Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| novel quantitative real-time pcr approach to determine safflower (carthamus tinctorius) adulteration in saffron (crocus sativus). | this work intended to develop dna-based methods to detect and quantify safflower as an adulterant in saffron. species-specific pcr and real-time pcr with evagreen dye targeting the its region of carthamus tinctorius l. (safflower) were successfully proposed. the assays allowed absolute and relative sensitivities of 2pg of safflower dna (∼1.4 dna copies) and 0.1% of safflower in saffron (crocus sativus l.), respectively. a normalised real-time pcr approach was also proposed in the range of 0.1-20 ... | 2017 | 28372231 |
| parameters influencing agrobacterium-mediated transformation system in safflower genotypes aks-207 and pkv pink. | shoot regeneration in safflower (carthamus tinctorius 'aks 207' and 'pkv pink') genetically transformed using agrobacterium was used for assessing various constraints to the efficiency of transformation including infection period, virulence induction medium, co-cultivation period, bacterial titre, selection regime, and the natural phenolic compound acetosyringone. transformation frequency was promising with 8-10-day-old cotyledonary leaf explants. therefore, explants of that age cultured on agro ... | 2016 | 28330253 |
| antioxidant activities of aqueous extracts from 12 chinese edible flowers in vitro and in vivo. | the antioxidant function of edible flowers have attracted increasing interest. however, information is lacking on the impact of edible flowers on oxidative injury including hypoxia-re-oxygenation and hyperlipidemia. the antioxidant activities of aqueous extracts from 12 chinese edible flowers were assessed in four different antioxidant models, including total antioxidant capacity (tac), oxygen radical absorbance capacity (orac), scavenging hydroxyl radical capacity (shrc) and scavenging superoxi ... | 2017 | 28326000 |
| molecular dynamics simulation integrating the inhibition kinetics of hydroxysafflor yellow a on α-glucosidase. | inhibition of α-glucosidase has attracted the attention of researchers due to its connection to type-2 diabetes. hydroxysafflor yellow a (hsya) extracted from carthamus tinctorius l. is a natural antioxidant used in traditional chinese medicine. in this study, the effect of hsya on α-glucosidase was evaluated using inhibitory kinetics based on the antioxidant properties of hsya and by performing computational simulation integration methods. hsya reversibly inhibited α-glucosidase in a competitiv ... | 2017 | 28264629 |
| an enhanced targeted identification strategy for the selective identification of flavonoid o-glycosides from carthamus tinctorius by integrating offline two-dimensional liquid chromatography/linear ion-trap-orbitrap mass spectrometry, high-resolution diagnostic product ions/neutral loss filtering and liquid chromatography-solid phase extraction-nuclear magnetic resonance. | targeted identification of potentially bioactive molecules from herbal medicines is often stymied by the insufficient chromatographic separation, ubiquitous matrix interference, and pervasive isomerism. an enhanced targeted identification strategy is presented and validated by the selective identification of flavonoid o-glycosides (fogs) from carthamus tinctorius. it consists of four steps: (i) enhanced separation and detection by offline two-dimensional liquid chromatography/ltq-orbitrap ms (of ... | 2017 | 28256254 |
| inhibition of cerebral ischemia/reperfusion injury-induced apoptosis: nicotiflorin and jak2/stat3 pathway. | nicotiflorin is a flavonoid extracted from carthamus tinctorius. previous studies have shown its cerebral protective effect, but the mechanism is undefined. in this study, we aimed to determine whether nicotiflorin protects against cerebral ischemia/reperfusion injury-induced apoptosis through the jak2/stat3 pathway. the cerebral ischemia/reperfusion injury model was established by middle cerebral artery occlusion/reperfusion. nicotiflorin (10 mg/kg) was administered by tail vein injection. cell ... | 2017 | 28250754 |
| evaluation of the sub-chronic toxicity of a standardized flavonoid extract of safflower in rats. | carthamus tinctorius l., or safflower, is an annual herbaceous crop belonging to the family asteraceae, which is cultivated throughout china and used as a traditional chinese medicine. our previous study revealed anti-parkinson's disease effects of an isolated standardized safflower flavonoid extract (safe). the purpose of this study is to evaluate the potential sub-chronic toxicity of safe. male and female sprague dawley rats received three doses of safe (100, 300, and 500 mg/kg) q.d. by gavage ... | 2017 | 28192173 |
| effect of unconventional oilseeds (safflower, poppy, hemp, camelina) on in vitro ruminal methane production and fermentation. | dietary supplementation with oilseeds can reduce methane emission in ruminants, but only a few common seeds have been tested so far. this study tested safflower (carthamus tinctorius), poppy (papaver somniferum), hemp (cannabis sativa), and camelina (camelina sativa) seeds in vitro using coconut (cocos nucifera) oil and linseed (linum usitatissimum) as positive controls. | 2017 | 28188639 |
| hydroxysafflor yellow a alleviates lipopolysaccharide-induced acute respiratory distress syndrome in mice. | hydroxysafflor yellow a (hsya) is an effective ingredient of the chinese herb carthamus tinctorius l. the present study investigated the protective effect of hsya on lipopolysaccharide (lps)-induced acute respiratory distress syndrome in mice, and the underlying mechanisms involved. hsya (14, 28, 56 mg/kg) was intraperitoneally injected to mice once daily from day 1 to 10 after lps administration. hsya attenuated the body weight loss, the augmented left index and the increase of pathologic chang ... | 2017 | 28154251 |
| luhong formula inhibits myocardial fibrosis in a paracrine manner by activating the gp130/jak2/stat3 pathway in cardiomyocytes. | luhong formula (lhf)-a traditional chinese medicine containing cervus nippon temminck, carthamus tinctorius l., cinnamomum cassia presl, codonopisis pilosula( franch.) nannf., astragalus membranaceus ( fisch.) bge. var. mongholicus ( bge.) hsiao, lepidium apetalum willd-is used in the treatment of heart failure. | 2017 | 28115285 |
| carthamus tinctorius l. ameliorates brain injury followed by cerebral ischemia-reperfusion in rats by antioxidative and anti-inflammatory mechanisms. | carthamus tinctorius l. (ct) or safflower is widely used in traditional chinese medicine. this study investigated the effects of ct extract (cte) on ischemia-reperfusion (i/r) brain injury and elucidated the underlying mechanism. | 2016 | 28096971 |
| hydroxysafflor yellow a cardioprotection in ischemia-reperfusion (i/r) injury mainly via akt/hexokinase ii independent of erk/gsk-3β pathway. | hydroxysafflor yellow a (hsya) is the main active component of carthamus tinctorius l which has been used for hundreds of years in chinese folk medicine in the treatment cardiovascular disease. this study was designed to investigate whether hsya exerts cardioprotection in ischemia-reperfusion (i/r) injury heart and the mechanisms involved. the protective effect and mechanisms in myocardial ischemia reperfusion injury of hsya was evaluated by hypoxia-recover (h/r) injury cell model which induced ... | 2017 | 28068632 |
| hydroxysafflor yellow a promotes angiogenesis via the angiopoietin 1/ tie-2 signaling pathway. | the flowers of carthamus tinctorius l. are widely used in traditional chinese medicine to treat cerebrovascular and cardiovascular diseases. hydroxysafflor yellow a (hsya), the main constituent of c. tinctorius l. flowers, is known for its multiple biological activities. the present study investigated the effects of hsya on angiogenesis in vitro and in a mouse hindlimb ischemia model. | 2016 | 27894114 |
