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post-coital antifertility activity of annona squamosa and ipomoea fistulosa. 1979432307
phytochemical, pharmacological, antibacterial and anti-ovulatory studies on annona squamosa. 19751178793
[studies on the chemical constituents of annona squamosa].twelve compounds were isolated from annona squamosa. their structures were identified as liriodenine (as-1), moupinamide (as-2), -(-)-kauran-16 alpha-ol-19-oic acid (as-3), 16 beta, 17-dihydroxy-(-)-kauran-19-oic acid (as-4), anonaine (as-5), 16 alpha, 17-dihydroxy-(-)-kauran-19-oic acid (as-6), (-)-isokaur-15(16)-en-17,19-dioic acid (as-7), squamosamide (as-8), 16 alpha-methoxy-(-)-kauran-19-oic acid (as-9), sachanoic acid (as-10), (-)-kauran-19-al-17-oic acid (as-11), daucosterol (as-12). amon ...19921414383
bullatacin, bullatacinone, and squamone, a new bioactive acetogenin, from the bark of annona squamosa.activity-directed fractionation of the stem bark of annona squamosa, monitoring with brine shrimp lethality, led to the isolation of the highly bioactive acetogenins bullatacin [1] and bullatacinone [2], thus demonstrating a new abundant plant source for these potent compounds. a new keto-monotetrahydrofuran acetogenin with a ketolactone terminus, as first seen in bullatacinone [2], was also isolated, characterized by spectral analyses, and named squamone [3]. the cytotoxicities of 3 were increa ...19902348205
squamocin, a new cytotoxic bis-tetrahydrofuran containing acetogenin from annona squamosa. 19883246042
an actidione resistant candida tropicalis from custard apple juice.an actidione resistant yeast, candida tropicalis, was isolated from fermenting custard apple juice. though a slight inhibition of growth was observed on the first day with 5000 ppm of actidione, growth was equal to control after one week. sorbic acid at 500 ppm and above inhibited the growth of this yeast while sodium benzoate and potassium metabisulphite were unable to suppress the growth even at 1000 ppm. fermentation and assimilation of different carbon sources were delayed in the presence of ...19817259152
larvicidal potential of five philippine plants against aedes aegypti (linnaeus) and culex quinquefasciatus (say).five species of philippine plants, reported in the literature to have insecticidal properties, were selected for investigation, namely: anona squamosa ("atis" or sugar apple), eucalyptus globulus ("bagras" or olive gum eucalyptus), lansium domesticum ("lansones"), azadirachta indica ("neem") and codiaeum variegatum ("san francisco" or croton). these were screened and assayed for their larvicidal potential against aedes aedes aegypti (linnaeus) and culex quinquefasciatus (say) by exposing 3rd-4th ...19947667727
[studies on total synthesis of squamosamide].a new natural compound squamosamide isolated from annona squamosa, was synthesized. this compound was characterized by 1h, 13cnmr and ms.19938249600
larvicidal and chemosterilant activity of annona squamosa alkaloids against anopheles stephensi.alkaloids isolated from annona squamosa have shown larvicidal growth-regulating and chemosterilant activities against anopheles stephensi at concentrations of 50 to 200 ppm. adults exposed as larvae to different treatments showed reduced fecundity and fertility in females. mortality in the larvae, pupae and adults produced about a 52-92% decrease in the laboratory experiment. the total developmental period was slightly reduced from the control. treatment with the alkaloids had a significant effe ...19938468579
identification of ent-16 beta, 17-dihydroxykauran-19-oic acid as an anti-hiv principle and isolation of the new diterpenoids annosquamosins a and b from annona squamosa.phytochemical analysis of the fruits of annona squamosa yielded 12 known kaurane derivatives (1-11, 13) and two new kaurane diterpenoids, which have been named annosquamosin a (16 beta-hydroxy-17-acetoxy-ent-kauran-19-al) (12) and annosquamosin b (19-nor-ent-kaurane-4 alpha,16 beta,-17-triol) (14). the structures of the new compounds were established by spectral analyses and chemical evidence. among these 14 compounds, 16 beta, 17-dihydroxy-ent-kauran-19-oic acid (2) showed significant activity ...19968786370
squamotacin: an annonaceous acetogenin with cytotoxic selectivity for the human prostate tumor cell line (pc-3).the bark extracts of annona squamosa yielded a new bioactive acetogenin, squamotacin (1), and the known compound, molvizarin (2), which is new to this species. compound 1 is identical to the potent acetogenin, bullatacin (3), except that the adjacent bistetrahydrofuran (thf) rings and their flanking hydroxyls are shifted two carbons toward the gamma-lactone ring. compound 1 showed cytotoxic selectively for the human prostate tumor cell line (pc-3), with a potency of over 100 million times that o ...19968991957
ige-mediated hypersensitivity to custard-apple. 19979201378
novel mono-tetrahydrofuran ring acetogenins, from the bark of annona squamosa, showing cytotoxic selectivities for the human pancreatic carcinoma cell line, paca-2.the bark of annona squamosa yielded three new mono-tetrahydrofuran (thf) ring acetogenins, each bearing two flanking hydroxyls and a carbonyl group at the c-9 position. these compounds were isolated using the brine shrimp lethality assay as a guide for the bioactivity-directed fractionation. (2,4-cis and trans)-mosinone a (1) is a mixture of ketolactone compounds bearing a threo/trans/threo ring relationship and s double bond two methylene units away from the flanking hydroxyl. the other two new ...19979214729
modifications of allergenicity linked to food technologies.the prevalence of food allergies (fa) has increased over the past fifteen years. the reasons suggested are changes in dietary behaviour and the evolution of food technologies. new cases of fa have been described with chayote, rambutan, arguta, pumpkin seeds, custard apple, and with mycoproteins from fusarium.... additives using food proteins are at high risk: caseinates, lysozyme, cochineal red, papaïn, alpha-amylase, lactase etc. heating can reduce allergenicity or create neo-allergens, as well ...19989503097
mono-thf ring annonaceous acetogenins from annona squamosa.continuing work on the bark of annona squamosa rich. (annonaceae), directed by the brine shrimp lethality test (bst), has resulted in the isolation of three new annonaceous acetogenins, 4-deoxyannoreticuin, cis-4-deoxyannoreticuin, and (2,4-cis and trans)-squamoxinone. the first two are additional examples of acetogenins isolated from this plant species which contain the unusual feature of an oxygen functionality at the c-9 position. they have a hydroxylated mono-thf ring with respective threo/t ...19989542173
