Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| pathogenic factors in cirrhosis with and without hepatocellular carcinoma: a multicenter italian study. | we designed a multicenter cross-sectional study to evaluate the role of alcohol abuse, the hepatitis viruses and other pathogenic factors in cirrhosis and hepatocellular carcinoma. a total of 1,829 consecutive cirrhosis patients, with or without hcc, was enrolled over 6 mo in 21 centers throughout italy. the etiological categories and diagnostic criteria were preestablished. the median age of the patients was 59 yr (range, 13 to 85 yr); 63.6% of the patients were graded as child class a, 23.4% a ... | 1994 | 7523273 |
| primary hepatocellular carcinoma and viral hepatitis b and c infection in bangladeshi subjects. | potential risk factors for the development of primary hepatocellular carcinoma and the prevalence and role of infection with viral hepatitis b and hepatitis c were investigated in 54 adult patients of bangladeshi origin (45 male, age range 20-75 years), comprising 46 patients resident in bangladesh (group 1) and 8 patients who had emigrated to the uk 10-20 years previously (group 2). of the 46 patients in group 1 (37 male), 16 had hepatocellular carcinoma, 10 had uncomplicated cirrhosis, and 20 ... | 1995 | 7861482 |
| detection of anti-hepatitis c virus antibodies in patients undergoing dialysis by utilizing a hepatitis c virus 3.0 assay: correlation with hepatitis c virus rna. | hepatitis c virus (hcv) infection is endemic in long-term dialysis units. we assessed the performance of a recently developed hcv 3.0 assay for the detection of hcv antibodies in patients undergoing dialysis. the study evaluated 128 patients undergoing long-term maintenance hemodialysis. anti-hcv was detected by 2.0 and 3.0 enzyme immunoassay (eia). results were confirmed with recombinant immunoblot assays (riba 2.0 and riba 3.0). hcv rna was detected by using reverse transcriptase-polymerase ch ... | 1998 | 9665375 |
| long-term outcome of chronic hepatitis c virus infection in primary hypogammaglobulinaemia. | the clinical course of hcv infection in patients with primary hypogammaglobulinaemia appears to be more severe than in immunocompetent patients. we studied the long-term course of chronic hcv infection in 20 norwegian hypogammaglobulinaemia patients with a 13-15 year known history of hcv infection. twelve of 20 patients developed cirrhosis during the observation period (1984-1999), and the remaining eight also had chronic liver disease verified by liver biopsy in the majority of the cases. eleve ... | 1999 | 10627859 |
| hepatocyte steatosis is a cytopathic effect of hepatitis c virus genotype 3. | patients infected with the hepatitis c virus (hcv) often have liver steatosis, suggesting the possibility of a viral cytopathic effect. the aim of this study was to correlate the occurrence and severity of liver steatosis with hcv rna type, level and sequence of the core-encoding region. | 2000 | 10905593 |
| new infection with heterotypic hepatitis c virus in a patient with long-term hepatitis c virus eradication. | experimental hepatitis c virus infection in chimpanzees has shown that natural hepatitis c virus infection does not induce protective immunity and reinfection can occur in seroconverted animals. | 2001 | 11816550 |
| guidelines for preventing opportunistic infections among hiv-infected persons--2002. recommendations of the u.s. public health service and the infectious diseases society of america. | in 1995, the u.s. public health service (usphs) and the infectious diseases society of america (idsa) developed guidelines for preventing opportunistic infections (ois) among persons infected with human immunodeficiency virus (hiv); these guidelines were updated in 1997 and 1999. this fourth edition of the guidelines, made available on the internet in 2001, is intended for clinicians and other health-care providers who care for hiv-infected persons. the goal of these guidelines is to provide evi ... | 2002 | 12081007 |
