Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| studies on the composition of milk with the use of neem seed expeller cake (az adirachta indica) on lactating buffaloes. | 1979 | 573242 | |
| cardiovascular effects of azadirachta indica extract. | a crude extract of the leaves of azadirachta indica was studied for its effects on the cardiovascular system of anesthetized guinea pigs and rabbits. these effects include profound hypotension and a minimal negative chronotropic effect, which increased at higher doses. in one rabbit, 200 mg of extract/kg decreased the heart rate from 280 to 150 beats/min. the extract also exhibited a weak antiarrhythmic activity in rabbits against ouabain-induced dysrhythmia. | 1978 | 702308 |
| suspected contaminated margosa oil poisoning. | 1978 | 750889 | |
| studies on plant gums: part iii--isolation & characterization of a glycopeptide from neem (azadirachta indica) gum after pronase digestion. | 1978 | 753744 | |
| [margosa bark extract for inflammatory mucous membrane diseases]. | 1976 | 1077013 | |
| mitochondrial malate dehydrogenase and malic enzyme of a filarial worm setaria digitata: some properties and effects of drugs and herbal extracts. | mitochondrial malate dehydrogenase (mmdh) and malic enzyme (mme) of a filarial worm setaria digitata were studied. mmdh exhibited the highest activities in the oxidation and reduction reactions at ph 9.5 and ph 6.2, respectively, while mme did so in the malate decarboxylation reaction at ph 6.8. mme showed no detectable activity on the pyruvate carboxylation direction. the km values for malate (1.7 mm) and oxaloacetate (0.17 mm) and the ratio of vmax oxidation: vmax reduction (2.73) tend to favo ... | 1992 | 1291764 |
| effects of azadirachta indica a juss on some biochemical, immunological and visceral parameters in normal and stressed rats. | effects of a. indica (ai) were evaluated on some biochemical, immunological and visceral parameters in normal and stress rats. ai (100 mg/kg) lowered blood glucose, triglyceride and sgot levels in normal rats, and attenuated stress-induced elevations of cholesterol and urea levels. in rats immunized with srbc, ai enhanced the humoral antibody response to the antigen. further, ai facilitated the footpad thickness response to srbc in sensitized mice and also enhanced leucocyte migration in immuniz ... | 1992 | 1294481 |
| "antimalarial" medicinal plants and their impact on cell populations in various organs of mice. | we have investigated the effects of leaf and bark decoctions of ocimum gratissimum, azadirachta indica, morinda lucida and enantia chlorantha on (a) the course of plasmodium yoelii nigeriensis malaria (b) reticulocyte and haematocrit values and (c) nucleated cell numbers in the spleen, bone marrow, peritoneum, liver and peripheral blood of swiss albino mice. results obtained showed that normal mice infected with the parasite (10(4)/mouse) suffered fulminant parasitaemia which resulted in death, ... | 1992 | 1308080 |
| effects of azadirachtin on rhodnius prolixus: immunity and trypanosoma interaction. | the effects of azadirachtin, a tetranortriterpenoid from the neem tree azadirachta indica j., on both immunity and trypanosoma cruzi interaction within rhodnius prolixus and other triatomines, were presented. given through a blood meal, azadirachtin affected the immune reactivity as shown by a significant reduction in numbers of hemocytes and consequently nodule formation following challenge with enterobacter cloacae beta 12, reduction in ability to produce antibacterial activities in the hemoly ... | 1992 | 1342719 |
| immunomodulatory effects of neem (azadirachta indica) oil. | immunomodulatory effects of neem oil were studied in mice. the animals were treated intraperitoneally (i.p.) with neem oil; control animals received the emulsifying agent with or without peanut oil. peritoneal lavage, collected on subsequent days, showed a maximum number of leukocytic cells on day 3 following treatment with neem oil; peritoneal macrophages exhibited enhanced phagocytic activity and expression of mhc class-ii antigens. neem oil treatment also induced the production of gamma inter ... | 1992 | 1452404 |
| hepatoprotective activity of azadirachta indica leaves on paracetamol induced hepatic damage in rats. | effect of a. indica leaf extract on serum enzyme levels (glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, acid phosphatase and alkaline phosphatase) elevated by paracetamol in rats was studied with a view to observe any possible hepatoprotective effect of this plant. it was interesting to observe that serum enzyme levels were much elevated in paracetamol induced animals than in those receiving a combination of paracetamol and lead extract. it is stipulated that the extract t ... | 1992 | 1459654 |
| evaluation of neem, azadirachta indica, with and without water management, for the control of culicine mosquito larvae in rice-fields. | applications of neem, azadirachta indica (meliaceae), to rice-fields were evaluated with the dual objective of controlling the culicine mosquito vectors of japanese encephalitis virus (jev) and enhancing the grain yield. since crude neem products deteriorate under improper storage conditions, a laboratory bioassay was developed to screen neem cake powder against mosquito larvae, culex quinquefasciatus. only samples of neem giving over 90% bioassay mortality were used in field trials. when good q ... | 1992 | 1463896 |
