Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| atypical bacterial pneumonia in the hiv-infected population. | human immunodeficiency virus (hiv)-infected individuals are more susceptible to respiratory tract infections by other infectious agents (viruses, bacteria, parasites, and fungi) as their disease progresses to acquired immunodeficiency syndrome. despite effective antiretroviral therapy, bacterial pneumonia (the most frequently occurring hiv-associated pulmonary illness) remains a common cause of morbidity and mortality in the hiv-infected population. over the last few decades, studies have looked ... | 2017 | 28856082 |
| coxiella burnetii immunogenic proteins as a basis for new q fever diagnostic and vaccine development. | coxiella burnetii is the etiological agent of the zoonosis q fever, which can cause an acute or a chronic, life-threatening disease in humans. it presents a highly stable cell form, which persists in the environment and is transmitted via contaminated aerosols. ruminants are considered as the main reservoir for human infections but are usually asymptomatic. subclinical infection in these animals and the occurrence of serologically negative shedders hamper the identification of infected animals w ... | 2017 | 28854806 |
| two mice models for transferability of zoonotic bacteria via tick vector. | spotted fever and typhus-related diseases caused by rickettsiae, lyme borreliosis induced by spirochetes from borrelia burgdorferii sensu lato complex, and q fever evoked by coxiella burnetii, are important zoonoses occurring worldwide. in order to study the pathogenesis of these infections, the efficacy of vaccines from the perspective of protection against the pathogens, pathogen - pathogen interactions during co-infections or pathogen-vector-host interrelationship, a suitable animal model sho ... | 2017 | 28854805 |
| seroprevalence of coxiella burnetii among domestic ruminants and horses in poland. | coxiella burnetii is the causative agent of q fever. the cases of the disease are recorded in various species, including domestic animals. the aim of this investigation was to estimate the seroprevalence of c. burnetii in ruminants including cattle, sheep, goats, and horses. totally, 2082 serum samples from 936 goats, 933 cattle, 89 sheep, and 124 horses, including various horse breeds, were tested by elisa or complement fixation test. the examination revealed that polish horses are seronegative ... | 2017 | 28854804 |
| protein composition of the phase i coxiella burnetii soluble antigen prepared by extraction with trichloroacetic acid. | q fever is a highly infectious, widespread airborne zoonosis caused by coxiella burnetii bacterium. humans usually acquire the disease by inhalation of contaminated aerosol produced by infected livestock. vaccination is the most practical way for prevention and control of the disease in the exposed population. in this work, we reviewed the most important q-fever outbreaks in slovakia as well as the progress in vaccine development. one of them represents a soluble antigen complex produced by extr ... | 2017 | 28854803 |
| workshop on q fever. | no abstract keywords: no keywords. | 2017 | 28854800 |
| genome plasticity and polymorphisms in critical genes correlate with increased virulence of dutch outbreak-related coxiella burnetii strains. | coxiella burnetii is an obligate intracellular bacterium and the etiological agent of q fever. during 2007-2010 the largest q fever outbreak ever reported occurred in the netherlands. it is anticipated that strains from this outbreak demonstrated an increased zoonotic potential as more than 40,000 individuals were assumed to be infected. the acquisition of novel genetic factors by these c. burnetii outbreak strains, such as virulence-related genes, has frequently been proposed and discussed, but ... | 2017 | 28848533 |
| herd-level prevalence of selected endemic infectious diseases of dairy cows in great britain. | to implement appropriate and effective disease control programs at the national level, up-to-date and unbiased information on disease frequency is needed. the aim of this study was to estimate the prevalence of selected endemic infectious diseases in the population of dairy herds in great britain. bulk milk tank (bmt) samples from 225 randomly selected dairy farms, stratified by region and herd size, were tested for antibodies against bovine viral diarrhea virus (bvdv), bovine herpesvirus type 1 ... | 2017 | 28843682 |
| case report: coxiella burnetii vascular infection and lymphoma in the netherlands. | non-hodgkin lymphoma has been linked to infection with coxiella burnetii, potentially through overproduction of il-10 during infection with c. burnetii. | 2017 | 28840502 |
| [was the q fever outbreak in the netherlands surprising?] | the world's largest outbreak of q fever swept the netherlands between 2007 and 2010. the disease seemed to take us by surprise. thousands of people fell ill, dozens of people died and patients continue to suffer from chronic q fever even today. eventually, tens of thousands of pregnant dairy goats were killed to prevent the causative agent of q fever, coxiella burnetii, to spread. the outbreak and its consequences still resonate in court cases, regional politics and reports by the national ombud ... | 2017 | 28831939 |
| a case of q fever with erythema nodosum. | acute q fever is asymptomatic in 60% of the patients, while the reminder may present with fever, pneumoniae, and hepatitis. skin manifestations are uncommon including transient punctiform rashes, purpuric, or maculopapular eruptions. erythema nodosum have seldom been reported. | 2017 | 28819912 |
| epidemiologic study of bacteria zoonotic diseases in south dakota: 2010-2014. | although the burden of infectious diseases has decreased dramatically due to advances in health care, disease prevention and numerous public health efforts and innovations, zoonotic diseases continue to pose a problem in terms of both existing and emerging diseases. these risks are of particular concern in rural areas, in which there is more contact with animals for occupational and recreational purposes. as a rural and agricultural state, south dakota has a large percentage of its population at ... | 2017 | 28813761 |
| vector-borne and zoonotic diseases of dogs in north-west new south wales and the northern territory, australia. | vector-borne diseases of dogs in australian aboriginal communities are relatively unexplored. these dogs represent a unique group with variable ecto- and endo-parasitic burdens, nutritional stresses and a general lack of veterinary intervention. we investigated haemoprotozoal and bacterial pathogen prevalences in relation to erythrocyte and platelet numbers in dogs from north-west new south wales (n-w nsw) and the northern territory (nt; central australia). | 2017 | 28810870 |
