Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [radioactive nuclides in the marine environment--distribution and behaviour of 95zr, 95nb originated from fallout]. | to investigate behaviour of 95zr, 95nb in the marine environment, various samples have been collected and measured by means of ge(li) gamma-ray spectrometry and/or radiochemical analysis during a period from 1974 to 1982 at coastal area of tokai-mura, ibaraki prefecture. concentration of the nuclides in seaweeds increased remarkably after atmospheric nuclear detonation by p.r. of china, and the activity ratio between the nuclides changed by time was not fit well by the transient decay equation. ... | 1984 | 6505297 |
| inhibition of hiv-1 reverse transcriptase and protease by phlorotannins from the brown alga ecklonia cava. | the bioassay-directed isolation of a marine brown alga, ecklonia cava, afforded four phlorotannin derivatives, eckol (1), 8,8'-bieckol (2), 8,4"'-dieckol (3), and phlorofucofuroeckol a (4). among these compounds, 2 and 3 exhibited an inhibitory effect on human immunodeficiency virus type 1 (hiv-1) reverse transcriptase (rt) and protease. specifically, they inhibited the rt more potently than the protease. the inhibitory activity of compound 2 (ic(50), 0.51 microm) against hiv-1 rt was comparable ... | 2004 | 15056863 |
| triphlorethol-a from ecklonia cava protects v79-4 lung fibroblast against hydrogen peroxide induced cell damage. | in the present study, triphlorethol-a, a phlorotannin, was isolated from ecklonia cava and its antioxidant properties were investigated. triphlorethol-a was found to scavenge intracellular reactive oxygen species (ros) and 1,1-diphenyl-2-picrylhydrazyl (dpph) radical, and thus prevented lipid peroxidation. the radical scavenging activity of triphlorethol-a protected the chinese hamster lung fibroblast (v79-4) cells exposed to hydrogen peroxide (h2o2) against cell death, via the activation of erk ... | 2005 | 16036369 |
| improvement of memory by dieckol and phlorofucofuroeckol in ethanol-treated mice: possible involvement of the inhibition of acetylcholinesterase. | phlorotannins, the polyphonic compounds found in brown eisenia and ecklonia algae, have several pharmacologically beneficial effects such as anti-inflammation. in addition, our recent data show that these compounds may improve the cognitive functions of aged humans suggesting the potential ability to enhance memory in several neurodegenerative disorders. to examine the experimental hypothesis that two effective components of ecklonia cava, dieckol and phlorofucofuroeckol (pff), have memory-enhan ... | 2005 | 16042079 |
| cytoprotective effect of phloroglucinol on oxidative stress induced cell damage via catalase activation. | we investigated the cytoprotective effect of phloroglucinol, which was isolated from ecklonia cava (brown alga), against oxidative stress induced cell damage in chinese hamster lung fibroblast (v79-4) cells. phloroglucinol was found to scavenge 1,1-diphenyl-2-picrylhydrazyl (dpph) radical, hydrogen peroxide (h(2)o(2)), hydroxy radical, intracellular reactive oxygen species (ros), and thus prevented lipid peroxidation. as a result, phloroglucinol reduced h(2)o(2) induced apoptotic cells formation ... | 2006 | 16215988 |
| eckol isolated from ecklonia cava attenuates oxidative stress induced cell damage in lung fibroblast cells. | we have investigated the cytoprotective effect of eckol, which was isolated from ecklonia cava, against oxidative stress induced cell damage in chinese hamster lung fibroblast (v79-4) cells. eckol was found to scavenge 1,1-diphenyl-2-picrylhydrazyl radical, hydrogen peroxide (h(2)o(2)), hydroxy radical, intracellular reactive oxygen species (ros), and thus prevented lipid peroxidation. as a result, eckol reduced h(2)o(2) induced cell death in v79-4 cells. in addition, eckol inhibited cell damage ... | 2005 | 16253238 |
| antiproliferative and antioxidant properties of an enzymatic hydrolysate from brown alga, ecklonia cava. | the potential antiproliferative and antiradical activities of an enzymatic extract of ecklonia cava together with its crude polysaccharide (cpof) and crude polyphenolic fractions (cphf) were evaluated in vitro. tested extracts showed strong selective cell proliferation inhibition on all cancer cell lines tested, especially cphf extract, containing high polyphenol amount, showed 5.1 microg/ml of ic(50) value on murine colon cancer (ct-26) cell line. according to the nuclear staining experiment, a ... | 2006 | 16516367 |
| an antioxidative and antiinflammatory agent for potential treatment of osteoarthritis from ecklonia cava. | osteoarthritis is thought to be induced by the ageing-related loss of homeostatic balance between degeneration and repair mechanism around cartilage tissue in which inflammatory mediators such as reactive oxygen species, cytokines and prostaglandins are prone to over-production under undesirable physiological conditions. phlorotannins are unique polyphenolic compounds bearing dibenzo-1,4-dioxin skeleton which are not found in terrestrial plants but found only in some brown algal species such as ... | 2006 | 16526282 |
| protective effect of triphlorethol-a from ecklonia cava against ionizing radiation in vitro. | we studied the cytoprotective effect of triphlorethol-a against gamma-ray radiation-induced oxidative stress. in this study, hydrogen peroxide, which is a reactive oxygen species (ros), was detected using 2',7'-dichlorodihydrofluorescein diacetate (dcf-da) assay. triphlorethol-a reduced intracellular hydrogen peroxide generated by gamma-ray radiation. this compound provided protection against radiation-induced membrane lipid peroxidation and cellular dna damage which are the main targets of radi ... | 2006 | 16571919 |
| phlorotannins in ecklonia cava extract inhibit matrix metalloproteinase activity. | matrix metalloproteinase (mmp) inhibitors have been identified as potential therapeutic candidates for metastasis, arthritis, chronic inflammation and wrinkle formation. for the first time here we report a detailed study on the inhibitory effects of phlorotannins in brown algae, ecklonia cava (ec) on mmp activities in cultured human cell lines. a novel gelatin digestion assay could visualize complete inhibition of bacterial collagenase-1 activity at 20 microg/ml of ec extract during preliminary ... | 2006 | 16737716 |
| the inhibitory effects of eckol and dieckol from ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts. | in order to develop new anti-photoaging agents, we examined the inhibitory effects of 29 seaweed extracts on transcriptional activities of nf-kappab and ap-1, and mmp-1 expression. the extracts from 3 species of alariaceae, eisenia bicyclis, ecklonia cava and ecklonia stolonifera, have showed strong inhibition of both nf-kappab and ap-1 reporter activity, which were well correlated with their abilities to inhibit mmp-1 expression. in addition, mmp-1 expression was dramatically attenuated by trea ... | 2006 | 16880634 |
| triphlorethol-a induces heme oxygenase-1 via activation of erk and nf-e2 related factor 2 transcription factor. | triphlorethol-a, phlorotannin found in ecklonia cava, induced heme oxygenase-1 (ho-1) expression at mrna and protein levels, leading to increased ho-1 activity. transcription factor nf-e2 related factor 2 (nrf2) regulates antioxidant response element (are) of phase 2 detoxifying and antioxidant enzymes. triphlorethol-a increased nuclear translocation, are binding, and transcriptional activity of nrf2. triphlorethol-a exhibited activation of erk and u0126, inhibitor of erk kinase, suppressed trip ... | 2007 | 17467702 |