| safflower (catharmus tinctorius l.) oil supplementation in overnourished rats during early neonatal development: effects on heart and liver function in the adult. | carthamus tinctorius l. (common name: safflower) is an herb whose extracted oil (safflower oil) has been employed in both alternative and conventional medicine in the treatment of disease. overnutrition during early postnatal life can increase the lifetime risk of obesity and metabolic syndrome. here we investigate the effect of safflower oil supplementation given during a critical early developmental stage on the eventual occurrence of metabolic disease in overnourished rats. groups of overnour ... | 2016 | 27863203 |
| comparative analysis of the effects of hydroxysafflor yellow a and anhydrosafflor yellow b in safflower series of herb pairs using prep-hplc and a selective knock-out approach. | the flower of carthamus tinctorius l. (carthami flos, safflower), important in traditional chinese medicine (tcm), is known for treating blood stasis, coronary heart disease, hypertension, and cerebrovascular disease in clinical and experimental studies. it is widely accepted that hydroxysafflor yellow a (hsya) and anhydrosafflor yellow b (asyb) are the major bioactive components of many formulae comprised of safflower. in this study, selective knock-out of target components such as hsya and asy ... | 2016 | 27827969 |
| utilization of molecular, phenotypic, and geographical diversity to develop compact composite core collection in the oilseed crop, safflower (carthamus tinctorius l.) through maximization strategy. | safflower (carthamus tinctorius l.) is a dryland oilseed crop yielding high quality edible oil. previous studies have described significant phenotypic variability in the crop and used geographical distribution and phenotypic trait values to develop core collections. however, the molecular diversity component was lacking in the earlier collections thereby limiting their utility in breeding programs. the present study evaluated the phenotypic variability for 12 agronomically important traits durin ... | 2016 | 27807441 |
| safflower yellow prevents pulmonary metastasis of breast cancer by inhibiting tumor cell invadopodia. | carthamus tinctorius l. is a traditional chinese medicine that activates blood circulation and dissipates blood stasis, and has been extensively used as antitumor treatment in a clinical setting in single or in compound preparation form. however, empirical evidence and a better understanding of the possible mechanisms involved are still required. here, we investigated the role of safflower yellow (sy), the active ingredient of c. tinctorius, in the pulmonary metastasis of breast cancer, and the ... | 2016 | 27776431 |
| effects of dietary administration of rose hip and safflower on growth performance, haematological, biochemical parameters and innate immune response of beluga, huso huso (linnaeus, 1758). | the aim of this study was to investigate effects of two dietary medicinal herbs, rose hip (rosa canina) and safflower (carthamus tinctorius) supplementation on growth performance, haematological, biochemical parameters and innate immune response of in juvenile beluga, huso huso. fish (26.3 ± 0.4 g) were allocated into 15 tanks (20 fish per tank) and triplicate groups were fed a control diet or diets containing 1% and 2% of medicinal herbs, respectively. feed conversion ratio (fcr), specific grow ... | 2016 | 27773731 |
| in vitro study on anti-hepatitis c virus activity of spatholobus suberectus dunn. | hepatitis c virus (hcv) infects 200 million people worldwide, and 75% of hcv cases progress into chronic infections, which consequently cause cirrhosis and hepatocellular carcinoma. hcv infection is treated with currently considered standard drugs, including direct anti-viral agents (daas), alone or in combination with peginterferon-α plus ribavirin. however, sustained viral responses vary in different cohorts, and high costs limit the broad use of daas. in this study, the ethanol and water extr ... | 2016 | 27754461 |
| carthorquinosides a and b, quinochalcone c-glycosides with diverse dimeric skeletons from carthamus tinctorius. | two novel quinochalcone c-glycosides, carthorquinosides a (1) and b (2), were isolated from the florets of carthamus tinctorius. their structures, including the absolute configurations, were established by analysis of nmr and ms data, together with chemical degradation and electronic circular dichroism spectra. compound 1 has an unprecedented quinochalcone-flavonol structure linked via a methylene bridge, and compound 2 comprises two glucopyranosylquinochalcone moieties linked via the formyl car ... | 2016 | 27748595 |
| hydroxysafflor yellow a alleviates myocardial ischemia/reperfusion in hyperlipidemic animals through the suppression of tlr4 signaling. | hyperlipidemia aggravates myocardial ischemia/reperfusion (mi/r) injury through stimulating excessive inflammatory response. therefore, blockade of inflammatory signal is a potential therapeutic management for mi/r complicated with hyperlipidemia. hydroxysafflor yellow a (hsya, a monomer extracted from carthamus tinctorius l.), was studied in this article to address that the regulation of inflammatory signal would alleviate mi/r combined with hyperlipidemia injury. high-fat diet induced hyperlip ... | 2016 | 27731393 |
| volatile oxidation compounds and stability of safflower, sesame and canola cold-pressed oils as affected by thermal and microwave treatments. | the goal of this study was to investigate the effect of heating and microwave treatment on the levels of volatile oxidation products and the stability of safflower (carthamus tinctorius l.), sesame (sesamum indicum) and canola (brassica napus l.) cold-pressed oils. cold-pressed oils were subjected to conventional heating (oven test) using air-forced oven at 60°c and microwave heating for 2 and 4 min. the changes in conjugated diene (cd) and conjugated triene (ct) values were monitored during tre ... | 2016 | 27725480 |
| hydroxysafflor yellow a exerts antioxidant effects in a rat model of traumatic brain injury. | free radical-induced oxidative damage occurs rapidly and is of primary importance during the secondary pathophysiological cascades of traumatic brain injury (tbi). hydroxysafflor yellow a (hsya) is a constituent of the flower petals of carthamus tinctorius (safflower) and may represent a potential therapeutic strategy to improve outcomes following tbi. the present study aimed to identify hsya in the brain tissues of rats exposed to tbi to determine its absorption and to investigate the underlyin ... | 2016 | 27599591 |
| neuroprotective effects of a standardized flavonoid extract from safflower against a rotenone-induced rat model of parkinson's disease. | parkinson's disease (pd) is a major age-related neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra par compacta (snpc). rotenone is a neurotoxin that is routinely used to model pd to aid in understanding the mechanisms of neuronal death. safflower (carthamus tinctorius. l.) has long been used to treat cerebrovascular diseases in china. this plant contains flavonoids, which have been reported to be effective in models of neurodegenerative disease. ... | 2016 | 27563865 |
