Publications

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[ostracod, eucypris infiata, the intermediate host of avian cestodes in the biocenosis of lake tengiz].in the biocoenosis of the lake tengiz (central kazakhstan) eucypris inflata (0.3--11%) was found to be spontaneously infected with the larvae of cestodes-hymenolepidids (6 species) and dilepidids (1 species). the nesting flamingos and moulting grebes from the same water body were also infected to a great extent with these cestodes. figures and morphological description of cysticercoids (7 species) and skolex of mature cestodes of parabiglandatrium phoenicopteri are given.2007149938
mycobacteriosis in the lesser flamingos of lake nakuru, kenya.in 1974, 51 debilitated lesser flamingos (phoeniconaias minor) were easily captured at lake nakuru, kenya. nineteen (37%) of these had extensive mycobacterial lesions. two years later it was difficult to locate any debilitated flamingos and no evidence of mycobacterial infection was found. possible reasons for the high prevalence of mycobacteriosis in the 1974 collection are discussed.1979501841
hypothetical stages in the evolution of modern ducks and flamingos. 1977904341
cutaneous geotrichosis in the red flamingo (phoenicopterus ruber).in three flamingos (phoenicopterus ruber), which died showing extensive necrotic inflammation of the skin of the webs and the legs, the presence of abundant mycelium and arthrospores was shown in the altered dermis and epidermis. from all the lesions geotrichum candidum was isolated in pure culture. inoculation of suspensions of the fungus into domestic chickens and mice produced granulomas or more purulent nodules with central growth of abundant mycelium. from 20 of 28 experimental animals, g. ...19761265572
highly repeated dna sequences in birds: the structure and evolution of an abundant, tandemly repeated 190-bp dna fragment in parrots.up to 6.8% of the parrot (psittaciformes) genome consists of a tandemly repeated, 190-bp sequence (p1) located in the centromere of many if not all chromosomes. monomer repeats from 10 different psittacine species representing four subfamilies were isolated and cloned. the intraspecific sequence variation ranged from 1.5 to 7%. the interspecific sequence variation ranged from less than 3% between two species of cockatoos to approximately 45% between cockatoos and other parrots. the monomer seque ...19921339392
laparoscopic salpingectomy in a hybrid flamingo. 19921441148
amyloidosis, hemochromatosis, and atherosclerosis in a roseate flamingo (phoenicopterus ruber).an aged male roseate flamingo, in a private collection in the british virgin islands, was found acutely "down." after four days of supportive therapy, the flamingo succumbed. at necropsy gross lesions included emaciation; collapsed and thickened, yellow abdominal air sac; dark red liver, partially covered by friable yellow material; and a raised, intimal plaque in the aorta near the iliac trifurcation. histologic examination revealed severe, diffuse, pyogranulomatous air sacculitis with associat ...19921626869
cutaneous tumour-like lesions due to poxvirus infection in chilean flamingos.cutaneous tumour-like growths were observed on the face and other areas of the body surface of young chilean flamingos. in the cells of these lesions, avian pox-specific cytoplasmic inclusion bodies were observed by light microscopy and virus particles were detected under an electron-microscope. it was diagnosed as avian pox.19911651962
metabolism of carotenoid pigments in birds.carotenoid pigments are an important component in the plumage of birds. the metabolic precursors are dietary in origin but many species have the capacity to chemically modify and selectively deposit the pigments. the ensuing plumage patterns are important in communication and identification. the bright yellows, oranges, and reds are due mostly to xanthophylls; keto and hydroxy carotenes. some are deposited unmodified (e.g., lutein) whereas others are modified chemically (canthaxanthin, astaxanth ...19902394316
immunohistochemical characterization of spontaneous amyloidosis in captive birds as aa-type, using monoclonal and polyclonal anti-aa antibodies against mammalian amyloid.spontaneous amyloid diagnosed by means of congo red and polarization microscopy in 3 flamingos, 1 crowned crane, 1 red-breasted goose, and 1 common golden-eye was studied using immunohistochemical techniques. the avian amyloid cross-reacted with a number of monoclonal and polyclonal anti-aa antibodies directed against mammalian amyloid fibril proteins. this confirmed that both "secondary" and "idiopathic" avian amyloid is of the aa-type. the results demonstrate the possibility to successfully us ...19892505480
a serological survey of toxoplasma gondii infection in zoo animals and other animals.a survey for toxoplasma gondii (tp) infection in the animals bred or caught in and around kobe municipal oji zoo was conducted by the latex agglutination (la) test using plasma samples collected for the years from 1980 to 1988. plasma antibody to tp (greater than or equal to 1:64) was found in 5.0% (0 of 181) mammals belonging to 28 families of 10 orders and 6.7% (12 of 179) aves belonging to 22 families of 15 orders, respectively. cats, rats and pigeons caught in and around the zoo lower positi ...19892607744
trace elements in little egrets and flamingos of camargue, france.trace elements (cd, cu, hg, pb, se, zn) were measured in nine organs (liver, kidney, breast muscle, lungs, breastbone, stomach, gizzard, spleen, feathers) of several specimens of greater flamingos (phaenicopterus ruber (pallas] and little egrets (egretta garzetta (l.] from the camargue, in the rhône river delta. in both species, individual fluctuations of cd, hg, pb, and se levels were important in all organs, whereas zn and cu, essential metals, exhibited only moderate variations. the organotro ...19883359952
[organ enzyme patterns and plasma enzyme activities in the chicken, ostrich and flamingo]. 19863775347
