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[incorporation of radioactivity from 2-cl4 na-acetate into the volatile oil of achillea millefolium l. biosynthesis of certain terpene components]. 1977920193
thin layer and gas-chromatographic studies on the essential oil from achillea millefolium. 19751161905
isolation and identification of three new flavones from achillea millefolium l.column chromatography on silica gel of a petroleum ether extract of the flowering heads of achillea millefolium l. allowed three flavones to be separated and identified. spectral studies (pmr, mass spectrometry, and uv) and a comparison with data for compounds reported in the literature established the flavones as 5-hydroxy-3,6,7,4'-tetramethoxyflavone, artemetin, and casticin. these compounds have not been reported previously as constituents of a. millefolium.19751195115
prehibernation diet and reproductive condition of female anopheles messeae in sweden.1. blood and sugar feeding in the mosquito anopheles messeae falleroni were investigated near uppsala, sweden, from 1981 to 1985, with emphasis on prehibernation diet. 2. fructose, indicating plant feeding, was present in females of all ovarian stages, from april to october, and contributed to fat body development in non-gonoactive females before hibernation. 3. an.messeae males and females (inseminated and uninseminated) were observed feeding on floral nectaries of the plants achillea millefoli ...19911768915
[sesquiterpenelactones of achillea setacea with antiphlogistic activity].from the aerial parts of achillea setacea w. & k. (asteraceae) the main sesquiterpenes were isolated. their structures were determined by means of 2d-nmr and ms as 11,13-dehydrodeacetylmatricarin (1) (= 14-deoxylactucin), rupicolin a (2), and rupicolin b (3). these are the first compounds with an alpha-methylene-gamma-lactone structure isolated from a species belonging to the achillea millefolium aggregate. achillicin, achillin, 8-hydroxyachillin, 8-acetoxyachillin, and matricin could not be det ...19911798798
[peroxides as plant constituents. 8. guaianolide-peroxides from yarrow,achillea millefolium l., a soluble component causing yarrow dermatitis].from the ether extract of the blossoms of yarrow, achillea millefolium l., two guaianolides (1, 2) with a peroxide bridged cyclopentane ring and an alpha-methylene-gamma-butyrolactone structure have been isolated. for these compounds the names alpha-peroxyachifolid (1) and beta-peroxyisoachifolid (2) are proposed. 1 is responsible for the allergic contact dermatitis caused by yarrow.19911815484
alpha-peroxyachifolid and other new sensitizing sesquiterpene lactones from yarrow (achillea millefolium l., compositae).yarrow, achillea millefolium l., is one of the commonest weeds of the compositae family. cases of allergic contact dermatitis have been described since 1899. although 10 sesquiterpene lactones (sl) and 3 polyines have previously been identified, the sensitizers of yarrow have escaped detection. a reinvestigation of short ether extracts of yarrow revealed the presence of 5 unsaturated hitherto unknown guaianolides of peroxide character. the main sl, identified as a strong sensitizer in guinea pig ...19911868717
[experience in treating digestive organ diseases with medicinal plants].results are reported of treatment of chronic hyposecretory gastritis, chronic hepatocholecystitis and angiocholitis by a herbal complex. the herbal composition included achillea millefolium, urtica dioica, cichorium (aboveground part), polygonum, matricaria chamomilla (flowers), helichrysum arenarium, calendula (flowers), corn stigmas, humulus lupulus (racemes) in proportion 3:3:1:1:2:1:1:2:1 respectively. the herbal decoction is to be taken 3 times daily before meals. diet n 5 (pevzner scheme) ...20092750130
[study of azulen in 3 subspecies of achillea millefolium l]. 19883214101
effect of cadmium on germination, growth and active principle contents of achillea millefolium l.the effects on germination, growth and active principle contents of achillea millefolium l. of an increase of cadmium concentration in soil and in atmosphere were investigated. soil pollution reduced germination and growth. no significant differences were found in glc analysis of all plants extracts.19883247344
high-performance liquid chromatographic characterization of some medical plant extracts used in cosmetic formulas.rapid and reliable methods are presented for the characterization of biologically active and/or characteristic constituents in aqueous extracts of hamamelis virginiana, matricaria chamomilla, achillea millefolium, thymus vulgaris, althaea officinalis and cinchonia spp. prior to high-performance liquid chromatographic (hplc) separation a clean-up step was performed using a solid-phase extraction system. the purified extracts were analysed by hplc coupled with a diode-array detector and a fluoresc ...19883417826
isolation of the anti-inflammatory principles from achillea millefolium (compositae). 19694310133
phytopharmacologic studies of achillea millefolium linn. 19744443016
the constituents of the essential oil from achillea millefolium l. 19744449407
[achillea collina becker--a proazulene containing taxon from achillea millefolium l.s.l]. 19685703899
gas chromatographic analysis of the essential oil from achillea millefolium l. 19685708362
[on the content of etheric oils, azulene and bitter principle in selected clones of achillea millefolium l. s.l]. 19695821952
[determination of azulene in the oil of milfoil (achillea millefolium) by thin-layer chromatography]. 19655853287
uptake of 2,4-d in higher plants from artificial rain.sinapis alba l., lapsana communis l., achillea millefolium l., brassica napus l., lactuca sativa l., and lycopersicum esculentum l. were exposed to 2,4-dichlorophenoxy [2-14c]acetic acid (2,4-d) at 10 micrograms liter-1 in artificial rain, ph 6.5 and 3.3. the 2,4-d was absorbed in all species tested. concentrations of parent 2,4-d appeared at the highest level in achillea (0.1 mg kg-1 dry wt), and at zero level in lycopersicum. twenty-one daily treatments at ph 6.5 for 30-min periods increased d ...19846428858
