Publications

[intratypical antigenic differentiation of poliovirus strains circulating in mali by means of cross-adsorbed sera].	the intratypic antigenic differentiation of poliovirus strains isolated from sick or healthy children in mali in 1975-1976 was performed. the method is based on the use of cross-adsorbed sera in the neutralization tests in which the virus is titrated by the plaque procedure or by the cytopathic effect. all the examined strains of serologic types i, ii, and iii were distinguished by the antigenic structure from the vaccine strains and were classified as "wild". quantitative differences in the ant ...	1978	86237
the use of trypan blue for counterstaining in the sepharose bead immunofluorescence test. the application of the test for the demonstration of primate retrovirus-specific antibodies and antigens.	the sepharose bead immunoflurorescence test was performed by counterstaining the beads with trypan blue. this results in a red staining of negative beads which allows an easy distinction from positive green-fluorescent beads. sepharose beads conjugated with viral proteins or antiviral antibodies were used to demonstrate mason-pfizer monkey virus (mpmw)- and simian sarcoma virus (ssv) - specific antigens or antibodies. the test shows a high sensitivity and specificity and needs a small amount of ...	1978	86253
tissue cea in premalignant epithelial lesions and epidermoid carcinoma of the uterine cervix: prognostic significance.	carcinoembryonic antigen (cea) was studied by the indirect triple-bridge immunoperoxidase method in formalin-fixed paraffin-embedded tissue specimens from 191 patients with premalignant epithelial lesions or epidermoid carcinoma of the uterine cervix treated 12 years ago. the frequency of tissue cea positivity was found to increase with advancing clinical disease in the following manner: mild dysplasia, 25%; severe dysplasia, 37%; carcinoma in situ, 60%; invasive carcinoma stage i, 60%; stage ii ...	2000	86522
benign prostatic hypertrophy: when should you consider prostatectomy for your patient?	watching the way a patient voids is the easiest way to determine the presence of prostatic obstruction. uroflowmetry can objectively measure the amount of obstruction. clinical evaluation of prostatism should include an intravenous urogram, serum creatinine determination, urinalysis, urine culture, and cystoscopy. suspicious areas of induration in the prostate should be biopsied. surgery is not required for most men with prostatic hypertrophy. indications for prostatectomy are severe symptoms of ...	2000	87358
neutral lipid and sphingolipid composition of the brain of a patient with membranous lipodystrophy.	lipids were extracted from brains of a patient with membranous lipodystrophy (ml) and three normal patients and the neutral lipid and sphingolipid constituents were investigated. the storage of a large amount of free fatty acid was observed in the ml brain, but no cholesterol ester was found. total lipid, cholesterol and cerebroside contents were slightly decreased in the white matter of the ml brain. the composition of free and sphingolipid fatty acids did not differ between ml and normal brain ...	2000	87500
new consultant contract.		2001	87861
fatal leishmaniasis in renal-transport patient.		1999	88649
[nuclear surface of buccal cells as a function of the nature of the stain. measurements with an image analyzing computer].	measure of nuclear areas was performed on buccal smears by the quantimet 720 image analysing computer. five different staining procedures were used and we consider that toluidin blue at ph 4 is the best for a fine quantitative caryometry.	2001	88973
inheritance of tolerance susceptibility to human gamma-globulin in congenic mice.	the genetic control of susceptibility to tolerance induction with human gamma-globulin (hgg) was studied by using h-2 congenic mice. strains tested that were congenic with c57bl/10sn were completely tolerized by 1.0 mg deaggregated hgg. in contrast a/sn mice showed full tolerance whereas a.sw mice were only intermediately tolerant. it was further shown that (b10 x sjl)f1 mice could be rendered tolerant but (b10.s x sjl)f1 mice could not. these data indicate a role for h-2 linked genes in control ...	1979	89162
acid fast staining of oxidized neuromelanin and lipofuscin in the human brain.	acid fast staining of the bleached residuum of substantia nigra neuromelanin and of oxidized inferior olive lipofuscin was demonstrated in paraffin and frozen sections stained with the acetic acid, carbol fuchsin method of barbeito-lopez and the aldehyde fuchsin method of gomori. acid fast staining occurred when sections were exposed to a prestain oxidation with potassium permanganate in conjunction with a poststain differentiation with dilute hydrochloric acid. the acid fast staining with aceti ...	1979	89189
john frederick paterson.		1999	89445
