Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| borrelia burgdorferi sensu lato in ixodes longiscutatus ticks from brazilian pampa. | borrelia burgdorferi sensu lato (s.l.) complex includes the agents of lyme disease/borreliosis in north america, europe, and asia, such borrelia burgdorferi sensu stricto, borrelia afzelii, borrelia garinii, borrelia bavariensis, borrelia spielmanii, borrelia bissettiae, and borrelia mayonii. in 2013 b. burgdorferi s.l. was reported for the first time in the neotropical region, from ixodes aragaoi ticks in uruguayan pampa. in addition, from 2011 to 2016, 17 suspected human cases of borreliosis-l ... | 2017 | 28847698 |
| infection of ixodes ricinus by borrelia burgdorferi sensu lato in peri-urban forests of france. | lyme borreliosis is the most common tick-borne disease in the northern hemisphere. in europe, it is transmitted by ixodes ticks that carry bacteria belonging to the borrelia burgdorferi sensu lato complex. the objective of this work was to explore eco-epidemiological factors of lyme borreliosis in peri-urban forests of france (sénart, notre-dame and rambouillet). we investigated whether the introduction of tamias sibiricus in sénart could alter the density of infected ticks. moreover, the densit ... | 2017 | 28846709 |
| prevalence and distribution of borrelia and babesia species in ticks feeding on dogs in the u.k. | ticks were collected during march-july 2015 from dogs by veterinarians throughout the u.k. and used to estimate current prevalences and distributions of pathogens. dna was extracted from 4750 ticks and subjected to polymerase chain reaction and sequence analysis to identify borrelia burgdorferi sensu lato (spirochaetales: spirochaetaceae) and babesia (piroplasmida: babesiidae) species. of 4737 ticks [predominantly ixodes ricinus linneaus (ixodida: ixodidae)], b. burgdorferi s.l. was detected in ... | 2017 | 28846148 |
| prevalence of borrelia miyamotoi and borrelia burgdorferi sensu lato in questing ticks from a recreational coniferous forest of east saxony, germany. | the hard tick ixodes ricinus is the most important vector of tick-transmitted pathogens in europe, frequently occurring in urban parks and greenbelts utilized for recreational activities. this species is the most common vector of the causative agents of lyme borreliosis in europe. similarly, the species spreads borrelia miyamotoi, causing a relapsing-fever like illness. a total of 1774 ixodes ricinus (50 females, 68 males, 840 nymphs and 818 larvae) were collected with flagging between march and ... | 2017 | 28843481 |
| the role of host immune cells and borrelia burgdorferi antigens in the etiology of lyme disease. | lyme disease is a zoonosis caused by infection with bacteria belonging to the borrelia burgdorferi species after the bite of an infected tick. even though an infection by this bacterium can be effectively treated with antibiotics, when the infection stays unnoticed b. burgdorferi can persist and chronic post-treatment lyme disease syndrome is able to develop. although a cellular and humoral response is observed after an infection with the borrelia bacteria, these pathogens are still capable to s ... | 2017 | 28840838 |
| chronic lyme disease: an unresolved controversy. | 2017 | 28838739 | |
| sleeper cells: the stringent response and persistence in the borreliella (borrelia) burgdorferi enzootic cycle. | infections with tick-transmitted borreliella (borrelia) burgdorferi, the cause of lyme disease, represent an increasingly large public health problem in north america and europe. the ability of these spirochetes to maintain themselves for extended periods of time in their tick vectors and vertebrate reservoirs is crucial for continuance of the enzootic cycle as well as for the increasing exposure of humans to them. the stringent response mediated by the alarmone (p)ppgpp has been determined to b ... | 2017 | 28836724 |
| two distinct mechanisms govern rpos-mediated repression of tick-phase genes during mammalian host adaptation by borrelia burgdorferi, the lyme disease spirochete. | the alternative sigma factor rpos plays a key role modulating gene expression in borrelia burgdorferi, the lyme disease spirochete, by transcribing mammalian host-phase genes and repressing σ(70)-dependent genes required within the arthropod vector. to identify cis regulatory elements involved in rpos-dependent repression, we analyzed green fluorescent protein (gfp) transcriptional reporters containing portions of the upstream regions of the prototypical tick-phase genes ospab, the glp operon, a ... | 2017 | 28830947 |
| nonpyrogenic molecular adjuvants based on norabu-muramyldipeptide and norabu-glucosaminyl muramyldipeptide: synthesis, molecular mechanisms of action, biological activities in vitro and in vivo. | apyrogenic fatty acyl analogues of muramyldipeptide (mdp) (abbreviated n-l18norabugmdp, n-b30norabugmdp, norabumdp-lys(l18), norabumdp-lys(b30), norabugmdp-lys(l18), norabugmdp-lys(b30), (b30)norabumdp, (l18)norabumdp) were designed and synthesized comprising the normuramyl-l-α-aminobutanoyl (norabu) structural moiety. all new analogues show depressed pyrogenicity both as free compounds and in liposomal formulations when tested in vivo in rabbits (s.c. and i.v. application). the potency of analo ... | 2017 | 28829599 |
| postinfectious anti-myelin oligodendrocyte glycoprotein antibody positive optic neuritis and myelitis. | we report the case of a 9-year-old girl admitted with fever, headache, and a cerebrospinal fluid lymphocytic pleocytosis. polymerase chain reaction was positive for human herpes virus 6. she subsequently developed ataxia and bilateral loss of vision. magnetic resonance imaging (mri) showed bilateral optic nerve lesions with extension to optic chiasm and a short-segment myelitis. serologic studies were positive for borrelia burgdorferi igm. anti-aquaporin 4 antibody was negative and anti-myelin o ... | 2017 | 28820014 |
| suicidal and homicidal tendencies after lyme disease: an ignored problem. | 2017 | 28814875 | |
| metabolic differentiation of early lyme disease from southern tick-associated rash illness (stari). | lyme disease, the most commonly reported vector-borne disease in the united states, results from infection with borrelia burgdorferi. early clinical diagnosis of this disease is largely based on the presence of an erythematous skin lesion for individuals in high-risk regions. this, however, can be confused with other illnesses including southern tick-associated rash illness (stari), an illness that lacks a defined etiological agent or laboratory diagnostic test, and is coprevalent with lyme dise ... | 2017 | 28814545 |
