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a temporal -omic study of propionibacterium freudenreichii cirm-bia1 adaptation strategies in conditions mimicking cheese ripening in the cold.propionibacterium freudenreichii is used as a ripening culture in swiss cheese manufacture. it grows when cheeses are ripened in a warm room (about 24°c). cheeses with an acceptable eye formation level are transferred to a cold room (about 4°c), inducing a marked slowdown of propionic fermentation, but p. freudenreichii remains active in the cold. to investigate the p. freudenreichii strategies of adaptation and survival in the cold, we performed the first global gene expression profile for this ...201222253706
the role of rifampin against propionibacterium acnes biofilm in vitro and in an experimental foreign-body infection model.propionibacterium acnes is an important cause of orthopedic implant-associated infections, for which the optimal treatment has not yet been determined. we investigated the activity of rifampin, alone and in combination, against planktonic and biofilm p. acnes in vitro and in a foreign-body infection model. the mic and the minimal bactericidal concentration (mbc) were 0.007 and 4 μg/ml for rifampin, 1 and 4 μg/ml for daptomycin, 1 and 8 μg/ml for vancomycin, 1 and 2 μg/ml for levofloxacin, 0.03 a ...201222252806
reply: "follicular spicules associated with propionibacterium acnes with response to erythromycin": lack of evidence for the species? 201222225404
intratumoral injection of propionibacterium acnes suppresses malignant melanoma by enhancing th1 immune responses.malignant melanoma (mm) is an aggressive cutaneous malignancy associated with poor prognosis; many putatively therapeutic agents have been administered, but with mostly unsuccessful results. propionibacterium acnes (p. acnes) is an aerotolerant anaerobic gram-positive bacteria that causes acne and inflammation. after being engulfed and processed by phagocytes, p. acnes induces a strong th1-type cytokine immune response by producing cytokines such as il-12, ifn-γ and tnf-α. the characteristic th2 ...201122216160
factors affecting microbial contamination rate of cord blood collected for transplantation.background: collection and processing of cord blood (cb) is associated with significant risk of microbial contamination and hence relevant standards mandate microbial screening of the final product. this study aimed to determine the contamination rate and associated risk factors during 14 years of banking at the sydney cord blood bank. study design and methods: cb was collected and processed using a closed system and tested for contamination using blood culture bottles (bact/alert, biomérieux) i ...201122211719
Multilocus Sequence Typing (MLST) and Phylogenetic Analysis of Propionibacterium acnes.Propionibacterium acnes is a commensal of human skin but is also implicated in the pathogenesis of acne vulgaris and in biofilm-associated infections of medical devices and endophthalmitis, and in infections of bone and dental root canals. Recent studies associate P. acnes with prostate cancer. As the species includes evolutionary lineages with distinct association with health and disease, there is a need for a high-resolution typing scheme. Recently, two MLST schemes were reported, one based on ...201122205788
influence of lactose and lactate on growth and β-galactosidase activity of potential probiotic propionibacterium acidipropionici.dairy propionibacteria are microorganisms of interest for their role as starters in cheese technology and as well as their functions as probiotics. previous studies have demonstrated that propionibacterium acidipropionici metabolize lactose by a β-galactosidase that resists the gastrointestinal transit and the manufacture of a swiss-type cheese, so that could be considered for their inclusion in a probiotic product assigned to intolerant individuals. in the present work we studied the effect of ...201122202442
molecular detection of in-vivo microbial contamination of metallic orthodontic brackets by checkerboard dna-dna hybridization.knowing the microbiota that colonizes orthodontic appliances is important for planning strategies and implementing specific preventive measures during treatment. the purpose of this clinical trial was to evaluate in vivo the contamination of metallic orthodontic brackets with 40 dna probes for different bacterial species by using the checkerboard dna-dna hybridization (cddh) technique.201222196182
microbial production of propionic acid with propionibacterium freudenreichii using an anion exchanger-based in situ product recovery (ispr) process with direct and indirect contact of cells.the recovery of an inhibiting product from a bioreactor soon after its formation is an important issue in industrial bioprocess development. in the present study, the potential of the anion exchanger-based in situ product recovery (ispr) technique for the biocatalytic production of propionic acid was discussed. the focus of the current work was the selection of a suitable configuration of metabolically active cells for application in propionic acid production. accumulation of propionic acid in f ...201122194053
efficiency of diversion of the first aliquot of blood and prestorage leukoreduction for preventing bacterial contamination in red blood cell concentrates assessed using a rapid polymerase chain reaction-based bacterial detection system.sepsis caused by the bacterial contamination of blood products is a major infection risk associated with blood transfusion. diversion of the initial 25 ml of blood and prestorage leukoreduction were implemented in japan in 2007 for all donated blood products. we assessed the efficacy of these new collection procedures in preventing bacterial contamination of red blood cell (rbc) concentrates.201122191101
[influence of substances produced by lipophilic corynebacterium cdc g1 zmf 3p13 on the microorganisms inhabiting human skin].lipophilic species of corynebacterium inhabiting skin as residents produces substances that can regulate the composition of natural flora. research that was carried out concerned an influence of the substances produced by corynebacterium cdc g1 zmf 3p13 on the set of 22 bacterial strains (staphylococcus spp., corynebacterium spp., propionibacterium spp.) mutually existing on the skin and the set of 6 candida spp. isolated from patients. it was found out that the strain gives off into environment ...201122184896
