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[differential staining of hamadryas baboon chromosomes with romanovsky-giemsa dye (g-discs)].the pattern of g-discs in the chromosomes of baboon (papio hamadryas) was studied after staining by means of asg method. on the basis of these data all the 20 pairs of autosomes and sex chromosomes were identified. according to the distinctness of the discs all the chromosomes were classified into 3 groups: well differentiated, faintly differentiated and moderately differentiated. the most distinct pattern of discs was obtained in slightly spiralized chromosomes. dimorphism of the disc pattern i ...197556287
[chromosome identification in macaca arctoides based on study of the differential staining pattern (g-discs). comparison with papio hamadryas g-discs].linear chromosome differentiation pattern of macaca arctoides was studied using the romanovsky-gimsa stain (g-banding). the possibility of the identification of all chromosome pairs according to these data is demonstrated. the phenomenon of the irregular intercellular and chromosome differentiation is found out and a suggestion is made about its relation to a real mosaic functional activity of cell genomes. a great similarity in linear chromosome differentiation for 2 from 42 studied chromosome ...197556288
[identification of simian chromosomes by a method of differential staining with romanovskii--giemsa solution. ii. papio hamadryas].by means of differential staining wiyh the romanovsky-- gimsa dye the distribution of g-bands was studied in chromosomes of bone marrow cells and of cultured peripheral blood lymphocytes in papio hamadryas. all the homologous chromosome pairs were identified. it was shown, as compared papio hamadryas karyotoypes with that of macaca mulatta, that patterns of most chromosomes differentiation were similar. certain differences between these species were observed in the character of differentiation o ...197557902
virological studies of baboon (papio hamadryas) lymphoma: isolation and characterization of foamyviruses.in accordance with a memorandum of understanding in cancer research between scientists in the ussr and the usa, virological studies were performed on two baboons from the russian colony at the institute of experimental pathology and therapy at sukhumi where several cases of leukemia have been observed over the past few years. foamyvirus isolations were made from lymphoid cells of both of these monkeys, one of which had a confirmed case of lymphoma. the isolates were similar to each other serolog ...197658063
[identification of simian chromosomes by the differential staining method with romanovskii-giemza stain. ii. papio hamadryas].by means of differential staining with the romanovsky - gimsa dye the distribution of g-bands was studied in chromosomes of bone marrow cells and of cultured peripheral blood lymphocytes in papio hamadryas. all the homologous chromosome pairs were identified. it was shown, as compared papio hamadryas karyotypes with that of macaca mulatta, that patterns of most chromosomes differentiation were similar. certain differences between these species were observed in the character of differentiation of ...197560271
antigenic characterization of c-type oncornavirus isolated from lymphomatous baboon (papio hamadryas).antigens of biln c-type oncornavirus isolated from lymphomatous baboon were studied in the double immunodiffusion. the major viral protein (p-30) of this virus possesses interspecies antigenic determinants (gs-3). this protein also revealed close antigenic relation to the p-30 of rd-114 and m-7 c-type oncornaviruses. specific serum against biln p-30 has been produced. the comparison of the three test-system (p-30s of m-7, rd-114, and biln, and specific sera against them) did not allow to disting ...197660981
[nature of changes in the level of steroid hormones and their precursors in peripheral blood of papio monkeys under stress].the radioimmunological method was applied to determination of changes in the peripheral blood plasma level of 12 steroids in male papio hamadryas under immobilization and surgical stress. androgen content decreased, and the concentration of steroid hormone precursors and hydrocortisone blood plasma content rose in response to stress. these changes were in contraphase with the circadian steroid rhythms. the most objective and sensitive criteria of the stress situation evaluation were decrease of ...197896885
[cytoarchitectonics of ileocecal lymph nodes in newborn and sexually mature simians (pavian hamadrils)].cell composition of various components (cortical plateau, folliculi and cords) of ileocecal lymph nodes was studied in newborn, 1.5 and 2.5 months of age (2 animals) and in mature (3 animals) monkeys, papio hamadryas. in histological sections obtained at the level of hilus of the lymph node cellular elements were counted by means of morphometric grid of glagolev modifoed by s. b. stefanov. the data obtained were statistically treated. newborn and mature monkeys have their peculiar cytological pr ...197898135
[steroid metabolism in primates. xx. excretion of c21-steroids in urine of women and baboons (papio hamadryas) during pregnancy].urinary excretion of 10 c21 steroids was investigated in women and baboons (papio hamadryas) in various stages of pregnancy, in comparison to controls. in pregnant women, excretion of total c21 steroids is slightly increased, whereas in pregnant baboons it is slightly decreased. in women, excretion of tetrahydrocortisol and tetrahydrocortisone is diminished, that of 20 beta-oh-f (11-beta,17alpha,20beta,21-tetrahydroxy-4-pregnen-3,20-dione) and of 11-deoxycortisol is increased. in pregnant baboon ...1998104866
effect of stress on the profile of plasma steroids in baboons (papio hamadryas).adult baboons (5 males and 5 females) were exposed to immobilization stress by being strapped to a table in a horizontal position for 2 h. in females the experiment was performed during both the follicular and luteal phase. peripheral blood was withdrawn at frequent intervals, the first sample just before immobilization, and the last one 3 days later. a number of steroids were measured in blood plasma samples by radioimmunoassay (17-hydroxypregnenolone, 17-hydroxyprogesterone, pregnenolone, test ...1979105533
[radioimmunologic method of determining 11 steroids in small samples of monkey blood plasma].a radioimmunological method is described for simultaneous estimation of hestagenes, estrogenes, androgenes and their precursors in small samples of blood plasma obtained from peripheric blood of hamadryads (papio hamadryas) and macaques (macaca rhesus). use of highly specific antisera and of chromatographic isolation of each steroid on columns with celite enabled to estimate the concentration of 11 steroids in 1.1 ml of blood plasma with high accuracy. standard curve and analysis of its linearit ...1979106544
