Publications

mr lymphography with iron oxide compound ami-227: studies in ferrets with filariasis.	the purpose of this study was to assess the mr lymphographic potential of ami-227 to reduce the signal intensity of hyperplastic inflammatory lymph nodes by using ferrets with filariasis as the animal model. both interstitial and iv modes of administration were studied.	1992	1529857
lymphatic imaging in experimental filariasis using magnetic resonance.	to evaluate acquired lymphatic abnormalities caused by filariasis, the authors examined the peripheral lymphatic system in normal ferrets and those chronically infected with brugia malayi using magnetic resonance imaging (mri). the findings were compared with previously obtained lymphangioscintigraphic (las) images in ferrets both with and without experimental filariasis.	1992	1601619
vascular abnormalities in experimental and human lymphatic filariasis.	whereas clinical descriptions of grotesque lymphedema and standard light microscopy in human filariasis have elucidated the natural progression of this disease, the link between the nematode and vascular abnormalities including elephantiasis remains poorly understood. accordingly, we examined the nature and distribution of lymphatic and blood vascular derangements in a variety of tissues and organs from 37 ferrets acutely and chronically infected with brugia malayi and in 15 patients with wucher ...	1991	1791728
injection of microfilariae induces resistance to brugia malayi infection in ferrets and accelerates development of lymphostatic disease.	ferrets injected intravenously with living microfilariae or cutaneously with microfilariae followed by intravenous injection developed partial resistance to a challenge infection as measured by recovery of adult filariae from lymphatics. following a challenge infection, the ferrets injected with microfilariae developed lymphatic pathology characteristic of a chronic infection or that observed following multiple infections. there was disruption of lymphatic drainage of the infected limb and lymph ...	1990	2320382
lymphatic filariasis. brugia malayi infection in the ferret (mustela putorius furo).		1989	2757121
whole body lymphangioscintigraphy in ferrets chronically infected with brugia malayi.	whole body lymphangioscintigraphy was performed after intradermal injection of 99mtechnetium human serum albumin or antimony colloid in the distal hindlimbs and forelimbs of ferrets chronically infected with brugia malayi. the findings were compared with control ferrets and those with surgical interruption of the iliac lymphatics. while only one infected ferret manifested chronic hindlimb lymphedema, all exhibited delayed transport of radioisotope from the hindpaw with obstruction in the groin, ...	1988	3236904
enhanced inflammation to brugia malayi microfilariae in ferrets infected with trichinella spiralis.		1987	3437363
peripheral lymphedema in ferrets infected with brugia malayi.	this study examines the production and persistence of peripheral lymphedema in ferrets experimentally infected with brugia malayi. in 14 of 18 ferrets inoculated 2 or more times with infective larvae, lymphedema developed in the inoculated paw or paw and lower leg. in 5 of these ferrets lymphedema had persisted for 8 to 18 months at the time of necropsy. lymphedema rarely was observed following a single inoculation of larvae or in microfilaremic ferrets. the results suggest that the ferret may b ...	1987	3605495
antibody and cellular immune responses to microfilarial antigens in ferrets experimentally infected with brugia malayi.	eleven of 15 ferrets experimentally infected with brugia malayi became amicrofilaremic after a brief patency; only four ferrets remained patent after 6 months of infection and two of these ferrets developed a high, persistent microfilaremia. blastogenic responses of peripheral blood lymphocytes to antigens of microfilariae (mf), assayed in vitro, demonstrated an antigen sensitivity at prepatent, patent and postpatent periods of infection. lymphocytes from ferrets with high microfilaremia had ele ...	1986	3751232
lymphangiography in ferrets infected with brugia malayi.		1985	3835408
brugia malayi: intravenous injection of microfilariae in ferrets as an experimental method for occult filariasis.	microfilaremia, immune responses, and pathology were compared in ferrets infected with 100 third-stage larvae of brugia malayi (subperiodic strain) or injected intravenously with 10(6) microfilariae. ferrets (mustela putorius furo) inoculated with third-stage larvae typically became patent during the third month after infection, with a mean patency of 123 +/- 25 (se) days. ferrets injected intravenously with microfilariae exhibited a relatively constant microfilaremia for 3-4 weeks and usually c ...	1985	4029349
pathology of experimental infection with brugia malayi in ferrets: comparison with occult filariasis in man.	ferrets experimentally infected with brugia malayi (subperiodic strain) developed eosinophilia at patency and usually became amicrofilaremic. ferrets necropsied within 3 months after becoming amicrofilaremic had granulomas and focal reactions to degenerating microfilariae in their livers, lungs and lymph nodes essentially identical to those of tropical eosinophilia. four of 7 ferrets that received multiple inoculations of larvae, developed edema of the inoculated paw and leg after becoming amicr ...	1984	6152118
the histology and ultrastructure of the meyers-kouwenaar body in ferrets infected with brugia malayi.	a study was made of the meyers-kouwenaar (mk) body in the livers of experimentally infected ferrets. meyers-kouwenaar bodies, the carcasses of microfilariae (mff) covered by deposits of splendore-hoeppli (sh) material, were found in small abscesses of eosinophils and in granulomas. the sh deposits varied from an eosinophilic, hyaline fringe around intact mff to multilayered deposits surrounding an unrecognizable granular remnant. in abscesses, peroxidase activity was intense in sh deposits and t ...	1984	6507726
efficacy of the avermectins against filarial parasites: a short review.	the avermectins are macrocyclic lactones produced by streptomyces avermitilis. one of them has been chemically modified and given the non-proprietary name ivermectin. the compounds have shown efficacy against various stages of filarial parasites. with respect to pre-adult stages in the mammalian host, activity has been observed against dirofilaria immitis in ferrets and dogs, and dipetalonema viteae and litomosoides carinii in jirds (meriones); but activity has not been observed against the deve ...	1982	7051527
the ferret (mustela putorius furo) as an experimental host for brugia malayi and brugia pahangi.	ferrets inoculated subcutaneously with 150--200 infective larvae of brugia malayi (subperiodic strain) usually developed patent infection during the 3rd month post inoculation. microfilaremia was transient, and most animals became amicrofilaremic after the 6th month of infection. ferrets developed a persistent eosinophilia at the time of patency. at necropsy, 5--8 months post infection, adult worms were recovered principally from lymphatic vessels and recovery ranged from 0.5--13% of the inocula ...	1982	7102908
resistance and disease in brugia malayi infection of ferrets following prior infection, injection of attenuated infective larvae and injections of larval extracts.	a partial resistance expressed by a 53% to 78% reduction in lymphatic filariae from a challenge infection was induced in ferrets (mustela putorius furo) by a prior infection and by injection of radiation attenuated infective larvae (l3) but not by injections of lyophilized microfilariae (mf) or l3. equivalent acquired resistance was demonstrated with and without overt filarial disease. a prior infection resulted in peripheral lymphoedema in approximately one-third of the amicrofilaraemic resista ...	1994	7808763