Publications

phylogenetic comparison of retron elements among the myxobacteria: evidence for vertical inheritance.	twenty-eight myxobacterial strains, representing members from all three subgroups, were screened for the presence of retron elements, which are novel prokaryotic retroelements encoding reverse transcriptase. the presence of retrons was determined by assaying strains for a small satellite dna produced by reverse transcription called multicopy, single-stranded dna (msdna). an msdna-producing retron appeared to be absent from only one of the strains surveyed. dna hybridization experiments revealed ...	1995	7798147
characterization and description of anaeromyxobacter dehalogenans gen. nov., sp. nov., an aryl-halorespiring facultative anaerobic myxobacterium.	five strains were isolated which form a physiologically and phylogenetically coherent group of chlororespiring microorganisms and represent the first taxon in the myxobacteria capable of anaerobic growth. the strains were enriched and isolated from various soils and sediments based on their ability to grow using acetate as an electron donor and 2-chlorophenol (2-cph) as an electron acceptor. they are slender gram-negative rods with a bright red pigmentation that exhibit gliding motility and form ...	2002	11823233
a reassignment of (-)-mycothiazole and the isolation of a related diol.	a reinvestigation of the thiazole constituents from cacospongia mycofijiensis, collected in vanuatu, yielded known mycothiazole (3) plus a new derivative, mycothiazole-4,19-diol (6). the e stereochemistry at delta14,15 of 3 has been revised to z and the structural features of 6 are elucidated. these compounds, which presumably arise by the action of a polyketide-nonribosomal peptide synthetase (pks/nrps) hybrid, possess cytotoxic properties that need further exploration.	2006	16441088
the biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from streptomyces flavoviridis atcc 21892.	the biosynthetic gene cluster for the glycopeptide-derived antitumor antibiotic zorbamycin (zbm) was cloned by screening a cosmid library of streptomyces flavoviridis atcc 21892. sequence analysis revealed 40 orfs belonging to the zbm biosynthetic gene cluster. however, only 23 and 22 orfs showed striking similarities to the biosynthetic gene clusters for the bleomycins (blms) and tallysomycins (tlms), respectively; the remaining orfs do not show significant homology to orfs from the related blm ...	2009	19081934
the biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from streptomyces flavoviridis atcc 21892.	the biosynthetic gene cluster for the glycopeptide-derived antitumor antibiotic zorbamycin (zbm) was cloned by screening a cosmid library of streptomyces flavoviridis atcc 21892. sequence analysis revealed 40 orfs belonging to the zbm biosynthetic gene cluster. however, only 23 and 22 orfs showed striking similarities to the biosynthetic gene clusters for the bleomycins (blms) and tallysomycins (tlms), respectively; the remaining orfs do not show significant homology to orfs from the related blm ...	2009	19081934
fatty acid-related phylogeny of myxobacteria as an approach to discover polyunsaturated omega-3/6 fatty acids.	in an analysis of 47 aerobic myxobacterial strains, representing 19 genera in suborders cystobacterineae, nannocystineae, sorangiineae, and a novel isolate, "aetherobacter" sbsr008, an enormously diverse array of fatty acids (fas) was found. the distribution of straight-chain fatty acids (scfas) and branched-chain fatty acids (bcfas) supports the reported clustering of strains in the phylogenetic tree based on 16s rrna genes. this finding additionally allows the prediction and assignment of the ...	2011	21317327
nostophycin biosynthesis is directed by a hybrid polyketide synthase-nonribosomal peptide synthetase in the toxic cyanobacterium nostoc sp. strain 152.	cyanobacteria are a rich source of natural products with interesting pharmaceutical properties. here, we report the identification, sequencing, annotation, and biochemical analysis of the nostophycin (npn) biosynthetic gene cluster. the npn gene cluster spans 45.1 kb and consists of three open reading frames encoding a polyketide synthase, a mixed polyketide nonribosomal peptide synthetase, and a nonribosomal peptide synthetase. the genetic architecture and catalytic domain organization of the p ...	2011	21948844
function of the loading module in cori and of the o-methyltransferase corh in vinyl carbamate biosynthesis of the antibiotic corallopyronin a.	corallopyronin a is a promising in vivo active antibiotic, currently undergoing preclinical evaluation. this myxobacterial compound interferes with a newly identified drug target site, i.e., the switch region of the bacterial dna-dependent rna-polymerase (rnap). since this target site differs from that of known rnap inhibitors such as the rifamycins, corallopyronin a shows no cross-resistance with other antibacterial agents. corallopyronin a is a polyketide synthase- and nonribosomal peptide syn ...	2014	24277032