| a case of silent q fever endocarditis. | q fever endocarditis is a rare, culture negative endocarditis caused by coxiella burnetii, a spore-forming gram negative coccobacillus. presenting symptoms can be very non-specific; thus, diagnosis may be delayed. we present a case of a 65-year-old male patient with history of aortic aneurysm who complained of chronic fatigue. he was found to have aortic valve vegetation on routine echocardiography. q fever endocarditis was diagnosed based on elevated q fever serology; there was absence of fever ... | 2016 | 28810106 |
| use of axenic media to determine antibiotic efficacy against coxiella burnetii. | the traditional methods of measuring minimum inhibitory concentration (mic) of antibiotics against coxiella burnetii are time consuming and technically difficult. the discovery of axenic media for c. burnetii culture provided an opportunity to determine the feasibility of using both broth dilution and an antimicrobial gradient method (e-test) as a convenient method of measuring mics. the mic for a range of antibiotics that have proven or potential use in the treatment of q-fever, namely doxycycl ... | 2017 | 28802854 |
| quantitative dextran trafficking to the coxiella burnetii parasitophorous vacuole. | the gram-negative bacterium coxiella burnetii causes human q fever, a disease characterized by a debilitating flu-like illness in acute cases and endocarditis in chronic patients. an obligate intracellular pathogen, coxiella burnetii survives within a large, lysosome-like vacuole inside the host cell. a unique feature of the coxiella parasitophorous vacuole (pv) is high levels of fusion with the host endocytic pathway, with pv-endosome fusion critical for coxiella survival within the host cell. ... | 2017 | 28800156 |
| cxcl9, a promising biomarker in the diagnosis of chronic q fever. | in the aftermath of the largest q fever outbreak in the world, diagnosing the potentially lethal complication chronic q fever remains challenging. pcr, coxiella burnetii igg phase i antibodies, crp and (18)f-fdg-pet/ct scan are used for diagnosis and monitoring in clinical practice. we aimed to identify and test biomarkers in order to improve discriminative power of the diagnostic tests and monitoring of chronic q fever. | 2017 | 28793883 |
| diagnosis of coccidioidomycosis in a non-endemic area: inference of the probable geographic area of an infection. | coccidioidomycosis is one of the most important endemic mycoses in northern mexico. however, diagnosing this disease can be challenging, particularly in patients who do not reside in endemic areas. | 2017 | 28784311 |
| low antibodies titer and serological cross-reaction between coxiella burnetii and legionella pneumophila challenge the diagnosis of mediastinitis, an emerging q fever clinical entity. | coxiella burnetii is an intracellular and fastidious bacterium responsible of acute and persistent q fever infection. endocarditis and vascular infections are the most common serious complications of acute q fever. | 2017 | 28779434 |
| detection of coxiella burnetii dna in peridomestic and wild animals and ticks in an endemic region (canary islands, spain). | coxiella burnetii, the etiological agent of human q fever, can infect mammals, birds, and arthropods. the canary islands (spain) are considered an endemic territory, with a high prevalence in both humans and livestock. nonetheless, there is no epidemiological information about the wild and peridomestic cycles of c. burnetii. tissue samples from rodents on farms (100) and wild rabbits (129) were collected and assessed by pcr to detect c. burnetii dna. in parallel, ticks were also collected from v ... | 2017 | 28759337 |
| the seroprevalence of coxiella burnetii in erzincan, turkey: identification of the risk factors and their relationship with geographical features. | coxiella burnetii (c. burnetii) bacterium, the causative agent of q fever has regained importance due to the increasing cases of infections and outbreaks. a cross-sectional descriptive study was conducted to investigate the seroprevalence of c. burnetii in human populations of erzincan province located in the eastern turkey, identify the risk factors, and to explore the relationship between geographical features. | 2017 | 28748837 |
| molecular and maldi-tof identification of ticks and tick-associated bacteria in mali. | ticks are considered the second vector of human and animal diseases after mosquitoes. therefore, identification of ticks and associated pathogens is an important step in the management of these vectors. in recent years, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (maldi-tof ms) has been reported as a promising method for the identification of arthropods including ticks. the objective of this study was to improve the conditions for the preparation of tick samples ... | 2017 | 28742123 |
| q fever prosthetic joint infection. | coxiella burnetii is the causative pathogen of the zoonotic infection q fever. most patients with q fever experience a non-specific febrile illness, hepatitis or pneumonia. q fever has recently been described as a cause of prosthetic joint septic arthritis, but remains very uncommonly reported. we present a case of q fever prosthetic joint septic arthritis that has responded to a combination of two-stage surgical exchange and prolonged medical treatment with doxycycline and hydroxychloroquine. | 2017 | 28739619 |
| ecohealth research in africa: where from-where to? | epidemiological mapping and risk profiling build on the idea that diseases are tied to social-ecological systems that govern the distribution and abundance of transmissible pathogens, vectors and hosts. this is the heart of the emerging field of ecohealth, which examines how biological, cultural, demographic, economic, physical, political and social environments change can affect the health and wellbeing of humans, animals and ecosystems and the services they provide. this paper is an overview o ... | 2017 | 28733024 |
| thrombosis and antiphospholipid antibody syndrome during acute q fever: a cross-sectional study. | q fever is a neglected and potentially fatal disease. during acute q fever, antiphospholipid antibodies are very prevalent and have been associated with fever, thrombocytopenia, acquired heart valve disease, and progression to chronic endocarditis. however, thrombosis, the main clinical criterion of the 2006 updated classification of the antiphospholipid syndrome, has not been assessed in this context. to test whether thrombosis is associated with antiphospholipid antibodies and whether the crit ... | 2017 | 28723794 |