three new bioactive bis-adjacent thf-ring acetogenins from the bark of annona squamosa.continuing work on the bioactivity-directed fractionation of the bark of annona squamosa has resulted in the discovery of three new annonaceous acetogenins, (2,4-cis and trans)-squamolinone (1), (2,4-cis and trans)-9-oxoasimicinone (2), and bullacin b (3). compounds 1-3 are all adjacent bis-thf ring acetogenins with 2 representing the first bis-ring acetogenin to contain a carbonyl along its aliphatic chain. compound 3 was selectively cytotoxic in a panel of six human tumor cell lines with a pot ...19989629470
antiplasmodial activity of selected sudanese medicinal plants with emphasis on maytenus senegalensis (lam.) exell.the antiplasmodial activity of plant extracts related to four families was tested on chloroquine sensitive strain 3d7 and chloroquine resistant strain dd2 of plasmodium falciparum. the methanolic extract of harrisonia abyssinica (simaroubaceae) inhibited dd2 with ic50 value of 4.7 microg/ml, while in 3d7, the ic50 value was 10 microg/ml. most of the plants from the family meliaceae showed highly potent antiplasmodial activity against the two tested strains. khaya senegalensis, azadirachta indica ...199910363837
possible relation of atypical parkinsonism in the french west indies with consumption of tropical plants: a case-control study. caribbean parkinsonism study group.in europe and north america, parkinson's disease is the major form of parkinsonism; less than 4% of cases are progressive supranuclear palsy (psp) and about 20% are atypical parkinsonism. the distribution of these subgroups is different in the french west indies. we aimed to define the clinical and demographic specificity of these disorders in guadeloupe and to investigate a postulated link with consumption of herbal tea and fruits from the annonaceae family (annona muricata and annona squamosa) ...199910440304
use of soursop and sweetsop juice in the management of diarrhoea in children. 199810453123
samoquasine a, a benzoquinazoline alkaloid from the seeds of annona squamosa.a benzooxyquinazoline alkaloid, samoquasine a (1), has been isolated from the seeds of annona squamosa, and its structure was elucidated by spectroscopic and chemical methods.200011141125
molluscicidal properties of some species of annona.in search for plant molluscicides for the vector control of schistosomiasis, ethanolic extracts from different parts of six species of the annonaceae family were evaluated against adult forms and egg masses of biomphalaria glabrata. results from accurate experiments indicate that the majority of analyzed extracts possess properties lethal to biomphalaria glabrata, some of them with significant ld90 values (< 20 ppm), as showed for annona crassiflora m: [pulp and seed (ld50 = 13.21), steem (2.34) ...200111315753
anti-headlice activity of a preparation of annona squamosa seed extract.various parts of annona squamosa linn. (custard apple) have long been used in thai folk medicine. the effectiveness of organic solvent extracts of custard apple seeds and leaves against headlice has been reported. the present study is focused on the efficacy and stability of seed extract prepared as a cream. a petroleum ether extract of seeds was prepared as a 20% w/w oil in water cream and tested for anti-headlice activity in school girls. after a 3 hour-hair exposure to 20 g of freshly prepare ...200011414452
antimicrobial and pesticidal activity of partially purified flavonoids of annona squamosa.foliar extracts of annona squamosa (family: annonaceae) were screened for antimicrobial and insecticidal activity against the common microbial infestants of pulses and the stored grain pest pulse beetle, callosobruchus chinensis (coleoptera: bruchidae). flavonoids isolated from aqueous extracts of a squamosa showed antimicrobial activity against all the common microbial contaminants of pulses and 80% insecticidal activity against c chinensis at a concentration of 0.07 mg ml-1. various physico-ch ...200211838282
callus cultures of annona squamosa for the production of annonaceous acetogenins.callus cultures of annona squamosa were induced using different explants including petals, seed contents (megagametophyte and embryo) and fruits (mesocarp). growth of the calli induced from the explants was found to be influenced by the type, concentration and ratio of auxin vs. cytokinin. the content of squamocin (67.8 microg g(-1) dry weight) in calli cultured on gamborg b-5 medium containing 5.0 mg l(-1) naphthalene acetic acid and 4.0 mg l(-1) zeatin was nearly seven times higher than that i ...200212118503
new ent-kaurane diterpenoids with anti-platelet aggregation activity from annona squamosa.a phytochemical investigation on the stems of annona squamosa led to the isolation of six new ent-kaurane diterpenoids, annomosin a (16beta-hydroxy-19-al-ent-kauran-17-yl 16beta-hydro-19-al-ent-kauran-17-oate) (1), annosquamosin c (16alpha-hydro-17-hydroxy-19-nor-ent-kauran-4alpha-ol) (2), annosquamosin d (16beta-acetoxy-17-hydroxy-19-nor-ent-kauran-4alpha-ol) (3), annosquamosin e (16beta-hydroxy-17-acetoxy-19-nor-ent-kauran-4alpha-formate) (4), annosquamosin f (16beta-hydroxy-17-acetoxy-18-nor- ...200212398544
squamocin-o(1) and squamocin-o(2), new adjacent bis-tetrahydrofuran acetogenins from the seeds of annona squamosa.two bis-tetrahydrofuran acetogenins, squamocin-o(1) (1) and squamocin-o(2) (2), were isolated from a meoh extract of seeds of annona squamosa l. their structures were determined by spectral means including precursor-ion scanning mass spectral analysis for their aminal derivatives. the configurations at the oxymethine chiral centers were assigned as 12r,15r,16r,19r,20r,23r,24s,28s,36s for 1 and 12s,15r,16r,19r,20r,23r,24s, 28s,36s for 2, based on 1h nmr analysis of their mosher's ester derivative ...200212453534
effects of annona squamosa extract on early pregnancy in rats.annona squamosa linn., family annonaceae, is said to show varied medicinal effects, including insecticide, antiovulatory and abortifacient. the purpose of present study was to investigate if a. squamosa seed aqueous extract, in doses higher than that popularly used to provoke abortion, interferes with reproductive performance, and to correlate the ingestion of this extract with possible alterations in rat embryonic implantation. doses of 300 mg/kg (treated group i, n = 17) and 600 mg/kg (treated ...200212487333