herbal remedies of the maritime indians: sterols and triterpenes of achillea millefolium l. (yarrow).as part of ongoing studies of the medicinal aspects of maritime flora, particularly the herbal remedies of the micmac and malecite indians, the sterols and triterpenes of achillea millefolium l. (compositae), a widely used herbal remedy known commonly as yarrow, were determined. using modern techniques, including nuclear magnetic resonance spectroscopy and combined gc-mass spectrometry, beta-sitosterol was identified as the major sterol and alpha-amyrin as the major triterpene of this plant. the ...19827097536
novel antitumor sesquiterpenoids in achillea millefolium.three new antitumor sesquiterpenoids, achimillic acids a, b and c, were isolated as methyl esters from achillea millefolium and their structures were determined spectroscopically. the compounds were found to be active against mouse p-388 leukemia cells in vivo.19948069962
[quantitative determination of alpha-peroxyachifolide in yarrow by hplc with amperometric detection].a hplc method with amperometric detection is established for the contact allergen alpha-peroxyachifolid (1) from yarrow (achillea millefolium l., s. str.). the amounts of 1 are between 0.25 and 0.60% in blossoms, dried 2 h at room temperature, and between 0.01 and 0.05% in the leaves. in completely dried material and in some preparations from the market 1 could also be quantified.20078171079
genotoxicity testing of different types of beverages in the drosophila wing somatic mutation and recombination test.five wines and one brandy of spanish origin as well as three herbal teas and ordinary black tea were tested for genotoxicity in the wing somatic mutation and recombination test (smart) which makes use of the two recessive wing cell markers multiple wing hairs (mwh) and flare (flr3) on the left arm of chromosome 3 of drosophila melanogaster. 3-day-old larvae trans-heterozygous for these two markers were fed the beverages at different concentrations and for different feeding periods using drosophi ...19948206441
antispermatogenic effect of achillea millefolium l. in mice.the effect of an ethanolic extract (200 mg/kg/day, intraperitoneally, for 20 days) and a hydroalcoholic extract (300 mg/kg/day, orally, for 30 days) of achillea millefolium l. (yarrow) flowers on the spermatogenesis of swiss mice was studied by evaluating morphologic characteristics with the light and electron microscopes. the alterations observed were exfoliation of immature germ cells, germ cell necrosis, and seminiferous tubule vacuolization. animals treated with the extracts had an increased ...19989883387
attraction of culex pipiens pipiens (diptera: culicidae) to flower volatiles.methylene chloride extracts of flowers from 4 plants (common milkweed, asclepias syriaca l; ox-eye daisy, leucanthemum vulgare lamarck; canada goldenrod, solidago canadensis l.; and yarrow, achillea millefolium l.) were tested in a dual-port olfactometer for attractiveness to female northern house mosquitoes, culex pipiens pipiens l. fifty milligrams of extract was used for each test, which was equivalent to the amount of extract from flowers of 0.58 common milkweed inflorescences, 1.75 ox-eye d ...199910467780
t-lymphocyte cytokine profiles in compositae airborne dermatitis.compositae airborne dermatitis is a well-recognized disorder characterized by erythematosquamous lesions and papules on light-exposed areas. the presence of positive patch test reactions and the absence of specific serum ige suggest delayed-type hypersensitivity, the murine model of which is characterized by a th1 cytokine production profile [high amounts of interferon (ifn)-gamma and interleukin (il)-2; little or no il-4 and il-5]. the aim of this study was to evaluate the cytokine profile of t ...199910583117
[the use of preparations of plant origin in treating and rehabilitating elderly patients with chronic hepatitis].the article contains data on use of vegetal drugs hepatofalk planta, chicory, achillea millefolium in the treatment and rehabilitation of chronic hepatitis in elderly subjects.201610672726
[enantiomeric monoterpenes in ether oil from achillea millefolium s. i.--a taxonomically useful marker?].the achillea millefolium complex is a group of taxonomically hardly separable species. yarrow has the tendency to hybridize and to vary in phenotype. an obvious characterization of the species or hybrids is not just important for the taxonomical distinction but also for a reliable assessment of herbal drug quality. most of the achillea plants are still gathered from natural populations. according to the variation in phenotype, mixtures with achillea species, which contain allergy setting compoun ...200010907256
solid-phase microextraction of volatile components from natural grassland plants.the volatile components from nine plants growing on natural grasslands in auvergne, central france, selected for the broad qualitative and quantitative diversity of their terpenoid fractions, were analyzed by high-resolution gas-phase chromatography and mass spectrometry (hrgc-ms) after static headspace solid-phase microextraction (shs-spme). shs-spme allowed all the plant material to be analyzed under the same conditions despite its wide-ranging composition. this is not always possible with oth ...200111170578
effect of 'antidiabetis' herbal preparation on serum glucose and fructosamine in nod mice.the antihyperglycemic effect of the antidiabetis herbal preparation ((myrtilli folium (vaccinium myrtillus l.), taraxaci radix (taraxacum officinale web.), cichorii radix (cichorium intybus l.), juniperi fructus (juniperus communis l.), centaurii herba (centaurium umbellatum gilib.), phaseoli pericarpium (phaseolus vulgaris), millefollii herba (achillea millefolium l.), morii folium (morus nigra l.), valeriane radix (valleriana officinalis l.), urticae herba et radix (urtica dioica l.)), patent ...200111297848