| epidemiology of spotted fever group rickettsioses and acute undifferentiated febrile illness in villeta, colombia. | etiology of acute undifferentiated febrile syndrome (aufs) is often unknown, leading to inaccurate diagnosis and treatment. villeta town has been identified as an endemic area for spotted fever group (sfg) rickettsioses but little is known about possible amplifier hosts and other rickettsia species different from rickettsia rickettsii. besides, few studies have approached other aufs etiologies in the region. we investigated the role of dengue, leptospirosis, rickettsioses, human anaplasmosis, an ... | 2017 | 28722568 |
| coxiellosis in domestic livestock of puducherry and tamil nadu: detection of coxiella burnetii dna by polymerase chain reaction in slaughtered ruminants. | in the course of our indian council of medical research project on coxiellosis in puducherry and tamil nadu, 5.64% goat, 1.85% sheep, 1.06% buffaloes, and 0.97% cattle were positive for coxiella burnetii antibodies by enzyme linked immunosorbent assay kit (idexx, liebefeld, switzerland). in this preliminary study, we have proceeded to look for c. burnetii dna in those antibody positive specimens employing an imported commercial c. burnetii polymerase chain reaction (pcr) kit. | 2017 | 28717320 |
| the clinical challenge of chronic q fever with isolated liver involvement. | chronic q fever is defined as an infection by coxiella burnetii (c. burnetii) that lasts for six months or more. it occurs in 1-5% of individuals infected with this agent and develops over a period of months to years after the acute infection. cases of hepatic involvement are rare. | 2017 | 28715899 |
| legionella and coxiella effectors: strength in diversity and activity. | legionella pneumophila and coxiella burnetii are two evolutionarily related intracellular pathogens that use the dot/icm type iv secretion system to translocate effectors into host cells. these effectors are essential for the establishment of membrane-bound compartments known as replication vacuoles, which enable the survival and replication of bacteria inside host cells. the effectors interfere with diverse signalling pathways to co-opt host processes, such as vesicle trafficking, ubiquitylatio ... | 2017 | 28713154 |
| biopsychosocial risk factors of persistent fatigue after acute infection: a systematic review to inform interventions. | fatigue is a prevalent and debilitating symptom, preceded by an acute infectious episode in some patients. this systematic review aimed to identify risk factors for the development of persistent fatigue after an acute infection, to develop an evidence-based working model of post-infectious fatigue. | 2017 | 28712416 |
| characteristics of scrub typhus, murine typhus, and q fever among elderly patients: prolonged prothrombin time as a predictor for severity. | the clinical manifestations of scrub typhus, murine typhus and acute q fever in the elderly are not clear. | 2017 | 28709838 |
| multiple substrate usage of coxiella burnetii to feed a bipartite metabolic network. | the human pathogen coxiella burnetii causes q-fever and is classified as a category b bio-weapon. exploiting the development of the axenic growth medium accm-2, we have now used (13)c-labeling experiments and isotopolog profiling to investigate the highly diverse metabolic network of c. burnetii. to this aim, c. burnetii rsa 439 nmii was cultured in accm-2 containing 5 mm of either [u-(13)c3]serine, [u-(13)c6]glucose, or [u-(13)c3]glycerol until the late-logarithmic phase. gc/ms-based isotopolog ... | 2017 | 28706879 |
| dot map cartograms for detection of infectious disease outbreaks: an application to q fever, the netherlands and pertussis, germany. | geographical mapping of infectious diseases is an important tool for detecting and characterising outbreaks. two common mapping methods, dot maps and incidence maps, have important shortcomings. the former does not represent population density and can compromise case privacy, and the latter relies on pre-defined administrative boundaries. we propose a method that overcomes these limitations: dot map cartograms. these create a point pattern of cases while reshaping spatial units, such that spatia ... | 2017 | 28681721 |
| molecular detection of coxiella burnetii from the formalin-fixed tissues of q fever patients with acute hepatitis. | serologic diagnosis is one of the most widely used diagnostic methods for q fever, but the window period in antibody response of 2 to 3 weeks after symptom onset results in significant diagnostic delay. we investigated the diagnostic utility of q fever pcr from formalin-fixed liver tissues in q fever patients with acute hepatitis. | 2017 | 28672014 |
| microbiological zoonotic emerging risks, transmitted between livestock animals and humans (2007-2015). | as part of the emerging risk identification (eri) activities of the european food safety authority (efsa), a literature search was conducted to identify the microbiological agents transmitted between livestock animals and humans that have been suggested as having emerged between 2007 and 2015 in peer-reviewed scientific literature published during the same period (2007-2015). according to the criteria set, the search identified seven such zoonotic agents, namely west nile fever virus, rift valle ... | 2017 | 28670863 |
| a human time dose response model for q fever. | the causative agent of q fever, coxiella burnetii, has the potential to be developed for use in biological warfare and it is classified as a bioterrorism threat agent by the centers for disease control and prevention (cdc) and as a category b select agent by the national institute of allergy and infectious diseases (niaid). in this paper we focus on the in-host properties that arise when an individual inhales a dose of c. burnetii and establish a human time-dose response model. we also propagate ... | 2017 | 28666604 |
| an integrated study of human and animal infectious disease in the lake victoria crescent small-holder crop-livestock production system, kenya. | the neglected zoonotic diseases (nzd) are an understudied group that are a major cause of illness throughout the developing world. in general, little is known about the prevalence and burden of nzds in affected communities, particularly in relation to other infectious diseases with which they are often co-endemic. we describe the design and descriptive epidemiological outputs from an integrated study of human and animal zoonotic and non-zoonotic disease in a rural farming community in western ke ... | 2017 | 28666412 |
| laboratory diagnosis of infective endocarditis. | infective endocarditis is life-threatening; identification of the underlying etiology informs optimized individual patient management. changing epidemiology, advances in blood culture techniques, and new diagnostics guide the application of laboratory testing for diagnosis of endocarditis. blood cultures remain the standard test for microbial diagnosis, with directed serological testing (i.e., q fever serology, bartonella serology) in culture-negative cases. histopathology and molecular diagnost ... | 2017 | 28659319 |
