Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| a clinical and bacteriological evaluation of the effect of sulphamethoxazole-trimethoprim in acne vulgaris, resistant to prior therapy with tetracyclines. | 42 patients with acne vulgaris, clinically resistant to prior therapy with tetracyclines, were evaluated after therapy with sulphamethoxazole-trimethoprim (400 + 80 mg) twice daily. initially and after 6, 12 and 18 weeks of treatment in each patient the different acne lesions were counted and pus specimens from unhealed pustules were taken for bacteriological analysis. complete remission or excellent results were obtained in 33 patients (79%) at the end of treatment despite a relative increase o ... | 1978 | 150980 |
| complement activation in acne vulgaris: in vitro studies with propionibacterium acnes and propionibacterium granulosum. | to better define the role of bacteria in inflammatory acne vulgaris, we have investigated the ability of four strains of propionibacterium acnes and three strains of propionibacterium granulosum to activate complement. complement activation was assayed by incubating normal human serum with varying concentrations of each strain and measuring residual total hemolytic complement activity. when serum was tested unaltered, p. acnes strains were approximately threefold more potent than an equal weight ... | 1978 | 153333 |
| [variations in the phagocytic potency of circulating leukocytes from rats which received a thermal injury. effects of an immunostimulation with corynebacterium granulosum (author's transl)]. | experiments were carried out to study in vitro the variations of phagocytic activity of circulating leukocytes from rats which received a thermal injury and were either immunostimulated or not by a single iv injection of c. granulosum. the thermal injury which was applied at about 10 percent of the body surface was of an intermediary type ; it developed towards necrosis before cicatrising on about the 30th day. phagocytic activity was expressed as the percentage of "active" phagocytes or of thos ... | 1978 | 370744 |
| studies on the immunostimulating and anti-tumour activity of a fraction isolated from corynebacterium granulosum. | the immunostimulating activity of the anaerobic corynebacteriae is well documented. fractions isolated from while cells have not been much investigated. we have reported that the immunostimulating activity is present in fractions isolated from corynebacterium granulosum. a few fractions have shown anti-tumour activity in grafted tumours in mice. one of these fractions (p 40) has been investigated in more detail, since it proved to be inhibitory when administered after grafting of the non-syngeni ... | 1977 | 415918 |
| comparative studies of porphyrin production in propionibacterium acnes and propionibacterium granulosum. | porphyrin production by propionibacterium acnes and that by propionibacterium granulosum were compared. porphyrin synthesized by both organisms was identified as coproporphyrin iii on the bases of absorption and fluorescence spectra and behavior on paper chromatography and thin-layer chromatography. quantitative, rather than qualitative, differences in production were found between these organisms. in general, p. granulosum produced significantly greater amounts (p less than 0.001) of porphyrin ... | 1978 | 637914 |
| selective antibacterial action of 2-mercaptoethanol on propionibacteria in skin cultures. | 2-mercaptoethanol applied to the surface of agar medium had a selective antibacterial effect on propionibacterium acnes and propionibacterium granulosum without interfering with the growth of peptococcus saccharolyticus or staphylococci in anaerobic cultures of skin or in pure cultures. in aerobic broth culture, 2-mercaptoethanol inhibited aerobes and stimulated anaerobes, consistent with its action as a reducing agent. | 1979 | 760636 |
| effects of corynebacterium granulosum on weight and histology of lymphoid organs, response to mitogens, skin allografts, and a syngeneic fibrosarcoma in mice. | we studied the effect of single and multiple injections of corynebacterium granulosum on weight and histology of lymph nodes and spleen, on peripheral white blood cell count, response of peripheral blood lymphocytes, lymph node, and spleen cells to phytohemagglutinin and pokeweed mitogen, survival of skin allografts, and lung metastases of a syngeneic fibrosarcoma in c3hf/bu mice. corynebacterium parvum was used in some studies on antitumor activity. the weight of lymph nodes and spleen was mark ... | 1975 | 807323 |
| mitogenic activity of the cell walls of mycobacteria, nocardia, corynebacteria and anaerobic coryneforms. | the mitogenic activity of the cell walls prepared from mycobacterium bovis bcg, nocardia rubra, corynebacterium diphtheriae pw8, and four species of propionibacterium, corynebacterium parvum atcc 11829, propionibacterium acnes c7, propionibacterium granulosum atcc 25564 and propionibacterium avidum atcc 25577, were investigated. these cell walls were active as mitogens on normal spleen cells, anti-o sera-treated spleen cells, macrophage-depleted spleen cells of c57bl/6j mice and cortisone-treate ... | 1976 | 824484 |
| [immunization by canadida albicans and non-specific immunostimulation by corynebacterium granulosum and bcg in experimental candidiasis]. | immunostimulation by corynebacterium granulosum (whole bacteria or a delipided fraction p40) or by live bcg enhanced the resistance of lethally infected mice by candida albicans. the protection is greater by association with an active specific immunization by various preparations of c. albicans. | 1976 | 825252 |
| [antagonistic effect of a fraction isolated from corynebacterium granulosum toward cyclophosphamide immunosuppression in mice]. | a fraction isolated from corynebacterium granulosum was shown to be capable of increasing significantly the antibody level in response to immunization of the mouse with sheep red blood cells. the animals stimulated with this fraction become very resistant to the effect of cyclophosphamide. in contrast, the action of the fraction in previously immuno-suppressed animals is nil or very low. | 1976 | 825323 |
| regression of a hamster melanoma with intralesional corynebacterium granulosum. | the present study was undertaken to compare the antitumour effects of intralesionally administered corynebacterium granulosum, corynebacterium parvum, bcg and saline on a hamster melanoma. forty-eight golden hamsters were inoculated subcutaneously with forthers melanotic melanoma no. 1. twenty-four animals bore palpable tumours which were excised. no non-excised group animal showed primary tumour regression. in the excised group, the tumours generally recurred at the excision site in the c. parv ... | 1976 | 949459 |