evaluation of mosquitocidal activity of annona squamosa leaves against filarial vector mosquito, culex quinquefasciatus say.methanolic extract of leaves of a. squamosa was tested for mosquitocidal effect against c. quinquefasciatus. a liquid mosquito insecticide formulation was prepared with the extract (1, 3 and 5 %w/w) using deodorized kerosene as solvent and investigated for its knock-down and 24 hr mortality. the extract formulation produced dose dependent activity, exhibited significantly shorter knock down kd50 and kd90 values and produced significant mortality. the results suggest the potential mosquitocidal e ...200212635713
oral allergic syndrome after ingestion of custard apple. 200312653803
unproductivity in the colchicine-induced tetraploids of annona squamosa l. 196014405938
antidiabetic activity of aqueous leaf extract of annona squamosa in streptozotocin-nicotinamide type 2 diabetic rats.the claim by some tribal populations in parts of northern india that the young leaves of the custard apple tree, annona squamosa l. (annonaceae) has antidiabetic properties was investigated. diabetes mellitus was induced with streptozotocin-nicotinamide and graded doses of the aqueous leaf extracts were then administered in drinking water to normal and experimental diabetic rats for 12 days. fasting plasma glucose levels, serum insulin levels, serum lipid profiles and changes in body weight were ...200415036485
inhibitory effects of ent-kauranes from the stems of annona squamosa on superoxide anion generation by human neutrophils.eleven ent-kauranes, isolated from the fresh stems of annona squamosa l. (annonaceae), were subjected to assays on the generation of superoxide anion (o2.--) by human neutrophils. except for ent-kaur-16-en-19-oic acid, 16beta,17-dihydroxy- ent-kauran-19-al, and 16alpha,17-dihydroxy -ent-kauran-19-al, all ent-kauranes showed significant inhibitory effect on o2.-- generation in response to formyl- l-methionyl- l-leucyl- l-phenylalanine (fmlp/cb). in contrast, phorbol myristate acetate (pma)-induce ...200415114504
detection and determination of reticuline and n-methylcoculaurine in the annonaceae family using liquid chromatography-tandem mass spectrometry.in guadeloupe, the french west indies, there is a high incidence of atypical parkinsonism or progressive supranuclear palsy, and all of the investigated patients had taken herbal tea or tropical fruits of the annonaceae family. local inhabitants consume the fruits, and also drink tea made from the leaves. in the present study, we used liquid chromatography-tandem mass spectrometry (lc/ms/ms) with multiple reaction monitoring (mrm) to detect low-molecular-weight neurotoxic benzylisoquinoline deri ...200415149614
effect of herbal molluscicides and their combinations on the reproduction of the snail lymnaea acuminata.effects of sublethal treatment (20 and 60% of lc50/24 h) of the plant-derived molluscicides annona squamosa linn. and lawsonia inermis linn. and their combinations with other herbal molluscicides, such as cedrus deodara roxb, azadirachta indica a. juss, bulb powder of allium sativum linn. and polianthes tuberosa linn., and oleoresin of zingiber officinale rosc., and acetogenins extracted from the seeds of a. squamosa linn., on the reproduction of the snail lymnaea acuminata have been studied. it ...200415253044
evaluation of anthelmintic properties of some plants used as livestock dewormers against haemonchus contortus infections in sheep.gastrointestinal helminth infections remain a major constraint to livestock production globally. this study evaluated anthelmintic efficacy of 7 plants used as dewormers by farmers and pastoralists in kenya. thus 3 commercial anthelmintics and 7 plant preparations were tested in lambs infected with 5000 or 3000 l3 haemonchus contortus in 4 experiments. in the first experiment, ivermectin, levamisole and albendazole were tested in 46 lambs. seven plant preparations of hagenia abyssinica, olea eur ...200415376783
in vitro antioxidant studies of annona squamosa linn. leaves.the free radical scavenging potential of the leaves of a. squamosa was studied by using different antioxidant models of screening. the ethanolic extract at 1000 microg/ml showed maximum scavenging of the radical cation, 2,2-azinobis- (3-ethylbenzothiazoline-6-sulphonate) (abts) observed upto 99.07% followed by the scavenging of the stable radical 1,1-diphenyl, 2-picryl hydrazyl (dpph) (89.77 %) and nitric oxide radical (73.64%) at the same concentration. however, the extract showed only moderate ...200415573531
effect of binary combination of some plant-derived molluscicides with mgk-264 or piperonyl butoxide on the reproduction of the snail lymnaea acuminata.the effects of sub-lethal treatments (20 and 60% of 24-h lc(50)) with plant-derived molluscicides annona squamosa, acetogenins, argemone mexicana seed and protopine, in combination (1 + 5) with mgk-264 (ent 8184) or piperonyl butoxide on the reproduction of lymnaea acuminata has been studied. the plant-derived molluscicides and their active molluscicidal components, protopine and acetogenins, in combination with ent 8184 or piperonyl butoxide caused a significant reduction in the fecundity, hatc ...200515619718
preliminary studies on activity of ocimum sanctum, drynaria quercifolia, and annona squamosa against neisseria gonorrhoeae.despite the progressive increase of antimicrobial resistance of neisseria gonorrhoeae worldwide, there are limited reports of alternative remedies from plants.200515668617
hypoglycemic and antidiabetic effect of ethanolic extract of leaves of annona squamosa l. in experimental animals.the ethanolic extract of annona squamosa l. (annonaceae) leaves was administered orally at different doses to normal as well as streptozotocin (stz)-induced diabetic rats and alloxan-induced diabetic rabbits. the dose of 350 mg/kg body weight (bw) reduced the fasting blood glucose (fbg) level by 6.0% within 1 h, whereas, the peak blood glucose at 1 h during glucose tolerance test (gtt) was reduced by 17.1% in normal rats. the same dose of ethanolic extract reduced fbg by 26.8% and improved gluco ...200515848023
[chemical constituents from the seeds of annona squamosa].to study the antitumor active constituents of the seeds from annona squamosa l. (annonaceae).200515875673
differential cytotoxic effects of annona squamosa seed extracts on human tumour cell lines: role of reactive oxygen species and glutathione.annonaceous acetogenins are a new class of compounds that have been reported to have potent pesticidal, parasiticidal, anti-microbial, cell growth inhibitory activities. in this study, organic and aqueous extracts from the defatted seeds of annona squamosa (custard apple) were tested on different human tumour cell lines for antitumoural activity. while organic and aqueous extracts induced apoptosis in mcf-7 and k-562 cells, they failed to do so in colo-205 cells. treatment of mcf-7 and k-562 cel ...200515886460
