Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| marmoset species variation in the humoral antibody response: in vivo and in vitro studies. | a comparison of the in vivo and in vitro antibody response capabilities of two marmoset species, saguinus fuscicollis and saguinus oedipus oedipus, revealed the former to be superior in elaborating humoral antibody. in vivo challenges with escherichia coli lipopolysaccharide (lps) and salmonella typhi flagella consistently yielded higher antibody titres in s. fuscicollis; indeed, with lps antigen, multiple inoculations of s.o. oedipus marmosets led ultimately to a decrease in antibody formation, ... | 1978 | 100417 |
| chromosome banding patterns and nucleolar organizing regions in three species of callithricidae (saguinus oedipus, saguinus fuscicollis, and callithrix jacchus). | chromosome complements of three species of callithricidae, saguinus oedipus, saguinus fuscicollis and callithrix jacchus, were analyzed by various banding techniques. morphometric data are presented. a diploid chromosome number of 2n = 46 is reconfirmed for all three species. several interesting interspecies chromosomal variations were demonstrated by g- and c-band patterns. active nucleolar organizing regions (nors) were revealed by the ag-as silver histochemical stain. | 2000 | 101664 |
| product-inhibition of testicular steroidogenic enzymes in the marmoset saguinus oedipus. | 1999 | 116088 | |
| corynebacterium equi in the cottontop marmoset (saguinus oedipus): a case report. | a wild-caught cottontop marmoset died after a short illness characterized by loss of appetite, loss of weight and general unthriftiness. necropsy revealed a large thoracic abscess from which corynebacterium equi was recovered. | 1979 | 117222 |
| the use of time and space by the panamanian tamarin, saguinus oedipus. | tamarin activity patterns and habitat utilization strategies in the tropical dry forest of the panama canal zone were monitored quantitatively using radio-location telemetry. the daily tamarin activity pattern differed from that of other neotropical primates in that early morning and late afternoon activity normally did not occur. total daily activity time averaged 676 +/- 62 min. sleeping trees, and behaviors associated with their use, were documented. daily path length averaged 2,061 +/- 402 m ... | 1979 | 118902 |
| indoor-outdoor housing systems for a self-sustaining marmoset breeding colony. | indoor-outdoor housing of three types was designed, constructed, used and evaluated for housing a breeding colony of common (callithrix jacchus) and cottontop (saguinus oedipus) marmosets. all types were relatively inexpensive to construct, required minimal care, simulated a natural environment and allowed for some isolation between units and between individual runs within units. | 1979 | 119116 |
| tetrapetalonema (t.) panamensis (mccoy, 1936) comb. n. (filarioidea: onchocercidae) in colombian primates, with a description of the adults. | microfilaria panamensis mccoy, 1936 was identified in the blood of cebus apella, c. capucinus, c. albifrous, and saguinus oedipus from various regions in colombia. adult worms, recovered from the subcutaneous connective tissues of c. apella and s. oedipus, were identified with this microfilaria and are described as tetrapetalonema (t.) panamensis (mccoy, 1936) comb. n. this nematode is smaller configuration of the female tail and in the appearance of the spicules, and t. barbascalensis which dif ... | 1979 | 120436 |
| the chemotactic, phagocytic, and microbial killing abilities of primate polymorphonuclear leukocytes (pml). | functions of polymorphonuclear leukocytes including chemotaxis, phagocytosis, and microbial killing were investigated in baboons (papio cynocephalus), cebus monkeys (cebus apella), and marmosets (saguinus oedipus). cells from a group of normal adult human volunteers were also studied for comparison. polymorphonuclear leukocytes from the three nonhuman primate species were comparable to each other and to humans in chemotactic activity using endotoxin activated serum. in addition, the ability of b ... | 1979 | 121031 |
| metabolism of pregnenolone and progesterone by testicular microsomes of the baboon papio anubis and the marmoset saguinus oedipus. | 1979 | 159981 | |
| type-c virus particles in placenta of the cottontop marmoset (saguinus oedipus). | electron microscopy of near-term placentas of two cottontop marmosets (saguinus oedipus) revealed, in one placenta, the presence of budding and mature c-type virus particles associated with the basal trophoblast. the particles were morphologically similar to those observed by other investigators in placentas of other primate species. | 1996 | 163321 |
| lymphoma in cotton-top marmosets after inoculation with epstein-barr virus: tumor incidence, histologic spectrum antibody responses, demonstration of viral dna, and characterization of viruses. | 6 of 20 cotton-top tamarins (saguinus oedipus) inoculated with epstein-barr virus (ebv) developed diffuse malignant lymphoma resembling reticulum cell or immunoblastic sarcoma of man. hyperplastic lymphoreticular lesions were induced in three additional animals; in two instances the hyperplastic lesions regressed. inapparent infection with development of antibody occured in eight animals. in two animals there was no evidence of ebv infection. one animal died in the first week after inoculation o ... | 1977 | 192829 |
| studies with the baboon endogenous virus and its pseudotype of murine sarcoma virus in marmosets. | three marmoset species (saguinus oedipus oedipus, s. fuscicollis, callithrix jacchus) failed to show evidence of infection or disease following inoculation of baboon endogenous type-c virus (baev). cells infected with a kirsten murine sarcoma-baev pseudotype (msv[baev]) produced a progressive fibrosarcoma in s. o. oedipus and tumors in s. fuscicollis and c. jacchus which regressed. tumor formation is believed to be due to growth of inoculated, virus-infected cells and not transformation of marmo ... | 1978 | 205851 |
| overview of viral oncology studies in saguinus and callithrix species. | marmoset monkeys are highly susceptible to tumor induction by type c sarcoma viruses and primate lymphotropic herpeviruses. six experimental models were reviewed, three sarcoma models induced by rous, feline or simian sarcoma viruses and three models of lymphoproliferative disease induced by herpevirus saimiri, h. ateles or epstein-barr virus. relative susceptibility of cotton-topped (saguinus oedipus oedipus), white-lipped (s. nigricollis, s. fuscicollis subspecies) and commone (callithrix jacc ... | 1978 | 205860 |