Vitamin B(12) production from crude glycerol by Propionibacterium freudenreichii ssp. shermanii: Optimization of medium composition through statistical experimental designs.A two-step statistical experimental design was employed to optimize the medium for vitamin B(12) production from crude glycerol by Propionibacterium freudenreichii ssp. shermanii. In the first step, using Plackett-Burman design, five of 13 tested medium components (calcium pantothenate, NaH(2)PO(4)·2H(2)O, casein hydrolysate, glycerol and FeSO(4)·7H(2)O) were identified as factors having significant influence on vitamin production. In the second step, a central composite design was used to optim ...201222178491
Corynebacterium pyruviciproducens promotes the production of ovalbumin specific antibody via stimulating dendritic cell differentiation and up-regulating Th2 biased immune response.Corynebacterium pyruviciproducens (C. pyruviciproducens), a newly discovered Corynebacterium, is gram-positive, non-flagellate, non-spore-forming lipophilic rod. No known pathogenic components of Corynebacteria have been found in this new bacterium, such as diphtheria toxin and tuberculostearic acid. In the present study, referring to Propionibacterium acnes (P. acnes), a well-known bacterial adjuvant, the stimulation of dendritic cells by C. pyruviciproducens was analyzed through detecting the ...201122178104
[In Process Citation]. 201122168009
in vitro antibacterial and anti-inflammatory properties of seaweed extracts against acne inducing bacteria, propionibacterium acnes.this study was conducted to evaluate the antimicrobial activities of common seaweeds from the coast of south korea against the etiologic agents of acne vulgaris. fifty-seven species of seaweed were screened for potential antimicrobial activity. methanol extracts of 13 species (22.8%) showed inhibitory effects against propionibacterium acnes. the aqueous extracts of only two species (3.5%) showed antimicrobial activity. when tested with the agar disk diffusion method, ecklonia cava, e. kurome, is ...201122167943
profiling of dental plaque microflora on root caries lesions and the protein-denaturing activity of these bacteria.to profile plaque microflora on root-caries lesions, and to examine the protein-denaturing activity as a pilot study.201122165457
validation of the bact/alert(®)3d automated culture system for the detection of microbial contamination of epithelial cell culture medium.living tissue engineering for regenerative therapy cannot withstand the usual pharmacopoeia methods of purification and terminal sterilization. consequently, these products must be manufactured under aseptic conditions at microbiologically controlled environment facilities. this study was proposed to validate bact/alert(®)3d automated culture system for microbiological control of epithelial cell culture medium (eccm). suspensions of the nine microorganisms recommended by the european pharmacopoe ...201122160810
genome sequence of propionibacterium acnes type ii strain atcc 11828.propionibacterium acnes is an anaerobic gram-positive bacterium that forms part of the normal human cutaneous microbiota and is occasionally associated with inflammatory diseases (i. kurokawa et al., exp. dermatol. 18:821-832, 2009). here we present the complete genome sequence for the commercially available p. acnes type ii reference strain atcc 11828 (i. nagy et al., microbes infect. 8:2195-2205, 2006) recovered from a subcutaneous abscess.201222156398
Periprosthetic infections after shoulder hemiarthroplasty.BACKGROUND: To examine the rates and predictors of deep periprosthetic infections after shoulder hemiarthroplasty. METHODS: We used prospectively collected institutional registry data on all primary shoulder hemiarthroplasty patients from 1976-2008. We estimated survival free of deep periprosthetic infections using Kaplan-Meier survival curves. Using univariate Cox regression analyses, we examined the association of patient-related factors (age, sex, body mass index), comorbidity (Deyo-Charlson ...201122154310
improvement of rna-sip by pyrosequencing to identify putative 4-n-nonylphenol degraders in activated sludge.nonylphenols (np) have estrogenic potential because of their phenolic ring, but the organisms involved in the degradation of this alkylated phenol remain unidentified. using 16s ribosomal rna (rrna)-based stable isotope probing (sip) and a new method based on pyrosequencing, we identified the bacteria involved in the degradation of the aromatic ring of [u-ring-(13)c] 4-n-np in aerobic sludge. the first order degradation rate of 4-n-np was 5.5d(-1). single strand conformation polymorphism of dens ...201122154106
Diethylene glycol monoethyl ether: an emerging solvent in topical dermatology products.Background The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. Dermatologists are already treating patients that apply products containing 5-40% of this solvent multiple times each day. Aims To provide dermato ...201122151944
Efficacy and safety of topical nadifloxacin and benzoyl peroxide versus clindamycin and benzoyl peroxide in acne vulgaris: A randomized controlled trial.Topical therapy with comedolytics and antibiotics are often advocated for mild and moderate severity acne vulgaris. Nadifloxacin, a new fluoroquinolone with anti-Propionibacterium acnes activity and additional anti-inflammatory activity, is approved for use in acne. This randomized controlled assessor blind trial compared the clinical effectiveness and safety of eight weeks therapy of nadifloxacin 1% versus clindamycin 1% as add-on therapy to benzoyl peroxide (2.5%) in mild to moderate grade acn ...201122144763
first report of high levels of clindamycin-resistant propionibacterium acnes carrying erm(x) in japanese patients with acne vulgaris. 201122142418
Progression of cerebrospinal fluid cell count and differential over a treatment course of shunt infection.Object The physiological reaction of CSF white blood cells (WBCs) over the course of treating a shunt infection is undefined. The authors speculated that the CSF WBC count varies with different infecting organisms in peak level and differential percentage of polymorphonuclear (PMN) leukocytes, lymphocytes, monocytes, and eosinophils. The authors hope to identify clinically useful trends in the progression of CSF WBCs by analyzing a large group of patients with successfully treated shunt infect ...201122132920
Proceedings of the 3rd International Symposium on Propionibacteria and Bifidobacteria: dairy and probiotic applications, 1-4 June, 2010, Spain. 201122128394
human bocavirus in the nasopharynx of otitis-prone children.human bocavirus (hbov) is frequently identified in children with respiratory tract infections, and its role in acute otitis media (aom) has been suggested. the disease associations for the closely related bocaviruses hbov2-4 remain unknown. increasing evidence shows that probiotics may reduce the risk of aom of viral origin. objectives of the study was to examine the prevalence and persistence of bocaviruses in consecutive nasopharyngeal samples (nps) of otitis-prone children, and whether an ass ...201122119148
