of the prevailing notion that this species possesses a pure rod retina.201929888430
analgesic efficacy and safety of hydromorphone in chinchillas (chinchilla lanigera).limited information is available regarding the efficacy of opioid analgesics in chinchillas. here we sought to evaluate the analgesic efficacy and safety of hydromorphone in chinchillas. in a randomized, controlled, blind, complete crossover design, hydromorphone was administered at 0.5, 1, and 2 mg/kg sc to 16 chinchillas. analgesic efficacy was determined by measuring hindlimb withdrawal latencies after a thermal noxious stimulus (hargreaves method) at 0, 1, 2, 4, and 8 h after drug administra ...201829784079
analgesic efficacy and safety of buprenorphine in chinchillas (chinchilla lanigera).buprenorphine is routinely used in chinchillas at reported doses of 0.01 to 0.1 mg/kg im or sc. however, these dose recommendations are based on anecdotal reports or extrapolation from studies in other species. therefore, the purpose of this study was to evaluate the analgesic efficacy and safety of subcutaneously administered buprenorphine in chinchillas. using a randomized, blind, controlled, complete crossover design, we evaluated buprenorphine at a single dose of 0.05, 0.1 or 0.2 mg/kg sc (e ...201829690955
oviduct morphology and estrogen receptors erα and erβ expression in captive chinchilla lanigera (hystricomorpha: chinchillidae).chinchilla lanigera is a hystricomorph rodent from south america whose reproductive biology presents particular characteristics that distinguishes it from other rodentia species, such as low reproductive rate, seasonal breeding pattern, and long estrous cycle. nevertheless, reproductive features in female chinchillas are still poorly investigated, with a scarce knowledge concerning the estrous cycle and the histology of reproductive organs. in this study, we investigate the morphology, histomorp ...201929574151
occurrence of giardia duodenalis assemblages in farmed long-tailed chinchillas chinchilla lanigera (rodentia) from romania.giardia duodenalis is a parasitic protist that infects a large number of species, being localized in the small intestine. two of the eight recognized assemblages have zoonotic potential, but studies regarding their distribution in less important pet or farm species are scarce. of these species, the long-tailed chinchilla is a host for giardia spp., although data on the spread of infection and assemblages involved are confined. the present work aimed to determine the prevalence of giardia infecti ...201829415759
partial aminoglycoside lesions in vestibular epithelia reveal broad sensory dysfunction associated with modest hair cell loss and afferent calyx retraction.although the effects of aminoglycoside antibiotics on hair cells have been investigated for decades, their influences on the dendrites of primary afferent neurons have not been widely studied. this is undoubtedly due to the difficulty in disassociating pathology to dendritic processes from that resulting from loss of the presynaptic hair cell. this was overcome in the present investigation through development of a preparation using chinchilla laniger that enabled direct perilymphatic infusion. t ...201729163044
neurological examination in healthy chinchillas ( chinchilla lanigera).chinchillas are popular as laboratory models and companion animals, and they can be affected by a variety of infectious and non-infectious neurological diseases. little information is available on making a neurological diagnosis in this species, in part because the neurological examination has not been standardized in chinchillas and the expected physiological findings in healthy chinchillas have not been reported. in this study, a standardized neurological examination was performed on 30 clinic ...201729160177
vertebral heart size in chinchillas (chinchilla lanigera) usingradiography and ct.to determine the vertebral heart size in chinchillas using right and left lateral radiographic views and ct images. to evaluate the agreement between radiographic and ct modalities.201728833200
comparison of rectal and tympanic thermometry in chinchillas (chinchilla lanigera).objective to evaluate the effects of restraint time and thermometer insertion depth on rectal temperature measurements in chinchillas and determine the extent of agreement between temperatures measured with 2 tympanic and a rectal thermometer. design prospective method comparison study. animals 47 healthy chinchillas. procedures effects of 1- and 2-cm rectal thermometer insertion depths and the effect of manual restraint for up to 5 minutes were evaluated. near simultaneous temperature measureme ...201728828954
diaphragmatic hernia in a pet chinchilla (chinchilla lanigera).a 10-year-old pet chinchilla (chinchilla lanigera) was referred for ultrasound investigation of a thoracic mass. the mass was initially believed to be a pulmonary abscess or tumor based on radiographs and ultrasound. cytological examination suggested the presence of a gastrointestinal structure in the thorax, and necropsy revealed a true diaphragmatic hernia subdividing the stomach into thoracic and abdominal portions.201728588332
