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[inotropic action of astragalus membranaceus bge. saponins and its possible mechanism].astragalus membranaceus saponins (ams) 50-200 micrograms/ml had a positive inotropic action on the isolated working heart of rats, but in the case of 30 micrograms/ml the inotropic action turned negative. the contractility recovered after washing out the ams. strophanthin k performed in a similar manner as ams. ams 500 micrograms/ml decreased the resting potential of cultured rat heart cells by 10 mv. the results suggest that ams plays its inotropic role through influencing the na-k-atpase.19921292500
shi-quan-da-bu-tang (ten significant tonic decoction), sqt. a potent chinese biological response modifier in cancer immunotherapy, potentiation and detoxification of anticancer drugs.shi-quan-da-bu-tang (ten significant tonic decoction), or sqt (juzentaihoto, tj-48) was formulated by taiping hui-min ju (public welfare pharmacy bureau) in chinese song dynasty in ad 1200. it is prepared by extracting a mixture of ten medical herbs (rehmannia glutinosa, paeonia lactiflora, liqusticum wallichii, angelica sinesis, glycyrrhiza uralensis, poria cocos, atractylodes macrocephala, panax ginseng. astragalus membranaceus and cinnamomum cassia) that tone the blood and vital energy, and s ...19921294861
[effects of astragalus membranaceus and tripterygium hypoglancum on natural killer cell activity of peripheral blood mononuclear in systemic lupus erythematosus].natural killer (nk) activity of peripheral blood mononuclear cells (pbmc) from 28 patients with systemic lupus erythematosus (sle) was measured using enzyme-release assay. the sle patients had significantly decreased nk activity in comparing with normal controls. the levels of nk activity correlated with disease activity. pre-incubation of pbmc separately with astragalus membranaceus and tripterygium hypoglaucum or with their mixture considerably stimulated nk cytotoxicity both in sle patients a ...19921301849
[effects of mixture of astragalus membranaceus, fructus ligustri lucidi and eclipta prostrata on immune function in mice].a chinese medicine mixture containing astragalus membranaceus, fructus ligustri lucidi and eclipta prostrata(afe), was fed to mice 9g/kg, 20g/kg, respectively for seven days. observe the effects of afe on the immune function in mice. the experiment showed that the two dosages of afe could obviously raise the conversion percentage of lymphocytes (p < 0.01) and serum igg level (41%-47%) of the mice. the weights of the thymus and spleensed increased in the two groups compared with those in the norm ...19921304546
[fungi isolated from diseased medicinal plants].one hundred and forty-four fungal isolates were obtained from diseased paeonia albiflora pall. var. trichocarpa bung., astragalus membranaceus bung., lithospermum erythrorhizon sieb. et zucc., ledebouriella seseloides wolff and bupleurum falcatum l. which were collected in the test field of tsukuba medicinal plant research station, national institute of hygienic sciences. most of them were identified into 15 genera containing 8 species. fungal species presumed to be pathogens of the host plants ...19921364438
mechanism of inhibition of hiv-1 infection in vitro by purified extract of prunella vulgaris.crude extracts of four chinese herbs, arctium lappa, astragalus membranaceus, andrographis paniculata, and prunella vulgaris, were assessed in several tissue culture lines for anti-hiv activity and for cytotoxicity. one extract, obtained from p. vulgaris, was able to significantly inhibit hiv-1 replication with relatively low cytotoxicity. the active factor was purified using sequential precipitations with ethanol and n-butanol, followed by reverse-phase and gel permeation high-performance liqui ...19921371029
chinese medicinal herbs modulate mutagenesis, dna binding and metabolism of aflatoxin b1.oldenlandia diffusa (od) and scutellaria barbata (sb) have been used in traditional chinese medicine for treating liver, lung and rectal tumors while astragalus membranaceus (am) and ligustrum lucidum (ll) are often used as an adjunct in cancer therapy. in this study, we determined the effects of aqueous extracts of these four herbs on aflatoxin b1 (afb1)-induced mutagenesis using salmonella typhimurium ta100 as the bacterial tester strain and rat liver 9000 x g supernatant as the activation sys ...19921377337
phytochemicals potentiate interleukin-2 generated lymphokine-activated killer cell cytotoxicity against murine renal cell carcinoma.the success of adoptive immunotherapy using recombinant interleukin-2 (ril-2) and lymphokine-activated killer (lak) cells in several cancers has been hampered by severe toxicity associated with high doses of ril-2. methods that reduce the dosage of ril-2 without loss of clinical efficacy are needed. in this study we determined the in vitro effect of a phytochemical immune modulator, astragalus membranaceus (am), and two fractions isolated by high-performance liquid chromatography on the cytotoxi ...19921445669
astragalus membranaceus stimulates human sperm motility in vitro.poor sperm motility is an important cause of male infertility. in an attempt to identify chinese medicinal herbs that might improve human sperm motility in vitro, we screened water extracts of 18 herbs with a trans-membrane migration method which measured the percentage of sperm that moved across the 5 micron pores of a nucleopore membrane from a semen-drug mixture into phosphate buffered saline during 2 hours incubation. astragalus membranaceus was the only herb that showed a significant stimul ...19921471613
[experimental study on yiqi-huoxue therapy of liver fibrosis].the experimental hepatic fibrosis was treated with yiqi (reinforcing qi, yq) huoxue (activating blood circulation, hx) principle which was consisted of astragalus membranaceus, ligusticum wallichii, paeonia lactiflora, etc. after stimulation with ccl4 over four months, the wistar rat developed liver fibrosis. rats were divided into the normal control, the toxifying control, yqhx group and hx group. the experimental period lasted over four months. results: (1) mortality of animal: both toxifying ...19921498545
[the effect of astragalus polysaccharide on endotoxin-induced toxicity in mice].astragalus polysaccharide (aps), an active component, was isolated from the radix of astragalus membranaceus bge var. mongholicus (bge) hsiao, and the effects of aps on e. coli endotoxin-induced liver damage were investigated in mice. the results showed that when mice were pretreated with aps (30, 60, 100 mg.kg-1.d-1 x 7d, ip), the survival rate of endotoxin intoxicated mice was increased the lowering of atp levels and adenylate energy charge in mouse liver could be prevented. aps 100 mg.kg-1 co ...19921529714