[postcoital contraception in primates. ii. examination of sts 153 and sts 287 as interceptives in the baboon (papio hamadryas)].the interceptive activity of 2 new synthesized steroid compounds: sts 153 (17 beta-phenylaminocarbonyloxy-estra-1,3,5(10)-triene-3-methyl ether and sts 287 (16 alpha-bromo-17 beta-[n',n'-dimethylhydrazino]-carbonyloxy-estra-1,3,5(10)-triene-3-methyl ether) and of 17 alpha-ethynylestradiol was investigated in baboons.--postcoital oral administration of 1--3 mg/kg b. w. sts 153 for 5--7 days and of 1 mg/kg b. w. sts 287 for 5 days resulted in a fertility inhibition of about 90% and 95% respectivel ...1998106578
luteinizing hormone levels during the menstrual cycle of the baboon (papio hamadryas). 1998110021
[age and thymus morphology of pavian hamadrils].by different histological methods, 23 thymi have been studied in papio hamadryas of 5 age groups: fetuses, newborn, one-year-old, mature and old animals. by morphometric methods percentage of quantitative relations of the cortical and medullary substances, as well as their cell composition have been estimated. a rather great similarity in morphogenesis and age histology has been noted in human and monkey thymus. the character of histochemical reactions in thymus corpusculi supports the view on p ...1979111648
[experimental protective of fraction i of the plague microbe].the immunogenic properties of the freeze-dried preparation of fraction i tisolated from the culture of avirulent pasteurella pestis strain were studied in experiments on hamadryas baboons, guinea-pigs and white mice. the preparation was found to have a pronounced protective effect in hamadryas baboons and white mice, especially when the preparation was used in mixture with incomplete freund adjuvant. in hamadryas baboons resistance to infection was shown to correlate with hemagglutionation antib ...1979116458
[ileo-colonic lymph nodes in macaques and pavians of different ages].quantitative and qualitative alterations occurring in various structural components of the ileocolonic lymph nodes of papio hamadryas at the age of 3.5 months and 5 years and macaca rhesus at the age of 5 years were studied by means of mathematical methods. cellular composition was counted in every histological preparation per 1,000 cells in cortical plateau, in myelin cords, in follicles with light centers and in follicles without light centers. part (in %) of every cell variety was determined, ...1979116628
immunofluorescent and immunoelectron microscopic demonstration of primate heart muscle antigens cross-reactive with streptococcus pyogenes.the presence of antigens in heart muscles cross-reactive with antibodies against streptococcus pyogenes were examined in heart samples of seven primate species (chimpanzee, rhesus macaque, stump-tailed macaque, hamadryas baboon, capuchin monkey, green monkey and patas monkey). cross-reactive antigens were localized by means of the indirect immunofluorescent technique in nearly all samples tested. the fluorescence pattern was the same as found in the heart muscle of other mammals. using the indir ...1979116866
surface adhesive properties of baboon lymphocyte and derived lymphoblastoid cell lines.cell surface adhesiveness of lymphocytes isolated from the peripheral blood of papio hamadryas monkeys was compared to the adhesiveness of lymphoblastoid cell lines derived by transformation of these lymphocytes with herpesvirus papio. for the quantitative comparison of the cell surface adhesive properties, a recently developed latex particle adherence assay was utilized. it was found that cell surface adhesiveness of the suspension lines was substantially lower than that of their precursor lymp ...1979119650
[steroid metabolism in primates. xvi. secretion of corticosteroids in the baboon papio hamadryas during chronic administration of sodium chloride].the adrenal steroid secretion was investigated in male baboons (papio hamadryas) treated for a long time with sodium chloride, in comparison to an untreated control group. in animals treated with nacl, the secretion of progesterone, 17alpha-hydroxyprogesterone, 11-deoxycortisol, aldosterone and corticosterone was decreased, while cortisone, pregnenolone, 7-keto-cholesterol, 7-keto-dhea, dhea and adrenosterone were increased.1975125195
hormonal changes during the menstrual cycle of the baboon (papio hamadryas).eleven unconjugated steroids were measured daily during a complete cycle in the peripheral plasma of 6 normally menstruating baboons (papio hamadryas) by means of a radioimmunoassay procedure and the levels were compared with those found previously in 17 normally menstruating women. the patterns of progesterone and 20alpha-dihydroprogesterone were very similar to those found in women throughout the entire menstrual cycle. however, the ratio of these steroids differed markedly from that found in ...1976132074
plasma levels of unconjugated steroids in male baboons (papio hamadryas) and rhesus monkeys (macaca mulatta).in an attempt to find suitable animal models to aid in the study of the reproductive processes of the human male, plasma levels of unconjugated pregnenolone, 17-hydroxypregnenolone, dehydroepiandrosterone, 20alpha-dihydroprogesterone, 17-hydroxyprogesterone, androstenedione, testosterone, dihydrotestosterone, oestrone and oestradiol were measured in 18 male baboons and 10 male rhesus monkeys and the steroid levels were compared with those previously established in normospermic, middle-aged men. ...1976132836
anatomically orthogonal qrs electrocardiogram of the baboon (papio hamadryas) and the macaque (macaca mulatta). sex and species differences.peak amplitudes of the qrs complex were evaluated in 28 adult macaques (macaca mulatta) and 28 adult baboons (papio hamadryas), using two anatomically orthogonal lead systems. the anteroposterior (z) and the transversal (x) component of the cardiac electric field was smaller in females than in males. comparison of qrs amplitudes in baboons and macaques indicates that the loop of the spatial vectorcardiogram is situated further ventrally and to the right in the former. the relationship between ve ...1977140402
[demonstration by immunofluorescence of somatotropic cells and prolactin cells in the monkeys erythrocebus patas, cercopithecus aethiops and papio hamadryas].using antibodies against human sth and ovine prolactine, it is possible to identify somatotropic and prolactin cells in the pituitary anterior lobe of three species of monkeys: erythrocebus patas, cercopithecus aethiops and papio hamadryas. the somatotropic cells are numerous in both adult and infant male or female monkeys, especially in the lateral lobes of the pituitary gland. the prolactin cells can be distinguished in all pituitaries studied, regardless age or sex; indeed there are more nume ...1976140737
inbreeding, lymphoma, genetics and morphology of the papio hamadryas colony of sukhumi. 1978156794