| exposure to vector-borne pathogens in privately owned dogs living in different socioeconomic settings in brazil. | this survey was conducted in four brazilian cities, from three federative units (pernambuco, minas gerais, and federal district), representing different socioeconomic settings, to determine the presence of antibodies to or antigens and dna of selected pathogens in privately owned dogs. from january to april 2015, blood and serum samples were collected and assayed using different tests. in particular, antibodies to anaplasma spp., borrelia burgdorferi sensu lato, and ehrlichia spp., and antigens ... | 2017 | 28807290 |
| ecological factors influencing small mammal infection by anaplasma phagocytophilum and borrelia burgdorferi s.l. in agricultural and forest landscapes. | small mammals are key components of numerous tick-borne disease systems, as hosts for immature ticks and pathogen reservoirs. to study the factors influencing tick-borne infection in small mammals, we trapped small mammals and collected questing ticks in spring and autumn in 2012 and 2013 at 24 sites in a 10x15 km rural landscapes (brittany, france). tissue samples were screened by real-time pcr for anaplasma phagocytophilum and borrelia burgdorferi sensu lato. of the two dominant small mammal s ... | 2017 | 28799685 |
| detecting and attributing health burdens to climate change. | detection and attribution of health impacts caused by climate change uses formal methods to determine a) whether the occurrence of adverse health outcomes has changed, and b) the extent to which that change could be attributed to climate change. there have been limited efforts to undertake detection and attribution analyses in health. | 2017 | 28796635 |
| the humtick study: protocol for a prospective cohort study on post-treatment lyme disease syndrome and the disease and cost burden of lyme borreliosis in belgium. | in belgium, different routine surveillance systems are in place to follow-up lyme borreliosis trends. however, accurate data on the disease and monetary burden for the different clinical manifestations are lacking. despite recommended antibiotic treatment, a proportion of lyme patients report persisting aspecific symptoms for six months or more (e.g. fatigue, widespread musculoskeletal pain, cognitive difficulties), a syndrome now named "post-treatment lyme disease syndrome" (ptlds). controversy ... | 2017 | 28794875 |
| leptospira spp. vaccinal antibodies do not react with borrelia burgdorferi peptides used in the accuplex 4. | we attempted to determine if leptospira spp. antibodies induced by vaccination would cross-react with borrelia burgdorferi antigens used in a commercial automated immunofluorescent assay (accuplex 4 biocd; antech). staff- and student-owned dogs ( n = 31) were recruited at a veterinary teaching hospital in a b. burgdorferi nonendemic area. the dogs were randomized and administered 1 of 4 commercial leptospira spp. vaccines that contained serovars canicola, grippotyphosa, icterohaemorrhagiae, and ... | 2017 | 28782459 |
| [research progress in laboratory diagnosis of lyme disease]. | 2017 | 28780833 | |
| impact of life stage-dependent dispersal on the colonization dynamics of host patches by ticks and tick-borne infectious agents. | when colonization and gene flow depend on host-mediated dispersal, a key factor affecting vector dispersal potential is the time spent on the host for the blood meal, a characteristic that can vary strongly among life history stages. using a 2-patch vector-pathogen population model and seabird ticks as biological examples, we explore how vector colonization rates and the spread of infectious agents may be shaped by life stage-dependent dispersal. we contrast hard (ixodidae) and soft (argasidae) ... | 2017 | 28778181 |
| seroprevalence and risk factors associated with ehrlichia canis, anaplasma spp., borrelia burgdorferi sensu lato, and d. immitis in hunting dogs from southern italy. | canine vector-borne diseases (cvbds) are caused by a range of pathogens transmitted to dogs by arthropods. the present study investigates ehrlichia canis, anaplasma spp., borrelia burgdorferi sensu lato, and dirofilaria immitis seroprevalences in hunting dogs from southern italy. dogs (no. 1335) were tested using a commercial in-clinic enzyme-linked immunosorbent assay kit. odds ratios (ors) were calculated by logistic regression analysis to identify risk factors. overall, 138/1335 dogs (10.3%) ... | 2017 | 28776227 |
| modulation of the tick gut milieu by a secreted tick protein favors borrelia burgdorferi colonization. | the lyme disease agent, borrelia burgdorferi, colonizes the gut of the tick ixodes scapularis, which transmits the pathogen to vertebrate hosts including humans. here we show that b. burgdorferi colonization increases the expression of several tick gut genes including pixr, encoding a secreted gut protein with a reeler domain. rna interference-mediated silencing of pixr, or immunity against pixr in mice, impairs the ability of b. burgdorferi to colonize the tick gut. pixr inhibits bacterial biof ... | 2017 | 28775250 |
| interactions between host immune response and antigenic variation that control borrelia burgdorferi population dynamics. | the population dynamics of pathogens within hosts result from interactions between host immune responses and mechanisms of the pathogen to evade or resist immune responses. vertebrate hosts have evolved adaptive immune responses to eliminate the infection, while many pathogens evade immune clearance through altering surface antigens. such interactions can result in a characteristic pattern of pathogen population dynamics within hosts consisting of population growth after infection, rapid populat ... | 2017 | 28771127 |
| improved serodiagnostic performance for lyme disease by use of two recombinant proteins in elisa as compared to standardized two tier testing. | the most reliable test method for the serological confirmation of lyme disease (ld) is a 2-tiered method recommended by the cdc in 1995. the first-tier test is a low specificity elisa test and the second-tier tests are higher specificity igg and igm western blots. this study describes the selection of two borrelia burgdorferi-recombinant proteins and evaluation of their performance in a simple 1-tier test for the serological confirmation of ld. these two proteins were generated from (a) the full ... | 2017 | 28768731 |
| bioassays to evaluate non-contact spatial repellency, contact irritancy, and acute toxicity of permethrin-treated clothing against nymphal ixodes scapularis ticks. | summer-weight clothing articles impregnated with permethrin are available as a personal protective measure against human-biting ticks in the united states. however, very few studies have addressed the impact of contact with summer-weight permethrin-treated textiles on tick vigor and behavior. our aim was to generate new knowledge of how permethrin-treated textiles impact nymphal ixodes scapularis ticks, the primary vectors in the eastern united states of the causative agents of lyme disease, hum ... | 2017 | 28754599 |
