Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| reconstruction after total gastrectomy: construction of a hunt-lawrence pouch using auto suture staples. | a simple gastric reservoir using autosuture staples can be constructed rapidly after total gastrectomy. the importance of both a reservoir capacity and delayed evacuation was supported by the clinical course of most of the patients. all 18 patients had improved nutrition. patients resected for cure tended to have greater weight gain and less abdominal discomfort. occasionally patients who underwent only palliative resection were long-term survivors with a clinical course similar to that of patie ... | 2001 | 88184 |
| [immunohistochemical study of the differentiation of the cephalic lobe of the adenohypophysis in chick embryos]. | it was shown by means of indirect immunofluorescence that acth appeared in the cephalic lobe of the chick embryo pituitary beginning from the 8th day of the development. a new tissue-specific antigen (a3) is revealed, which is localized in the cephalic lobe of adenohypophysis and becomes manifest at the 7th day of embryogenesis. quantitative analysis of acth and a3 localization in the cells of 11-day chick embryo adenohypophyses allows a conclusion that a3 is localized in corticotropic cells. | 2001 | 88969 |
| plasma 1,25(oh)2 vitamin d concentrations in nutritional osteomalacia. | 1999 | 89299 | |
| effects of arachidonic acid and its metabolites on antigen-induced histamine release from human basophils in vitro. | 1979 | 90097 | |
| the effect of rectal examination on serum acid phosphatase. | 2000 | 90146 | |
| antigenic relationship between influenza c viruses. | the object of this study was to determine whether antigenic groupings exist among influenza c viruses. altogether seven influenza type c strains were examined by reciprocal haemagglutination-inhibition and serum neutralization tests with sera produced in ferrets. some biological properties were also compared and differences were found in their ability to agglutinate erythrocytes from various species, in their ability to adsorb onto rat and fowl erythrocytes, and in their rates of elution from th ... | 1978 | 104696 |
| membrane changes during growth of tetrahymena in the presence of ethanol. | after a brief lag period for acclimation, tetrahymena pyriformis, strain nt-1, is capable of growing in culture medium containing high levels of ethanol. when grown in a medium having 1.6% ethanol, the membrane phospholipid composition was significantly different from that of control cells. the principal changes included a reduction in hexadecenoic acids (16 : 1 and 16 : 2) from 23% to 5% and an increase in linoleic acid (18 : 2) from 14% to 25% similar but less pronounced changes were observed ... | 1979 | 105757 |
| the lateral angiogram in the differentiation of extracerebral hematomas. | the pathophysiology of epidural hematomas is considerably different from that of subdural hematomas. epidural hematomas are well-localized intracranial masses under high pressure, whereas subdural hematomas are more widespread collections of blood under lower pressure. the underlying small cortical vessels are normal in both acute and chronic subdural hematomas but are severely distorted in epidural hematomas. the appearance of these vessels, seen best in the lateral projection, can help differe ... | 2005 | 1153776 |
| reliability of gallium brain scanning in the detection and differentiation of central nervous system lesions. | both 99mtc-pertechnetate and 67ga-citrate brain scans were performed in 93 patients with cerebral neoplasms and in 70 others with cerebral infarction or hemorrhage. tumor detection was clearly better with 67ga(96%) than with 99mtc(85%). cerebral infarctions consistently either failed to concentrate 67ga(67%) of revealed a much lower concentration than the 99mtc study (27%). in 6% of the infarction patients, gallium and technetium scans were equivalent. | 2005 | 1153779 |
| [antidepressive treatment with nortriptyline]. | 2005 | 1233907 | |
| [wound infection caused by pasteurella dagmatis following a cat scratch]. | 1992 | 1450272 | |
| characterization and distribution of pasteurella species recovered from infected humans. | during a 3-year period, all pasteurella strains recovered at the clinical microbiological laboratory, lund, sweden, were studied biochemically with respect to their relationship to the recently described taxa of this genus. of 159 strains recovered from 146 infected humans, 95 were identified as pasteurella multocida subsp. multocida, 21 as pasteurella multocida subsp. septica, 28 as pasteurella canis, 10 as pasteurella stomatis, and 5 as pasteurella dagmatis. the homology within and between the ... | 1992 | 1452670 |