[plasma androgen levels in papio hamadryas pavian hamadrils at different periods of postnatal development].using radioimmunological assay, it has been demonstrated that at the age of 0.5, 1 and 2 years sexual differences are absent in the concentration of testosteron, 5 alpha-dihydrotestosteron, dehydroepiandrosteron and delta 4-androstendion in the blood plasma. the level of testosteron in sexually immature animals does not differ from that in adult females. in sexually mature baboons, testosteron content was found to be more than 20 times higher. the activity of 5 alpha-reductase, checked by the ra ...2013157660
[demonstration by immunofluorescence of somatostatin cells in the islets of langerhans in 3 species of monkeys].indirect immunofluorescence technique with anti-somatostatin serum has allowed us to detect somatostatin containing cells in the langerhans' islets of three species of monkeys (macacus irus, papio hamadryas, cercopithecus aethiops). these cells are in close relationship with another cells, but occupy a more central position in the islets. thus, the distribution of somatostatin-containing cells in the monkey's endocrine pancreas has not a similar pattern as in rodent's pancreas; they have a compa ...1979160269
[immunofluorescence demonstration of somatostatin-containing cells in the digestive tract of the monkeys irus, macaca papio hamadryas and cercopithecus aethiops].indirect immunofluorescence technique with antisomatostatin serum has allowed us to detect somatostatin containing cells in the gastro-intestinal tract of three species of monkeys : macacus irus, papio hamadryas and cercopithecus aethiops. these cells are localized only in the stomach, in the duodenum, and in the jejunum-ileum. no somatostatin cells were encountered in the esophagus and in the colon. the maximum of somatostatin positive cells is localized in the duodenum, as well in the lieberkü ...1979161187
[preparation of suspension lymphoblastoid cell cultures, containing herpes-like viruses, from hematopoietic organs of hamadryas baboons with hematosarcoma]. 1975165924
[generic characteristics and specific characteristics of the ponto-geniculo-occipital spike activity (pgo) in 2 baboons, papio hamadryas and papio papio]. 1975167907
[comparative characteristics of 2 c-type oncornaviruses isolated from hamadryas baboons with hemoblastosis]. 1975173511
cell surface antigens detected in cell lines established from lymphomatous papio hamadryas and macaca arctoides monkeys.cell surface antigens associated with bone marrow cell cultures from leukemic monkeys of species papio hamadryas and macacus arctoides were visualized by means of an indirect immunofluorescence method with sera from leukemic baboons. the same immune serum gave two types of immunofluorescence, depending on the origin of the target cells. fluorescence of the ring-reaction type was seen with papio hamadryas bone marrow cell cultures growing in suspension and containing the baboon herpesvirus, where ...1976185533
properties of a baboon lymphotropic herpesvirus related to epstein-barr virus.three lymphoblastoid cell lines were established from splenic lymphocytes of a lymphomatous baboon (papio hamadryas) by co-cultivation of the lymphocytes with x-irradiated cells of marmoset or baboon lymphoblastoid cell cultures; the baboon splenic lymphocytes failed to grow when cultured alone. a herpesvirus, associated with each cell line, was identified by immunofluorescence, molecular hybridization and electron microscopy. antigenic comparison with epstein-barr virus (ebv) showed that the ba ...1976186420
[effect of chlorimipramine on the so-called ponto-geniculo-occipitalactivity (pgo) in a primate, papio hamadryas (author's transl)].three hamadryas adult baboons (female) received 24 daily injections of chlorimipramine (1.7 mg/kg). the effects on sleep were nearly identical with the effects observed in man. pgo activity, recorded in the lateral geniculate nucleus, was much disturbed. the total number of pgo fell downward from the first recording. the number of pgo/min during paradoxial sleep was even more decreased. this fact suggests a selective influence of cl i on the mechanisms of pgo activity. is the particular effect o ...1977191866
[demonstration by immunofluorescence of adenohyphysis corticotropin and melanotropin cells in erythrocebus patas, cercopithecus aethiops and papio hamadryas].using antibodies against synthetic corticotropic hormones (1-24 acth and 17-39 acth), and melanotropic hormones (alpha-msh and beta-msh), it is possible to identify corticotropic and melanotropic cells in the adenohypophysis of three species of monkeys : erythrocebus patas, cercopithecus aethiops and papio hamadryas. the corticotropic cells are numerous in the anterior lobe in both the adult and infant male and female monkeys of these three species. the intermediate lobe reacts with antibodies a ...1977196718
nonhuman primates: laboratory animals of choice for neurophysiologic studies of sleep.a systematic study was made of several nonhuman primates to learn more about their relative usefulness for studies of sleep. species studied included the guinea baboon (papio papio), kenya or yellow baboon (p cynocephalus), olive baboon (p anubis), sacred baboon (p hamadryas), vervet monkey (cercopithecus aethiops), rhesus monkey (macaca mulatta), bonnet monkey (m radiata), crab-eating monkey (m fascicularis), patas monkey (erythrocebus patas), chimpanzee (pan troglodytes), mongoose lemur (lemur ...1977201798
further characterization of a herpesvirus-positive orang-utan cell line and comparative aspects of in vitro transformation with lymphotropic old world primate herpesviruses.an orang-utan (pongo pygmaeus) suspension line, cp81, was shown to lack myeloid markers of lysozyme activity an d phagocytosis but to be positive for lymphocytic n-alkaline phosphatase activity, and to release a b-cell-tropic herpesvirus. this herpesvirus, termed herpesvirus pongo, had 30--40% dna homology with ebv and was present at 2-3 genome copies per cp-81 cell. gibbon lymphocytes transformed by h. pongo, epstein-barr virus (ebv), and h. papio (of baboon, papio hamadryas, origin) were found ...1978208990
antibody responses to herpesvirus papio antigens in baboons with lymphoma.an epstein-barr virus-related herpesvirus, termed herpesvirus papio (hvp), was isolated from baboons (papio hamadryas) at the institute of experimental pathology and therapy, sukhumi, ussr, where there is a continuing outbreak of lymphoma. in the present study sera from diseased baboons and from age- and sex-matched control animals were examined for antibodies to hvp antigens. results showed that animals with lymphoid disease had antibodies to hvp virus capsid, early, soluble, and nuclear antige ...1979216640