vitiligo patterns simulating autoimmune and rheumatic diseases.	several variants of generalised vitiligo can be recognised by their cutaneous distribution. in some, certain anatomical regions--e.g., hands--are predominantly affected while the cutaneous depigmentation in other variants shows a similar anatomical distribution to that of the internal structures affected in some of the autoimmune and rheumatic diseases. five patients have been seen, and three described by others, with vitiligo affecting skin of eyelids and lower front of neck, reminiscent of the ...	1999	89452
jack tizard.		1999	89494
independent learning packages (audio tape/pamphlet) for a course in cell excitation: evidence that they can be at least as effective as conventional lectures.	three tape/pamphlet independent learning packages have been constructed to serve the same learning objectives as three conventional lectures on the physiology of the nerve axon. the learning efficacy of each package was compared with that of its companion lecture with the co-operation of fifty first-year medical students in a controlled experiment. the packages were at least as effective as the lectures in generating both short- and long-term attainment of their intrinsic learning objectives. th ...	2000	89619
histamine-releasing effect of a corticotrophin derivative. ii. mechanism of action of histamine release by c 44 680-ba, compared with that of cpd. 48/80, dextran and triton.	the mechanism of the histamine-liberating action of the synthetic polypeptide c 44 680-ba, an alkyl-prolyl derivative of beta 1-19 corticotrophin, was investigated and compared with those of compound 48/80, dextran, melittin and triton x-100. it was found that the release of histamine from rat peritoneal cells induced by the polypeptide is dependent on temperature, ph, calcium ions and energy-providing processes. in regard to these criteria, the mode of action of this histamine liberator resembl ...	1979	89804
distribution of myosin isoenzymes among skeletal muscle fiber types.	using an immunocytochemical approach, we have demonstrated a preferential distribution of myosin isoenzymes with respect to the pattern of fiber types in skeletal muscles of the rat. in an earlier study, we had shown that fluorescein-labeled antibody against "white" myosin from the chicken pectoralis stained all the white, intermediate and about half the red fibers of the rat diaphragm, a fast-twitch muscle (gauthier and lowey, 1977). we have now extended this study to include antibodies prepare ...	1979	90047
the use of avidin-biotin interaction in immunoenzymatic techniques.	biotin was covalently attached to antibodies, antigens and enzymes, and the effects of this labeling on the antigen and antibody binding capacity and on enzymatic activity were tested. based on avidin-biotin interaction, the labeled proteins were used in quantitative enzyme-immunoassay and enzyme-immunohistochemical staining procedures. two procedures were developed. in the first procedure, named the bridged avidin-biotin (brab) technique four steps were used sequentially in order to quantify or ...	1979	90074
fetal heart-rate monitoring.		2001	90290
organizing library audiovisual services to support continuing education.		2001	90336
the expression of a human b-lymphocyte antigen and surface membrane immunoglobulin by lymphoid cells from patients with lymphocytic lymphoma, multiple myeloma and benign monoclonal gammapathy.		1979	90449
the intra-nucleolar localization of amplified rdna in xenopus laevis oocytes.	a fluorescent feulgen-stain was adapted in order to demonstrate dna-containing structures inside the amplified nucleoli of xenopus laevis. at all stages of oogenesis this method reveals granules or complex structures of dna in each nucleolus. the micronucleoli which do not stain with this method and which do not reveal an internal structure in low molarity saline, unlike real nucleoli are considered as nucleolus-like bodies. the dna-containing structures in the nucleoli can be composed of one or ...	1979	90588
the indirect rat mast cell degranulation test reconsidered.	the indirect rat mast cell degranulation test for the detection of human reaginic antibodies was reinvestigated. when the mast cells were incubated with human reaginic serum at concentrations exceeding approximately 3%, a massive, non-specific histamine release occurred, irrespective of the presence or absence of allergen. at tolerated serum concentrations (below 3%), the allergen concentration did not influence the release process. we conclude that the indirect rat mast cell test is not applica ...	1979	90655
antigens in penicillin allergy. iv. induction of ige antibody response in mice after daily treatment with contaminated but not with pure penicillin.		1979	90657