| simultaneous uhplc-uv analysis of hydroxychloroquine, minocycline and doxycycline from serum samples for the therapeutic drug monitoring of q fever and whipple's disease. | a fast uhplc-uv method was developed for the simultaneous analysis of hydroxychloroquine, minocycline and doxycycline drugs from 100μl of human serum samples. serum samples were extracted by liquid-liquid extraction and injected into a phenyl hexyl reverse phase column. compounds were separated using a mobile phase linear gradient and monitored by uv detection at 343nm. chloroquine and oxytetracycline were used as internal standards. lower and upper limits of quantifications, as well as the othe ... | 2017 | 28622620 |
| physicochemical and nutritional requirements for axenic replication suggest physiological basis for coxiella burnetii niche restriction. | bacterial obligate intracellular parasites are clinically significant animal and human pathogens. central to the biology of these organisms is their level of adaptation to intracellular replication niches associated with physicochemical and nutritional constraints. while most bacterial pathogens can adapt to a wide range of environments, severe niche restriction-an inability to thrive in diverse environments-is a hallmark of bacterial obligate intracellular parasites. herein the physicochemical ... | 2017 | 28620582 |
| farmers' knowledge of q fever and prevention approaches in new south wales. | to identify what new south wales (nsw) farmers know about q fever to inform preventive approaches. | 2017 | 28618042 |
| q fever in an endemic region of north queensland, australia: a 10 year review. | q fever is a zoonotic infection caused by coxiella burnetii. endemic q fever has long been recognised in north queensland, with north queensland previously acknowledged to have the highest rate of notification in australia. in this retrospective study, we reviewed the demographics and exposure of patients diagnosed with q fever in an endemic region of north queensland, to identify trends and exposure factors for the acquisition of q fever. | 2017 | 28616504 |
| human q fever incidence is associated to spatiotemporal environmental conditions. | airborne pathogenic transmission from sources to humans is characterised by atmospheric dispersion and influence of environmental conditions on deposition and reaerosolisation. we applied a one health approach using human, veterinary and environmental data regarding the 2009 epidemic in the netherlands, and investigated whether observed human q fever incidence rates were correlated to environmental risk factors. we identified 158 putative sources (dairy goat and sheep farms) and included 2339 hu ... | 2016 | 28616479 |
| [purification of the recombinant com1 and adaa of coxiella burnetii and identification of the antigenicity]. | objective to express and purify two kinds of antigens of coxiella burnetii (c. burnetii), the main outer membrane protein com1 and the acute disease antigen a (adaa), in prokaryotic expression system and to validate the two recombinant antigens by mass spectrometry and identify their antigenicity. methods the gene sequences encoding com1 and adaa were separately synthesized and constructed into the prokaryotic expression vector pet-20b(+). the constructed vectors were transformed into e.coli bl2 ... | 2017 | 28615092 |
| a case of q fever after liver transplantation. | coxiella burnetii, the causative agent of q fever, is a zoonosis that causes both acute and chronic disease in humans. few cases have been reported in solid organ transplant recipients, and this case highlights the need to include q fever in the differential diagnosis for fever of unknown origin in solid organ transplant hosts. | 2017 | 28613410 |
| efficacy of paromomycin-chloroquine combination therapy in experimental cutaneous leishmaniasis. | the 4-aminoquinoline chloroquine (cq) is clinically used in combination with doxycycline to cure chronic q fever, as it enhances the activity of the antibiotic against the causative bacterium coxiella burnetii residing within macrophage phagolysosomes. as there is a similar cellular host-pathogen biology for leishmania parasites, this study aimed to determine whether such an approach could also be the basis for a new, improved treatment for cutaneous leishmaniasis (cl). we have evaluated the in ... | 2017 | 28607026 |
| seroreactivity to q fever among slaughterhouse workers in south korea. | q fever is a zoonotic disease that occurs worldwide; however, little is known about its prevalence in south korea. we attempted to determine the prevalence of q fever seroreactivity among korean slaughterhouse workers and the risk factors for seroreactivity according to the type of work. | 2017 | 28605884 |
| vaginal self-sampling as a diagnosis tool in low-income countries and potential applications for exploring the infectious causes of miscarriage. | gynecological health is a challenge in low-income countries. personal opposition to perineal examination has been overcome by the use of vaginal self-sampling. here, we review the use of this procedure notably in low-income countries and the main infectious causes of miscarriage. vaginal self-sampling was mainly used for human papillomavirus detection but also to detect microorganisms causing sexually transmitted infections or bacterial vaginosis. 58 studies have been performed in low-resource c ... | 2017 | 28604063 |
| whole-genome sequence of coxiella burnetii nine mile rsa439 (phase ii, clone 4), a laboratory workhorse strain. | here, we report the whole-genome sequence of coxiella burnetii nine mile rsa439 (phase ii, clone 4), a laboratory strain used extensively to investigate the biology of this intracellular bacterial pathogen. the genome consists of a 1.97-mb chromosome and a 37.32-kb plasmid. | 2017 | 28596399 |
| molecular survey of coxiella burnetii in wildlife and ticks at wildlife-livestock interfaces in kenya. | coxiella burnetii is the causative agent of q fever, a zoonotic disease of public health importance. the role of wildlife and their ticks in the epidemiology of c. burnetii in kenya is unknown. this study analysed the occurrence and prevalence of the pathogen in wildlife and their ticks at two unique wildlife-livestock interfaces of laikipia and maasai mara national reserve (mmnr) with the aim to determine the potential risk of transmission to livestock and humans. blood from 79 and 73 animals i ... | 2017 | 28593481 |