Propionibacterium acnes: infection beyond the skin.Propionibacterium acnes is a Gram-positive bacterium that forms part of the normal flora of the skin, oral cavity, large intestine, the conjunctiva and the external ear canal. Although primarily recognized for its role in acne, P. acnes is an opportunistic pathogen, causing a range of postoperative and device-related infections. These include infections of the bones and joints, mouth, eye and brain. Device-related infections include those of joint prostheses, shunts and prosthetic heart valves. ...201122114965
antibiotic-resistant propionibacterium acnes among acne patients in a regional skin centre in hong kong.background  there has been no study on antibiotic-resistant propionibacterium acnes in hong kong. objective  we investigated the prevalence and pattern of antibiotic-resistant p. acnes and to identify any associated factors for harbouring the resistant strains. methods  culture and sensitivity testing of p. acnes to commonly used antibiotics were performed. resistance to tetracycline was defined at a minimal inhibitory concentration (mic) of 2 μg/ml or more; erythromycin at an mic of 0.5 μg/ml o ...201122103749
topical dose justification: benzoyl peroxide concentrations.abstract background: benzoyl peroxide (bpo) is widely utilized in acne treatment as an alternative to antibiotics against which propionibacterium acnes becomes more resistant. objective: this overview examines bpo dose justification. methods: pubmed, embase® and science citation index searches were conducted using the keywords "benzoyl peroxide" and "acne vulgaris". results: limited experimental data are available. however, there appears no significant difference in the efficacy of concentrat ...201122103743
The SAPHO syndrome--are microbes involved?The syndrome of synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) includes a rare group of chronic, relapsing, inflammatory osteoarticular disorders that is conventionally associated with manifestations in the skin. Diagnostic dilemmas can arise due to incomplete manifestations or confusion generated through mimicking of other conditions, such as osteomyelitis. The aetiology of this syndrome remains unclear, but probably involves genetic, immunological and infectious mechanisms. The ...201122100290
Persistent extraradicular infection in root-filled asymptomatic human tooth: scanning electron microscopic analysis and microbial investigation after apical microsurgery.Procedural accidents have a negative effect on healing and might contribute to the persistence of infections in inaccessible apical areas, requiring surgical intervention. This report describes a case of persistent apical periodontitis of a lower left first molar associated with the sinus tract and a periapical lesion that required nonsurgical endodontic retreatment and apical surgery for resolution.201122099908
The importance of a multifaceted approach to characterizing the microbial flora of chronic wounds.Chronic wounds contain complex polymicrobial communities of sessile organisms that have been underappreciated because of limitations of standard culture techniques. The aim of this work was to combine recently developed next-generation investigative techniques to comprehensively describe the microbial characteristics of chronic wounds. Tissue samples were obtained from 15 patients with chronic wounds presenting to the Johns Hopkins Wound Center. Standard bacteriological cultures demonstrated an ...201122092791
newer approaches in topical combination therapy for acne.acne vulgaris is a common chronic inflammatory cutaneous disease involving the pilosebaceous unit. its pathophysiology is multifactorial and complex, including obstruction of the pilosebaceous unit due to increased sebum production, abnormal keratinization, proliferation of propionibacterium acnes (p. acnes), and inflammation. topical agents are the most commonly used therapy for acne. first generation topicals mainly consist of single agent retinoids, benzoyl peroxide (bpo) and antibacterials t ...201122089505
susceptibility of propionibacterium acnes isolated from patients with acne vulgaris to zinc ascorbate and antibiotics.the in vitro antimicrobial activity of ascorbic acid derivatives against propionibacterium acnes was tested either alone or in combination with a variety of antimicrobial agents, and their fractional inhibitory concentration index was determined using checkerboard tests. the antimicrobial effectiveness of zinc ascorbate in the treatment of acne vulgaris, either alone or in combination with antibiotics such as clindamycin that are commonly used in japan for the treatment of acne vulgaris, was the ...201122087070
single nucleotide polymorphisms of toll-like receptor-4 protect against acne conglobata.background  former studies have shown that propionibacterium acnes may stimulate expression of toll-like receptor 4 (tlr4) in keratinocytes of patients with acne vulgaris. objective  to investigate the impact of single nucleotide polumorphisms (snps) of the tlr4 gene in acne vulgaris. methods  genomic dna was isolated from 191 patients with acne vulgaris and 75 healthy controls. asp299gly and thr399ile snps were defined after cutting of the pcr products by restriction enzymes. sebum of lesions w ...201122085193
novel in situ product removal technique for simultaneous production of propionic acid and vitamin b12 by expanded bed adsorption bioreactor.a new type of in situ product removal (ispr) technique of expanded bed adsorption (eba) bioreactor was studied to simultaneously produce extracellular propionic acid and intracellular vitamin b12 by propionibacterium freudenreichii cicc 10019. resin screening experiments showed that the zga330 resin have the best biocompatibility and highest adsorption for propionic acid. through the eba bioreactor, propionic acid could be recovered efficiently by semi-continuous recirculation of the unfiltered ...201222082511
Efficient electricity generation from sewage sludge usingbiocathode microbial fuel cell.Microbial fuel cells (MFCs) with abiotic cathodes require expensive catalyst (such as Pt) or catholyte (such as hexacynoferrate) to facilitate oxidation reactions. This study incorporated biocathodes into a three-chamber MFC to yield electricity from sewage sludge at maximum power output of 13.2±1.7W/m(3) during polarization, much higher than those previously reported. After 15d operation, the total chemical oxygen demand (TCOD) removal and coulombic efficiency (CE) of cell reached 40.8±9.0% and ...201222078254
