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high prevalence of antibodies to human herpesvirus 8 in relatives of patients with classic kaposi's sarcoma from sardinia.a survey for antibodies to a recombinant small viral capsid antigen (svca) of human herpesvirus type 8 (hhv-8) was conducted in sardinia, one of the world's highest incidence areas for classic kaposi's sarcoma (ks). prevalence of antibodies to hhv-8 svca was greatest in patients with ks (95%), followed by family members (39%) and a sardinian control population age- and sex-matched to the relatives (11%). within families, prevalence of antibodies was about equal among spouses, children, and sibli ...19989607855
human herpesvirus 8 seroprevalence in sardinia. 19989665151
seroprevalence of kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 in several regions of italy.to study the seroprevalence of kaposi's sarcoma-associated herpesvirus/human herpesvirus type 8 (kshv/hhv-8) in 779 italian blood donors.199810195244
prevalence of antibodies to human herpesvirus 8 in children from sardinia and croatia. 200011073147
human herpes virus-8 infection among pregnant women and their children: results from the sardinia-iddm study 2. 200111267990
hhv-8 prevalence, immunosuppression and kaposi's sarcoma in south italy.the identification of hhv-8 has opened the way for numerous epidemiological studies aimed at determining both the prevalence of hhv-8 in various sub-groups of the population (affected or not by ks) and at identifying possible cofactors necessary for the development of ks. we set up a study to evaluate the prevalence of hhv-8 in the south of italy in ks cases, hospital patients and blood donors and to verify the role of immunosuppression in ks. in ks patients the prevalence of lytic and latent an ...200111295117
direct correlation between human herpesvirus-8 seroprevalence and classic kaposi's sarcoma incidence in northern sardinia.the human herpesvirus-8 (hhv-8) has been associated with the development of kaposi's sarcoma. a high incidence of classic kaposi's sarcoma has been described in sardinia, an island west of italy's mainland. different seroepidemiological analyses have reported that prevalence of hhv-8 infection varies worldwide: a high hhv-8 seroprevalence has been shown in italy. the present survey was carried out to evaluate the correlation between hhv-8 infection and classic kaposi's sarcoma incidence in north ...200111536246
reduced seroprevalence of kaposi's sarcoma-associated herpesvirus (kshv), human herpesvirus 8 (hhv8), related to suppression of anopheles density in italy.in two formerly malarious parts of italy, age-related seroprevalence rates of kaposi's sarcoma-associated herpesvirus [human herpesvirus 8 (kshv/hhv8)] were determined from local blood donors and correlated with periods of vector control during anti-malaria campaigns. in veneto, decreased kshv/hhv8 seroprevalence in the 1951-1955 birth cohort coincides with the peak of ddt house-spraying. in sardinia, where larviciding augmented indoor ddt-spraying, a significant drop of kshv/hhv8 seroprevalence ...200314651663
high rate of human herpesvirus-8 seroprevalence in thalassemic patients in italy.the potential risk of acquiring infection by the novel human herpesvirus-8 (hhv-8) through blood derivatives is still debated.200415072763
susceptibility to human herpesvirus-8 infection in a healthy population from sardinia is not directly correlated with the expression of hla-dr alleles. 200415270911
a common genetic variant in fcgr3a-v158f and risk of kaposi sarcoma herpesvirus infection and classic kaposi sarcoma.associations of fcgr3a among men with hiv/acquired immunodeficiency syndrome suggest that host responses affect the pathogenesis of kaposi sarcoma herpesvirus (kshv) infection and risk of acquired immunodeficiency syndrome-associated kaposi sarcoma. using dna from two hiv seronegative case-control populations in italy, we examined whether the functional fcgr3a-v158f variant was associated with risk of kshv infection or classic kaposi sarcoma (cks). in population i, we examined fcgr3a variants an ...200515767342
infection with human herpesvirus type 8 and kaposi's sarcoma in sardinia.a cross-sectional study was conducted in the provinces of sassari (northern sardinia, covered by a population-based cancer registry), and of cagliari (southern sardinia) to estimate the prevalence of infection with human herpesvirus type 8 (hhv8) and the incidence of classic kaposi's sarcoma (ks) among hhv8-infected individuals.200616501902
environmental factors influence the rate of human herpesvirus type 8 infection in a population with high incidence of classic kaposi sarcoma.high prevalence of human herpesvirus type 8 (hhv-8) infection has been reported on the island of sardinia. among emigrants from sardinia, rates of hhv-8 infection are lower than they are in sardinia and are similar to those observed in the local population. thus, environmental factors seem to play a relevant role in affecting the prevalence of hhv-8 infection.200616511749
kaposi sarcoma: a continuing conundrum.kaposi sarcoma (ks) remains a challenge. its classic or mediterranean form tends to be benign. in transplant recipients it may be less so. as part of the aids pandemic, of which it was an original defining component, it may be life-threatening. it is due to human herpesvirus-8, which is necessary but not sufficient to produce the disease. ks has a low prevalence in the general population of the united states and united kingdom, with an intermediate rate in italy and greece, and a high one in par ...200818638627
distribution of 'promoter' sandflies associated with incidence of classic kaposi's sarcoma.the patchy geographical distributions of classic kaposi's sarcoma (ks) and human herpesvirus type 8 (hhv-8), better known as kaposi's sarcoma-associated herpesvirus (kshv) remain unexplained. it has been proposed that certain species of bloodsucking insects ('promoter arthropods') promote the reactivation of hhv-8/kshv and facilitate both hhv-8/kshv transmission and ks development. this hypothesis was tested by sampling the presence and density of human-biting diptera with cdc light traps in two ...200919712152
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