Publications

implementation of an in vitro fertilization program.	the establishment of an in vitro fertilization program is described. organization of the physical laboratory, media formulation, and preliminary mouse embryo culture are discussed. parameters of patient eligibility, ovarian stimulation, and laparoscopy are also defined. at the conclusion of phase i, 17 patients were induced; 10 went to laparoscopy, and at least one four-cell embryo was returned to 7, resulting in one continuing pregnancy.	1984	6242163
use of biological assay systems to assess the relative carcinogenic hazards of disinfection by-products.	other workers have clearly shown that most, if not all, drinking water in the u.s. contains chemicals that possess mutagenic and/or carcinogenic activity by using bacterial and in vitro methods. in the present work, increased numbers of tumors were observed with samples of organic material isolated from 5 u.s. cities administered as tumor initiators in mouse skin initiation/promotion studies. only in one case was the result significantly different from control. in studies designed to test whethe ...	1982	7151763
serologic evidence of infection with ehrlichia spp. in wild rodents (muridae: sigmodontinae) in the united states.	rodent (muridae: sigmodontinae) blood and sera collected from 14 states were tested for seroreactivity to a cultured isolate of the human granulocytic ehrlichiosis (hge) agent by using an indirect immunofluorescence assay. of the 1,240 samples tested, 136 (11%) were found to be reactive at titers of > or = 32. rodents with hge agent-specific antibodies were found in new york (23% of 491 samples; geometric mean endpoint titer [gmt] = 441), connecticut (11% of 100 samples; gmt = 481), california ( ...	1998	9508298
community mental health--the mouse that roared or marketing a public agency.	as the market place becomes increasingly competitive, marketing has been more aggressively undertaken by private business, and more recently, by proprietary and not for profit hospitals and other human service organizations. this article describes the efforts of an urban, publicly supported, multi-provider mental health system to develop an assertive, positive marketing stance. following a brief historical development, the authors describe the current public relations campaign and some of the sp ...	1983	10266216
using quicktime virtual reality objects in computer-assisted instruction of gross anatomy: yorick--the vr skull.	quicktime virtual reality (qtvr) is a software technology that creates, on a normal computer screen, the illusion of holding and turning a three-dimensional object. qtvr is a practical photo-realistic virtual reality technology that is easily implemented on any current personal computer or via the internet with no special hardware requirements. because of its ability to present dynamic photo-quality images, we reasoned that qtvr can provide a more realistic presentation of anatomic structure tha ...	2000	10873221
identification of a deletion in the mismatch repair gene, msh2, using mouse-human cell hybrids monosomal for chromosome 2.	hereditary non-polyposis colorectal cancer is characterized by mutations in one of the dna mismatch repair genes, primarily mlh1, msh2, or msh6. we report here the identification of a genomic deletion of approximately 11.4 kb encompassing the first two exons of the msh2 gene in two generations of an ohio family. by southern blot analysis, using a cdna probe spanning the first seven exons of msh2, an alteration in each of three different enzyme digests (including a unique 13-kb band on hindiii di ...	2003	12694232
reduced paneth cell alpha-defensins in ileal crohn's disease.	the pathogenesis of crohn's disease (cd), an idiopathic inflammatory bowel disease, is attributed, in part, to intestinal bacteria that may initiate and perpetuate mucosal inflammation in genetically susceptible individuals. paneth cells (pc) are the major source of antimicrobial peptides in the small intestine, including human alpha-defensins hd5 and hd6. we tested the hypothesis that reduced expression of pc alpha-defensins compromises mucosal host defenses and predisposes patients to cd of th ...	2005	16330776
plasminogen activator inhibitor type-1 (pai-1) polymorphism 4g/5g is associated with prostate cancer among men with a positive family history.	variation in the expression of plasminogen activator inhibitor type-1 (pai-1) is associated with many human diseases, including several types of cancer. in particular, tumor cell overexpression of pai-1 has been found to inhibit prostate cancer tumor growth, angiogenesis, and metastasis in mouse models. normal host cell expression of pai-1 is influenced by the 4g/5g insertion/deletion polymorphism in the promoter region of the pai-1 gene. to evaluate the effect of pai-1 expression on cancer deve ...	2007	17044080