intracortical horizontal connections of neurons in cat and monkey motor cortex.the present paper deals with the study of the structure of horizontal neuron chains, one of the aspects of intracortical intraneuronal relationships. the motor cortex (field 4) of cats and lower monkeys (papio hamadryas and macacus rhesus s. m. mullata) was treated by the impregnating method of golgi--kopsh. the drawings of neurons from 90-micrometer sections were made by means of a camera lucida. three possible pathways of impulse transmission along neuron chains in a horizontal direction were ...1978216813
identification of the soluble hvp-associated antigen of the lymphoblastoid cell line established from lymphomatous baboon (papio hamadryas).a new technique (indirect double immunodiffusion) for detection of ebv-associated soluble antigen and corresponding antibodies has been developed. this technique includes three steps: 1) simple double immunodiffusion with extracts of raji cells (or other ebv-genome positive cells) and human sera containing antibodies against ebv-associated soluble antigen; 2) extensive washing and treatment with anti-human globulin; 3) extensive washing and treatment with tannic acid. using this test it was show ...1978219644
prevalence of antibodies to soluble antigen of epstein-barr virus-producing cells (p3hr-1) in the sera of hamadryas baboons of the high lymphoma incidence stock.soluble antigen of p3hr-1 cells (sa-p3hr-1) was identified in indirect double immunodiffusion enhanced with tannic acid using serum of a nasopharyngeal carcinoma patient containing high-titer antibodies to epstein-barr virus (ebv) antigens. sa-p3hr-1 was nonidentical to soluble antigen of raji cells. human and baboon sera containing antibodies to all the known antigen of ebv and hvp respectively were anti-sa-3hr-1-positive. human and baboon sera containing antibodies to all the known antigens of ...1979231520
[identification of mycoplasmas isolated from monkeys].the authors identified 15 strains of mycoplasmae isolated from papio hamadryas suffering from leukemia and from healthy macacus rhesus, a green monkey and saimiri. a study was made of their biochemical properties, antigenic properties in the reaction of growth depression with immune sera to a number of standard strains, and also the protein composition by electrophoresis in polyacrylamide gel (epag). a number of mycoplasmae were identified as a. laidlawii, m. arthritidis--campo and m. cynomolgus ...1975235821
[characteristics of the ovarianc cycle in the baboon (papio hamadryas)].the dynamics of estradiol, estrone, 17 alpha-hydroxyprogesterone, progesterone and 20 alpha-dihydroprogesterone were investigated in the blood plasma of the pavian (papio, hamadryas) with regard to the menstrual cycle and in comparison with the human. furthermore results were presented about the basal temperature, the fern phenomenon and the development of the sex-skin in the pavian.1978349964
[microscopic structure of the mesenteric lymph nodes of monkeys].the structure and cytoarchitectonics of mesenterial lymph nodes were studied in thin histological sections by different methods. under study were 5 rhesus monkeys and 3 hamadryas baboons. the square surface of different structural elements of the nodes (the cortical and medullary substances, follicles, the connective tissue framework, sinuses) occupied by them in sections was calculated and the amount of cellular elements was determined (%). comparison of the data obtained in rhesus monkeys and ...1977404995
[cytological structure of the thymus gland in mature monkeys].histological sections of the thymus were studied morphometrically in 5 rhesus monkeys and 3 hamadryas baboons. the ratio of square surfaces of the cortical and cerebral substance, the percentage of hassall's corpuscles and cellular elements (lymphocytes, stromal elements, blasts etc.) were established in the organ. individual and species peculiarities of the structure of thymus elements were found. less amount of parenchyma and growth of the stroma in baboons and a greater mitotic complex in rhe ...1977405958
[chromosomes of 3 lymphoblastoid suspension cell lines obtained from baboons with malignant lymphoma].three suspension cell lines from bone marrow (bmph-1) and spleens (sph-2 and sph-3) of hamadryas baboons with haematosarcoma were presented by analogous lymphoid type cells of a high proliferative activity. the modal class of cells in all the three lines was presented by diploids and pseudodiploids, though there was a significant admixture of heterodiploid and subtriploid cells and cells having various types of marker chromosomes. the reconstructed chromosome 1 and satellite chromosomes dominate ...1977407685
[comparative characteristics of corticosteroid metabolism in lower simians and man].corticosteroid metabolism has been investigated in macaca mulatta, papio hamadryas, cercopithecus aethiops, erithrocebus patas and man. similar character of corticosteroid metabolism in monkeys and man was found. significant interspecific differences with respect to quatitative and qualitative parameters of the metabolism of steroid hormones were found. in this respect m. mulatta and p. hamadryas are most similar to man as compared with other monkeys. these two species may be used as an adequate ...1977409003
[duration and intensity of postvaccinal immunity to plague in experimental animals].experiments were conducted on guinea pigs and papio hamadryas; it was shown that a reduction of the intensity of postvaccinal immunity occurred at various periods after a single vaccination. in inhalation method of immunization in guinea pigs it decreased in 6 months 135 times, in monkeys in one year--133 times. however, at the mentioned periods vaccination provided protection of 50% of the animals from infection with past. pestis in a dose constitutin 20 to 25 aerosol ld50 for nonimmunized anim ...1977409008
the chromosomal location of rdna in selected lower primates.hybridization in stiu was used to identify the chromosomes that carry rdna in representative lower primates, including the baboons, papio cynocephalus and papio hamadryas; the colobus monkey, colobus polykomos; the tree shrew, tupaia glis; the lemur, lemur fulvis; the saki, pithecia pithecia; the marmoset, saguinus nigricollis, and the spider monkey, ateles geoffroyi. the marker chromosome, common to the cercopithecines studied to date, carries the rdna in the baboons. another marker chromosome ...1977414888
[frequency of radiation-induced exchanges in easily identifiable monkey chromosomes].frequency of asymmetric exchanges of readily identifiable chromosomes 1, 2, 3, 4, 8, 9 ad 20 was studied in primary kidney cell cultures of monkeys. macaca mulatta and papio hamadryas irradiated with 200 r of x-rays at g0. the chromosomes studied enter asymmetric exchange in accordance with their lengths of mitosis. the frequency of exchanges is independent of the quantity of late-replicating heterochromation in chromosomes. the radiosensitivity of chromosomes was identical in the two monkey spe ...1979552663