production of yarrow (achillea millefolium l.) in norway: essential oil content and quality.in 1996, the production of achillea millefolium l. at different locations in norway was investigated with regard to the developmental stage. the oil content differed greatly between the vegetative stage (0.13%) and the stage of full bloom (0.34%). changes in the composition of yarrow essential oil were found to be related to maturation of the plant, with increasing amounts of monoterpenes in relation to the sesquiterpene. however, a clear trend could be detected only for the monoterpenic compoun ...200011312793
final report on the safety assessment of yarrow (achillea millefolium) extract.yarrow (achillea millefolium) extract is an extract of the yarrow plant, achillea millefolium, supplied in polypropylene glycol, which is reported to function as a "biological additive" in cosmetic products. sesquiterpene lactones, polyacetylenes, simple coumarins, and flavonoids have been identified among the many components of a. millefolium. yarrow extract was reportedly used in 65 cosmetic formulations. historically, yarrow (achillea millefolium) extract was reported to be used at concentrat ...200111558643
in vitro anti-hepatoma activity of fifteen natural medicines from canada.fifteen crude drugs, stellaria media cyrill. (caryophyllaceae), calendula officinalis l. (compositae), achillea millefolium l. (compositae), verbascum thapsus l. (scrophulariaceae), plantago major l. (plantaginaceae), borago officinalis l. (boraginaceae), satureja hortensis l. (labiatae), coptis groenlandica salisb. (ranunculaceae), cassia angustifolia vahl. (leguminosae), origanum majorana l. (labiatae), centella asiatica l. (umbelliferae), caulophyllum thalictroides mich. (berberidaceae), pice ...200212203264
screening of some plants used in the brazilian folk medicine for the treatment of infectious diseases.extracts of 13 brazilian medicinal plants were screened for their antimicrobial activity against bacteria and yeasts. of these, 10 plant extracts showed varied levels of antibacterial activity. piper regnellii presented a good activity against staphylococus aureus and bacillus subtilis, a moderate activity on pseudomonas aeruginosa, and a weak activity against escherichia coli. punica granatum showed good activity on s. aureus and was inactive against the other standard strains. eugenia uniflora ...200212471432
sesquiterpenes and flavonoid aglycones from a hungarian taxon of the achillea millefolium group.the investigation of a dichloromethane extract of flower heads of a hungarian taxon of the achillea millefolium group led to the isolation of three flavonoid aglycones, one triterpene, one germacranolide and five guaianolides. their structures were elucidated by uv-vis, ei- and ci-ms, 1h nmr and 13c nmr spectroscopic methods as well as by 2d-nmr studies and by selective 1d-noe experiments. besides apigenin, luteolin and centaureidin, beta-sitosterol, 3beta-hydroxy-11alpha,13-dihydro-costunolide, ...200912562079
glutathione s-transferases and malondialdehyde in the liver of nod mice on short-term treatment with plant mixture extract p-9801091.changes in the concentration of glutathione s-transferases (gsts) and malondialdehyde (mda) were assessed in the liver of normal and diabetic nod mice with and without treatment with the plant extract p-9801091. the plant extract p-9801091 is an antihyperglycaemic preparation containing myrtilli folium (vaccinium myrtillus l.), taraxaci radix (taraxacum of fi cinale web.), cichorii radix (cichorium intybus l.), juniperi fructus (juniperus communis l.), centaurii herba (centaurium umbellatum gili ...200312722130
legume presence increases photosynthesis and n concentrations of co-occurring non-fixers but does not modulate their responsiveness to carbon dioxide enrichment.legumes, with the ability to fix atmospheric nitrogen (n), may help alleviate the n limitations thought to constrain plant community response to elevated concentrations of atmospheric carbon dioxide (co(2)). to address this issue we assessed: (1) the effects of the presence of the perennial grassland n(2 )fixer, lupinus perennis, on biomass accumulation and plant n concentrations of nine-species plots of differing plant composition; (2) leaf-level physiology of co-occurring non-fixing species (a ...200312802677
antioxidant and antimicrobial activity of the essential oil and methanol extracts of achillea millefolium subsp. millefolium afan. (asteraceae).the in vitro antimicrobial and antioxidant activities of the essential oil and methanol extracts of achillea millefolium subsp. millefolium afan. (asteraceae) were investigated. gc-ms analysis of the essential oil resulted in the identification of 36 compounds constituting 90.8% of the total oil. eucalyptol, camphor, alpha-terpineol, beta-pinene, and borneol were the principal components comprising 60.7% of the oil. the oil strongly reduced the diphenylpicrylhydrazyl radical (ic(50)=1.56 micro g ...200312860311
tlc and hplc characteristics of desacetylmatricarin, leucodin, achillin and their 8alpha-angeloxy-derivatives.five guaianolides, including two pairs of isomers, from a hungarian taxon of the achillea millefolium group were characterized analytically. different chromatographic systems on tlc and hplc were developed for the analysis of these compounds. tlc of leucodin, 8alpha-angeloxy-leucodin, achillin, 8alpha-angeloxy-achillin and desacetylmatricarin was performed on silica gel using dichloromethaneacetone and cyclohexane-ethylacetate mixtures as mobile phases. hplc on stationary phases as lichrospher r ...200312889533
[proazulene and ethereal oil during various developmental phases of achillea millefolium l]. 195313066066
[genetic or environmental factors with respect to proazulene content of the milfoil achillea millefolium l..]. 195213100056
[content of essential oils in achillea millefolium l..]. 195413231122
[pharmacognostic examination of the prochamazulenogen containing plants achillea millefolium l. and artemisia absinthium l]. 195613388656
[studies on azulene compounds in achillea species. 3. achillea millefolium l. and its different forms in hungary]. 196314203621
[studies on azulene compounds in the genus achillea. 4. components and chemical assessment of achillea millefolium l]. 196414219912
[paper chromatographic comparison of flower heads of matricaria chamomilla l. and of achillea millefolium l]. 195414362498
