Publications

trypanocidal activity of chemical constituents from lychnophora salicifolia mart.	the ethyl acetate extract from leaves plus inflorescences of l. salicifolia showed significant trypanocidal activity against trypomastigote forms of t. cruzi, which was due to the flavonoid quercetin-7,3',4'-trimethyl ether and the sesquiterpenoid lychnopholic acid. despite the use of some species of lychnophora in folk medicine for pain relief, crude extracts from l. salicifolia mart. showed no antinociceptive activity in the mouse writhing test.	2004	15162371
effects of chlorogenic acid on neutrophil locomotion functions in response to inflammatory stimulus.	species of lychnophora are used in brazilian folk medicine as analgesic and anti-inflammatory agents. chlorogenic acid (cga) and their analogues are important components of polar extracts of these species, as well in several european and asian medicinal plants. some of these phenolic compounds display anti-inflammatory effects. in this paper we report the isolation of cga from lychnophora salicifolia and its effects on functions involved in neutrophils locomotion.	2011	21414398
a new hplc-dad-ms/ms method for the simultaneous determination of major compounds in the crude extract of lychnophora salicifolia mart. (brazilian arnicão) leaves: application to chemical variability evaluation.	lychnophora salicifolia mart., which occurs in the brazilian cerrado in the states of bahia and minas gerais as well as in the southeast of the state of goiás, is the most widely distributed and also the most polymorphic species of the genus. this plant is popularly known to have anti-inflammatory and analgesic activities. in this work, we have studied the variation in terms of polar metabolites of ninety-three lychnophora salicifolia mart. specimens collected from different regions of the brazi ...	2012	23021804
evaluation of intestinal permeability of vicenin-2 and lychnopholic acid from lychnophora salicifolia (brazilian arnicão) using caco-2 cells.	lychnophora salicifolia, commonly known as "arnicão", is used as an anti-inflammatory agent and as a flavoring agent in the brazilian traditional spirit "cachaça". in this work, the permeation process of vicenin-2 (1) and lychnopholic acid (2) (major secondary metabolites from the hydroalcoholic extract) was investigated using caco-2 cells. for this investigation, a new hplc-dad method was developed and validated for the quantification step. it was observed that 2 crosses the caco-2 cell monolay ...	2014	24279746
mass spectrometry of flavonoid vicenin-2, based sunlight barriers in lychnophora species.	lychnophora salicifolia plants collected from four different places in brazil (three states: goias, minas gerais and bahia) revealed a conserved accumulation of vicenin-2, a di-c-glycosyl flavonoid. quantitative studies by uplc-ms/ms showed high concentration of vicenin-2 in leaves from sixty specimens of six lychnophora species. so the tissue distributions of vicenin-2 were evaluated in wild lychnophora leaves (asteraceae) by laser based imaging mass spectrometry (ims) to propose its distributi ...	2014	24603617