[clinical and experimental study of the effect of kang er xin-i on viral myocarditis].kang er xin-i (kex-i) is a proved recipe used to treat viral myocarditis. it consists of lonicera japonica, ophiopogon japonicus, astragalus membranaceus mainly and possesses the effect of clearing away heat and toxic materials and supplementing the vital energy and nourishing. the clinical study was carried out with kex-i according to a random, paired and cross-over design. coenzyme q10 was used as a control and left ventricular function was observed. the result showed: after being treated with ...19911659497
[effect of astragalus membranaceus on erythrocyte sodium content and sodium transport in the coronary heart disease].the purpose of this study was to investigate the effect of astragalus membranaceus (am) on erythrocyte sodium content and sodium transport in the coronary heart disease(chd). 67 cases of chd was randomly divided into treatment group (tg) and control group (cg), tg (45 cases) were treated with am intravenous 24 g/d infused into 5% glucose 250 ml, cg (22 cases) with 5% glucose 250 ml. after a curable stage of 14 days, results showed that the erythrocyte sodium content was markedly decreased and th ...19911667511
chinese medicinal herbs reverse macrophage suppression induced by urological tumors.tumors are known to produce factors suppressing macrophage function. in this study we demonstrated in vitro suppression of macrophage chemiluminescent oxidative burst associated with viable cells and cell-free extracts of two urological neoplasms--murine renal cell carcinoma (renca) and murine bladder tumor (mbt). suppression was reversed by extracts of two chinese medicinal herbs, astragalus membranaceus (am) and ligustrum lucidum (ll). murine macrophage cell line j774 was incubated with either ...19911856958
[primary research on the clinical significance of ventricular late potentials (vlps), and the impact of mexiletine, lidocaine and astragalus membranaceus on vlps].the body surface signal-averaged electrocardiogram (saecg) was recorded on 316 cardiac patients, 84% (266 patients) of whom were also taken 24-hour holter ecg. vlps were detected positively in 6.1%, 25%, 25.7%, 14.3% and 5.5% of patients with angina pectoris, myocardial infarction, myocarditis, cardiomyopathy and arrhythmia of unknown origin respectively, and the patients with complex ventricular arrhythmia had more vlps positive determination definitely (p less than 0.05). the specificity of vl ...19771879028
[effect of fu-zheng qu-xie on gastric disease infected with campylobacter pyloridis].chinese herbal medicine and gentamycin were used separately in the treatment of 75 cases of gastric disease by campylobacter pyloridis (cp). surveying the changes of the gastrofiberscope, pathological test, bacteriology and immunology. this study, found that in the chinese herbal medicine group clinical symptoms were obviously improving the effective rate for cp being 80% (24/30), the death rate for cp 30% (9/30), and the effective rate for patho-histological changes 50% (15/30). differences of ...19912065393
[the combined modulating effects of cerium nitrate with certain chinese traditional drugs on altered cell-mediated immunities in scald mice].altered cell-mediated immunities (cmi) is one of the important causes of increased susceptibility to infection and, high mortality of burned patients. this paper presents the experimental work on mice with scald injury to restore their altered cmi by local application of cerium nitrate (ce) or systemic administration of astragalus membranaceus (am) or lonicera japonica thunb (ljt), as well as combination use of these drugs. the proliferative response to con a and the ability of il-2 production o ...19902086133
[isolation and identification of chemical constituents of astragalus root].ten constituents have been isolated from the alcoholic extract of astragalus membranaceus var. monghlicum root. all of them were identified. among them astraisoflavanin (3s-(-)-mucronulatol-7-o-d-glucopyranoside) is a new compound. dimethyl 4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphyenyl 1-2, 2'-dicarboxylate is a known synthetic compound, but it was first isolated from natural resource astragalus root and identified by the authors.19902092578
enhancement of the immune response in mice by astragalus membranaceus extracts.astragalus membranaceus extracts injected into normal mice or mice immunodepressed by cyclophosphamide or radiation treatment or by aging are able to enhance the antibody response to a t-dependent antigen. optimal conditions for maximum effect have been established in normal c3h/hej and (c57b1/10 x dba/2)f1 mice. enhancement of the antibody response was associated with increase of th cell activity in normal and immunodepressed mice. the biological activity of endotoxin-free extracts is dependent ...20032149722
treatment of experimental coxsackie b-3 viral myocarditis with astragalus membranaceus in mice.a murine model system for observing the effect of astragalus membranaceus (am) on experimental myocarditis caused by coxsackie b-3 virus (cb3v) was developed in 4-week-old male balb/c mice. gross, histopathologic and ultrastructural examinations of the infected-am treated group showed that the severity and involved area of the myocardial lesions became milder and smaller than those in the infected-ns treated mice. the total lesion area, and the total lesion area/total myocardial area examined (% ...19902161724
effect of astragalus membranaceus on electric activities of cultured rat beating heart cells infected with coxsackie b-2 virus.astragalus membranaceus (am) which has a protective effect on rat beating heart cells infected experimentally with coxsackie b-2 virus was evaluated on the basis of changes in morphologic and electric activity of the cells. rhythm, beating frequency, beating percentage, cardiac cellular damage and cytopathic effects (cpe) were monitored every 24 h after challenge; electric activities parameters were measured by conventional intracellular microelectrode technique. significant protective effects w ...19902164463
viral etiology of chronic cervicitis and its therapeutic response to a recombinant interferon.chronic cervicitis was shown to be related to papillomavirus type 16(hpv-16), herpes simplex virus type 2 and cytomegalovirus (cmv) infections as demonstrated by dna hybridization technique and virus isolation method from samples taken from erosive and normal cervices. after one course of treatment with recombinant interferon alpha 1 (rifn-alpha 1), 93.8% of cases showed clinical improvement and 60% marked improvement. the hpv-16 and hsv detection rates dropped down significantly after rifn-alph ...19902173655