| detection of lyme disease causing borrelia burgdorferi s.l. in questing ixodes ricinus ticks on jersey. | 2017 | 28751172 | |
| deceptive lyme disease diagnosis linked with serious infections. | 2017 | 28742918 | |
| predicting the risk of lyme borreliosis after a tick bite, using a structural equation model. | understanding and quantification of the risk of lyme borreliosis after a tick bite can aid development of prevention strategies against lyme borreliosis. | 2017 | 28742149 |
| lyme and dopaminergic function: hypothesizing reduced reward deficiency symptomatology by regulating dopamine transmission. | the principal vector of lyme disease in the united states is ixodes scapularis: black legged or deer ticks. there is increased evidence that those infected may be plagued by anxiety or depression as well. researchers have identified transcripts coding for two putative cytosolic sulfotransferases in these ticks, which recognized phenolic monoamines as their substrates. it is hypothesized that protracted lyme disease sequelae may be due to impairment of dopaminergic function of the brain reward ci ... | 2017 | 28736624 |
| bactericidal activity of octenidine to various genospecies of borrelia burgdorferi, sensu lato spirochetes in vitro and in vivo. | the aim of our studies was to invent a reliable method for detection of the bactericidal activity of disinfectants against borrelia burgdorferi in suspension (in vitro) and in cell line cultures (in vivo). in the suspension method, 0.01% octenidine at 20°c and 35°c was bactericidal to borrelia afzeli; borrelia garini, b. burgdorferi sensu stricto after 5 minutes treatment. increase of the temperature to 35°c speed up the bactericidal effect to 1 minute. the bactericidal action of octenidine towa ... | 2017 | 28735308 |
| infectious diseases causing autonomic dysfunction. | to review infectious diseases that may cause autonomic dysfunction. | 2017 | 28730326 |
| brave new worlds: the expanding universe of lyme disease. | projections around the globe suggest an increase in tick-vectored disease incidence and distribution, and the potential for emergence of novel tick-borne pathogens. lyme disease is the most common reported tick-borne illness in the unites states and is prevalent throughout much of central europe. in recent years, the worldwide burden of lyme disease has increased and extended into regions and countries where the disease was not previously reported. in this review, we discuss the trends for incre ... | 2017 | 28727515 |
| lyme borreliosis in finland, 1995-2014. | we investigated the epidemiology of lyme borreliosis (lb) in finland for the period 1995-2014 by using data from 3 different healthcare registers. we reviewed data on disseminated lb cases from the national infectious diseases register (21,051 cases) and the national hospital discharge register (10,402 cases) and data on primary lb (erythema migrans) cases from the register for primary health care visits (11,793 cases). incidence of microbiologically confirmed disseminated lb cases increased fro ... | 2017 | 28726624 |
| serologic evidence of powassan virus infection in patients with suspected lyme disease(1). | powassan virus (powv) lineage ii is an emerging tickborne flavivirus with an unknown seroprevalence in humans. in a lyme disease-endemic area, we examined the seroreactivity to powv in 2 patient cohorts and described the clinical features of the powv-seroreactive patients. powv disease might be less neuroinvasive than previously thought. | 2017 | 28726610 |
| cascading effects of predator activity on tick-borne disease risk. | predators and competitors of vertebrates can in theory reduce the density of infected nymphs (din)-an often-used measure of tick-borne disease risk-by lowering the density of reservoir-competent hosts and/or the tick burden on reservoir-competent hosts. we investigated this possible indirect effect of predators by comparing data from 20 forest plots across the netherlands that varied in predator abundance. in each plot, we measured the density of questing ixodes ricinus nymphs (don), din for thr ... | 2017 | 28724731 |
| risk factors for severe infection, hospitalization, and prolonged antimicrobial therapy in patients with babesiosis. | babesiosis is an emerging tick-borne disease transmitted by the hard tick ixodes scapularis, which also transmits lyme disease. better gradation of prognostic indicators are needed to determine which patients may develop serious complications requiring hospitalization, and to provide early guidance on appropriate therapy. in this study, we evaluated 128 patients with smear or real time polymerase chain reaction-confirmed babesia microti infections over a period of 16 years. patients with aspleni ... | 2017 | 28722598 |
| phagocytic receptors activate syk and src signaling during borrelia burgdorferi phagocytosis. | phagocytosis of the lyme disease causing pathogen borrelia burgdorferi has been shown to be important in generating an inflammatory response to the pathogen. as a result, understanding the mechanisms of phagocytosis has been an area of great interest in the field of lyme disease. several cell surface receptors that participate in b. burgdorferi phagocytosis have been reported, including scavenger receptor marco and integrin α3β1. we sought to define the mechanisms by which these receptors mediat ... | 2017 | 28717031 |
| [borrelia miyamotoi: a recently identified human pathogenic tick-borne relapsing fever spirochete]. | borrelia miyamotoi is a recently described relapsing fever spirochete transmitted by ticks of the ixodes ricinus complex. this pathogen is different from borrelia burgdorferi sensu lato (the lyme borreliosis spirochetes) in its epidemiology, ecology and also genetics. over 50 patients have been described worldwide with borrelia miyamotoi disease, and three immunocompromised patients were reported with neurological symptoms. our knowledge about borrelia miyamotoi infection in ticks and its distri ... | 2017 | 28714333 |
| lyme carditis buried beneath st-segment elevations. | lyme disease is caused by the spirochete borrelia burgdorferi and is carried to human hosts by infected ticks. there are nearly 30,000 cases of lyme disease reported to the cdc each year, with 3-4% of those cases reporting lyme carditis. the most common manifestation of lyme carditis is partial heart block following bacterial-induced inflammation of the conducting nodes. here we report a 45-year-old gentleman that presented to the hospital with intense nonradiating chest pressure and tightness. ... | 2017 | 28713599 |
| clinical association: lyme disease and guillain-barre syndrome. | guillain-barre syndrome (gbs) is a life-threatening condition in which patients may present to the emergency department in respiratory distress leading to death. the early identification and treatment of such a condition is paramount in preventing mortality. while there are many infections associated with gbs, the association with lyme disease is uncommon. through our case we aim to highlight borrelia burgdorferi as an important antecedent infection associated with the development of gbs. in thi ... | 2017 | 28711274 |