| further characterization of a herpesvirus-positive orang-utan cell line and comparative aspects of in vitro transformation with lymphotropic old world primate herpesviruses. | an orang-utan (pongo pygmaeus) suspension line, cp81, was shown to lack myeloid markers of lysozyme activity an d phagocytosis but to be positive for lymphocytic n-alkaline phosphatase activity, and to release a b-cell-tropic herpesvirus. this herpesvirus, termed herpesvirus pongo, had 30--40% dna homology with ebv and was present at 2-3 genome copies per cp-81 cell. gibbon lymphocytes transformed by h. pongo, epstein-barr virus (ebv), and h. papio (of baboon, papio hamadryas, origin) were found ... | 1978 | 208990 |
| seroconversion against epstein-barr virus in two nonhuman primate species infected by the oropharyngeal route. | transforming epstein-barr virus (ebv) was inoculated into eight squirrel monkeys (saimiri sciureus) by spraying of viral concentrates into the nose and throat. virus was inoculated into three marmosets (two saguinus oedipus and one calithrix jacchus jacchus) by direct injection into nasopharyngeal tissue. two of these squirrel monkeys seroconverted after repeated inoculation as determined by the presence of ebv-specific antibodies to early antigen and viral capsid antigen. one squirrel monkey ha ... | 1978 | 213505 |
| isolation of a cytomegalovirus from salivary glands of white-lipped marmosets (saguinus fuscicollis). | minced salivary glands from seven white-lipped marmosets (saguinus fuscicollis and saguinus nigricollis) and one cotton-topped marmoset (saguinus oedipus) were cocultivated with marmoset cell cultures. a viral agent, designated ssg, was isolated from two saguinus fuscicollis. slowly progressing foci of rounded, vacuolated, refractile cells were first observed at 40-43 days incubation. electron microscopy revealed intranuclear herpesvirus nucleocapsids and intracytoplasmic and extracellular envel ... | 1979 | 220464 |
| fatal herpesvirus tamarinus infection in cotton-topped marmosets (saguinus oedipus). | fatal herpesvirus tamarinus infection was observed in cotton-topped marmosets (saguinus oedipus) imported from south america via the united states on august 26, 1976. in addition to the lesions hitherto reported in herpesvirus tamarinus infection, severe degenerative and necrotic changes of ganglion cells were recognized with intranuclear inclusion bodies in the plexus of the digestive tract and the sympathetic nerves and their ganglions in the abdominal cavity. inflammatory or regressive change ... | 1979 | 230986 |
| [spontaneous infection of marmoset-monkeys (sanguinus oedipus) with a trypanosoma cruzi-like-strain, springer 1975. isolation and identification (author's transl)]. | a trypanosoma cruzi-like strain was isolated from marmoset monkeys originating from columbia. the frequency of affected monkeys was up to 32.7%. the parasite density was 10-40 trypomastigote forms per mililiter. monkeys, rats, mice and other small rodentia were found to be susceptible. clinical symptoms or histopathological findings could not be acertained with these trypanosomes even after a 2 1/2 year observation period. the strain behaved as an apathogen in experimental animals. the parasitae ... | 1977 | 416623 |
| spontaneous colonic adenocarcinoma in marmosets. | we find that colonic adenocarcinoma, which is an extremely rare neoplasm of all animals except man and carcinogen-treated rodents, occurs spontaneously in some marmosets. the cotton-topped saguinus oedipus oedipus is particularly prone to develop it, but we have found it also at necropsy in callimico goeldii (goeldi's marmoset). numerous metastases to regional lymph nodes develop. the cancers arise de novo in the mucosa and early invade the submucosa and lymphatic apparatus and paracolonic lymph ... | 1978 | 417316 |
| efferent connections of the orbitofrontal cortex in the marmoset (saguinus oedipus). | unilateral partial ablations were made in the orbitofrontal cortex of 4 adult marmosets (saguinus oedipus) and fiber degeneration was traced using the nauta-gygax and fink-heimer selective silver impregnation techniques. corticocortical projections were found to the ipsilateral convexity and medial aspect of the frontal lobe and to the homologous orbitofrontal areas of the contralateral hemisphere. fiber degeneration was followed through the uncinate fascicle to the temporal and insular cortices ... | 1975 | 803392 |
| a killed vaccine derived from the oncogenic herpesvirus ateles. | a killed herpesvirus vaccine was prepared by inactivation of the oncogenic herpesvirus ateles (hva) with heat and formaldehyde. the vaccine proved safe in 9 marmosets (saguinus oedipus) during a period of 461 days. the vaccinated marmosets developed high titers of serum antibodies against hva and were resistant to 316 lethal dose 50 (ld50) cell-free hva; the nonvaccinated control monkeys died of malignant lymphoma. the 5 challenged monkeys are clinically well and have now been under observation ... | 1975 | 808642 |
| glucose utilization by the salivary glands of the marmoset saguinus oedipus. | glucose utilization by the marmoset salivary glands was studied radioisotopically, both in vitro and in vivo. surgically excised, minced parotid and submandibular glands from 7 adult animals were incubated in vitro in a medium containing uniformly labeled 14c glucose (glucose-ul-14c), then subjected to respirometry measurements and to extraction and separation procedures for the radioautographic isolation and identification of amino acids, organic acids, and glucose. glucose utilization in vivo ... | 1975 | 821167 |
| pathway of testosterone biosynthesis in the testis of the marmoset saguinus oedipus. | these studies were undertaken to determine the principal pathway of androgen biosynthesis by the testis of the marmoset saguinus oedipus. testicular fragments (25 mg) were incubated at 37 degrees c in krebs-ringer bicarbonate buffer, ph 7.4, containing pregnenolone-7-3h (3beta-hydroxy-5-pregnen-20-one) or progesterone-7-3h. duplicate fragments were incubated with each substrate for 30 min, one hr, three hr, or five hr, for a total of 16 separate incubations. metabolites were separated by paper a ... | 1976 | 827826 |
| reproductive characteristic of free-ranging panamanian tamarins (saguinus oedipus geoffroyi). | field observations on reproductive activity in the panamanian tamarin (saguinus oedipus geoffroyi) were made in conjunction with the examination of 131 reproductive tracts collected at regular intervals over one year. reproductive tract characteristics were compared over seasons. embryonic and fetal development were also assessed. a distinct birth peak was observed from april to early june. pregnancies in april and may point to a potential, but unrealized, birth peak in august and september. des ... | 1976 | 828669 |
| protective immunization against epstein-barr virus-induced disease in cottontop tamarins using the virus envelope glycoprotein gp340 produced from a bovine papillomavirus expression vector. | inoculation with epstein-barr virus (ebv) induces malignant lymphomas in the cottontop tamarin (saguinus oedipus oedipus). this provides an experimental animal model for assessing the efficacy of candidate ebv vaccines which are intended to reduce the incidence of human tumours associated with ebv infection. previous work has shown that experimental vaccines based on the major virus envelope glycoprotein gp340 prepared from the membranes of ebv-infected cells are effective in protecting cottonto ... | 1992 | 1311367 |