adrenergic and cholinergic innervation of the atrioventricular valves in chinchilla (chinchilla laniger).the arrangement of autonomous fibres was studied in the cardiac atrioventricular valves of small chinchillas. the dissected valves were stained entirely using the modified histochemical acetylcholine esterase technique (ache) and the spg-de la torre method. double immunocytochemical staining was also used for the expression of vesicular acetylcholine transporter (vacht) and dopamine β hydroxylase (dbh). the study showed the presence of both cholinergic and adrenergic fibres, forming a kind of ne ...201728553858
the chinchilla as a novel animal model of pregnancy.several parameters are important when choosing the most appropriate animal to model human obstetrics, including gestation period, number of fetuses per gestation and placental structure. the domesticated long-tailed chinchilla (chinchilla lanigera) is a well-suited and appropriate animal model of pregnancy that often will carry only one offspring and has a long gestation period of 105-115 days. furthermore, the chinchilla placenta is of the haemomonochorial labyrinthine type and is therefore com ...201728484627
first description of cryptosporidium ubiquitum xiia subtype family in farmed fur animals.this study investigated the prevalence of cryptosporidium in farmed fur animals in the czech republic and poland. a total of 480 faecal samples were collected from fur animals, including 300 american mink (mustela vison), 60 silver foxes (vulpes vulpes), 50 long-tailed chinchillas (chinchilla lanigera), and 70 nutrias (myocastor coypus), at 14 farms. samples were examined for the presence of cryptosporidium using microscopy (following aniline-carbol-methyl violet staining) and sequence analysis ...201728482327
anesthetic and postanesthetic effects of alfaxalone-butorphanol compared with dexmedetomidine-ketamine in chinchillas (chinchilla lanigera).effective and safe anesthetic protocols are required for a variety of surgical and diagnostic procedures in chinchillas.alfaxalone, a new anesthetic agent in the united states, can be administered intramuscularly and subcutaneously and is therefore potentially useful as an anesthetic induction agent in chinchillas. this study compared the anesthetic efficacy andpostanesthetic effects on food intake and fecal output of a combination of intramuscular alfaxalone (5 mg/kg) and butorphanol(0.5 mg/kg; ...201728432759
tonometer validation and intraocular pressure reference values in the normal chinchilla (chinchilla lanigera).to determine accuracy and precision of three commonly used tonometers (tonovet(®) and tonolab(®) (icare oy, finland)-rebound tonometers, and tono-pen vet™ (reichert, ny)-applanation tonometer) in normal chinchillas, and to establish a normal intraocular pressure (iop) reference range in this species.201728303681
epidemiology of bacterial conjunctivitis in chinchillas (chinchilla lanigera): 49 cases (2005 to 2015).to evaluate the anamnesis, clinical signs, diagnostic test results, treatment and outcome of chinchillas diagnosed with bacterial conjunctivitis.201728276116
morphometry and variability of the brain arterial circle in chinchilla (chinchilla laniger, molina).arterial circles of brains from 70 adult chinchillas were filled with synthetic latex. the arterial circle of the brain is formed as the result of vertebral arteries being merged into the basilar artery. caudally, both vertebral arteries gave rise to the ventral spinal artery. the ventral spinal artery splits into tiny cerebellar vessels, the pontine and cochlear branches. distally, the basilar artery ramified into two terminal branches that formed the arterial circle of brain, rostrally open in ...201728181413
midbrain frequency representation following moderately intense neonatal sound exposure in a precocious animal model (chinchilla laniger).auditory brain areas undergo reorganization resulting from abnormal sensory input during early postnatal development. this is evident from studies at the cortical level but it remains unclear whether there is reorganization in the auditory midbrain in a species similar to the human, that is, with early hearing onset. we have explored midbrain plasticity in the chinchilla, a precocious species that matches the human in terms of hearing development. neonatal chinchillas were chronically exposed to ...201627895941
surgical management of multiple metatarsal fractures in a chinchilla (chinchilla lanigera).case description a 3-month-old sexually intact female chinchilla (chinchilla lanigera) was examined for sudden onset of non-weight-bearing lameness of the right hind limb. clinical findings on physical examination, the right pes was swollen. an open wound on the medial aspect of the metatarsal region exposed the second metatarsal bone, and the pes was displaced laterally. radiographs of the right pes revealed oblique displaced fractures of the 4 metatarsal bones. treatment and outcome surgical t ...201627654167
cloning and sequence analysis of wild argali splunc1 cdna.the complete coding sequence of wild argali splunc1 cdna was generated by rapid amplification of cdna ends. the splunc1 cdna was 1076 bp with an open reading frame of 768 bp, which encoded a 26.49 kda protein composed of 255 amino acids. its amino acid sequence shared 98.4%, 96.9%, 94.5%, 90.2%, 80.8 %, 78.4%, 78.3%, 72.5%, 72.3%, 68.8% identity with those of splunc1 cdna from ovis aries (accession no. np_001288334.1), capra hircus (accession no. xp_005688516.1), pantholops hodgsonii (accession ...201627620892