characterization of a type-c virus produced by co-cultures of human leukemic bone-marrow and fetal canine thymus cells.	the putative human helper virus ska-21/a204v, isolated by nooter et al. in 1977 from human leukemic bone-marrow cells following co-culture with normal fetal canine thymus cells, cf2th, has been characterized with respect to its major viral core protein, reverse transcriptase, and nucleic acid sequences. the results of these analyses show that this virus is not distinguishable from the woolly monkey type-c virus, ssav-1, by the techniques employed.	1979	90662
use of immunoadsorbents for the study of antibody binding to sperm whale myoglobin and its synthetic antigenic sites.	conditions for preparing immunoadsorbents of sperm-whale myoglobin and its five synthetic antigenic sites and for desorption of radiolabeled antibodies from the immunoadsorbents were studied. in immunoadsorbent titration studies, the sum of the amounts of antibodies bound in the plateau (maximum binding) by the adsorbents of the five sites accounted quantitatively for the entire (100%) antibody response to sperm-whale myoglobin.	1999	91647
trace polypeptides in cellular extracts and human body fluids detected by two-dimensional electrophoresis and a highly sensitive silver stain.	development of a highly sensitive silver stain permits the characterization of trace cellular and body fluid proteins separated by the two-dimensional electrophoresis technique of o'farrell. many of the proteins detected by the silver stain in urine, spinal fluid, amniotic fluid, and cells were undetected with the widely used coomassie blue stain. trace polypeptides observed in escherichia coli cell lysates with this silver stain could be detected previously only by growth in radioactive precurs ...	1979	92027
epithelioid sarcoma: ultrastructural observation of lymphoid cell-induced lysis of tumor cells.	epithelioid sarcoma of the palm of 7 months' duration was observed in a 30-year-old man. six months after wide surgical excision there was no evidence of recurrence or metastasis. by light microscopic examination the tumor showed typical nodular arrangement of malignant cells, with necrosis of these cells in the centers of the nodules. patchy lymphocytic infiltrates were observed at the peripheries of the nodules and also extended in places between the tumor cells. other types of inflammatory ce ...	1979	92147
membrane-bound mitochondrial dna: isolation, transcription and protein composition.	mitochondrial membrane-bound dna complex from bovine heart mitochondria lysed in the presence of triton x-100 was isolated by differential centrifugation. the yield of "nucleoid" is about 30 microgram protein/mg mitochondrial protein. it contains about 3-5 microgram dna/mg protein and varying amounts of rna. the heart mitochondrial nucleoid actively synthesizes rna. the nucleoid fraction contains about sixteen different proteins as evidenced by urea-sds gel electrophoresis and about twenty-one p ...	1979	92288
oral rehydration of neonates with dehydrating diarrhoeas.	thirty-nine of forty neonates with mean dehydration equivalent to 6.7% of body-weight were orally rehydrated with a glucose/electrolyte solution. only one patient required any intravenous fluids for rehydration. hypernatraemia and acidosis present at admission were corrected within a few hours without complications. it seems that oral rehydration, is suitable for neonates as well as for children and adults.	2001	92621
the effect of dose loading and of double labelling with 57co and 125i on the tissue distribution in animals.	dose loading effects upon the performance of 57co-bleomycin as a tumor localizing agent have been investigated in rhabdomyosarcoma bearing wag/ry rats. the addition of non-radioactively labelled co-bleomycin increased the relative uptake of 57co-bleomycin in rapid growing tumors, but the addition of non-chelated bleomycin had no influence at all. in our experimental system, iodinated bleomycin generally labelled by reaction with icl, was found to be an unsatisfactory tumor localizing agent. in o ...	1979	93048
staining of acid mucopolysaccharides appearing on and in various cell types by dapi.	it could be shown that dapi, a newer fluorochrome (4',6-diamidino-2-phenylindole), is able to stain various types of acid mucopolysaccharides, e.g. heparin and agar mucopolysaccharides. due to their content of heparin, mast cells and basophil cells could be stained rapidly. other cells e.g. mononuclear phagocytes and malignant epithelial cells, could be loaded with these acid mucopolysaccharides and subsequently stained by dapi.	1999	93685
enhancement of the action of bleomycin using liposome with ehrlich's ascites carcinoma in mice.		2000	94590
brl10833 in inhibiting exercise-induced bronchoconstriction in asthmatic children.	a double-blind controlled exercise challenge study has been performed in 16 asthmatic chlidren to show the effectiveness of brl10833 in inhibiting exercise-induced bronchoconstriction. the children attended the respiratory laboratory on four occasions within the space of two weeks; on each occassion a routine 6-min exercise test was performed. at the first visit no drugs were given before the exercise test and all the children demonstrated abnormal exercise-induced bronchoconstriction as measure ...	2001	100129