hepatoprotective effects of astraglus root.oral administration of an ethanol extract of the root of astragalus membranaceus alleviated liver injury induced by stilbenemidine. pre-administration in mice reduced elevated sgpt levels and subacute toxicity of stilbenemidine, decreased pentobarbital-induced loss of righting reflex and protected hepatic cells from pathological changes.19902255205
[f3, a fractionated extract of astragalus membranaceus, potentiates lymphokine-activated killer cell cytotoxicity generated by low-dose recombinant interleukin-2].success with ril-2 immunotherapy of human cancer appears to depend on the administration of high doses which are frequently associated with excessive toxicity. future use of ril-2 will require certain modifications based on the use of lower doses of ril-2 without significant loss of antitumor efficacy. the authors tested in vitro the possibility of potentiating the activity of ril-2 in terms of lak cell generation. the authors hypothesized that co-incubation of lak cell precursors with a chinese ...19902350835
[clinical study of 96 cases with chronic hepatitis b treated with jiedu yanggan gao by a double-blind method].this paper reported 96 cases with chronic hepatitis b treated by a double-blind method. there were 51 cases of observation group(og) and 45 cases of control group (cg). og was treated with jiedu yanggan gao consisting of artemisia capillaris, taraxacum mongolicum, plantago seed, cephalanoplos segetum, hedyotis diffusa, flos chrysanthemi indici, smilax glabra, astragalus membranaceus, salviae miltiorrhizae, fructus polygonii orientalis, radix paeoniae alba, polygonatum sibiricum, etc.). cg was pr ...19902364464
[immunomodulatory action of the total saponin of gynostemma pentaphylla].the specimen of the total saponin for this experimental study was extracted from gynostemma pentaphylla growing in suining county in hunan province. weight of immune organs, content of anti-srbc hemolysin, rate of special ea-rfc formation and percentage of nk cell activity had been employed for the study as experimental indices, both the normal healthy mice and the mice with immunity impairment due to cyclophosphamide (cy) management as experimental models. the results of the study exhibited: (1 ...19902364471
[preliminary study of traditional chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases].this paper reports the clinical treatment of 100 patients with minimal brain dysfunction (mbd), their age ranged from 7-14.2 years, and the average age was 10.5. patients were divided into tcm and wm group randomly. the tcm group (80 cases) were treated with the therapy of subdueing hyperactivity of the liver and invigorating the function of the spleen by using: bupleurum chinense, scutellaria baicalensis, astragalus membranaceus, codonopsis pilosula, ligustrum lucidum, lophatherum gracile and t ...19902397543
[advances in immuno-pharmacological studies on astragalus membranaceus]. 19862425990
[influence of yang-restoring herb medicines upon metabolism of thyroid hormone in normal rats and a drug administration schedule].large dose of yang-restoring herb medicines. (radix codonopsis pilosulae, astragalus membranaceus, radix aconiti praeparata, epimedium brevicornum, cortex cinnamomi and herba cistanchis) may exert an unfavorable effect on normal rats, i. e. natural weight gain reduced (p less than 0.01), serum t3 decreased (p less than 0.05), rt3, trh levels raised (p less than 0.01) and tsh showed a raising tendency. lower t3 and higher rt3 levels may be the effects of yang-restoring herb medicines on the perip ...19892500264
[effect of astragalus membranaceus on electrical activities of coxsackie b-2 virus-infected rat myocardial cells in culture].beating myocardial cell cultures of neonatal rats were prepared in vitro and infected with coxsackie b-2 virus. the cells were evaluated in the post-infected period for changes in beating percentage and cytopathic effect (cpe), alterations in the electrical activities by standard microelectrode techniques, and the protective effect of astragalus membranaceus (am) on coxsackie b-2 virus-infected neonatal rat myocardial cell cultures was observed. the beating percentage began to decrease in the in ...19892550160
[influence of astragalus membranaceus (am) polysaccharide fb on immunologic function of human periphery blood lymphocyte].chemotherapy and/or radiotherapy are believed to further lower the already low cellular immunologic response of cancer patients giving poorer prognosis. a number of chinese medicinal herbs known as fuzheng therapy (fzt), in which am is an active one, are being used to enhance the natural host defence function in cancer patients. among some fractions of am polysaccharide extracts, fb was the strongest. in vitro restorative effects of fb in 18 normal healthy individuals and in 9 previously untreat ...19892612327
[an experimental study on the anti-senility effects of shou xing bu zhi].this paper presents the anti-senility effects of shou xing bu zhi (sxbz. made of thirteen herbs: polygonum multiflorum, codonopsis silvestris, astragalus membranaceus, poria cocos, etc.) in mice. the mice were administered with the sxbz orally at dosage of 10 g/kg daily for three months. the results showed that the lipofuscin of liver and brain tissues was significantly reduced in both young (1 month old) and adult (11 months) mice. examination of lipid peroxidation of liver tissue revealed a ma ...19892758519
[a clinical study on the treatment of acute upper digestive tract hemorrhage with wen-she decoction].this paper deals with the prospective clinical study on treatment of acute upper digestive tract hemorrhage with wen-she decoction (wsd). an opened sequential controlled trial method of simple orientation quality reaction was adopted in this study. 7 cases were treated and all of them were cured. it was concluded that wsd was an excellent therapy to treat the middle or small amount hemorrhage of acute upper digestive tract. the effective rate of wsd of the stool ob (+) becoming (-) within 5 days ...19892766422
[immune restoration of local xenogeneic graft-versus-host reaction in cancer patients in vitro and reversal of cyclophosphamide-induced immune suppression in the rat in vivo by fractionated astragalus membranaceus].through the process of fractionation, purification by gel filtration chromatography and thereafter the screening with an in vitro local xenogeneic graft-versus-host reaction (xgvhr) model, a fraction was identified as a potent immunorestorative agent and was designated "fraction 3" (f3). using the xgvhr in vitro as a model assay for t cell function again, f3 was studied on mononuclear cells (mnc) from 13 cancer patients and exhibited significant immunorestorative activity, with an increase in lo ...19892789109