anatomy and disorders of the oral cavity of chinchillas and degus.dental disease is among the most common causes for chinchillas and degus to present to veterinarians. most animals with dental disease present with weight loss, reduced food intake/anorexia, and drooling. degus commonly present with dyspnea. dental disease has been primarily referred to as elongation and malocclusion of the cheek teeth. periodontal disease, caries, and tooth resorption are common diseases in chinchillas, but are missed frequently during routine intraoral examination, even perfor ...201627497209
echocardiographic effects of dexmedetomidine-ketamine in chinchillas ( chinchilla lanigera).alpha2-agonist anesthetic combinations are often used in rodent anesthesia but no information about their effects on cardiac function in chinchillas exists. the purpose of this study was to utilize echocardiography to evaluate the cardiovascular effects of dexmedetomidine-ketamine anesthesia in chinchillas. echocardiographic examinations were performed in eight adult chinchillas under manual restraint and following dexmedetomidine (0.015 mg/kg) and ketamine (4 mg/kg) administration. dexmedetomid ...201727368710
concurrent infection with mycobacterium avium subsp. hominissuis and giardia duodenalis in a chinchilla (chinchilla lanigera f. dom.).a 3-year-old, female chinchilla (chinchilla lanigera f. dom.) suffered from prolonged vaginal discharge. sonographically, multiple nodules were detected in the uterus, and the lung showed a diffuse radiodensity. ovario-hysterectomy was performed and histology of the uterus revealed a severe multifocal pyogranulomatous metritis with myriads of acid-fast rod-shaped bacilli. microbiological culture of formalin-fixed uterine tissue and a native vaginal swab resulted in the growth of mycobacteria tha ...201627344917
comparison of dexmedetomidine-ketamine with isoflurane for anesthesia of chinchillas (chinchilla lanigera).the objective of this study was to compare isoflurane with a combination of dexmedetomidine and ketamine, administered intramuscularly, for anesthesia in chinchillas (chinchilla lanigera). in a prospective, complete crossover study, adult chinchillas (n = 8; age, 2 to 5 y) were anesthetized with a combination of dexmedetomidine (0.015 mg/kg im) and ketamine (4 mg/kg im). atipamezole (0.15 mg/kg) was injected subcutaneously 45 min after dexmedetomidine-ketamine administration. for comparison, ane ...201627177565
the chinchilla research resource database: resource for an otolaryngology disease model.the long-tailed chinchilla (chinchilla lanigera) is an established animal model for diseases of the inner and middle ear, among others. in particular, chinchilla is commonly used to study diseases involving viral and bacterial pathogens and polymicrobial infections of the upper respiratory tract and the ear, such as otitis media. the value of the chinchilla as a model for human diseases prompted the sequencing of its genome in 2012 and the more recent development of the chinchilla research resou ...201627173523
histological and morphometric study of the epididymus of chinchilla lanigera grey under controlled conditions in captivity.chinchilla lanigera, native to the andean mountains of perú, chile, bolivia and argentina, is a specimen of great economic importance because of its fur. in mammals, spermatozoa originate in testes and are transported to the epididymis, where they undergo morphological and biochemical modifications known as sperm maturation, a basic step in the acquisition of their fertilizing ability. the aim of this work is the macroscopic and microscopic analysis of the epididymis of chinchilla lanigera grey ...201627172053
urinalysis in chinchillas (chinchilla lanigera).to evaluate urine variables in chinchillas (chinchilla lanigera).201627031416
influence of selected extenders for liquid storage at 4 degrees c of breeding chinchilla (chinchilla lanigera) semen on sperm dna integrity.the influence of two commercial and two laboratory oriented extenders on survival rate and dna integrity of chinchilla (chinchilla lanigera) sperm was determined during liquid storage. semen was collected using an electroejaculator from 6 adult male chinchillas. ejaculates (n = 16) were diluted with extenders to obtain a concentration of 40 x 10 (3) sperm/5 μl. after dilution the semen samples were stored at 4"c. the percent motility, progressive motility, and morphology were assessed convention ...201526975143
retention of solute and particle markers in the digestive tract of chinchillas (chinchilla laniger).the chinchilla (chinchilla laniger) is a herbivorous hystricomorph south american rodent for which no mean digesta retention times have been reported so far. six animals (mean body mass ± standard deviation: 513 ± 99 g) on a diet of grass hay and lucerne-based pellets were given a pulse dose of a solute (cobalt-edta) and a particle (chromium-mordanted fibre, <2 mm) marker with subsequent frequent faecal collection. dry matter intake was 45.2 ± 8.0 g/kg(0.75) /day. mean retention times were 22.2  ...201626857102
involvement of protein camp-dependent kinase, phospholipase a2 and phospholipase c in sperm acrosome reaction of chinchilla lanigera.the mechanisms involved in fertilization are the centre of attention in order to determine the conditions required to reproduce in vitro the events that take place in vivo, with special interest in endangered species. previous data from mouse sperm, where acrosome reaction (ar) occurs more often in the interstitium of the cumulus oophorus, contribute to strengthen the use of progesterone as a physiological inducer of this process. we studied the participation of protein kinase a (pka), phospholi ...201626699205
