Publications

treatment of multiple sclerosis with various interferons: the cons.	while alpha and beta interferons are relatively nontoxic human gene products and have been used in the treatment of multiple sclerosis, the results of a pilot study in 18 patients treated with recombinant gamma interferon indicate that this form is unsuitable for therapy in ms.	1988	3133576
pathology of stranded beluga whales (delphinapterus leucas) from the st. lawrence estuary, québec, canada.	from june 1983 to may 1986, thirteen carcasses of stranded beluga whales from a polluted area of the st. lawrence river, canada were necropsied. high performance liquid chromatography was performed on the brains of three other animals to determine concentrations of benzo a pyrene (bap). two juvenile animals had severe multisystemic lesions one of which, a severe necrotizing dermatitis, was associated with a herpesvirus-like particle. four adults had five varieties of tumours. an adult had a syst ...	1988	3134469
peliosis hepatis in a patient with marasmus.	peliosis hepatitis is a rare disorder previously seen in tuberculosis and malignant disorders and now seen with anabolic steroid use or after renal transplantation. we report the first case of peliosis hepatis in a patient with marasmus and no previously reported predisposing condition. of interest, the peliosis hepatis resolved rapidly (over 2-3 wk) as determined by computed tomography scan and the patient presented with a cholestatic enzyme pattern that resolved with development of the lesion.	2011	3135227
[testicular histology in azoospermia--diagnostic value of plasma fsh, lh, testosterone and prolactin values].		2010	3136043
segregation analysis of juvenile myoclonic epilepsy.	we examined the inheritance of juvenile myoclonic epilepsy (jme). we looked at both the trait of "epilepsy" and the trait of "epilepsy-plus-eeg abnormalities," since eeg abnormalities are frequently found in the clinically unaffected sibs of jme patients. we tested several modes of inheritance including the fully penetrant recessive and several two-locus models. we could reject all models tested (fully penetrant single-locus and two-locus models) when abnormal eegs were classified as "unaffected ...	2010	3136050
hiv seroprevalence in migrant and seasonal farmworkers--north carolina, 1987.		1988	3136308
[postoperative debasement of the host-defense system and wound healing in elderly patients, and nutritional support as a therapeutic implication].	plasma opsonic activity and several kinds of plasma protein levels in each pre- and post-operative days were compared between older 25 cases (70 years or older) and 31 younger cases (59 years or younger) which both underwent elective abdominal surgery. the activity to opsonize e. coli 075 as a host-defense capacity was reduced on postoperative days 1,3 and returned gradually in either young or elderly. but opsonic activity levels in elderly patients in each postoperative days were significantly ...	1988	3136311
determining the prevalence of epilepsy in the semi-urban population of nakuru, kenya, comparing two independent methods not apparently used before in epilepsy studies.	due to meagre resources in terms of trained medical personnel and financial support and the absence of accurate population-based data in most parts of the developing world, there is an urgent need to develop new epidemiological study designs that are simple, accurate and easy to use. key informant methodology and random cluster sample survey methods were used independently (a) to determine the prevalence of epilepsy and (b) to compare the efficiency, cost effectiveness and feasibility of the two ...	2011	3136404
platelet-activating factor and the cardiovascular system: involvement in cardiac anaphylaxis.		1988	3136455
"in situ" modulation of murine neuroblastoma growth and biochemical differentiation by the adrenergic nervous system and nerve growth factor.		2011	3136459
[blood glucose in the acute phase of myocardial infarction treated with nitroglycerin or heparin].		2011	3136514
alternating non-cross-resistant chemotherapy for metastatic hormone-independent breast cancer.	a phase ii clinical trial was designed to apply the treatment strategy of alternating non-cross-resistant chemotherapy regimens to patients with metastatic estrogen-receptor negative or hormone-refractory breast cancer. twenty-six patients received adriamycin and cyclophosphamide alternating at 3-week intervals with the combination of vinblastine, mitomycin-c, and 5-fluorouracil (5-fu). toxicity was moderately severe. two patients developed grade 2 and three developed grade 1 stomatitis. a singl ...	2011	3136644