[contribution to the presence and amount of chamazulene in solitary growing plants of the species achillea millefolium l..]. 195514379238
preliminary screening study of reproductive outcomes after exposure to yarrow in the pregnant rat.yarrow (achillea millefolium) is used for the treatment of diarrhea, as a urinary antiseptic, hypotensive, and diuretic. yarrow also has traditionally been used as an abortifacient, emmenagogue, contraceptive, and for stimulating uterine contractions. for this reason, it is contra-indicated for use in pregnancy. there has, however, been little scientific research carried out to either confirm or refute this recommendation.200314745991
[pharmacognostic research of some species of achillea. note 1. volatile oils analysis].we established the hydrodistilled essential oil yields from the dried flower heads of a. collina j. becker ex reichenb. (collected in austria and romanina), a. millefolium l. (s.l.) (romania) and of three mixtures of some species belonging to the achillea millefolium l. group. constitutents of the essential oils were studied by gc method. the main components of the monoterpene fraction of the oils were 1.8 cineol, camphor, and borneol. the main active principle of the volatile oil, chamazulene, ...201114755993
[achillea millefolium l, the yarrow; morphology and anatomy]. 195014807693
[complementary medicine. achillea millefolium]. 200415233571
possible modulating actions of plant extracts on the chromosome breaking activity of mmc and ara-c in human lymphocytes in vitro.plants popularly used as medicine have been seen as promising natural agents by the pharmaceutical industry. in the present study the action of psidium guajava l. (pg) and achillea millefolium l. (am) infusions on chromosomal aberration formation in human lymphocyte system in vitro was assessed, associating them with the alkylating agent mitomycin c (mmc) and the dna repair inhibitor cytosine-beta-arabin-furanoside (ara-c). the cells were cultivated for 72 h and treated continuously with pg and ...200415251179
reproductive evaluation of aqueous crude extract of achillea millefolium l. (asteraceae) in wistar rats.the present study was conducted to evaluate the toxicity of the exposure to the aqueous extract from leaves (ae) of achillea millefolium l. on reproductive endpoints in wistar rats. adult male rats were treated daily with yarrow extract (0.3, 0.6 and 1.2 g/kg/day) during 90 days by oral gavage. endpoints including reproductive organ weights, sperm and spermatid numbers as well as sperm morphology were evaluated. no clinical signs of toxicity were detected over the treatment period, and body weig ...200415279880
[improvement of diversity, trade and conservation of medicinal and aromatic plants].the significance of medicinal and aromatic plant selection has risen in recent years due to increasing requirements on quality, safety, and efficiency of herbal products. only selected varieties could guaranty the homogeneity of raw material. the chemical diversity of spontaneous populations is one of the main directions of investigations on medicinal and aromatic plants at the institute of botany. the target species under research are following: origanum vulgare, thymus spp., hypericum spp., ac ...200415299985
contact allergy to compositae plants in patients with atopic dermatitis.to investigate the frequency of compositae sensitivity is one of the most important goals of current dermatology and allergology. we have patch tested 30 adult patients suffering from "extrinsic" atopic dermatitis with sesquiterpene lactone mix and compositae mix including compositae mix individual ingredients, extracts of arnica (arnica montana), chamomile (chamomilla recutita), tansy (tanacetum vulgare), fever few (tanacetum parthenium) and yarrow (achillea millefolium) as well as with specifi ...200915503788
anticonflict actions of aqueous extracts of flowers of achillea millefolium l. vary according to the estrous cycle phases in wistar rats.anticonflict-like effects of aqueous extract of flowers of achillea millefolium l., a plant with purported anxiolytic actions, were studied in female wistar rats during late proestrus or diestrus. during late proestrus (p < 0.05), control rats displayed reduced conflict behavior compared with diestrus. diazepam (2.0 mg/kg; i.p.) reduced conflict behavior both during late proestrus (p < 0.05) or diestrus (p < 0.05). doses of 8.0 mg/kg (p < 0.05), 10.0 mg/kg (p < 0.05) or 12.0 mg/kg (p < 0.05) of ...200415597307
[phytochemical investigations regarding the flavonoidic compounds of some species belonging to the achillea millefolium l. group].in this study a qualitative and quantitative analysis of flavonoids from flower heads of achillea species belonging to the a. millefolium l. group was achieved. rutin, apigenin-7-o-glucoside, luteolin-7-o-glucoside in the methanolic extract of a. collina j. becker ex reichenb., a. pratensis saukel et langer, a. millefolium l. were determined by comparison of their rf-tlc data with those obtained from reference flavonoids. apart from flavonoid glycosides, the free aglycones, apigenin and luteolin ...201115688780
chemical variability in the essential oil components of achillea millefolium agg. from different himalayan habitats (india).essential oil diversity was studied in wild achillea millefolium from two different high altitude himalayan habitats (1600 m, 2850 m) and their cultivated populations under uniform environmental conditions at lower altitudes of jammu (300 m). the populations proved to represent two different ecotypes: the 1,8-cineole type and the borneol type with appreciable differences in the contents of oils and mono- and sesquiterpenes. populations from all these habitats showed considerable overlap in vario ...200515770553
treatment of atopic dermatitis with herbal combination of eleutherococcus, achillea millefolium, and lamium album has no advantage over placebo: a double blind, placebo-controlled, randomized trial.to test the efficacy of tri-herbal combination on atopic dermatitis in a randomized, placebo-controlled trial.200515793525