| completed genome sequences of borrelia burgdorferi sensu stricto b31(nrz) and closely related patient isolates from europe. | borrelia burgdorferi sensu stricto is a causative agent of human lyme borreliosis in the united states and europe. we report here the completed genome sequences of strain b31 isolated from a tick in the united states and two closely related strains from europe, pali and pabe, which were isolated from patients with erythema migrans and neuroborreliosis, respectively. | 2017 | 28705983 |
| progression of lyme disease to bell's palsy despite treatment with doxycycline. | 2017 | 28705754 | |
| crossed total hemiatrophy associated with atrophoderma of pasini-pierini. | a 45-year-old chinese man had begun to show asymmetry of the face 30 years previously. subsequently, he developed visual extinction of the right eye, slight numbness, and weakness of the left extremities. simultaneously, multiple atrophic brownish patches occurred on his side. he denied prior trauma or tick bites at those sites. there was no report of preceding redness, induration, or a history of trauma. the atrophic lesions extended and enlarged slowly. ten years previously, some brownish patc ... | 2017 | 28705290 |
| [one year of infectious diseases : a review]. | several outbreaks have made the news in 2016 : ebola has come at an end, zika is booming and a resurgence of yellow fever takes place in africa. in switzerland, two hospital outbreaks have been reported, caused by mycobacterium chimerae and burkholderia cepacia. a major new article has consolidated the notion that prolonged antibiotic therapy is unnecessary in lyme disease. as multiresistant bacteria are increasing in frequency, innovative therapeutic approaches are under development. for lung i ... | 2017 | 28703540 |
| a mercury toxicity case complicated by hyponatremia and abnormal endocrinological test results. | mercury (hg) poisoning is considered a rare disease by the national institutes of health and the diagnosis can present great challenges to clinicians. children who are exposed to hg can present with a wide variety of symptoms, including acrodynia, tremor, excessive salivation, and psychiatric symptoms, including insomnia. however, endocrinologic manifestations from hg exposure are less well known. this is a case report of a 12-year-old boy who presented with body rash, irritability, insomnia, an ... | 2017 | 28701428 |
| culture and identification of borrelia spirochetes in human vaginal and seminal secretions. | background: recent reports indicate that more than 300,000 cases of lyme disease are diagnosed yearly in the usa. preliminary clinical, epidemiological and immunological studies suggest that infection with the lyme disease spirochete borrelia burgdorferi (bb) could be transferred from person to person via intimate human contact without a tick vector. failure to detect viable borrelia spirochetes in vaginal and seminal secretions would argue against this hypothesis. methods: patients with and wit ... | 2014 | 28690828 |
| modeling the effects of variable feeding patterns of larval ticks on the transmission of borrelia lusitaniae and borrelia afzelii. | spirochetes belonging to the borrelia burgdoferi sensu lato (sl) group cause lyme borreliosis (lb), which is the most commonly reported vector-borne zoonosis in europe. b. burgdorferi sl is maintained in nature in a complex cycle involving ixodes ricinus ticks and several species of vertebrate hosts. the transmission dynamics of b. burgdorferi sl is complicated by the varying competence of animals for different genospecies of spirochetes that, in turn, vary in their capability of causing disease ... | 2017 | 28690096 |
| babesiosis surveillance - wisconsin, 2001-2015. | babesiosis is an emerging zoonotic disease caused primarily by babesia microti, an intraerythocytic protozoan. babesia microti, like the causal agents for lyme disease and anaplasmosis, is endemic to the northeastern and upper midwestern united states where it is usually transmitted by the blacklegged tick, ixodes scapularis. although babesiosis is usually a mild to moderate illness, older or immunocompromised persons can develop a serious malaria-like illness that can be fatal without prompt tr ... | 2017 | 28683059 |
| management of lyme disease in european children: a review for practical purpose. | lyme disease is a tick-borne zoonosis transmitted through a bite of a tick carrying a spirochete belonging to borrelia species. in the last 20 years, the reported incidence of lyme disease is increased by three times in europe. clinically, the illness develops through a primary stage with a typical skin rash (erythema marginatum), then a secondary stage with possible neurologic or cardiac involvement. the last stage (chronic lyme disease) is mainly represented by arthritis or late neurological c ... | 2017 | 28681315 |
| a biochip-based combined immunoassay for detection of serological status of borrelia burgdorferi in lyme borreliosis. | dithiobis (succinimidyl undecanoate) modified gold surface biochip were used as a combined immunoassay platform for concurrently detecting immune responses to borrelia burgdorferi (b. burgdorferi) sensu lato antigens, flagellin, outer surface protein c, variable major protein-like sequence proteins, and 3 vlse protein ir6 peptides. the peptides represented intrinsic borrelia genospecies: b. burgdorferi sensu stricto, b. garinii, and b. afzelii, respectively. | 2017 | 28676442 |
| vaccination of horses with lyme vaccines for dogs induces short-lasting antibody responses. | borrelia burgdorferi can induce lyme disease. approved lyme vaccines for horses are currently not available. in an effort to protect horses, veterinarians are using lyme vaccines licensed for dogs. however, data to assess the response of horses to, or determine the efficacy of this off-label vaccine use are missing. here, antibodies against outer surface protein a (ospa), ospc, and ospf were quantified in diagnostic serum submissions from horses with a history of vaccination with canine lyme vac ... | 2017 | 28668566 |
| necrotizing autoimmune myopathy: a rare variant of idiopathic inflammatory myopathies. | idiopathic inflammatory myopathies are an unusual group of myopathies with annual incidence of 1 in 100 000 people in the united states. necrotizing autoimmune myopathy comprises only 16% of this group. it usually presents with severe proximal weakness, lower extremity weakness, and severe fatigue while very rarely does it present with dysphagia and respiratory muscle weakness. statin use, cancer, and connective tissue disorder are the usual associated risk factors. anti-signal recognition parti ... | 2017 | 28660228 |