| the use and efficacy of azadirachta indica adr ('neem') and curcuma longa ('turmeric') in scabies. a pilot study. | in the ayurvedha and sidha system of medicine (indian system of medicine) azadirachta indica adr ('neem') and curcuma longa ('turmeric') has been used for healing chronic ulcers and scabies. the 'neem' and 'turmeric' was used as a paste for the treatment of scabies in 814 people. in 97% of cases cure was obtained within 3 to 15 days of treatment. we find that this is a very cheap, easily available, effective and acceptable mode of treatment for the villagers in the developing countries. we have ... | 1992 | 1496714 |
| on the toxicology of azadirachta indica leaves. | brown hisex chicks were fed diets containing 2% and 5% azadirachta indica leaf from their 7th to 35th day of age. thereafter, the chicks were fed control diet for 2 weeks. a depression in body weight gain and efficiency of feed utilization was observed in chicks fed a. indica leaf when compared with the control. the main clinicopathological changes were increases in lactic dehydrogenase, glutamic oxaloacetic transaminase and alkaline phosphatase activities and uric acid and bilirubin concentrati ... | 1992 | 1548899 |
| village pharmacy. the neem tree yields products from pesticides to soap. | 1992 | 1566036 | |
| constituents of azadirachta indica: isolation and structure elucidation of a new antibacterial tetranortriterpenoid, mahmoodin, and a new protolimonoid, naheedin. | mahmoodin [1], a new limonoid, has been isolated from azadirachta indica (neem) oil, along with seven known tetranortriterpenoids, azadirone, epoxyazadiradione, nimbin, gedunin, azadiradione, deacetylnimbin, and 17-hydroxyazadiradione. a new protolimonoid, naheedin [3], has been obtained from the neem fruits along with azadirachtol. their structures have been elucidated through chemical and spectral analyses including 2d nmr studies. the absolute configuration of 1 was established by comparison ... | 1992 | 1593280 |
| experimental azadirachta indica toxicosis in chicks. | brown hisex chicks were fed azadirachta indica ripe fruit at 2, 5 or 10% of basic diet from their 7th to 35th d of age. decreased body weight gain and efficiency of feed utilization and hepatonephropathy were most severe in chicks fed the 10% a indica diet. these changes were accompanied by anemia and increases in ldh, got and alp activities and uric acid concentration and by decreased serum total protein. hepatocytes and renal tubular cells did not completely revert to normal 2 w after removal ... | 1992 | 1609490 |
| ethnopharmacognostical survey of azadirachta indica a. juss (meliaceae). | literature data on respectively botany, chemistry, ethnopharmacology, pharmacology and toxicology of azadirachta indica a. juss. (meliaceae) are reviewed and evaluated. in traditional literature, preparations of the tree are claimed to be vulnerable in wide spectrum of diseases. especially for inflammation-related diseases a good correlation is found with the results of recent experimental investigations. in addition, a variety of other biological activities are reported. most frequently the eff ... | 1991 | 1753794 |
| antifertility activity of volatile fraction of neem oil. | nim-76, the odorous and volatile fraction of neem oil, was investigated for its antifertility activity in vivo in rats, rabbits and rhesus monkeys. the drug is effective when applied before coitus but not so when applied during post-coital stages. it, therefore, appears to act mainly by its spermicidal effect. no alteration in the estradiol (e2) and progesterone (p) values was observed after the application of the drug in monkeys. | 1991 | 1764946 |
| neem oil--a fertility controlling agent in rhesus monkey. | neem oil, an oil extracted from the seeds of azadirachta indica has been found to act as a good spermicidal agent. pre and post coital application of the oil intravaginally prevented pregnancy in rhesus monkey. | 1991 | 1812107 |
| effects of azadirachtin in rhodnius prolixus: data and hypotheses. | the effects of azadirachtin a, a tetranortriterpenoid from the neem tree azadirachta indica j., on both development and interaction between trypanosoma cruzi, the causative agent of chagas' disease, and its vector rhodnius prolixus were studied. given through a blood meal, a dose-response relationship of azadirachtin was established using antifeedant effect and ecdysis inhibition as effective parameters. a single dose of azadirachtin a was able to block the onset of mitosis in the epidermis and ... | 1991 | 1841982 |
| barrier contraceptives, spermicides, and periodic abstinence. | although barrier contraceptives were among the first methods of preventing unwanted pregnancy ever described for human use, with the advent of the non-coitally related oral contraceptives and intrauterine devices, they gradually fell into relative disuse. however, for a variety of reasons, this is no longer the case. there is a renewed interest in these techniques both as a major form of birth control and also as our best protection against the transmission of sexually transmitted diseases, many ... | 1991 | 1878503 |
