Publications

comparison of trypanosoma grayi-like isolates from west and east africa.	three flagellates recently isolated from the hindguts of tsetse flies in west africa were compared with a previously described t. grayi-like trypanosome isolated in east africa. in media with microtus agrestis feeder layer cells, the flagellates developed into bloodstream-like trypomastigotes, which resembled the description of t. grayi from the blood of crocodiles. the results of isoenzyme electrophoresis suggest that the isolates are t. grayi-like trypanosomes, and that some variation exists b ...	1991	1888219
detection of infections of trypanosoma grayi in glossina fuscipes fuscipes in the central african republic.		1996	8915133
evolutionary history of trypanosomes from south american caiman (caiman yacare) and african crocodiles inferred by phylogenetic analyses using ssu rdna and ggapdh genes.	in this study, using a combined data set of ssu rdna and ggapdh gene sequences, we provide phylogenetic evidence that supports clustering of crocodilian trypanosomes from the brazilian caiman yacare (alligatoridae) and trypanosoma grayi, a species that circulates between african crocodiles (crocodilydae) and tsetse flies. in a survey of trypanosomes in caiman yacare from the brazilian pantanal, the prevalence of trypanosome infection was 35% as determined by microhaematocrit and haemoculture, an ...	2009	18980702
adaptin evolution in kinetoplastids and emergence of the variant surface glycoprotein coat in african trypanosomatids.	the kinetoplastids are an important group of protozoa from the excavata supergroup, and cause numerous diseases with wide environmental, economic and ecological impact. trypanosoma brucei, the causative agent of human african trypanosomiasis, expresses a dense variant surface glycoprotein (vsg) coat, facilitating immune evasion via rapid switching and antigenic variation. coupled to vsg switching is efficient clathrin-mediated endocytosis (cme), which removes anti-vsg antibody from the parasite ...	2013	23337175
the phylogeography of trypanosomes from south american alligatorids and african crocodilids is consistent with the geological history of south american river basins and the transoceanic dispersal of crocodylus at the miocene.	little is known about the diversity, phylogenetic relationships, and biogeography of trypanosomes infecting non-mammalian hosts. in this study, we investigated the influence of host species and biogeography on shaping the genetic diversity, phylogenetic relationship, and distribution of trypanosomes from south american alligatorids and african crocodilids.	2013	24499634
a draft genome for the african crocodilian trypanosome trypanosoma grayi.	the availability of genome sequence data has greatly enhanced our understanding of the adaptations of trypanosomatid parasites to their respective host environments. however, these studies remain somewhat restricted by modest taxon sampling, generally due to focus on the most important pathogens of humans. to address this problem, at least in part, we are releasing a draft genome sequence for the african crocodilian trypanosome, trypanosoma grayi anr4. this dataset comprises genomic dna sequence ...	2014	25977781
field and experimental evidence of a new caiman trypanosome species closely phylogenetically related to fish trypanosomes and transmitted by leeches.	trypanosoma terena and trypanosoma ralphi are known species of the south american crocodilians caiman crocodilus, caiman yacare and melanosuchus niger and are phylogenetically related to the tsetse-transmitted trypanosoma grayi of the african crocodylus niloticus. these trypanosomes form the crocodilian clade of the terrestrial clade of the genus trypanosoma. a pcr-survey for trypanosomes in caiman blood samples and in leeches taken from caimans revealed unknown trypanosome diversity and frequen ...	2015	26767165
phylogenetic analysis of the trypanosoma genus based on the heat-shock protein 70 gene.	trypanosome evolution was so far essentially studied on the basis of phylogenetic analyses of small subunit ribosomal rna (ssu-rrna) and glycosomal glyceraldehyde-3-phosphate dehydrogenase (ggapdh) genes. we used for the first time the 70kda heat-shock protein gene (hsp70) to investigate the phylogenetic relationships among 11 trypanosoma species on the basis of 1380 nucleotides from 76 sequences corresponding to 65 strains. we also constructed a phylogeny based on combined datasets of ssu-rdna, ...	2016	27180897