| concomitant immunity to pulmonary metastases of a murine fibrosarcoma: influence of removal of primary tumor by radiation or surgery, of active specific immunization and treatment with corynebacterium granulosum. | 1976 | 993093 | |
| [protective effects of bacterial immunostimulants in mice infected by "klebsiella pneumoniae" resistant to antibiotics after mutation or by plasmid transfer]. | a streptomycin-resistant strain of k. pneumoniae obtained after mutation in vitro was found to be less virulent than the sensitive strain in mice. however, a single injection of lipopolysaccharides (lps) administered 24 hours before challenge increased the host's resistance to both strains. in contrast, the virulence was not changed in k. pneumoniae accepting r-factors for ampicillin, streptomycin, chloramphenicol, tetracycline and sulphonamide. the plasmids were transferred to k. pneumoniae fro ... | 1975 | 1101801 |
| nonspecific immunotherapy of murine solid tumors with corynebacterium granulosum. | a single intraperitoneal (ip) or intravenous (iv) injection of corynebacterium granulosum into c3hf/bu mice shortly after subcutaneous (sc) injection of cells from a strongly antigenic syngeneic fibrosarcoma induced by 3-methylcholanthrene caused complete and lasting regressions of 100 and 70% of resulting tumors, respectively. treatment with this bacterium sc only slightly inhibited the growth of some tumors. c. granulosum given iv to mice 3 days after the sc injection of fibrosarcoma cells cau ... | 1975 | 1127718 |
| esterification of (4--14c)cholesterol by cutaneous bacteria (staphylococcus epidermidis, propionibacterium acnes, and propionibacterium granulosum). | cholesterol and cholesteryl esters constitute 3 to 5% of the lipids derived from human sebaceous glands. the present study demonstrates that cutaneous bacteria, staphylococcus epidermidis, and to a lesser extent propionibacterium acnes, and propionibacterium granulosum, esterify [4--14c]cholesterol to steryl esters in vitro. the degree of esterification is a characteristic of the strain of organism, ranging from 0 to 32.7% in the organisms tested. cholesterol esterification in these experiments ... | 1975 | 1141713 |
| in vitro destruction of tumor cells by macrophages from mice treated with corynebacterium granulosum. | peritoneal macrophages from c3hf/bu mice treated with killed corynebacterium granulosum bacteria were tested for their effect on in vitro growth of syngeneic fibrosarcoma cells, tumorigenic mouse l-p59 cells, human malignant melanoma cells, allogeneic fibroblasts, erythrocytes, and epithelial kidney cells. only the cell cultures having neoplastic properties were destroyed by stimulated macrophages; the rate of tumor cell destruction was greater as the ratio of effector to target cells was increa ... | 1975 | 1159835 |
| induction of various cytokines in mice and activation of the complement system in rats as a part of the mechanism of action of the corynebacterium granulosum-derived p40 immunomodulator. | the capacity of the corynebacterium granulosum-derived p40 immunomodulator to induce in mice the formation of various cytokines ifn, il-1, il-2, alpha-tnf as well as to activate the complement system in rats was investigated. the results showed that p40 injected by the intravenous route was capable of inducing the formation of all four cytokines. high levels of ifn were measured 2 h after p40 stimulation and were still present at 24 h. the kinetic study of il-1, il-2 and alpha-tnf induction show ... | 1992 | 1384603 |
| inhibition of neutrophil chemotactic factor production in comedonal bacteria by subminimal inhibitory concentrations of erythromycin. | the effect of 1/10 minimal inhibitory concentrations (sub-mic) of erythromycin (em) on human neutrophil chemotactic factor production in comedonal bacteria, propionibacterium acnes strains, propionibacterium granulosum strains and coagulase-negative staphylococcus (cns) strains was assayed using the boyden chamber method. sub-mic of em significantly suppressed neutrophil chemotactic factor production in all strains of p. acnes, p. granulosum and cns. our results suggest that sub-mic of em may ha ... | 1992 | 1386264 |
| immunotherapy of chronic active viral hepatitis b with propionibacterium granulosum kp-45 (a 5-year follow-up report). | in the period 1982 to 1984, 14 hbs-ag-positive patients with chronic active hepatitis b were treated monthly with a cell wall preparation (5 or 10 mg) of propionibacterium granulosum kp-45 (pg), intravenously administered for a period of 6 to 10 months. all 14 patients were monitored by serological and biochemical tests as well as liver biopsy two, three and five years after completing immunotherapy with pg. during this period the patients received neither a specific antiviral, corticosteroid or ... | 1992 | 1427577 |
| comparative activity of the topical quinolone opc-7251 against bacteria associated with acne vulgaris. | the antibacterial activity of the topical quinolone opc-7251 against bacteria commonly found in acne vulgaris was tested in vitro by an agar dilution method. the mic50 was 0.25 mg/l for propionibacterium acnes, 0.125 mg/l for propionibacterium granulosum, 0.03 mg/l for staphylococcus aureus and 0.06 mg/l for coagulase-negative staphylococci. compared with seven other antibiotics tested (ciprofloxacin, penicillin, erythromycin, tetracycline, clindamycin, fusidic acid and gentamicin), opc-7251 had ... | 1992 | 1486893 |
| [comparison of the results of the treatment of patients with sspe using various immunomodulating preparations]. | the authors analysed the results of controlled treatment by three methods of patients in the 1st or 2nd phase of sspe in a randomized group. the groups received: i. propionibacterium granulosum kp-45 (interferon inducer) + isoprinosine, ii--tfx (thymus extract) + isoprinosine, iii--only isoprinosine. in all groups the treatment was continued during 6 months. the analysis of the clinical results of these methods failed to demonstrate a statistically significant superiority of any of these methods ... | 1991 | 1725554 |
| characterization of the binding of propionibacterium granulosum to glycosphingolipids adsorbed on surfaces. an apparent recognition of lactose which is dependent on the ceramide structure. | the binding properties of a strain of propionibacterium granulosum derived from human skin was investigated with reference to glycosphingolipids separated on thin layer chromatograms or coated in microtiter wells using externally (125i) and metabolically [( 35s]methionine) labeled bacteria. binding was found to lactosylceramide (laccer; gal beta 1-4glc beta 1-cer) but not to glycolipids lacking the lactose sequence (i.e. glc beta 1-cer, gal beta 1-cer or gal alpha 1-4gal beta 1-cer). in microtit ... | 1990 | 2358460 |
| postoperative propionibacterium granulosum endophthalmitis. | 1990 | 2383189 | |