| diagnosis of lyme-associated uveitis: value of serological testing in a tertiary centre. | to determine the frequency and clinical presentation of lyme disease in patients with uveitis and to assess the value of borrelia burgdorferi serological testing. | 2017 | 28659389 |
| small rnas of borrelia burgdorferi: characterizing functional regulators in a sea of srnas . | borrelia (borreliella) burgdorferi and closely related genospecies are the causative agents of lyme disease, the most common tick-borne disease north of the equator. the bacterium, a member of the spirochete phylum, is acquired by a tick vector that feeds on an infected vertebrate host and is transmitted to another vertebrate during subsequent feeding by the next tick stage. the precise navigation of this enzootic cycle entails the regulation of genes required for these two host-specific phases ... | 2017 | 28656017 |
| segregation lag in polyploid cells of the pathogen genus borrelia: implications for antigenic variation . | relapsing fever agents like borrelia hermsii undergo multiphasic antigenic variation that is attributable to spontaneous dna non-reciprocal transpositions at a particular locus in the genome. this genetic switch results in a new protein being expressed on the cell surface, allowing cells with that phenotype to escape prevailing immunity. but the switch occurs in only one of several genomes in these spirochetes, and a newly-switched gene is effectively "recessive" until homozygosity is achieved. ... | 2017 | 28656008 |
| interaction of primary mast cells with borrelia burgdorferi (sensu stricto): role in transmission and dissemination in c57bl/6 mice. | borrelia burgdorferi (sensu lato), the causative agent of lyme borreliosis is a bacterium transmitted by hard ticks, ixodes spp. bacteria are injected into the host skin during the tick blood meal with tick saliva. there, borrelia and saliva interact together with skin cells such as keratinocytes, fibroblasts, mast cells and other specific immune cells before disseminating to target organs. | 2017 | 28655322 |
| neuroborreliosis in swedish children: a population-based study on incidence and clinical characteristics. | borrelia burgdorferi is a common cause of bacterial meningitis but there are very few studies on incidence in europe. | 2017 | 28654563 |
| adult-onset opsoclonus-myoclonus-ataxia syndrome as a manifestation of brazilian lyme disease-like syndrome: a case report and review of literature. | described in 1962, the opsoclonus-myoclonus-ataxia syndrome (omas) is a rare, neurologically debilitating disorder with distinct characteristics that may begin in childhood or adult life. although many cases remain without etiological diagnosis, others are related to neoplasms and infectious diseases. we report a 41-year-old previously healthy male with an 8-day history of headache, vertigo, nausea, vomiting, and nystagmus. after a normal brain computed tomography and lymphocytic pleocytosis in ... | 2017 | 28652990 |
| in vivo imaging of lyme arthritis in mice by [(18)f]fluorodeoxyglucose positron emission tomography/computed tomography. | lyme borreliosis (lb) is a tick-borne infectious disease caused by borrelia burgdorferi spirochaetes, which are able to disseminate from the tick-bite site to distant organs. mouse models are widely used to study lb and especially lyme arthritis (la), but only a few whole-animal in vivo imaging studies on the pathogenesis of b. burgdorferi infection in mice have been published so far. the existing imaging techniques have their drawbacks and, therefore, novel tools to complement the array of avai ... | 2017 | 28649922 |
| reciprocal cooperation of phytochemicals and micronutrients against typical and atypical forms of borrelia sp. | borrelia sp., a causative pathogenic factor of lyme disease (ld), has become a major public health threat. current treatments based on antibiotics often lead to relapse after their withdrawal. naturally derived substances that could work synergistically to display higher efficacy compared with the individual components may serve as a resource for the development of novel approaches to combat both active and latent forms of borrelia sp. | 2017 | 28644529 |
| regulation of escherichia coli pathogenesis by alternative sigma factor n. | σ(n) (also σ(54)) is an alternative sigma factor subunit of the rna polymerase complex that regulates the expression of genes from many different ontological groups. it is broadly conserved in the eubacteria with major roles in nitrogen metabolism, membrane biogenesis, and motility. σ(n) is encoded as the first gene of a five-gene operon including rpon (σ(n)), ptsn, hpf, rapz, and npr that has been genetically retained among species of escherichia, shigella, and salmonella. in an increasing numb ... | 2017 | 28635589 |
| concurrent babesiosis and serological evidence of lyme disease in a young patient. | human babesiosis co-infected with lyme disease in a young patient is an important condition. here, we describe a case of a 39-year-old male patient with concurrent babesiosis and lyme disease. co-infections of tick borne diseases are often difficult to diagnose and underreported, and resulting in significant morbidity and mortality to patients. while co-infections have been infrequently described, it is of paramount importance that clinicians should be able to diagnose early and treat them effec ... | 2017 | 28634526 |
| range expansion and increasing borrelia burgdorferi infection of the tick ixodes scapularis (acari: ixodidae) in iowa, 1990-2013. | a passive surveillance program monitored ticks submitted by the public in iowa from 1990-2013. submitted ticks were identified to species and life stage, and ixodes scapularis say nymphs and adults were tested for the presence of borrelia burgdorferi. an average of 2.6 of iowa's 99 counties submitted first reports of i. scapularis per year over the surveillance period, indicating expansion of this tick species across the state. the proportion of vector ticks infected by b. burgdorferi increased ... | 2017 | 28633503 |
| pet ownership increases human risk of encountering ticks. | we examined whether pet ownership increased the risk for tick encounters and tickborne disease among residents of three lyme disease-endemic states as a nested cohort within a randomized controlled trial. information about pet ownership, use of tick control for pets, property characteristics, tick encounters and human tickborne disease were captured through surveys, and associations were assessed using univariate and multivariable analyses. pet-owning households had 1.83 times the risk (95% ci = ... | 2017 | 28631423 |