effect of astragalus membranaceus injecta on coxsackie b-2 virus infected rat beating heart cell culture. 19872827966
[quantitative determination of astragaloside a in astragalus membranaceus]. 19862952353
[pharmacological action of astragalus membranaceus on the central nervous system in mice]. 20102952357
immunotherapy with chinese medicinal herbs. i. immune restoration of local xenogeneic graft-versus-host reaction in cancer patients by fractionated astragalus membranaceus in vitro.the in vitro immunomodulatory activity of fractions derived from astragalus membranaceus, an herb commonly used in the practice of traditional chinese medicine, was first screened by studying their individual effects on mononuclear cells (mnc) derived from healthy normal donors using the local xenogeneic graft-versus-host reaction (xgvhr). sephacryl s-200 column-separated fraction 3 (mw 20,000-25,000) along with its crude extract precursor, fraction 7, and another crude extract derivative, fract ...19883260960
immunotherapy with chinese medicinal herbs. ii. reversal of cyclophosphamide-induced immune suppression by administration of fractionated astragalus membranaceus in vivo.a partially purified fraction (f3) with an estimated molecular weight of 20,000 to 25,000 derived from the traditional chinese medicinal herb astragalus membranaceus, was found to possess a potent immunorestorative activity in vitro. its capacity to aborogate the local xenogeneic graft versus host reaction (xgvhr) following injection in vivo was further studied in a newly developed animal model designed for preclinical evaluation of various biological response modifiers. f3 was injected intraven ...19883260961
fractionated extract of astragalus membranaceus, a chinese medicinal herb, potentiates lak cell cytotoxicity generated by a low dose of recombinant interleukin-2.success with ril-2 immunotherapy of human cancer appears to depend on the administration of high doses which are frequently associated with excessive toxicity. future use of ril-2 will require certain modifications based on the use of lower doses of ril-2 without significant loss of antitumor efficacy. we tested in vitro the possibility of potentiating the activity of ril-2 in terms of lak cell generation. we hypothesized that co-incubation of lak cell precursors with a chinese herbal extract (f ...19883264344
[synergism of astragalus membranaceus with interferon in the treatment of cervical erosion and their antiviral activities]. 19873319216
[changes in proteinuria, renal function and immunity after treatment with injections of a solution of astragalus membranaceus]. 19873690764
[the effect of the chinese medical herbs astragalus membranaceus and angelica sinensis on 3 kinds of experimental nephritis]. 19863743217
treating amenorrhea in vital energy-deficient patients with angelica sinensis-astragalus membranaceus menstruation-regulating decoction. 20133807414
[on the pharmacognosy of astragalus membranaceus tish (bge)]. 20145611766
[effects of astragalus membranaceus on enhancement of mouse natural killer cell activity]. 19836197202
[preliminary observation on the therapeutic effect of astragalus membranaceus in experimental anti-glomerular basement membrane nephritis in rabbits]. 19836227416
[effect of ph on hemolytic activity and stability of astragalus membranaceus injection]. 19846237759
[study on the biologically active constituents of astragalus membranaceus]. 19846237798
immune restoration and/or augmentation of local graft versus host reaction by traditional chinese medicinal herbs.the in vitro restorative effect of aqueous extracts from two traditional chinese medicinal herbs were studied in 19 cancer patients and in 15 normal healthy donors. using the local graft versus host (gvh) reaction as a test assay for t-cell function, the extract from astragalus membranaceus (10 microgram/ml) induced a restored reaction in nine of ten patients with an increase in local gvh reaction from 18.2 plus/minus 15.8 mm3 to 112.9 plus/minus 94.2 mm3 (p less than 0.01). the extract from lig ...19836336578
preliminary observations on the effects of the chinese medicinal herbs astragalus membranaceus and ligustrum lucidum on lymphocyte blastogenic responses.the biological effects of extracts of two chinese medicinal herbs, astragalus membranaceus and ligustrum lucidum, on in vitro lymphocyte blastogenesis were assessed. aqueous extracts augmented the spontaneous [3h]thymidine incorporation in the mononuclear cells (mnc) of 14 normal subjects from 273.0 to 609.3 counts per minute (cpm) and 252.9 to 656.9 cpm for the two herbs, respectively. the stimulation indices were 2.4 and 3.1, respectively (p less than 0.001). they also augmented the proliferat ...19836644339
[effect of astragalus membranaceus on t-lymphocyte subsets in patients with viral myocarditis].the efficacy of astragalus membranaceus (am) oral liquor combined with routine therapy and routine therapy alone on t-lymphocyte subsets of peripheral blood in viral myocarditis patients have been studied. the results showed that the t-lymphocyte subsets profile and okt4/okt8 ratio of peripheral blood were significantly lower in viral myocarditis patients than that in healthy control (p < 0.05, 0.01). routine therapy combined with am could significantly enhance okt3, okt4 and okt4/okt8 ratio in ...19957549379
[effects of astragalus membranaceus on left ventricular function and oxygen free radical in acute myocardial infarction patients and mechanism of its cardiotonic action].dynamic observations for 4 weeks were made on left ventricular function and oxygen free radical (ofr) in 43 patients first suffering from acute myocardial infarction and hospitalized in coronary care unit with an attack less than 36 hours. the results showed that the astragalus membranaceus (am) could strengthen the left ventricular function and had an effect of anti-ofr. after administration of am, the ratio of pre-ejection period/left ventricular ejection time (pep/lvet) was decreased, the sup ...19957647526
[comparison of effect of astragalus membranaceus and huoxuefang on thromboxane, prostacyclin and adenosine cyclic monophosphate in cerebral reperfusion injury in rabbits].the cerebral ischemia rabbit model was made by using the occlusion of four vessels. the results showed that txb2 and camp contents in brain tissues and the latter in plasma markedly increased (p < 0.05, p < 0.01), the 6-keto-pgf1 alpha in brain tissues significantly lowered (p < 0.05) in ischemia formed 30 minutes and 45 minutes after reperfusion. after intravenous injection of astragalus membranaceus (am) extracts (3.3 g/kg), huoxuefang (hxfo and yiqi houxue fang (yqhxf) consisted of am and hxf ...19957647534