| antioxidant and antiinflammatory activities of ventol, a phlorotannin-rich natural agent derived from ecklonia cava, and its effect on proteoglycan degradation in cartilage explant culture. | osteoarthritis is thought to be induced by the aging-related loss of homeostatic balance between degeneration and repair mechanism around cartilage tissue in which inflammatory mediators such as reactive oxygen species, cytokines and prostaglandins are prone to overproduction under undesirable physiological conditions. phlorotannins are unique polyphenolic compounds bearing dibenzo-1,4-dioxin skeleton which are not found in terrestrial plants but found only in some brown algal species such as ec ... | 2004 | 17564307 |
| effects of ecklonia cava ethanolic extracts on airway hyperresponsiveness and inflammation in a murine asthma model: role of suppressor of cytokine signaling. | ecklonia cava (ec) is a brown alga that evidences radical scavenging activity, bactericidal activity, tyrosinase inhibitory activity, and protease inhibitory activity. however, its anti-allergic effects remain poorly understood. in the current study, we attempted to determine whether pretreatment with ec induces a significant inhibition of asthmatic reactions in a mouse asthma model. mice sensitized and challenged with ovalbumin (ova) evidenced typical asthmatic reactions, as follows: an increas ... | 2008 | 17804193 |
| biofouling attractants from a brown marine alga ecklonia cava. | in recent years, industrial pollutants and the mountain forest fire ashes released into seawater cause damage to the marine environment, mainly it reduces the algal productivity in the inter tidal region. to get recover from the stress due to pollutants and to increase the growth and development of biofouling algae (benthic organisms), ecklonia cava extract was investigated for its biofouling attracting efficiency. bioactive guided fractions of e. cava extract derived from column chromatography ... | 2007 | 17915745 |
| immunomodulatory effects of an enzymatic extract from ecklonia cava on murine splenocytes. | we investigated whether the brown seaweed alariaceae ecklonia cava (e. cava) has immunological effects on splenocytes in vitro. for that purpose, we prepared an enzymatic extract from e. cava (eck) by using the protease, kojizyme. here, eck administered to icr mice dramatically enhanced the proliferation of their splenocytes and increased the number of their lymphocytes, monocytes and granulocytes. in flow cytometry assays performed to identify in detail the specific phenotypes of these prolifer ... | 2008 | 18172723 |
| radioprotective properties of eckol against ionizing radiation in mice. | we have investigated the radioprotective efficacy of eckol, a component of brown seaweed ecklonia cava, against the gamma ray-induced damage in vivo. our results showed that eckol significantly decreased the mortality of lethally irradiated mice. the mechanisms of eckol's protection were found to include: an improvement in hematopoietic recovery, the repair of damaged dna in immune cells and an enhancement of their proliferation, which had been severely suppressed by ionizing radiation. thus, we ... | 2008 | 18294966 |
| modulation of apoptosis of eckol against ionizing radiation in mice. | to investigate the radioprotective potential of eckol, a component of the seaweed ecklonia cava, against radiation in vivo, we evaluated the effect of eckol on cyto- and histo-protective capability of the lymphocytes and intestine against damage induced by a single whole body irradiation (wbi) in vivo. here, we ascertained that eckol protected the lymphocytes' viability and rescued intestinal cells from radiation-induced apoptosis by decreasing the amount of pro-apoptotic p53 and bax and increas ... | 2008 | 18522802 |
| inhibitory effects of triphlorethol-a on mmp-1 induced by oxidative stress in human keratinocytes via erk and ap-1 inhibition. | oxidative stress is known to generate reactive oxygen species (ros) in cells, which subsequently induce the synthesis of matrix metalloproteinases (mmp) and an aging phenomenon. the protective effects of triphlorethol-a, derived from ecklonia cava, were investigated against hydrogen peroxide (h(2)o(2))-induced damage using human skin keratinocytes. data showed that triphlorethol-a inhibited ros formation, induced catalase expression, inhibited dna damage, and increased cell viability in keratino ... | 2008 | 18569608 |
| anti-hiv-1 activity of phloroglucinol derivative, 6,6'-bieckol, from ecklonia cava. | ecklonia cava (ec), which is an edible marine brown alga with a broad range of bioactivities, belongs to the family of laminariaceae. the bioactive 6,6'-bieckol, one of the main phloroglucinol derivatives naturally occurred from this genus, was isolated and characterized by nmr techniques. for the first time, human immunodeficiency virus type-1 (hiv-1) inhibitory activity of 6,6'-bieckol showed wild inhibition against hiv-1 induced syncytia formation (ec(50) 1.72 microm), lytic effects (ec(50) 1 ... | 2008 | 18693022 |
| ecklonia cava ethanolic extracts inhibit lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in bv2 microglia via the map kinase and nf-kappab pathways. | ecklonia cava (ec) is a brown alga that has demonstrated radical scavenging, bactericidal, tyrosinase inhibitory, and protease inhibitory activities. however, the molecular mechanisms underlying its anti-inflammatory action remain unclear. in the current study, we attempted to determine whether pretreatment with ec induces a significant inhibition of anti-inflammatory activity in lipopolysaccharide (lps)-stimulated murine bv2 microglia. our results indicate that ec inhibits lps-induced nitric ox ... | 2009 | 19111593 |
| ecklonia cava extract suppresses the high-affinity ige receptor, fcepsilonri expression. | basophils and mast cells express fcepsilonri, a high-affinity receptor for ige, on the cell surface and act as effector cells in allergic reactions. in this study, we investigated the inhibitory effect of ecklonia cava (ec) methanolic extract on the expression of fcepsilonri in human basophilic ku812f cells. flow cytometric analysis revealed that ec extract caused a concentration-dependent reduction in the cell surface expression of fcepsilonri. the extract was also capable of reducing the bindi ... | 2009 | 19138721 |
| chemical components and its antioxidant properties in vitro: an edible marine brown alga, ecklonia cava. | seven phlorotannins were isolated and characterized from an edible marine brown alga ecklonia cava (ec), along with three common sterol derivatives (fucosterol, ergosterol, and cholesterol) according to the comprehensive spectral analysis of ms and nmr data. compounds 5 (7-phloro eckol) and 7 (6,6'-bieckoll) of phlorotannin derivatives were obtained for the first time with the high yields. no reports of compound 3 (fucodiphloroethol g) was published up to date. the antioxidant properties of all ... | 2009 | 19201199 |
| differentiation of human osteosarcoma cells by isolated phlorotannins is subtly linked to cox-2, inos, mmps, and mapk signaling: implication for chronic articular disease. | arthritis is one of the most prevalent chronic inflammatory diseases, and it is characterized by structural and biochemical changes in major tissues of the joint, including degradation of the cartilage matrix, insufficient synthesis of extracellular matrix (ecm). ecklonia cava (ec) is a member of the family of laminariaceae, which is an edible marine brown alga with various bioactivities. in this study of the methanol extract of brown alga ec, the dieckol (1) and 1-(3',5'-dihydroxyphenoxy)-7-(2' ... | 2009 | 19330880 |
