Publications

retinal capillary basement membrane thickness in spiny mice (acomys cahirinus) with induced and spontaneous diabetes.	basement membrane thickness was measured in two groups of spiny mice (acomys cahirinus): one with spontaneous diabetes, the other with streptozotocin-induced diabetes. a statistical analysis of the morphometric results of the two groups showed a significant basement membrane thickening in the group with induced diabetes when compared to the spontaneously diabetic group.	1975	124711
defective insulin secretion in the spiny mouse (acomys cahirinus). possible value in the study of the pathophysiology of diabetes.		1975	169217
defective early phase insulin release in perifused isolated pancreatic islets of spiny mice (acomys cahirinus).	in order to characterize pancreatic beta cell function in geneva bred spiny mice (acomys cahirinus), the dynamics of immunoreactive insulin release were examined during perifusion of pancreatic islets isolated from normoglycemic acomys. the initial insulin response of acomys was slow: no clear-cut early (1 to 10 min) peak of insulin release was observed when glucose in the perifusion medium was abruptly raised from 2.8 mm to concentrations as high as 56 mm. this was true for islets of either you ...	1975	171800
the metabolism of cyclic amp and glucose in isolated islets from acomys cahirinus.	glucose-induced cyclic (3h) amp accumulation, insulin secretory responses and the metabolism of glucose were studied in pancreatic islets from acomys cahirinus. 27.7 mmol/l of glucose stimulated neither islet cyclic (3h) amp accumulation nor insulin release during the first 5 min of incubation. stimulation by glucose of cyclic (3h) amp was observed after 15 min of incubation and insulin release was markedly stimulated between 15 and 30 min. the utilization of glucose, measured as the production ...	1982	216600
effect of diet-induced obesity on glucose and insulin tolerance of a rodent with a low insulin response (acomys cahirinus).		1979	446935
glucose production by the perfused liver of the spiny mouse (acomys cahirinus): sensitivity to glucagon and insulin.	hepatic glucose production and its responses to glucagon and insulin were studied in perfused livers obtained from spiny mice (acomys cahirinus)--rodents characterized by normoglycemia, decreased glucose tolerance and decreased insulin secretion--and from swiss albino mice. the dose-response characteristics of glucagon-induced hepatic glucose output were similar in spiny and albino mice. however, maximally stimulated glucose production were significantly lower in the spiny mouse. furthermore, th ...	1979	468520
helminths of birds and mammals of israel. viii.- skrjabinocapillaria rodentium n. sp. (nematoda capillariidae) from gerbillid and murid rodents.	skrjabinocapillaria rodentium n.sp., found in the stomach of meriones crassus, gerbillus pyramidum, g. gerbillus, g. dasyurus and acomys cahirinus, is described. it differs from the other two species in the genus, s. bakeri and s. eubursata, mainly in being larger, having a larger number of stichocytes and having a cephalic influation in the female and not in the male.	1979	485042
the reproductive tract of the male spiny mouse (acomys cahirinus) and coagulation studies with other species.	the testes of the spiny mice showed asymmetry, the left being significantly heavier than the right (p = 0.025). histological studies indicated that spermatozoa were first present in the testes of animals 35--45 days of age but the maturation of the accessory glands, especially the lateral prostates and coagulating glands, occurred later. the highest fructose concentration in the adult was in the lateral prostates (126.97 +/- 22.23 mg fructose/100 g, n = 5) and coagulating glands (99.38 +/- 17.65 ...	1979	513000
significance of anomalous thermoregulation in the pre-diabetic spiny mouse (acomys cahirinus): oxygen consumption and temperature regulation.	in keeping with studies of other desert rodents, the potentially diabetic spiny mouse has been demonstrated to have a very low basal metabolic rate, disproportionate to its body weight. the maintenance of a lower body temperature in response to high environmental temperatures and a lack of increase in metabolic rate in response to cooling have also been demonstrated. assessments of "mechanical efficiency" have shown that spiny mice carry a potential selective advantage under fasting conditions. ...	1977	603467
significance of anomalous thermoregulation in the pre-diabetic spiny mouse (acomys cahirinus): cold tolerance: blood glucose and food consumption responses to environmental heat.	decreased cold tolerance, reduced food requirement for body weight maintenance and comparative resistance to the hypoglycaemic effect of fasting in high ambient temperatures have been demonstrated in the spiny mouse. these phenomena could be related to anomalous spiny mouse thermoregulation, a phenomenon which is common in desert rodents and is simulated by mutant and artificially diabetic rodent species. the data can be interpreted as showing evidence for a survival advantage of genotypes with ...	1977	603468
temporal parameters of responsiveness to maternal pheromone in acomys cahirinus.		1978	740774
