Publications

[perichordal necroses. contribution to the understanding of the spinal column morphogenesis].	in 12--15 days old rat embryos and 12 days old mouse embryos vitally stained by acridin orange, a perichordal necrosis appears, showing metameric intensifications at the level of the dense sclerotomites. similar aspects were detected in serially sectioned rabbit and human embryos (6--7 mm c.r. length). the authors correlate the necrotic zones mentioned with the inductive functions of the notochord.	1978	86154
the rubella immunity gap.		2001	87852
cross-reactions between haemophilus influenzae and nineteen other bacterial species.	forty-one different antigens were demonstrated in an antigen preparation obtained by sonication of a haemophilus influenzae (h. influenzae) type b strain, using crossed immunoelectrophoresis and antiserum obtained from rabbits. antigens were characterized by absorption experiments with whole heat-killed bacteria, temperature resistance and protein and polysaccharide staining. cross-reactions between h. influenzae type b and 19 other bacterial species were studied by various quantitative immunoel ...	1979	94235
evidence for involvement of microtubules in the action of vasopressin in toad urinary bladder. ii. colchicine binding properties of toad bladder epithelial cell tubulin.	colchicine, podophyllotoxin and vinblastine have been found to inhibit the action of vasopressin on water movement in the toad urinary bladder. tubulin is the major colchicine binding component of toad bladder epithelial cells, accounting for approximately 3.3% of the total cell protein. more than 99% of the tubulin is found in the soluble fraction after sonication, the remainder is in the particulate fraction. similar to the characteristics of the binding of colchicine to tubulins from other so ...	1999	96270
radiology societies.		1998	104596
thrombosis after parenteral feeding via a subclavian catheter.		2002	117292
muscle stretch and chemical muscle spindle excitation: effects on renshaw cells and efficiency of recurrent inhibition.		1976	137423
dermatofibrosarcoma protuberans in northern nigeria: a clinico-pathological review of 17 cases.		2003	149627
[dynamics of sleep and the waking state after labyrinthine deafferentation].	the author carried out studies on awake state and sleep (slow and paradoxal) after lybyrinth deafferentation. the states were evaluated by behavior, eeg, myogram and eye movements. the labyrinth defferentation was performed in combination (chemical and mechanical). bilateral labyrinth deafferentation reduced the duration of the awake state from 30% to 17%, p less than 0.001. the slow sleep was increased at the same time but there was no statistical significance. the parodoxal sleep was due both ...	1976	179775
radiometric detection of haemophilus in simulated blood cultures.	the radiometric detection of various haemophilus species was studied in simulated blood cultures and in blood culture media without added blood, but supplemented with nicotinamide-adenine dinucleotide (nad) or hemin, or both. haemophilus aphrophilus was the only species studied that was radiometrically detectable without added blood or nad. all other species studied (haemophilus influenzae, haemophilus parainfluenzae, haemophilus haemolyticus, and haemophilus parahaemolyticus) required either ad ...	1979	218444
quantitative evidence for the helicoid relationship between the maxillary and mandibular occlusal surfaces.	a method for measuring the transverse inclination of molar teeth is described which enabled significant differences (p less than 0.001) between the three molars to be demonstrated for a sample of english modern (n 24) and romano-british (n20) skulls. no significant differences between the transverse molar inclinations were found for the bronze age (n 10) or the neanderthal (n 8) sample.	2004	321732
cloning of restriction and modification genes in e. coli: the hbaii system from haemophilus haemolyticus.	the genes for a class ii restriction-modification system (hhaii) from haemophilus haemolyticus have been cloned in escherichia coli. the vector used for cloning was plasmid pbr322 which confers resistance to tetracycline and ampicillin and contains a single endonuclease r-psti site, (formula: see text), in the ampicillin gene. the procedure developed by bolivar et al. (1977) was used to form dna recombinants. h. haemolyticus dna was cleaved with psti endonuclease and poly(dc) extensions were add ...	1978	350714
wildrid beric beauvais southwell, t.d., l.d.s.		2004	356861
characterization of plasmids from haemophilus parainfluenzae and haemophilus haemolyticus.		1979	384428
moorcroft: the first modern eye-surgeon in punjab.		2004	387585
chlamydial genital infections: a growing problem.		1979	478491
purine transport and the cell cycle.		2005	546160