| one health contributions towards more effective and equitable approaches to health in low- and middle-income countries. | emerging zoonoses with pandemic potential are a stated priority for the global health security agenda, but endemic zoonoses also have a major societal impact in low-resource settings. although many endemic zoonoses can be treated, timely diagnosis and appropriate clinical management of human cases is often challenging. preventive 'one health' interventions, e.g. interventions in animal populations that generate human health benefits, may provide a useful approach to overcoming some of these chal ... | 2017 | 28584176 |
| occurrence of <i>coxiella burnetii</i>, <i>ehrlichia canis</i>, <i>rickettsia</i> species and <i>anaplasma phagocytophilum</i>-like bacterium in ticks collected from dogs and cats in south africa. | ticks are major vectors of arthropod-borne infections and transmit a wide variety of zoonotic pathogens. this study was conducted mainly to determine the occurrence of canine tick-borne bacterial and rickettsial pathogens especially those with zoonotic potential. we examined 276 rhipicephalus sanguineus, 38 haemaphysalis elliptica and 4 amblyomma hebraeum ticks from 90 dogs and 4 cats from the free state, kwazulu-natal, north west and mpumalanga provinces. dna of coxiella burnetii (41%), ehrlich ... | 2017 | 28582983 |
| detection of coxiella burnetii in urban river water. | previous molecular-based studies have identified microorganisms of zoonotic and human nature in surface waters. contaminated water can lead to human health issues, and the detection of pathogenic microorganisms is a valuable tool for the prevention of their spread. water samples were taken from the river tiber in and out of the city of rome. genetic analysis of the sequences obtained showed the presence of coxiella burnetii in both the analyzed sites. blast analysis showed that two sequences wer ... | 2017 | 28581349 |
| acute granulomatous hepatitis in an immunosuppressed patient secondary to q fever. | 2017 | 28549166 | |
| the value of (18)f-fdg-pet/ct in diagnosis and during follow-up in 273 patients with chronic q fever. | in 1-5% of all acute q fever infections, chronic q fever develops, mostly manifesting as endocarditis, infected aneurysms, or infected vascular prostheses. in this study, we investigated the diagnostic value of (18)f-fluorodeoxyglucose positron emission tomography/computed tomography ((18)f-fdg-pet/ct) in chronic q fever at diagnosis and during follow-up. methods: all dutch adult patients suspected of chronic q fever who were diagnosed since 2007 were retrospectively included until march 2015 wh ... | 2017 | 28546336 |
| horizontally acquired biosynthesis genes boost coxiella burnetii's physiology. | coxiella burnetii, the etiologic agent of acute q fever and chronic endocarditis, has a unique biphasic life cycle, which includes a metabolically active intracellular form that occupies a large lysosome-derived acidic vacuole. c. burnetii is the only bacterium known to thrive within such an hostile intracellular niche, and this ability is fundamental to its pathogenicity; however, very little is known about genes that facilitate coxiella's intracellular growth. recent studies indicate that c. b ... | 2017 | 28540258 |
| candidatus neoehrlichia mikurensis and borrelia burgdorferi sensu lato detected in the blood of norwegian patients with erythema migrans. | the most common tick-borne human disease in norway is lyme borreliosis. ticks in norway also harbour less known disease-causing agents such as candidatus neoehrlichia mikurensis, borrelia miyamotoi and rickettsia helvetica. however, human infections caused by these pathogens have never been described in norway. the main aims of the study were to evaluate the contribution of several tick-borne bacterial agents, other than borrelia burgdorferi sensu lato, to zoonotic diseases in norway and to dete ... | 2017 | 28539197 |
| getting "inside" type i ifns: type i ifns in intracellular bacterial infections. | type i interferons represent a unique and complex group of cytokines, serving many purposes during innate and adaptive immunity. discovered in the context of viral infections, type i ifns are now known to have myriad effects in infectious and autoimmune disease settings. type i ifn signaling during bacterial infections is dependent on many factors including whether the infecting bacterium is intracellular or extracellular, as different signaling pathways are activated. as such, the repercussions ... | 2017 | 28529959 |
| q fever: confusion between chronic infection and chronic fatigue. | 2017 | 28520862 | |
| are brucellosis, q fever and melioidosis potential causes of febrile illness in madagascar? | brucellosis, q fever and melioidosis are zoonoses, which can lead to pyrexia. these diseases are often under-ascertained and underreported because of their unspecific clinical signs and symptoms, insufficient awareness by physicians and public health officers and limited diagnostic capabilities, especially in low-resource countries. therefore, the presence of brucella spp., coxiella burnetii and burkholderia pseudomallei was investigated in malagasy patients exhibiting febrile illness. in additi ... | 2017 | 28502643 |
| molecular detection of tick-borne pathogens in wild red foxes (vulpes vulpes) from central italy. | spleen samples from 153 red foxes, shot during regular hunting season in the province of pisa (central italy), were examined to detect dna of anaplasma phagocytophilum, ehrlichia canis, coxiella burnetii, francisella tularensis, hepatozoon canis and babesia sp./theileria sp. dna of vector-borne pathogens was detected in 120 (78.43%; 95% ci: 71.06-84.66%) foxes. specifically, 75 (49%; 95% ci: 40.86-57.22%) animals scored pcr-positive per h. canis, 68 (44.44%; 95% ci: 36.42-52.69%) for e. canis, 3 ... | 2017 | 28502642 |
| prevalence of coxiella burnetii in cattle at south korean national breeding stock farms. | this is the first study to evaluate the serologic and molecular prevalence of coxiella burnetii in cattle at national breeding stock farms in south korea. these government farms have well-organized biosecurity and management systems to prevent livestock diseases. of the 736 cattle in this study, 77 tested positive for antibodies against c. burnetii antigens (10.5%, 95% ci: 8.3-12.7) and 11 were positive for a c. burnetti infection on pcr analysis (1.5%, 95% ci: 0.6-2.4). since the 16s rrna seque ... | 2017 | 28493973 |
| alterations of the coxiella burnetii replicative vacuole membrane integrity and interplay with the autophagy pathway. | coxiella burnetii, the etiologic agent of q fever, is a gram-negative obligate intracellular bacterium. it has been previously described that both the endocytic and autophagic pathways contribute to the coxiella replicative vacuole (crv) generation. galectins are β-galactoside-binding lectins that accumulate in the cytosol before being secreted via a non-conventional secretory pathway. it has been shown that galectin-3, -8, -9 monitor bacteria vacuolar rupture and endosomal and lysosomal loss of ... | 2017 | 28484683 |