the verification of neurones in the pancreas of spiny mice (acomys cahirinus).	the statement that up to now no neural elements could be identified in the islets of langerhans with the aid of electron microscopy led us to reinvestigate this question of innervation of the pancreas in spiny mice using light microscopy. single nerve cells as well as nerve fibre bundles could be found in the interlobular connective tissue of the pancreas. by constrast, we could observe neither nerve cells nor nerve fibres in the islets of langerhans. extrainsular neuroinsular complexes could no ...	1976	773639
breeding and reproduction of fifteen wild rodents maintained as laboratory colonies.	data on reproduction and production were presented for laboratory colonies of microtus pennsylvanicus tananaensis, m oeconomus macfarlani, m o operarius, m mirurus, m abbreviatus, lemmus lemmus, l sibiricus trimucronatus, dicrostonyx stevensoni, clethrionomys rutilus, peromyscus maniculatus borealis, p m bairdii, baiomys taylori, calomys ducilla, c callosus, acomys cahirinus. litter size varied from 2.0 in a cahirinus to 5.5 in c callosus. infant (neonatal) and juvenile losses through the end of ...	1976	775192
proinsulin synthesis in islets of langerhans from spiny mice (acomys cahirinus). comparison with rats and mice.	proinsulin synthesis in response to different concentrations of glucose has been studied in islets of langerhans of acomys, rat and mouse. the response to increased glucose was small in acomys when compared with rat or mouse. the time course of the effect of glucose on proinsulin synthesis was also studied in sequential 15 min periods up to 60 min. with 5.5 mm glucose the rate of 3h-leucine incorporation for acomys islets were greater over the periods 15-30, 30-45 and 45-60 min after the additio ...	1976	789163
[the evidence of biogenic amines with reinecke-salt as a new principle of evidence of substances in the ultrahistochemistry (author's transl)].	reinecke-salt (ammonium tetracyanato diamine chromate) is known as amine precipitating reagens in applied chemistry. its amine precipitates can be demonstrated in electron micrographes. the amine reineckates are unable to diffuse and difficult to dissolve. depending from that they are localized in the cells. from our findings received in the boundary layer between adrenal cortex and adrenal medulla, we conclude that there are no non-specific precipitations with other cell components caused by re ...	1975	813480
responses of acomys cahirinus pups to chemical cues produced by a foster species.		1977	901356
maternal pheromone in the spiny mouse (acomys cahirinus).		1976	944929
sex-differences in the agonistic behavior of spiny-mice (acomys cahirinus).	observations of 8 groups each containing three adult spiny mice (acomys cahirinus) revealed that instances of chasing and physical displacement were quite common, while fighting and biting were rarely observed. the relationships between the most frequent behavioral categories were presented in a correlation matrix. in a second study, females tested in their home cages were dominant over males. in the males' home cages, however, no differences in the frequency of female vs. male aggression were o ...	1976	944978
a sensitive period for the development of olfactory preference in acomys cahirinus.		1976	996137
an apparent abnormaltiy of the b-cell microtubular system in spiny mice (acomys cahirinus).	the pancreatic b-cell contains microtubules, which are thought to participate in the process of insulin release. in order to disclose a possible abnormaltiy of this b-cell microtubular system in animals with islet dysfunction, isolated islets from normal rats and mice, as well as from diabetic mutant mice (dbm mice) and from spiny mice (acomys cahirinus) were incubated in the presence of vincristine, which causes the precipitation of the microtubular protein into paracrystalline deposits. ultras ...	1975	1095441
insulin secretion in the spiny mouse (acomys cahirinus). dose and time kinetic studies with glucose in vivo and in vitro.	plasma insulin responses to the intravenous injection of glucose in the doses of 0.5, 1.5, and 3.0 gm./kg. were compared in spiny mice (acomys cahirinus) and weight-matched swiss albino mice. the mean early (two-minute) plasma insulin response was significantly lower in acomys at all doses of glucose injected; whereas, at later times (5, 15, and 30 minutes), differences in plasma insulin concentrations in the two species of mice were smaller or nonexistent. plasma glucose clearance was significa ...	1975	1104397
hyperlipidemia and hepatic hyperlipogenesis in spiny mice (acomys cahirinus) on carbohydrate diets: relationship to peripheral underresponsiveness and low insulin release.		1975	1167180
ultrastructure of the oocytes of the egyptian sping mouse (acomys cahirinus).	the oocytes of types 2, 3, 4 and 5 follicles from the normal spiny mouse were examined withe the electron microsome. multiple juxtanuclear golgi bodies, mitochondria associated with flattened granular endoplasmic reticulum, and large nucleus are the main features of the type 2 follicle oocyte. the numbers of mitochondria and golgi apparati increase significantly at later stages. small mitochondrial aggregates lacking "intermitochondrial cement" are seen in the ooplasm of types 3, 4 and 5 follicl ...	1975	1171638
a primacy effect for olfactory imprinting in spiny mice (acomys cahirinus.		1975	1212161
[preliminary study of the karyotype of acomys airensis (rodentia, muridae)].		1975	1225681