[Drug sensitivity of causative agents in ocular infection of external adnexa and anterior segments--multicenter study of causative agents and drug sensitivity of ocular infection by the Japanese Association for Ocular Infection part II].To report the drug sensitivity of causative agents produced by ocular infection of external adnexa and anterior segments investigated by the nationwide survey conducted by Japanese Association for Ocular Infection between September, 2007 and August, 2008.201122073598
[determination of causative agents in ocular infection of external adnexa and anterior segments--multicenter study of causative agents and drug sensitivity of ocular infection by the japanese association for ocular infection part i].to determine the causative agents of ocular infection of external adnexa and anterior segments due to selected criteria.201122073597
comparative photodynamic evaluation of new phenothiazinium derivatives against propionibacterium acnes(†).the screening of recently patented derivatives of the standard phenothiazinium agents methylene blue and toluidine blue was carried out against propionibacterium acnes, the main bacterium associated with acne vulgaris. comparative tests were made using the topical agent benzoyl peroxide (bpo) and standard tetracyclines. each of the photosensitizers employed, including the lead compounds, was photobactericidal at lower concentrations than bpo, and produced a much more rapid kill than the tetracyc ...201122043962
delayed- versus acute-onset endophthalmitis after cataract surgery.purpose: to report a large consecutive case series of patients who developed delayed-onset and acute-onset endophthalmitis after cataract surgery. design: retrospective consecutive case series. methods: the current study is a retrospective consecutive case series of patients treated between january 2000 and december 2009 for culture-proven endophthalmitis after cataract surgery. the study defined 2 groups after cataract surgery: acute-onset endophthalmitis (≤6 weeks after surgery) and delayed-on ...201122030353
aberrant structures of fecal bacterial community in allergic infants profiled by 16s rrna gene pyrosequencing.we investigated the correlation between fecal bacteria composition in early infancy and the prevalence of allergic diseases in late infancy. the fecal microbiota in the first 2 months was profiled using the 16s rrna v6 short-tag sequences in the community and statistically compared between two groups of subjects who did and did not show allergic symptoms in the first 2 years (n = 11 vs. 11). in the allergic group, genus bacteroides at 1 month and genera propionibacterium and klebsiella at 2 mont ...201122029688
Acid-bile, antibiotic resistance and inhibitory properties of propionibacteria isolated from Turkish traditional home-made cheeses.In this study, a total of 29 Propionibacterium spp. were isolated from traditional home-made Turkish cheese samples. As a result of the identification, isolates were identified as Propionibacterium freudenreichii subsp. freudenreichii (15 strains), Propionibacterium jensenii (12), and Propionibacterium thoenii (2). All isolates and 5 reference strains were examined for their abilities to survive at pH 2.0, 3.0, 4.0, 5.0 and in the presence of 0.06, 0.15 and 0.30% bile salts, their influence on t ...201122019987
Facial nerve palsy caused by parotid gland abscess.Objectives:We present the first report of methicillin-resistant Staphylococcus aureus and Propionibacterium acnes parotid abscesses complicated by facial nerve palsy. Facial nerve palsy secondary to parotid gland abscess is rare, with only eight previously reported cases.Method:Case reports and literature review concerning parotid abscess and facial nerve palsy presentation and management.Case reports:Within two months, two female patients presented with parotid gland abscess complicated by unil ...201122017803
Investigation of Propionibacterium acnes in progressive macular hypomelanosis using real-time PCR and culture.Progressive macular hypomelanosis (PMH) is a dermatosis of unknown etiology. It has been concluded that it involves the presence of Propionibacterium acnes, a saprophyte of the pilosebaceous follicles. In our study, we investigated the presence of P. acnes in lesional and non-lesional skin of patients with PMH through quantitative real-time polymerase chain reaction (PCR) and bacterial culture from a skin fragment.201122004486
butyric acid- and dimethyl disulfide-assimilating microorganisms in a biofilter treating air emissions from a livestock facility.biofiltration has proven an efficient tool for the elimination of volatile organic compounds (vocs) and ammonia from livestock facilities, thereby reducing nuisance odors and ammonia emissions to the local environment. the active microbial communities comprising these filter biofilms have not been well characterized. in this study, a trickle biofilter treating air from a pig facility was investigated and proved efficient in removing carboxylic acids (>70% reduction), mainly attributed to the pri ...201122003018
Anti-in?ammatory effects of active constituents extracted from Chinese medicinal herbs against Propionibacterium acnes.Interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-a) from keratinocyte play important roles in initiating the inflammatory process of acne. They are used as major elements to evaluate the anti-inflammatory activity of drugs. In this study, various active constituents extracted from Chinese medicinal herbs were tested for their anti-inflammatory effects against P. acnes using ELISA. Among the constituents, matrine, baicalin, ursolic acid, sodium danshensu, magnolol, honokiol, hesperidin ...201121999396
The use of lymecycline and benzoyl peroxide for the treatment of progressive macular hypomelanosis: a prospective study.Progressive macular hypomelanosis is a dermatosis of uncertain etiology. The participation of Propionibacterium acnes has been suggested in view of the response achieved following therapy with drugs that are active against this bacterium. This report describes a series of thirteen patients with progressive macular hypomelanosis who were treated with an association of lymecycline and benzoyl peroxide over a three-month period. Response to treatment was excellent and the positive results were main ...201121987158
molecular relatedness of propionibacterium species isolated from blood products and on the skin of blood donors.in this study it was investigated whether propionibacterium acnes present in platelet concentrates (pcs) and related red blood cells (rbcs), originate from the skin of the donor.201121985045
Fate of Escherichia coli O26 in Corn Silage Experimentally Contaminated at Ensiling, at Silo Opening, or after Aerobic Exposure, and Protective Effect of Various Bacterial Inoculants.Shiga toxin-producing Escherichia coli (STEC) strains are responsible for human illness. Ruminants are recognized as a major reservoir of STEC, and animal feeds, such as silages, have been pointed out as a possible vehicle for the spread of STEC. The present study aimed to monitor the fate of pathogenic E. coli O26 strains in corn material experimentally inoculated (10(5) CFU/g) during ensiling, just after silo opening, and after several days of aerobic exposure. The addition of 3 bacterial inoc ...201121984243
