Publications

dna of avian myeloblastosis-associated virus type 2 integrates at multiple sites in the chicken genome.	the cellular sites of integration of the avian myeloblastosis-associated virus type 2 (mav-2) dna have been examined by southern blot analysis of cellular dna from infected cloned and uncloned chicken embryonic fibroblasts. provirus-cell juncture fragments were not detected in restriction enzyme digests of dna from mav-2-infected uncloned cells. however, each mav-2-infected cell clone examined produced a unique set of junctive bands. thse findings indicate that multiple sites of integration exis ...	1980	6252351
identification of potential human oncogenes by mapping the common viral integration sites in avian nephroblastoma.	gene deregulation is a frequent cause of malignant transformation. alteration of the gene structure and/or expression leading to cellular transformation and tumor growth can be experimentally achieved by insertion of the retroviral genome into the host dna. retrovirus-containing host loci found repeatedly in clonal tumors are called common viral integration sites (cvis). cvis are located in genes or chromosomal regions whose alterations participate in cellular transformation. here, we present th ...	2006	16397219