antimicrobial and cytotoxic constituents from the seeds of annona squamosa.annotemoyin-1, annotemoyin-2, squamocin and cholesteryl glucopyranoside were isolated from the seeds of annona squamosa. these compounds and plant extracts showed remarkable antimicrobial and cytotoxic activities.200515964712
rain forest provides pollinating beetles for atemoya crops.small beetles, usually species of nitidulidae, are the natural pollinators of atemoya (annona squamosa l. x a. cherimola mill. hybrids; custard apple) flowers but commercial atemoya growers often need to carry out labor-intensive hand pollination to produce enough high-quality fruit. because australian rain forest has plant species in the same family as atemoya (annonaceae) and because many rain forest plants are beetle pollinated, we set out to discover whether tropical rain forest in far north ...200516156571
nutritional and hypoglycemic effect of fruit pulp of annona squamosa in normal healthy and alloxan-induced diabetic rabbits.the nutritive value of the pulp of the edible fruit of annona squamosa and its effect on various biochemical parameters has been assessed in normal and alloxan-induced diabetic rats. different doses (2.5, 5.0, 10.0 g/kg b.w.) of fresh fruit pulp of a. squamosa were given to the three groups each of normal healthy and diabetic rabbits orally daily for 1 month. there was a control group of normal as well as diabetic animals which did not receive fruit pulp. protein efficiency ratio (per), digestib ...200516230844
an anti-inflammatory ent-kaurane from the stems of annona squamosa that inhibits various human neutrophil functions.we have previously shown that 11 ent-kauranes isolated from the stems of annona squamosa exhibited immunomodulating effects in leukocytes. in this study, a cellular model using isolated human neutrophils, which are important in the pathogenesis of rheumatoid arthritis, ischemia-reperfusion injury, chronic obstructive pulmonary disease, asthma and other inflammatory diseases, was established in order to elucidate the anti-inflammatory functions of 16beta,17-dihydroxy-ent-kauran-19-oic acid (1). r ...200516254820
examination of some morphologically unusual cultures of phytophthora species using a mitochondrial dna miniprep technique and a standardised sporangium caducity assessment.using the mitochondrial dna miniprep technique, the identity of sixteen morphologically unusual cultures allocated to phytophthora nicotianae, phytophthora mexicana or phytophthora porri was determined by comparison with a library of mtdna band patterns obtained from reference cultures. seven cultures were identified as phytophthora nicotianae (including those assigned to phytophthora mexicana and phytophthora porri), six as strains of phytophthora palmivora with small, ovoid, weakly caducous sp ...199716284813
latex-vegetable syndrome due to custard apple and aubergine: new variations of the hevein symphony.an increasing number of vegetables with crossreactions to latex are being described in patients with latex-vegetable syndrome. we present two of these vegetables, custard apple linked in two previous cases with latex sensitisation, and aubergine, that had not been described up to now in patients with latex sensitisation. the diagnosis of both cases was based on the clinical history, positive skin prick test (spt) and specific ige to the offending vegetables, as well as to positive spt and specif ...200516433216
comparative efficacy of annona squamosa linn. and pongamia glabra vent. to azadirachta indica a. juss against mosquitoes. 200516457387
major volatile constituents of annona squamosa l. bark.the volatile constituents of annona squamosa l. bark were identified from the essential oil obtained by steam distillation and studied by gc/ms. six major components were identified as 1h-cycloprop(e)azulene (3.46%), germacrene d (11.44%), bisabolene (4.48%), caryophyllene oxide (29.38%), bisabolene epoxide (3.64%) and kaur-16-ene (19.13%). the oil was also screened for its antimicrobial activity, which exhibited a significant antimicrobial activity against bacillus subtilis and staphylococcus a ...200616753909
vasorelaxant activity of cyclic peptide, cyclosquamosin b, from annona squamosa.a cyclic octapeptide, cyclosquamosin b (2), isolated from the seeds of annona squamosa showed a vasorelaxant effect on rat aorta. it showed a slow relaxation activity against norepinephrine (ne)-induced contractions of rat aorta with/without endothelium. it showed inhibition effect on vasocontraction of depolarized aorta with high concentration potassium, but moderately inhibition effect on ne-induced contraction in the presence of nicardipine. these results showed that the vasorelaxant effect b ...200616784851
antidiabetic and antioxidant activity of annona squamosa extract in streptozotocin-induced diabetic rats.the aim of the study is to analyse the antioxidant effect of oral administration of aqueous extract of annona squamosa (a. squamosa) leaf on blood glucose, haemoglobin, glycosylated haemoglobin, plasma insulin, antioxidant enzymes and lipid peroxidation in liver and kidney to streptozotocin (stz)-induced diabetic rats.200616865205
ethnomedicines used in trinidad and tobago for urinary problems and diabetes mellitus.this paper is based on ethnobotanical interviews conducted from 1996-2000 in trinidad and tobago with thirty male and female respondents.200617040567
ascorbic acid contents of pakistani fruits and vegetables.fresh fruits and vegetables are good sources of vitamin c which is known for its antioxidant and immune-enhancing effects. the objective of this study was to determine ascorbic acid (vitamin c) contents of regularly consumed fruits and vegetables available in pakistani markets. most commonly used fresh fruits and vegetables were homogenized in 5% trichloroacetic acid, and ascorbic acid contents in the extracts were determined using a spectrophotometric method. banana, custard apple, orange, lemo ...200617105704
anti-head lice effect of annona squamosa seeds.the present study focused on the separation and identification of the active compounds against head lice from the hexane extract of annona squamosa l seed. chromatographic and spectroscopic techniques revealed that two major compounds of the hexane seed extract were oleic acid and triglyceride with one oleate ester. the yields of these compounds were 13.25% and 7.74% dry weight, respectively. the compounds were tested in vitro against head lice, comparing to the crude hexane extract of the seed. ...200617120975