the structure of brevistin. studies on antibiotics from the genus bacillus. x.	acid hydrolysis revealed the constituent amino acids by brevistin as follows: aspartic acid (d-form 2, l-form 1), l-threonine (1), glycine (1), sum of l-valine and l-isoleucine (1), l-phenylalanine (1), l-trytophan (1), and 2,4-diaminobutyric acid (d-form 1, l-form 1). the constituent fatty acid was elucidated to be anteisononanoic acid by gas chromatography-mass spectrometry. a lactone linkage was proved between phenylalanine and the hydroxy group of threonine. opening the lactone ring with dil ...	1976	931806
a specific endonuclease from haemophilus haemolyticus.		1976	1085372
cleavage map of bacteriophage phix174 rf dna by restriction enzymes.	phix rf dna was cleaved by restriction enzymes from haemophilus influenzae rf (hinf i) and haemophilus haemolyticus (hha. i). twenty one fragments of approximately 25 to 730 base pairs were produced by hinf i and seventeen fragments of approximately 40 to 1560 base pairs by hha i. the order of these fragments has been established by digestion on haemophilus awgyptius (hae iii) and arthrobacter luteus (alu i) endonuclease fragments of phix rf with hinf i and hha1. by this method of reciprocal dig ...	1976	1085927
a genetic study of plasma dopamine beta-hydroxylase in affective disorder.	plasma dbh activity was studied in patients with affective illness (unipolar or bipolar) and in their families. we found diagnosis, mood state or lithium treatment did not modify plasma dbh activity. in family studies we found same-sex siblings to show significant correlations for plasma dbh activity regardless of diagnosis. monozygotic twins had almost identical dbh activities; 4 pairs of monozygotic twins discordant for affective illness were concordant for dhb activity. the heritability estim ...	2005	1177948
changes in vascular permeability associated with acetic acid-induced gastrin ulcer in rats.	gastric ulcer was induced in rats by application of acetic acid to the anterior wall of the stomach. leakage of circulating albumin into the gastric wall was estimated by intravenous injection of radioactive albumin and determination of the radioactivity in different samples of the stomach wall. the protein leakage was found to be markedly increased in the anterior wall of the stomach, the increase being most pronounced close to the ulcer. the leakage remained fairly constant during the first 10 ...	1976	1248499
gene transfer, replacement and augmentation. keystone symposia on molecular and cellular biology. april 3-9, 1992. abstracts.		2006	1351967
calcium oxalate crystals in breast biopsies. the missing microcalcifications.	most calcifications detected by mammography and specimen radiography are readily identified by histologic sections stained with hematoxylin and eosin (h&e) or the von kossa stain. however, calcifications composed of calcium oxalate crystals are not always seen in sections stained with h&e or with von kossa. to study the incidence of calcium oxalate crystals in breast biopsies, we used polarized light microscopy to review 153 needle-localization breast biopsies. birefringent crystals were observe ...	2006	1698342
quantitative study of striate single unit responses in monkeys performing an orientation discrimination task.	contour orientation discrimination accuracy is determined by the orientation bandwidth, response variance and response strength of single units that code for orientation. we measured the latter three properties for v1 cells of monkeys which were performing an orientation discrimination of the grating stimulating the cell under study. we recorded from 285 cells, of which 76% responded to the grating. the orientation bandwidth, measured as full width at half height of the tuning curve, varied over ...	1991	1855551
in the aftermath: health care in kuwait city.		2007	1865865
[evaluation of collagenous protein levels in inflamed middle ear mucosa].	the collagenous protein level in the inflammatory status of middle ear mucosa taken during the surgery in 16 patients were analysed. the more accentuated changes were in longer duration of disease. the collagenous protein level play probably an important role in the healing processes after tympanoplasty.	2007	1896187
general practice as a career.		2007	1932976
repeated community-based chemotherapy for the control of schistosoma mansoni: effect of screening and selective treatment on prevalences and intensities of infection.	the impact of repeated selective chemotherapy on prevalences and intensities of infection with schistosoma mansoni was evaluated in gihungwe transversals 1 and 2 (initial prevalence 60%) and buhandagaza/kizina (initial prevalence 35%), two village clusters in burundi. surveys were carried out at months -6, -3, 0, 3, 6, 9, 12, 24, and 36, with reference to the first intervention; treatment with praziquantel (40 mg/kg) was given at months 0, 12, 24, and 36 to subjects showing parasite eggs on a si ...	1991	1951860
continuous infusion of halogenated pyrimidines.		2007	2045313