immediate results of weekly fractionation in external radiotherapy.		2000	101487
[studies on moraxella. i. a new selective medium for moraxella sp. (author's transl)].		1977	101603
[volatile fatty acids in gastrointestinal diseases in young infants].		1978	101958
purification and some properties of porcine brain mitochondrial monoamine oxidase b.		1978	103556
[isolation of treponemas from the colon of pigs with clinical dysentery].	optimal culture conditions in artificial nutritive media were determined for a defined avirulent strain of treponema hyodysenteriae and for four field strains of treponemas in pigs with clinical dysentery. the treponemas were isolated with the use of milliporous filters with pores of 0.3 micrometer in diameter, which were located on the surface of blood agar. no significant difference in the influence of equine, bovine or sheep blood on the growth of treponemas was determined. the commercial amo ...	1979	105448
[c-peptide, igg-insulin antibodies, island cell antibodies and immune response genes in diabetes mellitus].		1998	105488
total nose reconstruction: a single stage method.		1998	105856
affinity chromatography of endoglucanase of trichoderma viride by concanavalin a-agarose.	endoglucanase (c kappa cellulase) and cellobiase are often cross-contaminated in separation procedures by ion-exchange chromatography such as deae-cellulose. by using concanavalian a (con a)-agarose chromatography, c kappa cellulase and cellobiase from trichoderma virde can be separated. c kappa cellulase showed affinity toward con a. indicating a glycoprotein containing alpha-d-mannopyransyl and alpha-d-glucopyranosyl end groups or internal 2-o-d-mannopyranosyl residues in sugar moieties. this ...	1979	106904
the diagnosis of genitourinary neoplasms.		2002	123911
[homologous transplants in the middle ear (author's transl)].	the original concept of tympanoplasty included besides the closure of the middle ear, the removal of pathological middle ear components leaving intact the functional and healthy components. the special conditions that prevail in the middle ear (aeration, absence of intrinsic trauma) allow the reconstruction of the middle ear mechanics to a great extent. animal experiments and clinical experience reveal good transplantation properties of denatured and preserved ear ossicles. they are partly repla ...	1975	123985
senator bennett: where are you? any success of p.s.r.o. will be credited to him, any failure to organized medicine.		2002	124080
letter: bromide intoxication.		2002	126712
[pseudomonas aeruginosa--the causative agent of infection in birds].	pseudomonas aeruginosa was isolated from the viscera of diseased and dead birds (young and adult chickens) as well as from 9 poultry houses on seven farms. its typing was performed on the basis of the blue-green coloration of the cultures, their hemolytic activity, the pleasant odour of lime-tree, the growth in culturing at 42 degrees c, the presence of the pyocianin pigment, and the positive results of the cytochromoxidase test after gaby and hadley and the biochemical test after kovacs. the pa ...	1975	127412
cricopharyngeal sphincterotomy and bilateral division of the chorda tympani in bulbar palsy.		2002	128757
interdisciplinary early intervention program.	developmental data were obtained on 40 children with down's syndrome by an interdisciplinary team during an ongoing early intervention program. interventive methods are described. results are compared with available data on children with down's syndrome who were not in early intervention programs. comparisons of developmental progress are also made of children begun in the early intervention program before six months of age with those begun after six months of age. conclusions from the study ind ...	2002	128763
[relation between the corneal curvature and total refraction of the myopic eye].		2002	128772
[sero-epidemiological surveillance, a method of prevention of complications of streptococcal infections].	in order to find methods for the prevention and control of streptococcal infections of 711 day schoolchildren and boarders, aged 7 to 14 years, were followed up during the 1969-1973 period. the clinical and epidemiologic investigations revealed a great number of acute infections with varied clinical manifestations and high proportions of the acute articular rheumatism (3.1%) in the boarding schools as compared to the day schools (0.5%). the bacteriologic examinations confirmed and established th ...	2002	128801
[determination of the gc groups in liquid blood by vertical electrophoresis on polyacrylamide gel].		2002	129894