| immunomodulators and allergy. | the role played by immunomodulation in allergy is critically reviewed. the prospective mechanisms of immunomodulation, specifically including those showing relation with allergic phenomena, are taken into consideration, examining the main interfering factors. type i, ige-mediated immunoreaction, in its two aspects, ige synthesis and mediator's release, is analyzed, bearing in mind some agents involved or affecting these processes, mimicking immunomodulation. other agents, such as corynebacterium ... | 1985 | 2412571 |
| evaluation of corynebacterium granulosum derived p40 fraction effects on macrophage anti-herpes simplex virus type 1 functions. | 1985 | 2417550 | |
| [propionibacterium granulosum kp-45 in the treatment of subacute sclerosing panencephalitis]. | 3 groups of patients, who suffered on sspe (without treatment, with isoprinosine therapy, combined treatment with propionibacterium granulosum and isoprinosine) are compared. the results show a favourable effect of the combined treatment in a part of the patients. they are discussed in detail. | 1989 | 2475877 |
| macrolide-lincosamide-streptogramin b (mls) resistance in cutaneous propionibacteria: definition of phenotypes. | erythromycin-resistant propionibacteria isolated from the skin of antibiotic-treated acne patients were found to express four different patterns of resistance to a set of eight mls antibiotics. the majority of isolates (48/89 strains) were constitutively resistant to 14- and 16-membered ring macrolide, lincosamide and streptogramin b-type antibiotics. mics of josamycin (0.5-16 mg/l) and spiramycin (0.5-128 mg/l) were lower than those of erythromycin, oleandomycin and tylosin (64 to less than 512 ... | 1989 | 2501269 |
| erythromycin resistant propionibacteria in antibiotic treated acne patients: association with therapeutic failure. | erythromycin resistant (emr) propionibacteria were isolated from the skin surface of 51% of patients treated with oral erythromycin and 42% of patients treated with topical clindamycin compared with 3% of untreated control subjects (p less than 0.001). amongst the topical clindamycin-treated patients, there was a higher incidence of emr propionibacterial carriage in those patients who had previously been treated with oral erythromycin (64%) than in patients with no known previous exposure to ery ... | 1989 | 2527056 |
| two-dimensional gel electrophoresis of ribosomal proteins from propionibacterium acnes and granulosum. | ribosomal proteins (r-proteins) from a type i strain (atcc 11827) and a type ii strain (atcc 11828) of propionibacterium acnes (p. acnes) and from a propionibacterium granulosum (p. granulosum) strain (atcc 11829-2) were analyzed using two-dimensional polyacrylamide gel electrophoresis (two-dimensional page), for the purpose of genetical analysis of the p. acnes type i and type ii strains and the p. granulosum strain. among the fifty r-proteins in all, almost all of the proteins were electrophor ... | 1989 | 2818796 |
| suppression of the activity of natural killer-like cells by peritoneal macrophages obtained from lewis lung tumor-bearing, propionibacterium granulosum kp-45-treated, or normal, untreated mice. | peritoneal adherent cells (pac) obtained from propionibacterium granulosum kp-45-treated or lewis lung carcinoma-bearing bdf1 mice suppressed in vitro the nk-like cytotoxic activity of murine splenocytes against yac-1 tumor target cells. maximum inhibition occurred when suppressor and effector cells were preincubated together for 18 h, but the effect was demonstrable also when the two groups of cells were mixed only at the onset of the 4-h cytotoxic assay (i.e. without previous contact). inhibit ... | 1987 | 2966102 |
| granulocyte activating factor released from propionibacterium acnes. a possible mediator of inflammation in acne vulgaris. | incubation of propionibacterium acnes but not of propionibacterium granulosum or propionibacterium avidum (for 30 min at 37 degrees c in physiological saline) released a soluble factor that produced enhanced chemiluminescence response of human granulocytes as well as increased chemotactic motility of these cells. sephadex g-25 filtration of the granulocyte activating factor (gaf) revealed its low molecular weight and apparent peptide character. thus, gaf may be a stimulus for inflammation in acn ... | 1988 | 2975904 |
| small-cell lung cancer and immunochemotherapy with propionibacterium granulosum kp 45. | seventy-nine patients with small-cell lung cancer were treated with vincristin, methotrexate, and cyclophosphamide in inductive therapy and with methotrexate, cyclophosphamide, and procarbazine in maintenance therapy. patients were divided at random into two groups: one group received chemotherapy alone and the second group was additionally subjected to systemic immunotherapy with propionibacterium granulosum strain kp-45. in general, differences in the frequency of therapy response and in durat ... | 1985 | 2982882 |
| the restoration of impaired macrophage functions using as immunomodulator the corynebacterium granulosum-derived p40 fraction. | many microorganisms and compounds of microbial origin exhibit immunomodulatory activities and have been extensively used in immunotherapy of experimental animal tumors and in patients with neoplasia. in this paper we describe the effect of the c. granulosum-derived p40 fraction on the growth and metastatization of the transplantable epithelioma t8 of guèrin. moreover, we evaluated the effect of p40 treatment on several depressed macrophage functions of tumor-bearing rats. in particular, the phag ... | 1985 | 2997082 |
| synergy between low-dose chemotherapy and immunotherapy in mouse l1210 leukemia. | a high dose of 4 mg/kg of daunorubicin (dau) given in combination with immunostimulation by the p40 immunomodulatory fraction of corynebacterium granulosum and glutaraldehyde (ga)-treated tumor cells coupled with tetanus toxoid (p40 + ga-l1210-tet) was more effective than dau alone for treatment of l1210 mouse leukemia. a combination of low doses of dau (0.0625-0.25 mg/kg) and p40 + ga-l1210-tet was more effective than either p40 + ga-l1210-tet or dau alone. the cured mice were resistant to chal ... | 1987 | 3102055 |
| the corynebacterium granulosum-derived p40 immunomodulator exerts a synergistic effect on the activity of antiviral drugs in the treatment of experimental viral infections. | comparative studies have been carried out on the effects on 2 viral-infection models (herpes virus and influenza virus) of treatments consisting of either c. granulosum-derived immunomodulator p40, or of vidarabin or amantadine as antiviral drugs, or of combinations of vidarabin or amantadine with p40. according to the modalities of administration of the p40 or of the antiviral drugs, the anti-infectious effect was more or less marked. in contrast, the combinations of p40 and antiviral drugs did ... | 1988 | 3179407 |