| first record of euphoria lurida fabricius (coleoptera: scarabaeidae) injurious to safflower (carthamus tinctorius l.) (asterales: asteraceae) in brazil. | we present the first report on euphoria lurida (fabricius) (coleoptera: scarabaeidae) infestation on safflower (carthamus tinctorius l.), a crop of industrial and medicinal importance. between september and october 2013-2015 in paraná state, we observed e. lurida adults feeding on safflower plants from the inception of flower head formation onwards, over an area of approximately 400 m(2). losses in the productivity of infested plants were estimated between 15 and 50%. the damage was characterize ... | 2017 | 27553719 |
| cloning and functional analysis of three chalcone synthases from the flowers of safflowers carthamus tinctorius. | the flowers of safflowers (carthamus tinctorius l.) are very important as they are the sole source of their distinct pigments, i.e. carthamus-red and -yellows, and have historically had strong connections to the cultural side of human activities such as natural dyes, rouge, and traditional medicines. the distinct pigments are quinochalcone c-glucosides, which are found specifically in the flowers of c. tinctorius. to investigate the biosynthetic pathways of quinochalcone c-glucosides, de novo as ... | 2016 | 27534116 |
| hydroxysafflor yellow a inhibits tgf-β1-induced activation of human fetal lung fibroblasts in vitro. | hydroxysafflor yellow a (hsya) is one of the chemical component isolated from chinese medicine carthamus tinctorius l. our preliminary study confirmed that hsya attenuated bleomycin-induced pulmonary fibrosis in mice. in this study, we evaluated the effect of hsya on tgf-β1-induced activation of human fetal lung fibroblasts (mrc-5) and explored the underlying mechanisms of its activity. | 2016 | 27457091 |
| superoxide-scavenging and tyrosinase-inhibitory activities of the extracts of some chinese medicines. | the superoxide-scavenging and the tyrosinase-inhibitory activities of 28 kinds of plants used as chinese medicines were evaluated. methanol/water extracts were used for the screening tests, and for those which represented high activities, other kinds of extracts were also studied. the extracts of mallotus japonicus muell. arg. scavenged superoxide strongly; the half-inhibiting concentration (ic50) of its 50% methanol/water extract was 10.57 μg of dried material in 1 ml of reaction mixture. the e ... | 1997 | 27396888 |
| expression patterns of three ugt genes in different chemotype safflower lines and under meja stimulus revealed their potential role in flavonoid biosynthesis. | safflower (carthamus tinctorius l.) has received a significant amount of attention as a medicinal plant in china. flavonoids are the dominant active medical compounds. udp-glycosyltransferase plays an essential role in the biosynthesis and storage of flavonoids in safflower. in this study, 45 ugt unigenes were screened from our transcriptomic database of safflower. among them, 27 ugt unigenes were predicted to own a complete open reading frame with various pi and mw. the phylogenetic tree showed ... | 2016 | 27391785 |
| rapid fingerprint analysis of flos carthami by ultra-performance liquid chromatography and similarity evaluation. | flos carthami (fc), the dried flower of carthamus tinctorius l., has widely been used for the treatment of cardiovascular diseases in china. a rapid fingerprint analysis method of fc was established by ultra-performance liquid chromatography (uplc) for the quality control. the analysis time was shortened by 45 min, from 75 min on conventional high-performance liquid chromatography (hplc) to 30 min on uplc. ten batches of fc samples from various sources were analyzed by the uplc method. coexistin ... | 2016 | 27377888 |
| radionuclides: accumulation and transport in plants. | application of radioactive elements or radionuclides for anthropogenic use is a widespread phenomenon nowadays. radionuclides undergo radioactive decays releasing ionizing radiation like gamma ray(s) and/or alpha or beta particles that can displace electrons in the living matter (like in dna) and disturb its function. radionuclides are highly hazardous pollutants of considerable impact on the environment, food chain and human health. cleaning up of the contaminated environment through plants is ... | 2017 | 27300012 |
| effects of extracts and isolated compounds from safflower on some index of promoting blood circulation and regulating menstruation. | carthamus tinctorius is used as one of the traditional chinese medicine (tcm) materials in prescriptions and composite to promote blood circulation to remove blood stasis, regulate menstruation and alleviate pain for over 2500 years. modern pharmacological experiments have demonstrated that safflower has wide-reaching biological activities, including dilating coronary artery, modulating immune system, improving myocardial ischemia, anticoagulation and thromboprophylaxis, antioxidation, antihypox ... | 2016 | 27286914 |
| molecular characterization of flavanone 3-hydroxylase gene and flavonoid accumulation in two chemotyped safflower lines in response to methyl jasmonate stimulation. | among secondary metabolites, flavonoids are particularly crucial for plant growth, development, and reproduction, as well as beneficial for maintenance of human health. as a flowering plant, safflower has synthesized a striking variety of flavonoids with various pharmacologic properties. however, far less research has been carried out on the genes involved in the biosynthetic pathways that generate these amazing flavonoids, especially characterized quinochalcones. in this study, we first cloned ... | 2016 | 27286810 |
| the mechanism by which safflower yellow decreases body fat mass and improves insulin sensitivity in hfd-induced obese mice. | safflower yellow (sy) is the main effective ingredient of carthamus tinctorius l. it has been reported that sy plays an important role in anti-inflammation, anti-platelet aggregation, and inhibiting thrombus formation. in present study, we try to investigate the effects of sy on body weight, body fat mass, insulin sensitivity in high fat diet (hfd)-induced obese mice. | 2016 | 27242533 |
| genetic mapping of millions of snps in safflower (carthamus tinctorius l.) via whole-genome resequencing. | accurate assembly of complete genomes is facilitated by very high density genetic maps. we performed low-coverage, whole-genome shotgun sequencing on 96 f6 recombinant inbred lines (rils) of a cross between safflower (carthamus tinctorius l.) and its wild progenitor (c. palaestinus eig). we also produced a draft genome assembly of c. tinctorius covering 866 million bp (∼two-thirds) of the expected 1.35 gbp genome after sequencing a single, short insert library to ∼21 × depth. sequence reads from ... | 2016 | 27226165 |
| production and characterisation of reduced-fat and pufa-enriched burrata cheese. | burrata is an italian fresh 'pasta filata' cheese made from cow's milk and cream that is rapidly spreading in europe. it has very high caloric content, and a technological protocol was developed for producing a reduced-fat type and fortifying it with polyunsaturated fatty acids (pufa) of vegetable origin. a satisfactory reduced-fat prototype was obtained by using a 14% fat cream, which was specifically developed by diluting double cream with a suspension of carob seed flour. the composition of t ... | 2016 | 27210495 |
| in vitro evaluation of excess copper affecting seedlings and their biochemical characteristics in carthamus tinctorius l. (variety pbns-12). | the present study was focused to recognize the changes in the safflower (carthamus tinctorius l. variety pbns-12), when exposed to different concentration of copper (25, 50 and 100 μm) along with control (0.5 μm) for 10 and 20 days. this experiment used hoagland's nutrient solution to meet the external nutrient conditions, which includes micro and macronutrients equivalent to soil solution with copper sulphate (cuso4. 5h2o) as a metal stress. the plant samples were harvested after 10 and 20 days ... | 2016 | 27186026 |