| hepatitis c virus genotype 3 is cytopathic to hepatocytes: reversal of hepatic steatosis after sustained therapeutic response. | on the basis of cross-sectional studies, it has been proposed that hepatic steatosis is a cytopathic effect of hepatitis c virus (hcv) genotype 3 but not genotype 1 infections. we tested this hypothesis by examining whether antiviral treatment altered hepatic steatosis in chronic hepatitis c. in 28 patients with genotype 1 and 34 with genotype 3 hcv, we determined the severity of steatosis in pre- and posttreatment liver biopsies using computer-assisted morphometric image analysis as well as con ... | 2002 | 12395339 |
| steatosis accelerates fibrosis development over time in hepatitis c virus genotype 3 infected patients. | steatosis is common in patients with hepatitis c virus (hcv) infection. its influence on disease progression is only partially understood. the aim of this study was to evaluate the impact of steatosis on fibrosis progression over time in relation to hcv genotype. | 2002 | 12445426 |
| guidelines for preventing opportunistic infections among hiv-infected persons--2002. recommendations of the u.s. public health service and the infectious diseases society of america. | in 1995, the u.s. public health service (usphs) and the infectious diseases society of america (idsa) developed guidelines for preventing opportunistic infections (ois) among persons infected with human immunodeficiency virus (hiv); these guidelines were updated in 1997 and 1999. this fourth edition of the guidelines, made available on the internet in 2001, is intended for clinicians and other health-care providers who care for hiv-infected persons. the goal of these guidelines is to provide evi ... | 2002 | 12617574 |
| comparative analysis of viral titers and histologic features of pakistani patients infected with hepatitis c virus type 3. | serum hepatitis c virus (hcv) rna levels and genotypes are considered to be important determinants of the response to interferon treatment. generally, patterns of viral loads have been reported for hcv type 1 infections and categorized as low- or high-level viremia. we studied the distribution of hcv rna levels in patients predominantly infected with hcv type 3 and correlated it with hepatic damage. | 2002 | 12718820 |
| characterisation of the differences between hepatitis c virus genotype 3 and 1 glycoproteins. | sequence variation in the envelope e1 and e2 glycoproteins of hepatitis c virus (hcv) could account for differences in disease pathogenesis in patients infected with different genotypes. a cdna encoding the structural region of the hepatitis c polyprotein was constructed to match the majority sequence of viral rna extracted from a patient infected with genotype 3a (designated strain hcv3a-gla). the principal differences predicted between e2 of hcv3a-gla and the corresponding h77c genotype 1a pro ... | 2003 | 12766998 |
| the mechanisms underlying hepatitis c virus genotype 3-mediated liver damage. | 2003 | 12873832 | |
| liver fibrosis is not associated with steatosis but with necroinflammation in french patients with chronic hepatitis c. | in chronic hepatitis c, it has been suggested that steatosis could accelerate progression of fibrosis. however, results of the few published studies are controversial. aim: to determine the characteristics (epidemiological, biological, and histological) associated with steatosis and its relationship with liver lesions (grade of necroinflammation and stage of fibrosis) in patients with chronic hepatitis c. | 2003 | 14570735 |
| effect of antiviral treatment on evolution of liver steatosis in patients with chronic hepatitis c: indirect evidence of a role of hepatitis c virus genotype 3 in steatosis. | recent studies suggest that liver steatosis in chronic hepatitis c may be the expression of a direct cytopathic effect of hepatitis c virus (hcv), particularly in patients infected with genotype 3. to investigate this hypothesis, we studied the relationship between steatosis evolution and hcv clearance after antiviral treatment in patients with chronic hepatitis c and paired liver biopsies. | 2004 | 14960527 |
| hepatic steatosis in hepatitis c virus genotype 3 infection: does it correlate with body mass index, fibrosis, and hcv risk factors? | hepatic steatosis is a recognized feature of hepatitis c viral infection, particularly in genotype 3. the demographics and the associations contributing to moderate to severe steatosis in genotype 3 are not very well studied. the aim of this study is to determine the demographics and association of steatosis with fibrosis, obesity, diabetes, lipid levels, and risk factors among patients with hepatitis c virus (hcv) genotype 3. two hundred ninety-three consecutive hcv patients (genotype 1, n = 21 ... | 2004 | 14992430 |