| [effect of propionibacterium granulosum kp-45 on the resistance to listeria monocytogenes and salmonella typhimurium infections]. | killed bacterial cells of propionibacterium granulosum kp-45 were found to be potent modifiers of non-specific resistance of mice against infection with either listeria monocytogenes or salmonella typhimurium. injection of p. granulosum 7 days prior to infection resulted in marked splenomegaly. disseminated acute inflammatory foci were found histologically in the liver. these mice were apparently less susceptible to infection, since definitely lower bacterial counts were determined. simultaneous ... | 1988 | 3287804 |
| [preoperative nonspecific immunostimulation with propionibacterium granulosum kp-45 in patients with colorectal cancer. a prospective randomized study]. | the effect of preoperative unspecific immunomodulation with propionibacterium granulosum kp-45 (p.g.) on postoperative complications and patient survival was evaluated in a prospectively randomized trial in patients with colorectal tumor resection. patients of the therapy group (n = 51) received at least 3 days before operation an infusion of 10 mg p.g., patients of the control group (n = 49) were not treated at all. the wound infection rate and the number of re-explorations were significantly l ... | 1988 | 3289850 |
| beneficial response of local immunotherapy with propionibacterium granulosum kp-45 in combined treatment of inflammatory breast carcinoma. | nine 44- to 67-year-old patients with inflammatory breast carcinoma were treated over 2 weeks with intratumoral injections of propionibacterium granulosum kp-45 (kp). this period of immunotherapy was succeeded by four courses of chemoimmunotherapy (fac: 5-fluorouracil, adriamycin, and cyclophosphamide + intratumoral kp). inflammatory symptoms disappeared in three patients during immunotherapy and in the remaining six patients during the following chemoimmunotherapy. finally, 3 to 4 months after ... | 1988 | 3410883 |
| septicemia caused by propionibacterium granulosum in a compromised patient. | a case of septicemia caused by propionibacterium granulosum in a compromised patient is described. the patient responded to ampicillin therapy. detailed antibiotic susceptibility data are presented. | 1987 | 3429632 |
| the influence of killed propionibacterium granulosum on experimental infection with escherichia coli. | mice infected subcutaneously with 5 x 10(3) viable cells of escherichia coli atcc 25922 incorporated in liquified agar developed a systemic infection. increasing bacterial numbers could be recovered from the liver at several days following infection. ultimately, the animals died 6 days after infection. treatment of mice with 1 mg killed propionibacterium granulosum kp-45 lead to an increased spleen weight at day 7 after intraperitoneal injection. hence, the animals were highly susceptible to the ... | 1987 | 3553883 |
| thermoimmunotherapy of advanced neoplasms. a concept and preliminary results. | a rationale for the use of local hyperthermia (lh) in cases of advanced neoplasms as well as indications for its therapeutic application are discussed. lh applied alone is of limited use, only about 50% of patients with advanced neoplasms benefit from this therapy, with a complete remission (cr) rate of 10-15%. thus lh should be considered as a supplementary form of cytoreductive therapy and it should be combined with other antineoplastic modalities. clinical studies on thermoimmunotherapy (a co ... | 1987 | 3607266 |
| preliminary experimental and clinical results with inactivated allergens conjugated to the corynebacterium granulosum-derived immunomodulator p40. | allergoids have been used successfully for immunotherapy of allergic disorders. it has appeared to us that the effect of allergoids could be potentiated by their coupling to an immunomodulator. in the present study we show that a conjugate made up of the coupling of ovalbumin through glutaraldehyde action to the c. granulosum-derived immunomodulator p40 is completely devoid of antigenicity and of cross-reactivity with ovalbumin. this conjugate was found to significantly inhibit mast cell degranu ... | 1987 | 3620123 |
| [use of propionibacterium granulosum kp 45 in the combined treatment of the inflammatory form of breast cancer]. | 1986 | 3786155 | |
| local immunotherapy with propionibacterium granulosum kp-45 in advanced breast cancer. | 50 patients with advanced metastatic breast cancer were matched into 25 "twin" pairs. in each pair, one "twin" received chemotherapy (fac) and the other received chemoimmunotherapy (fac + intratumorally propionibacterium granulosum kp-45 (pg)). the therapeutic effects of this 2-year follow-up study were carefully documented and analysed. the mean survival time of fac + pg-treated patients was about 17 months as compared to 8.5 months in fac controls. pg-therapy responders showed increasing value ... | 1985 | 3840665 |
| [effect of intratumor administration of propionibacterium granulosum in patients with advanced breast carcinoma on the clinical course of the disease and the behavior of certain indices of immune resistance]. | 1985 | 3880373 | |
| complete regressions of an established murine fibrosarcoma induced by systemic application of corynebacterium granulosum. | 1974 | 4412549 | |
| regression of a transplantable hamster melanoma by intralesional injections of corynebacterium granulosum. | 1974 | 4593141 | |
| specificity of a bcg-induced pulmonary granulomatous response in rabbits. | the specificity of bacillus calmette guérin (bcg)-induced accelerated pulmonary granuloma formation has been evaluated in rabbits by cross sensitization-challenge experiments by using another granulomagenic organism, corynebacterium granulosum. bcg-sensitized rabbits responded to challenge with homologous but not heterologous antigen, indicating that bcg-induced accelerated granuloma formation displays specificity characteristic of immunological reactions. these differences were also observed in ... | 1973 | 4764403 |
| protection by corynebacterium granulosum against radiation-induced enhancement of artificial pulmonary metastases of a murine fibrosarcoma. | 1974 | 4834415 | |
| destruction of hamster ovarian cell cultures by peritoneal macrophages from mice treated with corynebacterium granulosum. | 1974 | 4857795 | |
| [infection due to corynebacterium granulosum appearing under the aspect of a subacute gummatous lymphangitis]. | 1966 | 5942305 | |
| [hbs-antigen-positive chronic aggressive hepatitis]. | in the treatment of hbs-ag positive, chronic aggressive hepatitis three therapeutic methods can principally be applied: immunosuppression, immunostimulation and an attempt at medicamentous inhibition of the virus propagation. according to the present view, the immunosuppressive treatment with glucocorticoids and azathioprine is very risky in the antigen positive form and doubtful as far as the application is concerned; it simply suppresses the defensive reaction of the organism, thus encouraging ... | 1984 | 6202611 |