| features of female reproductive senescence in tamarins (saguinus spp.), a new world primate. | cyclical changes in concentration of plasma progesterone, urinary oestrone-conjugates and urinary luteinizing hormone (lh) were compared in young and older cotton-top tamarins (saguinus oedipus) and saddle-backed tamarins (s. fuscicollis). a group of six young adult tamarin females (4-5 years of age) was sampled over eight periods of 6-8 weeks and six older (14-20 years of age) females were sampled over thirteen periods. there was hormonal evidence of ovulation in all of the sampling periods for ... | 2005 | 1317448 |
| responses of isolated japanese monkey tracheal muscle to allergic mediators. | the responsiveness of isolated japanese monkey (macaca fuscata) tracheal muscle to antigen, carbachol, histamine, leukotriene c4 (ltc4), u-46619 and substance p (sp) was compared to that of isolated human trachea. weak but persistent contraction was observed after the addition of antigen to isolated japanese monkey tracheal muscle passively sensitized with monkey serum containing ige antibody against japanese cedar (cryptomeria japonica) antigen. unlike monkey tracheal muscle, a fair amount of c ... | 1992 | 1378043 |
| expression of vascular adhesion molecules in inflammatory bowel disease. | the expression of the vascular adhesion molecules elam-1 (endothelial leukocyte adhesion molecule 1) and vcam-1 (vascular cell adhesion molecule 1) was evaluated in colonic mucosa of patients with inflammatory bowel disease and normal controls by immunocytochemistry. vcam-1 was found to be constitutively expressed in lymphoid aggregates in normal colonic mucosa and was not significantly enhanced or altered in distribution in mucosa of patients with inflammatory bowel disease regardless of the ac ... | 1992 | 1379955 |
| in vitro characteristics of yersinia pseudotuberculosis of nonhuman primate origin. | six strains of serotypes 1 or 2 of y. pseudotuberculosis were isolated from dead squirrel monkeys, a cotton-top tamarin and a marmoset hybrid. all strains harboured a 71.6 kb plasmid, all were totally oxacillin-resistant and partially resistant to cephalosporins. biochemically, serotypes 1 and 2 differed from each other in their beta-galactosidase production in a nonfermenter system, whereas the lack of rhamnose, maltose, salicin and trehalose fermentation seemed to be attributable to technical ... | 1992 | 1486229 |
| systematics of the saguinus oedipus group of the bare-face tamarins: evidence from facial morphology. | the systematics of the saguinus oedipus group within the bare-face tamarins remains open to question. hershkovitz (living new world monkeys (platyrrhini), vol.1. chicago: university of chicago press, 1977) places the cotton-top and rufus-naped tamarins as subspecies of saguinus oedipus (s. o. oedipus and s. o. geoffroyi, respectively). in contrast, several other authors have argued that these two taxa should be considered separate species (s. oedipus and s. geoffroyi). phylogenetic relationships ... | 1992 | 1530063 |
| corpus callosum in sexually dimorphic and nondimorphic primates. | the midsagittal area and other morphological measures were taken on the corpus callosum of four different species of primate: macaca mulatta, m. fascicularis, callithrix jacchus, and saguinus oedipus. the first two species are strongly dimorphic, whereas the new world forms show little dimorphism with regard to overall body size, canines, and brain weight. neither total corpus callosal area (totalcc), or other parts of the corpus callosum (cc) showed any significant sexual dimorphism in any of t ... | 1992 | 1562061 |
| ulcerative colitis-linked antineutrophil cytoplasmic antibody in the cotton-top tamarin model of colitis. | the presence of antineutrophil cytoplasmic antibodies (anca) in serum has recently been shown to be a good disease marker for ulcerative colitis. an animal model of colitis expressing serum anca would allow prospective studies of the relationship between anca expression and development of colitis. the cotton-top tamarin model of spontaneous colitis was investigated for presence of anca to evaluate its potential as a model for the study of the immune response in human ulcerative colitis. results ... | 1992 | 1568559 |
| major-histocompatibility-complex drb genes of a new-world monkey, the cottontop tamarin (saguinus oedipus). | the drb region of the human and great-ape major histocompatibility complex displays not only gene but also haplotype polymorphism. the number of genes in the human drb region can vary from one to four, and even greater variability exists among the drb haplotypes of chimpanzees, gorillas, and orangutans. accumulating evidence indicates that, like gene polymorphism, part of the haplotype polymorphism predates speciation. in an effort to determine when the gene haplotype polymorphisms emerged in th ... | 1992 | 1584011 |
| survey of saguinus mortality in a zoo colony. | six years of necropsy records from a zoo colony of four tamarin species (saguinus oedipus, s. geoffroyi, s. imperator, and s. mystax) were examined. mean age at death was 4.0 years, average length in the colony at time of death was 3.4 years. annual mortality rate varied between 9 and 30%. gross necropsy findings, histopathologic, and bacteriological results indicate primary cause of death as follows: peritonitis (26%), septicemia (14%), nephritis (5%), hepatitis (5%), pneumonia (2%), and others ... | 1992 | 1602456 |
| experimental colitis in animal models. | colitis may be induced in animals by oral administration of sulfated polysaccharides (carrageenan, amylopectin sulfate, dextran sulfate), chemical irritation by rectal instillation of diluted acetic acid, delayed hypersensitivity reaction after sensitization to dncb or after one single administration of tnbs, and arthus reaction induced by intravenous injection of immune complexes after chemical irritation of the colon, and by chemoattractant peptides such as fmlp. it appears that all models of ... | 1992 | 1641579 |
| inflammatory mediators in cotton-top tamarins (ctt) with acute and chronic colitis. | spontaneous colitis in ctt's presents cytological characteristics similar to chronic ulcerative colitis in humans, e.g. inflammatory cell infiltrate and crypt abscesses. to better characterize ctt colitis as a potential model for human inflammatory bowel disease (ibd), inflammatory mediators identified in colonic tissue of human ibd patients and/or experimental colitis models were assayed. inflammatory mediator changes in plasma and colon from tamarins with acute (n = 10) and chronic (n = 10) co ... | 1991 | 1665291 |