| borrelia burgdorferi infection induces lipid mediator production during lyme arthritis. | experimental lyme arthritis provides a mouse model for exploring the development of pathology following infection of c3h mice with borrelia burgdorferi. infected mice develop a reliable inflammatory arthritis of the ankle joint with severity that typically peaks around two to three weeks post-infection and then undergoes spontaneous resolution. this makes experimental lyme arthritis an excellent model for investigating the mechanisms that drive both the development and resolution phases of infla ... | 2017 | 28630010 |
| doctor says you are cured, but you still feel the pain. borrelia dna persistence in lyme disease. | lyme disease is a zoonosis caused by infection with borrelia burgdorferi (bb). a great amount of research has attempted to elucidate the mechanisms by which bb causes inflammation and chronic symptomatology in some patients. patients often seek unconventional treatments that lack scientific evidence, as medical care is unable to effectively explain and treat their illness. bb-dna can persist for long periods of time in some individuals, even after antibiotic therapy. herein, scientific rationale ... | 2017 | 28625898 |
| a dual luciferase reporter system for b. burgdorferi measures transcriptional activity during tick-pathogen interactions. | knowledge of the transcriptional responses of vector-borne pathogens at the vector-pathogen interface is critical for understanding disease transmission. borrelia (borreliella) burgdorferi, the causative agent of lyme disease in the united states, is transmitted by the bite of infected ixodes sp. ticks. it is known that b. burgdorferi has altered patterns of gene expression during tick acquisition, persistence and transmission. recently, we and others have discovered in vitro expression of rnas ... | 2017 | 28620587 |
| serious bacterial infections acquired during treatment of patients given a diagnosis of chronic lyme disease - united states. | the term "chronic lyme disease" is used by some health care providers as a diagnosis for various constitutional, musculoskeletal, and neuropsychiatric symptoms (1,2). patients with a diagnosis of chronic lyme disease have been provided a wide range of medications as treatment, including long courses of intravenous (iv) antibiotics (3,4). studies have not shown that such treatments lead to substantial long-term improvement for patients, and they can be harmful (1,5). this report describes cases o ... | 2017 | 28617768 |
| is there a lyme-like disease in australia? summary of the findings to date. | lyme borreliosis is a common tick-borne disease of the northern hemisphere caused by the spirochaetes of the borrelia burgdorferi sensu lato (b. burgdorferi s. l.) complex. it results in multi-organ disease with arthritic, cardiac, neurological and dermatological manifestations. in the last twenty-five years there have been over 500 reports of an australian lyme-like syndrome in the scientific literature. however, the diagnoses of lyme borreliosis made in these cases have been primarily by clini ... | 2016 | 28616477 |
| blood donor borrelia burgdorferi sensu lato seroprevalence and history of tick bites at a northern limit of the vector distribution. | in order to study the antibody seroprevalence of the causal agent of lyme borreliosis, borrelia burgdorferi sensu lato (s.l.), and the history of tick bites at a geographical distribution limit of ixodes ricinus, we compared healthy blood donors in geographically extreme regions: the borreliosis-endemic vestfold county (59°n) and the region of northern norway. blood samples were screened using igg/vlse elisa, and positive/borderline samples were confirmed using c6 elisa and immunoblot assays. al ... | 2017 | 28612350 |
| impact of a freeway on the dispersal of ticks and ixodes ricinus-borne pathogens: forested resting areas may become lyme disease hotspots. | man-made barriers are well known for their effects on ecosystems. habitat fragmentation, for instance, is a recognised consequence of modern-day infrastructure. the aim of the present study was to investigate the diversity and abundance of tick species, as well as the risks of acquiring tick-borne infections in habitats adjacent to a freeway. therefore, ixodid ticks were collected from the vegetation at two-week intervals (in the main tick season, from march to june) in eight habitats of differe ... | 2017 | 28605964 |
| diagnostic utility of erythema migrans. | 2017 | 28605419 | |
| detection and differentiation of lyme spirochetes and other tick-borne pathogens from blood using real-time pcr with molecular beacons. | real-time pcr assays have recently been implemented in diagnostics for many bacterial pathogens, allowing rapid and accurate detection, which ultimately results in improved clinical intervention. here, we describe a sensitive method of detection for three common tick-borne pathogens borrelia burgdorferi, anaplasma phagocytophilum, and babesia microti since coinfections with these pathogens have started occurring with increasing frequency over the last several years in both north america and euro ... | 2017 | 28600768 |
| expansion of the lyme disease vector ixodes scapularis in canada inferred from cmip5 climate projections. | a number of studies have assessed possible climate change impacts on the lyme disease vector, ixodes scapularis. however, most have used surface air temperature from only one climate model simulation and/or one emission scenario, representing only one possible climate future. | 2017 | 28599266 |
| a protein-protein interaction dictates borrelial infectivity. | two borrelia burgdorferi interacting proteins, bb0238 and bb0323, play distinct roles in pathogen biology and infectivity although a significance of their interaction remained enigmatic. here we identified the polypeptide segment essential for bb0238-bb0323 interaction and examined how it supports spirochete infectivity. we show that the interaction region in bb0323 requires amino acid residues 22-200, suggesting that the binding encompasses discontinuous protein segments. in contrast, the inter ... | 2017 | 28592866 |
| the geographic distribution of ixodes scapularis (acari: ixodidae) revisited: the importance of assumptions about error balance. | the black-legged tick, ixodes scapularis say, is the primary vector of borrelia burgdorferi, a spirochete that causes lyme disease, in eastern north america. lyme disease risk has generally been considered to be focused in the northeast and the northern midwest in the united states, yet the distribution of the vector extends considerably more broadly. a recent analysis of the distribution of the species using ecological niche modeling approaches painted an odd biogeographic picture, in which the ... | 2017 | 28591858 |