| immunotherapy of chronic active viral hepatitis b with propionibacterium granulosum. | 12 hbsag-positive patients with chronic active hepatitis b were treated monthly with cell walls (5 or 10 mg) of propionibacterium granulosum kp-45 (pg) intravenously administered for a period of 6-10 months. the clinical state was evaluated according to an arbitrary 6-grade scale based on serum biochemical tests, hbv markers and the morphology of liver biopsy samples. intravenous administration of pg was well tolerated, and no serious side effects were observed. all patients exhibited complete o ... | 1984 | 6205967 |
| effect of corynebacterium granulosum immunopotentiation on the pathogenesis of herpes simplex virus type 2 in balb/c mice. | treatment of 4- to 6-week-old, 18- to 22-g male balb/c mice with 0.6 mg of corynebacterium granulosum resulted in a significant decrease in mortality due to challenge with herpes simplex virus type 2 (hsv-2). optimal protection occurred when c. granulosum was injected 1 week before hsv-2 infection. c. granulosum-induced resistance to hsv-2 lasted up to 4.5 weeks. studies involving immune spleen cell transfer and treatment with antilymphocyte serum demonstrated the importance of cell-mediated im ... | 1980 | 6262241 |
| effects of ph on biomass, maximum specific growth rate and extracellular enzyme production by three species of cutaneous propionibacteria grown in continuous culture. | three cutaneous propionibacteria, propionibacterium acnes, propionibacterium avidum and propionibacterium granulosum, were grown in chemostats using semi-synthetic medium at various ph values. growth occurred between ph 4.5 and 7.5 for p. acnes and ph 5.0 and 8.0 for p. avidum and p. granulosum. the highest mumax was at ph 6.0 for the three species. maximum biomass production was obtained at ph 6.0 for p. acnes and p. avidum and at ph 7.5 for p. granulosum. extracellular enzyme production occurr ... | 1983 | 6311940 |
| cytotaxin production by comedonal bacteria (propionibacterium acnes, propionibacterium granulosum and staphylococcus epidermidis). | the potential role of different species of comedonal bacteria as chemotactic stimuli in the inflammatory phase of acne vulgaris was investigated by comparing 12 strains of staphylococcus epidermidis, 11 strains of propionibacterium acnes, and 5 strains of p. granulosum for production of cytotaxin in vitro. results indicated that not only were there marked differences in cytotaxin production between different strains of the same species grown under identical growth conditons, but there were often ... | 1980 | 6444322 |
| [inhibition of propionibacteria in the sebaceous gland duct using photochemotherapy and 8-methoxypsoralen]. | it was shown by in vitro studies that 8-methoxypsoralen (= 8 mop) alone and uva irradiation alone produces relatively little inhibition of the growth of propionibacterium acnes and propionibacterium granulosum, whereas a combination leads to an intense suppression of bacterial growth. it was further demonstrated by in vivo studies on 14 subjects that local treatment with 8 mop and uva significantly reduces the propionibacteria in the pilosebaceous duct. these results afford a possible explanatio ... | 1980 | 6446813 |
| stimulatory effect of propionibacterium granulosum kp-45, glucan and pyran copolymer on the activity of natural killer (nk) cells in murine lungs. | propionibacterium granulosum kp-45, glucan and pyran copolymer stimulated the elimination of 75selenomethionine-labelled 3ll tumor cells from murine lungs, as measured 4 hr after intravenous injection of these cells into 16- to 25-week-old b6df1 mice. this effect was most pronounced 4 to 6 days following intravenous administration of the above biological response modifiers and disappeared 6 to 8 days later. intraperitoneal injection of all three agents produced only insignificant stimulation res ... | 1984 | 6510946 |
| experimental and clinical results with the corynebacterium granulosum-derived immunomodulator p40. | 1984 | 6529476 | |
| morphology and function of liver after intravenous and intraportal injections of the immunomodulating agent propionibacterium granulosum. | an immunomodulator, cell walls from propionibacterium granulosum strain kp-45 (pg), has been applied in rabbits to test its influence on morphology and function of liver cells. for investigation of distribution in internal organs, the pg preparation was 51cr-labelled and injected i.v. into mice. functional liver tests were performed in rabbits injected intravenously or intraportally with pg. morphologic studies (light and electron microscopy) of liver sections were performed in mice and rats inj ... | 1984 | 6542531 |
| immunochemotherapy of breast cancer with propionibacterium granulosum. | eighty-two patients with metastatic breast cancer were treated with adriamycin, cyclophosphamide, and 5-fluorouracil (fac). these patients were divided by randomization into two groups. one was receiving cytostatic drugs only, while another received the identical cytostatic medication plus additional therapy consisting of iv infusions of gamma-radiation-sterilized cells of propionibacterium granulosum strain kp-45. metastases were localized in six different sites and/or organs. multiple paramete ... | 1983 | 6553504 |
| inhibition of lewis lung carcinoma in mice by local microwave hyperthermia combined with immunomodulating propionibacterium granulosum kp-45. | c-57 bl/6 mice with lewis lung carcinoma were treated 2 weeks after tumor implantation with local microwave hyperthermia (2450 mhz, tumor temperature 43.5 degrees c, 30 min) and/or intratumoral or intraperitoneal injection of 1 mg cell walls of propionibacterium granulosum kp-45. tumor growth, survival time of the animals, and the delayed skin hypersensitivity to oxazolone were followed up, as well as the 3h-thymidine uptake of tumorous tissues and the number of lung metastases. the combined tre ... | 1984 | 6561066 |
| effects of oxygen concentration on biomass production, maximum specific growth rate and extracellular enzyme production by three species of cutaneous propionibacteria grown in continuous culture. | propionibacterium acnes, propionibacterium avidum and propionibacterium granulosum were grown in continuous culture at 0-100% air saturation using a semi-synthetic medium. maximum specific growth rate, biomass concentration and extracellular lipase, hyaluronate lyase and phosphatase activities were determined. all three species were capable of growth at 100% air saturation but at reduced growth rates. the presence of oxygen altered the production of extra-cellular enzymes. propionibacterium avid ... | 1983 | 6663280 |
