Publications

phylogenetic analysis of the spirochetes.	the 16s rrna sequences were determined for species of spirochaeta, treponema, borrelia, leptospira, leptonema, and serpula, using a modified sanger method of direct rna sequencing. analysis of aligned 16s rrna sequences indicated that the spirochetes form a coherent taxon composed of six major clusters or groups. the first group, termed the treponemes, was divided into two subgroups. the first treponeme subgroup consisted of treponema pallidum, treponema phagedenis, treponema denticola, a thermo ...	1991	1917844
enigmatic dual symbiosis in the excretory organ of nautilus macromphalus (cephalopoda: nautiloidea).	symbiosis is an important driving force in metazoan evolution and the study of ancient lineages can provide an insight into the influence of symbiotic associations on morphological and physiological adaptations. in the 'living fossil' nautilus, bacterial associations are found in the highly specialized pericardial appendage. this organ is responsible for most of the excretory processes (ultrafiltration, reabsorption and secretion) and secretes an acidic ammonia-rich excretory fluid. in this stud ...	2007	17311780
phylogenetic diversity and temporal variation in the spirochaeta populations from two mediterranean microbial mats.	spirochetes are among the bacterial groups often observed in hydrogen-sulfide-rich layers of coastal microbial mats. however, relatively few spirochetes from these microbial mats have been described and characterized. we used 16s rdna phylogenetic analysis to investigate the spirochetal diversity of microbial mats from two locations in the western mediterranean (ebro delta, spain, and camargue, france). samples from each location were monitored in the spring and winter over a period of 1 to 2 ye ...	2008	19204899
destruction of spirochete borrelia burgdorferi round-body propagules (rbs) by the antibiotic tigecycline.	persistence of tissue spirochetes of borrelia burgdorferi as helices and round bodies (rbs) explains many erythema-lyme disease symptoms. spirochete rbs (reproductive propagules also called coccoid bodies, globular bodies, spherical bodies, granules, cysts, l-forms, sphaeroplasts, or vesicles) are induced by environmental conditions unfavorable for growth. viable, they grow, move and reversibly convert into motile helices. reversible pleiomorphy was recorded in at least six spirochete genera (>1 ...	2009	19843691
complete genome sequence of the termite hindgut bacterium spirochaeta coccoides type strain (spn1(t)), reclassification in the genus sphaerochaeta as sphaerochaeta coccoides comb. nov. and emendations of the family spirochaetaceae and the genus sphaerochaeta.	spirochaeta coccoides dröge et al. 2006 is a member of the genus spirochaeta ehrenberg 1835, one of the oldest named genera within the bacteria. s. coccoides is an obligately anaerobic, gram-negative, non-motile, spherical bacterium that was isolated from the hindgut contents of the termite neotermes castaneus. the species is of interest because it may play an important role in the digestion of breakdown products from cellulose and hemicellulose in the termite gut. here we provide a taxonomic re ...	2012	22768363
conservation of the host-interacting proteins tp0750 and pallilysin among treponemes and restriction of proteolytic capacity to treponema pallidum.	the spirochete treponema pallidum subsp. pallidum is the causative agent of syphilis, a chronic, sexually transmitted infection characterized by multiple symptomatic and asymptomatic stages. although several other species in the genus are able to cause or contribute to disease, t. pallidum differs in that it is able to rapidly disseminate via the bloodstream to tissue sites distant from the site of initial infection. it is also the only treponema species able to cross both the blood-brain and pl ...	2015	26283341