value of cerebrospinal fluid analysis in the differential diagnosis of meningitis: a study in 710 patients with suspected central nervous system infection.	a prospective study to determine the value of cerebrospinal fluid analysis in the differential diagnosis of meningitis was performed in 710 consecutively observed patients, both children and adults, who underwent lumbar puncture due to suspected central nervous system infection. diagnoses included acute or presumed bacterial meningitis (n = 79), acute or presumed viral meningoencephalitis (n = 218), acute unclassified meningitis (n = 6), other infections of the central nervous system (n = 37), n ...	2011	3137038
expectancy effects on respiration during lactate infusion.	the effect of lactate infusion on pco2 and respiration rate was studied in two differently instructed groups of healthy volunteers in a double-blind, placebo-controlled, cross-over study. both groups showed a significant decrease in alveolar pco2 after lactate but not after placebo. this was accompanied by an increase in respiration rate in those subjects who had expected to become anxious and by a decrease in respiration rate in those who had expected to experience pleasant excitement.	2011	3137634
posttranslational modifications of the ia-associated invariant protein p41 after gene transfer.	biochemical analysis of a rat fibroblast cell clone, transfected with the murine ia associated invariant chain gene, demonstrates the expression of a family of proteins. this indicates that all members of the invariant protein family are derived from the same gene. the proteins p41, ii, p27, p25, and p10, synthesized in the transfectant cell line, are identical with the invariant proteins previously shown to associate noncovalently with ia antigens. these proteins are identified by immunoprecipi ...	1988	3137970
gastroenteritis due to vibrio cholerae el tor ogawa.		1988	3138473
a case of homocystinuria.		2011	3138571
disruption of development on triatominae bugs by action of juvenile hormone analogues.		2011	3138739
[hemodynamic effect of certain vasodilators on the major and lesser circulation].		2011	3140174
asnr presidential address, 1988.		2011	3140646
[methohexital/alfentanil-thiopental/alfentanil for total intravenous anesthesia for direct laryngoscopy with 100% o2 jet ventilation].	for the direct laryngoscopy and microscopic examination of the larynx with exploratory excision and pulpectomy using low frequency jet-ventilation with 100% oxygen we used total intravenous anaesthesia with a strong acting opioid and a barbiturate. because the achievement of sufficient reflexes and a high degree of vigilance postoperatively are to be aimed, methohexitone (m) and thiopentone (t) were investigated in the regard of the suppression of vigilance in the postoperative period. 40 patien ...	2011	3140687
characteristics of polymerized pyridoxylated hemoglobin.	polymerization of sfh-p currently provides the only approach that leads to a hemoglobin solution that approximates the o2 carrying capacity of whole blood and can be infused without altering the cop of plasma. it appears to have an adequate o2 loading and unloading characteristic and a greatly improved intravascular half-life. in addition, stable shelf-life at 4 degrees c of greater than five months, makes it a prime candidate for future pre-clinical and clinical investigations.	1988	3140917
intracellular injection of ca2+ chelator does not affect spike repolarization of cat spinal motoneurons.	both intra- and extracellular injections of tetraethylammonium (tea) prolonged the spike repolarization of motoneurons in the spinal cord of cats under pentabarbitone anaesthesia, but did not depress the afterhyperpolarization (ahp). intracellular injections of egta and the fast-acting ca2+ chelator, bapta, greatly depressed the ahp, but the spike shape remained unchanged. extracellular applications of cd2+ had similar effects. these observations suggest that a ca2+-dependent k+ outward current ...	1988	3141006
[short-latency brain stem evoked potentials to acoustic stimulation in posttraumatic epilepsy].	as a result of a comprehensive analysis of posttraumatic epileptic patients the changes in brain stem acoustic evoked potentials are described.	2011	3142192