| the 'bn2' gene, a regulator for the onset of chromosome condensation. | 2011 | 3067728 | |
| drug-induced nephropathy: our recent clinical experience. | 2011 | 3104006 | |
| oesophageal pain exacerbated by propranolol. | 2011 | 3113570 | |
| deficiency of eosinophil peroxidase detected by automated cytochemistry. | 2011 | 3122494 | |
| co-isolation of pasteurella dagmatis and pasteurella multocida from cat-bite wounds. | two cases of cat-bite wounds where pasteurella multocida and pasteurella dagmatis were isolated together are reported. the possibility of overlooking one species is discussed. | 1988 | 3134217 |
| high-performance liquid chromatography of the main polypeptide (mp26) of lens fiber plasma membranes solubilized with n-octyl beta-d-glucopyranoside. | the main polypeptide isolated from lens fiber membrane has been solubilized in octyl glucoside and studied by gel filtration in high-performance liquid chromatography (hplc). the combination of s20,w value obtained from analytical ultracentrifugation and stokes radius determined by hplc of the soluble fraction indicates that more than 90% of the protein is monomeric. the solubilization of the protein seems to be dependent upon the presence of the nh2 and cooh terminal sequences, since proteolyti ... | 2011 | 3164277 |
| aids testing and counseling bill. | 2011 | 3185154 | |
| physicians' decisions to limit medicaid participation: determinants and policy implications. | although most primary care physicians participate in state medicaid programs, they may accept all medicaid patients, or they may choose to limit their participation. this decision allows physicians to adjust their medicaid caseloads to a desired level, and it has important implications for the access of low-income patients to health care. surveys of pediatricians in 1978 and 1983 indicate that the proportion of pediatricians limiting their medicaid participation increased significantly from 26 p ... | 2012 | 3302000 |
| ganglion cells in the turtle retina contain the neuropeptide lant-6. | this study investigated the presence of the neurotensin-related hexapeptide, lant-6, in retinal ganglion cells and their central projections in the turtle pseudemys scripta elegans. immunocytochemical techniques demonstrated that many of the cells in the ganglion cell layer of the turtle retina could be labeled with an antiserum specific for lant-6. radioimmunoassay and chromatographic analysis confirmed the presence of lant-6-related peptides in retina, as well as brain. several molecular forms ... | 2011 | 3339403 |
| [accelerations of the fetal cardiac rhythm and fetal movements. significance of their association recorded on the cardiotocogram by the tococinon]. | recording all fetal movements on the cardiotocogram using tococinon showing forty minutes observations adds a new dimension to the old and new methods of monitoring the fetus. a group of 53 pregnancies without any risk was compared to a group of 37 pregnancies of high risk in which were also found sub-groups as designated by the aetiology and the severity of the fetal risk. furthermore we have carried out a longterm study of 5 cases over six days. we propose a choice of the best parameters to be ... | 2013 | 3584867 |
| sister-chromatid exchanges and chromosomal aberrations in a population exposed to pesticides. | sister-chromatid exchanges (sce) and chromosomal aberrations were studied in a population of floriculturists occupationally exposed to organophosphorus, carbamate and organochlorine pesticides. blood samples from 36 individuals from a community of 154 persons of asiatic origin were obtained. among the group sampled, 21 individuals exhibited at least one symptom of chronic intoxication. sce analysis was performed in 14 symptomatic and 13 asymptomatic persons. the asymptomatic group showed a sce f ... | 2014 | 4022025 |
| ipsilateral afferents to the commissural zone of the fascia dentata, demonstrated in decommissurated rats by silver impregnation. | 1971 | 4106860 | |
| [radioprotective effect of mexamine on oral administration to monkeys]. | 1973 | 4202792 | |
| mechanism of adrenaline-induced lipolysis in adipose tissue. | 1974 | 4363679 | |
| neonatal respiratory emergencies. | 2015 | 4489859 | |
| use of a cortical screw in repair of fractured mandibular symphysis in the cat. | 1974 | 4495038 | |
| a comparison of some pharmacological effects of escherichia coli (e. coli) l-asparaginase and e. coli endotoxin in rabbits. | 1973 | 4576539 | |
| [effect of lyophilized pancreatic juice on iron metabolism by rat's small intestine]. | 1972 | 4644012 | |
| [drug therapy of peripheral arterial occlusive diseases in the lower extremities using tebonin]. | 2015 | 4700951 | |
| [treatment of herpes zoster with emetine]. | 2016 | 4767947 | |
