Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [studies on the constituents of anthriscus sylvestris hoffm. ii. on the components of the flowers and leaves (author's transl)]. | 1979 | 536891 | |
| [chemical components of the roots of anthriscus sylvestris hoffm. i. structures of an acyloxycarboxylic acid and a new phenylpropanoidester, anthriscusin (author's transl)]. | 1978 | 739385 | |
| [studies on the constituents of anthriscus sylvestris hoffm. i. on the components of the radix (author's transl)]. | 1978 | 748527 | |
| antiproliferative constituents in umbelliferae plants. iii. constituents in the root and the ground part of anthriscus sylvestris hoffm. | the meoh extract of the root and the ground part of anthriscus sylvestris hoffm. showed a high inhibitory activity against mk-1, hela, and b16f10 cell growth in vitro. the activity was found only in the chci3-soluble fractions. from the chci3-soluble fraction of the root, falcarindiol, 1-(3'-methoxy-4',5'-methylenedioxyphenyl)-1 xi-methoxy-2-propene, elemicin, and nemerosin were newly isolated in addition to deoxypodophyllotoxin (anthricin), anthriscusin, (-)-deoxypodorhizone, and anthriscinol m ... | 1998 | 9621422 |
| antiproliferative constituents in umbelliferae plants. iv. constituents in the fruits of anthriscus sylvestris hoffm. | the constituents in the fruit of anthriscus sylvestris hoffm. were investigated, and four lignans [deoxypodophyllotoxin, morelensin, (-)-deoxypodorhizone, and (-)-hinokinin], one phenylpropanoid [1-(3',4'-dimethoxyphenyl)-1 xi-hydroxy-2-propene], two phenylpropanoid esters [3',4'-dimethoxycinnamyl (z)-2-angeloyloxymethyl-2-butenoate and 3',4'-dimethoxycinnamyl (z)-2-tigloyloxymethyl-2-butenoate], and one polyacetylenic compound (falcarindiol) were isolated. their antiproliferative activity again ... | 1998 | 9621423 |
| cytotoxic constituents from the roots of anthriscus sylvestris. | activity-guided fractionation of the roots of anthriscus sylvestris resulted in the isolation and characterization of five cytotoxic compounds, deoxypodophyllotoxin (1), falcarindiol (2), and angeloyl podophyllotoxin (5) from the hexane soluble fraction and morelensin (3), bursehernin (4) from the chloroform soluble fraction. it is the first report of the occurrence of compound 5 in nature. | 1999 | 10230514 |
| components of male aggregation pheromone of strawberry blossom weevil, anthonomus rubi herbst. (coleoptera:curculionidae). | the strawberry blossom weevil, anthonomus rubi, is a major pest of strawberries in the united kingdom and continental europe. as part of a project to develop noninsecticidal control methods, the pheromone system of this species was investigated. comparison of volatiles produced by field-collected, overwintering individuals of each sex led to identification of three male-specific compounds--(z)-2-(3,3-dimethylcyclohexylidene)ethanol, (cis)-1-methyl-2-(1-methylethenyl)cyclobutaneethanol, and 2-(1- ... | 2001 | 11504023 |
| a fast and simple gc ms method for lignan profiling in anthriscus sylvestris and biosynthetically related plant species. | a new gc-ms method for monitoring lignans was developed to study the variation in plants and elucidate the biosynthetic steps. a simple and fast extraction procedure for lyophilised plant material was developed, giving a lignan-rich extract. a gc-ms method was set up using an apolar wcot fused silica column using a high temperature programme (150 degrees c to 320 degrees c at 15 degrees c min(-1)). this new gc-ms method gave a clear lignan profile of plant material. it was possible to show the l ... | 2001 | 11745025 |
| volatile components from anthriscus sylvestris (l.) hoffm. | the volatile components of fresh leaves and roots from anthriscus sylvestris (l.) hoffm., obtained through hydrodistillation, were analysed by gc and gc-ms. this was compared to dichloromethane extracts of both fresh and dried leaf and root material. the monoterpene fraction (69-70%) dominated, while beta-phellandrene (39-45%) was the main component in both the leaf and the root oil. other components in the leaf oil were beta-myrcene (17%), sabinene (6.2%), z-beta-ocimene (5.4%) and benzene acet ... | 2002 | 12214699 |