Glycolic acid chemical peeling improves inflammatory acne eruptions through its inhibitory and bactericidal effects on Propionibacterium acnes.Glycolic acid chemical peeling is effective for treating comedones, and some clinical data show that it also improves inflammatory eruptions. The purpose of this study was to identify the mechanism of glycolic acid chemical peeling to improve inflammatory acne. To assess growth inhibitory and bactericidal effects of glycolic acid on Propionibacterium acnes in vitro, we used an agar diffusion method and a time-kill method. To reveal bactericidal effects in vivo, we established an agar-attached me ...201121950544
Heme Oxygenase-1 Alleviates Mouse Hepatic Failure through Suppression of Adaptive Immune Responses.Heme oxygenase-1 (HO-1) has protective effects on liver damage induced by noxious stimuli. The mechanism of action of HO-1 is not well understood. In the present study, we investigate the effect of HO-1 in a model of fulminant hepatic failure induced by Propionibacterium acnes and lipopolysaccharide (LPS). The expression of HO-1 mRNA and protein in the liver was increased after repeated administration of the HO-1 inducer cobalt protoporphyrin IX. We found that HO-1 protected mice from acute live ...201221946119
Neolitsea aciculata essential oil inhibits drug-resistant skin pathogen growth and Propionibacterium acnes-induced inflammatory effects of human monocyte leukemia.This study examined the chemical composition of Neolitsea aciculata essential oil (NAE) and its biological activities. NAE was obtained by hydro-distillation of N. aciculata leaves collected in Jeju Island and analyzed by gas chromatography equipped with a mass spectrometer detector. 1-Dodecen-3-yne (12.5%), calarene (11.5%) and elemol (9.5%) were identified as the major components of NAE. The antibacterial and anti-inflammatory activities of NAE against skin pathogens were examined to determine ...201121922933
granulomatous propionibacterium acnes infection after trauma surgery.we report here a rare case of infection caused by propionibacterium acnes following trauma surgery: a 36-year-old male, accident victim was admitted to the hospital because of polytrauma. he underwent a long-drawn-out surgical intervention and after a free-muscle transfer using the rectus femoris muscle, signs of inflammation were detected in the affected area. microbiological examination of the wound revealed the presence of p. acnes as the only etiological agent of this infection. adequate ant ...201121911069
the breast: a clean-contaminated surgical site.capsular contracture is one of the most common complications associated with breast implants. while the cause of this process has not yet been elucidated, subclinical infection is a likely culprit.201121908811
primary total joint arthroplasty performed in operating rooms following cases of known infection.no study has examined infection rates in "clean" cases following "dirty" cases. this study evaluated patients undergoing elective primary total joint arthroplasties performed in operating rooms following cases of known infection for development of postoperative infection. a retrospective review of all elective primary total joint arthroplasties performed over a 5-year period at our institution was conducted. patients who underwent primary total joint arthroplasties that followed cases of known i ...201121902154
uv induced red fluorescence of the acne patients reflects regional casual sebum level and acne lesion distribution: qualitative and quantitative analyses of facial fluorescence.background:  the uv-induced red fluorescence of the acne patients had been considered to be caused by propionibacterium acnes. objectives:  to study the correlation of the facial red fluorescence with the casual sebum level and the number of acne lesions and to investigate the difference in clinical features, according to both distribution and proportion of fluorescence. methods:  a total of 878 patients, clinically diagnosed with acne vulgaris, were included. the inflammatory and non-inflammato ...201121895623
Acne vulgaris.Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production, altered keratinisation, inflammation, and bacterial colonisation of hair follicles on the face, neck, chest, and back by Propionibacterium acnes. Although early colonisation with P acnes and family history might have important roles in the disease, exactly what triggers acne and how treatment affects the course of the disease remain unclear. Other factors such as diet have ...201121880356
Acne vulgaris.Acne vulgaris is one of the most common dermatological diseases, and caused by a combination of pathogenetic factors including follicular hyperkeratosis, seborrhea, colonization with Propionibacteriumacnes and inflammatory phenomena. Various medical treatments address these causative factors, but they are not always well tolerated. In the last decades, there has been increased interest in laser and light-based treatments. These optical devices mainly target Propionibacteriumacnes by activating p ...201121865806
antibacterial properties of a glycolipid-rich extract and active principle from nunavik collections of the macroalgae fucus evanescens c. agardh (fucaceae).this study investigated the antibacterial activity of glycolipid-rich extracts of the brown macroalga fucus evanescens in cell culture. accessions were collected on the arctic coast of ungava bay, nunavik, quebec. the crude ethyl acetate extract of these accessions showed strong antibacterial activity (≥4 log(10) cfu) against hemophilus influenzae , legionella pneumophila , propionibacterium acnes (atcc and clinical isolate), and streptococcus pyogenes at 100 µg/ml. this algal extract inhibited ...201121859295
Effects of the addition of direct-fed microbials and glycerol to the diet of lactating dairy cows on milk yield and apparent efficiency of yield.A study was conducted to evaluate the effects of a direct-fed microbial (M) and dietary glycerol (G) on milk yield, efficiency of yield, and nutrient digestibility during hot weather. Sixty Holstein cows averaging 120 d in milk (DIM) and 36.2 kg/d of milk were used in a 12-wk 2×2 factorial design trial from June through September 2008. Cows were fed a common diet during the 2-wk standardization period and were blocked by milk yield, DIM, parity, and dry matter intake. Diets were based on corn an ...201121854934