| inhibitory effect of phlorotannins isolated from ecklonia cava on mushroom tyrosinase activity and melanin formation in mouse b16f10 melanoma cells. | in this study, to assess the feasibility of phlorotannins isolated from ecklonia cava as an inhibitor of melanin formation, we evaluated its inhibitory effects on mushroom tyrosinase and 3-isobutyl-1-methylxanthine (ibmx)-induced melanin formation inhibitory effects in b16f10 melanoma cell. the ethanolic (etoh) extract and ethyl acetate (etoac) soluble fraction obtained from e. cava evidenced a marked inhibitory effect on mushroom tyrosinase at a concentration of 50 μg/ml. repeated column chroma ... | 2009 | 19361156 |
| induction of apoptosis by phloroglucinol derivative from ecklonia cava in mcf-7 human breast cancer cells. | phloroglucinol derivatives, dioxinodehydroeckol (1) and 1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin (2), were isolated from ecklonia cava. their ability to inhibit the proliferation of human breast cancer cells were evaluated by measuring cell death via induction of apoptosis. compound 1 exerted a higher anti-proliferative activity in human breast cancer cells compared with compound 2. furthermore, compound 1 induced a significant proliferative i ... | 2009 | 19393283 |
| inhibitory effects and molecular mechanism of dieckol isolated from marine brown alga on cox-2 and inos in microglial cells. | to identify the neuroprotective effect of dieckol, a hexameric compound of phloroglucinol isolated from marine brown alga, ecklonia cava , this study investigated the anti-inflammatory effect of dieckol on lipopolysaccharide (lps)-stimulated murine bv2 microglia and elucidated the molecular mechanism. the results showed that dieckol suppresses lps-induced production of nitric oxide (no) and prostaglandin e(2) (pge(2)) and expression of inducible nitric oxide synthase (inos) and cyclooxygenase-2 ... | 2009 | 19408937 |
| effect of phlorotannins isolated from ecklonia cava on melanogenesis and their protective effect against photo-oxidative stress induced by uv-b radiation. | in the present study, three kinds of phlorotannins, marine algal polyphenol, were isolated from a brown alga ecklonia cava, and their inhibitory effect on melanogenesis as well as the protective effect against photo-oxidative stress induced by uv-b radiation was investigated. the effect on melanogenesis was evaluated via the inhibitory effects of tyrosinase and melanin synthesis. among the phlorotannins, dieckol showed higher effect than that of the other phlorotannins in the both assays; especi ... | 2009 | 19490939 |
| 1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin inhibits adipocyte differentiation of 3t3-l1 fibroblasts. | in this study, we isolated the phloroglucinol derivative, 1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin (1), from ecklonia cava and evaluated its potential inhibition on adipocyte differentiation in 3t3-l1 cells. lipid accumulation along with the expression of several genes associated with adipogenesis and lipolysis was examined at the end of differentiation. lipid accumulation level was examined by measuring triglyceride content and oil-red o stai ... | 2010 | 19680725 |
| protective effects of dieckol isolated from ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells. | the effect of dieckol, one of phlorotannin polyphenol compound purified from ecklonia cava (e. cava) against high glucose-induced oxidative stress was investigated using human umbilical vein endothelial cells (huvecs), which is susceptible to oxidative stress. high glucose (30mm) treatment induced huvecs cell death, but dieckol, at concentration 10 or 50microg/ml, significantly inhibited the high glucose-induced cytotoxicity. furthermore, treatment with dieckol dose-dependently decreased thiobar ... | 2010 | 19896528 |
| brown alga ecklonia cava attenuates type 1 diabetes by activating ampk and akt signaling pathways. | the antidiabetic therapeutic effect of ecklonia cava, a brown alga, was investigated using streptozotocin-induced type 1 diabetes mellitus rats and c2c12 myoblasts. the methanol extract of e. cava (ecm), having a strong radical scavenging activity, significantly reduced plasma glucose level and increased insulin concentration in type 1 diabetes mellitus rats. moreover, the elevation of plasma alt in diabetic rats was dramatically restored near to normal range by the treatment of ecm, whereas ast ... | 2010 | 19913068 |
| up-regulation of nrf2-mediated heme oxygenase-1 expression by eckol, a phlorotannin compound, through activation of erk and pi3k/akt. | the aim of the present study was to examine the cytoprotective effect of eckol, a phlorotannin found in ecklonia cava and to elucidate underlying mechanisms. heme oxygenase-1 (ho-1) is an important antioxidant enzyme that plays a role in cytoprotection against oxidative stress. eckol-induced ho-1 expression both at the level of mrna and protein in chinese hamster lung fibroblast (v79-4) cells, resulting in increased ho-1 activity. the transcription factor nf-e2-related factor 2 (nrf2) is a criti ... | 2010 | 19931411 |
| antibacterial activity of ecklonia cava against methicillin-resistant staphylococcus aureus and salmonella spp. | ecklonia cava is a brown alga (laminariales, phaeophyta) growing on the subtidal rocky shores of korea. it has antioxidant, antidiarrhea, and anticoagulant effects. in this study, the antimicrobial activity of e. cava etoh extract and its fractions (n-hexane, ch2cl2, etoac, n-buoh, and h2o) were investigated against methicillin-resistant staphylococcus aureus and salmonella spp. the e. cava etoac fraction showed good antibacterial activity against all bacteria. eckol isolated from e. cava etoac ... | 2010 | 20001325 |
| inhibition of the expression on mmp-2, 9 and morphological changes via human fibrosarcoma cell line by 6,6'-bieckol from marine alga ecklonia cava. | matrix metalloproteinases (mmps) are a family of zinc-endopeptidases which can degrade extracellular matrix (ecm) components and play important roles in a variety of biological and pathological processes. 6,6'-bieckol isolated and characterized from an edible marine brown alga ecklonia cava (ec), according to the comprehensive spectral analysis of ms and nmr data. here the influence of 6,6'-bieckol on expressions of mmps was examined by zymography and western blot analysis via human fibrosarcoma ... | 2010 | 20132738 |
| phloroglucinol (1,3,5-trihydroxybenzene) protects against ionizing radiation-induced cell damage through inhibition of oxidative stress in vitro and in vivo. | exposure of cells to gamma-rays induces the production of reactive oxygen species (ros) that play a main role in ionizing radiation damage. we have investigated the radioprotective effect of phloroglucinol (1,3,5-trihydroxybenzene), phlorotannin compound isolated from ecklonia cava, against gamma-ray radiation-induced oxidative damage in vitro and in vivo. phloroglucinol significantly decreased the level of radiation-induced intracellular ros and damage to cellular components such as the lipid, ... | 2010 | 20188716 |
| effect of supplementation with ecklonia cava polyphenol on endurance performance of college students. | ecklonia cava polyphenol (ecp) is a potent antioxidant and procirculatory agent that may contribute to improvement of endurance performance during highly intense exercise. this study evaluated the acute effect of an ecp-supplemented drink against a placebo on maximum endurance capacity and related physiological parameters. twenty men 18-23 yr old volunteered as participants. each performed 2 randomized trials with a 1-week interval between them. one trial was with ecp and the other with a placeb ... | 2010 | 20190354 |
| protective effects of enzymatic digest from ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells. | antioxidants can prevent pathological damage caused by hyperglycaemia-induced oxidative stress associated with diabetes. in the present study, we investigated whether the brown alga ecklonia cava has protective effects against high glucose-induced oxidative stress in human umbilical vein endothelial cells (huvecs). for that purpose, we prepared an enzymatic digest from e. cava (ecc) by using the carbohydrate, celluclast. | 2010 | 20355053 |
