Publications

inoculation of ferrets with ten third-stage larvae of dracunculus insignis.	infection with dracunculus insignis was established in 7 of 10 ferrets experimentally inoculated intraperitoneally with 10 third-stage larvae (l3's). worm recovery and infection rate were comparable to animals inoculated with 50 l3's. this study demonstrates that once infective larvae traverse the gut and pass into the peritoneal cavity, very few larvae are required to establish infection.	1991	1833521
dracunculus insignis in ferrets: comparison of inoculation routes.	three routes of inoculation were compared to determine the best method to infect ferrets with dracunculus insignis. the traditional method of administering infected cyclops containing l3s through gavage was compared to intraperitoneal (i.p.) and subcutaneous (s.c.) inoculation of l3s. ten of 18 (56%) gavaged ferrets became infected after receiving copepods containing approximately 100 l3s each; 44 adult worms were recovered from these 10 animals. twenty-one of 28 (75%) animals inoculated with 50 ...	1990	2137166
distribution, behavior, and course of patency of dracunculus insignis in experimentally infected ferrets.	from 106 ferrets experimentally infected with dracunculus insignis, 273 female worms and 42 male worms were recovered. the percentage of female worms that mated, the location of all worms, and the rate of emergence of gravid females were recorded. of 174 mature female worms recovered, only 11% had emerged before necropsy. eighty-one percent of the male worms and 87% of all unmated (immature) females were found on the trunk of the animal or on the skin overlying it. gravid female worms were found ...	1990	2143224
chemoprophylactic drug trials for treatment of dracunculiasis using the dracunculus insignis-ferret model.	groups of ferrets inoculated with dracunculus insignis were treated with various anthelminthic compounds to evaluate the potential use of drugs in controlling the human parasite d. medinensis. the three primary compounds tested were diethylcarbamazine (dec), albendazole (albz), and invermectin (iver); they were administered in dosages of 60 mg/kg, 10 mg/kg, and 1 mg/kg, respectively. groups of animals received treatment either once at 60 days after inoculation, once at 60 and 90 days, or for 3 d ...	1990	2143770
dracunculus insignis: experimental infection in the ferret, mustela putorius furo.	the laboratory study of dracunculiasis has suffered from the lack of a suitable, readily available animal model. we have been able to experimentally infect ferrets. mustela putorius furo, with the north american dracunculid, dracunculus insignis. ferrets were inoculated with 75 to 100 infective larvae and were necropsied 90 to 240 days later. guinea worms were recovered from 10 (56%) of 18 ferrets. a total of 44 worms were recovered, for an average of 4.4 worms per infected ferret. gravid female ...	1988	2973492
possible role of fish as transport hosts for dracunculus spp. larvae.	to inform dracunculus medinensis (guinea worm) eradication efforts, we evaluated the role of fish as transport hosts for dracunculus worms. ferrets fed fish that had ingested infected copepods became infected, highlighting the importance of recommendations to cook fish, bury entrails, and prevent dogs from consuming raw fish and entrails.	2017	28820381