[caroli's syndrome].		2002	134963
[combined treatment of rheumatological patients at a health resort].		2003	154775
steroid production by quartered and capsular rat adrenal gland in response to haemorrhage.	60 min after rapid bleeding (1.5--2.0 per cent of b. w.) both aldosterone and corticosterone production rate by quartered rat adrenals were found to be elevated. however, no difference was observed in the rate of aldosterone and corticosterone production by capsular adrenals of sham operated and hypovolaemic rats. corticosterone production rate by decapsulated adrenals was much more higher after haemorrhage than in the control group. the same alterations could be observed incubating adrenal tiss ...	1975	179800
radioimmunoassay of triiodothyronine in human serum with special reference to methodological problems.	a radioimmunoassay for measuring the level of triiodothyronine in human serum has been developed and studied with respect to interference from hormone-binding substances present in human serum. dextran-coated charcoal was used for the separation of free and antibody-bound hormone. ans (8-anilino-1-naphthalenesulfonic acid) was used to reduce the interference from hormone-binding substances in serum. extraction of the hormone by ethanol before the radioimmunoassay did not solve the problem of int ...	1976	181837
effectiveness of orally administered bordetella pertussis vaccine in mice.	oral administration of killed bordetella pertussis organisms to mice results in increased resistance to an intracerebral infection with virulent b. pertussis cells. the rate of survival is dependent on the dose of antigen. but besides specific systemic immunity, which is persistent over a long period, also transient non-specific resistance is increased. these effects are evidently induced without penetration of bacterial substances into the circulation.	1976	182602
[radiolabeling of surface sialyl and galactosyl residues of zajdela's ascitic hepatoma cells].		1978	208658
a direct radioimmunoassay for tonin.	a sensitive radioimmunoassay for the measurement of tonin is described. it is based on the use of antibodies produced in rabbits against highly purified tonin obtained from rat submaxillary gland. a radioiodinated enzyme with high specific activity was obtained by the chloramine-t method. optimal conditions for radioimmunoprecipitation were established and the double-antibody method was used to separate bound and free tonin. the radioimmunoassay may be used to measure tonin in amounts as low as ...	1978	210909
[the growth curve. its interest in orthodontics. utilization of the radius of the hand].		1987	212365
presence of viral particles in the salivary gland of calomys musculinus infected with junin virus by a natural route.	calomys musculinus, a wild cricetid rodent, is one of the main reservoirs of junin virus. six of these animals were infected by being placed in close contact with animals that had been experimentally infected with the virus. they were sacrificed at 10, 15 and 20 months after contact, and their salivary glands were studied by ultrastructural, immunohistochemical and virological methods. two animals developed chronic viremia and low titers of complement-fixing antibodies. these animals were the on ...	1979	218895
informed consent--defense orthodontics.		1980	291345
development of gingivitis in pre-school children and young adults. a comparative experimental study.	earlier studies suggest that children and adults differ in the propensity to develop gingivitis when oral hygiene is abandoned. to confirm the existence of such a difference, a comparative study of pre-school children and young adults was made with objective registration methods. the author performed all registrations. after a period of intensive oral hygiene, all cleaning of teeth was discontinued for 21 days. the amount of bacterial plaque, the amount of gingival exudate and crevicular leukocy ...	2004	353084
fibrinolytic therapy for progressive systemic sclerosis and tissue fibrinolytic activity in affected skin.		2004	353113
double inferior vena cava or iliac vein occlusion? a diagnostic problem in radionuclide venograms.	radionuclide venography in two patients with suspected deep venous disease revealed double channel drainage with cross-pelvic collateral circulation. contrast inferior venacavograms revealed that one patient had persistent right and left supracardinal veins (double inferior vena cava) and the other had iliac vein occlusion with ascending lumbar collateral circulation. the similarity of radionuclide venographic findings in these two patients emphasizes the importance of contrast venacavography in ...	2004	415563