| reclassification of 30 pasteurellaceae strains isolated from rodents. | thirty pasteurellaceae strains isolated from gerbil, guineapig, hamster, mouse, muskrat and rat were reinvestigated and reclassified after comparison with reference strains. strains originally described as pasteurella pneumotropica were reclassified as [pasteurella] pneumotropica heyl biotype (7), [p.] pneumotropica jawetz biotype (1), pasteurella dagmatis (1) or taxon 22 (2). strains previously reported as actinobacillus sp. were reclassified as [p.] pneumotropica biotype jawetz (3), p. dagmati ... | 1995 | 7564217 |
| pasteurella multocida septicemia and subsequent pasteurella dagmatis septicemia in a diabetic patient. | pasteurella species may cause zoonotic infections of humans. serious systemic infections with these organisms are unusual, but they may occur in individuals with predisposing underlying illnesses. occurrences of bacteremia due to p. multocida are infrequent, and p. dagmatis bacteremia is even rarer. we report independent occurrences of p. multocida and p. dagmatis septicemia in the same diabetic patient after contact with two pet dogs. we review the history of pasteurella species and discuss the ... | 1995 | 7699042 |
| infective endocarditis due to pasteurella dagmatis: case report and review. | we report a case of endocarditis due to pasteurella dagmatis complicated by vertebral osteomyelitis in a 55-year-old former alcoholic woman. to our knowledge, this is the second report of endocarditis attributed to that organism in the english-language medical literature. rare cases of endocarditis due to other pasteurella species and their varied clinical features are summarized. | 1994 | 8011812 |
| dog-associated bacterial infections in humans: isolates submitted to an australian reference laboratory, 1981-1992. | over the period 1981-92, 32 bacterial isolates were referred to the microbiological diagnostic unit from infected dog-bite wounds and 10 isolates were submitted from blood cultures after dog bites or close contact with dogs. the isolates from the bite wounds were identified, or confirmed, as pasteurella multocida (11 isolates), pasteurella dagmatis (3), cdc group m-5 (9), cdc group ef-4a (8) and streptococcus anginosus (1). five of the 9 patients from whom cdc group m-5 was cultured had mixed in ... | 1993 | 8165003 |
| linezolid activity compared to those of selected macrolides and other agents against aerobic and anaerobic pathogens isolated from soft tissue bite infections in humans. | linezolid was tested against 420 aerobes and anaerobes, including 148 pasteurella isolates, by an agar dilution method. linezolid was active against all pasteurella multocida subsp. multocida and p. multocida subsp. septica isolates and most pasteurella canis, pasteurella dagmatis, and pasteurella stomatis isolates. the mic was </=2 microg/ml for staphylococci, streptococci, ef-4b, weeksella zoohelcum, fusobacterium nucleatum, other fusobacteria, porphyromonas spp., prevotella spp., peptostrepto ... | 1999 | 10348773 |
| pasteurella dagmatis septicaemia in an immunocompromised patient without a history of dog or cat bites. | we report a rare case of pasteurella dagmatis septicaemia in a 66-year-old immunocompromised patient, without a history of cat bites, dog bites or scratches. | 2000 | 11036682 |
| molecular identification of pasteurella dagmatis peritonitis in a patient undergoing peritoneal dialysis. | pasteurella dagmatis was identified as the etiologic agent of peritonitis in a continuous ambulatory peritoneal dialysis patient by utilizing a molecular kit in our hospital's clinical laboratory. this method would appear a useful approach to identify a species of pasteurella not included in the existing database of commercial identification kits when discrepancies exist between phenotypic tests. | 2000 | 11101625 |
| occurrence of pasteurella multocida and related species in village free ranging chickens and their animal contacts in tanzania. | investigation was done to determine the presence of pasteurella multocida and related species in free ranging chickens and ducks, dogs, cats and pigs in three climatic zones (cool, warm and hot) of rural morogoro, tanzania. a total of 153 isolates of p. multocida ssp. multocida and related species were obtained by direct culture on blood agar, selective medium and mouse inoculation. p. multocida ssp. multocida was isolated from 0.7% of chickens and 7% of ducks. in dogs and cats, p. multocida ssp ... | 2001 | 11163704 |