| biosynthesis of yatein in anthriscus sylvestris. | little is known about the biosynthesis of yatein, in spite of its importance as a typical heartwood lignan and a key biosynthetic intermediate of the antitumor lignan podophyllotoxin. the present study, based on individual administration of [13c]phenylalanine and deuterium labelled lignans and simultaneous administration of two distinct lignans labelled with deuterium atoms to anthriscus sylvestris, established the two independent branch pathways from matairesinol, one to afford yatein via thuja ... | 2003 | 12956064 |
| [isolation of luteolin-7-glycoside from the flowers of anthriscus sylvestris (l.) hoffm]. | 1959 | 13633430 | |
| a phytochemical study of lignans in whole plants and cell suspension cultures of anthriscus sylvestris. | in the roots of anthriscus sylvestris 12 different lignans were detected. arctigenin, dimethylmatairesinol, dimethylthujaplicatin, podophyllotoxin, 7-hydroxyyatein and 7-hydroxyanhydropodorhizol have not been previously reported to be present in a. sylvestris. in the cell suspension cultures, which were initiated for this study, trace amounts of deoxypodophyllotoxin could be detected. with these cell suspension cultures we carried out feeding experiments using deoxypodophyllotoxin, yatein and, a ... | 2003 | 14531024 |
| lignan profiles of indoor-cultivated anthriscus sylvestris. | in a previous study we have shown that different populations of anthriscus sylvestris (l.) hoffm. (apiaceae) yield significantly different lignan profiles. in this study we collected the seeds of a. sylvestris from 4 locations, one in england and three in the netherlands. the seeds germinated and were grown under identical laboratory conditions. after 5 months the plants were harvested and the lignan profile in the roots and aerial parts was analysed using gc-ms. the plants from the seeds of the ... | 2003 | 14648404 |
| deoxypodophyllotoxin reduces skin pigmentation of brown guinea pigs. | in this report, we have demonstrated that deoxypodophyllotoxin from anthriscus sylvestris (l.) hoffm decreases uv-induced skin pigmentation of brown guinea pigs. deoxypodophyllotoxin (0.05 % in propylene glycol: ethanol: water = 5 : 3:2) was topically applied twice daily for two weeks to dorsal skin of brown guinea pigs that were exposed to uv irradiation using a solar simulator. visual inspection and fontana-masson staining both demonstrated that deoxypodophyllotoxin reduced skin pigmentation a ... | 2004 | 15095159 |
| comparative studies on phenotypic plasticity of two herbs, changium smyrnioides and anthriscus sylvestris. | the endangered medicinal herb, changium smyrnioides can only be found in deciduous forest gaps within the middle to northern subtropical broad-leaved evergreen forest zone of china. the considerable plasticity of its shoot and root structure helps it to capture light more effectively in winter and early spring, and to adapt to the soil moisture conditions in its narrow habitat. another medicinal plant, anthriscus sylvestris, is of similar economic importance but commonly dis-tributed widely. in ... | 2004 | 15101098 |
| deoxypodophyllotoxin, a naturally occurring lignan, inhibits the passive cutaneous anaphylaxis reaction. | this study examined the effect of a podophyllotoxin derivative, deoxypodophyllotoxin (anthricin), which is a medicinal herb product isolated from anthriscus sylvestris hoffm. deoxypodophyllotoxin was tested in a rat pca (passive cutaneous anaphylaxis) assay by administering deoxypodophyllotoxin intraperitoneally (1.0 to 10 mg/kg, i.p.) and intravenously (0.25 to 1.0 mg/kg, i.v.). deoxypodophyllotoxin dose-dependently inhibited the pca reaction activated by anti-dinitrophenyl (dnp) ige. the pca i ... | 2004 | 15124098 |