breeding and fertility of the egyptian spiny mouse, acomys cahirinus: effect of different environments.	2 years experience with acomys in one laboratory confirmed the slow breeding rate found by other workers. on moving the animals to another laboratory there was a 2-5 fold increase in breeding rate. the most likely explanation of this change was the presence of copper in the drinking water at the 1st laboratory, due to the use of copper water pipes. the data relating to maintenance and breeding of acomys for 2 years at the 2nd laboratory were analyzed to provide a more representative picture of t ...	1976	1256010
naturally occurring degrading events in axon terminals of the dentate gyrus and stratum lucidum in the spiny mouse (acomys cahirinus) during maturation, adulthood and aging.	the naturally occurring dynamics of presynaptic axon terminals were investigated in the dentate gyrus and stratum lucidum of the spiny mouse (acomys cahirinus) during maturation, adulthood and aging. a sensitive and selective silver-staining technique was applied to analyze neuronal lysosome accumulation (la), indicating synaptic degradation during development. la was quantified by counting silver grains in the inner third and outer two thirds of the molecular layer, granular layer, and the infr ...	1992	1286623
[the effect of early partial postnatal deafferentation of the visual cortex on synapse formation].	a quantitative analysis of the synaptic population of the upper layers of the visual cortex of mice acomys cahirinus has shown that the process of postnatal synaptogenesis proceeds during all the period of observations (1-13 days), the intensity of morphological differentiation of various types of synapses being higher during the first 5 days of life. partial deafferentation of the visual cortex (dissection of the corpus callosum) in 3-, 5- and 13-day-old acomyses results in changes of synapses ...	1992	1343253
a relationship between circulating natural glucocorticoids and the mechanical responses of the heart in atricial and precocial rodents.	1. a comparison was made of the mechanical performance of heart muscle from mouse, an atricial mammal, with corticosterone as glucocorticoid and spiny mouse (acomys cahirinus), a precocial mammal, with cortisol as glucocorticoid. 2. force-frequency responses were negative in mouse and positive in spiny mouse. 3. during recovery, there was a gradual increase and an overshoot in the mouse, while in the spiny mouse there was an initial enhanced response, diminishing gradually with time. 4. high cal ...	1992	1361898
distance perception in the spiny mouse acomys cahirinus: vertical jumping.	acomys cahirinus, a precocial muroid, that has shown precise jumping in the natural habitat, did not jump from 25 cm in a laboratory situation. to investigate this further, a. cahirinus were observed jumping from platforms at two different heights, onto different sized checkered substrates and from a visual cliff. adult animals discriminated between platforms that were 6.4 cm and 25.4 cm above the substrate and between small and large checkered patterns on the floor. most adult animals and neona ...	1992	1454491
[a morphometric study of postnatal synaptogenesis in the neocortex of precocial and altricial rodents].	quantitative electronmicroscopic studies have been made on the development of synapses in two modally different areas of the brain (v-vi layers of the visual and auditory cortex) in the rat and mouse acomys cahirinus within first two weeks of their postnatal life. the density of synapses as well the relative amount of different types of synapses (symmetrical, asymmetrical, axo-spinal and synapses with large amounts of synaptic vesicles) were measured. it was shown that only in rats the developme ...	1992	1523896
behavioral response of altricial and precocial rodent fetuses to acute umbilical cord compression.	norway rat fetuses (rattus norvegicus) exhibit a stereotypic behavioral response when the umbilical cord is experimentally compressed with a vascular clamp. in this study, the development of the fetal behavioral response to cord compression was compared in altricial and precocial rodents, which differ markedly in neural and motor maturity at the time of birth. both altricial and precocial species showed some form of behavioral response to umbilical cord compression. fetuses of two altricial spec ...	1992	1586357
maternal discrimination and the development of sex differences in exploratory behaviour in infant spiny mice (acomys cahirinus).	the present paper reports sex differences in exploratory behaviour by infant spiny mice, acomys cahirinus, that may, in part, be related to differences in maternal behaviour towards pups; like some other rodents, mother acomys differentiate behaviourally between male and female pups. in experiment 1 infant acomys were allowed to explore a novel arena. this experiment showed that even by day 3 (the day of birth = day 1) female acomys explored a novel environment more than males; they entered the ...	1991	1771244
drinking behavior in the spiny mouse (acomys cahirinus) following putative dipsogenic challenges.	male spiny mice (acomys cahirinus) were challenged with several putative dipsogenic stimulus conditions: hypertonic sodium chloride (nacl), 24-h water deprivation, d,l-isoproterenol hcl, angiotensin ii (aii) and polyethylene glycol (peg), or control conditions, in within-subjects designs. water intake and drinking pattern were monitored electronically in the home cage over a 2--6-h test period without food present, during the light portion of the l/d cycle. in addition, hematocrits were measured ...	1991	1871204