classification of swiss cheese starter and adjunct cultures using fourier transform infrared microspectroscopy.the acceptability of swiss cheese largely depends on the flavor profile, and strain variations of cheese cultures will affect the final quality. conventional biochemical methods to identify the cultures at the strain level are time-consuming and expensive, and require skilled labor. our objective was to develop rapid classification methods of starter cultures at the strain level by using a combination of hydrophobic grid membrane filters and fourier transform infrared (ftir) spectroscopy. forty- ...201121854910
[a white woman with white skin spots].a 26-year-old white woman came to the clinic because of white spots. the spots were confluent in the midline, non-scaly and localized on trunk and proximal parts of the arms. biopsy showed loss of pigment in the epidermis. the diagnosis was: progressive macular hypomelanosis.201121854654
analysis of symptomatic and asymptomatic primary root canal infections in adult norwegian patients.this molecular study analyzed the microbiota of primary root canal infections from adult norwegian patients.201121846535
[bacteriology of ethmoidal sinus in chronic rhinosinusitis with and without nasal polyps].to compare the bacteriologic features of anterior ethmoidal biopsy specimens between chronic rhinosinusitis without nasal polyps (crsnp-), chronic rhinosinusitis with nasal polyps(crsnp+) and control patients.201121845823
study of human microecology by mass spectrometry of microbial markers.this review shows that mass spectrometry of microbial markers (msmm) permits simultaneous in situ determination of more than one hundred microbial fatty acids in clinical, biotechnological or environmental samples, without precultivation and use of biochemical test materials and primers. unprecedented information about the quantity of anaerobes and uncultivated aerobes, as well as actinobacteria, yeasts, viruses and microscopic fungi in one sample has provided a full understanding of microbial e ...201121831791
effect of probiotic propionibacterium jensenii 702 supplementation on layer chicken performance.the effects of the probiotic, propionibacterium jensenii 702 (pj 702), supplementation on egg productivity, egg shell thickness, fatty acid profile of eggs, and body weight in early layer hens were investigated. twenty eight twenty-week-old starter pullets were evenly divided into a treatment and a control group for an eight week experiment. each bird in the treatment group received 107 cfu pj 702 daily in a total volume of 1 ml by oral administration. no adverse effect was observed due to admin ...201021831750
characterization of bacterial community diversity in chronic rhinosinusitis infections using novel culture-independent techniques.chronic rhinosinusitis (crs) with or without polyps is a common chronic upper airway condition of multifactorial origin. fundamental to effective treatment of any infection is the ability to accurately characterize the underlying cause. many studies have shown that only a small fraction of the total range of bacterial species present in crs is detected through conventional culture-dependent techniques. consequently, culture data are often unrepresentative of the true diversity of the microbial c ...201121819748
chronic infective endarteritis due to propionibacterium acnes on aortic prosthetic graft. 201121794971
cathelicidin-bf, a snake cathelicidin-derived antimicrobial peptide, could be an excellent therapeutic agent for acne vulgaris.cathelicidins are a family of antimicrobial peptides acting as multifunctional effector molecules in innate immunity. cathelicidin-bf has been purified from the snake venoms of bungarus fasciatus and it is the first identified cathelicidin antimicrobial peptide in reptiles. in this study, cathelicidin-bf was found exerting strong antibacterial activities against propionibacterium acnes. its minimal inhibitory concentration against two strains of p. acnes was 4.7 µg/ml. cathelicidin-bf also effec ...201121789223
effect of applying bacterial inoculants containing different types of bacteria to corn silage on the performance of dairy cattle.this study examined the effect of applying different bacterial inoculants to corn silage at the time of ensiling on the performance of lactating dairy cows. corn plants were harvested at 35% dry matter (dm), chopped, and ensiled in 2.4-m-wide bags after application of (1) no inoculant (con); (2) biotal plus ii (b2) containing pediococcus pentosaceus and propionibacteria freudenreichii; (3) buchneri 40788 (buc) containing lactobacillus buchneri; or (4) buchneri 500 (b500) containing pediococcus p ...201121787933
folliculitis et perifolliculitis capitis abscedens et suffodiens controlled with a combination therapy: systemic antibiosis (metronidazole plus clindamycin), dermatosurgical approach, and high-dose isotretinoin.folliculitis et perifolliculitis capitis abscedens et suffodiens is a rare disease of unknown etiology. it is a suppurative process that involves the scalp, eventually resulting in extensive scarring and irreversible alopecia. the condition is also known as 'acne necrotica miliaris' or 'proprionibacterium' folliculitis. most often the disease affects men of african-american or african-caribbean descent between 20 and 40 years of age. the clinical picture is determined by fluctuating painful fist ...201121772598
in vitro antibacterial activity of nb-003 against propionibacterium acnes.nb-003 and nb-003 gel formulations are oil-in-water nanoemulsions designed for use in bacterial infections. in vitro susceptibility of propionibacterium acnes to nb-003 formulations and comparator drugs was evaluated. both nb-003 formulations were bactericidal against all p. acnes isolates, including those that were erythromycin-, clindamycin- and/or tetracycline-resistant. in the absence of sebum the mic(90)/mbc(90) values for nb-003, nb-003 gel, salicylic acid (sa), and benzoyl peroxide (bpo) ...201121746943
[postoperative recurrence of subdural empyema].we present a case of recurrent subdural post-surgical empyema by proprionibacterium acnes after a first drained empyema in which no microbiological diagnosis was reached. p. acnes is a gram-positive anaerobic organism which is part of the saprophytic flora of the skin and others parts of the body. however, it can cause infections, as in the central nervous system, especially post-surgical infections in which can be the second more frequent organism after staphylococcus aureus. p. acnes grows slo ...201121743949