| antifertility effects of neem (azadirachta indica) oil by single intrauterine administration: a novel method for contraception. | a novel use of neem (azadirachta indica) oil, a traditional plant product, for long-term and reversible blocking of fertility after a single intrauterine application is described. female wistar rats of proven fertility were given a single dose (100 microliters) of neem oil by intrauterine route; control animals received the same volume of peanut oil. whereas all control animals became pregnant and delivered normal litters, the rats treated with neem oil remained infertile for variable periods ra ... | 1990 | 1983033 |
| activity-guided isolation and identification of azadirachta indica bark extract constituents which specifically inhibit chemiluminescence production by activated human polymorphonuclear leukocytes. | the a. indica crude aqueous bark extract inhibits the generation of chemiluminescence by activated human polymorphonuclear leukocytes (pmn). guided by this activity the responsible compounds were purified by extraction with different organic solvents and hplc. gallic acid, (+)-gallocatechin, (-)-epicatechin, and (as a 2:1 mixture) (+)-catechin and epigallocatechin were isolated and identified by means of hplc, tlc, ms, 1h-nmr, uv, and cd data. commercial samples of gallic acid, (+)-catechin and ... | 1991 | 2062961 |
| synthesis of antifeedants for insects: novel behaviour-modifying chemicals from plants. | the need to protect our food supply from predatory insect attack using more ecologically acceptable methods has led to a rapidly growing interest in behavior-modifying chemicals from natural sources. compounds which deter insects from feeding (antifeedants) are attracting special attention owing to their potential use in integrated pest control management systems. we have been studying the synthesis of plant-derived compounds that display antifeedant properties. the aim of the work is to underst ... | 1990 | 2086043 |
| effect of azadirachtin on mesocyclops leuckarti sensu lato, vector of dracunculiasis. | extension or otherwise of characteristic insect development inhibitory effects of the neem sesquiterpenoid azadirachtin have been examined on eggs and nauplii of the crustacean cyclops, m. leuckarti sensu lato, a major vector of guineaworm disease at 0.1 ppm and above doses. azadirachtin reduced survival of early nauplii (n1 to n3) at 0.1 ppm and above doses. no such effect was observed when eggs and late nauplii (n4 to n5) were exposed. azadirachtin did not affect the moult cycle when late naup ... | 1990 | 2151143 |
| antifertility effects of leaf extracts of some plants in male rats. | ethanolic leaf extracts of different local folklore plants (azadirachta indica, beaumontia grandiflora, chordia dichotoma, casiarea tomentosa, diospyros embryopteris, milletia auriculata and melia azedarach) were investigated for antifertility effects on male rats in oral doses of 100 mg/kg daily for 21 days. though, none of these extracts interfered with spermatogenesis, anti-implantational and abortifacient effects were observed in females mated by the males fed with leaf extracts of a. indica ... | 1990 | 2253961 |
| volatile fraction of neem oil as a spermicide. | the volatile, odorous fraction of neem oil coded as nim-76 obtained by steam distillation was investigated for in vitro spermicidal activity. the data showed that the minimum concentration which inhibited spermatozoal motility was 0.25 mg/ml for rat and 25 mg/ml for human spermatozoa. the effect of the drug on spermatozoal motility was found to be dose-dependent. the activity of this drug was not altered in the presence of vaginal or cervical mucus. intra-vaginal application of nim-76 in rabbits ... | 1990 | 2257744 |
| margosa oil poisoning as a cause of toxic encephalopathy. | margosa oil is an extract of the seed of the neem tree and is widely used as a traditional medicine by indians in india, sri lanka, burma, thailand, malaysia and indonesia. used mainly for external applications, it is often administered orally to neonates and infants regularly in small amounts. margosa oil causes toxic encephalopathy particularly in infants and young children. the usual features are vomiting, drowsiness, tachypnea and recurrent generalised seizures. leucocytosis and metabolic ac ... | 1990 | 2259944 |
| plant products as protective agents against cancer. | out of various spices and leafy vegetables screened for their influence on the carcinogen-detoxifying enzyme, glutathione-s-transferase (gst) in swiss mice, cumin seeds, poppy seeds, asafoetida, turmeric, kandathipili, neem flowers, manathakkali leaves, drumstick leaves, basil leaves and ponnakanni leaves increased gst activity by more than 78% in the stomach, liver and oesophagus, - high enough to be considered as protective agents against carcinogenesis. glutathione levels were also significan ... | 1990 | 2283166 |
| evaluation of the possible role of glucose, carnitine, coenzyme q10 and steroids in the treatment of reye's syndrome using the margosa oil animal model. | glucose and steroids have been used in the treatment of children with reye's syndrome, while carnitine and coenzyme q10 have been the subject of some recent studies which suggest that these agents may have a role in the treatment of reye's syndrome and reye-like syndrome due to margosa oil poisoning. because of the paucity of causes of reye's syndrome seen at any one centre, the clinical variability of the disease, and limited knowledge of definite aetiologic factors, controlled clinical trials ... | 1990 | 2288230 |