[postcoital contraception in primates. i. action mechanism of a potential postovulatory fertility-inhibiting substance sts 456 in the baboon (papio hamadryas)].with the substance sts 456, an estrogenic active steroid, a high fertility inhibition could be obtained in the pavian, when administered p. o. over a 5 day period postcoital. the effectiveness and also the side effects were dose dependent. the antifertility mechanism is based on an luteolytic effect, demonstrated by analytical hormonal investigations. the inhibition of the synthesis of steroids in the ovary affected not only progesterone but also the estrogens.1978654663
[lung tissue alterations following experimental infection of mice with acholeplasmae isolated from simians with hematosarcoma].this paper is devoted to the study of pathogenic acholeplasmae potencies. two strains of acholeplasmae isolated from the blood and organs of papio hamadryas suffering from hemoblastosis and a standard ach. laidlawii a. strain were subjected to the comparative study with the use of a "pulmonary model" in experiments on mice. morphological investigations showed affections of the pulmonary tissue characterized by stage-by-stage inflammatory-destructive changes analogous to the lesions found in "myc ...1978665035
chemotherapy of helminthiasis among wild mammals. iv. efficacy of flubendazole 5% (r17889) against trichuris trichiura infection of baboons, papio hamadryas l.flubendazole 5%, a parafluor analog of benzimidazole derivative, mebendazole, was found efficient in eliminating trichuris trichiura infection of baboons when administered orally at a dose rate of 27 to 50 mg of the active ingredient per kg body weight twice daily for five days. the drug was found safe, without toxic effects and its palatability was excellent.1978754549
polymorphism of the ca-i locus of carbonic anhydrase in baboon.polymorphism of erythrocytic carbonic anhydrase was studied by means of the usual technique of starch gel electrophoresis in papio papio, papio hamadryas, papio cynocephalus and papio anubis. in a sample containing both papio cynocephalus and papio anubis, examples of the homozygote ca-ib/ca-ib were found. a study of parental transmission established the ca-ib allelic form.1975804560
possible ways viral leukemia spreads among the hamadryas baboons of the sukhumi monkey colony.leukemia virus transmission was studied during an outbreak of leukemia among the baboons of the sukhumi monkey colony. first, the possibility of "vertical" transmission of the virus was examined, as the papio stock in sukhumi was genetically homogeneous. "vertical" transmission of the virus from a common ancestor seems unlikely, since cases of leukemia were registered in animals descending from different families. however, there were cases of innate leukemia, when babies born from leukemic paren ...1975809037
field observation of a birth in hamadryas baboons.a birth in hamadryas baboons was observed during an 18-month field study in ethiopia. the behavior of the birth-giving female and the members of her harem unit are described.1976821828
the establishment of continuous lymphoblastoid suspension cell cultures from hematopoietic organs of baboon (papio hamadryas) with malignant lymphoma.two continuous suspension lymphoblastoid cell cultures designated as spg-1 and kmpg-1 have been established from the bone marrow and spleen cells of the hamadryas baboon no. 9386 with malignant lymphoma. virus particles morphologically characterized as herpes-like have been revealed in kmph-1 and spg-1 cultures in 2-10% of cells. the paper describes the establishment of these suspension cultures.1975823042
urinary steroid excretion and conjugation by the baboon (papio hamadryas)--a comprehensive study. 1976827659
[chromosome band topography of papio hamadryas]. 1976827970
hematologic, biochemical, and physiologic indices of the sacred baboon (papio hamadryas).hematologic, biochemical, and physiologic indices for a recently imported group of sacred baboons, papio hamadryas, were studied over a 6-week period. hematologic values were in agreement with results recorded for other species of baboons. blood biochemical data were consistent with findings previously reported for other baboons and for man except that alkaline phosphatase levels were higher than previously for other baboons but similar to those reported for man; lactic dehydrogenase levels were ...1977857092
high salt intake and blood pressure in lower primates (papio hamadryas).one year of increased salt intake in monkeys elevates mean blood pressure significantly. this effect is more marked in animals exposed just after birth. in animals exposed as adults, the response in males is more pronounced than in females, mainly due to a marked increase of pulse pressure. th hypertensive response was potentiated by reduction of renal mass, which caused gfr values (in terms of body weight) to decrease compared with intact salt-fed animals, in which gfr values were elevated abov ...1976931881
[preparation and comparative evaluation of experimental anthrax diagnostic sera in experiments on animals].the authors present the results of studies on obtaining and comparative assessment of experimental anthrax diagnostic sera in experiments on various animals. donkeys, sheep, horses, rabbits and monkeys (papio hamadryas) were immunized with the sti-i vaccine by a single scheme. the activity of the obtained sera was tested in the diffuse precipitation reaction by the amount of the detected antibodies and the titre. the most active sera were obtained from donkeys and sheep: their titre was 5.5 and ...19751124613
[functional dimorphism in satellite chromosomes in hamadryas baboons].dimorphism of satellite chromosomes observed in bone marrow of female as well as male papio hamadryas, and in continuous cultures of the monkey haemopoetic cells is described. most frequently the observed dimorphism is expressed in different lengths of satellite arms. the structural dimorphism of satellite chromosomes seen in macaca, papio and other genera may seem to originate from different degrees of functional activity of these chromosomes. the active homologue is longer since its satellite ...19751162740
the characterization of polar corticosteroids in the urine of the macaque monkey (macaca fascicularis) and the baboon (papio hamadryas).computerised gas chromatography-mass spectrometry was employed in the identification of polar corticosteroid metabolites excreted in the urine from the macaque monkey (macaca fascicularis) and the baboon (papio hamadryas). the following steroids were identified in significant amounts in the urine from both species: 3alpha,17alpha,20alpha, 21-tetrahydroxy-5beta-pregnan-11-one; 3alpha,17alpha,20beta,21-tetrahydroxy-5beta-pregnan-11-one; 5beta-pregnane-3alpha,11beta,17alpha,20alpha,21-pentol; 5beta ...19751173507