survey of hymenolepis spp. in pet rodents in italy.we carried out the first survey of hymenolepis spp. infection in pet rodents in italy. fresh fecal samples were collected from 172 pet rodents as follows: guinea pigs (cavia porcellus; n = 60), squirrels (callosciurus finlaysonii, callosciurus prevosti, tamias striatus, tamias sibiricus, sciurus calorinensis; n = 52), hamsters (phodopus campbelli, mesocricetus auratus; n = 30), chinchillas (chinchilla lanigera; n = 13), rats (rattus norvegicus; n = 10), and mice (mus minutoides; n = 7). these an ...201526290218
zoonotic cryptosporidium spp. and enterocytozoon bieneusi in pet chinchillas (chinchilla lanigera) in china.cryptosporidium and enterocytozoon bieneusi are the most prevalent protist pathogens responsible for inducing human and animal diseases worldwide. the aim of the present work was to determine the occurrence of cryptosporidium spp. and e. bieneusi in pet chinchillas in china. one hundred forty fecal samples were collected from four cities: beijing, zhengzhou, anyang and guiyang. they were then examined with pcr amplification of the small subunit ribosomal rna (ssu rrna) of cryptosporidium spp. an ...201525988830
sound frequency-invariant neural coding of a frequency-dependent cue to sound source location.the century-old duplex theory of sound localization posits that low- and high-frequency sounds are localized with two different acoustical cues, interaural time and level differences (itds and ilds), respectively. while behavioral studies in humans and behavioral and neurophysiological studies in a variety of animal models have largely supported the duplex theory, behavioral sensitivity to ild is curiously invariant across the audible spectrum. here we demonstrate that auditory midbrain neurons ...201525972580
organic matter and macromineral digestibility in domestic rabbits (oryctolagus cuniculus) as compared to other hindgut fermenters.it is generally assumed that animal species differ in physiological characteristics of their digestive tract. because investigating digestive processes is often labour-intensive, requiring lengthy adaptation and collection periods, comparisons are often made on the basis of data collated from different studies. we added a new data set on dietary crude fibre (cf) and macromineral (na, k, ca, p, mg) composition and apparent digestibility (ad) of organic matter (om) and macrominerals in rabbits (or ...201525857396
stronger efferent suppression of cochlear neural potentials by contralateral acoustic stimulation in awake than in anesthetized chinchilla.there are two types of sensory cells in the mammalian cochlea, inner hair cells, which make synaptic contact with auditory-nerve afferent fibers, and outer hair cells that are innervated by crossed and uncrossed medial olivocochlear (moc) efferent fibers. contralateral acoustic stimulation activates the uncrossed efferent moc fibers reducing cochlear neural responses, thus modifying the input to the central auditory system. the chinchilla, among all studied mammals, displays the lowest percentag ...201525784861
non-invasive endocrine monitoring of ovarian and adrenal activity in chinchilla (chinchilla lanigera) females during pregnancy, parturition and early post-partum period.the chinchilla is a rodent that bears one of the finest and most valuable pelts in the world. the wild counterpart is, however, almost extinct because of a drastic past and ongoing population decline. the present work was developed to increase our knowledge of the reproductive physiology of pregnancy and post-partum estrus in the chinchilla, characterizing the endocrine patterns of urinary progesterone, estradiol, lh and cortisol metabolites throughout gestation and post-partum estrus and estima ...201525712434
multilocus genotyping of potentially zoonotic giardia duodenalis in pet chinchillas (chinchilla lanigera) in china.giardia duodenalis is a common protozoan that colonizes and reproduces in the small intestine, causing giardiasis. this parasite infects a wide range of vertebrate hosts, including humans, domestic animals and wildlife. it has been suggested that chinchillas (chinchilla lanigera) kept as domestic pets are potential reservoirs for the zoonotic transmission of g. duodenalis. in this study, 140 chinchilla samples from four cities in china were examined to determine the prevalence of g. duodenalis. ...201525704655
specular microscopy to determine corneal endothelial cell morphology and morphometry in chinchillas (chinchilla lanigera) in vivo.the purpose of this study was to measure cell density, average area, and morphology of corneal endothelium of chinchillas in different age groups.201525469785
diagnosis of an outbreak of salmonella typhimurium in chinchillas (chinchilla lanigera) by pulsed-field gel electrophoresis.adult chinchillas (chinchilla lanigera) that had suddenly died in a commercial farm located in la plata city, buenos aires province, argentina, in july 2012 were macroscopically, histopathologically, and microbiologically examined. salmonella enterica serovar typhimurium (s. typhimurium) was isolated from the liver, spleen, heart, lungs, kidneys and intestines from each of the five animals evaluated. the five strains were susceptible to ampicillin, cephalotin, cefotaxime, nalidixic acid, gentami ...201425444129