in vitro antimicrobial activity of extracts of four achillea species: the composition of achillea clavennae l. (asteraceae) extract.the extracts of aerial parts of achillea clavennae, achillea holosericea, achillea lingulata and achillea millefolium (hexane:ether:methanol=1:1:1) have been tested for antimicrobial activity in a disk diffusion assay against five bacteria (staphylococcus aureus, escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa and salmonella enteritidis) and two fungi (aspergillus niger and candida albicans). extracts of all four species possessed a broad spectrum of antimicrobial activity agains ...200515978758
analysis of aroma and phenolic components of selected achillea species.dried flowers and leaves of four different achillea species grown wild in several provinces of iran, including one species collected from three different locations of isfahan province were analyzed for the headspace volatile components, total phenolics (tp) and tartaric esters (te). capillary gas chromatography/mass spectrometry (gc/ms) combined with a purge and trap method was used for quantification of aroma components. over 70 compounds were determined in the samples. flower samples from all ...200516021832
the protective effects of achillea l. species native in turkey against h(2)o(2)-induced oxidative damage in human erythrocytes and leucocytes.the aim of the present study was to investigate the protective effects of infusions prepared from 15 achillea (asteraceae) species against h(2)o(2)-induced oxidative damage in human erythrocytes and leucocytes used in traditional turkish medicine. cat, sod and gpx activities, effects of lpo and gsh levels of the infusions on erythrocytes and leucocytes were assessed. the results indicated that all infusions of achillea species were effective on antioxidant enzyme systems of erythrocytes and leuc ...200516118043
evaluation of the inhibitory activities of the extracts of indonesian traditional medicinal plants against plasmodium falciparum and babesia gibsoni.twenty-four kinds of water extracts derived from 22 plants that are traditionally used for the treatment of malaria on java island, indonesia, were screened for their antibabesial and antimalarial activities. among the extracts, 8 extracts displayed strong antimalarial activity, with an inhibition range from 89.6 to 100%, and 15 showed strong antibabesial activity, with an inhibition range from 84.2 to 98.1%. the extracts of achillea millefolium, baeckea frutenscens, brucea javanica, curcuma xan ...200516141673
the efficacy of liv-52 on liver cirrhotic patients: a randomized, double-blind, placebo-controlled first approach.cirrhosis is the irreversible sequel of various disorders that damage liver cells permanently over time. presently, the use of herbal medicines for prevention and control of chronic liver diseases is in the focus of attention for both the physicians and the patients; the reasons for such shift toward the use of herbals include the expensive cost of conventional drugs, adverse drug reactions, and their inefficacy. in the present study, the efficacy of herbal medicine liv-52 (consisting of mandur ...200516194047
growth and nutritive quality of poa pratensis as influenced by ozone and competition.interspecific plant competition has been hypothesized to alter effects of early-season ozone (o3) stress. a phytometer-based approach was utilized to investigate o3 effects on growth and nutritive quality of poa pratensis grown in monoculture and in mixed cultures with four competitor-plant species (anthoxanthum odoratum, achillea millefolium, rumex acetosa and veronica chamaedrys). mesocosms were exposed during april/may 2000-2002 to charcoal-filtered air+25 ppb o3 (control) or non-filtered air ...200616290915
choleretic effects of yarrow (achillea millefolium s.l.) in the isolated perfused rat liver.different species from the achillea millefolium aggregate are used against gastrointestinal and hepato-biliary disorders in traditional european medicine. in this work, a fraction enriched in dicaffeoylquinic acids (dccas) and luteolin-7-o-beta-d-glucuronide was investigated on its choleretic effect in the isolated perfused rat liver (iprl) compared to cynarin (1,3-dcca), the main choleretic compound of cynara scolymus l. a fraction containing 3,4-, 3,5- and 4,5-dcca and luteolin-7-o-beta-d-gluc ...200616303291
in vitro susceptibility of helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders.the gram-negative bacterium helicobacter pylori (hp), identified in 1982, is now recognized as the primary etiological factor associated with the development of gastritis and peptic ulcer disease. in addition, hp infections are also associated with chronic gastritis, gastric carcinoma and primary gastric b-cell lymphoma. for centuries, herbals have been used in traditional medicine to treat a wide range of ailments, including gastrointestinal (gi) disorders such as dyspepsia, gastritis and pepti ...200516317658
physiological and biochemical stress responses in grassland species are influenced by both early-season ozone exposure and interspecific competition.the effects of two-year early season ozone exposure on physiological and biochemical stress response were investigated in model plant communities. achillea millefolium and veronica chamaedrys target plants were grown in monocultures and in mixed cultures with poa pratensis (phytometer) and exposed in open-top chambers over two years for five weeks to charcoal-filtered (cf) air plus 25 nl l(-1) o3 (control) and non-filtered (nf) air plus 50 nl l(-1) o3. significant o3 effects were detected in dif ...200616321463
effect of elevated tropospheric ozone on the structure of bacterial communities inhabiting the rhizosphere of herbaceous plants native to germany.current elevated concentrations of ozone in the atmosphere, as they are observed during summer seasons, can cause severe effects on plant vegetation. this study was initiated to analyze whether ozone-stressed plants also transfer signals below ground and thereby alter the bacterial community composition in their rhizospheres. herbaceous plants, native to germany, with tolerance (anthoxanthum odoratum, achillea millefolium, poa pratensis, rumex acetosa, and veronica chamaedrys) and sensitivity (m ...200516332747