differences in beta-adrenergic regulation of cyclic amp formation in cerebral cortical slices of the rat and spiny mouse--acomys cahirinus.	in both the rat and acomys cahirinus the adrenergic cyclic amp generating system in the brain is dependent not only on beta-, but also on alpha-adrenoceptors. the relative role of alpha-adrenoceptors is much greater in the acomys cahirinus. this feature makes the acomys an interesting animal model for investigating the role of alpha-beta-adrenoceptor coupling in generation of cyclic amp and the mechanism of action of antidepressant treatment.	1990	1980732
effect of exogenous insulin on meal patterns and stomach emptying in the spiny mouse.	male adult spiny mice (acomys cahirinus) were acutely challenged with a single dose of regular insulin or saline vehicle sc; either food intake, meal frequency and meal duration, or stomach emptying were then measured. meal frequency, as well as amount eaten, was significantly higher over a 6-hr period following both 10 and 30 u/kg of insulin than following vehicle injection. meal duration remained essentially the same across all conditions. when 30 u/kg of insulin was administered either 15 min ...	1990	2201984
an unusual pattern of copulatory behavior in a south american cricetid rodent: akodon molinae.	we describe the copulatory behavior and the morphology of the male genital tract of a member of a tribe (akodontini) for which no information on copulatory behavior has been available. copulation in akodon molinae is characterized by multiple intromissions with no intravaginal thrusting, a single ejaculation, and a brief lock with the deposit of a plug. this pattern is unusual because of the combination of locking with both multiple intromissions and plugs. the latter combination, and similar st ...	1990	2225764
animals as reservoir hosts for leishmania in qualyobia governorate, egypt.	a total of 239 rodents were collected from el-khanka, shebin el-kanater, el-kanater, shoubra el khima, qualiob, tokh, benha and kafr-shokr and identified as mus musculus (30), rattus rattus (78), rattus norvegicus (35), arvicanthus niloticus (62) and acomys cahirinus (34). examination of these rodents showed the presence of cutaneous lesions in two r. rattus, three r. norvegicus and one a. cahirinus which showed no leishmania parasites neither by smear nor by culture. on examination of the liver ...	1990	2230335
the influence of maternal labels on dietary preferences of spiny mouse weanlings.	to assess the influence of conspecific chemical cues on the development of dietary preferences, spiny mouse (acomys cahirinus) weanling were tested for their responses to food items that were partially eaten (thus, presumably labeled) by various categories of conspecifics. consumption of a highly preferred novel food (fresh carrot) labeled by the pups' parents, or mother alone, was greater than that of a clean sample of the same food. the presence of labels emanating from the father or an alien ...	1990	2236255
a comparative study of mossy fiber distribution in the brain of the precocial acomys cahirinus and of the altricial rattus norvegicus: neuroanatomical bases and behavioral correlates.	acomys cahirinus, the spiny mouse, is the only precocial murid. given the relatively advanced state of neural maturation at birth, this species is therefore of interest for comparative studies of brain and behavioural development. previous work on this species has indicated that (i) hippocampal thickness (relative to body weight) is greater in adult acomys than in rats and mice; (ii) the hippocampus appears laminated at birth, unlike that of related altricial species; (iii) the degree of olfacto ...	1985	2419270
reduced early and late phase insulin response to glucose in isolated spiny mouse (acomys cahirinus) islets: a defective link between glycolysis and adenylate cyclase.	the spiny mouse (acomys cahirinus) exhibits low insulin responsiveness to glucose with a nearly absent early phase release. the alternative fuel-secretagogue glyceraldehyde (10 mmol/l) produced a maximal early insulin response in rat islets but failed to affect early response in acomys; however, it potentiated the late insulin response in both species alike. glucagon (1.5 mumol/l) potentiated the early insulin response to intermediate (8.3 mmol/l) glucose in rat and acomys islets by two- and fou ...	1989	2477292
the development of olfactory preferences for artificial odors briefly experienced by the precocial spiny mouse young.	groups of pups, aged 2, 4, 6, 12, 16, and 18 days of the precocial murid rodent spiny mouse (acomys cahirinus), were each exposed for 1.5 h to one of the experimental odors, cinnamon or cumin, present in the surrounding environment. the odors were not contingent upon home-cage odors or any other reinforcers. this simple exposure produced a strong preference for the exposed odor in multichoice preference tests carried out 48 h after the exposure in pups from groups aged 2 through 16 days. older p ...	1989	2590153
husbandry and hematology of captive spiny mice (acomys cahirinus).		1989	2593647