| ecklonia cava extracts inhibit lipopolysaccharide induced inflammatory responses in human endothelial cells. | ecklonia cava (ec) is a brown alga that evidences radical scavenging, bactericidal, tyrosinase inhibitory and protease inhibitory activities. however, the antiinflammatory effects in human endothelial cells and its molecular mechanism remain poorly understood. in this study, we attempted to determine whether pretreatment with ec extracts induce a significant inhibition of antiinflammatory activities in lipopolysaccharide (lps) induced human endothelial cells. we found that each ec extract inhibi ... | 2010 | 20363280 |
| anti-adipogenic effect of dioxinodehydroeckol via ampk activation in 3t3-l1 adipocytes. | dioxinodehydroeckol (dhe) isolated from ecklonia cava, has previously been investigated for its inhibition of the differentiation of 3t3-l1 preadipocytes into adipocytes. levels of lipid accumulation were measured, along with changes in the expression of genes and proteins associated with adipogenesis and lipolysis. confluent 3t3-l1 preadipocytes in medium with or without different concentrations of dhe for 7 days were differentiated into adipocytes. lipid accumulation was quantified by measurin ... | 2010 | 20385110 |
| enzymatic extract from ecklonia cava induces the activation of lymphocytes by il-2 production through the classical nf-κb pathway. | activated nuclear factor-kappa b (nf-κb), a well-known transcription factor, leads to the development, differentiation, and proliferation of t and b lymphocytes and the secretion of cytokines by the classical pathway. we have examined here whether an enzymatic extract (eck) from the brown seaweed, alariaceae laminariales ecklonia cava may contribute to activating lymphocytes through the nf-κb pathway for participation in immune responses. in our study, eck dose-dependently enhanced the prolifera ... | 2011 | 20480199 |
| dieckol isolated from ecklonia cava inhibits alpha-glucosidase and alpha-amylase in vitro and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice. | this study was designed to investigate whether dieckol may inhibit α-glucosidase and alpha-amylase activities, and alleviate postprandial hyperglycemia in streptozotocin-induced diabetic mice. dieckol isolated from ecklonia cava, brown algae, evidenced prominent inhibitory effect against alpha-glucosidase and alpha-amylase. the ic(50) values of dieckol against alpha-glucosidase and alpha-amylase were 0.24 and 0.66 mm, respectively, which evidenced the higher activities than that of acarbose. die ... | 2010 | 20600532 |
| phlorotannins from ecklonia cava (phaeophyceae): biological activities and potential health benefits. | the importance of bioactive derivatives as functional ingredients has been well recognized due to their valuable health beneficial effects. therefore, isolation and characterization of novel functional ingredients with biological activities from seaweeds have gained much attention. ecklonia cava kjellman is an edible seaweed, which has been recognized as a rich source of bioactive derivatives mainly, phlorotannins. these phlorotannins exhibit various beneficial biological activities such as anti ... | 2010 | 20803523 |
| dieckol rescues mice from lethal irradiation by accelerating hemopoiesis and curtailing immunosuppression. | to evaluate the radioprotective effect of dieckol, a component of the brown algae ecklonia cava. | 2010 | 20883140 |
| cytoprotective effects of triphlorethol-a against formaldehyde-induced oxidative damage and apoptosis: role of mitochondria-mediated caspase-dependent pathway. | the toxicity of formaldehyde (hcho) has been attributed to its ability to form adducts with dna and proteins. triphlorethol-a, derived from ecklonia cava, was reported to exert a cytoprotective effect against oxidative stress damage via an antioxidant mechanism. the aim of this study was to examine the mechanisms underlying the triphlorethol-a ability to protect chinese hamster lung fibroblast (v79-4) cells against hcho-induced damage. triphlorethol-a significantly decreased the hcho-induced int ... | 2010 | 20954074 |
| screening of marine algae for potential tyrosinase inhibitor: those inhibitors reduced tyrosinase activity and melanin synthesis in zebrafish. | in order to find new anti-browning and whitening agents in this study, we investigated 43 indigenous marine algae for tyrosinase inhibitory activity. the extracts from endarachne binghamiae, schizymenia dubyi, ecklonia cava (ec) and sargassum silquastrum (ss) evidenced potent tyrosinase inhibitory activity similar to that of positive control, kojic acid. among those marine algae, ec and ss are distributed abundantly on jeju island. therefore, we selected those two species for further studies. ou ... | 2011 | 21544943 |
| effect of phlorotannins isolated from ecklonia cava on angiotensin i-converting enzyme (ace) inhibitory activity. | inhibition of angiotensin i-converting enzyme (ace) activity is the most common mechanism underlying the lowering of blood pressure. in the present study, five organic extracts of a marine brown seaweed ecklonia cava were prepared by using ethanol, ethyl acetate, chloroform, hexane, and diethyl ether as solvents, which were then tested for their potential ace inhibitory activities. ethanol extract showed the strongest ace inhibitory activity with an ic(50) value of 0.96 mg/ml. five kinds of phlo ... | 2011 | 21556221 |
| influenza virus neuraminidase inhibitory activity of phlorotannins from the edible brown alga ecklonia cava. | influenza a virus infections continue to pose a major threat to humans and several animal species. neuraminidase (na) is one of the most promising targets for the development of drugs against influenza viruses because of its critical role in the viral life cycle. during the course of a search for na inhibitors from edible natural sources, we found that the ethyl acetate layer of ethanol extracts of ecklonia cava showed extremely high na-inhibitory activity (72.1% inhibition at 30 μg/ml). bioacti ... | 2011 | 21585204 |
| phloroglucinol (pg) purified from ecklonia cava attenuates radiation-induced apoptosis in blood lymphocytes and splenocytes. | phloroglucinol (pg), a polyphenol compound of eckloniacava known as brown algae abundant in jeju island, has been proposed to exert the antioxidative and cytoprotective effects against oxidative stress. in this study, we confirmed that pg protected mice from damages caused by ionizing radiation and investigated its protection mechanism in detail. the result showed that pg increased the viability of splenocytes without cytotoxicity. also, pg significantly enhanced the proliferation of splenocytes ... | 2011 | 21693160 |
| butanol extract of ecklonia cava prevents production and aggregation of beta-amyloid, and reduces beta-amyloid mediated neuronal death. | beta-amyloid (aβ) is a major pathogenic peptide for alzheimer's disease (ad) and is generated by the processing of amyloid precursor protein (app). the aβ monomers aggregate into oligomeric and fibrillar forms which have been implicated as the toxic species inducing the neuronal dysfunction. brown algae ecklonia cava is known for its anti-oxidant and anti-inflammatory functions. therefore, we tested the effect of e. cava extract on the production and aggregation of aβ peptides. the butanol extra ... | 2011 | 21693162 |