fecal bacteria in south african rural blacks and other population groups.	quantitative studies were performed on fecal flora of three population groups consuming different diets. twenty rural black south africans and 22 japanese, representing groups at low risk for carcinoma of the colon, were compared with 41 north americans from a high-risk population. specimens taken immediately after defecation were mixed and processed under anaerobic conditions. after the initial incubation, roll tubes were shipped to the united states for final identification. bacterioides and b ...	1979	447500
prophylactic infusion therapy in hemophilia.		2004	478502
[proportion of genitalia deviations in the operation material in the course of forty years (author's transl)].		2004	509277
macular oedema in the reattached retina.		2004	525278
prognistic relevance of radiation induced immune suppression in breast carcinoma.	the extent of radiation induced immune suppression was analysed in 100 patients with carcinoma of the breast. the relative changes of lymphocyte counts and stimulations by pha and ppd were similar in patients who differed with regard to age, size of tumour and its malignancy grade or axillary node condition. moreover, no difference in the degree of radiation induced immune suppression existed between patients who developed recurrent disease and those who remained free of disease during a follow- ...	2004	525447
synthesis of alpha-ketoglutarate by reductive carboxylation of succinate in veillonella, selenomonas, and bacteriodes species.	evidence for reductive carboxylation of succinate to synthesize alpha-ketoglutarate was sought in anaerobic heterotrophs from the rumen and from other anaerobic habitats. cultures were grown in media containing unlabeled energy substrates plus [14c]succinate, and synthesis of cellular glutamate with a much higher specific activity than that of cellular asparate was taken as evidence for alpha-ketoglutarate synthase activity. our results indicate alpha-ketoglutarate synthase functions in selenomo ...	1979	533772
the disposition of cyclophosphamide in a group of myeloma patients.	the disposition of cyclophosphamide and its alkylating metabolites was investigated in a group of myeloma patients with varying degrees of renal function impairment. no correlation between renal function and clearance of cyclophosphamide or its alkylating metabolites was found. no evidence of accumulation of cyclophosphamide or alkylating activity was found in four patients receiving radiolabelled cyclophosphamide. renal function was found to be related to the reciprocal of the area under curve ...	2004	535136
second reading for experiments bill.		2005	538875
[infectious endocarditis--a changing disease].		2005	544233
factors affecting production of catalase by bacteroides.	several variables affected the production of catalase by members of the "bacteroides fragilis group" of anaerobic bacteria. both media yielded higher catalase levels than the respective agar media. addition of hemin to media after autoclave sterilization, rather than before, significantly increased production of catalase. both of these variables could be related to the available hemin concentration present in the medium being tested. significantly higher amounts of hemin were required for catal ...	1978	730827
when death necessitates selling a practice.		2005	1070377
new approach to caloric stimulation of the vestibular receptor.	a new caloric testing method is described. during continuous aural irrigation, fluid is switched between hot and cold values at times computed according to a mathematical model of heat conduction in the labyrinth area. as a result, the induced temperature difference across the lateral semicircular canal describes an approximately sinusoidal time course, reaching peak values of equal magnitude but opposite sign. the magnitude of the caloric stimulus may be selected by choosing appropriate irrigat ...	1975	1081359
[effect of an oxygen-vitamin complex on general and immunological reactivity of irradiated animals].		1975	1153721
[studies on the use of wheat rich in crude proteins in the feeding of broilers. 2. carcass yields and carcass composition].	studies were made to investigate whether the the substitution of maize for high-protein wheat fed in combination with different protein in fattening rations to broilers would influence the carcass yields and chemical carcass composition of broilers. the described dietary regime was not found to have a significant influence on the different criteria of carcass composition (roaster carcass, flesh, abdominal fat, total proportion of utilizable parts) with the exception of the relative proportion of ...	1975	1233971
german multicentre study on the in vitro susceptibility of bacteroides species. the german bacteroides study group.	in 1990 the first german multicentre study on the in vitro susceptibility of bacteroides species was completed. employing a commercially prepared microbroth dilution assay, nine participating institutions evaluated approximately 100 consecutive isolates of bacteroides species from relevant clinical specimens. a total of 911 strains (449 bacteroides fragilis, 201 bacteroides thetaiotaomicron, 79 bacteroides ovatus, 78 bacteroides vulgatus, 77 bacteroides distasonis, 25 bacteroides uniformis, 2 ot ...	1992	1295762