prenatal neurogenesis in the telencephalon of the precocial mouse acomys cahirinus.	[3h]thymidine autoradiography was employed to examine the times of formation of the major neuronal classes in the forebrain of the precocial mouse acomys cahirinus. dams received 3 thymidine injections over a 24 h period on either embryonic day 14, 18, 20, 22, 29 or 36. age-related changes in the distribution and number of heavily labeled cells were noted. acomys exhibited later onset and more protracted periods of cell generation than the phylogenetically related, altricial laboratory rat or mo ...	1989	2616023
development of sex differences in the response of spiny mouse pups to adult male odors.	using a three-choice preference test, olfactory-mediated investigatory activity in response to adult male urine odor was examined in a precocially active rodent, the spiny mouse (acomys cahirinus) aged between 3-26 days. temporally related sex differences were seen in the time spent in the presence of the odors of father's or unfamiliar adult male's urine, or distilled (control) water. neither male nor female pups discriminated between odors from the father and strange adult males. after the fir ...	1989	2629001
trypanosoma acomys (wenyon, 1909): reproductive forms and course of parasitemia in the natural host acomys cahirinus (desmarest, 1819).	trypanosoma acomys (stercoraria, trypanosomatidae) was studied in the laboratory-bred spiny mouse acomys cahirinus. only trypomastigotes were found in peripheral blood, whereas the thymus of experimentally infected a. cahirinus showed amastigote syncytial reproductive forms whose nuclei of nuclei ranged from 2 to 128. these reproductive forms were detected 9-10 days after the i.p. injection of spiny mice with trypanosomes obtained from primary lung cultures. transitional trypomastigote-like form ...	1989	2755930
a comparative study of prenatal development in the olfactory bulb, neocortex and hippocampal region of the precocial mouse acomys cahirinus and rat.	unlike the remainder of the rodent subfamily muridae, acomys cahirinus (the 'spiny' mouse) is born in a precocial state after a long (39 day) gestation. in this paper, the development of the olfactory bulb, neocortex and hippocampal formation of acomys from prenatal days 14-34 was examined and the rate of maturation compared with that of its cousin, the laboratory rat (rattus norvegicus). at the earliest stages examined, acomys was approximately 2 days less mature than the same post-conception a ...	1989	2791267
is the high concentration of ascorbic acid in the eye an adaptation to intense solar irradiation?	ascorbic acid is known to exist in high concentration in the aqueous humor of the eye in many species. it has been observed that diurnal mammals have a very high concentration in aqueous humor whereas nocturnal mammals do not. it has been hypothesized that ascorbic acid protects the eye from the harmful effects of sunlight. we have discovered that of two closely related species of spiny mice, the diurnal species (acomys russatus) has a concentration in aqueous humor that is 35 times higher than ...	2009	2793364
a comparison of locomotor responses to some psychotropic drugs and cerebral receptors in the acomys cahirinus and the laboratory mouse.	comparative studies of the laboratory mouse and acomys cahirinus have shown differences in their motor activity patterns and motor responses to morphine, apomorphine and clonidine. the two species also differed in respect of the density of cerebral alpha 2-adrenergic receptors, but no significant differences between other types of receptors (alpha 1-adrenergic, beta-adrenergic, opiate mu and delta, and spiroperidol binding sites) were found. it is suggested that the high excitability of the acom ...	1987	2830608
a comparison of postnatal thermal physiology and energetics in an altricial (gerbillus perpallidus) and a precocial (acomys cahirinus) rodent species.	1. daily weight increase is polyphasic in gerbillus perpallidus whereas it follows a linear pattern in acomys cahirinus. 2. young a. cahirinus achieve full homeothermic capacities much earlier (less than or equal to 12 days old) than g. perpallidus (19-21 days old). 3. the differences in the development of the two species are reflected in the alterations of their metabolic rates. 4. in both species, age-dependent phases of development are obvious, beginning, however, much later in g. perpallidus ...	1988	2900101
electrophysiological effects of dopamine receptor stimulation in the hippocampus of acomys cahirinus.	the effect of dopamine receptor agonists on the spontaneous bioelectrical activity of ca1 layer neurons in the hippocampal slice preparation from the acomys and rat has been studied. the selective d1 receptor agonist skf 38393 diminished the neuronal firing rate while the selective d2 receptor agonist ly 171555 (quinpirole) evoked an excitatory reaction, however, a great proportion of hippocampal neurons remained unresponsive to skf 38393 and ly 171555. both dopamine and apomorphine elicited mai ...	1988	2908137
effect of insulin and 2-deoxy-d-glucose on feeding and plasma glucose levels in the spiny mouse.	adult male spiny mice (acomys cahirinus) were challenged with 2-deoxy-d-glucose (2-dg) or regular insulin, and food intake or plasma glucose concentration was measured. mice did not increase their food intake over baseline levels following treatment with 2-dg (62.5-1000 mg/kg). in contrast, regular insulin injections (1-50 u/kg) stimulated a modest, but significant increase in feeding, which was apparent within 2 hr at a low dose of 1 u/kg. however, a marked hyper- and hypoglycemia (compared to ...	1988	3070582