[effect and mechanism of astragalus membranaceus on coxsackie b3 virus rna in mice].using balb/c mice infected with coxsackie virus b3 (cvb3) as a model, the effect of astragalus membranaceus (am) on cvb3-rna has been observed in myocardial tissues of mice by rna-rna in situ hybridization with negative-strand rna probes leballing with 35s and quantitative imaging analysis of positive hybridization signals. the mechanism of its effect on cvb3-rna has also been investigated by induction with am and detection of beta-interferon (beta-ifn). results showed that the copy numbers of c ...19947703635
[experimental studies on the effects of danggui buxue decoction on il-2 production of blood-deficient mice].danggui buxue decoction has shown the effect of significantly promoting the splenic capacity of blood-deficient mice in interleukin-2(il-2)production (p < 0.001). individual analysis of herbal formula has shown that il-2 production can be promoted in splenic lymphocytes of blood-deficient mice given angelica sinensis or astragalus membranaceus (p < 0.001).19947718137
[intervention of lidocaine and astragalus membranaceus on ventricular late potentials].16 and 22 patients with positive ventricular late potentials (lp) recorded on signal-averaged electrocardiograms (saecg) were treated with lidocaine 100 mg iv. or astragalus membranaceus 24 g iv. drip for 2 weeks respectively. as a result, the saecgs of 2 (12.5%) and 3 (13.6%) of them normalized respectively. compared with baseline, there were no significant changes in average hfqrsd, las and rms 40 after treatment of lidocaine. hfqrsd and las were shortened significantly 115.9 +/- 29.9 vs 125.1 ...19947719092
effects of compound injection of pyrola rotundifolia l and astragalus membranaceus bge on experimental guinea pigs' gentamicin ototoxicity.in attempting to find drugs effective in preventing and remedying ototoxic injury caused by aminoglycoside antibiotics, we relied on the theory that the induction of ototoxic injury by aminoglycoside antibiotics is related to a decrease of cyclic adenosine monophosphate and rna content in the cochlea or a dysfunction of the kidney. we selected pyrola rotundifolia l and astragalus membranaceus bge from traditional chinese herbal medicine, made a compound injection of them, and observed the effect ...19957747908
cycloartane triterpene glycosides from the hairy root cultures of astragalus membranaceus.agroastragaloside ii, a new astragaloside was isolated from the hairy root culture of astragalus membranaceus. its structure was established as 3-o-beta-(2'-o-acetyl)-d-xylopyranosyl-6-o-beta-d-glucopyranosyl-(24s)- 3 beta,6 alpha,16 beta,24,25-pentahydroxy-9,19-cyclolanostane on the basis of spectroscopic data. three known astragalosides, astragaloside ii, isoastragaloside i and 3-o-beta-d-xylopyranosyl-cycloastragenol were also isolated.19947765758
[effects of shi-ka-ron and chinese herbs in mice treated with anti-tumor agent mitomycin c].the shi-ka-ron, and its constituent chinese herbs lithospermum erythrorhizon, astragalus membranaceus and ligusticum wallichii were administered with antitumor agent, mitomycin c (mmc) to icr mice, and their effects on murine macrophages and lymphocytes were studied. peritoneal macrophages were significantly inhibited both in their number and chemotactic activity by mmc treatment. splenic weight and blastogenic responsiveness to concanavalin a of spleen lymphocytes also decreased significantly i ...19957787389
[clinical observation on the treatment of ischemic heart disease with astragalus membranaceus].92 patients suffering from ischemic heart disease was successfully treated with astragalus membranaceus (am). the effect of the treatment was compared with that of nifedipine and tab. salviae miltiorrhizae. the clinical practice showed that the group treated with am yielded better results. after having administered the drug, the patients were markedly relieved from angina pectoris (heart stroke). meanwhile the improvement of clinical objective index such as electrocardiogram (ekg) and impedance ...19957787395
chinese medicinal herbs inhibit growth of murine renal cell carcinoma.tumors are known to produce factors suppressing immune functions. we previously showed that a murine renal cell carcinoma (renca) suppressed macrophage function in vitro and that this suppression was abolished by co-incubation with extracts of two chinese medicinal herbs. we now report that these phytochemicals are capable of inhibiting growth of renca in vivo. balb/c mice were transplanted intraperitoneally (ip) with 1-2 x 10(5) renca cells. one day after tumor transplant, mice were randomized ...19947812364
[non-surgical treatment of small cell lung cancer with chemo-radio-immunotherapy and traditional chinese medicine].54 consecutive cases of small cell lung cancer (sclc) were treated with longterm short-interval combined treatment modalities of chemotherapy, radiotherapy (55-65 gy), immunotherapy, traditional chinese medicine (leaf of asiatic ginseng, root of astragalus membranaceus bge, etc) and other adjuvants. chemotherapy consisted of vincristine, cyclophosphamide, methotrexate and carmustine. a complete response of 59.2%, partial response of 38.9% and an overall response of 98.1% were achieved. according ...19947867442
[memory-improving effect of aqueous extract of astragalus membranaceus (fisch.) bge].the study shows that the aqueous extract of astragulus membranaceus (amwe) can improve the anisodine-induced impairment on memory acquisition as well as the alcohol-elicited deficit of memory retrieval (number of errors were reduced and latent period was prolonged) in step down, and can also prolong the gasping duration of mice after decapitation at doses of 50g/kg (ig) for 7 days.19947893391
[effect of jian yan ling on serum lipids, apoprotein and lipoprotein-a].effect of jian yan ling (jyl, mainly consisted of succinum, pteria margaritifers and astragalus membranaceus etc.) on serum lipids was studied by double-blind method in 128 hyperlipemia patients. patients were divided randomly into two groups, the test groups (64 cases) treated with jyl, while the other 64 cases treated with placebo as control for 3 months. serum total cholesterol (tc), triglyceride (tg), tc-high density lipolipid-cholesterol (tc-hdl-c), apoproteins were observed before and afte ...19947950180
[action of astragalus membranaceus on left ventricular function of angina pectoris].the action on left ventricular function of astragalus membranaceus (am), a qi-tonic, in 20 patients with angina pectoris was studied by means of doppler echocardiogram (dec). it showed that cardiac output increased from 5.09 +/- 0.21 to 5.95 +/- 0.18 l/min 2 weeks after am was administered (p < 0.01), and no improvement of left ventricular diastolic function appeared. adenosine triphosphatase activity was not inhibited by using am, which was different from that of digitalis.19947950192