| steatosis and liver cell apoptosis in chronic hepatitis c: a mechanism for increased liver injury. | steatosis is increasingly recognized as a cofactor influencing the progression of fibrosis in chronic hepatitis c; however, the mechanisms by which it contributes to liver injury remain uncertain. we studied 125 patients with chronic hepatitis c to assess the effect of steatosis on liver cell apoptosis and the expression of bcl-2, bcl-x(l), bax, and tumor necrosis factor alpha (tnf-alpha) and the relationship between liver cell apoptosis and disease severity. a significant increase in liver cell ... | 2004 | 15122751 |
| high rate of spontaneous clearance of acute hepatitis c virus genotype 3 infection. | treating acute hepatitis c with interferon alpha prevents chronicity in nearly all cases when therapy is initiated within 3 months after infection. however, 15-50% of untreated patients may clear the hepatitis c virus (hcv) spontaneously. therefore, factors are needed to identify patients prior to therapy who have a higher or lower risk for developing a chronic course to avoid unnecessary treatment. the role of the hcv genotype for spontaneous recovery from acute hepatitis c has been discussed c ... | 2004 | 15170633 |
| hepatic steatosis in chronic hepatitis c: impact on response to anti-viral treatment with peg-interferon and ribavirin. | there is increasing evidence that hepatic steatosis contributes to the progression of liver fibrosis, whereas its impact on the efficacy of anti-viral treatment is still under investigation. | 2005 | 16268968 |
| peroxisome proliferator-activated receptor-alpha and -gamma mrna levels are reduced in chronic hepatitis c with steatosis and genotype 3 infection. | steatosis in chronic hepatitis c is associated with inflammation and accelerated fibrogenesis. | 2006 | 16393287 |
| hepatitis c virus genotype 3 predominates in north and central india and is associated with significant histopathologic liver disease. | hepatitis c virus (hcv) genotypes help to tailor the treatment response, but their influence on the disease severity and association with hepatic steatosis is not well understood. the prevalence of hcv genotypes and their correlation with the histopathological severity of liver disease and steatosis in indian patients were studied. hcv-rna and genotyping was carried out in 398 patients with chronic hepatitis c. liver biopsy was available in 292 (73.4%) patients. the severity of liver disease was ... | 2006 | 16482560 |
| hepatic steatosis is associated with fibrosis, nucleoside analogue use, and hepatitis c virus genotype 3 infection in hiv-seropositive patients. | we conducted a study to determine the prevalence and factors associated with hepatic steatosis in human immunodeficiency virus (hiv)-seropositive patients with hepatitis c and to investigate whether steatosis is associated with liver fibrosis. | 2006 | 16804853 |
| direct and indirect evidence for the reversibility of cirrhosis. | the aim of this study was to assess the reversibility of cirrhosis after therapy in a large series of patients with cirrhosis from various etiologies. we performed a retrospective study of 113 patients with biopsy-proven cirrhosis who underwent specific therapy and follow-up biopsies. two pathologists performed blinded analyses of indirect biochemical and morphological signs of cirrhosis. fourteen (12.4%) of the 113 cirrhotic patients had biopsy-proven disappearance of cirrhosis, defined as a de ... | 2006 | 16997354 |
| changing serological status and low vaccination-induced protection rates against hepatitis b characterize chronic hepatitis c virus-infected injecting drug users in greece: need for immunization policy. | to evaluate the serological status of hepatitis b virus infection among greek injecting drug users with chronic hepatitis c virus infection; to correlate hepatitis b virus infection status with the possible time of infection and the principal genotype of hepatitis c virus infection. | 2006 | 17033445 |
