Publications

diversity of microbes associated with the marine sponge, haliclona simulans, isolated from irish waters and identification of polyketide synthase genes from the sponge metagenome.	samples of the sponge haliclona simulans were collected from irish waters and subjected to a culture-independent analysis to determine the microbial, polyketide synthase (pks) and non-ribosomal peptide synthase (nrps) diversity. 16s rrna gene libraries were prepared from total sponge, bacterial enriched sponge and seawater samples. eight phyla from the bacteria were detected in the sponge by phylogenetic analyses of the 16s rrna gene libraries. the most abundant phylum in the total sponge librar ...	2008	18430018
isolation and analysis of bacteria with antimicrobial activities from the marine sponge haliclona simulans collected from irish waters.	samples of the marine sponge haliclona simulans were collected from irish coastal waters, and bacteria were isolated from these samples. phylogenetic analyses of the cultured isolates showed that four different bacterial phyla were represented; bacteriodetes, actinobacteria, proteobacteria, and firmicutes. the sponge bacterial isolates were assayed for the production of antimicrobial substances, and biological activities against gram-positive and gram-negative bacteria and fungi were demonstrate ...	2009	18953608
phylogenetic diversity and antimicrobial activities of fungi associated with haliclona simulans isolated from irish coastal waters.	the diversity and antimicrobial activities of 80 fungi isolated from haliclona simulans were assessed using different fungal media containing either agar or gellum gum. in total, 19 different genotypes were detected. these fungal isolates could be classified as members of the agaricomycotina, mucoromycotina, saccharomycotina, and pezizomycotina, although the majority of the isolates were associated with the latter class. some of these fungal isolates showed antimicrobial inhibition of escherichi ...	2009	19083060
endoglucanase activities and growth of marine-derived fungi isolated from the sponge haliclona simulans.	the conversion of cheap cellulosic biomass to more easily fermentable sugars requires the use of costly cellulases. we have isolated a series of marine sponge-derived fungi and screened these for cellulolytic activity to determine the potential of this unique environmental niche as a source of novel cellulase activities.	2010	19840179
tetracycline resistance-encoding plasmid from bacillus sp. strain #24, isolated from the marine sponge haliclona simulans.	knowledge of the nature of resistance determinants in natural habitats is fundamental to increasing our understanding of the development of antibiotic resistance in clinical settings. here we provide the first report of a tetracycline resistance-encoding plasmid, pbhs24, from a marine sponge-associated bacterium, bacillus sp. strain #24, isolated from haliclona simulans.	2010	21057017
diversity and antimicrobial activity of pseudovibrio spp. from irish marine sponges.	to evaluate the diversity and antimicrobial activity present among pseudovibrio spp. isolated from marine sponges.	2011	21435124
diversity and bioactive potential of endospore-forming bacteria cultured from the marine sponge haliclona simulans.	despite the frequent isolation of endospore-formers from marine sponges, little is known about the diversity and characterization of individual isolates. the main aims of this study were to isolate and characterize the spore-forming bacteria from the marine sponge haliclona simulans and to examine their potential as a source for bioactive compounds.	2012	21985154
isolation identification and biochemical characterization of a novel halo-tolerant lipase from the metagenome of the marine sponge haliclona simulans.	lipases (ec 3.1.1.3) catalyze the hydrolysis of triacyl glycerol to glycerol and are involved in the synthesis of both short chain and long chain acylglycerols. they are widely used industrially in various applications, such as baking, laundry detergents and as biocatalysts in alternative energy strategies. marine ecosystems are known to represent a large reservoir of biodiversity with respect to industrially useful enzymes. however the vast majority of microorganisms within these ecosystems are ...	2012	22657530
subtilomycin: a new lantibiotic from bacillus subtilis strain mma7 isolated from the marine sponge haliclona simulans.	bacteriocins are attracting increased attention as an alternative to classic antibiotics in the fight against infectious disease and multidrug resistant pathogens. bacillus subtilis strain mma7 isolated from the marine sponge haliclona simulans displays a broad spectrum antimicrobial activity, which includes gram-positive and gram-negative pathogens, as well as several pathogenic candida species. this activity is in part associated with a newly identified lantibiotic, herein named as subtilomyci ...	2013	23736764
metabolomic profiling and genomic study of a marine sponge-associated streptomyces sp.	metabolomics and genomics are two complementary platforms for analyzing an organism as they provide information on the phenotype and genotype, respectively. these two techniques were applied in the dereplication and identification of bioactive compounds from a streptomyces sp. (sm8) isolated from the sponge haliclona simulans from irish waters. streptomyces strain sm8 extracts showed antibacterial and antifungal activity. nmr analysis of the active fractions proved that hydroxylated saturated fa ...	2014	24893324
a novel erythromycin resistance plasmid from bacillus sp. strain hs24, isolated from the marine sponge haliclona simulans.	a better understanding of the origin and natural reservoirs of resistance determinants is fundamental to efficiently tackle antibiotic resistance. this paper reports the identification of a novel 5.8 kb erythromycin resistance plasmid, from bacillus sp. hs24 isolated from the marine sponge haliclona simulans. pbhs24b has a mosaic structure and carries the erythromycin resistance gene erm(t). this is the first report of an erythromycin resistance plasmid from a sponge associated bacteria and of t ...	2014	25548909