[the relative configuration of acetogenins isolated from annona squamosa: annonin i (squamocin) and annonin vi].annonin i ( 1) and anonin vi ( 9) were isolated from the seeds of annona squamosa l. (annonaceae). the constitution of 1 is identical with that of squamocin, isolated by fujimoto et al. (8). the relative configuration of 1 was elucidated by x-ray diffraction analysis of a derivative. the constitution and relative configuration of 9 was established by (13)c- and (1)h-nmr spectroscopy using data of derivatives.199017221427
[annonacins and annonastatin from annona squamosa].annonacin ( 1), annonacin a ( 6), and annonastatin ( 7) were isolated from the seeds of annona squamosa l. (annonaceae). compounds 6 and 7 are described for the first time. the relative configuration of the tetrahydrofuran core of 1 (with hitherto unknown configuration), as well as those of compounds 6, and 7 were established by (13)c- and (1)h-nmr spectroscopy using data of the derivatives 8- 11.199017221428
isolation and antimicrobial evaluation of isomeric hydroxy ketones in leaf cuticular waxes of annona squamosa.a novel natural compound, 11-hydroxy-16-hentriacontanone, has been isolated from the leaf cuticular wax of annona squamosa along with its known isomer 10-hydroxy-16-hentriacontanone in a ratio of 67:33. this isomeric mixture of hydroxy ketones constituted together 16.5% of the total cuticular waxes. the new compound was characterised using spectral and chromatographic techniques. the major component was found to be 16-hentriacontanone (palmitone), which constituted up to 48% of the total cuticul ...201217260693
annona squamosa seed extract in the regulation of hyperthyroidism and lipid-peroxidation in mice: possible involvement of quercetin.annona squamosa (custard apple) seeds are generally thrown away as waste materials. the extract of these seeds was evaluated for its possible ameliorative effect in the regulation of hyperthyroidism in mouse model. serum triiodothyronine (t(3)), thyroxine (t(4)) concentrations, hepatic glucose-6-phospatase (g-6-pase) and 5'-mono-deiodinase (5'di) activity were considered as the end parameters of thyroid function. simultaneously hepatic lipid peroxidation (lpo), superoxide dismutase (sod) and cat ...200717291737
antioxidant activities of some local bangladeshi fruits (artocarpus heterophyllus, annona squamosa, terminalia bellirica, syzygium samarangense, averrhoa carambola and olea europa).in the present study, antioxidant activities of the fruits of a. heterophyllus, a. squamosa, t. bellirica, s. samarangense, a. carambola and o. europa were investigated. for this, at first matured fruits of them were sliced into small pieces and dried in the sun and finally crushed in a grinder to make powder. ethanolic extracts of fruit powder were prepared using 99.99% ethanol. the antioxidative activities of these extracts were determined according to their abilities of scavenging 1, 1-diphen ...200717460898
application of low-pressure gas chromatography/tandem mass spectrometry to the determination of pesticide residues in tropical fruits.a multiresidue method has been developed for determining pesticide residues in the tropical fruits kiwi, custard apple, and mango. the intended purpose of the method is for regulatory analyses of commodities for pesticides that have established maximum residue limits. a fast and simple extraction method with cyclohexane-ethyl acetate (1 + 1, v/v) and a high-speed homogenizer was optimized. pressurized liquid extraction was evaluated as an alternative automated extraction technique. the pesticide ...201217760354
new cyclic peptides from the seeds of annona squamosa l. and their anti-inflammatory activities.two new cyclic peptides, cyclosquamosin h ( 1) and i ( 2), together with six known cyclic peptides, squamin a ( 3), squamin b ( 4), cyclosquamosin a ( 6), cyclosquamosin d ( 7), cyclosquamosin e ( 8), and cherimolacyclopeptide b ( 9), were isolated from the seeds of annona squamosa. all structures were confirmed by 2d nuclear magnetic resonance, chemical evidence, and electrospray ionization-mass spectromotry/mass spectrometry (esi-ms/ms). compound 9 was isolated from this plant for the first ti ...200818072745
mono-tetrahydrofuran annonaceous acetogenins from annona squamosa as cytotoxic agents and calcium ion chelators.eight new mono-tetrahydrofuran (thf)-type annonaceous acetogenins, squafosacins b, c, f, and g (1-4), squadiolins a-c (5-7), and cis-annotemoyin-1 (8), as well as eight known annonaceous acetogenins, glabranin, annotemoyins-1 and -2, bullatencin, cis-bullatencin, and uvariamicins-i, -ii, and -iii, were isolated from the seeds of annona squamosa by hplc. the structures of all new isolates were elucidated by using spectroscopic and chemical methods. squadiolins a (5) and b (6) showed ng/ml potency ...200818419154
in vivo evaluation of anti-oxidant and anti-lipidimic potential of annona squamosa aqueous extract in type 2 diabetic models.diabetes is known to involve oxidative stress and changes in lipid metabolism. many secondary plant metabolites have been shown to possess antioxidant activities, improving the effects of oxidative stress due to diabetes. the present study was aimed to evaluate the effect of water extract of annona squamosa leaves on antioxidant enzymes and lipid profile of animal models of type 2, non-insulin dependent diabetes mellitus (niddm).200818440739
anthelmintic acetogenin from annona squamosa l. seeds.annona squamosa seeds extracts showed anthelmintic activity against haemonchus contortus, the main nematode of sheep and goat in northeastern brazil. a compound 1 was isolated from ethyl acetate extract and inhibited the egg hatching of h. contortus at 25 mg ml(-1). the structure of 1 was determined as a c37 trihydroxy adjacent bistetrahydrofuran acetogenin based on spectroscopic analysis.200818506253
lipoxygenase inhibition by novel fatty acid ester from annona squamosa seeds.studies on the seeds of annona squamosa yielded a novel lipoxygenase inhibitor fatty acid ester, (+) - annonlipoxy (1). compound 1 was screened for its enzyme inhibitory activity against lipoxygenase (e.c.1.14.18.1), exhibiting activity with ic(50) 69.05 +/- 5.06 microm. baicalein (ic(50) 22.6 +/- 0.5 microm) was used as a positive control. crude extracts of annona squamosa fruit pulp and seeds were screened for its enzyme inhibitory activity against lipoxygenase and acetylcholinesterase. the cr ...200818615286