| utility of week-4 viral response to tailor treatment duration in hepatitis c virus genotype 3/hiv co-infected patients. | to investigate the utility of a week-4 virological response for sustained response prediction in hepatitis c virus (hcv) genotype 3/hiv-co-infected patients treated with interferon and ribavirin for 24 weeks. | 2007 | 17301566 |
| an evidence of high prevalence of hepatitis c virus in faisalabad, pakistan. | to see the prevalence of hepatitis c virus (hcv) and its genotypes in general population of the locality and to evaluate the importance of reverse transcriptase-polymerase chain reaction (rt-pcr) test over hcv antibody test in early diagnosis of hcv infection. | 2007 | 17334466 |
| [steatosis and non-alcoholic steatohepatitis in patients with chronic hepatitis due to hepatitis c virus infection]. | [corrected] hepatic steatosis is a common finding in patients with hepatitis c, mainly virus c genotype 3. steatosis in these cases might be associated with antiviral treatment response and with prognosis of chronic hepatitis. | 2006 | 17406752 |
| seven nucleotide changes characteristic of the hepatitis c virus genotype 3 5' untranslated region: correlation with reduced in vitro replication. | computer analysis of 158 hepatitis c virus (hcv) 5' untranslated region (5' utr) sequences from the six genotypes showed that the 5' utr from genotype 3 displays seven specific non-contiguous nucleotide changes, at positions 8, 13, 14, 70, 97, 203 and 224. the purpose of this study was to investigate the impact of these changes on translation and replication activities. indeed, these modifications could alter both the internal ribosome entry site (ires) present in the 5' utr of the plus-strand r ... | 2008 | 18089745 |
| low occurrence of occult hepatitis b virus infection and high frequency of hepatitis c virus genotype 3 in hepatocellular carcinoma in brazil. | occult hepatitis b virus (hbv) infection has been reported among patients with hepatitis c virus (hcv) infection and hepatocellular carcinoma (hcc). our aim was to evaluate the presence of occult hbv infection in patients with hcv-related liver cirrhosis (lc) with or without hcc in são paulo, brazil. serum and liver tissue samples from 50 hepatitis b surface antigen-negative patients with hcv-related lc who underwent liver transplantation at the university of são paulo school of medicine hospita ... | 2008 | 18097499 |
| specific polymorphisms in hepatitis c virus genotype 3 core protein associated with intracellular lipid accumulation. | steatosis is a common histological finding and a poor prognostic indicator in patients with hepatitis c virus (hcv) infection. in hcv genotype 3-infected patients, the etiology of steatosis appears to be closely correlated with unknown viral factors that increase intracellular lipid levels. we hypothesize that specific sequence polymorphisms in hcv genotype 3 core protein may be associated with hepatic intracellular lipid accumulation. | 2008 | 18177246 |
| recombinant adenoviruses expressing steatosis-associated hepatitis c virus genotype 3 core protein produce intracellular lipid accumulation in cultured and primary hepatocytes. | steatosis, or "fatty liver", is a common finding in hepatitis c virus (hcv) infection and reflects dysregulation of lipid homeostasis. hcv core protein causes lipid accumulation when expressed in cultured cell lines, which data now indicates is a critical step for hcv replication, assembly and release. previous studies on hcv core and lipid accumulation have been limited by poor efficiency of conventional transfection techniques or the cell line limitations of the available cell culture system. ... | 2009 | 19010361 |
| the optimal ribavirin dose for patients infected with hepatitis c virus genotype 3: should we utilize more? | 2009 | 19177585 | |
| non-invasive assessment of hepatic fat accumulation in chronic hepatitis c by 1h magnetic resonance spectroscopy. | liver biopsy is the standard method for diagnosis of hepatic steatosis, but is invasive and carries some risk of morbidity. | 2010 | 19406596 |