| synergistic cardioprotective effects of danshensu and hydroxysafflor yellow a against myocardial ischemia-reperfusion injury are mediated through the akt/nrf2/ho-1 pathway. | in clinical practice, the traditional chinese medicinal herbs, radix salvia miltiorrhiza and carthamus tinctorius l., are usually prescribed in combination due to their significant cardioprotective effects. however, the mechanisms responsible for these combined effects remain unknown. thus, in this study, we investigated the mechanisms responsible for the combined effects of danshensu (dss) and hydroxysafflor yellow a (hsya) by establishing a rat model of myocardial ischemia/reperfusion (mi/r), ... | 2016 | 27176815 |
| the mixture of salvia miltiorrhiza-carthamus tinctorius (danhong injection) alleviates low-dose aspirin induced gastric mucosal damage in rats. | danhong injection (dhi) is quite often used in combination with low-dose aspirin (asa, 75-325mg daily) in clinic, particularly for the treatment of cardiovascular diseases. exploring their interaction profile is of great clinical importance. | 2016 | 27161407 |
| antioxidant effects of hydroxysafflor yellow a and acetyl-11-keto-β-boswellic acid in combination on isoproterenol-induced myocardial injury in rats. | oxidative stress plays an important role in the initiation and development of myocardial injury (mi). the peroxisome proliferator-activated receptor gamma coactivator-1α (pgc‑1α)/nuclear factor erythroid 2-related factor 2 (nrf2) pathway is considered to be a potential target for cardioprotection in mi. acetyl-11-keto-β-boswellic acid (akba) is the major organic acid component extracted from boswellia serrata roxb. ex colebr. hydroxysafflor yellow a (hsya) is the principal active constituent of c ... | 2016 | 27121241 |
| attenuation of the lps-induced, erk-mediated upregulation of fibrosis-related factors fgf-2, upa, mmp-2, and mmp-9 by carthamus tinctorius l in cardiomyoblasts. | severe and potentially fatal hypotension and cardiac contractile dysfunction are common symptoms in patients with sepsis. lps was previously found to dramatically upregulate expression of fibrosis-related factors fgf-2, upa, mmp-2, and mmp-9 in primary cardiac fibroblasts. mmps are capable of denaturing and degrading fibrillar collagens and other components of the extracellular matrix (ecm). studies have shown that dysregulation of expression of mmps is associated with development of myocardial ... | 2017 | 27098997 |
| phytochemistry and pharmacology of carthamus tinctorius l. | carthamus tinctorius l. is a multifunctional cash crop. its flowers and seeds are extensively used in traditional herbal medicine in china, korea, japan, and other asian countries, for treating various ailments such as gynecological, cardiovascular, and cerebrovascular diseases as well as blood stasis and osteoporosis. more than 100 compounds have been isolated and identified from c. tinctorius. flavonoids and alkaloids, especially the quinochalcone c-glycoside hydroxysafflor yellow a, n-(p-coum ... | 2016 | 27080938 |
| hydroxysafflor yellow a protects neurons from excitotoxic death through inhibition of nmdars. | excessive glutamate release causes overactivation of n-methyld-aspartate receptors (nmdars), leading to excitatory neuronal damage in cerebral ischemia. hydroxysafflor yellow a (hsya), a compound extracted from carthamus tinctorius l., has been reported to exert a neuroprotective effect in many pathological conditions, including brain ischemia. however, the underlying mechanism of hsya's effect on neurons remains elusive. in the present study, we conducted experiments using patch-clamp recording ... | 2017 | 27067428 |
| hydroxysafflor yellow a (hsya) attenuates hypoxic pulmonary arterial remodelling and reverses right ventricular hypertrophy in rats. | carthamus tinctorius l. is a traditional herbal medicine native to china with properties of promoting blood circulation and removing blood stasis, which is used for the treatment of cerebrovascular and cardiovascular diseases. hydroxysafflor yellow a (hsya) is the main constituent isolated from the flower of carthamus tinctorius l. which is used as a marker substance in the quality control of carthamus tinctorius l. in chinese pharmacopeia. | 2016 | 27063983 |
| intraspecific variability of carbon isotope discrimination and its correlation with grain yield in safflower: prospects for selection in a mediterranean climate. | the goals of the present study were to obtain a first estimate of intraspecific variability of carbon isotope discrimination (δ) in safflower, a thistle-like herbaceous plant, and to determine the statistical relationship between δ and grain yield as well as its components in a collection of 45 accessions of different origins. grain yield and aboveground biomass, harvest index, average grain weight, and δ (measured on the bulk leaf organic matter) were investigated in experimental field conditio ... | 2016 | 26982084 |
| genetic and epigenetic approaches for the possible detection of adulteration and auto-adulteration in saffron (crocus sativus l.) spice. | saffron (crocus sativus l.) is very expensive and, because of this, often subject to adulteration. modern genetic fingerprinting techniques are an alternative low cost technology to the existing chemical techniques, which are used to control the purity of food products. buddleja officinalis maxim, gardenia jasminoides ellis, curcuma longa l., carthamus tinctorius l. and calendula officinalis l. are among the most frequently-used adulterants in saffron spice. three commercial kits were compared c ... | 2016 | 26978342 |
| danhong injection attenuates isoproterenol-induced cardiac hypertrophy by regulating p38 and nf-κb pathway. | danhong injection (dhi), derived from rhizoma salviae miltiorrhizae (salvia miltiorrhiza bge., labiatae, danshen in chinese) and flos carthami (carthamus tinctorius l., compositae, salvia militiorrhiza bunge), is an extensively-used chinese material standardized clinical product for treatment of cardiovascular diseases. | 2016 | 26970569 |
| synergistic antihypertensive effect of carthamus tinctorius l. extract and captopril in l-name-induced hypertensive rats via restoration of enos and at₁r expression. | this study examined the effect of carthamus tinctorius (ct) extract plus captopril treatment on blood pressure, vascular function, nitric oxide (no) bioavailability, oxidative stress and renin-angiotensin system (ras) in n(ω)-nitro-l-arginine methyl ester (l-name)-induced hypertension. rats were treated with l-name (40 mg/kg/day) for five weeks and given ct extract (75 or 150 or 300 or 500 mg/kg/day): captopril (5 mg/kg/day) or ct extract (300 mg/kg/day) plus captopril (5 mg/kg/day) for two cons ... | 2016 | 26938552 |
| metabolic profile of anhydrosafflor yellow b in rats by ultra-fast liquid chromatography/quadrupole time-of-flight mass spectrometry. | anhydrosafflor yellow b (ahsyb) is one of the major active water-soluble pigments from carthamus tinctorius, which has been found to inhibit adp-induced platelet aggregation and possess significant antioxidant activity. however, the metabolic fate of ahsyb in vivo remains unknown. in order to explore whether ahsyb is extensively metabolized, the metabolites of ahsyb in plasma, urine, bile, and feces samples after intravenous administration to the rats were investigated by ultra-fast liquid chrom ... | 2016 | 26871281 |