[the mating behavior of the flamingo genus phoenicopterus, with special reference to ph. ruber roseus]. 19744467664
infection with the nematode streptocara incognita in the chilean flamingo. 19744810219
[some mucormycoses of cattle, swine, cat, deer, and the flamingo]. 19675629476
exceptional carotenoid metabolism in the andean flamingo. 19655836326
comparative metabolic fractionation of carotenoids in three flamingo species. 19665943916
carotenoid selectivity in blood and feathers of lesser (african), chilean and greater (european) flamingos. 19676075163
drug resistance and r plasmids in escherichia coli strains isolated from imported pet birds.drug resistance in escherichia coli strains isolated from pet birds (mynahs, macaws, finches, common bengals, parrots, and flamingos) imported into japan from 10 foreign countries in 1977 and 1978 was investigated. of the 309 strains isolated from 127 pet birds in the animal quarantine service, 232 (75.1%) were drug resistant. furthermore, strains resistant to oxytetracycline hydrochloride, dihydrostreptomycin, and sulfadimethoxine were relatively common. resistance patterns varied from single t ...19806163947
the amino-acid sequence of alpha a- and beta-chains from the major hemoglobin component of american flamingo (phoenicopterus ruber ruber).the complete amino-acid sequence of alpha a- and beta-chains from the major hemoglobin component (hba) of american flamingo ( phoenicopterus ruber ruber) is presented. the minor component (hbd) with alpha d-chains was detected in similar amounts (25%) as in chicken and pheasant hemoglobins. the comparison of american flamingo and greylag goose (anser anser) hemoglobins shows that alpha a-chains differ by 22 exchanges and beta-chains by only 4 exchanges. two substitutions modify alpha 1 beta 1-co ...19846735355
flamingo forceps for use in microscopic antrostomy.the flamingo forceps is an upbiting cup forceps with an angulated shaft of 7 3/8 in for use in the maxillary sinus using the operating microscope. the design is such that the surgeon's hand is not in the line of vision and the instrument can be used on the right or left side and in various directions.20176787511
intestinal microflora of young greater flamingos (phoenicopterus ruber roseus pallas) in the camargue. 19836842737
[mycobacteria in the digestive tract of pink flamingos (phoenicopterus ruber roseus, pallas)].cloacal swabs were taken from 37 young wild greater flamingos (phoenicopterus ruber roseus, pallas) in camargue (south of france). neither pathogenic strain, nor environmental one were found. the absence of the latter could be attributed to the high nacl levels of the ecosystems.19817296738
[artemia sp. (crustacea, anostracea) as intermediate host of eurycestus avoceti clark, 1954 (cestoda, cyclophyllidea) (author's transl)].examination of artemia sp. (crustacé, anostracé) for natural infection by cysticercoids of flamingolepis liguloides, cestode of the flamingo (phoenicopterus ruber) shows the presence of three other cysticercoids of cestode parasites of the flamingo in the hemocoele of the branchiopode. a fourth one is reported as the cysticercoid of eurycestus avoceti, clark, 1954, which parasitizes the avocet (recurvirostra avosetta). the systematic position of this cestode is always unknown. this report shows ...20067406422
fatness and physical fitness of girls 7 to 17 years.a two-fold approach was used to investigate the association between fatness and fitness of girls 7 to 17 years of age: first, age-specific correlations between fatness and measures of health-related and motor fitness, and second, comparisons of fitness levels of girls classified as fat and lean. a representative sample of 6700 between 7 to 17 years was surveyed. adiposity (fatness) was estimated as the sum of five skinfolds (biceps, triceps, subscapular, suprailiac, medial calf). physical fitnes ...19957627770
the walk of a flamingo. 19957761637
sequence conservation of an avian centromeric repeated dna component.the approximately 190-bp centromeric repeat monomers of the spur-winged lapwing (vanellus spinosus, charadriidae), the chilean flamingo (phoenicopterus chilensis, phoenicopteridae), the sarus crane (grus antigone, gruidae), parrots (psittacidae), waterfowl (anatidae), and the merlin (falco columbarius, falconidae) contain elements that are interspecifically highly variable, as well as elements (trinucleotides and higher order oligonucleotides) that are highly conserved in sequence and relative l ...19948034177
what parameters can be used for individual acoustic recognition by the greater flamingo?the greater flamingo phoenicopterus ruber is a colonial bird for which acoustic communication plays a great role, in particular during the mating period. the study of contact calls emitted by the adults allow enables identification of some acoustic parameters which may be used for individual recognition. it appears that the frequential values of the harmonics, the distribution of energy in the spectrum as well as beats (mimicking amplitude modulations) are susceptible to represent individual mar ...19968673616
[sarcocystis phoeniconaii n. sp. murata, 1986 (apicomplexa: sarcocystidae) of the lesser flamingo (phoeniconaias mirror: ciconiiformes)].the tiny rice-grain like sarcocysts measure 3-5 x 1 mm, they are situated subfascially or in the depth of the muscles. the 50 nm thick irregular primary cyst wall forms towards the inside, small, bubble-like, less osmiophilic invaginations, which partly are concentrated in such a way, that a spongious like structure develops. the so surrounded protrusions are vertically or slightly inclined; they measure 4.25 x 1.7 microns and they are filled with compact fibrils. the cyst wall is underlaid by a ...20068765541