larvicidal and adulticidal activities of some medicinal plants against the malarial vector, anopheles stephensi (liston).the present study was undertaken to test the efficacy of 11 commonly available medicinal plants and compare its efficacy in relation to larvicidal and mosquitocidal activities against larvae and adults of anopheles stephensi (liston). all the medicinal plants and the mixture were effective against larvae of a. stephensi as evidenced by low lethal concentration and lethal time. the lethality varied in adults and plant extracts of mixture; eucalyptus globulus, cymbopogan citratus, artemisia annua, ...200918787842
diversity of root associated microorganisms of selected medicinal plants and influence of rhizomicroorganisms on the antimicrobial property of coriandrum sativum.the total heterotrophic bacteria, actinomycetes and fungus were enumerated from the rhizosphere and non-rhizosphere soil of 50 selected locally available medicinal plants in and around bharathiar university. in all the plants, population of microorganism were higher in the rhizosphere soil than in the non rhizosphere soil. among the microorganisms, bacterial population was higher in number followed by fungus and actinomycetes. of the medicinal plants, the maximum rhizosphere effect was observed ...200818831345
beneficial effects of annona squamosa extract in streptozotocin-induced diabetic rats.the present study investigated the possible therapeutic effects of annona squamosa (a. squamosa) extract on certain biochemical markers in streptozotocin (stz)-induced diabetes mellitus in rats.200818946614
antidiabetic and antioxidative effects of annona squamosa leaves are possibly mediated through quercetin-3-o-glucoside.present investigation was made to reveal the involvement of a quercetin in the antidiabetic and antiperoxidative effects of annona squamosa leaf extract. quercetin-3-o-glucoside (characterized by uv, ir, ms and nmr analyses) was isolated from annona squamosa leaves and examined for its potential to regulate alloxan-induced hyperglycemia and lipid peroxidation (lpo) in rats. while in alloxan treated animals, an increase in the concentration of serum glucose with a parallel decrease in insulin lev ...200718997283
sugar profiles and soluble and insoluble dietary fiber contents of fruits in thailand markets.the objective of the present study was to determine sugar and dietary fiber contents in 37 varieties of thai fruits. sugars were determined by high-performance liquid chromatography and dietary fiber values were measured by the enzymatic-gravimetric method. the total sugar (sucrose, fructose and glucose) content ranged from 4.5 g/100 g (strawberry) to 20.3 g/100 g (ripe banana; hawm variety) edible portion. all varieties of ripe banana provided good sources of glucose, fructose and total sugar. ...200919255919
saturated long-chain hydrocarbons from annona squamosa l. bark.the unsaponified chloroform extract of annona squamosa l. bark has been analysed by gas chromatography-mass spectrometry (gc-ms) and was shown to consist of the conventional, even carbon number dominant distribution of saturated n-alkane homologues (c(14)-c(26)). the heptadecane (5.75%) was the only odd carbon number hydrocarbon. the total amount of hydrocarbons found in the unsaponified chloroform extract was 24.60%.200919296389
two new cytotoxic acetogenins from annona squamosa.two new annonaceous acetogenins named as squamostanin-a and squamostanin-b were isolated from 95% etoh extract of the seeds of annona squamosa. their structures were determined by spectroscopic method, and their cytotoxicities were evaluated using mtt method.200919408149
in vivo assessment of genotoxic effects of annona squamosa seed extract in rats.widespread use of pesticides represents a potential risk to human and environmental health. hence, biopesticides from plants are some of the future strategies for plant protection. in this regard, a seed extract of annona squamosa was prepared and found to be a promising pesticide. in order to establish the inherent toxicity and non-target safety required for registration and marketing of pesticides, toxicological studies are conducted. the genotoxicity potential was evaluated in rats with 75, 1 ...200919457440
larvicidal and igr activity of extract of tanzanian plants against malaria vector mosquitoes.this paper reports the larvicidal activity of seventeen tanzanian plant species against the malaria vector, anopheles gambiae s.s. giles larvae. some of the plants are used traditionally as sources of insecticidal materials.200919502695
new nonadjacent bis-thf ring acetogenins from the seeds of annona squamosa.two new annonaceous acetogenins named as squamostanin-c and squamostanin-d were isolated from 95% etoh extract of the seeds of annona squamosa. their structures were determined by spectroscopic method, and their cytotoxicities were evaluated by using mtt method.200919535019
comparative efficacy of annona squamosa and azadirachta indica extracts against boophilus microplus izatnagar isolate.in the search of developing herbal acaricides, eight medicinal plants were screened for their efficacy against boophilus microplus, the widely distributed tick species in india. of the seven extracts screened, the extracts prepared from the annona squamosa seed showed very high level of efficacy (70.8%) after 24 h of treatment. the effect of treatment on oviposition of the survived ticks was also assessed, and a significant reduction (p < 0.05) in the reproductive index was noted in comparison t ...200919557436
biosensor for chlorogenic acid based on an ionic liquid containing iridium nanoparticles and polyphenol oxidase.a biosensor based on the ionic liquid, 1-n-butyl-3-methylimidazolium hexafluorophosphate containing dispersed iridium nanoparticles (ir-bmi.pf(6)) and polyphenol oxidase was constructed. this enzyme was obtained from the sugar apple (annona squamosa), immobilized in chitosan ionically crosslinked with oxalate. the biosensor was used for determination of chlorogenic acid by square wave voltammetry. the polyphenol oxidase catalyzes the oxidation of chlorogenic acid to the corresponding o-quinone, ...200919559869
analgesic and anti-inflammatory activity of caryophyllene oxide from annona squamosa l. bark.caryophyllene oxide was isolated from an unsaponified petroleum ether extract of the bark of annona squamosa and studied for its analgesic and anti-inflammatory activity. caryophyllene oxide at the doses of 12.5 and 25mg/kg body wt. and unsaponified petroleum ether extract at a dose of 50mg/kg body wt. showed significant central as well as peripheral analgesic, along with anti-inflammatory, activity. these activities of caryophyllene oxide were comparable with the standard drug used in the respe ...201019576741
