Publications

epidemiology of malaria in malaysia.	malaria is a major public health problem in malaysia, particularly in peninsular malaysia and the state of sabah. an eradication program started in the states of sabah and sarawak in 1961 initially was remarkably successful. a similar but staged program was started in peninsular malaysia in 1967 and was also quite successful. however, a marked upsurge in incidence in sabah in 1975-1978 showed that malaria is still a major hazard. the disease leads to great economic losses in terms of the product ...	1982	6755616
plasmodium knowlesi malaria in humans is widely distributed and potentially life threatening.	until recently, plasmodium knowlesi malaria in humans was misdiagnosed as plasmodium malariae malaria. the objectives of the present study were to determine the geographic distribution of p. knowlesi malaria in the human population in malaysia and to investigate 4 suspected fatal cases.	2008	18171245
the emerging of the fifth malaria parasite (plasmodium knowlesi): a public health concern?	after examining the most recent scientific evidences, which assessed the role of some malaria plasmodia that have monkeys as natural reservoirs, the authors focus their attention on plasmodium knowlesi. the infective foci attributable to this last plasmodium species have been identified during the last decade in malaysia, in particular in the states of sarawak and sabah (malaysian borneo), and in the pahang region (peninsular malaysia). the significant relevance of molecular biology assays (poly ...	2010	20835518
plasmodium knowlesi: from malaysia, a novel health care threat.	epidemic foci of plasmodium knowlesi malaria have been identified during the past ten years in malaysia, in particular in the states of sarawak and sabah (malaysia borneo), and in the pahang region (peninsular malaysia). based on a review of the available recent international literature, the authors underline the importance of molecular biology examinations, polymerase chain reactions (pcr), performed with primers specific for p. knowlesi, since the current microscopic examination (haemoscope) m ...	2012	22475654
deaths due to plasmodium knowlesi malaria in sabah, malaysia: association with reporting as plasmodium malariae and delayed parenteral artesunate.	the simian parasite plasmodium knowlesi is recognized as a common cause of severe and fatal human malaria in sabah, malaysia, but is morphologically indistinguishable from and still commonly reported as plasmodium malariae, despite the paucity of this species in sabah. since december 2008 sabah department of health has recommended intravenous artesunate and referral to a general hospital for all severe malaria cases of any species. this paper reviews all malaria deaths in sabah subsequent to the ...	2012	22905799
epidemiology of plasmodium knowlesi malaria in north-east sabah, malaysia: family clusters and wide age distribution.	the simian parasite plasmodium knowlesi is a common cause of human malaria in malaysian borneo, with a particularly high incidence in kudat, sabah. little is known however about the epidemiology in this substantially deforested region.	2012	23216947
increased detection of plasmodium knowlesi in sandakan division, sabah as revealed by plasmonex™.	plasmodium knowlesi is a simian malaria parasite that is widespread in humans in malaysian borneo. however, little is known about the incidence and distribution of this parasite in the sandakan division, malaysian borneo. therefore, the aim of the present epidemiological study was to investigate the incidence and distribution of p. knowlesi as well as other plasmodium species in this division based on a most recent developed hexaplex pcr system (plasmonex™).	2013	23902626
changing epidemiology of malaria in sabah, malaysia: increasing incidence of plasmodium knowlesi.	while malaysia has had great success in controlling plasmodium falciparum and plasmodium vivax, notifications of plasmodium malariae and the microscopically near-identical plasmodium knowlesi increased substantially over the past decade. however, whether this represents microscopic misdiagnosis or increased recognition of p. knowlesi has remained uncertain.	2014	25272973
molecular detection of human plasmodium species in sabah using plasmonex™ multiplex pcr and hydrolysis probes real-time pcr.	malaria is a vector borne-parasitic disease transmitted through the bite of the infective female anopheles mosquitoes. five plasmodium species have been recognized by world health organization (who) as the causative agents of human malaria. generally, microscopic examination is the gold standard for routine malaria diagnosis. however, molecular pcr assays in many cases have shown improvement on the sensitivity and specificity over microscopic or other immunochromatographic assays.	2015	25651852
transfusion-transmitted severe plasmodium knowlesi malaria in a splenectomized patient with beta-thalassaemia major in sabah, malaysia: a case report.	transfusion-transmitted malaria (ttm) is a well-recognized risk of receiving blood transfusions, and has occurred with plasmodium falciparum, plasmodium vivax, plasmodium ovale, and plasmodium malariae. the simian parasite plasmodium knowlesi is also known to be transmissible through inoculation of infected blood, and this species is now the most common cause of malaria in malaysia with a high rate of severity and fatal cases reported. no confirmed case of accidental transfusion-transmitted p. k ...	2016	27405869