genetic relatedness amongst intestinal spirochaetes isolated from rats and birds.multilocus enzyme electrophoresis was used to determine genetic relationships amongst 32 intestinal spirochaetes (serpulina spp.) isolated from rats (17), rheas (7), chickens, (4), ducks (2), a swan (1) and a flamingo (1). the strains were divided into 20 electrophoretic types (ets), with a mean genetic diversity per locus of 0.62. the results were compared with those previously published for porcine intestinal spirochaetes. one strain from a healthy rat, and three rhea strains which were recove ...19968987903
an epizootic of lead poisoning in greater flamingos (phoenicopterus ruber roseus) in spain.during november 1992 to march 1993, and november 1993 to february 1994, 106 greater flamingos (phoenicopterus ruber) were collected dead or moribund in the wetlands of el fondo and salinas de santa pola, eastern spain. birds still alive were emaciated and had a bile-stained diarrhea. on necropsy, they had liquid in the upper digestive tract and the walls of their gizzards were stained dark green. fifty-three (93%) of 57 gizzards examined contained lead shot (range one to 277 shot), and fifty-fiv ...19979027700
mosquito (aedes taeniorhynchus) resistance to methoprene in an isolated habitat.salt-marsh mosquitoes (aedes taeniorhynchus), collected on 2 barrier islands in lee county, florida, that had been treated from 1989 to 1994 with 150-day methoprene briquets, were bioassayed with technical s-methoprene in the laboratory. susceptibility of the indigenous captiva strain (median lethal concentration [lc50] estimate, 6.71 ppb) collected from captiva island was 14.9-fold lower than the naive flamingo strain (lc50 estimate, 0.45 ppb) from everglades national park. the lover's key stra ...19989673923
pink flamingo gloves. 199310125771
mycobacterium avium-related epizootic in free-ranging lesser flamingos in kenya.an epizootic in free-ranging lesser flamingos (phoeniconaias minor) in kenya resulted in more than 18,500 deaths from august through mid-november 1993. disease was concentrated along the shores of rift valley lakes bogoria and nakuru (kenya) and did not involve any of the other avian or mammalian species frequenting the lakes. coincidental to the outbreak was a bloom of algae on lake bogoria, toxins from which were first suspected to be causative. discrete necrotic and granulomatous lesions were ...199910231756
flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of frizzled.we identified a seven-pass transmembrane receptor of the cadherin superfamily, designated flamingo (fmi), localized at cell-cell boundaries in the drosophila wing. in the absence of fmi, planar polarity was distorted. before morphological polarization of wing cells along the proximal-distal (p-d) axis, fmi was redistributed predominantly to proximal and distal cell edges. this biased localization of fmi appears to be driven by an imbalance of the activity of frizzled (fz) across the proximal/dis ...199910490098
genes regulating dendritic outgrowth, branching, and routing in drosophila.signaling between neurons requires highly specialized subcellular structures, including dendrites and axons. dendrites exhibit diverse morphologies yet little is known about the mechanisms controlling dendrite formation in vivo. we have developed methods to visualize the stereotyped dendritic morphogenesis in living drosophila embryos. dendrite development is altered in prospero mutants and in transgenic embryos expressing a constitutively active form of the small gtpase cdc42. from a genetic sc ...199910521399
flamingo controls the planar polarity of sensory bristles and asymmetric division of sensory organ precursors in drosophila.the sensory bristles of the fruit fly drosophila are organized in a polarized fashion such that bristles on the thorax point posteriorly. these bristles are derived from asymmetric division of sensory organ precursors (sops). the numb protein, which is localized asymmetrically in a cortical crescent in each sop, segregates into only one of the two daughter cells during cell division, thereby conferring distinct fates to the daughter cells [1] [2]. in neuroblasts, establishment of apical-basal po ...199910556092
origin of the west nile virus responsible for an outbreak of encephalitis in the northeastern united states.in late summer 1999, an outbreak of human encephalitis occurred in the northeastern united states that was concurrent with extensive mortality in crows (corvus species) as well as the deaths of several exotic birds at a zoological park in the same area. complete genome sequencing of a flavivirus isolated from the brain of a dead chilean flamingo (phoenicopterus chilensis), together with partial sequence analysis of envelope glycoprotein (e-glycoprotein) genes amplified from several other species ...199910600742
a new design metal stent (flamingo stent) for palliation of malignant dysphagia: a prospective study. the rotterdam esophageal tumor study group.metal stents are not superior to conventional endoprostheses with respect to the incidence of recurrent dysphagia because of tumor ingrowth with uncovered stents and migration with their covered counterparts. to overcome these limitations, a partially covered (inside-out covering) metal stent with a conical shape and a varying braiding angle of the mesh along its length, the flamingo stent, has been developed.200010650254
large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.recent studies revealed a striking difference in the genomic organization of classic cadherin genes and one family of "nonclassic cadherin" genes designated protocadherins. specifically, the dna sequences encoding the ectodomain repeats of classic cadherins are interrupted by multiple introns. by contrast, all of the encoded ectodomains of each member of the protocadherin gene clusters are present in one large exon. to determine whether large ectodomain exons are a general feature of protocadher ...200010716726
phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.cadherins play an important role in specific cell-cell adhesion events. their expression appears to be tightly regulated during development and each tissue or cell type shows a characteristic pattern of cadherin molecules. inappropriate regulation of their expression levels or functionality has been observed in human malignancies, in many cases leading to aggravated cancer cell invasion and metastasis. the cadherins form a superfamily with at least six subfamilies, which can be distinguished on ...200010835267