control of silverleaf whitefly, cotton aphid and kanzawa spider mite with oil and extracts from seeds of sugar apple.development of alternative methods for pest management is needed with the increased concern for adverse effects of pesticides for human health and the environment. the main goal of our study was to test the oil from seeds of sugar apple (annona squamosa), an edible tropical fruit for pest control. the oil pressed out of seeds was as effective in controlling the silverleaf whitefly, bemisia argentifolii bellows & perring (homoptera: aleyrodidae), infesting leaves of tomato plants in greenhouse co ...200919768275
adulticidal and larvicidal efficacy of some medicinal plant extracts against tick, fluke and mosquitoes.the adulticidal and larvicidal effect of indigenous plant extracts were investigated against the adult cattle tick haemaphysalis bispinosa neumann, 1897 (acarina: ixodidae), sheep fluke paramphistomum cervi zeder, 1790 (digenea: paramphistomatidae), fourth instar larvae of malaria vector, anopheles subpictus grassi and japanese encephalitis vector, culex tritaeniorhynchus giles (diptera: culicidae). the aim of this study was to evaluate the toxic effect of leaf hexane, chloroform, ethyl acetate, ...200919819626
protective role of annona squamosa linn bark extracts in dmba induced genotoxicity.there has been no dearth of scientific literature that genotoxic agents have a causative effect in the pathogenesis of carcinomas. 7,12 dimethylbenz(a)anthracene (dmba), which is a potent organ specific carcinogen, has been found to produce mutagenic effects on cells. annona squamosa has a long history in traditional indian medicine for being used to treat several diseases including cancer.200820071820
[biology of tetranychus mexicanus (mcgregor) (acari: tetranychidae) on three species of annonaceae].the mite tetranychus mexicanus (mcgregor) is considered a pest of a variety of plant species in the americas. although this mite apparently causes economic damage to annonaceae, little is known about its biology. here we studied the biology of t. mexicanus on soursop (annona muricata), sweetsop (annona squamosa) and araticum (annona coriaceae). the first two species are the most important economical annonaceae species in northeast brazil; araticum is commonly found in the region, but not commerc ...201020676502
parallel synthesis and anti-inflammatory activity of cyclic peptides cyclosquamosin d and met-cherimolacyclopeptide b and their analogs.we report the parallel synthesis of two natural cyclopeptides, isolated from the seeds of annona squamosa, cyclosquamosin d (a1), and met-cherimolacyclopeptide b (b) and their analogs. all of the compounds were screened for anti-inflammatory activity by evaluating their inhibitory effects on the production of pro-inflammatory cytokines using the lipopolysaccharide stimulated macrophage j774a.1 cell line. compounds having significant anti-inflammatory activity in suppressing the secretion of il-6 ...201020801649
in vitro antimalarial activity of medicinal plant extracts against plasmodium falciparum.malaria is a major global public health problem, and the alarming spread of drug resistance and limited number of effective drugs now available underline how important it is to discover new antimalarial compounds. in the present study, ten plants were extracted with ethyl acetate and methanol and tested for their antimalarial activity against chloroquine (cq)-sensitive (3d7) and cq-resistant (dd2 and indo) strains of plasmodium falciparum in culture using the fluorescence-based sybr green assay. ...201120809417
analgesic and anti-inflammatory activities of 18-acetoxy-ent-kaur-16-ene from annona squamosa l. bark.the annona squamosa l. bark was collected from ahmednagar district, india. 18-acetoxy-ent-kaur-16-ene was isolated from petroleum ether extract (pe) and studied for its analgesic and anti-inflammatory activities. 18-acetoxy-ent-kaur-16-ene at the doses of 12.5 and 25 mg/kg, and pe at a dose of 50 mg/kg exhibited significant analgesic along with anti-inflammatory activity.201020957519
larvicidal efficacy of medicinal plant extracts against anopheles stephensi and culex quinquefasciatus (diptera: culicidae).mosquitoes transmit serious human diseases, causing millions of deaths every year. natural products of plant origin with insecticidal properties have been used in recent years for control of a variety of pest insects and vectors. the present study was based on assessments of the larvicidal activity to determine the efficacies of hexane, chloroform, ethyl acetate, acetone and methanol extracts of ten medicinal plants tested against fourth instar larvae of malaria vector, anopheles stephensi listo ...201020962718
efficacy of anthelmintic properties of medicinal plant extracts against haemonchus contortus.the development of anthelmintic resistance has made the search for alternatives to control gastrointestinal nematodes of small ruminants imperative. among these alternatives are several medicinal plants traditionally used as anthelmintics. this present work evaluated the efficacy of ethyl acetate, acetone, and methanol dried leaf and seed extracts of five medicinal plants were tested in vitro ovicidal and larvicidal activities on haemonchus contortus. the in vitro assay was based on egg hatch as ...201020980034
anthelmintic activity of botanical extracts against sheep gastrointestinal nematodes, haemonchus contortus.the source of chemical anthelmintics (levamisole, flubendazole, and thiabendazole) had limited the success of gastrointestinal nematodiasis control in sheep and goats and thus awakened interest in the study of medicinal plant extracts as alternative sources of anthelmintics. the egg hatching and larvicidal effect of indigenous plant extracts were investigated against the sheep parasite, haemonchus contortus. the purpose of the present study was to assess the efficacy of leaf, bark, and seed ethy ...201021161270
anti-ulcer constituents of annona squamosa twigs.phytochemical investigation of annona squamosa twigs, resulted in isolation and identification of twelve known (1-12) compounds among them one 1-(4-ß-d-glucopyranosyloxyphenyl)-2-(ß-d-glucopyranosyloxy)-ethane (11) is synthetically known but first time isolated from natural sources. their structures were elucidated using 1d and 2d nmr spectroscopic analysis. the isolated compounds (2-8, 11) were evaluated for h(+) k(+)-atpase activity. three of these compounds (+)-o-methylarmepavine (2), n-methy ...201121342663
