Publications

malignant tumors during the first 2 decades of life in the offspring of atomic bomb survivors.	the risk of cancer (incidence) prior to age 20 years has been determined for children born to atomic bomb survivors and to a suitable comparison group. tumor ascertainment was through death certificates and the tumor registries maintained in hiroshima and nagasaki. the rationale for the study stemmed from the evidence that a significant proportion of such childhood tumors as retinoblastoma and wilms tumor arise on the basis of a mutant gene inherited from one parent plus a second somatic cell mu ...	1990	2160192
[the causative agent from a patient with spotted fever group rickettsiosis in japan on awaji island, hyogo].	misaka strain was isolated as the causative agent from a patient with spotted fever group rickettsiosis in japan by using nude mice on awaji island, hyogo in september 1988. the nude mice infected with the isolate showed weakness and splenomegaly and died in two or three weeks after the infection. the cyclophosphamide-treated mice infected with the isolate died between four and seven days after the infection. the infected normal mice recovered and acquired immunity. the infected adult male guine ...	1990	2205668
risk estimation based on germ-cell mutations in animals.	the set of mouse germ cell mutation rate results following spermatogonial exposure to high dose rate irradiation have been presented as the most relevant experimental results upon which to extrapolate the expected genetic risk of offspring of the survivors of the hiroshima and nagasaki atomic bombings. results include mutation rates to recessive specific-locus, dominant cataract, protein-charge, and enzyme-activity alleles. the mutability as determined by the various genetic end points differed: ...	1989	2698841
implications of the hiroshima-nagasaki genetic studies for the estimation of the human "doubling dose" of radiation.	since 1946 a continuous effort to evaluate the potential genetic effects of the atomic bombs has been sustained. observations on children born in hiroshima and nagasaki include sex ratio, congenital malformations, stillbirths, survival of liveborn infants, chromosomal abnormalities (sex chromosomal abnormalities and balanced chromosomal rearrangements), mutations altering protein structure or activity, and physical growth and development. there are no statistically significant differences betwee ...	1989	2698842
on the lack of genetic damage in hiroshima and nagasaki. or is the mouse a good model for man?		1984	6724925
paralytic toxicity in the ribbon worm cephalothrix species (nemertea) in hiroshima bay, hiroshima prefecture, japan and the isolation of tetrodotoxin as a main component of its toxins.	paralytic toxicity of ribbon worms ("himomushi" in japanese), identified as undescribed species of the genus cephalothrix, found on the surface of the shells of cultured oysters in hiroshima bay, hiroshima prefecture was examined between april 1998 and december 2001. the toxicity study showed that all of specimens were found to contain toxins with strong paralytic action in mice; the highest toxicity (as tetrodotoxin, ttx) was 25,590 mouse units (mu) per gram for whole body throughout the monito ...	2003	12782074