osteitis pubis and instability of the pubic symphysis. when nonoperative measures fail.seven rugby players with osteitis pubis and vertical instability at the pubic symphysis were treated operatively after nonoperative treatment had failed to improve their symptoms. the vertical instability was diagnosed based on flamingo view radiographs showing greater than 2 mm of vertical displacement. the players had undergone at least 13 months of nonoperative therapy before surgery was considered. operative treatment consisted of arthrodesis of the pubic symphysis by bone grafting supplemen ...201710843126
cestodiasis with intestinal diverticulosis in a lesser flamingo (phoeniconaias minor).an adult female lesser flamingo (phoeniconaias minor), caught in the african rift valley in 1991 and subsequently housed at the baltimore zoo, died of severe visceral gout in 1996. necropsy revealed a white, moderately firm, nodular lesion, 1 cm in diameter, in the serosal wall of the small intestine. although it was initially thought to be a tumor or focal granuloma, histologic examination revealed multiple cestodes deeply embedded at the base of the crypts between the intestinal villi, with th ...200010884133
the human homologue of flamingo, egfl2, encodes a brain-expressed large cadherin-like protein with epidermal growth factor-like domains, and maps to chromosome 1p13.3-p21.1. 200010907856
dentritic growth: don't go says flamingo. 200011086974
control of dendritic field formation in drosophila: the roles of flamingo and competition between homologous neurons.neurons elaborate dendrites with stereotypic branching patterns, thereby defining their receptive fields. these branching patterns may arise from properties intrinsic to the neurons or competition between neighboring neurons. genetic and laser ablation studies reported here reveal that different multiple dendritic neurons in the same dorsal cluster in the drosophila embryonic pns do not compete with one another for dendritic fields. in contrast, when dendrites from homologous neurons in the two ...200011086986
patterning of cell assemblies regulated by adhesion receptors of the cadherin superfamily.during morphogenesis, cell-cell association patterns are dynamically altered. we are interested in how cell adhesion molecules can regulate the patterning of cellular assemblies. cadherins, a group of cell-cell adhesion receptors, are crucial for the organized assembly of many cell types, but they also regulate dynamic aspects of cell association. for example, during neural crest emigration from the neural tube, the cadherin subtypes expressed by crest cells are switched from one subtype to anot ...200011128982
palliative treatment of inoperable malignant esophageal strictures with conically shaped covered self-expanding stents.to investigate the effectiveness of conically shaped covered self-expanding (flamingo) stents in palliative treatment of malignant esophagogastric strictures in terms of patency, improved dysphagia score and survival.200111259944
convergence and divergence in the evolution of aquatic birds.aquatic birds exceed other terrestrial vertebrates in the diversity of their adaptations to aquatic niches. for many species this has created difficulty in understanding their evolutionary origin and, in particular, for the flamingos, hamerkop, shoebill and pelecaniforms. here, new evidence from nuclear and mitochondrial dna sequences and dna-dna hybridization data indicates extensive morphological convergence and divergence in aquatic birds. among the unexpected findings is a grouping of flamin ...200111429133
metal levels in feathers of cormorants, flamingos and gulls from the coast of namibia in southern africa.arsenic, cadmium, chromium, lead, manganese, mercury, selemium, and tin concentrations were measured in the feathers of cape cormorant (phalacrocorax capensis), hartlaub's gull (larus hartlaubii), kelp gull (larus dominicanus), and lesser flamingo (phoeniconaias minor) from the coast of namibia in southern africa. metal concentrations in feathers represent the concentrations in the blood supply at the time of feather formation. cape cormorants are piscivores; kelp gulls are primarily piscivores; ...200111465667
a comparison of 3 types of covered metal stents for the palliation of patients with dysphagia caused by esophagogastric carcinoma: a prospective, randomized study.there are currently 3 types of covered metal stents available in europe for palliation of patients with malignant dysphagia. their relative merits have not been compared in a prospective, randomized study.200111474382
asymmetric colocalization of flamingo, a seven-pass transmembrane cadherin, and dishevelled in planar cell polarization.the drosophila wing provides an appropriate model system for studying genetic programming of planar cell polarity (pcp) [1-4]. each wing cell respects the proximodistal (pd) axis; i.e., it localizes an assembly of actin bundles to its distalmost vertex and produces a single prehair. this pd polarization requires the redistribution of flamingo (fmi), a seven-pass transmembrane cadherin, to proximal/distal cell boundaries; otherwise, the cell mislocalizes the prehair [5]. achievement of the biased ...200111516647
follow-up of participants in the trois-rivières growth and development study: examining their health-related fitness and risk factors as adults.the purpose of the study was to examine the effect of daily physical education in primary school on some indices of fitness (pwc170/kg, handgrip strength, sit and reach flexibility, abdominal muscle endurance, and balance), cardiovascular health (lipid profile, waist-to-hip ratio), and anthropometry in the adult years. four subsamples of participants in the trois-rivières growth and development study were examined: experimental men (n = 32), experimental women (n = 36), control men (n = 30), and ...200011534017