| genomic fingerprints, ardra profiles and quinone systems for classification of pasteurella sensu stricto. | in order to investigate the relationships between species of the genus pasteurella sensu stricto such as pasteurella multocida, pasteurella canis, pasteurella stomatis, pasteurella dagmatis, pasteurella avium, pasteurella volantium, pasteurella gallinarum, pasteurella species a, pasteurella species b and "pasteurella leonis" mccm 00659 their genomic fingerprints and ardra profiles were compared and their quinone systems were analysed. visual comparison of band patterns from rep-pcr (eric-, rep- ... | 2000 | 11249019 |
| comparative in vitro activity of ertapenem and 11 other antimicrobial agents against aerobic and anaerobic pathogens isolated from skin and soft tissue animal and human bite wound infections. | we studied the comparative in vitro activity of ertapenem, a new carbapenem, against 240 aerobic and 180 anaerobic recent clinical bite isolates using an agar dilution method and an inoculum of 10(4) cfu/spot for aerobes and 10(5) cfu/spot for anaerobes. ertapenem inhibited 410/420 (98%) of the isolates tested at < or = 4 mg/l with only 4/5 campylobacter gracilis and 1/3 campylobacter rectus strains requiring . or = 16 mg/l for inhibition. ertapenem was only moderately active (mic 8 mg/l) agains ... | 2001 | 11679553 |
| prosthetic valve endocarditis caused by pasteurella dagmatis. | this case of prosthetic valve endocarditis due to pasteurella dagmatis is the first to be reported in the english language medical literature. the two reported cases of native valve endocarditis due to p dagmatis are reviewed, and the treatment of pasteurella-induced endocarditis is discussed. | 2001 | 11702818 |
| fatal pasteurella dagmatis peritonitis and septicaemia in a patient with cirrhosis: a case report and review of the literature. | pasteurella species cause zoonotic infections in humans. human pasteurella infections usually manifest as local skin or soft tissue infection following an animal bite or scratch. systemic infections are less common and are limited to patients at the extremes of age or those who have serious underlying disorders, including cirrhosis. most human pasteurella infections are caused by the multocida species. we report a case of pasteurella dagmatis peritonitis and septicaemia in a patient with cirrhos ... | 2004 | 14747455 |
| rapid and accurate identification of human isolates of pasteurella and related species by sequencing the soda gene. | the identification of pasteurella and related bacteria remains a challenge. here, a 449- to 473-bp fragment (soda(int)) internal to the soda gene, encoding the manganese-dependent superoxide dismutase, was amplified and sequenced with a single pair of degenerate primers from the type strains of pasteurella (18 strains), gallibacterium (1 strain), and mannheimia (5 strains) species. the soda(int)-based phylogenetic tree was in general agreement with that inferred from the analysis of the correspo ... | 2005 | 15872260 |
| long-term respiratory tract infection with canine-associated pasteurella dagmatis and neisseria canis in a patient with chronic bronchiectasis. | pasteurella dagmatis and neisseria canis were repeatedly isolated from the sputum of a poodle-owning patient with chronic bronchiectasis. commercially available systems failed to identify these unusual organisms: identification was made by 16s rrna gene sequencing. difficulties identifying these and five other canine-associated isolates (p. dagmatis [n = 2], pasteurella canis [n = 2], and n. canis [n = 1]) are discussed. | 2005 | 16081998 |
| [pasteurella dagmatis spondylodiscitis in a diabetic patient]. | healthy pets contact are able to induce unusual and severe diseases. | 2006 | 16978746 |
| [pasteurella dagmatis: an unusual cause of vertebral osteomyelitis]. | vertebral osteomyelitis is a quite rare but severe cause of back pain in adults. various causative organisms have been reported. pasteurella species have rarely been isolated. we report here a case of vertebral osteomyelitis and consecutive cauda equina syndrome due to pasteurella dagmatis in a 60-year-old diabetic man. | 2007 | 17391865 |
| dog bite wound infection by pasteurella dagmatis misidentified as pasteurella pneumotropica by automated system vitek 2. | 2009 | 19765934 | |
| characterisation of pasteurella dagmatis-like isolates recovered from the feline oral cavity. | three pasteurella dagmatis-like strains recovered from the feline oral cavity were analysed by traditional biochemical tests, the biolog microstation™ id system, and 16s rrna and soda gene sequence analysis. the molecular biological methods revealed that these strains differ from p. dagmatis, forming a new genomospecies in the genus pasteurella sensu stricto. furthermore, sequence analysis and multiple alignments of 16s rrna and the soda gene established that the p. pneumotropica nctc10827 and t ... | 2010 | 20409650 |