| the presence of rhipicephalus muhsamae north of the sahara. | the occurrence of male and female rhipicephalus muhsamae feeding on dogs and a horse in upper egypt is described. the morphological identification was verified using partial 16s rrna gene sequences. by applying respective real-time pcrs, no evidence neither for coxiella burnetii nor for spotted-fever rickettsia infections were found in the ticks. | 2017 | 28483409 |
| clinical and genetic features of coxiella burnetii in a patient with an acute febrile illness in korea. | although q fever is an important zoonotic infection with a worldwide distribution, no human isolates of coxiella burnetii have been identified in korea. for the first time, we identified the nucleotide sequence of c. burnetii from a 32-year-old man with an acute febrile illness in korea. diagnosis of acute q fever was confirmed by seroconversion using indirect immunofluorescence antibody assays. phylogenetic analysis demonstrated high sequence similarity (99.6%-100%) with c. burnetii 16s rrna se ... | 2017 | 28480664 |
| [leptospirosis in french guiana and the guiana shield: current knowledge in 2016]. | leptospirosis is a cosmopolitan zoonosis caused by bacteria of the genus leptospira. whether the distribution is worldwide, the hot and humid climate of the tropics is particularly conducive to its expansion. in most french overseas departments and territories, leptospirosis is considered as a public health problem. in french guiana, a french department located in the northeastern part of the amazon rainforest, it is supposed to be rare. the objective of this review was to make an inventory of t ... | 2017 | 28478544 |
| hydroxychloroquine susceptibility determination of coxiella burnetii in human embryonic lung (hel) fibroblast cells. | coxiella burnetii, the causative agent of q fever, survives and replicates in the acidic environment of monocytes/macrophages; hydroxychloroquine, through alkalinisation of the acidic vacuoles, is critical for the management of q fever. in this study, a collection of c. burnetii strains isolated from human samples was tested to evaluate the in vitro minimum inhibitory concentrations (mics) of doxycycline and hydroxychloroquine. serial two-fold dilutions of doxycycline (0.25-8 mg/l) and hydroxych ... | 2017 | 28478211 |
| an evaluation of risk factors for infection with coxiella burnetii in domestic goats. | 2017 | 28463720 | |
| coxiella burnetii (q fever) infection in dairy cattle and associated risk factors in latvia. | the purpose of this study was to describe prevalence and spatial distribution of coxiella burnetii infections in dairy cow sheds in latvia and to investigate risk factors contributing to c. burnetii infections. blood serum samples from abortion cases from 1010 sheds have been tested by elisa for the presence of c. burnetii antibodies and bulk tank milk (btm) samples from 252 sheds have been tested by real time polymerase chain reaction and elisa for the presence of c. burnetii dna and antibodies ... | 2017 | 28462725 |
| approaches for reverse line blot-based detection of microbial pathogens in ixodes ricinus ticks collected in austria and impact of the chosen method. | ticks transmit a large number of pathogens capable of causing human disease. in this study, the pcr-reverse line blot (rlb) method was used to screen for pathogens in a total of 554 ixodes ricinus ticks collected from all provinces of austria. these pathogens belong to the genera borrelia, rickettsiae, anaplasma/ehrlichia (including "candidatus neoehrlichia"), babesia, and coxiella the pathogens with the highest detected prevalence were spirochetes of the borrelia burgdorferisensu lato complex, ... | 2017 | 28455331 |
| coxiella burnetii circulation in a naturally infected flock of sheep: individual follow-up of antibodies in serum and milk. | the control of q fever, a zoonotic disease caused by the coxiella burnetii bacterium, remains a scientific challenge. domestic ruminants are considered the main reservoir, shedding c. burnetii essentially through parturition products during abortion or birth. sheep are particularly frequently associated with human outbreaks, but there are insufficient field data to fully understand disease dynamics and to instigate efficient control measures. a longitudinal follow-up study of a naturally infecte ... | 2017 | 28455328 |
| the coxiella burnetii type ivb secretion system (t4bss) component dota is released/secreted during infection of host cells and during in vitro growth in a t4bss-dependent manner. | coxiella burnetii is a gram-negative intracellular pathogen and is the causative agent of the zoonotic disease q fever. to cause disease, c. burnetii requires a functional type ivb secretion system (t4bss) to transfer effector proteins required for the establishment and maintenance of a membrane-bound parasitophorous vacuole (pv) and further modulation of host cell process. however, it is not clear how the t4bss interacts with the pv membrane since neither a secretion pilus nor an extracellular ... | 2017 | 28449081 |
| host and bacterial factors control susceptibility of drosophila melanogaster to coxiella burnetii infection. | coxiella burnetii is the causative agent of q fever, a zoonotic disease that threatens both human and animal health. due to the paucity of experimental animal models, little is known about how host factors interface with bacterial components and affect pathogenesis. here, we used drosophila melanogaster, in conjunction with the biosafety level 2 (bsl2) nine mile phase ii (nmii) clone 4 strain of c. burnetii, as a model to investigate host and bacterial components implicated in infection. we demo ... | 2017 | 28438980 |
| environmental sampling coupled with real-time pcr and genotyping to investigate the source of a q fever outbreak in a work setting. | a q fever outbreak was declared in february 2016 in a company that manufactures hoists and chains and therefore with no apparent occupational-associated risk. coxiella burnetii infection was diagnosed by serology in eight of the 29 workers of the company; seven of them had fever or flu-like signs and five had pneumonia, one requiring hospitalisation. a further case of c. burnetii pneumonia was diagnosed in a local resident. real-time pcr (rti-pcr) showed a widespread distribution of c. burnetii ... | 2017 | 28434420 |
| updated systematic review: associations between proximity to animal feeding operations and health of individuals in nearby communities. | the objective of this review was to update a systematic review of associations between living near an animal feeding operation (afo) and human health. | 2017 | 28420442 |