frizzled signaling and cell-cell interactions in planar polarity.the function of the frizzled pathway is essential for the formation of the array of distally pointing hairs found on the drosophila wing. previous research found that regulating the subcellular location for hair initiation controlled hair polarity. recent work argues a graded frizzled-dependent signal results in the accumulation of the frizzled, dishevelled and flamingo proteins along the distal edge of the wing cells. this cortical mark leads to the local activation of downstream gene products ...200111544034
the flamingo-related mouse celsr family (celsr1-3) genes exhibit distinct patterns of expression during embryonic development.we have isolated cdnas for three members of a family of seven-pass transmembrane cadherins in mouse (celsr1, 2 and 3). these three genes represent vertebrate homologues of flamingo/starry night, recently identified as an essential component of the drosophila planar cell polarity pathway and for the correct formation of dendritic fields within the drosophila peripheral nervous system. in this study, we show that each member of the mouse celsr family exhibit distinct patterns of expression within ...200111677057
the ankyrin repeat protein diego mediates frizzled-dependent planar polarization.during planar polarization of the drosophila wing epithelium, the homophilic adhesion molecule flamingo localizes to proximal/distal cell boundaries in response to frizzled signaling; perturbing frizzled signaling alters flamingo distribution, many cell diameters distant, by a mechanism that is not well understood. this work identifies a tissue polarity gene, diego, that comprises six ankyrin repeats and colocalizes with flamingo at proximal/distal boundaries. diego is specifically required for ...200111703927
west nile fever in israel 1999-2000: from geese to humans.west nile virus (wnv) caused disease outbreaks in israel in the 1950s and the late 1970s. in 1998 an outbreak of wnv in goose farms and evidence of infection in dead migratory birds were reported. consequently, human diagnostic services for wnv were resumed, including virus isolation, serology, and rt-pcr. risk factors for infection were assessed by a serological survey in 1999, which revealed a seroprevalence of (a) 86% in people who had close contact with sick geese, (b) 28% in people in areas ...200111797770
developmental expression profiles of celsr (flamingo) genes in the mouse.celsr, also called flamingo (fmi) genes encode proteins of the cadherin superfamily. celsr cadherins are seven-pass transmembrane proteins with nine cadherin repeats in the extracellular domain, and an anonymous intracellular c-terminus. the drosophila fmi gene regulates epithelial planar cell polarity and dendritic field deployment. the three flamingo gene orthologs in man and rodents are named, respectively, celsr1-3 and celsr1-3. celsr1 and 2 are expressed during early development, in the bra ...200211850187
differential expression of the seven-pass transmembrane cadherin genes celsr1-3 and distribution of the celsr2 protein during mouse development.drosophila flamingo (fmi) is an evolutionally conserved seven-pass transmembrane receptor of the cadherin superfamily. fmi plays multiple roles in patterning neuronal processes and epithelial planar cell polarity. to explore the in vivo roles of fmi homologs in mammals, we previously cloned one of the mouse homologs, mouse flamingo1/celsr2. here, we report the results of our study of its embryonic and postnatal expression patterns together with those of two other paralogs, celsr1 and celsr3. cel ...200211891983
introduction of west nile virus in the middle east by migrating white storks.west nile virus (wnv) was isolated in a flock of 1,200 migrating white storks that landed in eilat, a town in southern israel, on august 26, 1998. strong, hot westerly winds had forced the storks to fly under considerable physical stress before reaching the agricultural land surrounding the town. most of the flock were fledglings, <1 year old, which had hatched in europe. thirteen dead or dying storks were collected 2 days after arrival and submitted to the laboratory for examination. four wnv i ...200211971773
asymmetric localization of frizzled and the determination of notch-dependent cell fate in the drosophila eye.during patterning of the drosophila eye, a critical step is the notch-mediated cell fate decision that determines the identities of the r3/r4 photoreceptor pair in each ommatidium. depending on the decision taken, the ommatidium adopts either the dorsal or ventral chiral form. this decision is directed by the activity of the planar polarity genes, and, in particular, higher activity of the receptor frizzled confers r3 fate.200212015117
the atypical cadherin flamingo links frizzled and notch signaling in planar polarity establishment in the drosophila eye.planar cell polarity is established in the drosophila eye through distinct fate specification of photoreceptors r3 and r4 by a two-tiered mechanism employing fz and notch signaling: fz signaling specifies r3 and induces dl to activate notch in r4. we show that the atypical cadherin flamingo (fmi) plays critical, but distinct, roles in both r3 and r4. fmi is first enriched at equatorial cell borders of r3/r4, positively interacting with fz/dsh. subsequently, fmi is upregulated in r4 by notch and ...200212015972
tiling of the drosophila epidermis by multidendritic sensory neurons.insect dendritic arborization (da) neurons provide an opportunity to examine how diverse dendrite morphologies and dendritic territories are established during development. we have examined the morphologies of drosophila da neurons by using the marcm (mosaic analysis with a repressible cell marker) system. we show that each of the 15 neurons per abdominal hemisegment spread dendrites to characteristic regions of the epidermis. we place these neurons into four distinct morphological classes disti ...200212050135