| molecular identification of bacteria associated with canine periodontal disease. | periodontal disease is one of the most common diseases of adult dogs, with up to 80% of animals affected. the aetiology of the disease is poorly studied, although bacteria are known to play a major role. the purpose of this study was to identify the bacteria associated with canine gingivitis and periodontitis and to compare this with the normal oral flora. swabs were obtained from the gingival margin of three dogs with gingivitis and three orally healthy controls, and subgingival plaque was coll ... | 2011 | 21489726 |
| genetic diversity of pasteurella dagmatis as assessed by analysis of the 16s rrna and rpob gene sequences. | a total of 16 pasteurella dagmatis strains, including 11 feline and 4 canine isolates as well as one strain isolated from a tiger, were analyzed using partial 16s rrna and rpob gene sequence comparison. phylogenetic studies based on both genes revealed that the population of p. dagmatis recovered from cats in poland differs markedly from canine strains, constituting a well-separated cluster within pasteurella sensu stricto species group. the isolate from a tiger seems to represent yet another ev ... | 2011 | 21573831 |
| polymerase chain reaction-based identification of clinically relevant pasteurellaceae isolated from cats and dogs in poland. | a set of polymerase chain reaction (pcr) assays for identification of the most important pasteurellaceae species encountered in cats and dogs were developed. primers for pasteurella multocida were designed to detect a fragment of the kmt, a gene encoding the outer-membrane protein. primers specific to pasteurella canis, pasteurella dagmatis, and pasteurella stomatis were based on the manganese-dependent superoxide dismutase gene (soda) and those specific to [haemophilus] haemoglobinophilus on sp ... | 2011 | 21908285 |
| a case of wound dual infection with pasteurella dagmatis and pasteurella canis resulting from a dog bite - limitations of vitek-2 system in exact identification of pasteurella species. | background: pasteurella species, widely known as indigenous organisms in the oral and gastrointestinal floras of many wild and domestic animals, are important pathogens in both animals and humans. human infections due to pasteurella species are in most cases associated with infected injuries following animal bites. we encountered a rare case of dual infections caused by different two pasteurella species occurred in a previously healthy 25-year-old female sustaining injury by a dog-bite. - method ... | 2011 | 22112359 |
| [staphylococcus pseudintermedius and pasteurella dagmatis associated in a case of community-acquired pneumonia]. | 2012 | 22366256 | |
| prosthetic valve endocarditis caused by a pasteurella dagmatis-like isolate originating from a patient's cat. | pasteurella species are part of the oral flora of cats and dogs. in humans, they are frequently found in infected animal bite wounds, but invasive infections are rare. this is the first report of prosthetic-valve endocarditis with a pasteurella dagmatis-like species, which originated from the patient's cat. | 2012 | 22675130 |
| pasteurella infection after muraenidae bite in an hiv infected patient. | we report a case of pasteurella dagmatis wound infection in an immunocompromised hiv infected patient after bite by a marine carnivore in caribbean sea (dominican republic), presumably a muraenidae. identification of the pasteurella species from wound sampling was obtained twice by mass spectrometry and confirmed by 16s rna sequencing. | 2013 | 23608461 |
| characterization of a multifunctional α2,3-sialyltransferase from pasteurella dagmatis. | a new multifunctional α2,3-sialyltransferase has been discovered in pasteurella dagmatis. the enzyme, in short pdst, was identified from the p. dagmatis genome by sequence similarity with sialyltransferases of glycosyltransferase family gt-80. in addition to its regioselective sialyltransferase activity (5.9 u/mg; ph 8.0), purified pdst is alternatively active at low ph as α2,3-sialidase (0.5 u/mg; ph 4.5) and α2,3-trans-sialidase (1.0 u/mg; ph 4.5). it also shows cytidine-5'-monophosphate n-ace ... | 2013 | 23969291 |
| mechanistic study of cmp-neu5ac hydrolysis by α2,3-sialyltransferase from pasteurella dagmatis. | bacterial sialyltransferases of the glycosyltransferase family gt-80 exhibit pronounced hydrolase activity toward cmp-activated sialyl donor substrates. using in situ proton nmr, we show that hydrolysis of cmp-neu5ac by pasteurella dagmatis α2,3-sialyltransferase (pdst) occurs with axial-to-equatorial inversion of the configuration at the anomeric center to release the α-neu5ac product. we propose a catalytic reaction through a single displacement-like mechanism where water replaces the sugar su ... | 2014 | 24945729 |