pneumoperitoneum and pneumomediastinum: unusual complications of laparoscopy.	pneumoretroperitoneum and pneumomediastinum are rare complications of laparoscopy. we report one such case. the mechanism of development of these complications is explained. no specific treatment needs to be instituted in most of these patients.	2007	2151452
diabetes-related changes in brain beta adrenoreceptors in rats as assessed by quantitative autoradiography: relationship to hypothalamic norepinephrine metabolism and pituitary-gonadal hormone secretion.	streptozotocin (stz)-induced diabetes produced significant and selective alterations in brain beta adrenoreceptor subtypes, norepinephrine (ne) metabolism and pituitary-testicular hormone in male rats. the densities of beta-1 but not beta-2 adrenoreceptors were increased in hypothalamus (anterior and lateral nuclei), thalamus (ventral posterior nucleus) and amygdala (basolateral nucleus) of the stz diabetic rats. in contrast, a decrease in the rate of metabolism of ne (estimated by the concentra ...	1990	2168485
comparison of the rim-h rapid identification kit with conventional tests for the identification of haemophilus spp.	a commercially available system, the rim-h system (austin biological laboratories, austin, tex.), was evaluated for its ability to rapidly and accurately identify various haemophilus spp. a total of 110 clinical isolates were tested by both the rim and conventional identification procedures. the rim agreed with the standard identification for 100% of the haemophilus influenzae (76 of 76) and 92.0% of the haemophilus parainfluenzae (23 of 25) isolates tested. the identifications of haemophilus pa ...	1990	2203817
evaluation of bcg at birth in the united arab emirates.	a total of 387 healthy full term infants who received bcg vaccination at birth were evaluated by the tuberculin ppd test at 6-8 weeks post vaccination. a total of 92% of these infants had visible bcg scars at that time. all infants were tested with ppd but only 264 returned for the test to be read. the tuberculin test was negative in 37 (14%) and of less than 5 mm induration in another 60 (23%) of the infants. the same pattern was observed in different nationalities. of 11 infants with no bcg sc ...	1990	2238123
evaluation of bcg at birth in the united arab emirates.	a total of 387 healthy full term infants who received bcg vaccination at birth were evaluated by the tuberculin ppd test at 6-8 weeks post vaccination. a total of 92% of these infants had visible bcg scars at that time. all infants were tested with ppd but only 264 returned for the test to be read. the tuberculin test was negative in 37 (14%) and of less than 5 mm induration in another 60 (23%) of the infants. the same pattern was observed in different nationalities. of 11 infants with no bcg sc ...	1990	2238123
mrna coding for oxytocin is present in axons of the hypothalamo-neurohypophysial tract.	neuronal mrna is thought to be restricted to perikaryal and dendritic compartments containing rough endoplasmic reticulum. we have used both in situ hybridization and dna polymerase chain reaction methods to determine the precise intracellular distribution of oxytocin mrna. using light- and electron-microscopic detection of in situ hybridization with 5'-bromo-2'-deoxyuridine-labeled oligonucleotide probes, we found oxytocin mrna in axons and herring bodies in the lateral and ventral hypothalamus ...	1990	2268384
[review of the present status of prevention, prophylaxis and therapy of pertussis and parapertussis].	whooping cough is endemic throughout the world. it becomes epidemic every 4-5 years (yugoslavia 3-4 yrs). in europe its incidence ranges from 0.4 (hungary) to even 59/100.000 inhabitants (rumania; yugoslavia 28), with a general letality of 0.1% (infants: 1%; 75% children who die are younger than one yr). only 5-10% cases are supposed to be registered. a low socioeconomic status is more and more emphasized as the principal risk factor. its transmission rate is high (home contacts: 80-100%); infec ...	1990	2292902
[the role of veterinary toxicology in farm animals].	the history of veterinary toxicology in farm animals, like that of human toxicology, is marked by a number of classical, large-scale cases of poisoning, which have become widely known. a number of these cases are briefly reported, attention being drawn to the specific problems to which they give rise. publicity, liability, diagnostic problems and amount of loss often have a delaying effect on settlements. methods which might improve this situation are broadly outlined.	1990	2396243
separation of branched sialylated oligosaccharides using high-ph anion-exchange chromatography with pulsed amperometric detection.	ten characterized sialylated oligosaccharides from bovine fetuin (b. bendiak, m. harris-brandts, s. w. michnick, j. p. carver, and d. a. cumming, biochemistry, in press; and d. a. cumming, c. g. hellerqvist, m. harris-brandts, s. w. michnick, j. p. carver, and b. bendiak, biochemistry, in press) were chromatographed using high-performance anion-exchange chromatography with pulsed amperometric detection. at near neutral ph values, oligosaccharides were separated according to their number of forma ...	1989	2481411