effect of clavulanic acid, sulbactam and tazobactam on three different beta-lactamases from bacteroides uniformis, clostridium butyricum and fusobacterium nucleatum.	the effect of three beta-lactamase inhibitors, clavulanic acid, sulbactam and tazobactam used in clinical practice were compared for their activity against purified beta-lactamases from bacteroides uniformis, clostridium butyricum and fusobacterium nucleatum. the enzymes from b. uniformis and c. butyricum were produced in fermenters under controlled growth conditions and the enzyme from f. nucleatum was produced in batch cultures. purification of the beta-lactamases was achieved by anion-exchang ...	1992	1331018
effect of beta-lactamase inhibitors on beta-lactamases from anaerobic bacteria.	three beta-lactamase inhibitors in clinical use--clavulanic acid, sulbactam and tazobactam--were investigated for their activity on beta-lactamases from bacteroides uniformis, clostridium butyricum and fusobacterium nucleatum. purification of the beta-lactamases was carried out by anion-exchange chromatography, gel filtration and fplc. the inactivation of beta-lactamase activity was determined spectrophotometrically with nitrocefin as substrate. various concentrations of the inhibitors were prei ...	1992	1338315
antigen-receptor complex stimulation triggers protein kinase c-dependent cd11a/cd18-cytoskeleton association in t lymphocytes.	although it is well accepted that intercellular adhesion involving the cd11a/cd18 (lfa-1) complex is critical in a wide array of t cell-dependent processes, recent demonstrations of an lfa-1 high avidity state, induced by triggering the t cell receptor (tcr) complex, has raised questions about the intracellular signals generated and molecular events leading to effective cell coupling, as well as their orderly sequence. in this study, we assessed the effects of t cell activation on the actin-base ...	2006	1346786
recovery of bacteroides fragilis group from clinical specimens following antimicrobial therapy.	over a period of 14 years (1973-1987), 3165 specimens submitted to the microbiology laboratory demonstrated the recovery of anaerobic bacteria. a total of 988 bacteroides fragilis group isolates were recovered (0.3 isolates per specimen). bacteroides fragilis accounted for 62% of the total of all b. fragilis group isolates, bacteroides thetaiotaomicron for 15%, bacteroides vulgatus for 8%, bacteroides ovatus for 7%, bacteroides distasonis for 6%, and bacteroides uniformis for 2%. of the 988 b. f ...	1992	1393825
antibiotic sensitivity of the bacteroides fragilis group in europe. european study group.	rates of resistance to 12 antibiotics were determined for 1,289 isolates of bacteroides fragilis group submitted in 1988-1989 by 22 laboratories in 15 european countries. there was no resistance to metronidazole (breakpoint 8 mg/l) and only one isolate was resistant to chloramphenicol (breakpoint 8 mg/l). resistance was uncommon for imipenem (0.3% at greater than 4 mg/l), amoxicillin/clavulanate (1% at greater than 8 mg/l), cefoxitin (3% at greater than 32 mg/l), mezlocillin (6% at greater than ...	1992	1396748
mandatory testing?		2006	1426457
thermally-induced delayed fluorescence of photosystem i and ii chlorophyll in thermophilic cyanobacterium synechococcus elongatus.	stationary delayed fluorescence (df) of chlorophyll in isolated membrane preparations from thermophilic cyanobacterium synechococcus elongatus was investigated as a function of temperature. two peaks at different temperatures were observed. the low-temperature peak (54-60 degrees c) coincided with the main maximum of the thermally-induced delayed fluorescence of chlorophyll in intact cells and psii-particles with active oxygen-evolving system. the high-temperature peak (78 degrees c) coincided w ...	1992	1426973
how to define the opercular syndrome?		2006	1472191
doppler investigation of uteroplacental blood flow resistance in the second trimester: a screening study for pre-eclampsia and intrauterine growth retardation.		2006	1472202
external cephalic version and daily post-versional maternal self-assessment of fetal presentation. a prospective study.	external cephalic version (ecv) using tocolysis is a widely recognized low-risk intervention in cases of breech presentation, particularly in areas where resources are scarce and the perinatal mortality is high in vaginal breech deliveries. in such a setting, pregnant women were trained to make regular self-assessments of the presenting fetal part after ecv in order to detect spontaneous reversions to breech presentation. it was found that such maternal involvement could significantly improve th ...	2006	1563651