| mr 40,000 human colonic epithelial protein expression in colonic mucosa and presence of circulating anti-mr 40,000 antibodies in cotton top tamarins with spontaneous colitis. | saguinus oedipus, callithrix jacchus, and saguinus fuscicollis are three species of new world monkeys which develop a form of colitis that is similar to human ulcerative colitis. only s oedipus, however, develop colon cancer. we examined intestinal tissues from these animals for the presence of an antigen cross reacting to the mr 40,000 human colonic epithelial protein that acts as an autoantigen in ulcerative colitis. using an anti-mr 40,000 monoclonal antibody (7e12h12, igm isotype), by an imm ... | 1992 | 1740277 |
| the involucrin genes of the white-fronted capuchin and cottontop tamarin: the platyrrhine middle region. | in all anthropoid species, the coding region of the involucrin gene contains a segment of short tandem repeats that were added sequentially, beginning in a common anthropoid ancestor. the involucrin coding region of each of two platyrrhine species, the white-fronted capuchin (cebus albifrons) and the cottontop tamarin (saguinus oedipus), has now been cloned and sequenced. these genes share with the genes of the catarrhines the repeats added in the common anthropoid lineage (the early region). af ... | 1991 | 1766360 |
| pachyonychia congenita-like disorder in cotton-top tamarins (saguinus oedipus oedipus). | a spontaneous genodermatosis in 13 cotton-top tamarins is described as a retrospective study. the disease appeared as alopecia, pigmentary disturbances, and claw dystrophy similar but not identical to human pachyonychia congenita. the disease in the tamarins seems to be inherited as an autosomal recessive trait, becoming clinically apparent around adolescence. in certain families the neonatal mortality rate was also above average, reaching 100%. | 1991 | 1803010 |
| unusually limited nucleotide sequence variation of the expressed major histocompatibility complex class i genes of a new world primate species (saguinus oedipus). | although major histocompatibility complex (mhc) class i molecules are, as a rule, highly polymorphic in mammalian species, those of the new world primate saguinus oedipus (cotton-top tamarin) exhibit limited polymorphism. we have cloned and sequenced twelve mhc class i cdnas from this species. since cloned cotton-top tamarin cell lines express three to six mhc class i molecules, this species must have at least three functional mhc class i loci. there was, however, no evidence of locus-specific s ... | 1991 | 1840570 |
| genetic variation of the glucocorticoid receptor from a steroid-resistant primate. | the neotropical cotton-top marmoset (saguinus oedipus) is a new world primate known to have markedly increased total and free plasma cortisol concentrations when compared with old world primates including man. the relative end-organ 'resistance' to glucocorticoids found in various new world primates has been attributed to a glucocorticoid receptor (gr) with diminished affinity for glucocorticoids. it has been demonstrated that the marmoset gr has approximately tenfold lower binding affinity for ... | 1991 | 1930628 |
| distribution of neuropeptide y in the prosencephalon of man and cotton-head tamarin (saguinus oedipus): colocalization with somatostatin in neurons of striatum and amygdala. | the presence, chromatographic properties and localization of neuropeptide y was demonstrated in postmortem human brain areas of neurologically and neuropsychiatrically normative controls using immunocytochemistry and high performance liquid chromatography combined with radioimmunoassay. npy-immunoreactivity was found in many regions of the prosencephalon. numerous perikarya and fibers were present in the neocortex, basal ganglia and limbic-hypothalamic areas. a moderate number of neurons and fib ... | 1990 | 1970228 |
| molecular cloning of cdna that encode mhc class i molecules from a new world primate (saguinus oedipus). natural selection acts at positions that may affect peptide presentation to t cells. | to investigate the evolutionary pressures that drive the generation of polymorphism in primate mhc class i molecules, three cdna that encode mhc class i alleles from a new world monkey, the cotton-top tamarin (saguinus oedipus), were cloned and sequenced. these tamarin mhc class i alleles contained amino acid substitutions not found in any of the previously sequenced human mhc class i alleles. moreover, the majority of these unique amino acid substitutions was located in the ag recognition site ... | 1990 | 2104912 |
| food-sharing in cotton-top tamarins (saguinus oedipus). | food-sharing behaviour was observed in 9 captive families of cotton-top tamarins (range 4-14 individuals per group), during meals of fresh fruit. food was transferred to infants by their parents and older sibs in response to begging, and was also offered to them without prior solicitation. older, mature, reproductively suppressed individuals shared more than young immature monkeys. infants in larger families received more food than those in smaller ones, though individuals in smaller families sh ... | 1990 | 2108914 |
| genetically distinct cell populations in naturally occurring bone marrow-chimeric primates express similar mhc class i gene products. | the cotton-top tamarin (saguinus oedipus) is a naturally occurring "a" + "b"----"a" bone marrow-chimeric species. these primates usually are born as dizygotic twins and, due to placental vascular anastomoses, develop sharing each others' bone marrow elements. strikingly, almost 50% of the pbl of a member of a twin pair are derived from the hematopoietic stem cells of its cotwin. to clarify the mechanisms underlying the maintenance of tolerance in these stable chimeras, mhc gene products have bee ... | 1990 | 2110210 |
| evolution of the mhc class i genes of a new world primate from ancestral homologues of human non-classical genes. | the products of the classical human major histocompatibility complex (mhc) class i genes (hla-a, -b, -c) are highly polymorphic molecules that bind peptides and present them to t lymphocytes. the non-polymorphic, non-classical mhc class i gene products (hla-e, -f, -g) are not restricting elements for the majority of t lymphocytes. the evolutionary relationship of the non-classical and classical mhc class i genes is unclear. here we present the cloning and sequencing of the mhc class i genes of a ... | 1990 | 2114550 |
| polymorphisms of the group-specific component (gc) in three species of tamarins (saguinus oedipus, s. labiatus, s. mystax). | 2006 | 2117093 | |
| cpg methylation of viral dna in ebv-associated tumours. | in ebv-immortalized lymphoblastoid cell lines (lcls) a small number of "latent" proteins are expressed. these are the ebv nuclear antigens, ebnas 1-6, and a latent membrane protein, lmp. we have investigated the expression of these proteins in a variety of ebv-associated tumours and cell lines. whereas transplant and b-cell lymphomas from cotton-top tamarins appear to express the full range of antigens found in lcls, we and others have found that in burkitt's lymphomas (bl) and a nasopharyngeal ... | 1990 | 2161800 |