| effect of immunostimulation with the corynebacterium granulosum derived immunomodulator p40 on patients with recurring respiratory infections. | 1984 | 6706894 | |
| immunomodulation by propionibacterium granulosum kp 45 and experimental trichinellosis in mice. | swiss mice were infected orally with 200 trichinella spiralis larvae and injected intraperitoneally with a potent immunomodulator (isolated cell walls of propionibacterium granulosum strain kp 45). in control mice 22 871 +/- 9913 larvae were found in the whole body, whereas in mice treated with p. granulosum kp 45 on the day of inoculation 9450 larvae +/- 8244 larvae were counted (p less than 0.01). immunomodulation 7 days before or 7 days after t. spiralis inoculation gave less pronounced effec ... | 1984 | 6741346 |
| dispersal of non-sporeforming anaerobic bacteria from the skin. | dispersal of non-sporeforming anaerobic bacteria was studied. skin samples were taken from the subjects, and dispersed from different parts of the body was examined. the number of anaerobic bacteria dispersed was not correlated to their density on the surface of skin area exposed. the highest density of anaerobic bacteria on the skin was found in the face and upper trunk, but the highest yield of anaerobic bacteria dispersed came from the lower trunk. the dominant anaerobic bacteria dispersed we ... | 1982 | 6806353 |
| isolation, identification, and synthesis of 2,3-diamino-2,3-dideoxyglucuronic acid: a component of propionibacterium acnes cell wall polysaccharide. | a previously undescribed component of the cell wall polysaccharide of propionibacterium acnes, 2,3-diamino-2,3-dideoxyglucuronic acid, has been identified and synthesized. the component occurs to the extent of about 3 to 5% in the wall polysaccharides of p. acnes types i and ii and in propionibacterium avidum types i and ii; it also appears to be present, but in much smaller amounts, in the cell wall of propionibacterium granulosum. | 1983 | 6826525 |
| a 2.5-year follow-up of local immunotherapy of advanced stomach and intestinal adenocarcinoma with propionibacterium granulosum. | intratumoral injections of 10 mg cells walls from propionibacterium granulosum strain kp-45 (pg) were applied in 14 patients with advanced, metastatic stomach (five cases) and colorectal (nine cases) adenocarcinoma. each patient had his own "twin" control. all patients received no other anticancer treatment, except analgetics and/or palliative surgery. treatment with pg resulted in partial regression of tumors accompanied by improvement of the clinical state of these patients as well as the reap ... | 1983 | 6833344 |
| local immunotherapy of stomach and intestinal carcinoma by propionibacterium granulosum. | the effect of cell suspension of propionibacterium granulosum strain kp-45 injected intratumorally was estimated in patients with advanced malignant neoplastic disease of the upper and lower part of the digestive tract. these patients received no other anticancer treatment, and results of therapy with p. granulosum were compared with a control group of nontreated patients. in the course of immunotherapy, general clinical state, dynamics of tumor growth as judged by endoscopy and morphologic, bio ... | 1980 | 6970114 |
| macrophage and t lymphocyte content of tumors in mice treated with propionibacterium. | macrophage and t lymphocyte content of sarcoma tumors in mice treated with propionibacterium granulosum (pg) by different routes was investigated and compared with the effectiveness of the therapy. two different methods for tumor macrophage detection, the fc receptor analysis and phagocytic properties, were employed. indirect fluorescent staining of theta-antigen on lymphocytes was used to evaluate the proportion of tumor t cells. systemic treatment with pg appeared to be effective if given soon ... | 1981 | 6975454 |
| [local immunomodulation in advanced crohn disease with a cell-wall preparation of propionibacterium granulosum kp-45]. | four patients aged 30-34 years with crohn's disease in and advanced stage, having lasted 2 or 3 years, were treated by several injections of 10mg lyophilized cell wall material of p. granulosum strain kp-45 locally into the lesion. in all 4 cases a preceding conventional therapy with salazopyrine and prednisone or surgery had been unsuccessful. this local immunomodulatory treatment led to decisive improvement of the disease in all 4 cases, in 3 cases inflammatory symptoms disappeared completely. ... | 1982 | 6985153 |
| effect of clindamycin, erythromycin, lincomycin, and tetracycline on growth and extracellular lipase production by propionibacteria in vitro. | two propionibacteria identified as propionibacterium acnes and propionibacterium granulosum were grown anaerobically in the presence of growth subinhibitory concentrations (0.25 and 0.5 minimal inhibitory concentrations) of clindamycin, erythromycin, lincomycin, and tetracycline. viable counts and assays of extracellular lipase were performed on samples taken at 24-h intervals over a 96-h period. the results showed that lincomycin and clindamycin could inhibit the production of the enzyme by bot ... | 1982 | 7081974 |
| immunological investigation and immunotherapy in patients operated on for breast carcinoma. | the tumor-host relationship is an essential factor in the onset, development, and recovery from malignancies. a basic consideration in the treatment of cancer patients must therefore be to understand this relationship and attempt to modify it in order to favor the host. we here discuss the results of a study of the immunologic status of 91 breast cancer patients. the use of a battery of tests with five subcutaneous hypersensitivity antigens allowed us to detect some differences in the immunologi ... | 1982 | 7095998 |
| immunomodulation with p40, an insoluble delipidated fraction of corynebacterium granulosum. i.--immune response to sheep red blood cells. | the immunological responses to sheep red blood cells (srbc) were evaluated in mice in order to study the immunomodulating effects of an insoluble fraction of corynebacterium granulosum, designated p40. a single intravenous (iv) injection of 50 micrograms or more of p40 was able to stimulate the reticulo-endothelial system, as measured by the spleen index. a single iv injection of 250 micrograms of p40, given seven days prior to iv sensitization of groups of mice with varying doses of srbc, was a ... | 1982 | 7149642 |