| dual inhibition of cyclooxygenases-2 and 5-lipoxygenase by deoxypodophyllotoxin in mouse bone marrow-derived mast cells. | deoxypodophyllotoxin (anthricin) is a medicinal herbal product isolated from anthriscus sylvestris hoffm. that inhibits cyclooxygenase-2 (cox-2) and cox-1-dependent phases of prostaglandin d(2) (pgd(2)) generation in bone marrow-derived mast cells (bmmc) in a concentration-dependent manner with ic(50) values of 1.89 microm and 65.3 microm, respectively. this study also found that this compound inhibited cox-1 and 2-dependent conversion of the exogenous arachidonic acid to pgd(2) in a dose-depend ... | 2004 | 15187418 |
| deoxypodophyllotoxin (dpt) inhibits eosinophil recruitment into the airway and th2 cytokine expression in an ova-induced lung inflammation. | the effect of deoxypodophyllotoxin (dpt) isolated from anthriscus sylvestris hoffm. was evaluated in an in vivo animal model for antiasthmatic activity. dpt (1.0 to 5 mg/kg) was given orally to ovalbumin (ova)/alum-induced asthmatic mice. dpt reduced the number of infiltrated eosinophils in bronchoalveolar lavage (bal) fluid in a dose-dependent manner. dexamethasone (5 mg/kg), which was used as a positive control, also strongly inhibited the number of infiltrated eosinophils. the effect of dpt o ... | 2006 | 16732515 |
| deoxypodophyllotoxin content and antioxidant activity of aerial parts of anthriscus sylvestris hoffm. | deoxypodophyllotoxin content of the aerial parts of anthriscus sylvestris hoffm. growing at different altitudes was evaluated in comparison to the roots. the lignan accumulation in ground parts was at least double compared to aerial ones. in addition antioxidant-guided fractionation of the crude methanol extract of aerial parts was performed with the 2,2-diphenyl-1-picrylhydrazyl (dpph) test. active fractions contained mainly luteolin-7-o-glucoside and chlorogenic acid. antioxidant properties of ... | 2013 | 17137110 |
| lignans and coumarins from the roots of anthriscus sylvestris and their increase of caspase-3 activity in hl-60 cells. | a new lignan, sylvestrin (1), was isolated from the meoh-soluble fraction of the roots of anthriscus sylvestris hoffm. (umbelliferae), along with six lignans (2-7), three coumarins (8-10), and a polyacetylene (11). the structure of sylvestrin was determined to be 2-(3',4',5'-trimethoxybenzylidene)-3-(3'',4''-methylendioxybenzyl)-gamma-butyrolactone (1) by spectroscopic means, including 2d-nmr. the eleven compounds were assessed for their abilities to activate a caspase-3 in human promyeloid leuk ... | 2007 | 17603178 |
| characterization of in vitro metabolites of deoxypodophyllotoxin in human and rat liver microsomes using liquid chromatography/tandem mass spectrometry. | the in vitro metabolism of deoxypodophyllotoxin (dpt), a medicinal herbal product isolated from anthriscus sylvestris (apiaceae), was investigated in rats and human microsomes and human recombinant cdna-expressed cyps. the incubation of dpt with pooled human microsomes in the presence of nadph generated five metabolites while its incubation with dexamethasone (dex)-induced rat liver resulted in seven metabolites (m1-m7) with major metabolic reactions including mono-hydroxylation, o-demethylation ... | 2008 | 18050240 |
| the naturally occurring flavolignan, deoxypodophyllotoxin, inhibits lipopolysaccharide-induced inos expression through the nf-kappab activation in raw264.7 macrophage cells. | deoxypodophyllotoxin (dpt), a naturally occurring flavolignan with anti-inflammatory activity, was isolated from anthriscus sylvestris hoffm., and we examined its effects on the expression of inducible nitric oxide synthase (inos) in lipopolysaccharide (lps)-stimulated, murine macrophage-like raw264.7 cells. western blot analysis performed with specific anti-inos antibodies showed that a decrease in nitric oxide (no) was accompanied by a decrease in the inos protein level. to clarify the mechani ... | 2008 | 18591766 |
