Publications

entomological and epidemiological investigations of malaria transmission in relation to population movements in forest areas of north-west thailand.	transmission of forest-related malaria was observed entomologically and epidemiologically for 2 transmission seasons in 1990 and 1991 in 5 villages of mae sariang district, mae hong son province, north-west thailand. the entomological study included collections of mosquitos and determination of infection rate by using enzyme-linked immunosorbent assay in the residential villages and the farm huts. the epidemiological study included fortnightly visits to 30% of the households to interview and rec ...	1998	9740259
desbutyl-benflumetol, a novel antimalarial compound: in vitro activity in fresh isolates of plasmodium falciparum from thailand.	desbutyl-benflumetol (dbb) is a novel antimalarial compound closely related to benflumetol (lumefantrine), of which it is a putative metabolite. the in vitro response of plasmodium falciparum to dbb was studied in mae hong son and mae sot, in northwest thailand, in 1997 and 1998. in total, 155 fresh isolates were successfully tested using the world health organization standard in vitro microtest system (mark ii). the mean 50% effective concentration (ec(50)) and 90% effective concentration of db ...	2001	11408230
randomized trial of artesunate and mefloquine in comparison with quinine sulfate to treat p. falciparum malaria pregnant women.	to compare the effectiveness and safety of quinine sulfate and artesunate with mefloquine for treating second trimester pregnancy in women who suffered from plasmodium falciparum malaria. the prospective study was done in srisangwal hospital, mae hong son, thailand. sixty, second to third trimester pregnant patients with p. falciparum infection, were recruited at random. they received either quinine sulfate 10 mg/kg/day for at least 7 days, 29 women (group i), or oral artesunate 2 mg/kg as the f ...	2001	11800303
infectious reservoir of plasmodium infection in mae hong son province, north-west thailand.	it was unknown whether the main reservoir of plasmodium falciparum and plasmodium vivax, which infects mosquitoes in thailand, was (a) in people feeling sufficiently ill with malaria to come to a clinic or (b) in people who had remained in their home villages with some fever symptoms or with none.	2004	15385050
comparative study of the in vitro sensitivity of plasmodium falciparum to artemisinin in two border areas of thailand.	artesunate was introduced in thailand in 1995 for the treatment of falciparum malaria in areas of multidrug resistance, where it is used in combination with mefloquine. the studies were conducted between may and august 1999, 2000 and 2001 in the provinces mae hong son and tak (mae sot district) in northwestern thailand, both on the border to myanmar. the province of mae hong son is still largely unaffected by multidrug resistance and infections with plasmodium falciparum are treated with mefloqu ...	2004	15683041
declining mefloquine sensitivity of plasmodium falciparum along the thai-myanmar border.	mefloquine sensitivity of plasmodium falciparum along the thai-myanmar border, both in vitro and in vivo, following different first-line treatments for uncomplicated falciparum malaria patients in these areas during the period 1997--2003 were studied. standard in vitro micro tests and in vivo efficacy according to world health organization methodologies were performed. p. falciparum isolates along the thai-myanmar border with in vitro sensitivity to mefloquine have had up to a ten-fold decrease ...	2004	15689066
changes in malaria vector densities over a twenty-three year period in mae hong son province, northern thailand.	mae hong son province in northwestern thailand has a long history of malaria. during the last two decades the province has had one of the highest malaria incidences of all provinces in thailand. data were analyzed to determine whether the vector populations were stable or increasing during the last two decades and to determine the seasonal prevalence of the main vectors, and whether or not they were related to the malaria transmission peak, in the wet season. we compiled and analyzed accumulated ...	2004	15691130
susceptibility of two karyotypic forms of anopheles aconitus (diptera: culicidae) to plasmodium falciparum and p. vivax.	four laboratory-raised colonies of two karyotypic forms of anopheles aconitus, i.e., form b (chiang mai and phet buri strains) and c (chiang mai and mae hong son strains), were experimentally infected with plasmodium falciparum and p. vivax using an artificial membrane feeding technique and dissected eight and 12 days after feeding for oocyst and sporozoite rates, respectively. the results revealed that an. aconitus form b and c were susceptible to p. falciparum and p. vivax, i.e., form b (chian ...	2005	16553323