x-linked glucose-6-phosphate dehydrogenase (g6pd) and autosomal 6-phosphogluconate dehydrogenase (6pgd) polymorphisms in baboons.electrophoretic polymorphisms of glucose-6-phosphate dehydrogenase (g6pd) and 6-phosphogluconate dehydrogenase (6pgd) were examined in captive colonies of five subspecies of baboons (papio hamadryas). phenotype frequencies and family data verified the x-linked inheritance of the g6pd polymorphism. insufficient family data were available to confirm autosomal inheritance of the 6pgd polymorphism, but the electrophoretic patterns of variant types (putative heterozygotes) suggested the codominant ex ...19921296572
[the characteristics of the intragroup behavior of rhesus macaques and hamadryas baboons during the realization of food motivation in a competitive situation].the aim of the present work is to consider the specific interrelations in "family" units of macaques (macaca mulatta) and baboons (papio hamadryas) during food-getting reactions in competitive conditions. detailed analysis of dyadic interactions revealed that competing partners demonstrate more various types of behaviour tactics at the initial stage of learning. at the final one, only males of both investigated species performed instrumental reactions and received the food reward. all females de ...20061300021
[effects of chronic surfagon administration on secretion of luteinizing hormone and morphofunctional state of the testes in papio hamadryas].the paper is concerned with the results of a study of the effects of chronic (12 weeks) subcutaneous infusion of surfagon (d-ala6, des-gly10-ethylamide of lh-rh, a daily dose of 3 micrograms/kg of body mass) using osmotic mini-pumps on hormonal function of the hypophyseogonadal system, spermatogenesis and testicular histology in experiments on papio hamadryas. prolonged infusion of surfagon through short-term transient activation of the hypophyseogonadal system was shown to cause inhibition of t ...19921308599
endometriosis and stromal tumor in a baboon (papio hamadryas). 19921318457
detection and characterization of t-cell leukemia virus-like proviral sequences in pbl and tissues of baboons by pcr.the "high lymphoma-prone" baboon stock (papio hamadryas) of the sukhumi primate center colony is characterized by a high prevalence of antibodies to the stlv-i/htlv-i type of retrovirus and a high manifestation of human atl-type (adult t-cell leukemia/lymphoma) malignancies (yakovleva et al., this symposium). this is in contrast to other primate colonies and wild monkeys, which have low seroprevalence and very few if any atl-type t-cell malignancies. to characterize the type of t-cell lymphoma r ...19921318468
[the comparative action of relanium and oxytocin on higher nervous activity in lower monkeys].effects of relanium and oxytocin on higher nervous activity was studied in four rhesus monkeys (macaca mulatta) and two baboons (papio hamadryas). during observation of the animals in enclosure tranquilizing effect was seen only after relanium administration. under the same conditions oxytocin practically did not change the general behaviour pattern of monkeys. however, steady behavioural transformations were observed under the conditions of competitive food-procuring behaviour and during the op ...19921332292
[spontaneous and experimental hepatitis a in papio hamadryas].data on high susceptibility of papio hamadryas to hav are presented. for the first time, p. hamadryas were shown to be able to respond to both natural and experimental infection developing the features typical of hepatitis a: increased aminotransferase activity, virus shedding in feces, production of anti-hav igg and igm, histological liver lesions. an infection lingering for 3-4 months was observed, as well as a case of chronic experimental hepatitis a with relapse in 7 months of the disease. v ...19921335190
inhibitory and excitatory amino acid receptors, c-fos expression, and calcium-binding proteins in the brain of baboons (papio hamadryas) that exhibit 'spontaneous' grand mal epilepsy. 19921363039
[stress-inducing behavioral changes and the functions of the neurohormonal systems in monkeys of different social ranks].as a result of intensive stressful stimuli hamadryas baboons developed, depending on their hierarchic status, depression-like states varying in severity. their development correlated with a drastic release of biogenic amines, activation of pituitary-adrenal system and inhibition of hormonal function of the gonads. it is shown that dominant and low-rank monkeys, in spite of the differences in their initial psychoemotional states and in the blood levels of mediators and hormones, demonstrated mark ...19921363277
baboon t cell lymphomas expressing the b cell-associated surface proteins cd40 and bgp95.papio hamadryas baboons in the sukhumi colony develop enzootic outbreaks of malignant lymphomas with an incidence of about 1.5% per year among adults of the high-risk stock. we investigated the surface phenotypes of cells from normal and lymphomatous animals using antibodies against human lymphocyte antigens. we found that more than 80% of the lymphomas that developed during the last 3 years were characterized histologically to be of the peripheral t cell type. generally, the lymphomatous cells ...19921383259
[relationship between functional activity of the adrenal glands and gonads in monkeys during puberty].testicular and adrenal cortex endocrine functions were simultaneously tested in pubertal baboons (papio hamadryas) during one year. concentrations of androgens (testosterone, 5 alpha-dihydrotestosterone, dehydroepiandrosterone), corticosteroids (cortisol, progesterone, 17-hydroxyprogesterone, 17-hydroxypregnenolone) and aldosterone were determined in blood of the experimental monkeys by radioimmunoassay. it was shown that with increasing androgen (testosterone and dihydrotestosterone) levels in ...19921421246
[the opsonizing activity of the sera of hamadryas baboons immunized with a preparation of the outer membranes of francisella tularensis (based on data from the luminol-dependent luminescence method)].the opsonizing properties of sera obtained from hamadryas baboons immunized with the preparation of f. tularensis outer membranes (om) were studied with the use of luminol-dependent chemiluminescence (cl) of whole blood. the immunization of monkeys with the om preparation was shown to lead to the formation of functionally active antibodies possessing opsonizing properties with respect to virulent f. tularensis. immune sera obtained from the animals immunized with live vaccine and from those immu ...19921496878
a comparative study of natural killer cell activity, lymphoproliferation, and cell phenotypes in nonhuman primates.three different species of nonhuman primates (baboons [papio hamadryas], rhesus monkeys [macaca mulatta], and african green monkeys [cercopithecus aethiops]) were evaluated for their natural killer cell activity, and for the ability of their peripheral blood mononuclear cells to proliferate in response to known mitogens (concanavalin a, phytohemagglutinin, and pokeweed mitogen) and to react with a panel of mouse monoclonal antibodies directed against human leukocyte surface antigens. rhesus monk ...19921557864