| effects of 12-week oral supplementation of ecklonia cava polyphenols on anthropometric and blood lipid parameters in overweight korean individuals: a double-blind randomized clinical trial. | the effects of 12-week supplementation with a polyphenol extract from ecklonia cava (ecp) on anthropometry, serum biochemistry and hematology have been investigated. ninety-seven overweight male and female adults (average age 40.5 ± 9.2 yr and body mass index (bmi) of 26.5 ± 1.6 kg/m²) were enrolled in a randomized, double-blind, placebo-controlled trial with parallel-group design. subjects were randomly allocated into three groups designated as pc (placebo), ld (low-dose, 72 mg-ecp/day) and hd ... | 2012 | 21717516 |
| dieckol from ecklonia cava regulates invasion of human fibrosarcoma cells and modulates mmp-2 and mmp-9 expression via nf-+¦b pathway. | the matrix metalloproteinase (mmp) family is involved in the breakdown of extracellular matrix in normal physiological processes, as well as in the disease processes such as arthritis and cancer metastasis. in the present study, dieckol was obtained with high yield from marine brown alga ecklonia cava (ec), and its effect was assessed on the expression of mmp-2 and -9 and morphological changes in human fibrosarcoma cell line (ht1080). dieckol inhibited the expression of mmp-2 and -9 in a dose-de ... | 2011 | 21826183 |
| exploiting biological activities of brown seaweed ecklonia cava for potential industrial applications: a review. | seaweeds are rich in vitamins, minerals, dietary fibres, proteins, polysaccharides and various functional polyphenols. many researchers have focused on brown algae as a potential source of bioactive materials in the past few decades. ecklonia cava is a brown seaweed that is abundant in the subtidal regions of jeju island in the republic of korea. this seaweed attracted extensive interest due to its multiple biological activities. e. cava has been identified as a potential producer of wide spectr ... | 2012 | 21942760 |
| potential pharmacological applications of polyphenolic derivatives from marine brown algae. | recently, the isolation and characterization of the biologically active components from seaweeds have gained much attention from various research groups across the world. the marine algae have been studied for biologically active components and phlorotannins are one among them. among marine algae, brown algal species such as ecklonia cava, eisenia arborea, ecklonia stolinifera and eisenia bicyclis have been studied for their potential biological activities. majority of the investigations on phlo ... | 2011 | 22004951 |
| protective effects of phlorotannins against ultraviolet b radiation in zebrafish (danio rerio). | exposure to ultraviolet b (uv-b) radiation has been associated with a variety of adverse effects in all forms of life, including micro-organisms, plants, animals and humans. ultraviolet b induces cell damage at the molecular level and consequently organisms must employ strategies to protect themselves from sunlight and to repair uv-b-induced cellular damage. in this study, the uv-b protective effects of four different phlorotannins isolated from a brown alga (ecklonia cava) were determined using ... | 2012 | 22040269 |
| Molecular docking studies of a phlorotannin, dieckol isolated from Ecklonia cava with tyrosinase inhibitory activity. | In this study, the phlorotannin dieckol, which was isolated from the brown alga Ecklonia cava, was examined for its inhibitory effects on melanin synthesis. Tyrosinase inhibitors are important agents for cosmetic products. We therefore examined the inhibitory effects of dieckol on mushroom tyrosinase and melanin synthesis, and analyzed its binding modes using the crystal structure of Bacillus megaterium tyrosinase (PDB ID: 3NM8). Dieckol inhibited mushroom tyrosinase with an IC(50) of 20µM and w ... | 2012 | 22112542 |
| a polysaccharide isolated from ecklonia cava fermented by lactobacillus brevis inhibits the inflammatory response by suppressing the activation of nuclear factor-κb in lipopolysaccharide-induced raw 264.7 macrophages. | we previously reported that the increment of carbohydrate content in the viscozyme(®) l (novozyme corp., oklahoma city, ok, usa) extract of lactobacillus brevis-fermented ecklonia cava affected the inhibition of nitric oxide (no) production and that it might be related to the polysaccharide compound. however, there is no report of anti-inflammatory effects of the polysaccharide or its biological mechanism. here, we investigated the anti-inflammatory effects of the polysaccharide and its biologic ... | 2011 | 22145773 |
| in vitro antibacterial and anti-inflammatory properties of seaweed extracts against acne inducing bacteria, propionibacterium acnes. | this study was conducted to evaluate the antimicrobial activities of common seaweeds from the coast of south korea against the etiologic agents of acne vulgaris. fifty-seven species of seaweed were screened for potential antimicrobial activity. methanol extracts of 13 species (22.8%) showed inhibitory effects against propionibacterium acnes. the aqueous extracts of only two species (3.5%) showed antimicrobial activity. when tested with the agar disk diffusion method, ecklonia cava, e. kurome, is ... | 2011 | 22167943 |
| effects of brown alga, ecklonia cava on glucose and lipid metabolism in c57bl/ksj-db/db mice, a model of type 2 diabetes mellitus. | recently, there has been a growing interest in alternative therapies of marine algae for diabetes. therefore, the anti-diabetic effects of brown alga, ecklonia cava was investigated in type 2 diabetic animal. male c57bl/ksj-db/db (db/db) mice were divided into control, dieckol rich extract of e. cava (ag-dieckol), or rosiglitazone (rg) groups. the blood glucose, blood glycosylated hemoglobin levels, and plasma insulin levels were significantly lower in the ag-dieckol and rg groups than in the co ... | 2011 | 22227338 |
| depressive effects on the central nervous system and underlying mechanism of the enzymatic extract and its phlorotannin-rich fraction from ecklonia cava edible brown seaweed. | marine plants have been reported to possess various pharmacological properties; however, there have been few reports on their neuropharmacological effects. terrestrial plants have depressive effects on the central nervous system (cns) because of their polyphenols which make them effective as anticonvulsants and sleep inducers. we investigated in this study the depressive effects of the polyphenol-rich brown seaweed, ecklonia cava (ec), on cns. an ec enzymatic extract (ecee) showed significant an ... | 2012 | 22232271 |
| evaluation of antioxidant properties of a new compound, pyrogallol-phloroglucinol-6,6'-bieckol isolated from brown algae, ecklonia cava. | in this study, antioxidant and free radical scavenging activities of the natural antioxidative compound, pyrogallol-phloroglucinol-6,6'-bieckol (ppb) isolated from brown algae, ecklonia cava was assessed in vitro by measuring the radical scavenging activities (dpph, alkyl, hydroxyl, and superoxide) using electron spin resonance (esr) spectrometry, intracellular reactive oxygen species (ros) scavenging activity, and dna damage assay. according to the results of these experiments, the scavenging a ... | 2011 | 22259673 |
| dieckol from ecklonia cava suppresses the migration and invasion of ht1080 cells by inhibiting the focal adhesion kinase pathway downstream of rac1-ros signaling. | we have previously isolated dieckol, a nutrient polyphenol compound, from the brown alga, ecklonia cava (lee et al.,2010a). dieckol shows both antitumor and antioxidant activity and thus is of special interest for the development of chemopreventive and chemotherapeutic agents against cancer. however, the mechanism by which dieckol exerts its antitumor activity is poorly understood. here, we show that dieckol, derived from e. cava, inhibits migration and invasion of ht1080 cells by scavenging int ... | 2012 | 22286230 |