| nursing does affect the duration of the post-partum to ovulation interval in cotton-top tamarins (saguinus oedipus). | reports on callitrichid monkeys have not revealed a significant effect of nursing on interbirth intervals or on post-partum to ovulation intervals. we examined 25 post-partum intervals in cotton-top tamarin females to determine whether nursing infants would affect the length of the post-partum to ovulation interval. urinary lh/cg and oestrone conjugates were measured in urine samples collected in the 6 weeks after birth. the post-partum to ovulation interval is the number of days between parturi ... | 1990 | 2174459 |
| expression of immune sensitization to epithelial cell-associated components in the cotton-top tamarin: a model of chronic ulcerative colitis. | chronic colitis is present in up to 50% of adult cotton-top tamarins, but the etiology is unknown. to explore one putative immunopathogenic pathway for the chronic colitis, we determined whether immune sensitization to macromolecules associated with mucosal epithelium of intestine (designated ecac) had occurred in this primate species. specifically, we sought to define (a) whether antigenic determinants associated with ecac are present on tamarin gut epithelium in vivo; (b) if immunoglobulin, ca ... | 1989 | 2477296 |
| analysis of t lymphocyte subsets in tamarins with colitis and colon cancer. | the cotton-top tamarin, saguinus oedipus, serves as an animal model for the study of human colon cancer. this new world monkey has a high incidence of colitis and colon cancer that develops spontaneously. evidence suggests that these diseases may be the result of a virally induced immunodeficiency. we have shown that t4+/t8+ cell ratios are significantly altered in tamarins with acute colitis and colon cancers. the t4+/t8+ ratios were 1.50 +/- 0.09, 0.70 +/- 0.05, and 0.48 +/- 0.05 for negative ... | 1989 | 2493193 |
| focal ulcerative ileocolitis with terminal thrombocytopenic purpura in juvenile cotton top tamarins (saguinus oedipus). | a newly recognized syndrome characterized by an acute focal ulcerative ileocolitis, anemia and thrombocytopenic purpura in five juvenile cotton-top tamarins is described. the presentation and morphology of this syndrome is distinct from any other reported gastrointestinal disease reported in tamarins. traditional etiologies such as viruses, ingested toxins, campylobacter, salmonella and yersinia and clostridium difficile are not considered likely etiologic agents. nontraditional etiologies such ... | 1989 | 2496272 |
| inoculation of new world primates with the human immunodeficiency virus. | the susceptibility of common marmosets and cotton-top tamarins to infection by hiv-2 in vivo was tested. one year and 19 months, respectively, post-inoculation, sera taken from three of four animals from each species are reactive for hiv-2 antibodies and hiv-specific nucleotide sequences were demonstrated in short-term cultures of pbl from two cotton-top tamarins. the animals remain in good health. | 1989 | 2503618 |
| gene mapping of an epstein-barr virus isolate obtained from a nasopharyngeal carcinoma. | gene mapping of an epstein-barr virus (ebv) isolate derived from a nasopharyngeal carcinoma (npc), designated npc-ebv, has been performed. this isolate was rescued from an npc epithelial hybrid cell line (npc-kt), and used to transform cotton-top tamarin lymphocytes which, along with the epithelial npc-kt cells, were used in the mapping studies. using the bamhi and ecori restriction enzymes, we found that the npc-ebv isolate did not contain the deletions observed in the genomes of the prototype ... | 1989 | 2542179 |
| the transforming prototype of epstein-barr virus (b95-8) is also a lytic virus. | the b95-8 isolate of the epstein-barr virus (ebv) has been described as a non-lytic transforming virus. we have performed experiments in order to determine if the b95-8 ebv is capable of super-infecting and replicating in ebv-genome-positive non-producer lymphoblastoid cells. using concentrates of b95-8 ebv, prepared from 6 different b95-8 cell lines treated with 12-o-tetradecanoylphorbol-13-acetate (tpa), we demonstrated that virus concentrates could transform human or cotton-top tamarin b-lymp ... | 1989 | 2545637 |
| validation of a first-generation epstein-barr virus vaccine preparation suitable for human use. | the efficacy of a new vaccine preparation against epstein-barr (eb) virus was investigated in cotton-top tamarins. the vaccine consists of fast protein liquid chromatography-purified eb virus membrane antigen glycoprotein of 340 kd (ma gp340) mixed with a synthetic muramyl dipeptide adjuvant emulsified in squalane containing a pluronic polymer; it is suitable for both scaled-up batch production and eventual administration to man. vaccinated tamarins rapidly developed elisa detectable high titre ... | 1989 | 2555448 |
| presence of antibody to human herpesvirus 6 in monkeys. | a serological survey of monkeys was conducted to determine the prevalence of antibody to human herpesvirus 6 (hhv-6). two-hundred and fifteen sera from 10 species of monkeys were examined by an immunofluorescent antibody (if) assay. the antibody was found in monkeys from eight of the 10 species examined, but was not detected in silvered lutongs or cotton-top tamarins. the prevalence of antibody was highest in squirrel monkeys. sera with high antibody titres were examined further by western blot ... | 1989 | 2558155 |
| growth of b95-8 cells and expression of epstein-barr virus lytic phase in serum-free medium. | epstein-barr virus (ebv)-transformed tamarin (saguinus oedipus) cells (b95-8) were selected for growth in medium with reduced serum and then transferred to serum-free medium which consisted of rpmi 1640 supplemented with insulin, transferrin, and selenium. serum-free cells in continuous passage for 1 year had a morphology, growth rate, and culture density which approached those of b95-8 cells grown with serum. the cells expressed virus-induced antigens, including the ebv-associated dna polymeras ... | 1987 | 2824833 |
| intestinal carcinomas in two tamarins (saguinus fuscicollis, saguinus oedipus) of the german primate centre. | two colonic mucoid adenocarcinomas in tamarins from the german primate centre are reported. a mucinous mucoid adenocarcinoma occurred in the ascending and the transversal colon of a saguinus oedipus male more than 8 years old, with metastases in the regional lymph nodes and the pancreas. the tumour corresponded to colon cancer in cotton-topped tamarins of other colonies. the second tumour, a well differentiated tubular mucoid adenocarcinoma, developed at the ileocaecal valve of a 14 1/2 year old ... | 1988 | 2839732 |