| no such thing as chronic q fever. | modern diagnostic methods enable clinicians to look beyond a diagnosis of chronic q fever and discern whether patients instead have persistent focalized coxiella burnetii infection(s). use of these methods and development of criteria to define and treat such infections, especially cardiovascular infections, will improve the prognosis for patients previously thought to have chronic q fever. | 2017 | 28418317 |
| the end of a dogma: the safety of doxycycline use in young children for malaria treatment. | anti-malarial drug resistance to chloroquine and sulfadoxine-pyrimethamine has spread from southeast asia to africa. furthermore, the recent emergence of resistance to artemisinin-based combination therapy (act) in southeast asia highlights the need to identify new anti-malarial drugs. doxycycline is recommended for malaria chemoprophylaxis for travel in endemic areas, or in combination with the use of quinine for malaria treatment when act is unavailable or when the treatment of severe malaria ... | 2017 | 28407772 |
| permissiveness of bovine epithelial cells from lung, intestine, placenta and udder for infection with coxiella burnetii. | ruminants are the main source of human infections with the obligate intracellular bacterium coxiella (c.) burnetii. infected animals shed high numbers of c. burnetii by milk, feces, and birth products. in goats, shedding by the latter route coincides with c. burnetii replication in epithelial (trophoblast) cells of the placenta, which led us to hypothesize that epithelial cells are generally implicated in replication and shedding of c. burnetii. we therefore aimed at analyzing the interactions o ... | 2017 | 28403908 |
| tick-borne infectious diseases in australia. | tick bites in australia can lead to a variety of illnesses in patients. these include infection, allergies, paralysis, autoimmune disease, post-infection fatigue and australian multisystem disorder. rickettsial (rickettsia spp.) infections (queensland tick typhus, flinders island spotted fever and australian spotted fever) and q fever (coxiella burnetii) are the only systemic bacterial infections that are known to be transmitted by tick bites in australia. three species of local ticks transmit b ... | 2017 | 28403767 |
| coxiella burnetii antibody seropositivity is not a risk factor for aids-related non-hodgkin lymphoma. | 2017 | 28396496 | |
| acute q fever in febrile patients in northwestern of iran. | q fever is an endemic disease in different parts of iran. this study aimed to investigate the prevalence of acute q fever disease among at-risk individuals in northwestern iran. | 2017 | 28394892 |
| seroprevalence of q fever among human and animal in iran; a systematic review and meta-analysis. | q fever is a main zoonotic disease around the world. the aim of this meta-analysis was to estimate the overall seroprevalence of coxiella burnetii among human and animal population in iran. | 2017 | 28394889 |
| coxiella burnetii isolates originating from infected cattle induce a more pronounced pro-inflammatory cytokine response compared to isolates from infected goats and sheep. | coxiella burnetii is the causative agent of q fever. although the prevalence of c. burnetii in cattle is much higher than in goats and sheep, infected cattle are rarely associated with human outbreaks. we investigated whether the immune response of humans differs after contact with c. burnetii isolates from different host origins or with different multi-locus variable number of tandem repeat analysis (mlva) genotypes.cytokine responses were measured in human peripheral blood mononuclear cells (p ... | 2017 | 28387835 |
| serological evidence of exposure to zoonotic tick-borne bacteria in pheasants (phasianus colchicus). | previous studies on tick-borne pathogens in the avian population have focused mainly on the detection of the agents in ticks collected from birds, but data about the presence of tick-borne bacteria in these animals are scant. the aim of the presented study was to verify the exposure to some zoonotic tick-borne bacteria, in particular, anaplasma phagocytophilum, borrelia burgdorferi sensu lato, coxiella burnetii, and the rickettsia species of the spotted fever group (sfg), in pheasants (phasianus ... | 2017 | 28378988 |
| prevalence and risk factors for coxiella burnetii seropositivity in small ruminant veterinarians and veterinary students in ontario, canada. | coxiella burnetii is a zoonotic pathogen that causes q fever in humans. serological and questionnaire data on c. burnetii were obtained from 32 small ruminant veterinarians and veterinary students in ontario, canada, in february 2012. overall, 59% of participants were seropositive; advanced stage of career and increased age were associated with seropositivity. | 2017 | 28373734 |
| laboratory approach to the diagnosis of culture-negative infective endocarditis. | blood-culture negative endocarditis (bcne) accounts for up to 35% of all cases of infective endocarditis (ie) and is a serious life-threatening condition with considerable morbidity and mortality. rapid detection and identification of the causative pathogen is essential for timely, directed therapy. blood-culture negative endocarditis presents a diagnostic and therapeutic challenge. causes of bcne are varied including: treatment with antibiotic agents prior to blood culture collection; sub-optim ... | 2017 | 28372886 |
| peripartum dynamics of coxiella burnetii infections in intensively managed dairy goats associated with a q fever outbreak in australia. | coxiella burnetii may cause reproduction disorders in pregnant animals but subclinical infection in other animals. unrecognised disease may delay implementation of control interventions, resulting in transmission of infection to other livestock and to humans. seroreactivity to c. burnetii phase-specific antigens, is routinely used to interpret the course of human q fever. this approach could be similarly useful in identifying new and existing infections in livestock herds to help describe risk f ... | 2017 | 28364833 |
| a study on some reproductive disorders in dromedary camel herds in saudi arabia with special references to uterine infections and abortion. | dromedary camels complaining from conception failure or abortion were investigated and their herders interviewed in al ahsa province, kingdom of saudi arabia (ksa) during 2013 and 2015. the most important reproductive disorder according to the responders is uterine infection (60.2%) followed by obesity (22.3%) then physiological conditions (hormonal disturbances; 7.8%), adhesions (3.9%) and repeat breeders (2.9%). of the camel herders, 78.6% reported previous occurrence of abortion in their herd ... | 2017 | 28364266 |