| properties and potential of natural pesticides from the neem tree, azadirachta indica. | 2008 | 2405771 | |
| effects of drugs and fatty acids related to reye syndrome on brain water content in rats. | brain water content was measured by gas-chromatography in rats following intraperitoneal injection of drugs and fatty acids related to the etiology of reye syndrome. a statistically significant increase in brain water content was observed following injection of 5% glucose solution, valproic acid, acetyl salicylic acid, calcium hopantenate, margosa oil, 4-pentenoic acid, linolenate and arachidonate. seizures occurred in all animals given valproic acid, margosa oil and 4-pentenoic acid, and in 25% ... | 1989 | 2516690 |
| animal model of margosa oil ingestion with reye-like syndrome. pathogenesis of microvesicular fatty liver. | the aetiology and pathogenesis of reye's syndrome (rs) are incompletely understood. a number of environmental toxins and biological agents, including viruses, have been postulated to cause rs, either acting alone or synergistically. most investigations have suggested that the primary insult is in the liver mitochondria, leading to a complex biochemical catastrophe, with death from encephalopathy. margosa oil (mo), a long-chain fatty acid compound, has been shown to cause a reye-like syndrome wit ... | 1989 | 2593049 |
| azadirachtin as a larvicide against the horn fly, stable fly, and house fly (diptera: muscidae). | effects of azadirachtin, a triterpenoid extracted from neem seed, azadirachta indica a. juss., were similar to those of insect growth regulators against the immature stages of the born fly, haematobia irritans (l.), the stable fly, stomoxys calcitrans (l.), and the house fly, musca domestica l. when an ethanolic extract of ground seed was blended into cow manure, lc50 and lc90's for larval horn flies were 0.096 and 0.133 ppm azadirachtin, respectively. an emulsifiable concentrate (ec) had an lc5 ... | 1989 | 2600264 |
| isolation and characterization of an antimalarial agent of the neem tree azadirachta indica. | the isolation and structure elucidation of gedunin [1], the antimalarial agent of azadirachta indica, are reported. its 1h- and 13c-nmr spectra were assigned by using one- and two-dimensional nmr spectroscopy, especially homonuclear and heteronuclear cosy, noe difference, and coloc experiments. | 2006 | 2607354 |
| spectroscopic and biological investigation of nimbolide and 28-deoxonimbolide from azadirachta indica. | the reisolation of nimbolide [1] from azadirachta indica of tanzanian origin and the isolation and structure elucidation of a new limonoid, 28-deoxonimbolide [2], from the same plant source are reported. for the first time, unambiguous 1h- and 13c-nmr assignments of compounds 1 and 2 are presented, as well as their in vitro cytotoxic activity against human tumor cell lines. | 1989 | 2614419 |
| characterization of anti-complement compounds from azadirachta indica. | the crude aqueous extract of azadirachta indica bark possesses an inhibitory activity on both classical (cp) and alternative pathway (ap) activation of human complement. purification of the compounds with the guidance of the ap-inhibitory activity involved extraction with methanol, dialysis, ion-exchange procedures and gel-permeation chromatography. this sequence yielded two polymers, nb-i and nb-ii, one a highly active compound with a relatively low molecular weight (nb-ii) and the other a less ... | 1989 | 2615417 |
| [anti-infective phytotherapies of the tree-savannah, senegal (occidental africa). iii: a review of phytochemical substances and the antimicrobial activity of 43 species]. | a review has been made of the ethnobotanical and pharmacological data of 43 medicinal plants of the tree-savannah used by the diola against infectious diseases. the traditional use of ten plants can be explained by pharmacologically active principles: adansonia digitata, azadirachta indica, carica papaya, cassia tora, fagara leprieurii, guiera senegalensis, khaya senegalensis, mangifera indica, psidium guajava and voacanga africana. four of these herbs are recommended for use in primary health c ... | 1989 | 2664354 |
| an ethnopharmacognostic approach to the search for immunomodulators of plant origin. | the search for immunomodulating plant constituents through basic and field inquiries into the literature and practices of traditional indian medicine is treated. the strategy of data collecting proceeds through aspects of an ethnobotanical, an ethnopharmaceutical, an ethnopharmacological, and an ethnomedical nature. in the experimental immunopharmacognostic phase, immunomodulatory compounds are isolated and purified through action-guided fractionation procedures. the results described here refer ... | 1989 | 2682699 |