the acomys cahirinus (spiny mouse) as a new model for biological and neurobehavioural studies.	acomys cahirinus is a precocial murid and a comparison of its development with altricial species of the same family, such as the rat and mouse, may shed some light on the relationship between genetic and environmental factors in the development. the use of acomys in neurobehavioural studies and its comparison with mouse and rat may be particularly profitable. behavioural, differences particularly in the exploratory behaviour, are paralleled by differences in the brain anatomy. therefore acomys s ...	1988	3075753
a comparative study of myelination in precocial and altricial murid rodents.	the development of myelin staining was compared in two closely related rodent species, the precocial acomys cahirinus and altricial rattus norvegicus. while the progression of myelin staining was similar in both species (motor tracts myelinated before sensory systems, which were followed by forebrain fiber systems), the timing of maturation differed considerably: (1) at the same postconception age (pc38) rattus was substantially more mature than acomys, suggesting a relatively earlier onset of m ...	1988	3219591
species differences in hepatic microsomal drug-metabolizing enzymes.	the activity of some metabolizing enzymes was assessed in the liver microsomes of acomys cahirinus, mice and rats. the enzymatic studies were followed by the determination of cerebral level of apomorphine (apo), imipramine (imi) and its metabolite desipramine (dmi) of animals treated with a single dose of apo or imi. it was found that the level of cytochrome p-450 and the activity of imi demethylase and glucuronyltransferase in the liver microsomes of rats was significantly higher than those in ...	1988	3222176
a comparison of norepinephrine stimulated inositol phosphate accumulation in cerebral cortex of the acomys cahirinus, the laboratory mice and the rat.		1988	3222183
brain choline acetyltransferase and muscarinic receptor sites, brain and liver cholinesterases in precocial acomys cahirinus and altricial rat during post-natal development.	brain choline acetyltransferase, acetylcholinesterase with its molecular forms, and muscarinic receptor sites, as well as liver total cholinesterases were evaluated during the first postnatal month in pups of a precocial (acomys cahirinus) and altricial (rat) murid species. at birth the levels of brain cholinergic markers were higher in the acomys than in the rat, but in adulthood the differences were smaller or even reversed. the postnatal increase up in the markers to weaning was considerably ...	1988	3253718
effect of electrical stimulation of the vagus nerve on insulinemia and glycemia in acomys cahirinus mice.	to investigate the parasympathetic regulation of the endocrine pancreas in spiny mice (acomys cahirinus), unilateral electrical stimulations of the left cervical vagus nerve were performed in these animals and their controls, the albino mice. plasma insulin and glucose levels were measured before and after the stimulation. the stimulation parameters were: 2-2.5 v, 14 hz, 1 msec for the albino mice and 3 v, 14 hz, 1 msec or 15-20 v, 20 hz, 1 msec for the spiny mice. already 2 min after the start ...	1988	3293988
precocity and plasticity: odor deprivation and brain development in the precocial mouse acomys cahirinus.	altering the early olfactory environment of animals can have dramatic consequences on the development of brain regions which subserve olfaction. the present study indicates that early odor deprivation has a more severe effect on a species which is born relatively mature than it does on related species which are not. the results call into question prevailing notions about the developmental continuity between animals born in divergent ontogenetic states.	1988	3362353
[the features of the hippocampal structure as a neuroanatomical basis for differences in behavior].	neuromorphological and behavioural studies have been made on several strains of mice (c57b1, dba/2, sec) and on the spiny mouse acomys cahirinus. it was shown that animals with different genotypes differ by the size of fascia dentata and by the extension of the pyramidal layer in ca3 field of the hippocamp. animals with a higher learning capacity exhibited smaller layer of granular cells in the fascia dentata, which may be due to a lower density of neurones in this region. terminals of the mossy ...	1987	3434039
postnatal maturation of brain cholinergic systems in the precocial murid acomys cahirinus: comparison with the altricial rat.	the spiny mouse (acomys cahirinus) is the only precocial murid species. it has some neuroanatomical peculiarities such as a relatively thin cerebral cortex and a large hippocampus. the levels of choline acetyltransferase, membrane-bound acetylcholinesterase and muscarinic receptor sites (measured as [3h]quinuclidynil benzilate binding) were assessed in the whole brain on days 1, 7, 14, 21, 28 and 80 (adult), and compared with those of wistar rats of the corresponding ages. at birth choline acety ...	1986	3455597