[regeneration of the function of the hypophyseal-gonadal system after its prolonged suppression with luliberin agonists].the paper is concerned with the results of investigation into the nature of regeneration of function of the hypophyseo-gonadal system in 15 mature male papio hamadryas, subjected to infusion of lh-rh agonists (buserelin, hoechst a. g. germany) and surfagon (all-union cardiology research center, ussr) using osmotic mini-pumps (alzo corp., palo alto, usa) for 5-16 weeks. regeneration of this system was characterized by 3 main phases: latent; gonadal hyperfunction and return to the basal level of f ...20161658774
[effect of corticoliberin and naloxone on the functional activity of the hypophyseal-gonadal system in monkeys].experiments were staged on male papio hamadryas for a study of crf and naloxone action on the time course of lh and testosterone in peripheral blood. lh was determined by a biological micromethod in vitro; acth, cortisol and testosterone were determined by radioimmunoassays. exogenous crf was shown to increase inhibitory action of acute "procedure" stress (frequent fixation of monkeys and venipuncture for taking blood samples) of the secretion of lh but not testosterone. opioid preceptor blockad ...19911658776
immunohistochemical study on the localization of the epitope defined by a human saliva-specific mouse monoclonal antibody (p4-5c).a novel mouse monoclonal antibody (p4-5c) has been developed which recognizes the core portion of the protein carrying abo(h) blood group antigens in human saliva. this proved to be specific for human saliva using immunochemical investigations such as enzyme-linked immunosorbent assay, ouchterlony method and counter-immunoelectrophoresis. by light and electron microscope studies with immunohistochemical techniques using this human saliva-specific p4-5c as primary antibody, it was shown that p4-5 ...19911716968
cytoarchitecture and intrafrontal connections of the frontal cortex of the brain of the hamadryas baboon (papio hamadryas).a study was made of the cytoarchitecture of the lateral and medial frontal cortex in the hamadryas baboon (papio hamadryas). the frontal cortico-cortical connections of areas 46, 8, 6, and 4 were investigated by injection of wheat-germ agglutinine conjugated to horseradish peroxiase (wga-hrp) into different regions of areas 46, 8, and 6. the lateral region of the frontal lobe of the baboon consists of broad areas of motor (area 4), premotor (area 6), and the dorsolateral prefrontal cortex, each ...19911719042
linkage of plasminogen (plg) and apolipoprotein(a) (lpa) in baboons.four allelic forms of serum plasminogen (plg) were detected in baboons (papio hamadryas linneaus 1758) by isoelectric focusing and were determined to be inherited as autosomal codominant traits. linkage analysis of data from 179 progeny and their parents revealed that plg is tightly linked (lod score = 30.20) to the gene encoding apolipoprotein(a) (lpa), as in humans. no recombinant individuals were identified. this is the first linkage detected between plg and lpa in any species other than huma ...19911783400
microscopic anatomy of the baboon (papio hamadryas) adrenal medulla.adrenal medullas of 2 baboons perfused with formaldehyde/glutaraldehyde and tannic acid were studied by light and electron microscopy. tissues were postfixed in oso4. this procedure allows identification of noradrenaline cells on the basis of a selective reaction of glutaraldehyde with noradrenaline vesicles. as positive control for noradrenaline cells, similarly treated mouse adrenal medullas were also examined. light microscopic examination of thick sections of baboon medullas did not show nor ...19911810929
integrating behavior and cardiovascular responses: the code.the next revolution in biology is predicted to be in the integrative domain, and the need to involve physiologists in this kind of research has been recognized. this paper represents an approach to providing some of the tools required for dealing with integrative physiology at the behavioral level. video tape recordings are made of the activities of a group of five baboons (papio hamadryas) while simultaneous recordings of arterial blood pressure, heart rate, renal blood flow, and mesenteric or ...19911858945
[the use of microdot immunoenzyme analysis with visual detection for the determination of tularemia antibodies].the possibility of using the micropoint enzyme immunoassay (eia) on a nitrocellulose membrane with the visual evaluation of results for the detection of tularemia igg antibodies in hamadryas baboons at the postvaccinal period has been studied. the sensitivity of this assay has been compared with that of the passive hemagglutination (pha) test, the microagglutination (ma) test and eia with the spectrophotometric evaluation of results in plates. as shown in this study, eia in the above-mentioned m ...19911872100
[experimental lassa fever in hamadryas baboons].intramuscular or aerogenic inoculation of baboons with lassa virus reproduced a severe form of the disease which clinically, pathoanatomically and virologically resembles the severe form of human lassa fever reported in the literature. the severity of monkey infection is demonstrated by rapid development of symptoms of general toxicity in the presence of fever, manifestations of hemorrhagic diathesis, high level of viremia and isolation of the causative agent from nasopharyngeal washings.19911882523
[the characteristics of the antibody response of animals immunized with components of the surface structures of francisella tularensis].antibody formation in animals immunized with one of the components of f. tularensis surface structures was studied. the time course of antibody formation in 20 hamadryas baboons was studied in the passive hemagglutination (pha) test, microagglutination (ma) test, and indirect enzyme immunoassay, used for the determination of igg, iga and igm antibodies. the character of antibody response in the animals immunized with components of f. tularensis surface structures (s-complex) and with live tulare ...19911950288
[comparative analysis of genomes of oncogenic b-lymphotropic herpesviruses reproducing in cell lines obtained from different monkey species].the aim of this work was to study genomes of b-lymphotropic oncogenic herpesviruses of macaca arctoides (hvma), papio hamadryas (hvp) and cercopithecus aethiops (hvgm). blot-hybridization detected inter- and intraspecific genome heterogeneity of investigated viruses in restriction sites ecor1, pst1 and hind111. virus-specific sequences in two-cell lines obtained from hvma-induced rabbit tumours can prove hvma a role in malignant tumour induction in rabbits.19901964615