| studies on in vitro degradation and in vivo digestion of a slow ammonia releasing urea product. | a slow ammonia releasing urea product (uromalt) has been produced by autoclaving and drying of germinated barley and urea. in vitro degradability of nitrogen (ivdn, raab et al., 1983) was in average 62 +/- 9% in 4 hours, compared to 76 +/- 8% with an autoclaved and dried mixture of urea and not-germinated barley. mixtures of urea with leucaena l. or azadarichta indica (neem cake) showed degradabilities of about 80 and 93%, respectively, when dried at 39 degrees c, but of 65% when dried at 100 de ... | 1989 | 2735818 |
| biochemical and histological studies of reproductive organs in cyclic and ovariectomized rats supporting a non-hormonal action for neem oil. | subcutaneous administration of neem oil to cyclic rats caused significant damage to the luminal epithelium of the uterus and to the uterine glands. it also decreased glycogen and total protein contents in the ovary and uterus, while the activity of acid phosphatase in these organs was increased significantly. studies in ovariectomized rats revealed that the administration of neem oil decreased protein and glycogen content and increased acid phosphatase activity in the uterus whereas its conjoint ... | 1989 | 2747262 |
| effects of peroxidized polyunsaturated fatty acids on mitochondrial function and structure: pathogenetic implications for reye's syndrome. | linoleic acid, a polyunsaturated fatty acid, is a constituent of margosa oil which has been implicated as a cause of reye's syndrome (rs) in infants. increased concentrations of polyunsaturated fatty acids have been found in sera from patients with rs. isolated rat liver mitochondria exposed to the peroxidized (but not unperoxidized) methyl esters of linoleic (c18:2) or linolenic (c18:3) acids showed decreases in state 3 and uncoupled respiratory rates and in respiratory control and adp/o ratios ... | 1988 | 2900617 |
| evaluation of four azadirachtin rich fractions from neem, azadirachta indica a. juss (family: meliaceae) as mosquito larvicides. | 1988 | 2908329 | |
| effect of azadirachta indica on plasmodium berghei berghei in mice. | azadirachta indica leaf extract has been investigated for antimalarial activity against drug sensitive strain of p. berghei berghei in mice. on administering the extract subcutaneously to infected mice in the "4-day schizontocidal test' 41.2% suppression of parasitaemia was observed. a similar observation was made when the extract was injected for 3 days before the animals were infected with the parasites, 21.7% chemosuppression was obtained. when treatment commenced after the infection had alre ... | 1985 | 2994439 |
| folklore therapeutic indigenous plants in periodontal disorders in india (review, experimental and clinical approach). | though a number of plants and their parts are used for dental ailments among population in rural and urban areas of developing countries, in india however, the most common house-hold, road-side plants are mango (mangifera indica), neem (azadirachta indica; melia azadirachta), ocimum (ocimum basilicum), tea-dust (camellia sinensis) and uncommonly murayya, i.e., currey leaf (murayya koenigi) [chopra et al. 1958, kirtikar and basu 1935, nadakarni 1954, satyavati 1984]. the leaves of these plants ar ... | 1988 | 3042642 |
| biochemical mechanism of the antimalarial activity of azadirachta indica leaf extract. | the antimalarial herb, azadirachta indica, acts by redox perturbation in the form of the imposition of substantial oxidant stress during malarial infection. the aqueous leaf extract substantially inhibited nadph cytochrome c(p-450) reductase activity in rats with a significant increase in the microsomal protein. the aniline hydroxylase activity and the phenobarbitone metabolism were also enhanced. the flavonoids quercetin-3-rhamnoside and quercetin-3-rutinoside (rutin) were isolated as the major ... | 1986 | 3081917 |
| in vitro antibacterial activity of neem oil. | 1986 | 3102364 | |
| mechanism of antifertility action of neem oil. | the purpose of this study was to determine whether the antifertility effect of the antiestrogenic substance neem oil, extracted from the seeds of azadirachta indica, acts directly on the uterus or through absorption from the vaginal epithelium into the general circulation. in 4 groups of rats the left uterine horn was ligated 2 days after coitus. rats in group a were used as controls. in group b 25 mcl neem oil was administered intravaginally on days 2-4 with the animals in head down position ... | 1988 | 3225018 |
| immunomodulatory activity of an aqueous extract of azadirachta indica stem bark. | the interference of an aqueous extract of the stem bark of azadirachta indica with different parts of the human immune system was investigated. the extract showed strong anticomplementary effects which were dose-and time-dependent and most pronounced in the classical complement pathway assay. moreover, a dose-dependent decrease in the chemiluminescence of polymorphonuclear leukocytes was observed and a dose-dependent increase in the production of migration inhibition factor by lymphocytes. | 1987 | 3302545 |
| mutagenicity tests of cashewnut shell liquid, rice-bran oil and other vegetable oils using the salmonella typhimurium/microsome system. | in view of the shortage of edible oils in india, nutritional and toxicological evaluations have been carried out on some unconventional oils to determine whether they might be safe for human consumption. as part of these evaluations, eight unconventional oils were tested by the ames mutagenicity assay, using salmonella typhimurium strains ta98 and ta100 with and without metabolic activation with s-9 mix prepared from the livers of rats pretreated with sodium phenobarbitone or aroclor 1254. of th ... | 1987 | 3315902 |