| bosr is a novel fur family member responsive to copper and regulating copper homeostasis in borrelia burgdorferi. | the ferric uptake regulator (fur) family of dna-binding proteins represses and/or activates gene transcription via divalent metal ion-dependent signal sensing. the borrelia burgdorferi fur homologue, also known as borrelia oxidative stress regulator (bosr), promotes spirochetal adaptation to the mammalian host by directly repressing the lipoproteins required for tick colonization and indirectly activating those required for establishing infection in the mammal. here, we examined whether the dna- ... | 2017 | 28583949 |
| no evidence of borrelia mayonii in an endemic area for lyme borreliosis in france. | borrelia mayonii is currently the latest species belonging to the borrelia burgdorferi (sensu lato) complex to be discovered. interestingly it is involved in human pathology causing a high fever. we looked for its presence in post- tick bite febrile patients as well as in ixodes ricinus ticks in an endemic area of france. | 2017 | 28583197 |
| occurrence of <i>coxiella burnetii</i>, <i>ehrlichia canis</i>, <i>rickettsia</i> species and <i>anaplasma phagocytophilum</i>-like bacterium in ticks collected from dogs and cats in south africa. | ticks are major vectors of arthropod-borne infections and transmit a wide variety of zoonotic pathogens. this study was conducted mainly to determine the occurrence of canine tick-borne bacterial and rickettsial pathogens especially those with zoonotic potential. we examined 276 rhipicephalus sanguineus, 38 haemaphysalis elliptica and 4 amblyomma hebraeum ticks from 90 dogs and 4 cats from the free state, kwazulu-natal, north west and mpumalanga provinces. dna of coxiella burnetii (41%), ehrlich ... | 2017 | 28582983 |
| insights into pg-binding, conformational change, and dimerization of the ompa c-terminal domains from salmonella enterica serovar typhimurium and borrelia burgdorferi. | salmonella enterica serovar typhimurium can induce both humoral and cell-mediated responses when establishing itself in the host. these responses are primarily stimulated against the lipopolysaccharide and major outer membrane (om) proteins. ompa is one of these major om proteins. it comprises a n-terminal eight-stranded β-barrel transmembrane domain and a c-terminal domain (ompa(ctd) ). the ompa(ctd) and its homologs are believed to bind to peptidoglycan (pg) within the periplasm, maintaining b ... | 2017 | 28580643 |
| molecular evidence of borrelia burgdorferi sensu lato in patients in brazilian central-western region. | we aimed to detect dna of borrelia burgdorferi in whole blood and serum samples of patients with clinical symptoms and epidemiology compatible with brazilian lyme-like disease. four patients with positive epidemiological histories were recruited for the study. blood samples were collected, screened by serologic testing by elisa and western blotting and molecular identification of b. burgdorferi by amplifying a fragment of the conserved gene that synthesizes the hook flagellar flge. the results s ... | 2017 | 28579253 |
| t2 magnetic resonance assay-based direct detection of three lyme disease-related borrelia species in whole-blood samples. | in early lyme disease (ld), serologic testing is insensitive and seroreactivity may reflect active or past infection. in this study, we evaluated a novel assay for the direct detection of three species of borrelia spirochetes in whole blood. the t2 magnetic resonance (t2mr) assay platform was used to amplify borrelia dna released from intact spirochetes and to detect amplicon. analytical sensitivity was determined from blood spiked with known concentrations of spirochetes, and the assay's limit ... | 2017 | 28566314 |
| bibrachial plegia due to lyme radiculopoliomyelitis-myelitis. | nervous system involvement occurs in up to 15% of patients with lyme disease, most commonly manifested as cranial neuropathy, lymphocytic meningitis, and or radiculoneuritis. we describe a patient with subacute radiculopoliomyelitis-myelitis matching the selective involvement of the anterior horns and roots of the cervical spinal cord seen on mri and on electrodiagnostic studies. we demonstrate positive csf lyme antibodies and document a near-complete recovery with antibiotics. this case highlig ... | 2017 | 28566141 |
| receptor tyrosine kinases play a significant role in human oligodendrocyte inflammation and cell death associated with the lyme disease bacterium borrelia burgdorferi. | in previous studies, human oligodendrocytes were demonstrated to undergo apoptosis in the presence of borrelia burgdorferi under an inflammatory milieu. subsequently, we determined that the mek/erk pathway played a significant role in triggering downstream inflammation as well as apoptosis. however, the identity of receptors triggered by exposure to b. burgdorferi and initiating signaling events was unknown. | 2017 | 28558791 |
| lost in plasmids: next generation sequencing and the complex genome of the tick-borne pathogen borrelia burgdorferi. | borrelia (b.) burgdorferi sensu lato, including the tick-transmitted agents of human lyme borreliosis, have particularly complex genomes, consisting of a linear main chromosome and numerous linear and circular plasmids. the number and structure of plasmids is variable even in strains within a single genospecies. genes on these plasmids are known to play essential roles in virulence and pathogenicity as well as host and vector associations. for this reason, it is essential to explore methods for ... | 2017 | 28558786 |
| europe-wide meta-analysis of borrelia burgdorferi sensu lato prevalence in questing ixodes ricinus ticks. | lyme borreliosis is the most common zoonotic disease transmitted by ticks in europe and north america. despite having multiple tick vectors, the causative agent, borrelia burgdorferisensu lato, is vectored mainly by ixodes ricinus in europe. in the present study, we aimed to review and summarize the existing data published from 2010 to 2016 concerning the prevalence of b. burgdorferi sensu lato spirochetes in questing i. ricinus ticks. the primary focus was to evaluate the infection rate of thes ... | 2017 | 28550059 |
| parsonage-turner syndrome secondary to lyme disease. | 2017 | 28549944 | |
| infection with borrelia chilensis in ixodes stilesi ticks collected from pudu puda deer. | lyme borreliosis is a vector-borne zoonosis caused by borrelia burgdorferi sensu lato species complex spirochetes, which are maintained in transmission cycles among vertebrates and ixodes ticks. recently, a new genospecies within this complex, borrelia chilensis, was described in ixodes stilesi collected from the environment and from rodents in chile. this tick also infests the native southern pudu deer (pudu puda). the objectives of this study were to investigate the prevalence, intensity of in ... | 2017 | 28549720 |