repelling properties of some plant materials on the tick ixodes ricinus l.the repellent effects on nymphal stages of ixodes ricinus l. of some plant materials have been studied in the laboratory. the plant material consisted of an ethanolic extract from achillea millefolium l., and volatile oils of birch and/or pine tar, citronella, cloves, eucalyptus, geranium, lavender, lily of the valley and peppermint. the most pronounced effects were observed for the oils of citronella, cloves and lily of the valley. they possessed repelling activities of the same magnitude as th ...200616360943
the flavonoid casticin has multiple mechanisms of tumor cytotoxicity action.we studied the mechanism of anti-tumor activity of the flavonoid casticin, derived from achillea millefolium. casticin anti-tumor activity results in cell growth arrest in g2/m and in apoptotic death. as a tubulin-binding agent (tba), casticin induces p21, which in turn inhibits cdk1. moreover, casticin appears to down regulate cyclin a. these observations could explain casticin-induced g2/m arrest. following casticin exposure, bcl-2 depletion occurs in cancer cells, and a sub-g1 accumulation oc ...200616387422
evaluation of extracts and oils of mosquito (diptera: culicidae) repellent plants from sweden and guinea-bissau.in laboratory tests, ethyl acetate extracts of hyptis suaveolens poit. from guinea-bissau and rhododendon tomentosum (stokes) h. harmaja (formerly ledum palustre l.) and myrica gale l. significantly reduced probing activity of aedes aegypti (l.). in the field in southern sweden, extracts of leaves of r. tomentosum, m. gale, and achillea millefolium l. significantly reduced biting by aedes mosquitoes. volatile compounds from m. gale, r. tomentosum, a. millefolium, and h. suaveolens were collected ...200616506457
studies on hepatoprotective, antispasmodic and calcium antagonist activities of the aqueous-methanol extract of achillea millefolium.the crude extract of achillea millefolium (am.cr) was studied for its possible hepatoprotective effect against d-galactosamine (d-galn) and lipopolysaccharide (lps) induced hepatitis in mice and antispasmodic effect in isolated gut preparations to rationalize some of the folklore uses. co-administration of d-galn (700 mg/kg) and lps (25 microg/kg) produced 100% mortality in mice. pre-treatment of animals with am.cr (300 mg/kg) reduced the mortality to 40%. co-administration of d-galn (700 mg/kg) ...200616619341
safety and antiulcer efficacy studies of achillea millefolium l. after chronic treatment in wistar rats.achillea millefolium l. (asteraceae), popularly known as yarrow, has been used in folk medicine to treat complaints such as inflammation, pain, wounds, hemorrhages and gastrointestinal disturbances. the aim of the present study was to assess the safety and efficacy of the aqueous extract (ae) of the plant after chronic exposure. indeed, the ae was effective in protecting the gastric mucosa against acute gastric lesions induced by ethanol and indomethacin and in healing chronic gastric lesions in ...200616647233
in vitro estrogenic activity of achillea millefolium l.isolation and biological characterization of pure compounds was used to identify and characterize estrogenic activity and estrogen receptors (er) preference in chemical components of achillea millefolium. this medicinal plant is used in folk medicine as an emmenagogue. in vitro assay, based on recombinant mcf-7 cells, showed estrogenic activity in a crude extract of the aerial parts of a. millefolium. after fractionation of the crude extract with increasing polar solvents, estrogenic activity wa ...200716860978
chamazulene carboxylic acid and matricin: a natural profen and its natural prodrug, identified through similarity to synthetic drug substances.chamazulene carboxylic acid (1) is a natural profen with anti-inflammatory activity and a degradation product of proazulenic sesquiterpene lactones, e.g., matricin. both 1 and proazulenes occur in chamomile (matricaria recutita), yarrow (achillea millefolium), and a few other asteraceae species. it was isolated in improved yields, characterized physicochemically, and found to be an inhibitor of cyclooxygenase-2, but not of cyclooxygenase-1. it had anti-inflammatory activity in several animal mod ...200616872141
occupational asthma from dried flowers of carthamus tinctorious (safflower) and achillea millefolium (yarrow). 200616942580
molecular analysis of arbuscular mycorrhizal fungi colonising a semi-natural grassland along a fertilisation gradient.the community of arbuscular mycorrhizal fungi (amf) colonizing the roots of festuca pratensis and achillea millefolium was characterized in a swedish pasture at different times, along a gradient of fertilization. the small subunit ribosomal rna gene was subjected to pcr and denaturing gradient gel electrophoresis (dgge), sequencing and phylogenetic analysis. the sequences found in this study clustered in 10 discrete sequence groups, seven belonging to glomus, two to scutellospora and one to dive ...200616945098
investigation of the spasmolytic activity of the flavonoid fraction of achillea millefolium s.l. on isolated guinea-pig ilea.the spasmolytic activity of a flavonoid fraction of a commercial sample of yarrow (achillea millefolium s.l.), its main flavonoids as well as quercetin and two flavonoid metabolites were investigated on isolated terminal guinea-pig ilea. the aglycones quercetin, luteolin and apigenin exhibited the highest antispasmodic activities with ic50 values of 7.8 micromol/l, 9.8 micromol/l and 12.5 micromol/l, respectively. rutin and the flavonoid metabolites homoprotocatechuic acid and homovanillic acid ...200617009839
stoichiometric response of nitrogen-fixing and non-fixing dicots to manipulations of co2, nitrogen, and diversity.human activities have resulted in increased nitrogen deposition and atmospheric co(2) concentrations in the biosphere, potentially causing significant changes in many ecological processes. in addition to these ongoing perturbations of the abiotic environment, human-induced losses of biodiversity are also of major concern and may interact in important ways with biogeochemical perturbations to affect ecosystem structure and function. we have evaluated the effects of these perturbations on plant bi ...200717106721