| infection with hepatitis c virus genotype 3--experience of a tertiary health care centre in south india. | to analyse the response rate and the predictive values of virological, biochemical and histological factors on hcv antiviral therapy in hcv genotype 3 infected patients, we retrospectively studied 21 hcv genotype 3 infected patients, who underwent hcv antiviral therapy. low (57%) sustained viral response (svr) rate and significant association of svr with normalization of alanine transaminase (alt) levels were observed in our study. absence of early viral response (evr) showed high (80%) predicti ... | 2010 | 20404464 |
| structural studies of helicase ns3 variants from hepatitis c virus genotype 3 in virological sustained responder and non-responder patients. | abstract: | 2010 | 20630078 |
| hepatitis c virus genotype 3 and the risk of severe liver disease in a large population of drug users in france. | although risk factors for cirrhosis in chronic hepatitis c virus (hcv) infection have been identified, the role of hcv-genotype 3 remains controversial, and limited data are available in drug users. the aim of the study was to assess risk factors for severe liver disease (cirrhosis/hepatocellular carcinoma) in hcv-infected drug users between 2001 and 2007 in france. patients who reported drug use and who had been referred for hcv infection to hepatology centers from a national surveillance syste ... | 2010 | 20827760 |
| sustained virological response with 29 days of debio 025 monotherapy in hepatitis c virus genotype 3. | 2010 | 20966029 | |
| identification of immunogenic regions within the alternative reading frame protein of hepatitis c virus (genotype 3). | hepatitis c virus (hcv) encodes ten classic proteins as well as a newly discovered alternative reading frame protein (arfp) whose synthesis originates from the core region by a +1 frameshift. arfp is produced by all hcv genotypes, but its function remains unknown. although the immunogenicity of genotype 1- and 2-derived arfp in infected hosts has been reported, no information is available for genotype 3-encoded arfp. hcv genotype 3 core/arfp region was pcr amplified, cloned, and sequenced. recom ... | 2011 | 21318731 |
| il28b genetic variation and treatment response in patients with hepatitis c virus genotype 3 infection. | polymorphisms near the il28b gene, which code for interferon (ifn)-?3, predict response to pegylated interferon-a (peg-ifn) and ribavirin treatment in hepatitis c virus (hcv) genotype 1 infected patients. follow-up studies of the effect of il28b gene in hcv non-genotype 1 infected patients have almost always used predominantly hcv genotype 2-infected or mixed genotype 2/3-infected cohorts with results partly conflicting with hcv genotype 1. we performed a retrospective analysis of 281 patients i ... | 2011 | 21374656 |
| use of biological markers in the differential diagnosis of sepsis after liver transplant. | the use of biological markers is developing in the field of liver transplant. biomarkers are being studied in different contexts: 1) detection of tolerant patient; 2) recurrence of hepatitis c virus; 3) diagnosis and prognosis of liver cancers, and 4) diagnosis of infection. the immunological changes occurring in the transplant patient given their previous cirrhotic condition, the immunosuppression received, and possible intercurrent diagnoses (rejection, recurrence of hepatitis c virus…) highli ... | 2011 | 21530952 |
| general evaluation of hepatectomy and hepatocellular carcinoma cases. | although the clinical and histopathological findings of hepatocellular carcinoma are well described, there are few national studies. in this study, we aimed to investigate the relationship between these findings in total or partial hepatectomy specimens in our series. | 2011 | 21935872 |
| role of hepatitis c virus genotype 3 in liver fibrosis progression--a systematic review and meta-analysis. | the progression of liver fibrosis in chronic hepatitis c has long been considered to be independent from viral genotypes. however, recent studies suggest an association between hepatitis c virus (hcv) genotype 3 and accelerated liver disease progression. we completed a systematic review and meta-analysis of studies evaluating the association between hcv genotypes and fibrosis progression. pubmed, embase and isi web of knowledge databases were searched for cohort, cross-sectional and case-control ... | 2011 | 21992794 |