Publications

molecular characterization of three novel murine noroviruses.	murine noroviruses (mnv) comprise a group of newly recognized pathogens infecting laboratory mice. the first reported murine norovirus, murine norovirus 1 (mnv-1), produces a transient infection with a short duration of fecal shedding after infection of immunocompetent laboratory mice. our laboratory subsequently isolated three novel murine noroviruses, murine norovirus 2 (mnv-2), murine norovirus 3 (mnv-3), and murine norovirus 4 (mnv-4), that have markedly different pathogenicity from mnv-1 by ...	2007	17171545
soiled-bedding sentinel detection of murine norovirus 4.	according to serologic surveys, murine norovirus (mnv) is the most prevalent viral pathogen infecting mice used in biomedical research. however, the use of sentinel mice to detect mnv-infected mouse populations has not been evaluated thoroughly. to this end, an experimental method of soiled bedding transfer was created to mimic a quarterly sentinel monitoring program. soiled bedding (15 or 30 cm3) from icr mice experimentally infected with mnv4 was transferred weekly to cages of pair-housed 4-wk ...	2008	18459710
infection with murine norovirus 4 does not alter helicobacter-induced inflammatory bowel disease in il10(-/-) mice.	infection of laboratory mice with murine noroviruses (mnv) is widely prevalent. mnv alters various mouse models of disease, including the helicobacter bilis-induced mouse model of inflammatory bowel disease (ibd) in mdr1a(--) mice. to further characterize the effect of mnv on ibd, we used mice deficient in the immunoregulatory cytokine il10 (il10(-/-) mice). in vitro infection of il10(-/-) bone marrow-derived macrophages (bmdm) with mnv4 cocultured with h. bilis antigens increased the gene expre ...	2014	25296012