acrosome reaction in the epididymal sperm of chinchilla lanigera. effect of progesterone, a23187 and stimulation of a gabaa-like receptor.little is known about the reproductive biology of chinchilla lanigera in captivity. currently there are no parameters to evaluate the quality of the semen of males that are sold as breeding stock, so they are selected according to their phenotypic characteristics, which cannot guarantee their reproductive efficiency. we worked with sexually mature males; the sperm were collected from the cauda epididymis by puncture. capacitated sperm were incubated at 37 °c with different concentrations of prog ...201225363576
experimental model of tympanic colic (acute abdomen) in chinchillas (chinchilla lanigera).digestive disorders caused by sudden changes in diet or inappropriate diet are among the most common disorders of the digestive system. cecal or intestinal tympany, one consequence of inappropriate diet, is characterized by the accumulation of gases, marked distension of the cecum and colon and the induction of inflammatory processes. to know the effects of intestinal tympany on the enteric plexuses, we developed a method of experimental tympanic colic (tc) in the chinchilla lanigera. this speci ...201425324875
excitatory and inhibitory tonotopic bands in chinchilla inferior colliculus revealed by c-fos immuno-labeling.we describe in detail a reliable experimental protocol for c-fos immuno-labeling of patterns of neural activation in the chinchilla (chinchilla laniger). we report on resting-level neural activity in inferior colliculus (ic) of auditory midbrain, and on tonotopic bands present following 90 min of pure-tone sound stimulation. neurons activated by 6-khz sound stimulation lay ventro-medial to those activated at 2 khz. this is consistent with the known tonotopic organization of ic, and verified in t ...201425158304
reproductive performance and weaning success in fur-chewing chinchillas (chinchilla lanigera).in captive chinchillas, one of the most challenging behavioral problems is the development of a stress-related abnormal repetitive behavior (arb) known as "fur-chewing". we investigated whether there is a relationship between the severity of fur-chewing behavior and reproductive function in male and female chinchillas. regardless of the severity of abnormal behavior, fur-chewing males did not show significant differences in seminal quality (sperm concentration, motility and viability; integrity ...201425152519
extrahepatic biliary tract in chinchilla (chinchilla laniger, molina).the aim of the study was the macromorphological analysis of extrahepatic biliary tract in chinchilla (chinchilla laniger molina). bile ducts, the gall bladder and portal vein were injected with coloured latex. using the technique of dissection, bile ducts were isolated from the liver lobes. it was found that the cystic duct in this species is rarely single. hepatic ducts form a system of multiple anastomosing structures running in the hepatoduodenal ligament. many bile duct openings were observe ...201525091180
parvovirus-derived endogenous viral elements in two south american rodent genomes.we describe endogenous viral elements (eves) derived from parvoviruses (family parvoviridae) in the genomes of the long-tailed chinchilla (chinchilla lanigera) and the degu (octodon degus). the novel eves include dependovirus-related elements and representatives of a clearly distinct parvovirus lineage that also has endogenous representatives in marsupial genomes. in the degu, one dependovirus-derived eve was found to carry an intact reading frame and was differentially expressed in vivo, with i ...201425078696
histology of the ovary of chinchilla lanigera in captivity.chinchilla, the lanigera variety in particular, is one of the most valuable rodents in the fur industry. the chinchilla ovary is morphologically similar to that of other south american hystricognath rodents, especially as regards its anatomy and, to a lesser degree, its histology. the presence of numerous primary follicles throughout the annual cycle suggests that a few of them are recruited to initiate growth and differentiation during folliculogenesis. primary follicles with two or more oocyte ...201424939708
disseminated mycobacterium genavense infection in a chinchilla (chinchilla lanigera).a 1-year-old neutered male chinchilla (chinchilla lanigera) was presented with emaciation and a 1-month history of progressive weight loss. the animal was bright and responsive on clinical examination, but had poor body condition. serum biochemical analysis revealed elevated alanine amino transferase and alkaline phosphatase. ultrasound examination was unremarkable. thoracic radiography showed changes consistent with bullous emphysema and severe pneumonia. antibiotic therapy was initiated, but t ...201424813153
isolation of a campylobacter lanienae-like bacterium from laboratory chinchillas (chinchilla laniger).routine necropsies of 27 asymptomatic juvenile chinchillas revealed a high prevalence of gastric ulcers with microscopic lymphoplasmacytic gastroenteritis and typhlocolitis. polymerase chain reaction (pcr) analysis using campylobacter genus-specific partial 16s rrna primers revealed the presence of campylobacter spp. dna in the faeces of 12 of 27 animals (44.4%). species-specific partial 16s rrna pcr and sequencing confirmed that these animals were colonized with campylobacter lanienae, a gram-n ...201424628887