| livestock-associated risk factors for pneumonia in an area of intensive animal farming in the netherlands. | previous research conducted in 2009 found a significant positive association between pneumonia in humans and living close to goat and poultry farms. however, as this result might have been affected by a large goat-related q fever epidemic, the aim of the current study was to re-evaluate this association, now that the q-fever epidemic had ended. in 2014/15, 2,494 adults (aged 20-72 years) living in a livestock-dense area in the netherlands participated in a medical examination and completed a que ... | 2017 | 28362816 |
| massive dispersal of coxiella burnetii among cattle across the united states. | q-fever is an underreported disease caused by the bacterium coxiella burnetii, which is highly infectious and has the ability to disperse great distances. it is a completely clonal pathogen with low genetic diversity and requires whole-genome analysis to identify discriminating features among closely related isolates. c. burnetii, and in particular one genotype (st20), is commonly found in cow's milk across the entire dairy industry of the usa. this single genotype dominance is suggestive of hos ... | 2016 | 28348863 |
| molecular evidence of rickettsia spp. in ixodid ticks and rodents in suburban, natural and rural habitats in slovakia. | natural foci of tick-borne spotted fever group (sfg) rickettsiae of public health concern have been found in slovakia, but the role of rodents in their circulation is unclear. ticks (ixodes ricinus, ixodes trianguliceps, dermacentor marginatus, dermacentor reticulatus, haemaphysalis concinna and haemaphysalis inermis) and tissues of rodents (apodemus flavicollis, apodemus sylvaticus, myodes glareolus, microtus arvalis, microtus subterraneus and micromys minutus) were examined for the presence of ... | 2017 | 28340608 |
| effectiveness of long-term doxycycline treatment and cognitive-behavioral therapy on fatigue severity in patients with q fever fatigue syndrome (qure study): a randomized controlled trial. | approximately 20% of patients with acute q fever will develop chronic fatigue, referred to as q fever fatigue syndrome (qfs). the objective of this randomized controlled clinical trial was to assess the efficacy of either long-term treatment with doxycycline or cognitive-behavioral therapy (cbt) in reducing fatigue severity in patients with qfs. | 2017 | 28329131 |
| seroprevalence of bartonella species, coxiella burnetii and toxoplasma gondii among patients with hematological malignancies: a pilot study in romania. | patients receiving immunosuppressive cancer treatments in settings where there is a high degree of human-animal interaction may be at increased risk for opportunistic zoonotic infections or reactivation of latent infections. we sought to determine the seroprevalence of selected zoonotic pathogens among patients diagnosed with haematologic malignancies and undergoing chemotherapeutic treatments in romania, where much of the general population lives and/or works in contact with livestock. a conven ... | 2017 | 28328183 |
| first genetic evidence of coxiella burnetii in cases presenting with acute febrile illness, india. | 2017 | 28319680 | |
| review of bacterial and viral zoonotic infections transmitted by dogs. | dogs are a major reservoir for zoonotic infections. dogs transmit several viral and bacterial diseases to humans. zoonotic diseases can be transmitted to human by infected saliva, aerosols, contaminated urine or feces and direct contact with the dog. viral infections such as rabies and norovirus and bacterial infections including pasteurella, salmonella, brucella, yersinia enterocolitica, campylobacter, capnocytophaga, bordetella bronchiseptica, coxiella burnetii, leptospira, staphylococcus inte ... | 2015 | 28316698 |
| knowledge, attitudes and practices towards spotted fever group rickettsioses and q fever in laikipia and maasai mara, kenya. | many factors contribute to misdiagnosis and underreporting of infectious zoonotic diseases in most sub-saharan africa including limited diagnostic capacity and poor knowledge. we assessed the knowledge, practices and attitudes towards spotted fever group rickettsioses (sfgr) and q fever amongst local residents in laikipia and maasai mara in kenya. a semi-structured questionnaire was administered to a total of 101 respondents including 51 pastoralists, 17 human health providers, 28 wildlife secto ... | 2016 | 28299153 |
| live cell therapy as potential risk factor for q fever. | during an outbreak of q fever in germany, we identified an infected sheep flock from which animals were routinely used as a source for life cell therapy (lct), the injection of fetal cells or cell extracts from sheep into humans. q fever developed in 7 lct recipients from canada, germany, and the united states. | 2017 | 28296631 |
| high-content imaging reveals expansion of the endosomal compartment during coxiella burnetii parasitophorous vacuole maturation. | coxiella burnetii is an obligate intracellular pathogen and the causative agent of human q fever. replication of the bacterium within a large parasitophorous vacuole (pv) resembling a host phagolysosome is required for pathogenesis. pv biogenesis is a pathogen driven process that requires engagement of several host cell vesicular trafficking pathways to acquire vacuole components. the goal of this study was to determine if infection by c. burnetii modulates endolysosomal flux to potentially bene ... | 2017 | 28293541 |
| [effects of vaccination against q-fever in lower saxony dairy cattle farms]. | being a notifiable and zoonotic disease, q-fever is coming under increasing focus of epizootic disease control. current studies indicate that the disease is more widespread in germany than the number of notifications suggest. therefore, since 2013, under certain conditions a hardship allowance is granted by the animal diseases fund of lower saxony for the vaccine costs of the basic immunization to support affected farms. material und methods: all farmers, on whose farms clinical signs of q-fever ... | 2017 | 28290594 |
| molecular investigation into the presence of a coxiella sp. in rhipicephalus sanguineus ticks in australia. | q fever is an infectious disease with a global distribution caused by the intracellular bacterium, coxiella burnetii, which has been detected in a large number of tick species worldwide, including the brown dog tick, rhipicephalus sanguineus. recent reports of a high seroprevalance of c. burnetii in australian dogs, along with the identification of additional coxiella species within r. sanguineus ticks, has prompted an investigation into the presence and identification of coxiella species in r. ... | 2017 | 28284601 |