| deoxypodophyllotoxin, flavolignan, from anthriscus sylvestris hoffm. inhibits migration and mmp-9 via mapk pathways in tnf-alpha-induced hasmc. | the matrix metalloproteinases (mmp-9 and mmp-2) in aortic smooth muscle cells (smc) play key roles in the pathogenesis atherosclerosis. the smc migration into the vascular wall via the bloodstream is directly linked with mmp-9 expression. deoxypodophyllotoxin (dpt), a naturally occurring flavolignan with anti-inflammatory activity, was isolated from anthriscus sylvestris hoffm. and has been known inhibit the expression of mmp-9 in tumor necrosis factor-alpha (tnf-alpha) stimulated human aortic s ... | 2009 | 19013539 |
| antitumor activity of deoxypodophyllotoxin isolated from anthriscus sylvestris: induction of g2/m cell cycle arrest and caspase-dependent apoptosis. | an active compound having antitumor activity was isolated from the root of anthriscus sylvestris. structural studies revealed that it was deoxypodophyllotoxin (dppt), and its biological activity was evaluated in hela human cervix carcinoma cells. flow cytometric analysis showed that dppt arrests the cell cycle in the g2/m phase prior to apoptosis. the mechanisms of action of dppt involve inhibition of tubulin polymerization, dysregulation of cyclin a and cyclin b1 expression, and activation of c ... | 2009 | 19501508 |
| inhibitory effects of deoxypodophyllotoxin from anthriscus sylvestris on human cyp2c9 and cyp3a4. | deoxypodophyllotoxin (dpt) is a bioactive compound of anthriscus sylvestris (apiaceae). in the present study, the inhibition of cytochrome p450 (cyp) by dpt was evaluated in human liver microsomes (hlm) and the baculovirus-insect cell-expressed human cyps using a cocktail probe assay. when a mixture of specific cyp substrates was incubated with dpt in hlm, cyp2c9-catalyzed diclofenac 4-hydroxylation and cyp3a4-catalyzed midazolam 1-hydroxylation were strongly inhibited by dpt, with ic (50) value ... | 2010 | 19960413 |
| seasonal variations in the deoxypodophyllotoxin content and yield of anthriscus sylvestris l. (hoffm.) grown in the field and under controlled conditions. | deoxypodophyllotoxin (dpt) is the main lignan in anthriscus sylvestris . for this study two sets of experiments with 16 plants and seeds, collected from a wide geographical range, were carried out. the dpt content in roots was significantly lower (p < 0.05) when the plants were cultivated in a non-native environment. for field-grown plants the highest dpt content was found in march (second year): 0.15% w/w (dry weight) in roots; 0.03% w/w in aerial parts. for plants grown in the climate room, th ... | 2011 | 21604818 |
| identification of lignans and related compounds in anthriscus sylvestris by lc-esi-ms/ms and lc-spe-nmr. | the aryltetralin lignan deoxypodophyllotoxin is much more widespread in the plant kingdom than podophyllotoxin. the latter serves as a starting compound for the production of cytostatic drugs like etoposide. a better insight into the occurrence of deoxypodophyllotoxin combined with detailed knowledge of its biosynthestic pathway(s) may help to develop alternative sources for podophyllotoxin. using hplc combined with electrospray tandem mass spectrometry and nmr spectroscopy techniques, we found ... | 2011 | 21889175 |
| quantification of polyacetylenes in apiaceous plants by high-performance liquid chromatography coupled with diode array detection. | polyacetylenes are known for their biofunctional properties in a wide range of organisms. in the present study, the most frequently occurring polyacetylenes, i.e. falcarinol, falcarindiol, and falcarindiol-3-acetate, were determined in six genera of the apiaceae family. for this purpose, a straightforward and reliable method for the screening and quantification of the polyacetylenes using high-performance liquid chromatography coupled with diode array and mass spectrometric detection without ted ... | 2011 | 21950154 |
| [identification of ginseng and its counterfeit by laser raman spectroscopy]. | the objective of the present study is to identify ginseng and its false sample: anthriscus sylvestris, radix glehniae and balloonflower root by laser raman spectroscopy, second derivative raman spectroscopy. the structural information of the samples indicated that ginseng and its false samples contains a large amount of carbohydrates, since some characteristic vibration peaks of the carbohydrates, such 1 640, 1 432, 1 130, 1 086, 942, 483 cm(-'1) can be observed. the characteristic vibration pea ... | 2012 | 22715769 |