| 6,6'-bieckol, isolated from marine alga ecklonia cava, suppressed lps-induced nitric oxide and pge₂ production and inflammatory cytokine expression in macrophages: the inhibition of nfκb. | ecklonia cava is an edible brown alga that contains high levels of phlorotannins, which are unique marine polyphenolic compounds. in the present study, we investigated the anti-inflammatory effects and the underlying molecular mechanism of phlorotannin 6,6'-bieckol, which is an active component isolated from e. cava, on lipopolysaccharide (lps)-stimulated primary macrophages and raw 264.7 macrophage cells. 6,6'-bieckol was found to inhibit nitric oxide (no) and prostaglandin e₂ (pge₂) production ... | 2012 | 22289571 |
| inhibitory effects of ecklonia cava extract on high glucose-induced hepatic stellate cell activation. | nonalcoholic steatohepatitis (nash) is a disease closely associated with obesity and diabetes. a prevalence of type 2 diabetes and a high body mass index in cryptogenic cirrhosis may imply that obesity leads to cirrhosis. here, we examined the effects of an extract of ecklonia cava, a brown algae, on the activation of high glucose-induced hepatic stellate cells (hscs), key players in hepatic fibrosis. isolated hscs were incubated with or without a high glucose concentration. ecklonia cava extrac ... | 2011 | 22363250 |
| ecklonia cava polyphenol protects the liver against ethanol-induced injury in rats. | the development of alcoholic liver disease is a complex process that involves both the parenchymal and non-parenchymal cells of the liver. we examined the effect of an ecklonia cava extract on ethanol-induced liver injury. | 2012 | 22387226 |
| antioxidant dieckol downregulates the rac1/ros signaling pathway and inhibits wiskott-aldrich syndrome protein (wasp)-family verprolin-homologous protein 2 (wave2)-mediated invasive migration of b16 mouse melanoma cells. | reactive oxygen species (ros) generation is linked to dynamic actin cytoskeleton reorganization, which is involved in tumor cell motility and metastasis. thus, inhibition of ros generation and actin polymerization in tumor cells may represent an effective anticancer strategy. however, the molecular basis of this signaling pathway is currently unknown. here, we show that the ecklonia cava-derived antioxidant dieckol downregulates the rac1/ros signaling pathway and inhibits wiskott-aldrich syndrom ... | 2012 | 22441674 |
| neuroprotective effects of phlorotannins isolated from a brown alga, ecklonia cava, against h2o2-induced oxidative stress in murine hippocampal ht22 cells. | exposure of neurons to hydrogen peroxide (h(2)o(2)) results in oxidative stress and the activation of a cascade of intracellular toxic events resulting in oxidation, lipid peroxidation, and ca(2+) elevation, ultimately resulting in cell death. in this study, we attempted to characterize the neuroprotective effects of phlorotannins isolated from ecklonia cava, including phloroglucinol, eckol, triphloroethol a, eckstolonol, and dieckol, against h(2)o(2)-induced cell damage in murine hippocampus ne ... | 2012 | 22465981 |
| phloroglucinol inhibits the bioactivities of endothelial progenitor cells and suppresses tumor angiogenesis in llc-tumor-bearing mice. | there is increasing evidence that phloroglucinol, a compound from ecklonia cava, induces the apoptosis of cancer cells, eventually suppressing tumor angiogenesis. | 2012 | 22496756 |
| hepatoprotective effects of dieckol-rich phlorotannins from ecklonia cava, a brown seaweed, against ethanol induced liver damage in balb/c mice. | alcoholic liver disease, which is one of the most serious liver disorders, has been known to cause by ethanol intake. in the present study, in vivo hepatoprotective effects of dieckol-rich phlorotannins (drp) from ecklonia cava, a brown seaweed, on ethanol induced hepatic damage in balb/c mice liver were investigated. after administration of 5 and 25mg/kg mouse of drp and 4 g/kg mice ethanol, the body weights and survival rates were increased as compared to the control, which is ethanol-treated ... | 2012 | 22504843 |
| insulinotrophic and hypolipidemic effects of ecklonia cava in streptozotocin-induced diabetic mice. | to explore the anti-diabetic activity of ecklonia cava (ec) in streptozotocin (stz)-induced diabetic mice. | 2012 | 22546654 |
| bioactive compounds extracted from ecklonia cava by using enzymatic hydrolysis protects high glucose-induced damage in ins-1 pancreatic β-cells. | pancreatic β-cells are very sensitive to oxidative stress and this might play an important role in β-cell death in diabetes. in the present study, we investigated whether the brown alga ecklonia cava has protective effects against high glucose-induced damage in ins-1 pancreatic β-cells. for that purpose, we prepared an enzymatic hydrolysate from e. cava (ehe) by using the carbohydrase, celluclast. high-glucose (30 mm) treatment induced glucotoxicity, whereas ehe prevented cells from high glucose ... | 2012 | 22644639 |
| ecklonia cava inhibits glucose absorption and stimulates insulin secretion in streptozotocin-induced diabetic mice. | aims of study. present study investigated the effect of ecklonia cava (ec) on intestinal glucose uptake and insulin secretion. materials and methods. intestinal na(+)-dependent glucose uptake (sgu) and na(+)-dependent glucose transporter 1 (sglt1) protein expression was determined using brush border membrane vesicles (bbmvs). glucose-induced insulin secretion was examined in pancreatic β-islet cells. the antihyperglycemic effects of ec, sgu, and sglt1 expression were determined in streptozotocin ... | 2012 | 22645628 |
| eckol inhibits ultraviolet b-induced cell damage in human keratinocytes via a decrease in oxidative stress. | in previous reports, the antioxidant effects of eckol were shown to protect cells against hydrogen peroxide- and gamma ray-induced oxidative stress. in this study, the role of eckol in protecting human skin keratinocytes (hacat) against uvb-induced oxidative cell damage was investigated. also, triphlorethol-a, one of the chemical components in ecklonia cava, and quercetin a well known antioxidant, were compared with eckol in terms of antioxidant activity based on chemical structure. eckol decrea ... | 2012 | 22687478 |
| effect of dieckol, a component of ecklonia cava, on the promotion of hair growth. | this study was conducted to evaluate the effect of ecklonia cava, a marine alga native to jeju island in korea, on the promotion of hair growth. when vibrissa follicles were cultured in the presence of e. cava enzymatic extract (which contains more than 35% of dieckol) for 21 days, e. cava enzymatic extract increased hair-fiber length. in addition, after topical application of the 0.5% e. cava enzymatic extract onto the back of c57bl/6 mice, anagen progression of the hair-shaft was induced. the ... | 2012 | 22754373 |
| protective efficacy of an ecklonia cava extract used to treat transient focal ischemia of the rat brain. | phlorotannins (marine algal polyphenols) have been reported to exhibit beneficial biological activities, serving as both antioxidants and anti-inflammatory agents. among marine algae, ecklonia cava, a member of the laminariaceae, is a very popular food regarded as healthy in korea and japan. recently, benefits afforded by phlorotannins in the treatment of various clinical conditions have been reported, but any therapeutic effects of such materials in the treatment of neurodegenerative diseases s ... | 2012 | 22822465 |
| polyphenol-rich fraction of brown alga ecklonia cava collected from gijang, korea, reduces obesity and glucose levels in high-fat diet-induced obese mice. | ecklonia cava (e. cava) is a brown alga that has beneficial effects in models of type 1 and type 2 diabetes. however, the effects of e. cava extracts on diet-induced obesity and type 2 diabetes have not been specifically examined. we investigated the effects of e. cava on body weight, fat content, and hyperglycemia in high-fat diet- (hfd) induced obese mice and sought the mechanisms involved. c57bl/6 male mice were fed a hfd (60% fat) diet or normal chow. after 3 weeks, the hfd diet group was gi ... | 2012 | 22844333 |