ontogenetic allometry in the thoracolumbar spine of mammal species with differing gait use.vertebrae are serially homologous structures with tight integration through their evolution and development. however, in mammals, the thoracic and lumbar regions are morphologically and functionally differentiated. we test the hypothesis that locomotor specialization is associated with altered post-natal growth patterns in vertebrae from different vertebral regions. we use longitudinal data to examine thoracolumbar growth in two specialized half-bounding (oryctolagus cuniculus and chinchilla lan ...201424617990
seasonal evaluations of urinary androgen metabolites and semen quality in domestic long-tailed chinchilla (chinchilla lanigera) under natural photoperiod.chinchilla spp. is a south american hystricomorph rodent genus currently considered almost extinct in the wild. the high quality of chinchilla fur motivated the harvesting of chinchillas for the fur market. reproductive biology advances come from studies on commercially exploited animals, especially chinchilla lanigera. we studied seasonal variation of urinary androgen metabolites, sperm concentration and sperm functional activity in males of domestic chinchilla lanigera under natural photoperio ...201424503344
another one bites the dust: bite force and ecology in three caviomorph rodents (rodentia, hystricognathi).mammals have developed sophisticated strategies adapting to particular locomotor modes, feeding habits, and social interactions. many rodent species have acquired a fossorial, semi-fossorial, or even subterranean life-style, converging on morphological, anatomical, and ecological features but diverging in the final arrangement. these ecological variations partially depend on the functional morphology of their digging tools. muscular and mechanical features (e.g., lever arms relationship) of the ...201424482421
drinking preferences in chinchillas (chinchilla laniger), degus (octodon degu) and guinea pigs (cavia porcellus).chinchilla (chinchilla laniger), degus (octodon degus) and guinea pigs (cavia porcellus) are south american rodents living in a semi-arid habitat with varying, species-specific adaptations to water deprivation. nonetheless, several diseases have been linked to insufficient water intake when these species are kept as pets, such as urolithiasis or obstipation. this study evaluated preferences for drinking systems. six animals of each species were given a choice between an open dish and a nipple dr ...201424405017
enteric infection and subsequent septicemia due to attaching and effacing escherichia coli in a chinchilla.an adult male chinchilla (chinchilla lanigera) presented with severe lethargy and tachypnea; the physical examination was otherwise unremarkable. due to the animal's clinical condition, it was submitted for necropsy but died immediately prior to euthanasia. clinicopathologic findings included leukocytosis with a left-shift neutrophilia and lymphopenia, azotemia, hyperphosphatemia, hyperglycemia, hyperlipemia, electrolyte imbalance, cholestasis, and hepatocellular damage. neutrophilic enteritis w ...201324326226
organisation of autonomic nervous structures in the large intestine of chinchilla (chinchilla laniger molina).the organization of autonomic nerve structures in the large intestine of chinchilla was investigated using histochemical and immunocytochemical methods. the myenteric plexus formed network nodes of cholinergic neurocyte agglomerations connected with bundles of nerve fibres and localized between the circular and longitudinal layers of the smooth muscles. the highest density of myenteric plexus was observed in the rectum. the different densities of myenteric plexus in subsequent parts of the large ...201324279160
axonal recordings from medial superior olive neurons obtained from the lateral lemniscus of the chinchilla (chinchilla laniger).interaural time differences (itds) are a major cue for localizing low-frequency (<1.5 khz) sounds. sensitivity to this cue first occurs in the medial superior olive (mso), which is thought to perform a coincidence analysis on its monaural inputs. extracellular single-neuron recordings in mso are difficult to obtain because (1) mso action potentials are small and (2) a large field potential locked to the stimulus waveform hampers spike isolation. consequently, only a limited number of studies rep ...201324174683
generalized taenia crassiceps cysticercosis in a chinchilla (chinchilla lanigera).taenia crassiceps is a cestode parasite that uses carnivores as definitive hosts and rodents and rabbits as main intermediate hosts, but other animal species and humans may also get infected. one adult male chinchilla (chinchilla lanigera) from an animal shelter in switzerland presented widespread subcutaneous fluctuant swellings extended over the forehead, nose, face and thoracic regions with a progressive growth over 3 months. the thoracic swelling was surgically resected, and it consisted of ...201424126089
subgross and macroscopic investigation of the coeliac artery in the chinchilla (chinchilla lanigera).the knowledge of branching and variations of the coeliac artery is clinically important, especially in the surgical operations and non-surgical treatments.moreover, the chinchillas abdominal region have been used as a model in some surgical experimental researches. in this frame, we have aimed to explain the branching of this artery in the chinchillas detailedly. a total of 10 adult, healthy,male chinchillas (chinchilla lanigera) were used to investigate the origin and the course of the coeliac ...201324068688