| insight of saffron proteome by gel-electrophoresis. | saffron is a spice comprised of the dried stigmas and styles of crocus sativus l. flowers and, since it is very expensive, it is frequently adulterated. so far, proteomic tools have never been applied to characterize the proteome of saffron or identify possible cases of fraud. in this study, 1d-gel electrophoresis was carried out to characterize the protein profile of (i) fresh stigmas and styles of the plant; (ii) dried stigmas and styles from different geographical origins (spanish, italian, g ... | 2016 | 26840283 |
| uflc-q-tof/ms based screening and identification of the metabolites in plasma, bile, urine and feces of normal and blood stasis rats after oral administration of hydroxysafflor yellow a. | the dried flower of carthamus tinctorius l. (honghua) is a widely used traditional chinese medicine in clinics to treat coronary heart disease, hypertension, and cerebrovascular disease due to its functions of ameliorating circulation and removing blood stasis. hydroxysafflor yellow a (hsya) is an active marker component of honghua. in this paper, ultra-flow liquid chromatography coupled with quadrupole-time-of-flight mass-spectrometry (uflc-q-tof/ms) was established and successfully applied to ... | 2016 | 26827279 |
| hydroxysafflor yellow a attenuates bleomycin-induced pulmonary fibrosis in mice. | hydroxysafflor yellow a (hsya) is an active component of carthamus tinctorius l., and we want to investigate whether hsya attenuates pulmonary fibrosis induced by bleomycin (blm) in mice. the mice received a blm via oropharyngeal aspiration, and hsya was intraperitoneally injected. arterial blood gas analysis was performed. morphological changes and hydroxyproline content were measured. mrna expression of transforming growth factor-β1 (tgf-β1), connective tissue growth factor, α-smooth muscle ac ... | 2016 | 26777519 |
| evaluation of the effects of active fractions of chinese medicine formulas on il-1β, il-6, and tnf-α release from ana-1 murine macrophages. | yaotongning (ytn) is a traditional chinese medicine (tcm) that contains ten component medicinal materials (cmms) and uses chinese rice wine as a vehicle to enhance its efficacy. ytn has been used for rheumatoid arthritis (ra) treatment in china for decades and has been reported to have anti-inflammatory and analgesic effects, as well as to strengthen the immune system. | 2016 | 26732631 |
| expression of atp synthase cf1 alpha subunit gene (ctl-spn) as screened by the cdna-srap approach is correlated with spininess in carthamus tinctorius l. | the safflower floret is a traditional chinese medicine used to promote blood circulation and remove obstruction in the channels. the spines on its bracts are considered a handicap when manual harvest is involved. in this study, cdna-srap was used to systematically investigate which genes are associated with the spines. sixty pairs of possible primer combinations were used on two cdna pools representing spininess and spinelessness. six transcript-derived fragments were identified, of which two wi ... | 2015 | 26669008 |
| metabolomics reveals hippocampal metabolic fluctuations of postoperative fatigue syndrome and anti-fatigue effect of carthamus tinctorius l extract in rat model. | postoperative fatigue syndrome (pofs) is a common clinical complication followed by almost every major abdominal surgery. there is not a full explanation to the etiology of pofs, especially its central mechanism. carthamus tinctorius l is a classic traditional chinese medicine (tcm) which could exert the anti-fatigue effect on pofs. however, its mechanism is still lacking. here, ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (uhplc-q-tofms) ... | 2015 | 26577245 |
| de novo sequencing and analysis of the safflower transcriptome to discover putative genes associated with safflor yellow in carthamus tinctorius l. | safflower (carthamus tinctorius l.), an important traditional chinese medicine, is cultured widely for its pharmacological effects, but little is known regarding the genes related to the metabolic regulation of the safflower's yellow pigment. to investigate genes related to safflor yellow biosynthesis, 454 pyrosequencing of flower rna at different developmental stages was performed, generating large databases.in this study, we analyzed 454 sequencing data from different flowering stages in saffl ... | 2015 | 26516840 |
| selective ion monitoring of quinochalcone c-glycoside markers for the simultaneous identification of carthamus tinctorius l. in eleven chinese patent medicines by uhplc/qtof ms. | current china pharmacopoeia standards for the chinese patent medicines (cpms) that contain one or several the same drug(s) employ case-dependent tlc or hplc approaches to achieve qualitative identification. a qualitative "monomethod-heterotrait matrix" (mhm) strategy is thus proposed, by selective monitoring of multi-biomarkers, to achieve the identification of different cpms. carthamus tinctorius l. (safflower) is a reputable gynecological herbal medicine containing characteristic quinochalcone ... | 2016 | 26476296 |
| identification and evaluation of reference genes for accurate transcription normalization in safflower under different experimental conditions. | safflower (carthamus tinctorius l.) has received a significant amount of attention as a medicinal plant and oilseed crop. gene expression studies provide a theoretical molecular biology foundation for improving new traits and developing new cultivars. real-time quantitative pcr (rt-qpcr) has become a crucial approach for gene expression analysis. in addition, appropriate reference genes (rgs) are essential for accurate and rapid relative quantification analysis of gene expression. in this study, ... | 2015 | 26457898 |
| a case study on the genetic origin of the high oleic acid trait through fad2-1 dna sequence variation in safflower (carthamus tinctorius l.). | the safflower (carthamus tinctorius l.) is considered a strongly domesticated species with a long history of cultivation. the hybridization of safflower with its wild relatives has played an important role in the evolution of cultivars and is of particular interest with regards to their production of high quality edible oils. original safflower varieties were all rich in linoleic acid, while varieties rich in oleic acid have risen to prominence in recent decades. the high oleic acid trait is con ... | 2015 | 26442008 |
| effect of drought on safflower natural dyes and their biological activities. | drought is the main abiotic constraint that affects crop species behaviour regarding bio-chemical responses. the current study was conducted to examine the effect of water deficit on growth, phenolic and carotenoid contents as well as the antioxidant and antimicrobial activities of two carthamus tinctorius varieties (jawhara and 104) flowers. hence, plants were treated with different levels of water deficit: control (100 %), moderate water deficit (50 %) and severe water deficit (25 %). obtained ... | 2014 | 26417239 |
| development and validation of a uflc-ms/ms method for the determination of anhydrosafflor yellow b in rat plasma and its application to pharmacokinetic study. | a sensitive ultrafast liquid chromatography coupled with triple quadrupole mass spectrometric (uflc-ms/ms) method for the quantification of anhydrosafflor yellow b (ahsyb), a major active water-soluble pigment from carthamus tinctorius, in rat plasma has been developed and validated. sample preparation was achieved by protein precipitation of plasma with four volumes of methanol. rutin was used as the internal standard (is). the analytes were separated using a c18 column with an 8min gradient el ... | 2015 | 26409263 |