| dieckol isolated from ecklonia cava protects against high-glucose induced damage to rat insulinoma cells by reducing oxidative stress and apoptosis. | pancreatic β cells are very sensitive to oxidative stress and this might play an important role in β cell death with diabetes. the protective effect of dieckol, one of the phlorotannin polyphenol compounds purified from ecklonia cava (e. cava), against high glucose-induced oxidative stress was investigated by using rat insulinoma cells. a high-glucose (30 mm) treatment induced the death of rat insulinoma cells, but dieckol, at a concentration 17.5 or 70 µm, significantly inhibited the high-gluco ... | 2012 | 22878185 |
| photo-oxidative stress by ultraviolet-b radiation and antioxidative defense of eckstolonol in human keratinocytes. | ultraviolet-b (uv-b) irradiation has been known to generate oxidative stress by increasing reactive oxygen species (ros) in skin cells. several naturally occurring antioxidant compounds isolated from marine algae are believed to protect against ros. in this study, we assessed the antioxidative effect of eckstolonol isolated from ecklonia cava against uv-b-induced ros in human keratinocytes (hacats). we investigated the effects of photo-oxidative stress by uv-b (50 mj/cm(2)) and the antioxidative ... | 2012 | 22999063 |
| phlorotannin-rich ecklonia cava reduces the production of beta-amyloid by modulating alpha- and gamma-secretase expression and activity. | beta-amyloid (aβ) is a major pathogenic peptide in alzheimer's disease (ad) and is generated by the processing of amyloid precursor protein (app). we have previously reported that the brown algae ecklonia cava, which has anti-oxidant and anti-inflammatory functions, decreased aβ production and further aggregation in hek293 cells expressing the app swedish mutation. here, we show the reduction mechanism of aβ production using the butanol extract of ecklonia cava through the examination of express ... | 2013 | 23041113 |
| radio-protective effect of polysaccharides isolated from lactobacillus brevis-fermented ecklonia cava. | we investigated the radioprotective effects of a polysaccharide isolated from enzymatic extracts of ecklonia cava (e. cava) fermented by fungi and bacteria. we identified that the aqueous extract of the lactobacillus brevis-fermented e. cava especially showed the highest proliferation effect. in addition, the enzymatic extract prepared by enzyme-assisted extraction using viscozyme (vlfe) significantly increased cell proliferation. further study indicated that the polysaccharides isolated from th ... | 2013 | 23068138 |
| phloroglucinol protects small intestines of mice from ionizing radiation by regulating apoptosis-related molecules: a comparative immunohistochemical study. | phloroglucinol (pg) is a phenolic compound isolated from ecklonia cava, a brown algae abundant on jeju island, korea. previous reports have suggested that pg exerts antioxidative and cytoprotective effects against oxidative stress. in this study, we confirmed that pg protected against small intestinal damage caused by ionizing radiation, and we investigated its protective mechanism in detail. regeneration of intestinal crypts in the pg-treated irradiated group was significantly promoted compared ... | 2013 | 23117934 |
| effects of ecklonia cava polyphenol in individuals with hypercholesterolemia: a pilot study. | we evaluated the efficacy and safety of ecklonia cava polyphenol (seapolynol™, a polyphenol antioxidant and anti-inflammatory agent purified from e. cava) during a 12-week treatment period (400 mg orally once daily) in individuals with hypercholesterolemia and performed subgroup analysis for metabolic syndrome (mets). as a noncomparative study, forty-six individuals (m:f=22:24, mean age=54±11 years) with fasting total cholesterol concentration >240 mg/dl or low-density lipoprotein cholesterol (l ... | 2012 | 23126663 |
| anti-inflammatory effect of fucoidan extracted from ecklonia cava in zebrafish model. | fucoidan extracted from ecklonia cava had strong anti-inflammatory activities. however, the direct effects of fucoidan of e. cava on anti-inflammatory activities in vivo model remained to be determined. therefore, the present study was designed to assess in vivo anti-inflammatory effect of fucoidan extracted from e. cava (ecf) using tail-cutting-induced and lipopolysaccharide (lps)-stimulated zebrafish model. treating zebrafish model with tail-cutting and lps-treatment significantly increased th ... | 2013 | 23218269 |
| dieckol isolated from brown seaweed ecklonia cava attenuates type іі diabetes in db/db mouse model. | in the present study, the attenuation of type іі diabetes by dieckol, a phlorotannin derivative isolated from brown seaweed, ecklonia cava was investigated in c57bl/ksj-db/db, a type іі diabetes mouse model. dieckol was administered intraperitoneal injection at doses of 10 and 20 mg/kg body weight diabetes mice for 14 days. the blood glucose level, serum insulin level and body weight were significantly reduced in the dieckol administered group, compared to that of the saline administered group. ... | 2013 | 23261675 |
| the jnk/nfkappab pathway is required to activate murine lymphocytes induced by a sulfated polysaccharide from ecklonia cava. | the proven immunomodulatory and immune system activating properties of ecklonia cava (e. cava) have been attributed to its plentiful polysaccharide content. therefore, we investigated whether the sulfated polysaccharide (sp) of e. cava specifically activates the protein kinases (mapks) and nuclear factor-kappab (nfkappab) to incite immune responses. | 2013 | 23262141 |
| protective effect of marine algae phlorotannins against aaph-induced oxidative stress in zebrafish embryo. | in this study the protective effect of phlorotannins, including phloroglucinol, eckol, dieckol, eckstolonol and triphloroethol a, isolated from brown algae ecklonia cava was investigated against aaph-induced oxidative stress toxicity in zebrafish embryos. zebrafish embryos were exposed to aaph and compared with other groups that were co-exposed with phlorotannins until 2-days post-fertilisation. all phlorotannins scavenged intracellular ros and prevented lipid peroxidation and reduced aaph-induc ... | 2013 | 23411200 |
| cytoprotective effect of dieckol on human endothelial progenitor cells (hepcs) from oxidative stress-induced apoptosis. | although endothelial progenitor cells (epcs) have been used to promote revascularization after peripheral or myocardial ischemia, excess amounts of reactive oxygen species (ros) are often involved in senescence and apoptosis of epcs, thereby causing defective neovascularization and reduced or failed recovery. here, we examined the cytoprotective effect of ecklonia cava-derived antioxidant dieckol (dk) on oxidative stress-induced apoptosis in epcs to improve epc bioactivity for vessel repair. alt ... | 2013 | 23607503 |
| dieckol, a sars-cov 3cl(pro) inhibitor, isolated from the edible brown algae ecklonia cava. | sars-cov 3cl(pro) plays an important role in viral replication. in this study, we performed a biological evaluation on nine phlorotannins isolated from the edible brown algae ecklonia cava. the nine isolated phlorotannins (1-9), except phloroglucinol (1), possessed sars-cov 3cl(pro) inhibitory activities in a dose-dependently and competitive manner. of these phlorotannins (1-9), two eckol groups with a diphenyl ether linked dieckol (8) showed the most potent sars-cov 3cl(pro) trans/cis-cleavage ... | 2013 | 23647823 |