guidelines for the use of vitamins, trace elements, calcium, magnesium, and phosphorus in infants and children receiving total parenteral nutrition: report of the subcommittee on pediatric parenteral nutrient requirements from the committee on clinical practice issues of the american society for clinical nutrition.		2011	3142247
effect of cholecystectomy on common bile duct diameters: a longitudinal prospective ultrasonographic study.	the medium-term effect of cholecystectomy on common bile duct diameters (cbd) was investigated prospectively in 64 patients with gallstone disease examined by ultrasonography immediately before and 27 months to 39 months after the operation. in 32 patients with chronic cholecystitis and patent cystic ducts, cbd diameters increased slightly (median 4.6 mm pre- and 5.3 mm postoperatively; p less than 0.05). a group of 19 patients with acute cholecystitis or cystic duct occlusion showed a significa ...	2009	3142922
[the role of the nurse and her education between the past and the future. analysis of realities in calabria].		2011	3143127
restriction endonuclease analysis of brucella abortus.	the restriction endonuclease profiles of bacterial dna from brucella abortus isolates were evaluated. it was not possible to distinguish between vaccine strain 19 and virulent (biotype 1 and biotype 2) strains of b abortus. restriction endonuclease analysis is therefore not a suitable epidemiological tool in bovine brucellosis investigations. the genetic homogeneity of the brucella genus was reinforced by these findings.	1988	3143134
pseudo grey platelet syndrome--grey platelets due to degranulation in blood collected into edta.	we have studied a woman with a history of mild bruising and bleeding, with a normal platelet count and normal clotting factors, who had platelets that appeared grey when stained and viewed under the microscope. unlike the grey platelet syndrome, the abnormality was only evident when blood had been collected into edta and not when citrate or heparin was used as anticoagulant. this 'pseudo grey platelet syndrome' was associated with platelet dense body and alpha granule secretion with no aggregati ...	2011	3143601
current status of clinical islet transplantation.		2011	3143652
[hemolysin production by vibrio cholerae non-o1 and o1 el tor determined by biological and immunological activities].		1988	3143787
pseudoanaphylaxis: two case studies.		2011	3143943
epithelioid granulomatosis with initial and predominant manifestation in spleen. morphological and immunohistochemical analysis of six cases.	in six patients with systemic symptoms, four of which had lymphoplasmacytic infiltrates in the bone marrow splenectomy was performed because of suspected malignant lymphoma, with resolution of clinical symptoms. the spleen showed epithelioid granulomas, and neither splenic tissue nor clinical follow-up revealed evidence of malignant lymphoma. immunohistochemical analysis documented an identical phenotype in epithelioid and giant cells as well as in large numbers of cd4 + lymphocytes and s100 + i ...	2011	3144805
immunoglobulin administration into cerebral subarachnoid space in a child with hypogammaglobulinemia and aseptic meningoencephalitis.		2011	3144830
the critically ill surgical patient: nutritional considerations.	the nutritional care of the patient in the surgical intensive care unit is one of the most challenging in the field of nutritional support. each patient must be assessed individually and specific goals of nutritional support established. specialized nutritional solutions may be needed for the patient with significant renal, hepatic, or pulmonary disease, as well as patients in a chronic septic state. knowledge of the infectious and metabolic complications that frequently occur in this population ...	2007	3145109
crystals in calcified epiphyseal cartilage and cortical bone of the rat.	the size of hydroxyapatite (hap) crystals in calcified cartilage and cortical bone of the rat has been studied and compared with that of synthetic poorly crystalline hydroxyapatite (pcha). crystal size was determined by x-ray diffraction and selected-area dark field imaging, and their elemental compositions were determined by emission spectroscopy. the crystal size of cartilage, bone, and pcha were found to be between 120 and 170 a in length by 50 a in width as determined by both x-ray diffracti ...	1988	3145127