morphology and immunohistochemical characteristics of the pterygopalatine ganglion in the chinchilla (chinchilla laniger, molina).histological and histochemical investigations revealed that the pterygopalatine ganglion (ppg) in the chinchilla is a structure closely connected with the maxillary nerve. macro-morphological observations disclosed two different forms of the ganglion: an elongated stripe representing single agglomeration of nerve cells, and a ganglionated plexus comprising smaller aggregations of neurocytes connected with nerve fibres. immunohistochemistry revealed that nearly 80% of neuronal cell bodies in ppg ...201323971205
organization of the innervation of the oesophagus and stomach in chinchilla (chinchilla laniger, molina).using the histochemical and histological techniques the morphology and topography of the autonomic plexuses of the oesophagus and stomach in chinchilla (chinchilla laniger) was investigated. ache-positive and adrenergic structures in the myenteric and submucosal plexus were observed. according to the results the cholinergic structures were formed by the different in shape network meshes, various size of the neurons agglomerations and nerve fibres. adrenergic fibres were found. density of these s ...201323907940
organisation of autonomic nervous structures in the small intestine of chinchilla (chinchilla laniger, molina).using histochemical, histological and immunocytochemical methods, organisation of the autonomic nerve structures in small intestine of chinchilla was investigated. myenteric plexus was localised between circular and longitudinal layers of the smooth muscles. forming network nodes, the small autonomic, cholinergic ganglia were linked with the bundles of nerve fibres. adrenergic structures were visible as specific varicose, rosary-like fibres forming bundles of parallel fibres connecting network n ...201423848953
parabacteroides chinchillae sp. nov., isolated from chinchilla (chincilla lanigera) faeces.strains of gram-stain-negative, anaerobic, rod-shaped bacteria were isolated from chinchilla (chinchilla lanigera) faeces, and strain st166(t) was investigated taxonomically. phylogenetic analyses of 16s rrna gene sequences revealed that strain st166(t) belonged to the genus parabacteroides. strain st166(t) formed a distinct line of descent, and the highest sequence similarity to st166(t) was found with parabacteroides merdae jcm 9497(t) (95.6%) and parabacteroides johnsonii jcm 13406(t) (95.0%) ...201323563230
sexual hormone fluctuation in chinchillas.the data about chinchilla (chinchilla laniger) reproduction are limited and in some cases discordant. the aim of this study was to monitor the sexual hormone fluctuation by fecal progesterone level and colpocytology analysis by vaginal smears in order to evaluate the different phases of the oestrus cycle. twenty-four non pregnant chinchillas aged from 1 to 4 years old and subdivided in three groups were monitored. in contrast with findings reported in other study, the high values of progesterone ...201323347544
evaluation of heart murmurs in chinchillas (chinchilla lanigera): 59 cases (1996-2009).to determine the prevalence of heart murmurs in chinchillas (chinchilla lanigera) and determine whether heart murmurs were associated with cardiac disease.201223113527
processing pitch in a nonhuman mammal (chinchilla laniger).whether the mechanisms giving rise to pitch reflect spectral or temporal processing has long been debated. generally, sounds having strong harmonic structures in their spectra have strong periodicities in their temporal structures. we found that when a wideband harmonic tone complex is passed through a noise vocoder, the resulting sound can have a harmonic structure with a large peak-to-valley ratio, but with little or no periodicity in the temporal structure. to test the role of harmonic struct ...201322985274
effect on sperm quality of different cryoprotectants in sperm of chinchilla lanigera.chinchilla lanigera is an endangered species therefore the development of cryopreservation protocols for its gametes is a useful tool in the application of assisted reproduction techniques. a study of the functionality of the spermatozoa punctured from the cauda epididymis was performed on fresh or frozen-thawed samples with three cryoprotective media (test-yolk buffer, sucrose and glycerol). the effect that these media had on sperm physiology during the freezing, storage and later thawing proce ...201322717073
infiltrative gastric adenocarcinoma in a chinchilla (chinchilla lanigera).a case of infiltrative gastric adenocarcinoma in a 5-year-old female chinchilla (chinchilla lanigera) is described. the animal died after a 5-day period of lethargy and anorexia. gross examination revealed increased gastric volume. the gastric wall was thickened and contained numerous firm, white nodules on the serosal surface. the lumen was obliterated by a firm mass and large amount of white, mucous secretion. numerous white, irregular plaques and nodules were observed on the mesentery, viscer ...201222621945