phytochemical analysis of the essential oil of achillea millefolium l. from various european countries.variations in the essential oil composition of achillea millefolium l. growing in estonia and in other european countries, were determined. the oils were obtained in yields of 0.9-9.5 ml kg-1. a total of 102 components were identified. the quantitatively most important components of yarrow were sabinene, beta-pinene, 1,8-cineole, artemisia ketone, linalool, alpha-thujone, beta-thujone, camphor, borneol, fenchyl acetate, bornyl acetate, (e)-beta-caryophyllene, germacrene d, caryophyllene oxide, b ...200617127661
an ethnobotanical study on the usage of wild medicinal herbs from kopaonik mountain (central serbia).an ethnobotanical survey was carried out on the territory of the highest mountain in central serbia, kopaonik, which is characterized by great plant diversity. in total, 83 wild species from 41 families and 96 preparations for use in human therapy were recorded. among those wild plants which are most commonly used for medicinal purposes, hypericum perforatum l., urtica dioica l., achillea millefolium l., matricaria chamomilla l., sambucus nigra l., and thymus serpyllum l. were particularly highl ...200717145148
infrared spectroscopy as a tool for chemotaxonomic investigations within the achillea millefolium group.an ft-ir-based method for the rapid characterization and identification of achillea species was developed. with the ir spectra of the ch2cl2 extracts of a. aspleniifolia, a. collina, a. millefolium, a. millefolium ssp. sudetica, a. pannonica, a. pratensis, a. roseoalba, a. setacea, and a. styriaca, a spectrum library was created. this database allowed the identification of the respective taxa by comparison of ir spectra. moreover, information concerning dominant structural elements of sesquiterp ...200617193212
studies on the origin of (-)-alpha-bisabolol and chamazulene in chamomile preparations; part i. investigations by isotope ratio mass spectrometry (irms).irms was used to determine the delta (13)c-and deltad-values of dried plant material and essential oil fractions of chamomilla recutita and vanillosmopsis erythropappa and of isolated components thereof. both plants turned out to follow the same c (3) photosynthetic pathway. the carbon isotope ratios ( delta (13)c-values) of chamomile-derived bisabolol ranged from -32 per thousando to -30 per thousand; the corresponding deltad-values varied between -240 per thousand and -205 per thousand. vanill ...199017221447
comparative hplc analyses of alkamides within the achillea millefolium group.petrol/et (2)o extractable alkamides from the subterranean parts of different members of the achillea millefolium group were separated and compared by reversed phase hplc. apart from different retention times, each peak could be characterized by its typical uv spectrum obtained by on-line photodiode array detection. based on previously isolated and identified alkamides, a library search program of uv spectra and corresponding retention times was prepared which greatly facilitated a general compa ...199017221454
medicinal plants used in kirklareli province (turkey).in this paper, 126 traditional medicinal plants from kirklareli province in turkey have been reported. one hundred and twenty six plant species belonging to 54 families and among them 100 species were wild and 26 species were cultivated plants. most used families were rosaceae, labiatae, compositae and the most used plants were cotinus coggyria, sambucus ebulus, achillea millefolium subsp. pannonica, hypericum perforatum, matricaria chamomilla var. recutita, melissa officinalis subsp. officinali ...200717257791
ethnoveterinary medicines used for ruminants in british columbia, canada.the use of medicinal plants is an option for livestock farmers who are not allowed to use allopathic drugs under certified organic programs or cannot afford to use allopathic drugs for minor health problems of livestock.200717324258
trypanosoma cruzi: activity of essential oils from achillea millefolium l., syzygium aromaticum l. and ocimum basilicum l. on epimastigotes and trypomastigotes.trypanocidal activity of clove (syzygium aromaticum l.), basil (ocimum basilicum l.) and yarrow (achillea millefolium l.) essential oils and some of their constituents (eugenol and linalool) was investigated on trypanosoma cruzi epimastigote and bloodstream trypomastigote forms. steam distillation was used to isolate the essential oils, with chemical analyses performed by gas chromatography (gc) and gc coupled to mass spectrometry (gc-ms). the ic(50) (concentration that inhibits 50% parasite gro ...200717349626
effects of enhanced uv-b radiation on plant chemistry: nutritional consequences for a specialist and generalist lagomorph.ultraviolet-b (uv-b) radiation has been increasing in temperate latitudes in recent decades and is expected to continue rising for some time. enhanced uv-b radiation can change plant chemistry, yet the effects of these changes on mammalian herbivores are unknown. to examine the influence of enhanced uv-b radiation on nutrition of a specialist and generalist hindgut fermenter, we measured nutritional and chemical constituents of three common north american range plants, big sagebrush (artemisia t ...200717406969
distribution of phenolic compounds in middleeuropean taxa of the achillea millefolium l. aggregate.achillea millefolium l. s.l. is a cytogenetically, morphologically, and chemically polymorphic aggregate. besides the sesquiterpenes that possess chemotaxonomic relevance and mediate the antiphlogistic activity, the plant contains phenolic compounds such as dicaffeoylquinic acids and flavonoids causing choleretic and spasmolytic effects. to evaluate their contribution to the chemotaxonomy of european taxa of the a. millefolium group, we developed a spe-hplc/uv method that allows quantification o ...200717511000