variation in lp(a) levels and apo(a) isoform frequencies in five baboon subspecies.elevated levels of lipoprotein (a) [lp(a)] are positively correlated with risk of cardiovascular disease and are thought to be a function of allelic variation in apo(a), the unique protein component of lp(a). in this article we examine subspecies variation in lp(a) levels and apo(a) isoforms in the baboon. breeding populations of the five subspecies (papio hamadryas hamadryas, p.h. cynocephalus, p.h. ursinus, p.h. papio, and p.h. anubis) of common long-tailed baboons are maintained at the southw ...19912004745
infectivity of trypanosoma (trypanozoon) brucei gambiense for baboons (papio hamadryas, papio papio).in order to study sensitivity or resistance of t.b. gambiense to baboon serum, two species of baboons, p. hamadryas and p. papio were inoculated with t.b. gambiense clone litat 1.1. both species were receptive to infection but, parasitological and immunological parameters showed that p. papio was more trypanotolerant than p. hamadryas. the vat-specific trypanolysis test and the elisa, using moab for circulating antigen detection may be appropriate for the diagnosis of human trypanosomiasis due t ...19912042999
[the postvaccinal reaction in hamadryas baboons to the administration of attenuated strain 15 of the venezuelan equine encephalomyelitis virus].immunization of papio hamadryas with attenuated vee virus (strain 15) causes seroconversion in 100% of animals. postvaccinal reaction such as viremia and short-lasting fever occurs in response to the injection of 10(3) imd50 in about 30% of animals. cns lesion symptoms characterizing infection of papio hamadryas with natural trinidad strain do not occur in response to injection with attenuated strain.19912054507
[infanticide in hamadryas baboons].the results of 20-year study of infanticide cases in hamadryas baboon troop of the sukhumi colony and 10-year observations in gumista natural reserve are presented. the allopatric behaviour which may be the cause of infant death, is shown to be common for 4-7 year old males. in behaviour of older males directed to the infants the elements of aggression predominate. the majority of injuries and infanticide by males takes place in the situations associated with a dominant male change in the group ...19902142606
[the role of acth in regulating dehydroepiandrosterone secretion in primates].the effect of repeated administration of a prolonged acth agent on the secretion of glucocorticoids, dehydroepiandrosterone (dea) and delta 4- and delta 5-precursors was studied in experiments on male hamadryas baboons. the administration of sinacten-depot at a dose of 1 mg for 5 days caused a noticeable decrease in the basal levels of cortisol, 11-deoxycortisol, pregnenolone, 17-oxypregnenolone, and dea. response of the adrenal glands to additional acth stimulation against a background of lower ...20162158657
production of baboon (papio hamadryas) monoclonal antibodies by herpesvirus papio immortalized baboon lymph node cells.baboon monoclonal antibodies specific for monomorphic determinants of baboon apolipoprotein b were produced from in vivo primed lymph node cells immortalized by herpesvirus papio (hvp). two cell lines from the immortalized cells were readily stabilized and grew rapidly. since epstein-barr virus (ebv) cannot be used to immortalize baboon or macaque cells, hvp expands the potential sources of monoclonal antibodies to include baboons, and is the immortalizing agent of choice for macaques as well.19902303734
highly polymorphic apolipoprotein a-iv locus in the baboon.apolipoprotein a-iv is found in mesenteric lymph chylomicrons, very low density lipoprotein particles, high density lipoprotein particles, and in the lipoprotein-free fraction of plasma. apolipoprotein a-iv is polymorphic in a variety of species including human, dog, and horse. efforts to estimate the impact of apolipoprotein a-iv structural variation on quantitative lipid levels in humans have been limited by the low frequency of the less common alleles. in the baboon, papio hamadryas anubis, w ...19902313197
an outbreak of botulism in captive hamadryas baboons (papio hamadryas). 19902316161
[hormonal reaction of steroid-producing glands of female papio to long-term hypokinesia].the endocrine function of steroid-producing glands of hamadryas baboon females exposed to 28-day clinostatic hypokinesia at different stages of the menstrual cycle was investigated. the adrenocortical response to hypokinesia developed in two phases: early stimulation was followed by inhibition of the adrenocortical activity which persisted during the subsequent period of hypokinesia and two weeks after exposure. the degree and duration of the activation effect of hypokinesia were determined by t ...20132366502
gastric haemorrhage and perforation caused by a trichobezoar in a baboon (papio hamadryas).a captive-bred male baboon presented with severe evidence of blood loss and melaena. an upper gastrointestinal radiological study with gastrografin showed a large trichobezoar. laparotomy confirmed its presence and revealed gastric ulceration with perforation and generalized peritonitis. the condition was successfully treated by surgery.19762366517
hemodynamics of conscious unrestrained baboons, including cardiac output.a method is described for comprehensive hemodynamic study of undisturbed baboons (papio hamadryas) that incorporates cardiac output measurement by thermodilution. instrumentation includes arterial, aortic, and central venous catheterization by a surgical technique that does not require entry to peritoneal or thoracic cavities. it provides a means for right atrial indicator delivery with aortic temperature recording of thermodilution curves. accuracy was confirmed by comparison to measurement by ...19902384419
antigenic properties of human and animal bloodstains studied by enzyme-linked immunosorbent assay (elisa) using various antisera against specific plasma proteins.antigenic properties of bloodstains of human and non-human primates as well as other animal bloodstains were investigated by the inhibition elisa using commercially available anti-human albumin (alb), alpha 2-macroglobulin (alpha 2-m), fibrinogen, transferrin, and immunoglobulin g. in general, chimpanzee bloodstains showed strong cross-reactions with these antisera, and the extent of the cross-reactions of other animal bloodstains decreased largely with the phylogenic order, i.e., agile gibbon ( ...19872448970
[polymorphism of the response of the hypophyseo-gonadal system to the long-term administration of an agonist of luliberin].the paper is concerned with the results of experiments on male papio hamadryas aimed at the investigation of their hypophyseal and gonadal endocrine function by intravenous drip with the help of subcutaneously implanted osmotic mini-pumps of buzerelin, a superactive lh-rh analog. a 2-phase response of the hypophyseal-gonadal system was revealed. the stimulation of the secretion of lh and testicular androgens in the first 5-7 days of buzerelin administration was followed by sharp suppression of g ...20162500654
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