evidence for natural transfer of a tetracycline resistance gene between bacteria from the human colon and bacteria from the bovine rumen.	previously, we demonstrated conjugal transfer of a specially constructed shuttle vector, prdb5, from the human colonic anaerobe bacteroides uniformis to the ruminal anaerobe prevotella (bacteroides) ruminicola b(1)4. we have now shown that naturally occurring gene transfer elements in bacteroides species and prevotella ruminicola can also be transferred between these two genera. a self-transmissible chromosomal element originally found in a clinical isolate of bacteroides fragilis (tcr emr 12256 ...	1992	1599250
[b-cell chronic lymphocytic leukemia complicated by autoimmune thrombocytopenic purpura].	a 74-year-old japanese male was admitted because of anemia. hepatosplenomegaly, lymphoadenopathy, and purpura were not found. the laboratory data on admission revealed that the white-cell count was 9,400/microliters, the hemoglobin 11.1 g/dl, and the platelet count 17,000/microliters. platelet-associated igg was 794.2 ng/10(7) cells. the patient was diagnosed as having autoimmune thrombocytopenic purpura (atp) at this time. he was treated with prednisolone, but his thrombocytopenia not improve. ...	2006	1635169
[hypertension detection and follow-up program(hdfp)].		2006	1635190
[an epidemiology of hypertension in japanese].		2006	1635191
[etiological significance of prostaglandins and related substances in hypertension].		2006	1635208
conjugal transfer of a shuttle vector from the human colonic anaerobe bacteroides uniformis to the ruminal anaerobe prevotella (bacteroides) ruminicola b(1)4.	prevotella ruminicola (formerly bacteroides ruminicola) is an anaerobic, gram-negative, polysaccharide-degrading bacterium which is found in the rumina of cattle. since p. ruminicola is thought to make an important contribution to digestion of plant material in rumina, the ability to alter this strain genetically might help improve the efficiency of rumen fermentation. however, previously there has been no way to introduce foreign dna into p. ruminicola strains. in this study we transferred a sh ...	1991	1768083
the anti-tachycardic mechanism of a direct-acting vasodilator, budralazine, in rats.	the present study was undertaken to elucidate the anti-tachycardic effect of a direct-acting vasodilator, budralazine, using an electrophysiological technique. normotensive male wistar rats were used. rats were anesthetized intraperitoneally with urethane and alpha-chloralose. intravenous administration of budralazine (0.5-5.0 mg/kg) produced a dose-dependent reduction of mean arterial pressure in anesthetized rats. at doses of 0.5 and 1.0 mg/kg, budralazine induced bradycardia accompanied with ...	1991	1773498
effect of testosterone on the pressor response to common carotid occlusion in gonadectomized conscious male rats with lesion of the median eminence.	the influence of testosterone on the development of the pressor response to common carotid occlusion was investigated in control and median eminence-lesioned male rats. in control rats (n = 9), gonadectomy performed 21 days before the experiments reduced by 22% (from 51 +/- 2 to 40 +/- 2 mmhg) and treatment with testosterone (300 micrograms for 4 days before the measurements) increased the initial peak pressor response (from 51 +/- 2 to 57 +/- 2 mmhg) which depends on carotid innervation. the ma ...	1991	1797293
effect of testosterone on the pressor response to common carotid occlusion in gonadectomized conscious male rats with lesion of the median eminence.	the influence of testosterone on the development of the pressor response to common carotid occlusion was investigated in control and median eminence-lesioned male rats. in control rats (n = 9), gonadectomy performed 21 days before the experiments reduced by 22% (from 51 +/- 2 to 40 +/- 2 mmhg) and treatment with testosterone (300 micrograms for 4 days before the measurements) increased the initial peak pressor response (from 51 +/- 2 to 57 +/- 2 mmhg) which depends on carotid innervation. the ma ...	1991	1797293
familial fixed subaortic stenosis.	in this report, we give details of two families in which fixed subaortic stenosis was found in more than one member. it is rare for this entity to show familial incidence.	2006	1829065
time to adoption of an innovation by dentists in private practice: sealant utilization.	dentists can be divided into five adoption categories based upon their time of adoption of pit and fissure sealants: innovators, early adopters, early majority, late majority, and laggards. the differences among dentists in the five adoption categories were examined for four classes of variables: practice characteristics, dentist characteristics, communication of information, and practice environment. questionnaires were mailed in september 1984 to a random sample (n = 521) of washington state d ...	2007	1920266