seedless fruits and the disruption of a conserved genetic pathway in angiosperm ovule development.although the biological function of fruiting is the production and dissemination of seeds, humans have developed seedless fruits in a number of plant species to facilitate consumption. here we describe a unique spontaneous seedless mutant (thai seedless; ts) of annona squamosa (sugar apple), a member of the early-divergent magnoliid angiosperm clade. ovules (seed precursors) of the mutant lack the outer of two normal integuments, a phenocopy of the inner no outer (ino) mutant of arabidopsis thal ...201121402944
protective effect of methanolic extract of annona squamosa linn in isoniazid-rifampicin induced hepatotoxicity in rats.the present study was made to investigate the protective effect of methanolic extract of annona squamosa on isoniazid-rifampicin-induced hepatotoxicity in rats. rats were divided into five different groups (n=6), group 1 served as a control, group 2 received isoniazid (100 mg/kg, i.p.) and co-administered with rifampicin (100 mg/kg, i.p.), in sterile water, group 3 and 4 served as extract treatment groups and received 250 & 500 mg/kg bw, p.o methanolic extract of annona squamosa and group 5 serv ...201121454160
toxicity of botanical insecticides on golden apple snail (pomacea canaliculata).the molluscicidal activity of crude extracts from five highly potential plants, annona squamosa seed, nerium indicum leaves, stemona tuberose root, cyperus rotundus corm and derris elliptica root was assessed to pomacea canaliculata. d. elliptica root and c. rotundus corm extracts showed the highest toxicity against 3-month old snails which have lc50 as 23.68 +/- 2.96 mg/l and 133.20 +/- 7.94 mg/l, respectively. the c. rotundus corm extracts were chosen for detoxification enzyme in vivo assay wh ...201021542482
effects of thai medicinal herb extracts with anti-psoriatic activity on the expression on nf-κb signaling biomarkers in hacat keratinocytes.psoriasis is a chronic inflammatory skin disorder characterized by rapid proliferation of keratinocytes and incomplete keratinization. discovery of safer and more effective anti-psoriatic drugs remains an area of active research at the present time. using a hacat keratinocyte cell line as an in vitro model, we had previously found that ethanolic extracts from three thai medicinal herbs, namely alpinia galanga, curcuma longa and annona squamosa, possessed anti-psoriatic activity. in the current s ...201121555979
antiplasmodial potential of medicinal plant extracts from malaiyur and javadhu hills of south india.the emergence and spread of plasmodium falciparum with resistance to chloroquine (cq), the safest and cheapest anti-malarial drug, coupled with the increasing cost of alternative drugs especially in developing countries have necessitated the urgent need to tap the potential of plants for novel anti-malarials. the present study investigates the anti-malarial activity of the methanolic extracts of 13 medicinal plants from the malaiyur and javadhu hills of south india against blood stage cq-sensiti ...201121643655
secondary metabolites of pyrenochaeta sp. b36, an endophytic fungus from annona squamosa l.four new metabolites, named pyrenochaetamide a, pyrenochaetolide a, pyrenochaetoxy a and pyrenochaetolide b, together with five known compounds, were isolated from strain pyrenochaeta sp. b36, an endophytic fungus of annona squamosa l. their structures were elucidated by spectroscopic analyses including 1d- and 2d-nmr (hmqc, hmbc, ¹h-¹h cosy and noesy) and hrft-ms. the cytotoxic activities of these compounds were evaluated and some of them showed substantial effect.201121644182
larvicidal activity of medicinal plant extracts against anopheles subpictus & culex tritaeniorhynchus.background & objectives: mosquitoes transmit serious human diseases, causing millions of deaths every year and the development of resistance to chemical insecticides resulting in rebounding vectorial capacity. plants may be alternative sources of mosquito control agents. the present study assessed the role of larvicidal activities of hexane, chloroform, ethyl acetate, acetone, and methanol dried leaf and bark extracts of annona squamosa l., chrysanthemum indicum l., and tridax procumbens l. agai ...201121808141
floral development and floral phyllotaxis in anaxagorea (annonaceae).background and aims anaxagorea is the phylogenetically basalmost genus in the large tropical annonaceae (custard apple family) of magnoliales, but its floral structure is unknown in many respects. the aim of this study is to analyse evolutionarily interesting floral features in comparison with other genera of the annonaceae and the sister family eupomatiaceae. methods live flowers of anaxagorea crassipetala were examined in the field with vital staining, liquid-fixed material was studied with sc ...201121821626
antibacterial activity of three medicinal thai plants against campylobacter jejuni and other foodborne pathogens.leaves of adenanthera pavonina, moringa oleifera and annona squamosa are used in traditional thai medicine to treat dysentery and other diseases. this study investigated the antibacterial activity of these plants against six species of foodborne pathogen. methods and solvents employed to extract active constituents were optimised using the disc diffusion assay. phytochemical analysis of the optimised extracts was performed by thin layer chromatography (tlc). minimum inhibitory concentrations (mi ...201121878033
nematicidal and antifungal activities of annonaceous acetogenins from annona squamosa against various plant pathogens.the methanol extract of annona squamosa seeds was highly active against two phytoparasitic nematodes, bursaphelenchus xylophilus and meloidogyne incognita. it efficiently suppressed plant diseases, caused by phytophthora infestans and puccinia recondita. ten annonaceous acetogenins (aas) were isolated, and their chemical structures were identified by mass and nuclear magnetic resonance spectral data. out of 10 substances, eight displayed strong in vitro nematicidal activity against b. xylophilus ...201121910504
evaluation of enzymes inhibition activities of medicinal plant from burkina faso.the aim of the present study was to evaluate some enzymes inhibitory effects of 11 plant species belonging to 9 families from burkina faso. methanolic extracts were used for their glutathione-s-transferase (gst), acetylcholinesterase (ache), carboxylesterase (ces) and xanthine oxidase (xo) inhibitory activities at final concentration of 100 microg ml(-1). the total phenolics, flavonoids and tannins were also determined spectrophotometrically using folin-ciocalteu, alcl3 and ammonium citrate iron ...201121916259
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