[demographic trends: birth spacing].	two studies to measure children spacing in western metropolitan santiago are compared. the first (1984-85) surveyed a sample of 687 mothers and the second 1,000. deliveries took place at san juan de dios and félix bulnes hospitals (both state-finance) which provide medical care for medium and low income groups. long spacing (5 years or more) accounted for the highest proportion of non-first born children (33.8% in 1984-85 with a significant increase to 40.1% in 1988) while short spacing (under 2 ...	2008	2519406
[the psychology of the tuberculosis patient in different historical periods and its repercussions in social life, art and customs].		2008	2519493
standards of morphological development in fetuses and newborns as a method of defining fetal age.	whenever the calendar age of the studied fetal material is not known we are bound to reconstruct it by replacing it with the developmental age. in this paper some common developmental standards used in the determination of fetal age are reviewed. the standards, as found in the relevant literature, are tested against a control group for their accuracy in predicting fetal age. the results indicate considerable discrepancy among the various standards. further, the developmental ages defined by thes ...	2008	2603470
[aspects of the popular attitude about diarrhea among tswana-speaking urbanites].	this article contains a general overview of cultural perceptions of diarrhoeal disease amongst infants as expressed by tswana-speaking urbanites. attention is mainly given to the perception of gastro-enteritis. the research on which this article is based was concluded during 1984. the article indicates that a majority of respondents maintains the view that aetiologically it is possible to distinguish between three categories of illness, viz. illness of sorcery, illness of the shades or ancestors ...	2008	2632096
promoting activity of betel quid ingredients and their inhibition by retinol.	ingredients of betel quids, which have been linked to the high incidence of precancerous oral lesions and oral cancers, were examined for their promoting activity. aqueous extracts were tested using the bovine papillomavirus (bpv) dna transformation assay, which consists of cultured c3h/10t1/2 cells transfected with the plasmid pdpbv-1 as targets, and the frequency of transformed foci as endpoints. areca nut extracts enhanced the formation of bpv dna-induced transformed foci approximately tenfol ...	1989	2713825
extraterrestrial amino acids in cretaceous/tertiary boundary sediments at stevns klint, denmark.	since the discovery nearly a decade ago that cretaceous/tertiary (k/t) boundary layers are greatly enriched in iridium, a rare element in the earth's crust, there has been intense controversy on the relationship between this ir anomaly and the massive extinction of organisms ranging from dinosaurs to marine plankton that characterizes the k/t boundary. convincing evidence suggests that both the ir spike and the extinction event were caused by the collision of a large bolide (greater than 10 km i ...	2009	2725679
[experimental validation of the expediency of the use of ultra-high frequency therapy in combination with antibacterial drugs in infiltrative tuberculosis of the lungs].	the influence of the u.h.f. electric field in combination with specific antibacterial therapy on the character of morphological shifts, isoniazid accumulation, collagen fractional composition and tubercle bacilli population in the foci of infiltrative tuberculosis of the lungs was studied experimentally. the effect of this preformed physical factor on the process of tuberculosis was shown to be favourable. under the action of the u.h.f. electric field microcirculation in the lungs improved, and ...	1989	2726711
[construction and testing of a strain gauge for measuring masticatory force].	the main objective of this study was to establish and test a measuring system for monitoring occlusal forces and force cycles during mastication. a measuring module using strain gauge transducers was incorporated in the bridge-pontic of a three part test bridgework. a load cell was used intraorally for loading and calibration. the test bridges were incorporated in the patient's mouth and calibrated in vivo using variable loads. the recording system was a special intensifying and processing syste ...	2009	2772595