hormones in perinatal rat and spiny mouse: relation to altricial and precocial timing of birth.	rat (rattus norvegicus) and spiny mouse (acomys cahirinus) are closely related murine species that, due to their altricial (rat) and precocial (spiny mouse) modes of development, differ in the developmental timing of birth. a comparison between the developmental profiles of plasma glucagon, insulin, thyroxine, triiodothyronine, and glucocorticosteroid hormone was carried out to elucidate the question to what extent these hormonal profiles were related to the timing of birth. although corticoster ...	1986	3524260
[comparative study of the brain of developed and underdeveloped neonatal rodents of the muridae family].	morphological studies have been made of the neocortical and archicortical structures in the spiny mouse acomys cahirinus, the only maturely born species from the family muridae. the data obtained reveal highly developed hippocampus as compared to the neocortex in this mouse, in contrast to relationships found in other mice and rats.	1987	3564772
opioid modulation of ingestive behaviors in the spiny mouse (acomys cahirinus).	feeding and drinking behavior were studied in deprived or sated spiny mice (acomys cahirinus) at various time intervals following peripheral administration of naloxone hydrochloride and butorphanol tartrate. naloxone attenuated both food and water intake, but not latency to respond, indicating existence of functional opioid-sensitive feeding and drinking systems in this species. butorphanol tartrate, a mixed opioid agonist/antagonist produced a dose-related enhancement or suppression of feeding, ...	1987	3613855
species differences in polysaccharide and sugar taste preferences.	this study compared the polysaccharide and sugar taste preferences of humans and four rodent species (laboratory rats, rattus norvegicus; golden syrian hamsters, mesocricetus auratus; mongolian gerbils, meriones unguiculatus; egyptian spiny mice, acomys cahirinus). in experiment 1 human subjects rated the pleasantness, sweetness, and flavor intensity of polysaccharide (polycose), sucrose, and maltose solutions at concentrations of 0.0125 m to 0.4 m, and 1% to 32% concentrations. at the higher mo ...	1987	3614791
effects of odor familiarity on the development of systematic exploration in the spiny mouse, acomys cahirinus.	developmental changes in patterns of exploration by infant spiny mice, acomys cahirinus are described. these were investigated using an unbaited radial maze and under three odor conditions; that is, animals were tested in the presence of either familiar (own) odors, unfamiliar conspecific odors, or no odors (washed floor). two hypotheses were tested. the first was based on the results of a pilot study, and was that adult animals would explore the radial maze in a systematic and predictable fashi ...	1987	3691969
physical and behavioral sequelae of low birthweight in spiny mice (acomys cahirinus).	physical and behavioral sequelae of low birthweight (lbw) were investigated in spiny mice (acomys cahirinus). when raised by their biological mother, pups whose day-2 weights were 1 sd or more below the population mean remained smaller through the first 30 days postpartum than pups born within normal (n) weight ranges. lbw pups fostered onto mothers who gave birth to n pups gained weight more rapidly than lbw pups remaining with their own mother. similarly, n pups fostered onto mothers of lbw pu ...	1986	3758489
correction of diabetic pattern of insulin release from islets of the spiny mouse (acomys cahirinus) by glucose priming in vitro.	insulin release kinetics were studied in perifused islets of langerhans, isolated from mildly hyperglycaemic and from normoglycaemic spiny mice (acomys cahirinus), a rodent predisposed to develop spontaneously non-ketotic diabetes. in both groups, insulin response to glucose (16.7 mmol/l) was delayed in comparison with that of rat islets, the release kinetics being analogous to that of human type 2 (non-insulin-dependent) diabetes. thirty min priming of the isolated acomys islets with glucose (1 ...	1985	3894135
perinatal development of the small intestine and pancreas in rat and spiny mouse. its relation to altricial and precocial timing of birth.	rat (rattus norvegicus) and spiny mouse (acomys cahirinus) are closely related species that mainly differ in the developmental timing of birth. a comparison between the developmental profiles of some characteristic enzymes of the small intestine (lactase and sucrase) and of the pancreas (amylase) of both species was carried out to elucidate the question to what extent these enzymic profiles and hence the maturation of these organs was related to the process of birth. it was found that these orga ...	1985	3921064
patterns of exploratory behavior in the spiny mouse, acomys cahirinus.	the present paper reports an investigation of patterns of exploratory behavior shown by laboratory-bred spiny mice (acomys cahirinus) when given access to a large, novel arena. the aim was to test hypotheses suggested by our previous work with this species. previous experiments in which the exploratory behavior of acomys was compared with that of mus had suggested that each species had a characteristic pattern of emergence and exploration. the present experiment addressed the question of whether ...	1986	3954718