| duration of emission of volatile organic compounds from mechanically damaged plant leaves. | classical biological control of invasive alien weeds depends on the use of arthropod herbivores that are sufficiently host specific to avoid risk of injuring nontarget plants. host plant specificity is usually evaluated by using a combination of behavioral and developmental experiments under choice, no-choice and field conditions. secondary plant compounds are likely to have an important influence on host plant specificity. however, relatively little is known about the volatile organic compounds ... | 2015 | 26398629 |
| expression of bioactive recombinant human fibroblast growth factor 10 in carthamus tinctorius l. seeds. | fibroblast growth factor 10 (fgf10) is a member of the fgf superfamily. it exhibits diverse biological functions, and is extensively used for fundamental research and clinical applications involving hair growth, tissue repair, and burn wounds. oil bodies, obtained from oil seeds, have been exploited for a variety of biotechnology applications. the use of oil bodies reduces purification steps and costs associated with the production of heterogonous proteins. here, recombinant human fgf10 (rhfgf10 ... | 2015 | 26384708 |
| danhong injection protects cardiomyocytes against hypoxia/reoxygenation- and h2o2-induced injury by inhibiting mitochondrial permeability transition pore opening. | danhong injection (dhi), a chinese medical product extracted from radix et rhizoma salviae miltiorrhizae (salvia miltiorrhiza bge., labiatae, danshen in chinese) and flos carthami (carthamus tinctorius l., compositae, honghua in chinese), has been widely used for the treatment of ischemic heart disease, and clinical and experimental studies have demonstrated the protective effects against myocardial ischemia/reperfusion injury. nevertheless, the underlying cellular mechanisms responsible for thi ... | 2015 | 26320687 |
| protective effect of salvia miltiorrhiza and carthamus tinctorius extract against lipopolysaccharide-induced liver injury. | to investigate the hepatoprotective effects and mechanisms of an extract of salvia miltiorrhiza and carthamus tinctorius in vivo. | 2015 | 26290634 |
| development of genomic microsatellite markers in carthamus tinctorius l. (safflower) using next generation sequencing and assessment of their cross-species transferability and utility for diversity analysis. | safflower (carthamus tinctorius l.), an asteraceae member, yields high quality edible oil rich in unsaturated fatty acids and is resilient to dry conditions. the crop holds tremendous potential for improvement through concerted molecular breeding programs due to the availability of significant genetic and phenotypic diversity. genomic resources that could facilitate such breeding programs remain largely underdeveloped in the crop. the present study was initiated to develop a large set of novel m ... | 2015 | 26287743 |
| toxic potentials of ten herbs commonly used for aphrodisiac effect in turkey. | sexual dysfunction is a serious problem worldwide. in turkey, herbal products are used by some people suffering from sexual dysfunction. despite their therapeutic advantages, some constituents of herbs are potentially toxic and pose health risks because they can be bought from the market without a prescription. therefore, we aimed to determine the safety of herbs possessing aphrodisiac effects, chosen on the basis of their frequency of medicinal use and commercial importance in turkey. | 2015 | 26281312 |
| a new flavonol glycoside from the florets of carthamus tinctorius l. | one new flavonol glycoside, 6-hydroxykaempferol-3-o-β-d-glucoside-7-o-β-d-glucuronide (1), together with eight known flavonoids and three known quinochalcones, was isolated from the florets of carthamus tinctorius l. their structures were determined by extensive spectroscopic analyses. their cardioprotective effects against h2o2-induced apoptosis in h9c2 cells were also evaluated; compounds 1, 2, 4-5, 7-10 and 12 provided significant protective effects on h2o2-induced h9c2 cells at the concentra ... | 2016 | 26185946 |
| [full-length cdna cloning of flavonol synthase genes of carthamus tinctorius and construction plant expression vector]. | flavonol synthase (fls) is one of the key enzymes in flavonoids metabolic pathways. in this study, middle sequence was obtained from carthamus tinctorius transcriptome sequencing results. full-length cdnas of fls was cloned from petals of c. tinctorius to fls by using rt-pcr and race technology. its full-length cdna was 1,201 bp, with an open reading frame of 1,101 bp and 336 encoded amino acids. the phylogenetic analysis showed that, fls gene encoded amino acids in c. tinctorius were highly hom ... | 2015 | 26137682 |
| effect of shenkang granules on the progression of chronic renal failure in 5/6 nephrectomized rats. | shenkang granules (skgs) are a chinese herbal medicinal formula, consisting of rhubarb (rheum palmatum l.), salvia miltiorrhiza, milkvetch root [astragalus membranaceus (fisch.) bunge] and safflower (carthamus tinctorius l.). the aim of the present study was to investigate the effect of skg on chronic renal failure (crf) in 5/6 nephrectomized (5/6 nx) rats. the rats were randomly divided into seven groups (n=10 per group) as follows: (i) 5/6 nx (model group; 2.25 ml/kg/day normal saline); (ii) s ... | 2015 | 26136932 |
| [study on action mechanism of danhong injection based on computational system biology approach]. | danhong injection is a compound preparation of traditional chinese medicine salvia miltiorrhiza and carthamus tinctorius, and has been widely applied in treating coronary heart diseases and ischemic encephalopathy in clinic. despite the complexity of its chemical compounds and the diversity of targets, especially in system biology, there have not a report for its action mechanism as a whole regulatory biological network. in this study, protein data of s. miltiorrhiza and c. tinctorius were searc ... | 2015 | 26084184 |
| spectrophotometric determination of total serotonin derivatives in the safflower seeds with ehrlich's reagent and the underlying color reaction mechanism. | a new spectrophotometric method for the determination of total serotonin derivatives in the safflower (carthamus tinctorius l.) seeds is described. the determination is based upon a color reaction between serotonin derivatives and p-dimethylaminobenzaldehyde (ehrlich's reagent), which follows the electrophilic substitution reaction mechanism at the indole ring. the main factors affecting correct measurement of total serotonin derivatives concentration were studied. the maximum absorption wavelen ... | 2008 | 26059161 |
| hydroxysafflor yellow a attenuate lipopolysaccharide-induced endothelium inflammatory injury. | this study observed attenuating effect of hydroxysafflor yellow a (hsya), an effective ingredient of aqueous extract of carthamus tinctorius l, on lipopolysaccharide (lps)-induced endothelium inflammatory injury. | 2016 | 26015073 |
| short communication-evaluation of antianxiety and antidepressant properties of carthamus tinctorius l. (safflower) petal extract. | nowadays anxiety and depression are most commonly encountered diseases. they are not only difficult to diagnose but even difficult to treat since both are sometimes seen together or one predisposes the other. apart from this side effect profile of these drugs is also high; hence there is immense scope for the herbal drugs to treat these disorders. present study was therefore performed to evaluate the antianxiety and antidepressant effect of carthamus tinctorius petal extract. 28 white albino rat ... | 2015 | 26004733 |