| [isolation of pasteurella dagmatis after a tiger bite]. | 2014 | 25536431 | |
| complete switch from α-2,3- to α-2,6-regioselectivity in pasteurella dagmatis β-d-galactoside sialyltransferase by active-site redesign. | structure-guided active-site redesign of a family gt-80 β-d-galactoside sialyltransferase (from pasteurella dagmatis) to change enzyme regioselectivity from α-2,3 in the wild type to α-2,6 in a p7h-m117a double mutant is reported. biochemical data for sialylation of lactose together with protein crystal structures demonstrate highly precise enzyme engineering. | 2015 | 25619424 |
| [pasteurella dagmatis bacteremia in a cirrhotic patient: beware of contact with domestic pets]. | 2017 | 25703210 | |
| occurrence of pasteurellaceae bacteria in the oral cavity of the tasmanian devil (sarcophilus harrisii). | the occurrence of bacteria belonging to the family pasteurellaceae in the oral cavity of captive tasmanian devils (sarcophilus harrisii) was investigated using phenotypic and subsequent genotypic characterization and phylogenetic analyses. a total of 62 bacterial isolates obtained from tasmanian devils, tentatively classified with the family pasteurellaceae, were further characterized by phylogenetic analysis of rpob gene sequence similarity, which showed that the isolates investigated formed fi ... | 2015 | 26056874 |
| a semi-multifunctional sialyltransferase from bibersteinia trehalosi and its comparison to the pasteurella multocida st1 mutants. | sialic acids are well known for their crucial roles in many physiological and pathological processes. improvement in the efficacy of protein drugs, an increase in the anti-inflammatory activity of intravenous immunoglobulin, preparation of infant milk and the diagnosis of diseases are examples of why there is a need for efficient in vitro sialylation. sialyltransferases are crucial enzymes for the synthesis of sialo-oligosaccharides. here, we introduce a new α2,3-sialyltransferase from bacteria ... | 2015 | 26477829 |
| bacteremia due to pasteurella dagmatis acquired from a dog bite, with a review of systemic infections and challenges in laboratory identification. | a case of bacteremia in a 74-year-old man, which was caused by pasteurella dagmatis and complicated by thrombocytopenia, is presented. microorganism identification was performed by the provincial reference laboratory using traditional biochemical profiling, completmented with both the sequencing of the 16s ribosomal rna gene and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; antibiotic-susceptibility testing was also performed. after treatment with the appropriate ... | 2017 | 26600817 |
| identification of members of the pasteurellaceae isolated from birds and characterization of two new taxa isolated from psittacine birds. | a collection of 43 unclassified members of the pasteurellaceae, most of which were obtained from lesions, were investigated using an extensive battery of phenotypical tests as well as by ribotyping. the isolates had been made from anser anser forma (f) domestica (d), agapornis fischer, amazona spp., ara macao, columba livia f.d., melanopsittacus undulatus, and psittacus erithacus. comparison of results with those obtained from reference strains allowed classification of 25 strains. three strains ... | 1999 | 26905494 |
| in vitro activity of pexiganan and 10 comparator antimicrobials against 234 isolates including 93 pasteurella spp. and 50 anaerobic bacteria recovered from animal bite wounds. | animal bite wounds affect more than 5 million americans resulting in 300,000 emergency department visits, 10,000 hospitalizations and untold number of physician office visits annually. various forms of topical therapy are empirically self-employed by many patients prior to seeking medical attention. pexiganan, a 22-amino acid synthetic cationic analogue of peptide magainin ii, acts by selectively damaging bacterial cell membranes. we determined the mics for pexiganan and other antimicrobial agen ... | 2017 | 28373186 |
| active-site his85 of pasteurella dagmatis sialyltransferase facilitates productive sialyl transfer and so prevents futile hydrolysis of cmp-neu5ac. | sialyltransferases of the gt-80 glycosyltransferase family are considered multifunctional because of the array of activities detected. they exhibit glycosyl transfer, trans-sialylation, and hydrolysis activities. how these enzymes utilize their active-site residues in balancing the different enzymatic activities is not well understood. in this study of pasteurella dagmatis α2,3sialyltransferase, we show that the conserved his85 controls efficiency and selectivity of the sialyl transfer. a his85→ ... | 2017 | 28474804 |