[clinical study of baoyuan dahuang decoction in the treatment of chronic renal failure].the quality of life of 56 chronic renal failure (crf) patients using two kinds of treatment has been observed. 36 of them were taken as group a with bun 21.62 +/- 5.96 mmol/l, cr 528.63 +/- 176.3 mumol/l and hb 65 +/- 13 g/l were treated with baoyuan dahuang decoction consisted of panax ginseng, astragalus membranaceus, cassia cinnamomi, glycyrrhiza uralensis and rheum palmatum. result: six symptoms were observed, that were: fatigue, lassitude in loin and legs, aversion of cold, anorexia, sexual ...19947950208
[effect of astragalus membranaceus on electrophysiological activities of acute experimental coxsackie b3 viral myocarditis in mice].a murine model for observing the effect of astragalus membranaceus (am) on electrophysiological activity of the right ventricular myocardium was developed in 4 week-old male balb/c mice infected with coxsackie b3 virus (cb3v). the conventional microelectrode technique and real-time microcomputer data processor system was used. the survival rate in infected-am treated mice was significantly higher and the percentage of abnormal action potential was much lower than those in control mice (p < 0.05 ...19947950216
[the in vitro potentiation of lak cell cytotoxicity in cancer and aids patients induced by f3--a fractionated extract of astragalus membranaceus].the in vitro induction of lak cell activity was studied in cancer and aids patients. f3, an immuno-regulatory component of astragalus membranaceus was shown capable of potentiating the lak cell inducing activity of ril-2. the killing activity against hs294t melanoma cell line of lak cells induced by 50 u/ml ril-2 in the presence of f3 (55 micrograms/ml) reached 64% which was comparable to that (60%) induced by 500 u/ml of ril-2 alone. with f3 plus ril-2, the effector to target cell ratio could b ...19947956691
[effects of the combination of astragalus membranaceus (fisch.) bge. (am), tail of angelica sinensis (oliv.) diels. (tas), cyperus rotundus l. (cr), ligusticum chuanxiong hort. (lc) and paeonia veitchii lynch (pv) on the hemorrheological changes in normal rats].the results showed that am and tas had significant effects of enriching the blood. cr, a qi-regulating drug, lc and pv, two blood-activating drugs, could improve all hemorrheological indexes, such as the whole blood specific viscosity, the plasma specific viscosity, erythrocyte electrophoresis, etc. the combination of qi-regulating drug and blood-activating drug displayed more favorable effect. this experiment has provided some pharmacological evidence for the theory of "qi xue xiang guan" (corr ...19938003220
[effects of the combination of astragalus membranaceus (fisch.) bge. (am), angelica sinensis (oliv.) diels (tas), cyperus rotundus l. (cr), ligusticum chuangxiong hort (lc) and peaonìa veitchii lynch (pv) on the hemorheological changes in "blood stagnating" rats].the "blood stagnating" rat model was built with adrenaline and cold stimulation. its hemorrheological character was an increase in the viscosity, thickness and liability to coagulate. the experimental result showed that am and tas could decrease the whole blood specific viscosity, but at the same time increase the plasma specific viscosity. the qi-regulating drug cr and two blood-activating drugs lc and pv could improve the hemorrheological changes in "blood stagnating" rats. the combination of ...19948011132
astragalus membranaceus and polygonum multiflorum protect rat heart mitochondria against lipid peroxidation.we isolated rat heart mitochondria and induced lipid peroxidation with adp and feso4. oxygen consumption and mda formation were measured for quantitating the amount of lipid peroxidation. using these methods, we screened the water extracts of 14 chinese medicinal herbs for their effect on lipid peroxidation. it was found that astragalus membranaceus inhibited 42.1 +/- 3.4% of oxygen consumption and 39.8 +/- 3.2% of mda production at concentration of 2 mg dried herb/ml mitochondrial suspension. a ...19948030620
effect of astragalus membranaceus on electrophysiological activities of acute experimental coxsackie b-3 viral myocarditis in mice.a murine model for observing the effect of astragalus membranaceus (am) on electrophysiological action of the right ventricular myocardium was developed in 4-week-old male balb/c mice infected with coxsackie b-3 virus (cb3v). the conventional microelectrode technique and a real-time data processor system were used. the survival rate in am-treated mice was much higher and the percentage of abnormal action potential was much lower than those in infected control mice (p < 0.05, p < 0.01, respective ...19938032064
[positive modulating action of shengmaisan with astragalus membranaceus on anti-tumor activity of lak cells].enhancing the anti-tumor activity of lak cells is one of problems which are expected to be solved in tumor clinic at present. the effects of shengmaisan with astragalus membranaceus (smam) on anti-tumor activity of lak cells with the 3h release assay were studied. the lak cells taken from 43 persons showed obvious killing activity to acute leukemia cells from 8 patients in different types. the results showed that the activity of lak cells could be enhanced markedly by the synergic action of smam ...19938111199
[effect of improving memory and inhibiting acetylcholinesterase activity by invigorating-qi and warming-yang recipe].invigorating-qi and warming-yang (iqwy) had a good curative effect to some senile diseases such as senile dementia, senile hypomnesia etc. this experiment was designed for probing into the therapeutical mechanism of iqwy recipe. balb/c pure bred mice were divided into five groups. group i was taken per os of invigorating qi (iq), group ii warming yang (wy), group iii iqwy drugs, group iv was dysmnesia model, and group v blank control group injected with normal saline only. all groups except grou ...19938155947
[effect of astragalan on secretion of tumor necrosis factors in human peripheral blood mononuclear cells].the extracts of astragalus membranaceus have been further isolated by liquid chromatography. one of the fractions (astragalan, m.w. 20,000-25,000) could enhance the secretion of tumor necrosis factor (tnf) from human peripheral blood mononuclear cells (pbmc) in vitro. after isolation of adherent and nonadherent mononuclear cells from pbmc, astragalan increased the secretion of tnf-alpha and tnf-beta respectively. these results suggest further study of astragalan would promote the application of ...19938219673
[effect of astragalus membranaceus on cardiovascular system]. 19938251732