clinical evaluation of propofol as an intravenous anaesthetic agent in cats and dogs.	the clinical efficacy and safety of an emulsion containing 10 mg/ml of the intravenous anaesthetic propofol were evaluated in cats and dogs by veterinary surgeons in eight practices in the united kingdom. a total of 290 dogs and 207 cats were anaesthetised with propofol either as a single injection for procedures of short duration, or as an induction agent with maintenance provided by further incremental injections or as an induction agent with maintenance by gaseous agents. the mean induction d ...	1989	2783794
nuclear factor 1 (nf-1) binding sites in the genomes of human oncoviruses: a hypothetic role for reintegrated cellular origins of replication in malignant transformation.	we have found that genomes of human t cell leukemia-lymphoma virus type i (htlv-i), bk virus (bkv), and a hepatitis b virus (hbv) dna sequence integrated into dna of a hepatoma-derived cell line contain binding sites for nuclear factor 1 (nf-1), a cellular protein which binds to adenoviral and putative cellular origins of dna replication. we suggest that cellular origins of dna replication acquired by oncoviruses may play a role in malignant transformation after reintegration into the cellular g ...	1988	2830475
isolation of haem-bearing peptides of haem proteins by the use of adsorption chromatography.		1987	2832428
radiological findings in small-bowel tumours.	radiological findings were evaluated in a series of 25 cases with malignant and three with benign small bowel tumours with surgical or autopsy confirmation of diagnosis. 27 patients were operated, two of them without any radiography due to 'acute abdomen'. 23 patients were examined with ultrasound, 14 with barium examination, seven with ct, four with plain films and two with angiography. ultrasound revealed 16 (70%) out of 23 tumours, in two cases result was abnormal but the tumour was not found ...	2009	2849159
[undiagnosed posterior dislocation of the shoulder].		2010	2897511
coagulation factor viii concentrates and the marketplace.		2010	2897528
high prevalence of trichomona infections in adolescents.		2010	2910629
an anthropometric assessment of huntington's disease patients and families.	an anthropometric investigation was designed to evaluate patterns of physical deterioration in huntington's disease (hd). in this study a comprehensive set of measurements was taken including height, weight, body circumferences, skinfold thickness, and craniofacial, linear, and breadth components of the body, on 44 normal, 26 affected, and 70 at-risk individuals between 14 and 88 years of age. the anthropometric data were converted to z-scores using standards to adjust for age and sex difference ...	2010	2932916
[various indices of the immunologic reorganization of the body in allergic dermatitis].		1987	2953139
complement-dependent triggering of b-cells, t-cells and macrophages.		2010	2957999
veralipride: alternative antidopaminergic treatment for menopausal symptoms.	the vasomotor hot flushes and increased perspiration symptomatic of the menopausal period reflect the adaptation of the body to the lowering of its preset basal temperature resulting from the interference of various central neurotransmitters of suprahypothalamohypophyseal origin. the present double-blind study was conducted to test the efficacy of veralipride, a synthetic antidopaminergic molecule, in eliminating the symptoms of menopause in 50 patients. results indicated a total elimination of ...	2010	2967034
[which therapeutic attitude should be adopted in the presence of non-small cell bronchopulmonary cancer?].	complete surgical excision is the best method of obtaining cure. however, this is only possible in less than one quarter of the patients. in all of the other patients, the hopes for cure are based on combinations of chemotherapy-radiotherapy-surgery, in particular preoperative chemotherapy. phase ii trials of chemotherapy are underway. real progress will only be achieved when joint multicentric studies can be conducted.	2010	2992063
accuracy and time requirements for use of three rapid theophylline assay methods.		2010	3042269
accuracy and time requirements for use of three rapid theophylline assay methods.		2010	3042269
age and infertility.		2011	3105771
age and infertility.		2011	3105771
[primary leiomyosarcoma of the pulmonary artery. apropos of a case].	a case of leiomyosarcoma of the pulmonary artery in a 64-year old man without previous cardiovascular disease is reported. the clinical picture, which comprised episodes of paroxysmal dyspnoea associated with acute cor pulmonale, suggested pulmonary embolism. radioisotope perfusion study and pulmonary angiography seemed to confirm this diagnosis, but no improvement was obtained with a prolonged thrombolytic treatment. the presence of a median mass at ct led to exploratory thoracotomy and to the ...	1987	3122693
