Publications

sequence analyses of the p24 gene of borna disease virus in naturally infected horse, donkey and sheep.	by reverse transcriptase/pcr amplification and subsequent sequence determination of the p24 gene, the relatedness of borna disease virus (bdv) in various naturally infected animal species was determined. these results are indicative of a common ancestral virus pool and a remarkably low species barrier of bdv. comparison of 11 sequences to that of tissue culture adapted virus revealed that the homology among all isolates was at least 96.2% at the nucleotide level, and 97% at the amino acid level. ...	1994	7856315
detection of borna disease virus rna in naturally infected animals by a nested polymerase chain reaction.	borna disease virus in naturally infected horses, a donkey and sheep was detected for the first time by amplification of viral rna using pcr. in contrast to a control group of healthy horses, brain tissue was positive by this assay in all animals with neurological symptoms. the use of a second round of pcr with nested primers following southern hybridization confirmed the specificity and increased the sensitivity of the test. comparison with conventional methods recommends this technique for mon ...	1994	8188810
presence of cd4+ and cd8+ t cells and expression of mhc class i and mhc class ii antigen in horses with borna disease virus-induced encephalitis.	tissues from 9 horses and 1 donkey suffering from natural borna disease were investigated immunomorphologically. lymphocytic inflammatory reactions and increased expressions of mhc class i and class ii antigen were found in the brain as well as in the trigeminal and olfactory system. perivascular inflammatory infiltrates were dominated by cd4+ t cells, whereas the majority of cd8+ t cells were disseminated intraparenchymally. no evidence of inflammation was found in the retina. borna disease vir ...	1995	8520721
[distribution of borna disease virus in naturally infected animals with clinical disease].	borna disease (bd) is a naturally occurring enzootic encephalomyelitis of horses and sheep. the aetiological agent, borna disease virus (bdv) is an unclassified, neurotropic, negative stranded rna virus. the study aimed at providing further information on bd of naturally infected animals. samples obtained from 20 animals (18 horses, 1 donkey, 1 sheep) were investigated by a series of virological and molecular biological tests. the highly sensitive reverse transcription-polymerase chain reaction ...	1996	8694747
evidence for natural borna disease virus infection in healthy domestic animals in three areas of western china.	borna disease virus (bdv) is a non-cytolytic, neurotropic rna virus that can infect many vertebrate species, including humans. to date, bdv infection has been reported in a range of animal species across a broad global geographic distribution. however, a systematic epidemiological survey of bdv infection in domesticated animals in china has yet to be performed. in current study, bdv rna and antibodies in 2353 blood samples from apparently healthy animals of eight species (horse, donkey, dog, pig ...	2014	24573218
host and viral traits predict zoonotic spillover from mammals.	the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ...	2017	28636590