| borrelia species detected in ticks feeding on wild korean water deer (hydropotes inermis) using molecular and genotypic analyses. | lyme borreliosis is a vector-borne disease transmitted through the bite of ticks infected by borrelia burgdorferi sensu lato group, including b. burgdorferi sensu stricto, b. afzelii, and b. garinii. the goal of the present study was to detect borrelia species in ticks infesting wild korean water deer (kwd; hydropotes inermis swinhoe), using molecular and genotypic analyses. in total, 48 ticks were collected from kwd, all of which were morphologically identified as haemaphysalis longicornis neum ... | 2017 | 28549151 |
| detection and genetic characterization of a wide range of infectious agents in ixodes pavlovskyi ticks in western siberia, russia. | the ixodes pavlovskyi tick species, a member of the i. persulcatus/i. ricinus group, was discovered in the middle of the 20(th) century in the russian far east. limited data have been reported on the detection of infectious agents in this tick species. the aim of this study was to investigate the prevalence and genetic variability of a wide range of infectious agents in i. pavlovskyi ticks collected in their traditional and recently invaded habitats, the altai mountains and novosibirsk province, ... | 2017 | 28545549 |
| the abundance of the lyme disease pathogen borrelia afzelii declines over time in the tick vector ixodes ricinus. | the population dynamics of vector-borne pathogens inside the arthropod vector can have important consequences for vector-to-host transmission. tick-borne spirochete bacteria of the borrelia burgdorferi (sensu lato) species complex cause lyme borreliosis in humans and spend long periods of time (>12 months) in their ixodes tick vectors. to date, few studies have investigated the dynamics of borrelia spirochete populations in unfed ixodes nymphal ticks. | 2017 | 28545520 |
| importance of common wall lizards in the transmission dynamics of tick-borne pathogens in the northern apennine mountains, italy. | during the investigations on ticks and tick-borne pathogens (tbp) range expansion in the northern apennines, we captured 107 podarcis muralis lizards. sixty-eight animals were infested by immature ixodes ricinus, haemaphysalis sulcata and h. punctata. borrelia burgdorferi s.l. was detected in 3.7% of i. ricinus larvae and 8.0% of nymphs. together with the species-specific b. lusitaniae, we identified b. garinii, b. afzelii and b. valaisiana. rickettsia spp. (18.1% larvae, 12.0% nymphs), namely r ... | 2017 | 28540487 |
| candidatus neoehrlichia mikurensis and borrelia burgdorferi sensu lato detected in the blood of norwegian patients with erythema migrans. | the most common tick-borne human disease in norway is lyme borreliosis. ticks in norway also harbour less known disease-causing agents such as candidatus neoehrlichia mikurensis, borrelia miyamotoi and rickettsia helvetica. however, human infections caused by these pathogens have never been described in norway. the main aims of the study were to evaluate the contribution of several tick-borne bacterial agents, other than borrelia burgdorferi sensu lato, to zoonotic diseases in norway and to dete ... | 2017 | 28539197 |
| early-onset lyme carditis with concurrent disseminated erythema migrans. | lyme disease is an infection that is estimated to affect over 300,000 people in the united states annually. typically, it presents with erythema migrans (em), an annular rash at the site of tick attachment, within 3 to 30 days of inoculation. untreated patients may progress to early disseminated disease. a further complication, lyme carditis is rare but may occur several weeks later. it commonly manifests as a variable atrioventricular (av) conduction block, with a high-grade av block occurring ... | 2017 | 28533930 |
| practices of lyme disease diagnosis and treatment by general practitioners in quebec, 2008-2015. | lyme disease (ld), a multisystem infection caused by the spirochete borrelia burgdorferi sensu stricto (b. burgdorferi), is the most reported vector-borne disease in north america, and by 2020, 80% of the population in central and eastern canada could live in ld risk areas. among the key factors for minimising the impact of ld are the accurate diagnosis and appropriate management of patients bitten by ticks. in this study, the practices of quebec general practitioners (gps) on ld diagnosis and m ... | 2017 | 28532428 |
| lyme borreliae prevalence and genospecies distribution in ticks removed from humans. | lyme borreliosis (lb) is the most important human tick-borne disease, but borrelia genospecies cause different clinical manifestations. ticks of the genus ixodes removed from humans between 2006 and 2012 were analysed for borrelia burgdorferi sensu lato (sl) infections. the majority of ticks originated from the greater hanover region in northern germany. the engorgement status varied over the entire spectrum from unengorged (no evidence of started blood feeding) to fully engorged. in the present ... | 2017 | 28528880 |
| canine infection with borrelia burgdorferi, dirofilaria immitis, anaplasma spp. and ehrlichia spp. in canada, 2013-2014. | canine test results generated by veterinarians throughout canada from 2013-2014 were evaluated to assess the geographical distribution of canine infection with borrelia burgdorferi, dirofilaria immitis, ehrlichia spp., and anaplasma spp. | 2017 | 28526093 |
| clinical presentation and outcomes of children with human granulocytic anaplasmosis. | adults with the tick-borne disease human granulocytic anaplasmosis (hga) have a spectrum of acute febrile illnesses that, if untreated, might be severe. clinical presentation and outcomes of children with hga have been poorly described. | 2017 | 28520981 |
| rearing ixodes scapularis, the black-legged tick: feeding immature stages on mice. | ixodes scapularis, the vector of lyme disease, is one of the most important disease vectors in the eastern and midwestern united states. this species is a three host tick that requires a blood meal from a vertebrate host for each development stage, and the adult females require a blood meal for reproduction. larval ticks attach to their host for 3 - 5 days for feeding and drop off the host when fully engorged. this dependency on several different hosts and the lengthy attachment time for engorge ... | 2017 | 28518080 |
| relative risk for ehrlichiosis and lyme disease in an area where vectors for both are sympatric, new jersey, usa. | 2017 | 28518034 | |
| a case of early disseminated neurological lyme disease followed by atypical cutaneous manifestations. | lyme disease (ld) is a tick-borne illness caused by borrelia burgdorferi sensu stricto. an 80-year-old female from pennsylvania, usa, presented to an outside hospital with fever, confusion, lower extremity weakness, and stool incontinence. ct head and mri spine were unremarkable. an infectious work-up including lumbar puncture was negative. she was transferred to our tertiary care hospital. patient was noted to have mild unilateral right-sided facial droop and a diffuse macular rash throughout t ... | 2017 | 28512589 |