| the complete chloroplast genome sequence of safflower (carthamus tinctorius l.). | safflower (carthamus tinctorius l.) is a traditional medical plants of asia. in this study, the complete chloroplast genome of safflower was presented. the total genome size was 153,675 bp in length, containing a pair of inverted repeats (irs) of 25,407 bp, separated by large single copy (lsc) and small single copy (ssc) of 83,606 bp and 19,156 bp, respectively. overall gc content of the genome was 37.4%. the chloroplast genome harbored 127 annotated genes, including 89 protein coding genes, 30 ... | 2016 | 25740214 |
| serum containing tongqiaohuoxue decoction suppresses glutamate-induced pc12 cell injury. | glutamate application is an established method of inducing pc12 cell injury. pc12 cells were cultured with serum containing tongqiaohuoxue decoction consisting of moschus, carthamus tinctorius, rhizoma chuanxiong, semen pruni persicae, and radix paeoniae rubra. after 24 hours of co-cultivation, glutamate (12.5 mm) was added to the culture medium. we found that serum containing tongqiaohuoxue decoction prevented the increase in reactive oxygen species, and the decreases in superoxide dismutase an ... | 2012 | 25722704 |
| hydroxysafflor yellow a inhibits angiogenesis of hepatocellular carcinoma via blocking erk/mapk and nf-κb signaling pathway in h22 tumor-bearing mice. | hydroxysafflor yellow a (hsya), a flavonoid derived and isolated from traditional chinese medicine carthamus tinctorius l., possesses anti-tumor activity. however, its effects on hepatocellular carcinoma (hcc) have not been investigated. the proliferation and metastasis of hcc are dependent on angiogenesis, which also strongly links with several signal transduction pathways associated with cell proliferation and apoptosis. this study aimed to explore the effect of hsya on vasculogenesis and to d ... | 2015 | 25720342 |
| matrix solid-phase dispersion extraction followed by high performance liquid chromatography-diode array detection and ultra performance liquid chromatography-quadrupole-time of flight-mass spectrometer method for the determination of the main compounds from carthamus tinctorius l. (hong-hua). | a simple and low-cost method based on matrix solid-phase dispersion (mspd) extraction, hplc separation, diode array detection and uplc-q-tof-ms have been developed for the determination of hydroxysafflor yellow a (hsya), kaempferol and other main compounds in carthamus tinctorius. the experimental parameters that may affect the mspd method, including dispersing sorbent, ratio of dispersing sorbent to sample, elution solvent, and volume of the elution solvent were examined and optimized. the opti ... | 2015 | 25676855 |
| safflower polysaccharide inhibits the proliferation and metastasis of mcf-7 breast cancer cell. | breast cancer accounts for 22.9% of all types of cancer in females worldwide. safflower polysaccharide (sps) is an active fraction purified from safflower petals (carthamus tinctorius l). the present study investigated the effects of safflower polysaccharide on the proliferation and metastasis of breast cancer cells. cell viability was analyzed using an mtt assay following treatment of the mcf‑7 cells with increasing concentrations of sps. the results demonstrated that the sps compound significa ... | 2015 | 25673029 |
| protective effects of hydroxysafflor yellow a (hsya) on alcohol-induced liver injury in rats. | hydroxysafflor yellow a (hsya), the main active natural constituent extracted from carthamus tinctorius l., has been widely used for the treatment of cerebrovascular and cardiovascular diseases. the aim of this study is to explore the effect of hsya on alcohol-induced liver injury and the underlying mechanism. male sprague-dawley rats were used to establish the liver injury model induced by alcohol. hsya treatment ameliorated serum biochemical indicators by reducing the levels of alanine aminotr ... | 2015 | 25626885 |
| herb-drug interaction between an anti-hiv chinese herbal sh formula and atazanavir in vitro and in vivo. | with the prevalent use of highly active antiretroviral therapy (haart) for aids patients since 1996, the mortality of hiv/aids patients has been remarkably decreased. with long-term use of haart, drug resistance and side effects of antiretrovirals have been frequently reported, which not only reduce the efficacy, but also decreases the tolerance of patients. traditional herbal medicine has become more popular among hiv/aids patients as adjuvant therapy to reduce these adverse effects of haart. s ... | 2015 | 25614104 |
| pharmacokinetic profiles of hydroxysafflor yellow a following intravenous administration of its pure preparations in healthy chinese volunteers. | hydroxysafflor yellow a (hsya), the major active marker compound isolated from carthamus tinctorius l., has been demonstrated to possess various attractive pharmacological activities. however, there is a lack of information about the complete clinical pharmacokinetic profiles of hsya following the administration of its pure preparations. the purpose of this study was to fully characterize the pharmacokinetic (pk) properties of hsya in healthy chinese volunteers following drip intravenous infusio ... | 2015 | 25576896 |
| barcoding melting curve analysis for rapid, sensitive, and discriminating authentication of saffron (crocus sativus l.) from its adulterants. | saffron (crocus sativus l.) is one of the most important and expensive medicinal spice products in the world. because of its high market value and premium price, saffron is often adulterated through the incorporation of other materials, such as carthamus tinctorius l. and calendula officinalis l. flowers, hemerocallis l. petals, daucus carota l. fleshy root, curcuma longa l. rhizomes, zea may l., and nelumbo nucifera gaertn. stigmas. to develop a straightforward, nonsequencing method for rapid, ... | 2014 | 25548775 |
| [separation and evaluation of antioxidant constituents from carthamus tinctorius]. | bio-active components from carthamus tinctorius were separated on the basis of antioxidant capacities in vitro. the antioxidant capacity was investigated on the basis of the ability to scavenge dpph radical, abts radical and reduce fe3+ of different polar fractions. furthermore, the chemical compounds were isolated from bio-active fraction, and were evaluated for the antioxidative effects. five major components were isolated and identified from water extract as 6-hydroxykaempferol 3,6,7-tri-o-β- ... | 2014 | 25522615 |
| screening antiallergic components from carthamus tinctorius using rat basophilic leukemia 2h3 cell membrane chromatography combined with high-performance liquid chromatography and tandem mass spectrometry. | carthamus tinctorius, used in traditional chinese medicine, has many pharmacological effects, such as anticoagulant effects, antioxidant effects, antiaging effects, regulation of gene expression, and antitumor effects. however, there is no report on the antiallergic effects of the components in c. tinctorius. in the present study, we investigated the antiallergic components of c. tinctorius and its mechanism of action. a rat basophilic leukemia 2h3/cell membrane chromatography coupled online wit ... | 2015 | 25521715 |
| a novel oral preparation of hydroxysafflor yellow a base on a chitosan complex: a strategy to enhance the oral bioavailability. | hydroxysafflor yellow a (hsya), the main active pharmaceutical ingredient of the safflower plant (carthamus tinctorius l.), is a hydrophilic drug with low oral bioavailability (ba). the objective of the present study was to improve the oral ba of hsya by formulation design. the effect of several pharmaceutical excipients on enhancing ba, including poloxamer 188 (p188), sodium caprate (sc), sodium deoxycholate, and β-cyclodextrin (β-cd), was investigated through animal models. sodium caprate, wit ... | 2015 | 25511808 |