the effects of norplant-2 rods on clinical chemistry in singaporean acceptors after 1 year of use: haemostatic changes.	a longitudinal study of coagulation parameters was carried out on 100 singapore acceptors using the levonorgestrel subdermal implants norplant-2 rods for contraceptive purposes. at the end of 1 year of use, results from this on-going study indicates that these acceptors have an enhanced potential for hypercoagulation with a significant shortening of their prothrombin time and activated partial thromboplastin time. they also have an increased predisposition to thrombosis as evidenced by significa ...	1988	3145169
chemical modification of the antitumor antibiotic glidobactin.	a variety of glidobactin analogs modified at the fatty acid, l-threonine and nucleus moieties of the molecule were synthesized and their structure-activity relationships examined. the antitumor and antifungal activity was greatly influenced by modification of the fatty acid glidobactin, with the dodecanoyl and tetradecanoyl analogs exhibiting better antitumor activity than the parent antibiotics. replacement of the l-threonine with other amino acids greatly reduced the activity and reduction of ...	2011	3145257
[bloemendaal, the hague].		2011	3145626
[intravenous combination anesthesia using alfentanil in infants].	intravenous anesthesia is a method rarely used during infancy. only neuroleptanalgesia has a number of indications, especially in major surgery and for seriously ill children. there are several advantages of inhalation anesthesia in infancy: good control of anesthesia because of low fat-muscle mass, low functional residual capacity, relatively increased alveolar ventilation, and increased cardiac output. potential disadvantages of inhalation anesthesia in infancy are numerous: the necessity of h ...	2011	3145688
is vitellogenin an ancestor of apolipoprotein b-100 of human low-density lipoprotein and human lipoprotein lipase?	vitellogenin, an ancient animal protein, is the major yolk protein of eggs, where it is used as a food source during embryogenesis. here it is shown that vitellogenins, including those from the invertebrates caenorhabditis elegans and drosophila melanogaster, contain domains that are homologous with parts of apolipoprotein b-100 (apob-100) of human low-density lipoprotein and human lipoprotein lipase. as vitellogenins are likely to have been used by invertebrates during embryogenesis well before ...	1988	3145737
kinetic factors influencing the dissolution behavior of calcium oxalate renal stones: a constant composition study.	a constant composition method has been used to examine the dissolution kinetics of calcium oxalate renal stones over a wide range of undersaturation in vitro. demineralization experiments have been carried out with the concentrations of calcium and oxalate ions and ionic strength (hence the solution undersaturation) held constant by the potentiometrically controlled addition of medium electrolyte solution as diluent, triggered by a calcium ion electrode. kinetic data for renal stones have been c ...	2011	3145798
effects of excess vitamin a and canthaxanthin on salivary gland tumors.	the effects of feeding semipurified diets supplemented with excess retinyl palmitate (20,000 and 100,000 iu/kg), beta-carotene (250 mg/kg), and canthaxanthin (250 mg/kg) on 7,12-dimethylbenz[a]anthracene (dmba)-induced salivary gland tumors were studied in rats. none of the dietary supplements had a significant effect on tumor incidence. tumor weights, however, tended to be lower in rats fed the dietary supplements compared with the controls. the incidence of tumor-bearing rats with large tumors ...	1988	3146058
[a new sensitivity test for substances used as antiseptics or disinfectants. i. biological studies].	in this first article, the authors present a fast method of determining the bactericide and bacteriostatic power of the germs, based on the disparition of the succino-dehydrogenase activity of a bacterium, objectified by a neotetrazolium chloride reaction. this reaction allows a colorimetric qualitative and quantitative determination of the activity of a preparation and the duration of its contact with the bacteria. this method allows a study in electronic microscopy which will be published in a ...	1988	3146445
tumor necrosis factor and hiv p24 antigen levels in serum of hiv-infected populations.	tumor necrosis factor (tnf) and hiv p24 antigen levels were determined in the serum of intravenous drug abusers (ivdas), homosexuals, and patients with lymphadenopathy or acquired immune deficiency syndrome (aids). the mean tnf level in the serum of normal controls was 12 +/- 5 compared to 112 +/- 25 pg/ml in the serum of hiv-seronegative asymptomatic ivdas. this increase of tnf may be due to the variety of infections that these people are exposed to persistently. the mean tnf level in the serum ...	1988	3146635