[clinical and experimental studies of effects of huayu decoction on scavenging free radicals].infantile pneumonia has been treated successfully with huayu decoction (hyd) in our department for more than ten years. according to the principles of huoxue huayu of tcm, the composition of huayu decoction is as follows: angelica sinensis, paeonia lactiflora, ligusticum wallichii, spathollobus suberectus, hirudo nipponica, tabanus bivittatus, paeonia suffroticosa, astragalus membranaceus . 49 cases of infantile pneumonia were treated with hyd. the activity of erythrocyte superoxide dismutases ( ...19938312693
[clinical and experimental study on yi-gan-ning granule in treating chronic hepatitis b].this paper reports that 320 patients with chronic hepatitis b (chb) were treated with yi-ganning granule (ygng) and the pharmacodynamics of ygng in the animal study. as control, another 70 patients with chb receiving oleanolic acid granule (oag) were compared to 68 patients in ygng group. ygng is consisted of astragalus membranaceus , artemisia capillaris, codonopsis pilosula, et al. each patient has taken ygng or oag for 3 months. the result showed ygng was effective on recovering the liver fun ...19938312695
[effect of astragalus membranaceus on myoelectric activity of small intestine].astragalus membranaceus (am) is one of the important chinese medicinal herbs which are widely used and well known for its invigoration of vital energy. in the present experiment, the cycle duration of interdigestive myoelectric complex (idmec) and the durations of every phase were observed electrophysiologically before and after the 25% concentrated solution (1 ml/kg) was instilled into the empty stomach of the healthy, awakened dog. signals of idmec were recorded by microcomputer. no significan ...19938312701
[effects of exercise in the growing stage in mice and of astragalus membranaceus on immune functions].a study was carried out to examine the effects of forced running exercise in the growing stage in male icr mice and of astragalus membranaceus (as) on their immune functions. the mice were divided at 4 weeks of age into 4 groups. the first group of mice received forced running exercise (e-group), the second group was given as (as-group), the third group received the forced running exercise and was given as (e+as-group) and the fourth group was a control receiving no treatment. the exercise recei ...19938388067
the inhibitory effect of astragalus membranaceus on coxsackie b-3 virus rna replication.using mice infected with coxsackie b-3 virus (cvb3) as a viral myocarditis model, we observed the inhibitory effect of astragalus membranaceus (am) on cvb3-rna replication in myocardial tissue of mice by rna-rna in situ hybridization with negative-strand rna probes labelled with 35s and quantitative imaging analysis of positive signals. the mechanism of its effect on cvb3-rna replication has been investigated by detection of beta-interferon (beta-ifn) as well. results showed that the copy number ...19958580483
[clinical and experimental study on inhibitory effect of sanhuang mixture on platelet aggregation].sanhuang mixture (xinmai capsule) is composed of astragalus membranaceus, coptis chinensis and scutellaria baicalensis. it could inhibit platelet aggregation (pag) induced by adp in rats or by adp and adr in vivo. patients with high pag took xinmai capsule for 4 weeks, the effective rate was 88.7%, which was same as the efficacy of aspirin 50 mg/day. in syndrome differentiation of tcm, the effective rate was the highest (92.3%) in the syndrome of qi deficiency-blood stasis, and the lowest (72.7% ...19958580692
[effect of astragalus membranaceus on ca2+ influx and coxsackie virus b3 rna replication in cultured neonatal rat heart cells].the effect of astragalus membranaceus (am) on ca2+ influx across the myocardial plasma membrane and coxsackie virus b3(cvb3)-rna replication in cultured neonatal rat heart cells infected with cvb3 was investigated. it was found that the ca2+ influx could be inhibited significantly (p < 0.01) by am after infection of heart cells for 48 h. in addition, when the cultured heart cells infected with cvb3 and treated with am for 48 h, the ca2+ influx of infected heart cells also could be inhibited by a ...19958580697
[nuclear cardiology study on effective ingredients of astragalus membranaceus in treating heart failure].the experimental study has testified that among the various effective constituents gained from astragalus membranaceus (am) is the main component. nineteen patients with heart congestive failure were treated with effective ingredient of am, the astragaloside iv (xga) injection.19958732134
extract of astragalus membranaceus and ligustrum lucidum does not prevent cyclophosphamide-induced myelosuppression.there is increasing evidence that many chinese medicinal herbs are promising biological response modifiers in cancer treatment. the extract of some chinese herbs have shown ability in stimulating the bone marrow and improving the peripheral white cell counts in rats. we studied the effect of a dried extract of two commonly used chinese herbs, astragalus membranaceus (am) and ligustrum lucidum (ll) on cytotoxic-induced myelosuppression. wistar rats weighing 250-300g each were divided into two gro ...19958919152
regulation of the fibrinolytic potential of cultured human umbilical vein endothelial cells: astragaloside iv downregulates plasminogen activator inhibitor-1 and upregulates tissue-type plasminogen activator expression.we have investigated whether the saponin astragaloside iv (as-iv), a 3-o-beta-d-xylopyranosyl-6-o-beta-d-glucopyranosylcycloastragenol, purified from the chinese herb drug astragalus membranaceus, which is used in traditional chinese medicine to treat cardiovascular diseases, might affect the fibrinolytic potential of cultured human umbilical vein endothelial cells (huvecs). when huvecs were conditioned with as-iv, a dose (0.01-100 microg as-iv/ml)- and time-dependent decrease in plasminogen act ...19979256087
immunomodulating activity of chinese medicinal herbs and oldenlandia diffusa in particular.the effect of eight different chinese medicinal herbs (cmhs) on lymphocytes was studied in vitro using murine spleen cells. among the studied eight cmhs, astragalus membranaceus and oldenlandia diffusa markedly stimulated murine spleen cells to proliferate. the responder cells for cmhs were b cells, because the response was depleted by the treatment of spleen cells with anti-immunoglobulin (i.g.) antibody and complement and after purification by nylon wool column. this response was not due to co ...19979568540
