Publications

genomic analysis of highly virulent georgia 2007/1 isolate of african swine fever virus.	african swine fever is widespread in africa but has occasionally been introduced into other continents. in june 2007, african swine fever was isolated in the caucasus region of the republic of georgia and subsequently in neighboring countries (armenia, azerbaijan, and 9 states of the russian federation). previous data for sequencing of 3 genes indicated that the georgia 2007/1 isolate is closely related to isolates of genotype ii, which has been identified in mozambique, madagascar, and zambia. ...	2011	21470447
african swine fever virus georgia isolate harboring deletions of mgf360 and mgf505 genes is attenuated in swine and confers protection against challenge with virulent parental virus.	african swine fever virus (asfv) is the etiological agent of a contagious and often lethal disease of domestic pigs that has significant economic consequences for the swine industry. the control of african swine fever (asf) has been hampered by the unavailability of vaccines. experimental vaccines have been developed using genetically modified live attenuated asfvs where viral genes involved in virus virulence were removed from the genome. multigene family 360 (mgf360) and mgf505 represent a gro ...	2015	25810553
african swine fever virus georgia isolate harboring deletions of 9gl and mgf360/505 genes is highly attenuated in swine but does not confer protection against parental virus challenge.	african swine fever virus (asfv) produces a contagious disease of domestic pigs that results in severe economic consequences to the swine industry. control of the disease has been hampered by the unavailability of vaccines. we recently reported the development of two experimental vaccine strains (asfv-g-δ9gl and asfv-g-δmgf) based on the attenuation of the highly virulent and epidemiologically relevant georgia2007 isolate. deletion of the 9gl gene or six genes of the mgf360/505 group produced tw ...	2016	27182007
genetically edited pigs lacking cd163 show no resistance following infection with the african swine fever virus isolate, georgia 2007/1.	african swine fever is a highly contagious, often fatal disease of swine for which there is no vaccine or other curative treatment. the macrophage marker, cd163, is a putative receptor for african swine fever virus (asfv). pigs possessing a complete knockout of cd163 on macrophages were inoculated with georgia 2007/1, a genotype 2 isolate. knockout and wild type pen mates became infected and showed no differences in clinical signs, mortality, pathology or viremia. there was also no difference fo ...	2017	27898335