characterization of a chimaeric plasminogen activator obtained by insertion of the second kringle structure of tissue-type plasminogen activator (amino acids 173 through 262) between residues asp130 and ser139 of urokinase-type plasminogen activator.	a chimaeric recombinant plasminogen activator (rscu-pa- k2) obtained by insertion of the second kringle (k2) of tissue-type plasminogen activator (t-pa) (amino acids 173-262) between residues asp130 and ser139 of single chain urokinase-type plasminogen activator (scu-pa) was purified from the conditioned medium of mouse myeloma cells transfected with the previously described plasmid pulb9137 (piérard et al., j. biol. chem. 262, 11771-11778, 1987). approximately 22 micrograms of purified protein ...	1988	3146822
[ultrahistochemical demonstration of blood group b substances on human erythrocytes with a lectin from salmo gairdneri rich].	from the roe of salmo gairdneri rich., a lectin was isolated which agglutinates specifically human erythrocytes of blood group b. for cytochemical labelling of the blood group substance b on the surface of human erythrocytes, an indirect approach was chosen. by means of a polyclonal antibody from the rabbit against the b-specific fish lectin, electronmicroscopic presentation was performed with protein a gold using a multistep method. for quantification gold labelling was partially followed by a ...	1988	3146853
cellular immunity after oral administration with v. cholerae.		1988	3147307
[pigmented neurofibrosarcoma in a patient with von recklinghausen's disease: clinical and ultrastructural studies].		2011	3147337
[characteristics of changes in cardiac output and blood gas composition in humans in modeling the effects of weightlessness].		2011	3147343
nad(p)h dehydrogenase (quinone) from sporotrichum pulverulentum.		2011	3147357
on the role of the dorsal noradrenergic bundle in learning and habituation to novelty.	in experiment 1, the performance of vehicle control rats and rats with 6-hydroxydopamine-induced lesions of the dorsal noradrenergic bundle (db) was examined in acquisition and extinction of bar pressing and in spontaneous and food-reinforced alternation in a t-shape maze. plasma corticosterone levels in basal conditions, after chronic food restriction, after transportation to a novel environment, and after sessions of either rewarded or nonrewarded bar pressing were assayed. db lesions produced ...	1988	3147459
the chlordiazepoxide/pentylenetetrazol discrimination: characterization of drug interactions and homeostatic responses to drug challenges.	rats were trained to discriminate chlordiazepoxide (cdp) from pentylenetetrazol (ptz) in a two-lever food motivated discrimination task. training drug doses were adjusted until subjects emitted approximately 50% of their responses on each of the two drug-appropriate levers during saline injection tests. tests that followed injection of cdp/ptz combinations illustrated a reciprocal antagonism between the two drugs. saline-injection tests that followed large dose injections of cdp revealed a perio ...	1988	3147473
nicotine tolerance: an analysis of the time course of its development and loss in the rat.	the time course of the development and loss of tolerance to nicotine was measured in female rats that were injected subcutaneously (sc), twice daily with 1.6 mg/kg nicotine. tolerance to nicotine-induced decreases in locomotor activity and body temperature were observed. tolerance to the effects of nicotine on both of these measures developed rapidly, with maximal changes occurring within 2-4 days after initiation of treatment. the binding of l-[3h]-nicotine was measured in six brain regions. ch ...	1988	3147478
[transperitoneal transport of methotrexate: in vitro studies].		1988	3147495
[the laboratorio nacional de referencia de mycobacteria y tuberculosis in the antituberculosis campaign in cuba].		1988	3147500
the venous blood-flow of the flexor aspect of the human forearm. clinical relevance to the distally-pedicled forearm flap.	in the distally-pedicled radial island flap a reverse venous flow was observed. in 20 cadaver extremities the veins of the lower arms were perfused and dissected and the island flaps elevated. the 3 venous systems are described here according to the number, site and shape of the valves and the venous flow from the flap is also discussed.	1988	3147536