ethnoveterinary medicines used to treat endoparasites and stomach problems in pigs and pets in british columbia, canada.this paper documents the medicinal plants used to treat endoparasites and stomach problems in dogs, cats and pigs in british columbia, canada. ethnoveterinary data was collected over a 6-month period in 2003. the majority of the information on pets came from 2 naturopaths, 10 herbalists, 5 dog trainers, breeders and pet shop owners, 9 holistic veterinarians and 6 of 27 organic farmers. two pig farmers joined the study in the final stages. the following plants were used as anthelmintics: artemisi ...200717628343
achillea millefolium l. s.l. -- is the anti-inflammatory activity mediated by protease inhibition?achillea millefolium l. s.l. is traditionally used not only in the treatment of gastro-intestinal and hepato-biliary disorders, but also as an antiphlogistic drug. as various proteases, for instance human neutrophil elastase (hne) and matrix metalloproteinases (mmp-2 and -9), are associated with the inflammatory process, the aim of this study was to test a crude plant extract in in vitro-protease inhibition assays for understanding the mechanisms of anti-inflammatory action. furthermore, two fra ...200717689902
inhibitory effect of lactone fractions and individual components from three species of the achillea millefolium complex of bulgarian origin on the human neutrophils respiratory burst activity.achillea species are widely used in folk medicine for treatment of inflammatory diseases. the inhibitory effect on the human neutrophils respiratory burst activity of total extracts, their fractions and some main constituents of the flower heads from achillea asplenifolia, a. collina and a. distans belonging to a. millefolium complex of bulgarian origin, were tested by the modified method of tan and berridge. seven from the investigated fractions showed activity similar or higher than that of in ...200717691054
achillea millefolium l. s.l. revisited: recent findings confirm the traditional use.yarrow (achillea millefolium l. s.l.) is traditionally used in the treatment of inflammatory and spasmodic gastro-intestinal disorders, hepato-biliary complaints and inflammation. now we could show that the flavonoids mediated the antispasmodic properties of yarrow, whereas the dicaffeoylquinic acids caused the choleretic effects. moreover, we observed an in vitro-inhibition of human neutrophil elastase, a protease involved in the inflammatory process, by extracts and fractions from yarrow, whic ...200717704978
role of myzus persicae (hemiptera: aphididae) and its secondary hosts in plum pox virus propagation.plum pox virus (family potyviridae, genus potyvirus, ppv) is one of the most important viral pathogens of plants in the genus prunus, particularly prunus persica l. the role of the myzus persicae (sulzer) (hemiptera: aphididae) as a vector of ppv-m, and its role in spreading ppv-m, was investigated. ppv-m-infected peach trees were used as inoculum sources, and transmission to 15 herbaceous species commonly present in and around peach orchards was evaluated. the presence of ppv-m in secondary hos ...200717849850
rapid adaptive divergence in new world achillea, an autopolyploid complex of ecological races.adaptive evolution is often associated with speciation. in plants, however, ecotypic differentiation is common within widespread species, suggesting that climatic and edaphic specialization can outpace cladogenesis and the evolution of postzygotic reproductive isolation. we used cpdna sequence (5 noncoding regions, 3.5 kb) and amplified fragment length polymorphisms (aflps: 4 primer pairs, 1,013 loci) to evaluate the history of ecological differentiation in the north american achillea millefoliu ...200818039326
inhibition of acetylcholinesterase by extracts and constituents from angelica archangelica and geranium sylvaticum.the aim of this study was to explore the acetylcholinesterase (ache) inhibition of several icelandic medicinal herbs. ethanolic extracts of angelica archangelica seeds and the aerial parts of geranium sylvaticum proved effective, with ic50 values of 2.20 mg/ml and 3.56 mg/ml, respectively. the activity of imperatorin and xanthotoxin from a. archangelica was measured. xanthotoxin proved much more potent than imperatorin, with an ic50 value of 155 microg/ml (0.72 mm) but that for imperatorin was a ...201418069242
comparison of capillary electrophoresis and high performance liquid chromatography for determination of flavonoids in achillea millefolium.flavonoids represent an important bioactive component in achillea millefolium. the comparison of the most commonly used analytical methods for the identification and quantification of flavonoids, capillary electrophoresis (ce) and high performance liquid chromatography (hplc), is presented. the methods were optimized and validated. using a 20 mm borate buffer with 30% (v/v) of methanol (ph 9.3) in the ce analysis and a gradient elution with water-acetonitrile mobile phase in the hplc analysis, s ...200818164574
yarrow (achillea millefolium l. s.l.): pharmaceutical quality of commercial samples.yarrow (achillea millefolium l. s.l.) is traditionally used against inflammatory and spasmodic gastrointestinal complaints, hepato-biliary disorders, as an appetite enhancing drug, against skin inflammations and for wound healing due to its antiphlogistic, choleretic and spasmolytic properties. the main pharmacologically active principles were shown to be the essential oil (antimicrobial), proazulenes and other sesquiterpene lactones (antiphlogistic), dicaffeoylquinic acids (choleretic) and flav ...200818271298
uv-b effects on the nutritional chemistry of plants and the responses of a mammalian herbivore.stratospheric ozone depletion has caused ground-level ultraviolet-b (uv-b) radiation to rise in temperate latitudes of both hemispheres. because the effects of enhanced uv-b radiation on the nutrition of food consumed by mammalian herbivores are unknown, we measured nutritional and chemical constituents of 18 forages and related changes to in vitro dry matter digestibility. we also measured intake and in vivo digestibility of pacific willow (salix lasiandra) and alfalfa (medicago sativa l.) by b ...200818274780
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