| immunomodulation with p40, an insoluble delipidated fraction of corynebacterium granulosum. ii.--specific immune responses of the host. | mice immunized subcutaneously in the footpad with p40, an insoluble fraction extracted from delipidated heat-killed corynebacterium granulosum, developed systemic mechanisms which depended on the generation of a state of systemic cellular hypersensitivity to p40 antigens. an injection of p40 into the footpad resulted in a striking increase in cell division in the draining lymph node, the development of a state of specific systemic delayed type hypersensitivity and a systemic increase in the bact ... | 1982 | 7149643 |
| protection and therapy of mice with acute and chronic experimental virus infections with propionibacterium granulosum kp-45. | the protection of mice against experimental infections with three different viruses (herpes simplex, vaccinia and mouse hepatitis) by propionibacterium granulosum strain kp-45 and isolated cell walls was investigated. pretreatment of nmri mice with p. granulosum strain kp-45 3-7 days prior to hsv intranasal infection resulted in lowering of mortality rate (herpes encephalitis) from about 95% in controls to 15-30%. pretreatment of nmri mice prior to vaccinia virus infection also caused a signific ... | 1980 | 7223126 |
| postirradiation recovery of hemopoiesis in mice treated with propionibacterium granulosum. | the effect of propionibacterium granulosum on spontaneous regeneration of hemopoiesis in nonlethally (250 or 400 rads) irradiated mice was investigated and measured by peripheral blood leukocyte counts each 2 days after irradiation and incorporation of 3h-thymidine into spleen and thymus in vivo. p. granulosum injected intraperitoneally in a dose of 1.5 mg per mouse, 7 days before or 4 days after irradiation, resulted in accelerated recovery of hemopoiesis after nonlethal irradiation with signif ... | 1981 | 7250296 |
| isolation and significance of anaerobic bacteria isolated from cases of bovine mastitis. | the role of obligate anaerobic bacteria in the aetiology of mastitis of lactating dairy cows was investigated. anaerobes were isolated from 12% of lactating mastitic cows, which were representative of 50% of the 10 dairy herds examined. bacteroides fragilis was the most frequently isolated organism of (50%), followed by peptococcus indolicus (33%), eubacterium lentum (33%), e. aerofaciens (17%), propionibacterium granulosum (17%) and an anaerobic streptococcus sp. (17%). these obligate anaerobes ... | 1981 | 7312305 |
| [immunotherapy of chronic hepatitis b with bacterial preparations (propionibacterium granulosum kp-45)]. | 1981 | 7330245 | |
| effects of glucose concentration n biomass, maximum specific growth rate and extracellular enzyme production by three species of cutaneous propionibacteria grown in continuous culture. | there cutaneous propionibacteria - propionibacterium acnes, p. avidum and p. granulosum - were grown in chemostats using semi-synthetic medium with various concentrations of glucose. biomass rose with increasing glucose concentration up to 0.3-0.4% (w/v) and then remained constant. propionibacterium granulosum had both a low yield and low mumax when grown in the absence of glucose suggesting that this organism is essentially 'saccharolytic' in its nutrition. in contrast, p. acnes and p. avidum h ... | 1981 | 7343643 |
| immunostimulation by systemic administration of propionibacterium granulosum in patients with primary or secondary lung tumours. | the effect of a cell suspension of propionibacterium granulosum strain kp-45 given intravenously to patients with advanced primary or secondary lung carcinoma, and simultaneously treated with cytostatic drugs, was estimated. the control group consisted of patients treated with cytostatics only. the clinical state of patients treated with the kp-45 preparation and with this immunostimulant plus cytostatics, was compared by evaluation of tumour size by x-ray examination, peripheral blood picture, ... | 1981 | 7347693 |
| [case of rectal adenocarcinoma treated by immunostimulation with corynebacterium granulosum]. | 1980 | 7405218 | |
| the in vivo cytostatic effect induced by propionibacterium granulosum on murine tumor cells. | the cytostatic action of propionibacterium granulosum was studied in a mouse sarcoma in vivo. kinetic analysis of tumor cells 28 days after tumor implantation and systemic immunotherapy showed that the cell cycle time was identical in both treated and untreated tumors. p. granulosum treatment resulted in a marked prolongation of the s phase and shortening of the g1 phase of the cell cycle. a pronounced drop in the number of labeled interphases and the reduction of the growth fraction were observ ... | 1980 | 7451553 |
| new medium for isolating propionibacteria and its application to assay of normal flora of human facial skin. | the conditions for isolation and cultivation of propionibacterium acnes and related propionibacteria were studied in detail. triton x-100 added to the diluent inhibited the growth of propionibacteria in concentrations of 0.05 to 0.1%. however, such was not the case with tween 80; rather, growth of the bacteria was further enhanced by this agent. consequently, tween 80 was considered to be a suitable surfactant for addition to the diluent for isolation of propionibacteria. a new medium for isolat ... | 1980 | 7470244 |
| comparative effects of different strains of corynebacterium parvum on natural cell-mediated cytotoxicity. | because there are conflicting reports regarding the effects of corynebacterium parvum (cp) on natural killer (nk) cell activity, several different strains of cp were compared. in replicate experiments, age- and sex-matched mice received 0.25-mg i.p. injections of one of four types of cp; formalin-killed strain 6134; heat-killed strain 6134; formalin-killed strain 5888 (actually corynebacterium granulosum); or formalin-killed cp from the pasteur institute. at various days thereafter, two to three ... | 1980 | 7471057 |
| [selective problems from catamnestic studies of sspe patients (1980-1989)]. | the analysis of disease courses and survival times of 132 cases of sspe treated by various methods in the i department of neurology, institute of psychiatry and neurology, in years 1980-1989 is reported. follow-up data were obtained during control examinations of patients or from an inquiry answered by parents or doctors at the place of residence of the patients. in the treatment all patients were given immunomodulating drugs. about 25% of the patients were treated with isoprinosine, in the rema ... | 1994 | 7520551 |
| [changes of cognitive and emotional processes during immunostimulatory treatment in subacute sclerosing panencephalitis]. | in 35 cases of sspe sensibilized neuropsychological testing was done before and after 6 months of immunostimulatory and virostatic treatment. three groups of patients were studied. all groups received isoprinosine, one group was given additionally tfx-thymus extract polfa, and another group received additionally propionibacterium granulosum kp-45. a tendency for improvement of verbal function and emotional status was observed only in the group receiving isoprinosine with propionibacterium. in bo ... | 1993 | 7684827 |