pretreatment with icrf-187 allows a marked increase in the total cumulative dose of doxorubicin tolerated by beagle dogs.	to study the influence of icrf-187 on the functional and morphological effects of very large cumulative doses of doxorubicin, adult beagle dogs were given doxorubicin (1.75 mg/kg i.v.) either alone or 15 min after icrf-187 (25 mg/kg, i.v.) at 3-week intervals. control dogs received icrf-187 (25 mg/kg, i.v.) or 0.9% saline without doxorubicin. of eight animals receiving doxorubicin alone, two died after a total dose of 12.25 mg/kg and three died after 14 mg/kg; three others were in poor condition ...	1988	3147886
insurance company policies.		2011	3164732
cleavage lines of the oral mucosa in japanese cadavers.	cleavage lines were experimentally reproduced in the oral mucosa of japanese cadavers. they were investigated macroscopically and histologically. the reproduced cleavage lines showed little directional variation by sex or age. from the histological findings, the mucosal cleavage lines were interpreted to represent cleavage split along the direction of connective tissue fibres in the lamina propria.	2011	3165386
[laboratory and clinical studies of rokitamycin dry syrup in the field of pediatrics].	laboratory and clinical studies on rokitamycin (rkm) dry syrup, a new macrolide antibiotic, were carried out in the field of pediatrics. the results are summarized as follows. 1. plasma concentrations and urinary recovery rates after oral administration on fasting of rkm dry syrup at doses of 10 mg/kg and 20 mg/kg to 2 and 1 cases, respectively, were determined. peak plasma levels were obtained in 30 minutes after administration of both dosages with half-lives of 1.5 to 2.2 hours. a clear-cut do ...	1988	3172461
the flavonoid silymarin increases the permeability of rat bone marrow cells to (3h)-uridine.	the pretreatment of rats with the flavonoid silymarin increases the in vitro uptake of (3h)-uridine to bone marrow cell rna. this stimulatory effect is unrelated to an increase in the activity of cellular polymerases. it is proposed that the flavonoid enhances the permeability of the cell to (3h)-uridine acting at the membrane level.	1988	3187195
assessment of reproductive risks and intentions by mothers of children with hemophilia.	thirty-five mothers of children with hemophilia were studied in order to ascertain the impact of hemophilia on family planning. attitudes about reproductive risks and prenatal diagnosis were also examined. the most important factors influencing family planning in this group were parental fulfillment and availability of medical care and education for their affected child. although 79% of mothers viewed their reproductive risk as moderate to very high, 57% indicated that their reproductive plans h ...	2011	3232693
an improved method for the simultaneous determination of morphine and its principal glucuronide metabolites.		2011	3235512
overproduction and purification of the m.hhaii methyltransferase from haemophilus haemolyticus.	the hhaii methyltransferase gene from haemophilus haemolyticus was subcloned in an expression vector under control of the hybrid trp-lac promoter. induction with isopropyl-beta-d-thiogalactopyranoside results in overproduction of the methyltransferase to about 3% of total cellular protein. the methyltransferase was purified to near electrophoretic homogeneity by phosphocellulose, deae, and gel chromatography. its monomer mr by sodium dodecyl sulfate-polyacrylamide gel electrophoresis is 25 kda, ...	1988	3248721
cytosine methylation as an effector of right-handed to left-handed dna structural transitions.	cytosine methylation has energetic and structural influences on left-handed z-dna formation in supercoiled plasmids. the restriction and modification enzymes from haemophilus haemolyticus (hhai and m.hhai) provide a system to locate and analyze small segments of z-dna in large supercoiled plasmids. an approach is outlined that uses m.hhai as an in vivo conformational probe for the detection of unusual dna structures in a living cell. also, characteristic features of the m.hhai gene and protein a ...	1988	3266857
nongonococcal urethritis: diagnosis and management.		1987	3295152
[contribution of immunology to the early diagnosis of insulin-dependent diabetes].		2012	3302475
a randomized phase iii trial of cisplatinum, methotrexate, cisplatinum + methotrexate, and cisplatinum + 5-fluoro-uracil in end-stage head and neck cancer.	in a previous phase iii trial of chemotherapy for patients with end-stage squamous cell carcinoma of the head and neck we have shown that bleomycin shortened the survival period, compared with untreated controls. the survival of patients treated with cisplatinum and bleomycin did not differ significantly from untreated patients, but cisplatinum significantly prolonged survival. a further similar trial is reported here, the four treatment arms were methotrexate alone, cisplatinum alone, cisplatin ...	2012	3303823