genetic manipulation of single neurons in vivo reveals specific roles of flamingo in neuronal morphogenesis.to study the roles of intracellular factors in neuronal morphogenesis, we used the mosaic analysis with a repressible cell marker (marcm) technique to visualize identifiable single multiple dendritic (md) neurons in living drosophila larvae. we found that individual neurons in the peripheral nervous system (pns) developed clear morphological polarity and diverse dendritic branching patterns in larval stages. each md neuron in the same dorsal cluster developed a unique dendritic field, suggesting ...200212074553
expression of the ankyrin repeat domain 6 gene (ankrd6) during mouse brain development.the structure and developmental expression pattern of the ankyrin repeat domain 6 (ankrd6) gene, initially named diversin, were studied in the mouse. ankrd6 is transcribed as a 5.8-kb mrna composed of 15 exons that encodes a 712 amino acid protein with 6 ankyrin repeats. ankrd6 is expressed prominently in the developing brain from e12 to maturity, suggesting a role during brain development. in embryos, expression is maximal in ventricular zones of neuronal proliferation and intermediate zones of ...200212203740
palliative treatment of inoperable malignant esophageal strictures with metal stents: one center's experience with four different stents.our center's experience with ultraflex, flamingo, sr stent and flexstent for the palliation of malignant esophageal strictures is reported, and current pertinent literature is reviewed.200212204402
catastrophic mortality of flamingos in a spanish national park caused by cyanobacteria. 200212503790
identification and characterization of human prickle1 and prickle2 genes as well as mouse prickle1 and prickle2 genes homologous to drosophila tissue polarity gene prickle.drosophila prickle is implicated in tissue polarity or planar polarity. here, human prickle1 gene corresponding to flj31937 cdna and human prickle2 gene corresponding to dkfzp686d143 cdna were identified to be homologous to drosophila prickle gene by using bioinformatics. prickle1 gene was mapped to human chromosome 12p11-q12, and prickle2 gene was mapped to human chromosome 3p14. mouse prickle1 and prickle2 genes were next identified in mouse genome draft sequences nw_000106.1 and nw_000262.1, ...200312525887
a mosaic genetic screen for genes necessary for drosophila mushroom body neuronal morphogenesis.neurons undergo extensive morphogenesis during development. to systematically identify genes important for different aspects of neuronal morphogenesis, we performed a genetic screen using the marcm system in the mushroom body (mb) neurons of the drosophila brain. mutations on the right arm of chromosome 2 (which contains approximately 20% of the drosophila genome) were made homozygous in a small subset of uniquely labeled mb neurons. independently mutagenized chromosomes (4600) were screened, yi ...200312571111
test-retest reliability of the eurofit test battery administered to university students.the purpose of this study was to examine the test-retest reliability of the eurofit motor fitness tests performed by university students. a total of 98 undergraduate students who were enrolled in physical education departments in greece participated (29 men aged 19.5 +/- 2.7 hr. and 66 women aged 19.4 +/- 2.7 yr.). all eurofit motor fitness tests and anthropometric measurements were obtained twice with one week between the two measurements. intraclass correlation coefficient indicated satisfacto ...200212578274
strabismus requires flamingo and prickle function to regulate tissue polarity in the drosophila eye.tissue polarity in drosophila is regulated by a number of genes that are thought to function in a complex, many of which interact genetically and/or physically, co-localize, and require other tissue polarity proteins for their localization. we report the enhancement of the strabismus tissue polarity phenotype by mutations in two other tissue polarity genes, flamingo and prickle. flamingo is autonomously required for the establishment of ommatidial polarity. its localization is dynamic throughout ...200312642492
flamingo regulates r8 axon-axon and axon-target interactions in the drosophila visual system.photoreceptors (r cells) in the drosophila retina connect to targets in three distinct layers of the optic lobe of the brain: r1-r6 connect to the lamina, and r7 and r8 connect to distinct layers in the medulla. in each of these layers, r axon termini are arranged in evenly spaced topographic arrays. in a genetic screen for mutants with abnormal r cell connectivity, we recovered mutations in flamingo (fmi). fmi encodes a seven-transmembrane cadherin, previously shown to function in planar cell p ...200312747830
the protocadherin flamingo is required for axon target selection in the drosophila visual system.photoreceptor neurons (r cells) in the drosophila visual system elaborate a precise map of visual space in the brain. the eye contains some 750 identical modules called ommatidia, each containing eight photoreceptor cells (r1-r8). cells r1-r6 synapse in the lamina; r7 and r8 extend through the lamina and terminate in the underlying medulla. in a screen for visual behavior mutants, we identified alleles of flamingo (fmi) that disrupt the precise maps elaborated by these neurons. these mutant r1-r ...200312754514
flamingo, a cadherin-type receptor involved in the drosophila planar polarity pathway, can block signaling via the canonical wnt pathway in xenopus laevis.the flamingo gene encodes a seven-pass transmembrane receptor of the cadherin super family and is one of a growing number of components identified as being necessary for the establishment of planar polarity in the drosophila wing. although vertebrate homologues of flamingo have been identified in both man and mice, no function has as yet been ascribed to them. here, we report the cloning of the xenopus homologue of flamingo (xfmi). xfmi is expressed in the dorsal ectoderm during gastrulation and ...200312755329