| in vitro modulation of keratinocyte-derived interleukin-1 alpha (il-1 alpha) and peripheral blood mononuclear cell-derived il-1 beta release in response to cutaneous commensal microorganisms. | the ability of a range of skin commensal microorganisms to modulate interleukin-1 (il-1) release by cultured human keratinocytes and peripheral blood mononuclear cells (pbmcs) was investigated by a combination of enzyme-linked immunosorbent assays and bioassays. three fractions (formaldehyde-treated whole cells, culture supernatants, and cellular fractions) were prepared from propionibacterium acnes, propionibacterium granulosum, staphylococcus epidermidis, staphylococcus capitis, staphylococcus ... | 1995 | 7890376 |
| preoperative immunostimulation by propionibacterium granulosum kp-45 in colorectal cancer. | in order to improve the perioperative resistance to the spread of cancer during operation the effect of preoperative stimulation of the immunesystem by propionibacterium granulosum kp-45 was investigated in patients with colorectal carcinoma. in a prospective randomized trial 101 patients were allocated to either treatment (n = 51) or control (n = 50). in the treatment 10 mg of propioni bacteria were administered intravenously between the seventh and third day prior to surgical treatment. at the ... | 1994 | 8067712 |
| immunostimulation by propionibacteria--effects on immune status and antineoplastic treatment. | experimental studies were performed to investigate further the effects of immunotherapy with propionibacterium avidum kp-40 on thymocyte proliferation, maturation and emigration in balb/c-mice. thymus weight and thymocyte counts, especially cells presenting the immature or cytotoxic/suppressor phenotype were significantly increased. due to enhanced emigration, peripheral blood lymphocyte and monocyte counts as well as expression of activation markers were significantly upregulated. the antimetas ... | 1995 | 8572653 |
| propionibacterium granulosum activities in rats during the muscle phase of trichinella spiralis invasion. | immune response of wistar rats, infected with 4000 l1 t. spiralis and treated with p. granulosum during the muscle phase of nematode invasion were measured. the increase of spleen mass was observed in all groups infected and exposed to p. granulosum. intraperitoneal injection of bacteria results in higher level of t lymphocytes and activated neutrophils. the level of inhibition of macrophages migration was depended on relation to the time and doses of injection. in non-specific stimulated animal ... | 1996 | 8755145 |
| oral administration of a bacterial immunomodulator enhances the immune response to cholera toxin. | attempts to achieve iga responses in the intestine by oral immunization with non replicating antigens have been characterized by ineffective responses of short duration unless long term dosages are administered. cholera toxin (ct) is an exception in that it is able to produce a high secretory and systemic immune response. we study the effects of a bacterial immunomodulator [3 x 10(10) propionibacterium granulosum ml-1 and lipopolysaccharide (lps) 5 mg ml-1] on the immune response to ct orally ad ... | 1996 | 8911015 |
| endocarditis due to propionibacterium granulosum. | 1996 | 8922825 | |
| omeprazole induces altered bile acid metabolism. | it has been reported that the acidity of gastric contents could be an important factor in regulating jejunal flora. | 1998 | 9536953 |
| subgingival microbiota of shallow periodontal pockets in individuals after head and neck irradiation. | this study aimed at investigating the subgingival plaque microorganisms of shallow pockets (< or = 5 mm) in subjects who previously received irradiation in the head and neck region for treatment of nasopharyngeal carcinoma. direct microscopy and anaerobic culture were used. subgingival paper point samples were taken from 6 tooth-sites (one/sextant) per subject for direct microscopy (n = 108). another set of paper points was taken from the deepest of the previously selected sites (one per subject ... | 1998 | 9573815 |
| [the evaluation of the use of antineoplaston as2-1 treatment in subacute sclerosing panencephalitis]. | a follow-up study was carried out of 16 sspe patients two years after completion of 6-month treatment with antineoplaston. the study was based on an inquiry sent to the families of the patients and on control examinations at the clinic. in the period of follow-up 6 patients died, all had the downhill type of disease course and their mean survival was 18 months. out of the remaining 10 patients 4 are in stationary condition and the remaining ones had minimal worsening. a more detailed clinical an ... | 1999 | 10612094 |
| in vitro and in vivo effects of an immunomodulator composed of escherichia coli lipopolysaccharide and propionibacterium granulosum-inactivated cells in pigs. | the in vitro cytokine profiles of porcine alveolar macrophages and peripheral blood mononuclear cells (pbmc) were examined by reverse transcription-polymerase chain reaction or enzyme-linked immunosorbent assay after stimulation with the immunomodulatory compound inmd [lipopolysaccharide (lps) and propionibacterium granulosum]. expression of interleukin-1 (il-1), il-6, il-12 and tumour necrosis factor-alpha (tnf-alpha), but not of il-10, was detected in inmd-stimulated alveolar macrophages. stim ... | 2000 | 11075550 |
| propionibacterium granulosum: a rare cause of endocarditis. | 2000 | 11120624 | |
| quantitative analysis of mycobacterial and propionibacterial dna in lymph nodes of japanese and european patients with sarcoidosis. | the cause(s) of sarcoidosis is unknown. mycobacterium spp. are suspected in europe and propionibacterium spp. are suspected in japan. the present international collaboration evaluated the possible etiological links between sarcoidosis and the suspected bacterial species. formalin-fixed and paraffin-embedded sections of biopsy samples of lymph nodes, one from each of 108 patients with sarcoidosis and 65 patients with tuberculosis, together with 86 control samples, were collected from two institut ... | 2002 | 11773116 |
| minocycline effectively reduces acid producted by propionibacterium granulosum. | we studied the effects of minocycline on propionibacterium granulosum. p. granulosum lipase activity was detected from acne lesions. production of propionic and butyric acids by p. granulosum was well suppressed by all tested media with added minocycline; the higher the concentration of minocycline in the medium, the less of these acids was produced. it appeared that the decrease in these acids due to minocycline was greater in p. granulosum than in p. acnes. although the influence of p. granulo ... | 2002 | 11837569 |