| maintenance of growth transformation with epstein-barr virus is mediated by secretion of autocrine growth factors in two serum-free b-cell lines. | the characteristics of two tamarin (saguinus oedipus) b-cell lines (sfbit and sfbt) growth-transformed by epstein-barr virus (ebv) that proliferate continuously in serum-free medium are described. sfbit was established by selecting cells for growth in rpmi 1640 supplemented with insulin, transferrin, and selenium (j. e. shaw, r. g. petit, and k. leung, j. virol. 61:4033-4037, 1987). sfbt, a subline of sfbit cells reported here for the first time, required transferrin as the only protein suppleme ... | 1988 | 2841494 |
| demonstration in vitro of cell mediated immunity to epstein-barr virus in cotton-top tamarins. | in the course of developing an effective epstein-barr (eb) virus vaccine, the immune responses in cotton-top tamarins to a tumourigenic dose of eb virus were studied. cell mediated responses were measured using a tissue culture 'growth inhibition' assay where peripheral blood lymphocytes were tested for their ability to inhibit the outgrowth of autologous eb virus transformed lymphoblastoid cells. this system has previously been recognized as a very sensitive assay for detecting cell-mediated re ... | 1988 | 2846217 |
| characterization of spontaneous colitis in cotton-top tamarins (saguinus oedipus) and its response to sulfasalazine. | chronic colitis in the cotton-top tamarin (ctt) has been characterized by obtaining distal colonic biopsy specimens, hematocrits, serum albumins, and stools for bacteriologic and parasitic examination in nondebilitated living ctts. the species specificity of the histologic features of colitis observed in the ctt was assessed by obtaining distal colonic biopsy specimens from 10 animals of other primate species for histologic examination. histologic evidence of active colitis was found in 50% of a ... | 1985 | 2856876 |
| the florey lecture, 1986. vaccine prevention of virus-induced human cancers. | carcinogenic viruses have been discovered in numerous animal species over the last 80 years but their role in human cancer has only recently become an important issue. with eb virus involved with endemic burkitt's lymphoma and undifferentiated nasopharyngeal carcinoma, hepatitis b virus with primary liver cancer, papilloma viruses with carcinoma of the cervix, and t-cell leukaemia virus with adult t leukaemia, 20-25% of all human cancer appears to have a virus component in its causation. by anal ... | 1987 | 2884667 |
| a primate species with limited major histocompatibility complex class i polymorphism. | extensive polymorphism at the major histo-compatibility complex (mhc) is thought to confer immune protection on populations. a new world primate, the cotton-top tamarin (saguinus oedipus), has a high prevalence of ulcerative colitis and adenocarcinoma of the colon and dies after infection with several human viruses. lymphocytes from all animals tested expressed on common mhc class i allelic product. another mhc class i allelic product was expressed by 39 of 41 tested animals. four other allelic ... | 1988 | 2902637 |
| individual tumors of multifocal eb virus-induced malignant lymphomas in tamarins arise from different b-cell clones. | cotton-top tamarins were inoculated with sufficient epstein-barr virus to induce multiple tumors in each animal within 14 to 21 days. the tumors consisted of large-cell lymphomas that contained multiple copies of the epstein-barr virus genome and generated epstein-barr virus-carrying cell lines showing no detectable consistent chromosomal abnormality. hybridization of tumor dna with immunoglobulin gene probes revealed that each lymphoma was oligo- or monoclonal in origin and that individual tumo ... | 1985 | 2986287 |
| in vitro growth characteristics of simian t-lymphotropic virus type iii. | the type c retrovirus simian t-lymphotropic virus type iii (stlv-iii) has been isolated recently from immunodeficient macaque monkeys at the new england regional primate research center. the present studies were done to define the in vitro growth characteristics of this agent. stlv-iii replicates efficiently in interleukin 2-dependent t-cell cultures of macaque peripheral blood lymphocytes (pbl), less efficiently in such cultures of human and gibbon pbl, and inefficiently in baboon pbl. no repli ... | 1985 | 2996002 |
| protection of cottontop tamarins against epstein-barr virus-induced malignant lymphoma by a prototype subunit vaccine. | epstein-barr (eb) virus is one of the five herpesviruses of man. strong links between this agent and the chain of events causing two human cancers, endemic burkitt's lymphoma and undifferentiated nasopharyngeal carcinoma, have long been evident (reviewed in ref. 1). because of this, and because of the very high incidence of nasopharyngeal carcinoma in certain large populations, it was suggested in 1976 that a vaccine should be developed against eb virus to prevent infection and thereby reduce tu ... | 1985 | 2999604 |
| nononcogenic deletion mutants of herpesvirus saimiri are defective for in vitro immortalization. | herpesvirus saimiri l-dna sequences between 0.0 and 4.0 map units (4.5 kilobase pairs) are required for oncogenicity; these sequences are not required for replication of the virus. to investigate the basis for the lack of oncogenicity of mutants with deletions in this region and to study the function of this region, we developed a reliable system for in vitro immortalization by herpesvirus saimiri. in contrast to peripheral blood lymphocytes from cotton-top tamarins (saguinus oedipus) and owl mo ... | 1986 | 3003401 |
| glucocorticoid receptors in epstein-barr virus-transformed lymphocytes from patients with glucocorticoid resistance and a glucocorticoid-resistant new world primate species. | members of a previously reported family with glucocorticoid resistance and several new world primates have high plasma cortisol concentrations without any signs of glucocorticoid excess. the glucocorticoid receptor in circulating leukocytes and cultured skin fibroblasts from these patients and the animals is characterized by a decreased affinity for dexamethasone. on the other hand, the cell content of receptor is similar to that of corresponding tissues of normal humans. detailed biochemical-bi ... | 1986 | 3009520 |
| congenital anomalies in two neonatal tamarins (saguinus oedipus and saguinus fuscicollis). | congenital anomalies were seen at necropsy of two neonatal tamarins. the defects included achondroplastic-like dwarfism, polydactyly and syndactyly in a saguinus oedipus, and scoliosis and uterus didelphys in a s. fuscicollis. both infants were the offspring of incestuous matings between twin siblings. | 1986 | 3027346 |