| in vitro antimalarial activity of neem (azadirachta indica a. juss) leaf and seed extracts. | 1987 | 3330711 | |
| [experimental study of the effect of raw materials of the neem tree and neem extracts on dermatophytes, yeasts and molds]. | in traditional indian medicine, various parts of the neem tree have been used for centuries, especially with skin diseases. these products are often applied in human mycoses. we tested some dried neem materials, neem oils as well as simple neem preparations and extracts with regard to their effect on 14 of the most common pathogenic fungi. neither the dried neem materials nor the medical preparations and oils had any effect on fungal growth; most of them were even contaminated with molds. some o ... | 1988 | 3407264 |
| acute toxicity study of the oil from azadirachta indica seed (neem oil). | the seed oil of azadirachta indica (neem oil) is well known for its medicinal properties in the indigenous indian system of medicine. its acute toxicity was documented in rats and rabbits by the oral route. dose-related pharmacotoxic symptoms were noted along with a number of biochemical and histopathological indices of toxicity. the 24-h ld50 was established as 14 ml/kg in rats and 24 ml/kg in rabbits. prior to death, animals of both species exhibited comparable pharmacotoxic symptoms in order ... | 1988 | 3419203 |
| non-hormonal post-coital contraceptive action of neem oil in rats. | neem oil, a natural product of azadirachta indica was investigated for various hormonal properties in relation to its post-coital contraceptive action. at subcutaneous doses up to 0.3 ml/rat, neem oil did not possess any estrogenic, anti-estrogenic or progestational activity and appeared not to interfere with the action of progesterone. these findings were confirmed using the histo-architecture of the uterus of treated rats. since the post-coital contraceptive effect of neem oil seems to be non- ... | 1988 | 3419204 |
| screening azadirachta indica and pisum sativum for possible antimalarial activities. | solvent-free extracts obtained from the leaves of azadirachta indica and pisum sativum were screened for antimalarial action using plasmodium berghei in mice. four days of oral dosing with 500 mg/kg and 125 mg/kg of the methanol extract of a. indica showed a parasite suppression which was statistically significant although all test animals died after 5 days, just 1 day longer than the untreated control group. a 50 mg/kg oral dose of the aqueous extract of p. sativum was found to have significant ... | 1986 | 3531729 |
| inhibition of mitochondrial functions by margosa oil: possible implications in the pathogenesis of reye's syndrome. | margosa oil (mo), a fatty acid-rich extract of the seeds of the neem tree and a reported cause of reye's syndrome, has been used in the induction of an experimental model of reye's syndrome in rats. it has been reported that mo causes a decrease in in vivo mitochondrial enzyme activity similar to that seen in reye's syndrome. we have attempted to uncover some of the biochemical mechanisms of mo's toxicity by examining its effect in vitro on isolated rat liver mitochondria. male rat liver mitocho ... | 1987 | 3658544 |
| antifertility effect of neem oil in female albino rats by the intravaginal & oral routes. | 1986 | 3699874 | |
| ventricular fibrillation and cardiac arrest due to neem leaf poisoning. | 1986 | 3759898 | |
| effect of neem seed oil on the blood glucose concentration of normal and alloxan diabetic rats. | 1986 | 3762197 | |
| assessment of oestrogenecity of neem leaf extract in rats. | 1986 | 3818029 | |
| the toxicity of azadirachta indica leaves in goats and guinea pigs. | the effects produced by the administration of aqueous suspensions of the green or dried leaves of azadirachta indica, a common tropical plant, were investigated in goats and guinea pigs. at doses of 50 or 200 mg/kg given orally over a period of up to eight weeks, the plant produced a progressive decrease in body weight, weakness, inappetence, and loss of condition. there were also decreases in heart, pulse and respiratory rates. diarrhea was observed in animals given the fresh leaves. in goats, ... | 1987 | 3824869 |
| neem leaf poisoning. | 2013 | 3837008 | |
| nimbolide, a constituent of azadirachta indica, inhibits plasmodium falciparum in culture. | the terpenoid lactone nimbolide, the structure of which has been unambiguously established, was found to inhibit plasmodium falciparum in culture with a moderate potency. the ec50 against the parasite line k1 from thailand was approximately 2.0 microm (0.95 microgram/ml). the ec50 of crude aqueous extract of azadirachta indica var. siamensis (sadao tree), was 115 micrograms/ml, and of crude ethanol extract was 5.0 micrograms/ml. since nimbolide is a major constituent in these extracts, it could ... | 1985 | 3895455 |