reproduction in chinchilla (chinchilla lanigera): current status of environmental control of gonadal activity and advances in reproductive techniques.a review of the biology of reproduction of chinchilla, focusing on environmental control of the gonadal activity, is presented. chinchilla is a south american hystricomorph rodent genus currently considered almost extinct in the wild. however, a domestic form is still widespread in breeding farms around the world. information regarding their reproductive biology has been obtained from studies on captive animals. in the case of chinchilla lanigera, a seasonal reproductive pattern has been frequen ...201222541170
adrenal activity and anxiety-like behavior in fur-chewing chinchillas (chinchilla lanigera).due to its complexity, in combination with a lack of scientific reports, fur-chewing became one of the most challenging behavioral problems common to captive chinchillas. in the last years, the hypothesis that fur-chewing is an abnormal repetitive behavior and that stress plays a role in its development and performance has arisen. here, we investigated whether a relationship existed between the expression and intensity of fur-chewing behavior, elevated urinary cortisol excretion and anxiety-rela ...201222504323
third-window vibroplasty with an active middle ear implant: assessment of physiologic responses in a model of stapes fixation in chinchilla lanigera.mechanical stimulation through a cochlear third window into the scala tympani in a chinchilla model with normal and fixed stapes can generate cochlear responses equivalent to acoustic stimuli.201222334156
the spinal nerves that constitute the lumbosacral plexus and their distribution in the chinchilla.in this study, the spinal nerves that constitute the lumbosacral plexus (plexus lumbosacrales) (lsp) and its distribution in chinchilla lanigera were investigated. ten chinchillas (6 males and 4 females) were used in this research. the spinal nerves that constitute the lsp were dissected and the distribution of pelvic limb nerves originating from the plexus was examined. the iliohypogastric nerve arose from l1 and l2, giving rise to the cranial and caudal nerves, and the ilioinguinal nerve arose ...201122332298
investigations on the conjunctival goblet cells and the characteristics of the glands associated with the eye in chinchillas (chinchilla laniger).to investigate the density and distribution of conjunctival goblet cells (gc) and study the anatomy and microscopic characteristics of glands associated with the eye in chinchillas (chinchilla laniger).201222288655
occurrence of giardia duodenalis infection in chinchillas (chincilla lanigera) from italian breeding facilities.the present work investigated the occurrence of giardia infection in chinchilla lanigera reared in three italian breeding facilities and determined their role as potential zoonotic reservoir. one hundred and four fecal samples were tested for the presence of giardia spp. cysts using a direct fluorescent assay (dfa). a high positivity rate (39.4%) was found despite all animals were asymptomatic at the time of sampling. thirty-one positive samples were genetically characterized by sequence analysi ...201222265218
Morphometric studies of Leydig cells in chinchillas (Chinchilla lanigera) during high and low fertility seasons.The aim of this study was to examine morphometric data of Leydig cells of 10 male chinchillas. Testes, cut into 5-microm thick sections, were stained using the p.a.S. and Masson's methods. Some 3800 Leydig cells have been evaluated. Their dimensions, as well as the diameters of their nuclei and the distances of the nuclei from the boundaries of the cells, have been measured. The areas of the surface and volumes of the nuclei of Leydig cells have been calculated, as well as the areas of the surfa ...201122195476
postnatal development of cochlear microphonic and compound action potentials in a precocious species, chinchilla lanigera.the development of sound-evoked responses in chinchilla lanigera was studied from postnatal ages p0-1 (first 24 h) to adult. cochlear microphonic (cms) and compound action potentials (caps), representing ensemble sound-evoked activities of hair cells and auditory nerve fibers, respectively, were present as early as age p0-1. the data indicate that cm thresholds and sensitivities were generally adult-like (i.e., fall into adult ranges) at birth, but suprathreshold cm amplitudes remained below adu ...201121786866
seminal quality and neutral alpha-glucosidase activity after sequential electroejaculation of chinchilla (ch. lanigera).the objectives of this study of seminal quality of chinchilla (chinchilla lanigera) males were to evaluate (1) the use of neutral alpha-glucosidase (nag) as a functional epididymal marker in this species, and (2) the effects of repetitive electroejaculation on sperm function and seminal nag concentration. semen was obtained by electroejaculation from sexually mature domestic ch. lanigera males (n=6) once a week for six consecutive weeks, and evaluated to assess seminal volume and nag activity, a ...201121782362
cystic endometrial hyperplasia and chronic endometritis in a chinchilla.case description-a 4-year-old nulliparous sexually intact female chinchilla (chinchilla lanigera) was evaluated because of a 2-month history of blood being sporadically observed in its cage. clinical findings-results of physical examination of the chinchilla were unremarkable except for the presence of blood-stained fur around the perineum. there were no external lesions to account for the bleeding. findings on urinalysis, bacteriologic culture of urine, and whole-body radiography were unremarka ...201121756180
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