| specific immune serum to the epstein-barr virus dna polymerase. | epstein-barr virus (ebv) dna polymerase was released from phorbol ester-treated tamarin (saguinus oedipus) cells (b95-8) and prepared for use as an antigen by sequential column chromatography with deae-sephadex a-25, deae-cellulose, phosphocellulose, and single-stranded dna cellulose. proteins from single-stranded dna cellulose with dna polymerase activity in 100 mm ammonium sulfate were mixed with complete freund adjuvant and injected intradermally into rats and rabbits. immune sera that were s ... | 1987 | 3041054 |
| technique for hand-rearing and reintroducing rejected cotton-top tamarin infants. | during a one year period, seven rejected cotton-top tamarin infants were hand-reared. a hand-rearing program was developed which included the use of heated surrogates, a non-human primate infant formula, special nipples, and a systematic reintroduction into a family group. this regimen was quite successful. the hand-rearing process yielded a success rate of 75.0%, while the reintroduction process had a success rate of 80.0% for reintroduction into a family group and 100.0% survival rate. | 1986 | 3088320 |
| high motivation toward food increases food-sharing in cotton-top tamarins. | in order to explore whether or not adult motivation influences transfer of food to infants in cotton-top tamarins (saguinus oedipus oedipus), 2 experiments were carried out with 3 large captive family groups. examination of (a) natural changes in food motivation during feeding, and (b) elevated motivation toward food by giving highly preferred items, showed that the adult monkeys shared food more when their own level of motivation was high. this suggests that food-transfer is not merely a conseq ... | 1986 | 3093299 |
| adenocarcinoma of the large bowel and colitis in captive cotton-top tamarins saguinus o. oedipus. | the gross and microscopic appearance of large bowel adenocarcinoma in two young adult, captive-born cotton-top tamarins is described. a retrospective examination of sections of colons from other animals that had died in the colony revealed a high incidence of chronic colitis. the adenocarcinomas, which resembled those reported from colonies of this species in the u.s.a., are thought to be the first seen in great britain. | 1986 | 3093542 |
| glycoconjugates in the colons of new world monkeys with spontaneous colitis. association between inflammation and neoplasia. | a spontaneously occurring experimental model of chronic colitis has been described in three closely related species of new world monkeys. one species, saguinus oedipus oedipus, has the additional feature of developing adenocarcinoma of the colon in this setting. pathological and lectin histochemistry studies were undertaken in 50 such colonic specimens to determine if pathological or histochemical features were associated with the concomitant development of cancer. chronic inflammation was found ... | 1987 | 3102306 |
| the endocrinology of puberty and reproductive functioning in female cotton-top tamarins (saguinus oedipus) under varying social conditions. | sexual maturation and fertility were assessed in fourteen cotton-top tamarin (saguinus oedipus) females under various social conditions. six tamarin females (20-28 mo of age) showed a suppression of fertility while living with their families. hormonal profiles demonstrated low, acyclic levels of urinary luteinizing hormone (lh) and estrone-conjugates (e1c). a rapid onset of ovarian and pituitary cyclicity occurred when four of the six females were removed from their families and paired with an u ... | 1987 | 3118981 |
| chronic colitis in common marmosets (callithrix jacchus) and cotton-top tamarins (saquinus oedipus). | 2011 | 3122405 | |
| characterization of colonic cellular glycoconjugates in colitis and cancer-prone tamarins versus colitis and cancer-resistant primates. | differences in colonic secretory glycoconjugates (ie, mucin) between normal and ulcerative colitis-prone patients have been noted. similar differences may occur in a corresponding primate model, the cotton-top tamarin (ctt), saguinus oedipus, a new world monkey which suffers from spontaneous chronic colitis and colon cancer. lectin reagents were used to characterize and compare colonic cell surface, cytoplasmic, and secretory glycoconjugates of 9 clinically healthy cotton-top tamarins, 7 colitis ... | 1988 | 3132857 |
| differences in cellular glycoconjugates of quiescent, inflamed, and neoplastic colonic epithelium in colitis and cancer-prone tamarins. | in the preceding paper the authors demonstrated that the lectin staining patterns of normal colonic epithelium obtained from colitis and carcinoma-prone cotton top tamarins (ctts), saguinus oedipus, a new world primate, differs from colitis- and carcinoma-resistant primate species. in this study they determined the usefulness of cytochemical features in inflamed epithelium as indicators for malignant change. they compared the lectin staining pattern in inflamed mucosa and adjacent mucosa with co ... | 1988 | 3132858 |
| effect of various biological factors on spontaneous marmoset and tamarin colitis. a retrospective histopathologic study. | histological sections of colons from 69 tamarins (46 saguinus oedipus and 23 saguinus fuscicollis illigeri) and 27 marmosets (callithrix jacchus) that died between 1979 and 1984 were examined for colitis. evaluated biological factors were species, age at death, source of animals, manner of death, presence of colon cancer, and time after importation. most normal colons were found in young animals (dead at less than 1 years of age). nearly all (approximately 96%) animals had colitis; 70-80% of mos ... | 1988 | 3134175 |
| colon cancer cells in peripheral blood of cancerous tamarins. | diagnosing colon cancer in its early stages would lower the mortality rate. the cotton-top tamarin, saguinus oedipus, serves as a model for the study of human colon cancer. this new world monkey has a high incidence of colitis and colon cancer. the mouse anti-human monoclonal antibody br55.2, with specificity for human colon adenocarcinoma, was biotinylated. peripheral blood mononuclear cells (pbmc) from animals with colon cancer were fluorescently stained with the biotinylated br55.2. these res ... | 1988 | 3135964 |
| color discrimination by the cotton-top tamarin (saguinus oedipus oedipus) and its relation to fruit coloration. | old world monkeys and apes have been reported to differ from new world monkeys in their abilities to discriminate colors across the visible spectrum. old world monkeys and apes (macaca, pan, pongo) discriminate colors quite accurately, while some new world monkeys studied (saimiri, cebus) have shown lower sensitivity to and poorer discrimination of long wavelength light. this study examined the color discrimination ability of another new world primate, the cotton-top tamarin, saguinus oedipus oe ... | 1987 | 3136059 |