| investigation of an animal model of a reye-like syndrome caused by margosa oil. | following reports of a reye-like syndrome in children resulting from margosa oil (mo) ingestion, we administered mo to laboratory rats in an attempt to produce an animal model of reye's syndrome. male rats were injected intraperitoneally with either mo or corn oil and observed for clinical signs of a toxic response. after 15 h the animals were administered a second dose and the mo-treated animals developed florid neurological symptoms. the animals were then sacrificed and blood samples were anal ... | 1985 | 4080457 |
| proceedings: pharmacological studies on the leaves of azadirachta indica. | 1974 | 4156703 | |
| studies on plant gums: i--identification of nitrogenous compounds in neem (azadirachta indica) gum and isolation of d-glucosamine. | 1967 | 4233809 | |
| study of antiviral activity of tender leaves of margosa tree (melia azadericta) on vaccinia and variola virus: a preliminary report. | 1969 | 4309947 | |
| studies on plant gums. ii. separation of protein-rich and carbohydrate-rich components of neem (azadirachta indica) gum. | 1973 | 4792919 | |
| chemical compounds from azadirachta indica as inhibitors of potato virus x. | 1974 | 4829363 | |
| the proteinaceous, gum polysaccharide from azadirachta indica a. juss. | 1971 | 5152099 | |
| [influence of neem tree extracts on inflammatory changes of the gingiva]. | 1971 | 5292567 | |
| margosa oil poisoning as a cause of reye's syndrome. | vomiting, drowsiness, metabolic acidosis, polymorphonuclear leucocytosis, and encephalopathy developed in thirteen infants within hours of ingestion of margosa oil. liver biopsy of one infant and necropsy examination of icr strain mice after experimentally induced margosa-oil poisoning demonstrated pronounced fatty infiltration of the liver and proximal renal tubules as well as cerebral oedema. electron microscopy demonstrated mitochondrial damage. these findings indicate that margosa oil may be ... | 1981 | 6110100 |
| mutagenicity testing of two tropical plant materials with pesticidal potential in salmonella typhimurium: phytolacca dodecandra berries and oil from seeds of azadirachta indica. | in this study the mutagenic potential of two tropical plant materials was investigated in salmonella typhimurium strains ta98 and ta100. the oil extract from seeds of azadirachta indica showed no mutagenic activity in either strain with or without addition of metabolizing systems. when extracts of phytolacca dodecandra berries were tested, only the butanol extract caused direct mutagenicity in ta98. after addition of rat liver homogenate, again only the butanol extract was positive in ta98. addi ... | 1983 | 6352253 |
| the mutagenicities of seven coumarin derivatives and a furan derivative (nimbolide) isolated from three medicinal plants. | seven coumarin derivatives (imperatorin, heraclenin, xanthotoxin, marmesin, chelepin, oxypeucedanin, esculin) and a furan derivative (nimbolide) were screened on 6 ames tester strains (ta92, ta94, ta97, ta98, ta100, ta102). the eight compounds are chemicals isolated from three nigerian medicinal plants: afraegle paniculata, clausena anisata, and azadirachta indica. different preparations of the former are taken by nigerians for gut disturbances, and a concoction of the latter called "agbo" is ta ... | 1984 | 6387161 |
| ventricular fibrillation and cardiac arrest due to neem leaf poisoning. | 1984 | 6501205 | |
| anti-implantation effect of neem oil. | 1984 | 6532974 | |
| neem oil as a vaginal contraceptive. | 1984 | 6724648 | |
| anti-inflammatory and antipyretic activities of azadirachta indica. | 1981 | 6972048 | |
| reye-like syndrome due to margosa oil poisoning: report of a case with postmortem findings. | 1982 | 7081175 | |
| neem oil poisoning. | 2004 | 7141505 | |
| male antifertility activity of azadirachta indica in mice. | 1980 | 7205685 | |
| studies on plant gums: part viii--isolation & characterization of a high molecular weight glycoprotein from neem (azadirachta indica) gum. | 1981 | 7309097 | |
| margosa oil poisoning in india and malaysia. | 1981 | 7330956 | |
| isolation and characterization of two ige-reactive proteins from azadirachta indica pollen. | two allergenically active components present in the azadirachta indica whole pollen extract have been isolated by sequential ammonium sulfate precipitation (0-90%), deae-sephadex a-50 ion-exchange chromatography followed by gel filtration through sephadex g-200. the allergenicity of fractionated materials has been tested by skin prick test and elisa inhibition which reveal that aiai and aiaivb are the major allergens. immunoblot confirms the ige-binding activity of the proteins. although both fr ... | 1994 | 7519303 |
| an examination of the potential "genotoxic" carcinogenicity of a biopesticide derived from the neem tree. | structural analyses of azadirachtin, a promising biopesticide recently introduced into the united states, indicates that this natural product has the potential for acting as a "genotoxic" carcinogen. in view of the fact that genotoxic carcinogens are regarded as presenting a potential carcinogenic risk to humans, the present finding suggests that the possible metabolism of azadirachtin to dna-reactive products be evaluated experimentally. | 1995 | 7588652 |
