Publications

[eumycotic mycetomas in horses caused by curvularia verruculosa].	the fungus curvularia verruculosa, which produces eumycotic mycetomas, was isolated from skin of horses with granulomatous lesions on the legs. the isolation was made in sabouraud dextrose agar medium. the horses came from comandante fontana suburb, formosa-argentina. this finding would be the first report of curvularia in horses in argentina.	1994	7761602
exploration of single molecule events in a haloperoxidase and its biomimic: localization of halogenation activity.	in situ observation of single oxidation/halogenation events by catalytically generated hypobromite species using single molecule fluorescence microscopy allows monitoring of the diffusion behavior of these halonium species from the catalyst into the bulk solution. the fluororgenic probe specifically reacts with hypohalites, yielding fluorescein that can be detected with single molecule sensitivity. it was found for two investigated catalysts (curvularia verruculosa enzymes and tungstate-exchange ...	2008	18785736
e6201 [(3s,4r,5z,8s,9s,11e)-14-(ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1h-2-benzoxacyclotetradecine-1,7(8h)-dione], a novel kinase inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (mek)-1 and mek kinase-1: in vitro characterization of its anti-inflammatory and antihyperproliferative activities.	the goal of this study is to identify a novel inhibitor with anti-inflammatory and antiproliferative properties for the treatment of psoriasis. compound f152a1 [(3s,5z,8s,11e)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1h-benzo[c][1]oxacyclotetradecine1,7(8h)-dione] was identified as the main active metabolite with strong inhibitory activity against tumor necrosis factor-alpha (tnfalpha) transcription in a fraction originated from the fermentation broth of the fungus curvularia ve ...	2009	19684251
conformational analyses and mo studies of f152a1 and its analogues as potent protein kinase inhibitors.	f152a1 was isolated from a fermentation broth of curvularia verruculosa and characterized as a potent inhibitor of tnfalpha transcription, with anti-inflammatory activity. f152a1 and several analogues displayed inhibitory activity against the map kinases erk2 and mek1 in in vitro kinase assays. through sar studies on f152a1 and analogues prepared via total synthesis, we have identified structural features that contribute to inhibitory activity. to rationalize these results and to aid in the disc ...	2009	19995092
in vitro antifungal susceptibility and molecular identity of 99 clinical isolates of the opportunistic fungal genus curvularia.	the in vitro antifungal susceptibility of a set of 99 clinical isolates of curvularia was tested against 9 drugs using a reference microdilution method. the isolates had been identified previously to species level by comparing their its rdna and glyceraldehyde-3-phosphate dehydrogenase gene sequences with those of reference strains. we were able to reliably identify 73.2% of the isolates, the most frequent species being curvularia aeria, curvularia geniculata/curvularia senegalensis, curvularia ...	2013	23558007