endocrinology of breast cancer.	oestrogen predominance over progesterone may cause hyperproliferation of mammary epithelium and thus promote breast carcinogenesis. in patients with a hormone-dependent tumour, oestrogens may also accelerate cancer growth. conversely, they may inhibit tumour growth in patients with an oestrogen receptor-negative carcinoma which has grown in an oestrogen-poor environment. progesterone opposes oestrogen-induced epithelial proliferation and causes cellular differentiation with decreased mitosis, th ...	2012	3309571
ventricular assist devices. a bridge to cardiac transplantation.		2012	3314702
kinetic implications in the analytical use of enzymes.		2012	3318549
a guideline to local anesthetic allergy testing.	patients with a history of adverse reactions to a local anesthetic may often be incorrectly labeled as "allergic." determining if a patient is allergic to a local anesthetic is essential in the selection of appropriate pain control techniques. local anesthetic allergy testing may be performed safely and with reasonable accuracy by a knowledgeable practitioner. this paper presents guidelines for an allergy testing method.	2012	3318567
proposal for determining supportive care only status.		2011	3347915
changes in the incidence of fracture of the upper end of the humerus during a 30-year period. a study of 2125 fractures.	the incidence of fracture of the upper end of the humerus by age group and sex was studied for a 32-year period from 1950 to 1982. the following numbers of humeral fractures occurred: 1950-1954, 411 fractures; 1961-1964, 552 fractures; 1971-1973, 639 fractures; and 1981-1982, 523 fractures. there was a progressive increase in the age-related incidence in older persons, especially in women. there was a higher incidence of fractures classified as severe in the 1980s compared with the 1950s.	2012	3370872
crystal structure of enolase indicates that enolase and pyruvate kinase evolved from a common ancestor.	enolase or 2-phospho-d-glycerate hydrolase catalyses the dehydration of 2-phosphoglycerate to phosphoenolpyruvate, which in turn is converted by pyruvate kinase to pyruvate. we describe here the crystallographic determination of the structure of yeast enolase at high resolution (2.25 a) and an analysis of the structural homology between enolase, pyruvate kinase and triose phosphate isomerase. each of the two subunits of enolase forms two distinctive domains. the larger domain (residues 143-420) ...	1988	3374614
simultaneous cleft lip and palate repair: an experimental study in beagles.	this study was designed to test the hypothesis that simultaneous lip and palate repair results in more severe craniofacial growth aberrations than lip repair or palate repair performed separately. seventy-six purebred beagles were divided into five groups. two of these groups were controls (unoperated and unrepaired animals); the three remaining groups were experimental (in one group only the lip was repaired, in another only the palate was repaired, and in the last the lip and palate were repai ...	1988	3380923
assessment of small and large fiber function in long-term type 1 (insulin-dependent) diabetic patients with and without painful neuropathy.	twelve neural function tests (thermal discrimination thresholds, pain perception thresholds to heat and cold stimuli, vibration perception thresholds, and motor and sensory nerve conduction velocities) were assessed in the lower and upper extremities of 60 long-term type 1 diabetic patients. thirty patients were asymptomatic (group 1) and 30 patients had painful neuropathy (group 2), predominantly originating in the distal lower limbs (group 2a; n = 20) or in the distal upper limbs (group 2b; n ...	2012	3405615
criteria for a proof of migration routes of immature parasites inside hosts exemplified by studies of strongyloides ratti in the rat.	the first rigorous proof applicable to the migration pathway of an infective juvenile macroparasite inside its host is presented. third-stage larvae of a homogonic strain of strongyloides ratti applied in exact doses of less than 20 to the skin of the flank of young rats were recovered 16-40 h later in the naso-frontal part of the head. the peak proportion of the dose (po) recovered between 20 and 25 h in this site had a mean value of 0.316 +/- 0.021 in 48 animals. in 40 other rats infected simu ...	1988	3405640
folk images of health and menstrual patterns among newfoundland outport women.		2012	3417577
portosystemic shunting in portal hypertension: evaluation with portal scintigraphy with transrectally administered i-123 imp.	portosystemic shunting was evaluated with rectal administration of iodine-123 iodoamphetamine (imp) in seven patients without liver disease and 53 patients with liver cirrhosis. imp (2-3 mci [74-111 mbq]) was administered to the rectum through a catheter. images of the chest and abdomen were obtained for up to 60 minutes with a scintillation camera interfaced with a computer. in all patients, images of the liver and/or lungs were observed within 5-10 minutes and became clear with time. in patien ...	2012	3420249