| repellent action of neem cream against mosquitoes. | neem cream was used as mosquito repellent to provide protection against aedes albopictus, ae. aegypti, culex quinquefasciatus, anopheles culicifacies and an. subpictus mosquitoes. the application of neem cream on exposed body parts @2.0 gm/person showed 78 (range 65-95), 89 (range 66-100) and 94.4 (range 66-100) per cent protection against aedes, culex and anopheles mosquitoes respectively. significant difference was observed between neem cream treated and untreated group of population for aedes ... | 1995 | 7589727 |
| control of mosquito breeding using wood scrapings treated with neem oil. | wood scrapings were given shape of a ball and soaked in 5, 10 and 20% neem (azadirachta indica) oil diluted in acetone. control of anopheles stephensi and aedes aegypti breeding in water storage overhead tanks (ohts) with the application of these balls was achieved for 45 days. two balls soaked in 5% neem oil produced the best results among other concentrations tested. | 1995 | 7589730 |
| neem oil inhibits two-cell embryo development and trophectoderm attachment and proliferation in vitro. | the in vitro effect of neem oil was studied on the development of mouse two-cell embryos and trophectodermal cell attachment and proliferation. | 1994 | 7606156 |
| mode of long-term antifertility effect of intrauterine neem treatment (iunt). | the mode of antifertility action of intrauterine neem treatment (iunt) was studied. the effect of iunt on ovarian functions and uterine responsiveness to ovarian hormones was examined in adult wistar rats. the treated animals had normal reproductive cycles as indicated by the vaginal smears; serum progesterone levels were also in the normal range. effect of exogenous estradiol following iunt in ovariectomized rats showed comparable uterine weight gain as in control group; decidual cell reaction ... | 1995 | 7621690 |
| larvicidal potential of five philippine plants against aedes aegypti (linnaeus) and culex quinquefasciatus (say). | five species of philippine plants, reported in the literature to have insecticidal properties, were selected for investigation, namely: anona squamosa ("atis" or sugar apple), eucalyptus globulus ("bagras" or olive gum eucalyptus), lansium domesticum ("lansones"), azadirachta indica ("neem") and codiaeum variegatum ("san francisco" or croton). these were screened and assayed for their larvicidal potential against aedes aedes aegypti (linnaeus) and culex quinquefasciatus (say) by exposing 3rd-4th ... | 1994 | 7667727 |
| aid groups back challenge to neem patents. | 1995 | 7675092 | |
| neem unsheaths contraceptive potential. | 1995 | 7675093 | |
| development of combined use of neem (azadirachta indica) and water management for the control of culicine mosquitoes in rice fields. | crude neem products have earlier shown considerable promise for control of culicine mosquito vectors in rice fields as a by-product of their agricultural use as fertilizers, but suffer from disadvantages of bulkiness and lack of stability in storage. relatively stable lipid-rich fractions of neem were shown to be as effective as good-quality crude neem products in control of breeding of culicine vectors of japanese encephalitis, and also produced a slight but significant reduction in populations ... | 1995 | 7696685 |
| field evaluation of mosquito repellent action of neem oil. | 1994 | 7713267 | |
| evaluation of neem oil as sandfly, phlebotomus papatasi (scopoli) repellent in an oriental sore endemic area in rajasthan. | 1994 | 7777937 | |
| antimalarial activity in vitro of cochlospermum tinctorium tubercle extracts. | resistance of plasmodium falciparum to current antimalarial compounds has drastically increased during the last few years and is now a major public health problem. we have studied plants traditionally used in africa against malaria. extracts of the tubercles of cochlospermum tinctorium a. rich, commonly used in burkina faso, were tested in vitro on 2 strains of p. falciparum, one (fcb1-colombia) chloroquine resistant and the other (f32-tanzania) chloroquine sensitive. extracts were obtained by i ... | 1995 | 7778154 |
| preliminary laboratory trial of neem on anopheles and culex larvae in zambia. | 1995 | 7788686 | |
| the effect of neemazal on aedes aegypti (diptera: culicidae). | the effect of neemazal (trifolio-m gmbh, lahnau), a neem seed kernel extract, on larvae of aedes aegypti was tested. second, third and fourth instar larvae were reared in water containing different concentrations of neemazal. mortality rates and the stage in which mortality occurred were recorded. the surviving larvae were left in the treated water until adult emergence and the number of eggs laid by the emerged females was recorded in order to evaluate possible fecundity-reducing effect of subl ... | 1994 | 7812312 |
| pharmacological effects of azadirachta indica (neem) leaf extract on the ecg and blood pressure of rat. | neem leaf alcoholic extract (nle) was investigated for its effects on the ecg and blood pressure of rat. intravenous administration of nle (100, 300 and 1000 mg/kg) resulted in initial bradycardia followed by cardiac arrhythmia in rats. nle produced a significant and dose-related fall in blood pressure which was immediate, sharp and persistent. pre-treatment with either atropine or mepyramine failed to prevent the hypotensive effect of nle. | 1994 | 7814089 |