[a study on combination therapy of western and traditional chinese medicine of acute viral myocarditis].to investigate the combination therapy of western and traditional chinese medicine on treatment of acute viral myocarditis, 48 patients were randomly divided into 2 groups. the 1st group consisted of 30 patients, receiving the combination therapy of western and traditional chinese medicine, including astragalus membranaceus, taurine, coenzyme q10 and antiarrhythmics, while the 2nd group consisted of 18 patients, receiving the conventional therapy, including glucose-insulin-potassium (gik), coenz ...19969772585
determination of the components in a chinese prescription, yu-ping-feng san, by rapd analysis.in this study, the rapd (random amplified polymorphic dna) technique was employed for the first time to determine the components in a chinese herbal prescription. forty decamer oligonucleotide primers were screened in the rapd analysis to identify three chinese medicines, the dried root of astragalus membranaceus (fisch.) bge., the dried root of ledebouriella seseloides wolff, and the dried rhizome of atractylodes macrocephala koidz, in a chinese prescription. only primer opp-10 simultaneously g ...19989776663
botanical influences on cardiovascular disease.several botanicals, including crataegus oxycantha, terminalia arjuna, inula racemosa, and astragalus membranaceus, have been found to have therapeutic benefit for the treatment of cardiovascular disease. crataegus oxycantha has been used traditionally as a cardiac tonic and current uses include treatment for angina, hypertension, arrhythmias, and congestive heart failure. animal studies have also indicated that crataegus extracts may also have potential use as anti-ischemic and lipid-lowering ag ...19989855567
the protective effects of traditional chinese medicine prescription, han-dan-gan-le, on ccl4-induced liver fibrosis in rats.han-dan-gan-le, a chinese medicine preparation composed of salvia miltorrhiza, radix paeoniae, astragalus membranaceus, stephania tetrandra, and dried leaves of ginkgo biloba, has been used successfully to treat human liver fibrosis and cirrhosis for years. this study was designed to examine the mechanisms of the protection. male wistar rats were given ccl4 (1.2 ml/kg, 2 times/week), 20% fat diet, and 30% alcohol in drinking water (every other day) for 6 weeks. han-dan-gan-le (0.5 and 1.0 g/kg, ...19989862020
studies on chemical constituents and immunological function activity of hairy root of astragalus membranaceus.using a large-scale culture technique, the hairy roots of astragalus membranaceus were produced with a yield reaching 10 g/l. the results from rp-hplc detection showed that the contents of crude saponin and astragaloside i.v. in the hairy roots were 5.81% and 0.14%, respectively. six isoflavonoid compounds were also determined. polysaccharide analysis showed that the total polysaccharide content in the hairy roots was 22.97%; of this content, acidic 8.29% and soluble 14.88%. in comparison with t ...199810196633
antidotal effect of glucoside extracted from astragalus membranaceus on dimethoate intoxication in guinea pigs.therapeutic effect of the glucoside extracted from the root of astragalus membranaceus (am) was studied in guinea pigs intoxicated with 600 mg/kg doses of dimethoate (d). four groups of guinea pigs, each consisting of two males and two females, were treated with (a) d, (b) d + atropine, and (c) d + am, (d) d + atropine + am. the survival time of the animals increased from an average of 70 minutes without am to an average of 235 minutes with am. severe changes in ecg were observed prior to respir ...199810217935
mechanisms of the therapeutic effect of astragalus membranaceus on sodium and water retention in experimental heart failure.to investigate the therapeutic effect of astragali on sodium and water retention in aortocaval fistula-caused experimental congestive heart failure and its involved mechanisms.199810322646
myocardial protection against ischaemia-reperfusion injury by a polygonum multiflorum extract supplemented 'dang-gui decoction for enriching blood', a compound formulation, ex vivo.'dang-gui decoction for enriching the blood' (be), a traditional chinese formulation comprising angelica sinensis and astragalus membranaceus, is used for stimulating red blood cell production as well as enhancing cardiovascular function. in the present study, we have demonstrated the myocardial protection afforded by be pretreatment against ischaemia-reperfusion (ir) injury in isolated-perfused rat hearts. a more complete and potent myocardial protection against ir injury was also shown by a po ...200010815014
inhibitory effects of astragali radix, crude drug in oriental medicines on lipid peroxidation and protein oxidative modification of mouse brain homogenate by copper.astragali radix, the root of astragalus membranaceus bunge, is a crude drug used widely in oriental medicines. it is a major component of ougi-keishi-gomotsu-to, a traditional herbal medicine, used for neurop patients with abnormal sensations and neuropathic pain of the legs. it was shown to have inhibitory effects on lipid peroxidation and protein oxidative modification by copper. the effects were similar to and stronger than those of mannitol and superoxide dismutase as free radical scavengers ...200010861978
species identification of radix astragali (huangqi) by dna sequence of its 5s-rrna spacer domain.about 300 species and varieties of astragalus are identified in china, making the identification of the origin of a particular astragalus species on the consumer market difficult. a molecular genetic approach was developed to identify various species of astragalus. although the 5s-rrna coding sequence is conserved in higher eukaryotes, the spacer domain of the 5s-rrna gene has great diversity among different species. the 5s-rrna spacer domain was amplified by polymerase chain reaction (pcr) from ...200010897476
rapd analysis of astragalus medicines marketed in taiwan.the genetic variability of astragalus medicine materials sold by twenty randomly selected stores in taiwan was investigated using rapd analysis in order to obtain available primers which could clearly differentiate among them. total dna isolated from the rhizomes of the samples were used as templates, and sixty 10 mer arbitrary primers were used in the analysis. the aim of the present study is to construct an identification model of molecular biotechniques applicable to chinese herbal medicines ...200010999446
[the effect of herbal medicine including astragalus membranaceus (fisch) bge, codonpsis pilosula and glycyrrhiza uralensis fisch on airway responsiveness].to study the effect of astragalus membranceus(fisch) bge, codonpsis pilosula and glycyrrhiza uralensis fisch on airway responsiveness.199811326953
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