cognitive deficits after systemic induction of inducible nitric oxide synthase: a randomised trial in rats.background: nitric oxide acts as an important neurotransmitter as well as a sepsis mediator. during sepsis, high levels of nitric oxide, produced by the inducible form of the nitric oxide synthase (inos), may lead to disturbances concerning these conflicting roles and cause septic encephalopathy. to evaluate this theory, we aimed at first, to demonstrate cognitive dysfunction in a rat model based on systemic inos induction; second, to elucidate molecular mechanisms; and third, to prevent cogniti ...201121743335
comparative genomics and transcriptomics of propionibacterium acnes.the anaerobic gram-positive bacterium propionibacterium acnes is a human skin commensal that is occasionally associated with inflammatory diseases. recent work has indicated that evolutionary distinct lineages of p. acnes play etiologic roles in disease while others are associated with maintenance of skin homeostasis. to shed light on the molecular basis for differential strain properties, we carried out genomic and transcriptomic analysis of distinct p. acnes strains. we sequenced the genome of ...201121738717
clearance of propionibacterium acnes by kupffer cells is regulated by osteopontin through modulating the expression of p47phox.osteopontin (opn) is a cytokine with multiple functions, including the regulation of innate immune response. however, the detailed function and mechanism of opn in host defense against invaded microorganisms remain unclear. in this report, we revealed that opn could affect the clearance of propionibacterium acnes in kupffer cells. in a murine model of p. acnes induced hepatic granuloma, opn-deficient mice or wild-type (wt) mice treated with anti-opn mab exhibited more hepatic granuloma formation ...201121737140
phenotypic identification of over 1000 isolates of anaerobic bacteria recovered between 1999 and 2008 in a major costa rican hospital.because of limitations in infrastructure, the aetiology of infections caused by anaerobic bacteria is seldom determined in clinical laboratories of developing countries. this study reports on the identification of 1010 anaerobic bacterial isolates collected between 1999 and 2008 in a major costa rican hospital with the use of two commercial phenotypic systems (rapid 32a and api 20a). approximately 60% of the isolates were gram-positive and, among the 35 species of gram-positive bacteria found, t ...201121722256
major constituents and antimicrobial activity of korean herb acorus calamus.the constituents and antimicrobial activity of the essential oil from acorus calamus were analysed. methyl isoeugenol and cyclohexanone were identified as the major constituents of the essential oil. the essential oil was tested for antimicrobial activity against bacteria and yeast, and has shown strong antibiotic activities against most of the tested microbes, except escherichia coli. the hexane extract has shown a similar pattern of antimicrobial activity as the essential oil. methyl isoeugeno ...201121707379
complete genome sequence of propionibacterium acnes type ib strain 6609.propionibacterium acnes is an anaerobic gram-positive bacterium that forms part of the normal human cutaneous microbiota and is thought to play a central role in acne vulgaris, a chronic inflammatory disease of the pilosebaceous unit (i. kurokawa et al., exp. dermatol. 18:821-832, 2009). here we present the whole genome sequence of p. acnes type ib strain 6609, which was recovered from a skin sample from a woman with no recorded acne history and is thus considered a nonpathogenic strain (i. nagy ...201121705602
scientific summary of the 3rd international symposium on propionibacteria and bifidobacteria: dairy and probiotic applications. 201121705103
3rd international symposium on propionibacteria and bifidobacteria: dairy and probiotic applications, oviedo 1-4 june 2010. 201121705102
treating bugs with bugs: the role of probiotics as adjunctive therapy for helicobacter pylori.to review the literature on the role of probiotics as adjunctive therapy in the treatment of helicobacter pylori infections.201121693698
in vitro inactivation of endodontic pathogens with nd:yag and er:yag lasers.both nd:yag and er:yag lasers have been suggested as root canal disinfection aids. the aim of this in vitro study is to compare both wavelengths in terms of irradiation dose required for microbial inactivation, to quantify these irradiation doses and to investigate the influence of certain (laser) parameters on the antimicrobial efficacy. agar plates containing a uniform layer of enterococcus faecalis, candida albicans or propionibacterium acnes were mounted perpendicularly underneath the laser ...201121691826
tyrosinase activity of greyia flanaganii (bolus) constituents.hyper-pigmentation of the skin is a common problem that is prevalent in middle aged and elderly people. it is caused by over production of melanin. tyrosinase is known to be the key enzyme in melanin production. ethanolic extract of greyia flanaganii leaves showed significant (p<0.05) antityrosinase activity exhibiting the ic(50) of 32.62++g/ml. the total extract was further investigated for its toxicity and effect on melanin production by melanocytes cells, and showed significant inhibition (p< ...201121680165
burden of emerging anaerobes in the maldi-tof and 16s rrna gene sequencing era.the isolation of anaerobes from patients has declined in recent years, whereas their detection by molecular techniques has increased. in the present work, we analyzed the application of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (maldi-tof ms) and 16s rrna gene sequencing to routine identification of anaerobes in clinical microbiology laboratory. we identified 544 isolates of 79 species by routine culture from deep samples in our hospital. maldi-tof ms allowed i ...201121672636
deep wound infection following pediatric scoliosis surgery: incidence and analysis of risk factors.deep wound infection after spinal surgery is a severe complication that often requires prolonged medical and surgical management. it can compromise the outcome of the deformity correction, especially in patients requiring surgical intervention with subsequent removal of implants. ascertaining the incidence and risk factors leading to infection may help to prevent this problem.201121658334
pathogenesis of acne vulgaris: what's new, what's interesting and what may be clinically relevant.acne vulgaris is the most common skin disorder seen in dermatology and primary care offices today with significant associated morbidity. the pathogenesis of acne is complex and multifactorial, and there continues to be an influx of new information to increase our understanding of this chronic disease. recent advances in acne pathogenesis will be discussed, including theories regarding the sequence of events in acne formation, the functions of p. acnes, tlr involvement and role of the sebaceous g ...201121637898