| maintenance of cotton-top tamarins fed an experimental pelleted diet versus a highly diverse sweetened diet. | the future study of colon disease in captive callitrichid colonies may require manipulation of diets. the limited knowledge of the nutritional requirements for these species and the varied diets and supplementations fed to these animals in various colonies suggest the importance of testing the palatability and acceptability of diets for these primates. individually housed cotton-top tamarins (saguinus oedipus) were given either the regular oak ridge associated universities (orau) diet (monkey ch ... | 1988 | 3143029 |
| kin preference in marmosets and tamarins: saguinus oedipus and callithrix jacchus (callitrichidae, primates). | field studies on callitrichid primates have suggested that some species may exhibit a communal breeding system in which two or more males mate with a single female and cooperatively participate in infant rearing. however, high levels of aggression have been observed between males under both laboratory and field conditions. in avian models for communal breeding, cooperating males are often closely related. in a laboratory test of a hypothesis of the amelioration of aggression based on kinship, fo ... | 2011 | 3147598 |
| a naturally occurring bone-marrow-chimeric primate. i. integrity of its immune system. | the new world primate species saguinus oedipus, the cotton-top tamarin, has a high incidence of spontaneously occurring adenocarcinoma of the colon and develops a fatal lymphoproliferative syndrome following infection with various herpes viruses. some investigators have linked such disease susceptibilities to abnormalities in the immune function of the cotton-top tamarin that may result from the natural bone marrow chimerism that occurs in this species. the present studies were initiated to esta ... | 1985 | 3156438 |
| the isolation and characterization of the human helper inducer t cell subset. | monoclonal antibody anti-4b4 was produced by fusing ns1 myeloma with spleen cells of a mouse immunized with saguinus oedipus lymphocyte. this anti-4b4 antibody defines a 135-kd cell surface protein that is widely distributed throughout the hematopoietic system. more importantly, anti-4b4 is reactive with functionally unique human t cell subsets. anti-4b4 antibody was reactive with approximately 41% of unfractionated t cells, 41% of t4+ inducer cells, and approximately 43% of t8+ cytotoxic/suppre ... | 1985 | 3157750 |
| colonic mucin composition in primates. selective alterations associated with spontaneous colitis in the cotton-top tamarin. | heterogeneity of colonic mucin glycoprotein was examined in rectal mucosal biopsy specimens from a variety of primate species (saguinus oedipus, n = 18; macaca mulatta, n = 2; macaca fascicularis, n = 2; aotus trivirgatus, n = 2; saimiri sciureus, n = 2; and callithrix jacchus, n = 2). after initial separation of radiolabeled mucin and nonmucin glycoproteins solubilized from mucosal biopsy specimens, at least five labeled mucin components were found in monkey rectal mucosa in contrast to the six ... | 1985 | 3917260 |
| is cancer of the colon familial in cotton-top tamarins? | ten cases of spontaneous adenocarcinoma of the colon were observed in first-generation saguinus oedipus oedipus born and raised under defined colony conditions. in this series of 10 cases, 3 animals had a wild parent (caught and imported) that also died of cancer of the colon and 4 of the remaining 7 were two unrelated sets of siblings (one a set of fraternal twins). this somewhat unexpected familial association or clustering of these malignancies suggests the possibility of a significant heredi ... | 1985 | 3917368 |
| renal papillary adenoma in a cotton-topped tamarin (saguinus oedipus). | the second case of a renal tumour in a tamarin is described. the incidentally discovered unilateral tumour developed in an adult female cotton-topped tamarin. it did not cause clinical symptoms and was classified as a papillary adenoma based on its morphological characteristics. | 1985 | 3923265 |
| a breeding colony of cotton-top tamarins (saguinus oedipus). | a breeding colony of cotton-top tamarins is described where 91% of the breeding females are from the first and second laboratory-born generations, and whose infants have a one year survival rate of 62%. mortality is greatest in the first week of life, and mortality rate is greater for a female's first litter than for subsequent litters. females without early experience in caring for other infants have a higher infant mortality rate than females with such experience. no seasonal birth patterns ha ... | 1985 | 3932776 |
| natural history and pathology of colon cancer in saguinus oedipus oedipus. | 2013 | 3933926 | |
| histology of colon cancer in saguinus oedipus oedipus. | diagnosis of colon cancer in tamarins often requires histologic (microscopic) inspection of the entire colon before minute primary sites can be located in the flat colonic mucosa. in other cases the cancer is easily recognized grossly because infiltration produces local desmoplastic reactions. the cancer does not have a preceding benign polypoid stage. the carcinoma is most typically poorly differentiated. the pas stain, however, demonstrates that some of the malignant cells always produce mucin ... | 1985 | 3933929 |
| comments on comparative pathology of colonic neoplasia in cotton-top marmoset (saguinus oedipus oedipus). | 1985 | 3933930 | |
| monoclonal antibody-defined antigens detected in colonic tissues of cotton-top tamarin, saguinus oedipus oedipus. | 1985 | 3933932 | |
| histology of colitis: saguinus oedipus oedipus and other marmosets. | 1985 | 3933936 | |
| evolution and natural history of colonic disease in cotton-top tamarins (saguinus oedipus). | 1985 | 3933937 | |
| nonviral infectious agents and marmoset (saguinus oedipus) colitis. | 1985 | 3933938 | |
| rearing a second generation of cotton-top tamarins (saguinus oedipus oedipus) in captivity. | the average age at first parturition in captive-born female cotton-top tamarins was 31 months. only 18% of full-term young born were successfully reared by primiparous females, but success increased with parity and 71% of babies born at 4th and 5th pregnancies were raised. 15% of litters were single births, 61% were twins and 24% were triplets. there was a seasonal distribution of births, with a clear peak in the spring months. the average interbirth interval was 294 days. | 1985 | 3934462 |
| monkey dander asthma. | we recently cared for two patients who experienced acute asthma with exposure to dander of the cotton top tamarin, a species of new world monkey. both patients had serologic evidence for an ige antibody to monkey dander as determined by rast and a positive immediate skin test response to an extract prepared from monkey dander. furthermore, by rast we were able to determine that cotton top tamarin urine and newborn cotton top tamarin dander had antigens that reacted with ige in the serum of the a ... | 1985 | 3968337 |
| diet induced jejunal lipodystrophy in the cotton top marmoset (saguinus oedipus). | 1971 | 4108179 |