Publications

callithrix penicillata: a feasible experimental model for dengue virus infection.	although the murine models have the feasibility to reproduce some signs of dengue virus (denv) infection, the use of isogenic hosts with polarized immune response patterns does not reproduce the particularities of human disease. our goal was to investigate the kinetics of peripheral blood biomarkers in immunocompetent callithrix penicillata non-human primates subcutaneously infected with denv-3. the viral load of infected animals was determinated by quantitative real time pcr. measurements of de ...	2015	24361035
antibody-enhanced dengue disease generates a marked cns inflammatory response in the black-tufted marmoset callithrix penicillata.	severe dengue disease is often associated with long-term neurological impairments, but it is unclear what mechanisms are associated with neurological sequelae. previously, we demonstrated antibody-enhanced dengue disease (ade) dengue in an immunocompetent mouse model with a dengue virus 2 (denv2) antibody injection followed by denv3 virus infection. here we migrated this ade model to callithrix penicillata. to mimic human multiple infections of endemic zones where abundant vectors and multiple s ...	2016	26303046
hierarchical cluster analysis of three-dimensional reconstructions of unbiased sampled microglia shows not continuous morphological changes from stage 1 to 2 after multiple dengue infections in callithrix penicillata.	it is known that microglial morphology and function are related, but few studies have explored the subtleties of microglial morphological changes in response to specific pathogens. in the present report we quantitated microglia morphological changes in a monkey model of dengue disease with virus cns invasion. to mimic multiple infections that usually occur in endemic areas, where higher dengue infection incidence and abundant mosquito vectors carrying different serotypes coexist, subjects receiv ...	2016	27047345
microglial morphology across distantly related species: phylogenetic, environmental and age influences on microglia reactivity and surveillance states.	microglial immunosurveillance of the brain parenchyma to detect local perturbations in homeostasis, in all species, results in the adoption of a spectrum of morphological changes that reflect functional adaptations. here, we review the contribution of these changes in microglia morphology in distantly related species, in homeostatic and non-homeostatic conditions, with three principal goals (1): to review the phylogenetic influences on the morphological diversity of microglia during homeostasis ...	2021	34220831