experimental evaluation of the mitroflow pericardial heart valve prosthesis. part ii. pathologic examination.	the results of the morphologic and histopathologic examination of 37 bovine pericardial heart valve prostheses that were retrieved after experimental implantation in chacma baboons for periods of one to twelve months are presented in this study. the implanted prostheses consisted of 33 mitroflow valves, size 21 mm, that belonged to four different groups according to the method of preparation of the pericardium (process i to iv) and 4 commercially available ionescu-shiley valves, size 19 mm. all ...	1988	3421507
right-sided staphylococcus aureus endocarditis in intravenous drug abusers: two-week combination therapy.	to determine the efficacy of short-course combination regimens for selected cases of staphylococcus aureus endocarditis in intravenous drug abusers.	1988	3421575
lidcombe hospital--stroke unit audit.		2012	3435294
rlsq: t1, t2, and rho calculations, combining ratios and least squares.	a method is proposed for calculating images of spin density rho and relaxation times t1, t2 from mr imaging sequences with the following characteristics: it avoids nonlinear iterative techniques and is consequently sufficiently fast to allow calculation of rho, t1, and t2 on a pixel by pixel basis routinely; it uses all available data simultaneously in an approximately optimal fashion. the method is applied to the combined se + ir sequence but can be used for other acquisition schemes as well.	2012	3437812
surface abnormalities and conduit characteristics as a cause of blood trauma in artificial internal organs. the interaction of fluid-dynamic, physiochemical and cell biological reactions in thrombus formation.		2012	3439734
gilles de la tourette's syndrome and attention deficit disorder with hyperactivity. evidence against a genetic relationship.	results of a family study of gilles de la tourette's syndrome (ts) suggest that ts and attention deficit disorder (add) with hyperactivity are genetically separate disorders transmitted independently in families at risk. although the rate of ts among the relatives of the two proband groups was virtually the same (10.3% vs 11.1%), the rate of add among the relatives of probands with ts and add with hyperactivity was approximately eight times higher than the rate of add among the relatives of the ...	2012	3465279
distribution of noradrenaline in the brain of the teleost gasterosteus aculeatus l.: an immunohistochemical analysis.	the distribution of noradrenergic neurons in the brain of the three-spined stickleback was demonstrated with the indirect peroxidase-antiperoxidase (pap) immunohistochemical method with antibodies against a noradrenaline-bovine serum albumin conjugate. noradrenergic neuronal somata were exclusively located in the isthmal area of the brain stem and in the lower medulla. noradrenergic varicose axons innervate the reticular formation, motor nuclei, and interpeduncular nucleus of the brain stem, the ...	1986	3540043
cloning, sequencing, in vivo promoter mapping, and expression in escherichia coli of the gene for the hhai methyltransferase.	a 1476-base pair dna fragment from haemophilus haemolyticus containing the hhai methyltransferase gene was isolated from a cell library and cloned into pbr322. the nucleotide sequence of this fragment was determined. the structural gene is 981 nucleotides in length coding for a protein of 327 amino acids (mr 37,000). the translational start signal (atg) is preceded by the putative ribosome-binding site (taag). recombinant plasmids containing the 1476-basepair fragment are completely methylated w ...	1987	3549710
murine t-cell reactivity to cloned mycobacterium leprae antigens.		1986	3553803
identification of the mutagenic quinoxaline isomers from fried ground beef.	two mutagens isolated from fried-beef patties were compared to a series of synthetic structural isomers of 2-aminodimethylimidazo[4,5-f]quinoxaline (meiqx) and 2-aminotrimethylimidao[4,5-f]quinoxaline (dimeiqx). comparison by nmr spectrometry and hplc coelution showed that one beef mutagen (molecular weight of 213) was identical to the 8-meiqx isomer not the 7-me isomer. another quinoxaline beef mutagen, having 3 methyl groups (molecular weight of 227), had an nmr spectrum different from the 5,8 ...	1987	3553914
when can you leave africa?		2013	3573053
bupivacaine disposition in mother, fetus, and neonate after spinal anesthesia for cesarean section.	uptake of bupivacaine from the subarachnoid space and its placental transfer were measured in six patients undergoing elective cesarean section. maternal plasma levels (59 +/- 32 ng/ml) were only about 5% of those found in a comparable previous study of epidural anesthesia. mean plasma umbilical venous bupivacaine levels (20.2 +/- 21 ng/ml) were 7% of those found after epidural anesthesia. mean umbilical venous/maternal venous bupivacaine ratios were 0.34 +/- 0.12 and mean umbilical arterial/umb ...	2013	3578847