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gene therapy vectors based on adeno-associated virus type 1.the complete sequence of adeno-associated virus type 1 (aav-1) was defined. its genome of 4,718 nucleotides demonstrates high homology with those of other aav serotypes, including aav-6, which appears to have arisen from homologous recombination between aav-1 and aav-2. analysis of sera from nonhuman and human primates for neutralizing antibodies (nab) against aav-1 and aav-2 revealed the following. (i) nab to aav-1 are more common than nab to aav-2 in nonhuman primates, while the reverse is tru ...199910196295
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