strabismus is asymmetrically localised and binds to prickle and dishevelled during drosophila planar polarity patterning.planar polarity decisions in the wing of drosophila involve the assembly of asymmetric protein complexes containing the conserved receptor frizzled. in this study, we analyse the role of the van gogh/strabismus gene in the formation of these complexes and cell polarisation. we find that the strabismus protein becomes asymmetrically localised to the proximal edge of cells. in the absence of strabismus activity, the planar polarity proteins dishevelled and prickle are mislocalised in the cell. we ...200312756182
are metal stents effective for palliation of malignant dysphagia and fistulas?one of the available treatments for unresectable oesophagogastric malignancies is the insertion of metal stents.200312801040
a randomised prospective comparison of the flamingo wallstent and ultraflex stent for palliation of dysphagia associated with lower third oesophageal carcinoma.covered metallic oesophageal stents offer effective palliation of malignant oesophageal strictures. however, first generation devices were associated with a high rate of migration, particularly when used in the lower oesophagus.200312801944
susceptibility of flamingos to cyanobacterial toxins via feeding. 200312825708
mutation of celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse.we identified two novel mouse mutants with abnormal head-shaking behavior and neural tube defects during the course of independent enu mutagenesis experiments. the heterozygous and homozygous mutants exhibit defects in the orientation of sensory hair cells in the organ of corti, indicating a defect in planar cell polarity. the homozygous mutants exhibit severe neural tube defects as a result of failure to initiate neural tube closure. we show that these mutants, spin cycle and crash, carry indep ...200312842012
actin filament-stabilizing protein tropomyosin regulates the size of dendritic fields.dendritic arbors of different neuronal subtypes cover distinct spatial territories, known as dendritic fields, to receive specific inputs in a nervous system. how the size of dendritic fields is determined by cell-intrinsic factors during development remains primarily unknown. to address this issue, we used the drosophila embryonic peripheral nervous system. in each hemisegment, six dorsal cluster dendritic arborization (da) neurons elaborate stereotypic dendritic branching patterns underneath t ...200312867499
growth characteristics of the veterinary vaccine candidate chimerivax-west nile (wn) virus in aedes and culex mosquitoes.in 1999 west nile (wn) virus was introduced to north america where this flavivirus has spread rapidly among wildlife (especially birds) transmitted by various species of mosquitoes (diptera: culicidae). increasing numbers of cases and deaths among humans, horses and other domestic animals require development of effective vaccines. 'chimerivax-west nile(vet)' is being developed for use as a veterinary vaccine to protect against wn infection. this chimeric virus contains the pre-membrane (prm) and ...200312941006
[isolation and identification of canthaxanthin in the lesser flamingo (phoenicolnaias minor)]. 196313981133
[what do flamingos feed their young?]. 196414134604
astaxanthin in the american flamingo. 195514383774
egfr signaling regulates ommatidial rotation and cell motility in the drosophila eye via mapk/pnt signaling and the ras effector canoe/af6.epidermal growth factor-receptor (egfr) signaling is evolutionarily conserved and controls a variety of different cellular processes. in drosophila these include proliferation, patterning, cell-fate determination, migration and survival. here we provide evidence for a new role of egfr signaling in controlling ommatidial rotation during planar cell polarity (pcp) establishment in the drosophila eye. although the signaling pathways involved in pcp establishment and photoreceptor cell-type specific ...200314507782
use of large-diameter metallic stents to seal traumatic nonmalignant perforations of the esophagus.surgery for traumatic, non-malignant perforation of the esophagus in patients presenting more than 24 hours after its occurrence carries a high morbidity and mortality. covered metallic stents have been used to effectively seal perforations in individual patients with boerhaave's syndrome.200314528208
absence of humoral response in flamingos and red-tailed hawks to experimental vaccination with a killed west nile virus vaccine.sixteen chilean flamingos, phoenicopterus chiles, and 10 red-tailed hawks, buteo jamacensis, were vaccinated in the pectoral muscle with 0.2 ml of a commercially produced killed west nile virus vaccine intended for use in horses. half the birds of each species received a booster vaccination 3 weeks after the first injection. three weeks after the booster vaccination, none of 13 birds surveyed had detectable antibody to west nile virus.200314562907
breaking cellular symmetry along planar axes in drosophila and vertebrates.in many organs, epithelial cells are polarized not only along the apicobasal axis, but also along a second axis within a plane. acquisition of the latter polarity, known as planar cell polarity (pcp) or tissue polarity, is crucial for specialized cellular functions. genetic programming of pcp has been most thoroughly studied in drosophila, which has allowed identification of a number of regulatory molecules that are evolutionally conserved. one group of the regulators is responsible for interpre ...200314688226
planar polarity from flies to vertebrates.planar cell polarity (pcp) has been demonstrated in the epithelium of organisms from flies to humans. recent research has revealed that the planar organization of cells requires a conserved set of genes, known as the pcp genes. tbe pcp proteins frizzled (fz) and dishevelled (dsh) function as key players in pcp signalling. although fz and dsh are also involved in wingless (wg)/wnt signalling, these proteins have independent functions in a non-canonical pathway dedicated to pcp. reorganization of ...200414730010