| in vitro regeneration of wild chervil (anthriscus sylvestris l.). | anthriscus sylvestris (l.) hoffm. (apiaceae) is a common wild plant that accumulates the lignan deoxypodophyllotoxin. deoxypodophyllotoxin can be hydroxylated at the c-7 position in recombinant organisms yielding podophyllotoxin, which is used as a semi-synthetic precursor for the anticancer drugs, etoposide phosphate and teniposide. as in vitro regeneration of a. sylvestris has not yet been reported, development of a regeneration protocol for a. sylvestris would be useful as a micropropagation ... | 2012 | 22719203 |
| anthricin isolated from anthriscus sylvestris (l.) hoffm. inhibits the growth of breast cancer cells by inhibiting akt/mtor signaling, and its apoptotic effects are enhanced by autophagy inhibition. | anthricin (deoxypodophyllotoxin) is a natural product isolated from anthriscus sylvestris (l.) hoffm. (apiaceae). here, we investigated the effect of anthricin on autophagy and mammalian target of rapamycin (mtor) signaling as anticancer actions in breast cancer cells. many studies have supported the contention that the phosphoinositide 3-kinase (pi3k)/akt/mtorc1 pathway is considerably deregulated in breast cancer and that autophagy plays important roles in the development of this type of cance ... | 2013 | 23818925 |
| antitumor constituents from anthriscus sylvestris (l.) hoffm. | bioassay-guided chemical investigation of the roots of anthriscus sylvestris (l.) hoffm. resulted in the isolation of nine compounds, whose structures were determined by spectroscopic methods. compound 1 was isolated from this plant for the first time and compounds 3 and 9 were first found from this genus. different polar fractions of a. sylvestris extract and compounds 1, 6-8 and 9 were evaluated for antitumor activities against hepg2 (human hepatocellular carcinoma), mg-63 (human osteosarcoma ... | 2014 | 24761904 |
| deoxypodophyllotoxin induces g2/m cell cycle arrest and apoptosis in sgc-7901 cells and inhibits tumor growth in vivo. | deoxypodophyllotoxin (dpt), a natural microtubule destabilizer, was isolated from anthriscus sylvestris, and a few studies have reported its anti-cancer effect. however, the in vivo antitumor efficacy of dpt is currently indeterminate. in this study, we investigated the anti-gastric cancer effects of dpt both in vitro and in vivo. our data showed that dpt inhibited cancer cell proliferation and induced g2/m cell cycle arrest accompanied by an increase in apoptotic cell death in sgc-7901 cancer c ... | 2015 | 25608854 |
| ethnomedicinal, phytochemical and pharmacological profile of anthriscus sylvestris as an alternative source for anticancer lignans. | anthriscus sylvestris (l.) hoffm. is a wild herbaceous plant common in most temperate regions. it has been used traditionally to treat headaches, as a tonic, as antitussive, antipyretic, analgesic and diuretic. the plant contains deoxypodophyllotoxin, which is proven to have antitumor and anti-proliferative effects, anti-platelet aggregation, antiviral, anti-inflammatory and insecticidal activity. deoxypodophyllotoxin is considered to be the plant's most important constituent, because of its pha ... | 2015 | 26287153 |
| deoxypodophyllotoxin suppresses tumor vasculature in huvecs by promoting cytoskeleton remodeling through lkb1-ampk dependent rho a activatio. | angiogenesis plays a critical role in the growth and metastasis of tumors, which makes it an attractive target for anti-tumor drug development. deoxypodophyllotoxin (dpt), a natural product isolated from anthriscus sylvestris, inhibits cell proliferation and migration in various cancer cell types. our previous studies indicate that dpt possesses both anti-angiogenic and vascular-disrupting activities. although the rhoa/ rhoa kinase (rock) signaling pathway is implicated in dpt-stimulated cytoske ... | 2015 | 26470595 |