the simavi-tanga project for self-help in health. an assessment of a comprehensive primary health care programme.	primary health care (phc) is the major strategy for achieving the goal of health for all. lessons are to be learnt from a variety of experiences. the simavi-tanga project for self-help in health is a comprehensive phc-project with a limited input of external financial and advisory assistance. the short term outcome in terms of effectiveness and efficiency does not differ essentially from comparable tanzanian projects with a higher degree of external input. the main limiting factors with regard t ...	1988	3147549
effect of glycosylation inhibitors on the binding of insulin and lectins and on hormonal imprinting in tetrahymena.	treatment of the unicellular tetrahymena with inhibitors of glycosylation (glucosamine or 2-fluoro-2-deoxy-d-glucose) leads, with a few exceptions, to enhancement of the binding of fitc-labelled insulin and lectins (con-a, helix, datura). the development of insulin-evoked imprinting (i.e., the enhancement of binding at subsequent contacts) is not prevented by the administration of glucosamine. meanwhile the administration of fluoroglucose results, on its own, in enhanced binding. this increased ...	2011	3147568
the impact of long-term lithium treatment on renal function and structure.	the effects of long-term lithium treatment on kidney function have been intensively studied. both retrospective and prospective functional studies have shown that prolonged lithium treatment has a profound influence on renal tubular function, and may result in reduced renal concentrating capacity and increased urine volumes. more important, long-term lithium administration at non-toxic serum levels has little demonstrable or no effect at all on glomerular function. prospective studies found no e ...	2011	3147581
the effect of hypophysectomy on inhibin production by adult rat ovaries: changes in ovarian inhibin gene expression and serum inhibin.	we have investigated the effect of hypophysectomy on adult rat ovarian inhibin alpha- and beta a-subunit mrna, serum inhibin, and circulating gonadotrophin levels. immediate declines in ovarian inhibin gene expression and serum inhibin were observed following hypophysectomy, with a nadir on day 4. however, inhibin synthesis determined by these parameters was still apparent at 16 days post-hypophysectomy. gonadotropin levels were suppressed following hypophysectomy and the fall in inhibin product ...	1988	3147584
adverse reaction of acetaminophen as an alternative analgesic in a.a.s. triad.	the syndrome of a.a.s. triad consisting of an intolerance to analgesics such as aspirin, bronchial asthma and nasal polyps, is every day more frequent. during the last years, the use of acetaminophen as an analgesic-antipyretic alternative in patients with a.a.s. triad has been imperative. however, there are already publications that show reversible bronchial obstruction symptoms similar to the ones produced by a.a.s., though of less intensity. a study was performed in 32 patients diagnosed of a ...	2011	3147588
the development of immunological relationship between mother and fetus under physiological and pathological conditions.	on the basis of results of our research and review of literature, the complex of immuno logical influences, operating during the development of the human fetus, were evaluated. it is obvious that during the early stages of pregnancy the conceptus is protected by non-specific mechanisms, i.e. hormonally (hcg, progesterone) and by certain properties of the trophoblast (barrier function, immunologically inert surface). specific immunological tolerance is formed by gradual penetration of trophoblast ...	1988	3147589
use of a microcomputer relational database in a long-term-care psychiatric facility.		2011	3147597
[physiopathologic justification of long-term oxygen therapy in chronic respiratory insufficiency].		2011	3147599
[ablation of atrio-ventricular conduction by fulguration of the his bundle. proposal for a simplified technic. apropos of 70 cases].	between 1982 and 1987, 70 patients (32 men, 38 women, aged from 45 to 93 years) underwent catheter ablation of his bundle and were followed up for more than 3 months. the disorders treated were atrial fibrillation, flutter of tachycardia (62 cases), junctional tachycardia (7 cases) and refractory atrial extrasystoles (1 case). the overall results were: early failure in 1 case, late death in 3 cases, persistent high degree av block in 53 cases (75 p. 100), 1st degree av block in 9 cases (12 p. 10 ...	2011	3147638