perinatal development of the liver in rat and spiny mouse. its relation to altricial and precocial timing of birth.	rat (rattus norvegicus) and spiny mouse (acomys cahirinus) are closely related murinoid species that mainly differ in the developmental timing of birth. a comparison between the developmental profiles of some characteristic enzymes of the liver of both species was carried out to elucidate the question to what extent are these enzymic profiles and hence the maturation of the liver related to the timing of birth? it was found that these organotypic enzymes first become detectable at the same devel ...	1985	3967668
a stereological study of neocortical maturation in the precocial mouse, acomys cahirinus.	the development of neocortical area 17 of acomys cahirinus was studied by quantifying changes in the numerical density of neurons and glia, and by examinations of subjects treated on the day of birth with tritiated thymidine. unlike most laboratory species, acomys is born in a relatively advanced state, with open and functional ears and eyes and coordinated locomotor abilities. rapid neocortical growth occurred during the first 60 postnatal days and was accompanied by a 65% decrease in neuronal ...	1985	3995352
exploratory behavior of two species of murid rodents, acomys cahirinus and mus musculus: a comparative study.	the exploratory behavior of two species of murid rodents, acomys cahirinus and mus musculus, was compared in four experiments: in the first, the responses of the two species to a novel arena were studied. mus was found to take longer to enter the arena, and to spend more time in the relatively familiar or safer start box, than was acomys. the results suggest that acomys may persevere longer in exploring particular areas, whereas mus appear to explore in the open arena by using frequent shifts of ...	1985	4004686
[autofluorescent granules in the ependyma of recessus inframamillaris of young prickle mice (acomys cahirinus dimidiatus)].		2014	4208001
a breeding program for spontaneously diabetic experimental animals: psammomys obesus (sand rat) and acomys cahirinus (spiny mouse).		1968	4233365
[autofluorescent granules in the ependyma of the recessus inframamillaris of the yellow spiny mouse (acomys cahirinus dimidiatus)].		1972	4339918
defective immunoreative insulin secretion in the acomys cahirinus.		1972	4343799
metabolic adaptation of spiny mice (acomys cahirinus) transferred from the desert to laboratory diets.		1974	4370735
evidence for decreased sensitivity to glucose of isolated islets from spiny mice. (acomys cahirinus).		1974	4375063
[electron microscope detection of biogenic amines in the medulla of the adrenal gland of the normoglycemic spiny mouse (acomys cahirinus)].	by means of a modification of the reinecke salt method already described, characteristical amine containing granules have been demonstrated in the parenchymal cells of the adrenal medulla in normoglycemic spiny mice. by this method two types of granules have been discerned according to their different contrasts. the advantages of the modification method are discussed.	1974	4377491
testosterone biosynthesis in the desert mouse, acomys cahirinus.		1971	4399441
olfactory imprinting resulting from brief exposure in acomys cahirinus.		1974	4414896
the effect of dietary sucrose on plasma lipids and on the liver of the spiny mouse (acomys cahirinus).		1974	4419533
decreased intravenous glucose tolerance and low plasma insulin response in spiny mice. (acomys cahirinus).		2015	4448329
haemoglobin of the spiny mouse (acomys cahirinus) (starch gel electrophoresis, chromatographic fractionation).		1972	4636757
androgen biosynthesis by testicular tissue of the desert rodents, acomys cahirinus and gerbillus dasyurus.		1973	4737075
seasonal observations on the cairo spiny mouse, acomys cahirinus (e. geoffroy, st. hilaire, 1803) and its fleas in egypt.		1973	4804345
effects of previous exposure on olfactory discrimination in acomys cahirinus.		1974	4833517
recent advances in mechanism of causation of diabetes mellitus in man and acomys cahirinus.		1974	4858609
ultrastructural studies of the hyperplastic islets of langerhans of spiny mice (acomys cahirinus) before and during the development of hyperglycemia.		1967	4907140
metabolic state, pancreatic insulin content and b-cell morphology of normoglycemie spiny mice (acomys cahirinus): indications for an impairment of insulin secretion.		1970	4914669
[morphological and physiological lesions in the complex syndrome of spiny mice (acomys cahirinus)].		1968	4917933
[the autonomous nervous system and the b-cell: metabolic and morphological observations made in spiny mice (acomys cahirinus) and in cultured fetal rat pancreas].		1970	4919942
[effect of age on the avoidance conditioning of acomys cahirinus (desmarest) (rodents, muridae)].		1971	5001914
interstitial nephritis in the spiny mouse (acomys cahirinus) associated with klossiella sp. infection.		1970	5005922
isolation and partial structural analysis of insulin from mouse (mus musculus) and spiny mouse (acomys cahirinus).		1972	5028210
adaptive responses in enzyme activities of israeli spiny mice (acomys cahirinus).		1972	5041252
hyperlipidemia and impaired glucose tolerance in acomys cahirinus maintained on synthetic carbohydrate diets.		1972	5055380
[spontaneous diabetes in a new spiny mice strain, acomys cahirinus cahirinus(desmarest 1819)].		1971	5114353
[obesity and diabetes mellitus in acomys cahirinus].		1971	5145545