| hydroxysafflor yellow a ameliorates lipopolysaccharide-induced acute lung injury in mice via modulating toll-like receptor 4 signaling pathways. | hydroxysafflor yellow a (hsya) is a main bio-active compound important of a traditional chinese medicine named carthamus tinctorius l. and has been shown to possess various effects, especially anti-inflammatory benefits and potential protections against acute lung injury (ali) in previous studies. therefore, in this present study, we aimed to evaluating effects of hsya on lipopolysaccharide (lps)-induced ali in mice. ali was induced by intratracheal instillation of lps into lung, and dexamethaso ... | 2014 | 25466274 |
| formula optimization of the jiashitang scar removal ointment and antiinflammatory compounds screening by nf-κb bioactivity-guided dual-luciferase reporter assay system. | inflammation plays a role in scar formation; therefore, decreasing inflammation benefits scar removal. jiashitang scar removal ointment (jst) is a commercially available traditional chinese medicinal formulation. it is composed of extracts from carthamus tinctorius l. (car), rheum officinale baill. (rhe), salvia miltiorrhiza beg. (sal), and panax notoginseng (burk.) f. h. chen (pan), which are all herbs with potent antiinflammatory activities. our aims are to optimize the formula of jst and to e ... | 2015 | 25363818 |
| characterization of the herb-derived components in rats following oral administration of carthamus tinctorius extract by extracting diagnostic fragment ions (dfis) in the ms(n) chromatograms. | in this study, a new strategy named extracting diagnostic fragment ions (dfis) in the ms(n) chromatograms [e(dfi)ms(n)cs] was proposed to rapidly detect and identify the in vivo components derived from the extract of carthamus tinctorius (ect), using high performance liquid chromatography coupled with hybrid ion trap-time of flight mass spectrometry. in order to comprehensively summarize the dfis for the global identification of in vivo constituents of ect, chemical profiling was carried out, an ... | 2014 | 25343164 |
| saffloflavonesides a and b, two rearranged derivatives of flavonoid c-glycosides with a furan-tetrahydrofuran ring from carthamus tinctorius. | two new rearranged derivatives of flavonoid c-glycosides, saffloflavonesides a (1) and b (2), were isolated from the florets of carthamus tinctorius. their structures were determined using uv, ir, hresims, and 1d and 2d nmr data and by comparing experimental and calculated electronic circular dichroism (ecd) spectra. compounds 1 and 2 were unprecedented chalcone and flavanone derivatives possessing a furan conjoining tetrahydrofuran ring. a potential biosynthetic pathway was proposed. at 10 μm, ... | 2014 | 25333381 |
| fatty acid composition and tocopherol profiles of safflower (carthamus tinctorius l.) seed oils. | the oil contents of safflower seeds ranged from 23.08% to 36.51%. the major fatty acid of safflower oil is linoleic acid, which accounted for 55.1-77.0% in oils, with a mean value of 70.66%. three types of tocopherols were found in safflower oil in various amount α-tocopherol, β-tocopherol and γ-tocopherol, ranged from 46.05 to 70.93 mg/100 g, 0.85 to 2.16 mg/100 g and trace amount to 0.45 mg/100 g oils, respectively. this research shows that both fatty acid and tocopherol contents differ signif ... | 2015 | 25329876 |
| two new quinochalcone c-glycosides from the florets of carthamus tinctorius. | two new quinochalcone c-glycosides, named hydroxysafflor yellow b (1) and hydroxysafflor yellow c (2), along with two known quinochalcone c-glycosides, safflomin c (3) and saffloquinoside c (4), and one known flavanone, (2r)-4',5-dihydroxyl-6, 7-di-o-β-d-glucopyranosyl flavanone (5), were isolated from the florets of carthamus tinctorius. their structures were determined by extensive spectroscopic (uv, ir, hr-esi-ms, 1d and 2d nmr) analyses. in addition, these quinochalcone c-glycosides together ... | 2014 | 25247575 |
| exploring the catalytic promiscuity of a new glycosyltransferase from carthamus tinctorius. | the catalytic promiscuity of a new glycosyltransferase (ugt73ae1) from carthamus tinctorius was explored. ugt73ae1 showed the capability to glucosylate a total of 19 structurally diverse types of acceptors and to generate o-, s-, and n-glycosides, making it the first reported trifunctional plant glycosyltransferase. the catalytic reversibility and regioselectivity were observed and modeled in a one-pot reaction transferring a glucose moiety from icariin to emodin. these findings demonstrate the ... | 2014 | 25191837 |
| devolopmental and growth temperature regulation of omega-3 fatty acid desaturase genes in safflower (carthamus tinctorius l.). | three ω-3 fatty acid desaturase genes (ctfad3, ctfad7, and ctfad8) were isolated from safflower (carthamus tinctorius l.). transcript analysis showed that the highest transcript levels were detected for ctfad3 and the low transcript levels were detected for ctfad7 and ctfad8 in flowers. this result indicates that ctfad3 enzyme activity is important for fatty acid desaturation in flowers. the low transcript level of ctfad3 in developing seeds was consistent with the recorded high level of linolei ... | 2014 | 25177943 |
| effect of flos carthami extract and α 1-adrenergic antagonists on the porcine proximal ureteral peristalsis. | traditional chinese medicine (tcm) has been proposed to prevent urolithiasis. in china, flos carthami (fc, also known as carthamus tinctorius) (safflower; chinese name: hong hua/) has been used to treat urological diseases for centuries. we previously performed a screening and confirmed the in vivo antilithic effect of fc extract. here, ex vivo organ bath experiment was further performed to study the effect of fc extract on the inhibition of phenylepinephrine (pe) (10(-4) and 10(-3) m) ureteral ... | 2014 | 25170340 |
| genetic diversity in carthamus tinctorius (asteraceae; safflower), an underutilized oilseed crop. | • | 2014 | 25096251 |
| [optimization of ultrasonic extraction conditions of safflower yellow from carthamus tinctorius by response surface methodology]. | to investigate the optimization of extraction conditions of safflower yellow from cartbamus tirwtorius by response surface methodology. | 2013 | 25090689 |
| hydroxysafflor yellow a attenuates small airway remodeling in a rat model of chronic obstructive pulmonary disease. | our previous studies found that hydroxysafflor yellow a (hsya), an active ingredient in carthamus tinctorius l., has anti-inflammatory and anti-fibrosis properties. in this study, we investigated the effect of hsya on small airway remodeling (sar) in a chronic obstructive pulmonary disease (copd) rat model induced by cigarette smoke and lipopolysaccharide (lps). sar is a common lesion in copd characterized by thickening of the airway wall, mainly by subepithelial fibrosis. in this study the thic ... | 2014 | 25056232 |
| histological, ultrastructural and biochemical studies on the kidney of mice treated with carthamus tinctorius l. extract. | carthamus tinctorius l. (c. tinctorius) is used as a food additive but also has medicinal applications. the present work was designed to investigate its probable side effects on the histology and function of the kidney in the mice. | 2013 | 25050283 |
| effects of carthamus tinctorius l. on the ovarian histomorphology and the female reproductive hormones in mice. | carthamus tinctorius l. (safflower) is a member of the asteraceae family which had been classified as a fertility regulator in the traditional medicine. the purpose of this study was to investigate its possible effects on the ovarian histomorphology and the levels of female reproductive hormones in the mice. | 2013 | 25050271 |