sterility of posterior elements of the spine in posterior correction surgery.abstract: study design. prospective clinical series.objective. to investigate the sterility of the posterior elements of the spine during posterior correction surgery.summary of background data: bacterial growth in the operating field is considered one of the causes of surgical-site infection.methods: eighty consecutive patients (mean age 19.5 years) who underwent posterior correction surgery for spinal deformities were included in the study. during surgery, specimens for bacterial culture were ...201121629158
nickel allergy-promoting effects of microbial or inflammatory substances at the sensitization step in mice.microbial components stimulate innate immunity via toll-like receptors (tlrs), nucleotide-binding oligomerization domain (nod)-like receptors (nlrs), and/or il-1. we recently reported that in mice, escherichia coli lipopolysaccharide (lps, tlr4-ligand) promotes allergic responses to nickel (ni) at both the sensitization and elicitation steps. here, we examined in mice the effects of administering other microbial or inflammatory materials at the ni-sensitization step. a mixture of 1mm nicl(2) and ...201121621645
new insights into physiology and metabolism of propionibacterium freudenreichii.dairy propionibacteria are actinobacteria, mainly isolated from dairy environments. propionibacterium freudenreichii has been used for a long time as a ripening culture in swiss-type cheese manufacture, and is more and more considered for its potent probiotic effects. this review summarises the knowledge on the main p. freudenreichii pathways and the main features explaining its hardiness, and focuses on recent advances concerning its applications as a cheese ripening agent and as a probiotic fo ...201121620505
a descriptive study of bacterial load of full-thickness surgical wounds in dermatologic surgery.background surgical site infections (ssis) after dermatologic surgery cause pain, prolong healing, result in unaesthetic complications, and lead to excessive use of antibiotics. the pathogenesis of wound infections is complex and is dependent on bacterial load and diversity, among several factors. objective to investigate bacterial dynamics at dermatosurgical sites at different time intervals and assess the correlation with postoperative outcomes and to examine different endo- and exogenous fact ...201121615603
efficacy of preoperative home use of 2% chlorhexidine gluconate cloth before shoulder surgery.hypothesis: deep infection after shoulder surgery is a rare but devastating problem. this study tested the hypothesis that the home application of a 2% chlorhexidine gluconate cloth before shoulder surgery would be more efficacious than a standard shower of soap and water at decreasing the preoperative cutaneous levels of pathogenic bacteria on the shoulder. materials and methods: this randomized, prospective study evaluated 100 consecutive patients undergoing shoulder surgery. patients were ran ...201121612945
in-vivo effectiveness of adapalene 0.1%/benzoyl peroxide 2.5% gel on antibiotic-sensitive and resistant propionibacterium acnes.background: a gel combination treatment containing a retinoid (adapalene 0.1%) and an antimicrobial (benzoyl peroxide 2.5%) has been shown to be an effective treatment for acne vulgaris, addressing three of the four pathogenic factors (hyperkeratinization, propionibacterium acnes proliferation, inflammation) without contributing to the incidence of propionibacterium acnes antibiotic resistance as neither the retinoid nor benzoyl peroxide creates selective pressure for resistance. objective: to e ...201121607190
detection of nine microorganisms from the initial carious root lesions using a taqman-based real-time pcr.oral diseases (2011) objective:  the purpose of this study was to quantify nine selected cariogenic bacteria in plaque from sound root surfaces and initial carious root lesions using taqman pcr and to analyse a putative dependence on the kind of initial periodontal treatment. material and methods:  fifty-four subjects with generalized chronic periodontitis were randomly allocated to one of the following initial periodontal therapies: full-mouth disinfection, full-mouth scaling and root planing o ...201121605286
acne analysis, grading and computational assessment methods: an overview.introduction: this paper presents a comprehensive review of acne grading and measurement. acne is a chronic disorder of the pilosebaceous units, with excess sebum production, follicular epidermal hyperproliferation, inflammation and propionibacterium acnes activity. most patients are affected with acne vulgaris, which is the prevalent type of acne. acne vulgaris consists of comedones (whitehead and blackhead), papules, pustules, nodules and cysts. objectives: to review and identify the issues fo ...201121605170
propionibacterium acnes infection of the elbow. 201121602062
microbiology specimens obtained at the time of surgical lung biopsy for interstitial lung disease: clinical yield and cost analysis.objectives: in efforts to obtain complete results, current practice in surgical lung biopsy (lb) for interstitial lung disease (ild) recommends sending lung tissue samples for bacterial, mycobacterial, fungal, and viral cultures. this study assesses the value of this practice by evaluating the microbiology findings obtained from lb for ild and their associated costs. methods: a total of 296 consecutive patients (140 women, 156 men, median age=61 years) underwent lb for ild from 2002 to 2009. all ...201121601471
prevention of liver-tumor colonization by combined immunomodulation and liver lectin blocking.the protective effect of combined treatment (immunomodulation with propionibacterium avidum kp-40; liver lectin blocking by d-galactose administration) on the liver colonization of raw 117-h10 lymphosarcoma was investigated in balb/c-mice. both, immunomodulation with p. avidum kp-40 as well as liver lectin blocking by d-galactose treatment significantly decreased the number of liver tumor colonies in this experimental model. however, the combination of p. avidum kp-40 and d-galactose obviously p ...199521597707
contained rupture of an inflammatory abdominal aortic aneurysm into the iliopsoas muscle : report of a case.a 72-year-old man with a history of old myocardial infarction was admitted to our hospital for surgical treatment of a ruptured abdominal aortic aneurysm. his hemodynamics was stable. he had left lumbar pain on moving his left leg and constipation for ten days without abdominal pain and high fever. elevation of fat density around the aneurysm and ureter involvement were noted on the computed tomography. these characteristic image findings indicated inflammatory aortic aneurysm. during operation, ...201121597420
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