exposure to trace elements of flamingos living in a biosphere reserve, the camargue (france).recent research has shown that some adult flamingos phoenicopterus roseus collected from the camargue biosphere reserve had tissue metal concentrations considerably higher than the average for this species. as the range of these birds is large, the origin of the contamination was unknown. blood and feather samples from nestling flamingos were therefore analysed for trace metals to determine the presence and origin of local contamination. a comparison of elemental concentration in the feathers of ...199115092161
west nile virus infection in reindeer (rangifer tarandus).west nile virus (wnv) infection in 4 reindeer (rangifer tarandus) resulted in lymphohistiocytic encephalomyelitis within the medulla oblongata and cervical spinal cord. immunohistochemistry revealed wnv antigen within neurons and among mononuclear cell infiltrates. these represent the first known cases of clinical wnv infection in cervidae. clinical signs and lesions were similar to those described in horses. nucleotide sequence of a 768-bp region of the wnv e-glycoprotein gene revealed 1 nucleo ...200415152836
armadillo/beta-catenin-dependent wnt signalling is required for the polarisation of epidermal cells during dorsal closure in drosophila.at the end of germband retraction, the dorsal epidermis of the drosophila embryo exhibits a discontinuity that is covered by the amnioserosa. the process of dorsal closure (dc) involves a coordinated set of cell-shape changes within the epidermis and the amnioserosa that result in epidermal continuity. polarisation of the dorsal-most epidermal (dme) cells in the plane of the epithelium is an important aspect of dc. the dme cells of embryos mutant for wingless or dishevelled exhibit polarisation ...200415226252
ptk7/cck-4 is a novel regulator of planar cell polarity in vertebrates.in addition to the apical-basal polarity pathway operating in epithelial cells, a planar cell polarity (pcp) pathway establishes polarity within the plane of epithelial tissues and is conserved from drosophila to mammals. in drosophila, a 'core' group of pcp genes including frizzled (fz), flamingo/starry night, dishevelled (dsh), van gogh/strabismus and prickle, function to regulate wing hair, bristle and ommatidial polarity. in vertebrates, the pcp pathway regulates convergent extension movemen ...200415229603
efficacy of training program for ambulatory competence in elderly women.the optimal prevention of osteoporotic fractures in the elderly consists of increasing the bone density and preventing falls. we report on the efficacy of training program to promote ambulatory competence in elderly women. twenty-five elderly women were enrolled in our training program, which is a three-month program consisting of dynamic balance training with galileo 900 (novotec, pforzheim, germany) once a week, combined with daily static balance (standing on one leg like a flamingo) and resis ...200415247512
regulation of dendritic maintenance and growth by a mammalian 7-pass transmembrane cadherin.drosophila flamingo is a 7-pass transmembrane cadherin that is necessary for dendritic patterning and axon guidance. how it works at the molecular level and whether homologs of flamingo play similar roles in mammalian neurons or not have been unanswered questions. here, we performed loss-of-function analysis using an rnai system and organotypic brain slice cultures to address the role of a mammalian flamingo homolog, celsr2. knocking down celsr2 resulted in prominent simplification of dendritic ...200415296717
diego interacts with prickle and strabismus/van gogh to localize planar cell polarity complexes.planar cell polarity (pcp) in the drosophila eye is established by the distinct fate specifications of photoreceptors r3 and r4, and is regulated by the frizzled (fz)/pcp signaling pathway. before the pcp proteins become asymmetrically localized to opposite poles of the cell in response to fz/pcp signaling, they are uniformly apically colocalized. little is known about how the apical localization is maintained. we provide evidence that the pcp protein diego (dgo) promotes the maintenance of apic ...200415306567
cell interactions and planar polarity in the abdominal epidermis of drosophila.the integument of the drosophila adult abdomen bears oriented hairs and bristles that indicate the planar polarity of the epidermal cells. we study four polarity genes, frizzled (fz), prickle (pk), van gogh/strabismus (vang/stbm) and starry night/flamingo (stan/fmi), and note what happens when these genes are either removed or overexpressed in clones of cells. the edges of the clones are interfaces between cells that carry different amounts of gene products, interfaces that can cause reversals o ...200415329345
causes and treatment of recurrent dysphagia after self-expanding metal stent placement for palliation of esophageal carcinoma.recurrent dysphagia frequently complicates the palliative treatment of esophageal cancer with self-expanding metal stents. strategies for repeat interventions and subsequent outcomes have not been adequately reported to date.200415452784
spalt transcription factors are required for r3/r4 specification and establishment of planar cell polarity in the drosophila eye.the establishment of planar cell polarity in the drosophila eye requires correct specification of the r3/r4 pair of photoreceptor cells. in response to a polarizing factor, frizzled signaling specifies r3 and induces delta, which activates notch in the neighboring cell, specifying it as r4. here, we show that the spalt zinc-finger transcription factors (spalt major and spalt-related) are part of the molecular mechanisms regulating r3/r4 specification and planar cell polarity establishment. in mo ...200415509769
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