| studies on technology for seaweed forest construction and transplanted ecklonia cava growth for an artificial seaweed reef. | we installed seaweed reef for restoration of barron ground coast. we hollowed out a u-shaped groove in a cross-shaped artificial seaweed reef and covered it with a zinc sheet (u-bar) to transplant ecklonia cava growing on dellenia wood by hand, installing the u-bar on the artificial seaweed reef, fixing it with concrete. thus seaweed can be attached easily, with pre-installed stainless bolts and nuts. the length of ecklonia cava leaf transplanted to the cross-shaped reef was 7.2 cm in february 2 ... | 2012 | 23734467 |
| in vitro antiviral activity of phlorotannins isolated from ecklonia cava against porcine epidemic diarrhea coronavirus infection and hemagglutination. | despite the prepdominat agent causing severe entero-pathogenic diarrhea in swine, there are no effective therapeutical treatment of porcine epidemic diarrhea virus (pedv). in this study, we evaluated the antiviral activity of five phlorotannins isolated from ecklonia cava (e. cava) against pedv. in vitro antiviral activity was tested using two different assay strategies: (1) blockage of the binding of virus to cells (simultaneous-treatment assay) and (2) inhibition of viral replication (post-tre ... | 2013 | 23746631 |
| evaluation of inhibitory effect of phlorotannins from ecklonia cava on triglyceride accumulation in adipocyte. | in the present study, a methanolic extract of ecklonia cava and its solvent-partitioned fractions were evaluated for their antiadipogenic effect in 3t3-l1 adipocytes. one of them, the n-buoh fraction, effectively reduced lipid accumulation and glucose consumption. in addition, the presence of the n-buoh fraction in adipocytes suppressed the regulations of adipogenic transcription factors, pparγ and srebp1c, and adipogenic specific genes, fabp4, fabp1, fas, lpl, hsl, and acs1. further purificatio ... | 2013 | 23957842 |
| protective effect of dieckol isolated from ecklonia cava against ethanol caused damage in vitro and in zebrafish model. | in the present study, the protective effects of phlorotannins isolated from ecklonia cava against ethanol-induced cell damage and apoptosis were investigated both in vitro and in vivo. three phlorotannin compounds, namely phloroglucinol, eckol and dieckol, were successively isolated and identified from the extract. dieckol showed the strongest protective effect against ethanol-induced cell apoptosis in chang liver cells, with the lowest cytotoxicity. it was observed that dieckol reduced cell apo ... | 2013 | 24189014 |
| dieckol, a phlorotannin isolated from a brown seaweed, ecklonia cava, inhibits adipogenesis through amp-activated protein kinase (ampk) activation in 3t3-l1 preadipocytes. | in this study, we assessed the potential inhibitory effect of 5 species of brown seaweeds on adipogenesis the differentiation of 3t3-l1 preadipocytes into mature adipocytes by measuring oil-red o staining. the ecklonia cava extract tested herein evidenced profound adipogenesis inhibitory effect, compared to that exhibited by the other four brown seaweed extracts. thus, e. cava was selected for isolation of active compounds and finally the three polyphenol compounds of phlorotannins were obtained ... | 2013 | 24211593 |
| ecklonia cava promotes hair growth. | previous studies have reported the protective effects on skin elasticity of the edible marine seaweed ecklonia cava, which acts through regulation of both antioxidative and anti-inflammatory responses. | 2013 | 24252083 |
| inhibitory effects of brown algae extracts on histamine production in mackerel muscle via inhibition of growth and histidine decarboxylase activity of morganella morganii. | this study was performed to investigate the inhibitory effects of brown algae extracts on histamine production in mackerel muscle. first, antimicrobial activities of brown algae extracts against morganella morganii were investigated using a disk diffusion method. an ethanol extract of ecklonia cava (ecee) exhibited strong antimicrobial activity. the minimum inhibitory concentration (mic) of ecee was 2 mg/ml. furthermore, the brown algae extracts were examined for their ability to inhibit crude h ... | 2014 | 24394193 |
| anti-hyperlipidemic effect of polyphenol extract (seapolynol(™)) and dieckol isolated from ecklonia cava in in vivo and in vitro models. | the inhibitory effect of polyphenol extracts (seapolynol(™), spn) of the marine brown algae ecklonia cava and dieckol, a major component of spn, on hyperlipidemia was investigated in icr mice fed a high-fat diet (hfd) for five weeks. for analysis of the anti-hyperlipidemic effects of spn and dieckol, these two agents were given orally on a daily basis to hfd-fed mice for four weeks, starting one week after the beginning of hfd feeding. groups administered with spn as well as dieckol showed lower ... | 2012 | 24471056 |
| alleviating effects of baechu kimchi added ecklonia cava on postprandial hyperglycemia in diabetic mice. | in this study, we investigated the inhibitory effects of baechu kimchi added ecklonia cava on the activities of α-glucosidase and α-amylase and its alleviating effect on the postprandial hyperglycemia in stz-induced diabetic mice. baechu kimchi added ecklonia cava (bke, 15%) was fermented at 5°c for 28 days. optimum ripened bke was used in this study as it showed the strongest inhibitory activities on α-glucosidase and α-amylase by fermentation time among the bkes in our previous study. the bke ... | 2013 | 24471127 |
| protective effect of fucoidan against aaph-induced oxidative stress in zebrafish model. | fucoidan, extracted from ecklonia cava, has been extensively studied because of its wide biological activities. however, antioxidative activities have not been yet examined. therefore we evaluated in vitro and in vivo studies on antioxidative activities of e. cava fucoidan (ecf). ecf exhibited more prominent effects in peroxyl radical scavenging activity, compared to the other scavenging activities. thus, ecf was further evaluated for its protective ability against 2,2'-azobis dihydrochloride in ... | 2014 | 24507271 |
| marine algae-mediated synthesis of gold nanoparticles using a novel ecklonia cava. | in the present study, we report rapid biological synthesis of gold nanoparticles (au nps) using a novel marine brown alga ecklonia cava (family: lessoniaceae) by the reduction of chloroauric acid. the formation of au nps reaction was complete within 1 min at 80 °c and physiochemically characterized with different analytical techniques. ftir spectroscopy revealed that au nps were functionalized with biomolecules that have primary amine group, hydroxyl group and other stabilizing functional groups ... | 2014 | 24525832 |
| effects of the addition of ecklonia cava powder on the selected physicochemical and sensory quality of white pan bread. | physicochemical properties and consumer perception of white pan bread as influenced by the addition of ecklonia cava powder (ecp) were investigated. freeze-dried ecklonia cava were ground, sieved through a laboratory sieve and a fraction with particles less than 250 μm was used. amount of ecp added (0~3%) to the bread was found to affect the bread quality significantly (p<0.05). ph, bread height, and volume of the control was significantly higher than others (p<0.05) and decreased significantly ... | 2013 | 24551832 |
| protective effect of the edible brown alga ecklonia stolonifera on doxorubicin-induced hepatotoxicity in primary rat hepatocytes. | as part of our efforts to isolate anti-hepatotoxic agents from marine natural products, we screened the ability of 14 edible varieties of korean seaweed to protect against doxorubicin-induced hepatotoxicity in primary rat hepatocytes. | 2014 | 24628384 |