primate models for evaluation of aids vaccines.		1988	3147661
an electron microscope study of the development of the exocrine and endocrine pancreas with special reference to intercellular junctions.	intercellular junctions in pancreatic acinar, duct and endocrine cells were studied by thin section and freeze-fracture methods in developing rats and mice. undifferentiated cells were joined by the zonula occludens and isolated fragments of tight junctional strands. small gap junctions were either occasionally associated with tight junctional strands or appeared independent of them. during the morphological differentiation of acinar cells, strands of the zonula occludens developed to form a com ...	1988	3147689
isolation of the early phase of chylomicron formation in intestinal epithelial cells of rats.	lipid is first observed electron microscopically in the rough endoplasmic reticulum of intestinal epithelial cells during active lipid absorption. we have been able to isolate this subcellular fraction by using discontinuous sucrose gradients of 0.25/0.86/1.11 m sucrose. a preliminary low speed centrifugation of mucosal homogenate removed the heavier subcellular organelles. the resulting supernatant was centrifuged at 5.25 x 10(6) x g.min. the pellet from this centrifugation was placed on top of ...	1988	3147719
general practitioner referral rates.		2011	3147751
some thoughts about the evolution of pediatric endocrinology in the united states and illustrative selected advances.		2010	3148256
characterization of the priming effects of human granulocyte-macrophage colony-stimulating factor on human neutrophil leukotriene synthesis.	human granulocyte-macrophage colony-stimulating factor (gm-csf) is an in vitro and in vivo stimulator of human bone marrow myelomonocytic precursor cells and mature granulocyte and macrophage effector cells. we have compared the effect of gm-csf on the synthesis of 5-lipoxygenase products induced by the chemotactic peptide fmet-leu-phe and the calcium ionophore a23187 in human neutrophils. although gm-csf alone did not stimulate detectable synthesis of products of the 5-lipoxygenase pathway, pre ...	1988	3148964
base-sequence dependence of noncovalent complex formation and reactivity of benzo[a]pyrene diol epoxide with polynucleotides.	the base-sequence selectivity of the noncovalent binding of (+/-)-trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyr ene (bpde) to a series of synthetic polynucleotides in aqueous solutions (5 mm sodium cacodylate buffer, 20 mm nacl, ph 7.0, 22 degrees c) was investigated. the magnitude of a red-shifted absorbance at 353 nm, attributed to intercalative complex formation, was utilized to determine values of the association constant kic. intercalation in the alternating pyridine-pu ...	2011	3149504
pertussis vaccines in japan.		2010	3149848
pertussis vaccines in japan.		2010	3149848
therapeutic effect of dexamethasone in t-2 toxicosis.	t-2 toxin is a mycotoxin that induces toxemia characterized by numerous hematological and biochemical changes. we have previously shown that prostaglandin (pg) production in brain tissue is increased following t-2 toxin. the present study was designed in order to test the effect of dexamethasone on brain prostaglandins and survival of rats subjected to t-2 toxin. furthermore, the effect of bw 755c, a dual inhibitor of the cyclooxygenase and lipoxygenase pathways of arachidonate metabolism, on th ...	1987	3150046
cell-free assays and the mechanism of receptor-mediated endocytosis.		2011	3150882
health education for children in the control of schistosomiasis.	health education for children is an important measure in the control of schistosomiasis especially considering the characteristics of the disease during childhood, such as high prevalence, high percent of treatment resistance, high rates of egg elimination and high level of reinfection, as reported in studies conducted in endemic areas. all of these facts indicate that children play a role in the maintenance and transmission of schistosomiasis. historically in brazil, health education concerning ...	2011	3151105
[evaluation of two experimental models of end-to-side microvessel anastomosis in rats].		1988	3151320
vascular dysplasia of arteries in neurocristopathies: a lesson for neurofibromatosis.	in a 15-year-old girl suffering from congenital constipation, megacolon combined with a 'ranken neuroma' of the rectum and a short aganglionic segment of distal colon was observed. the specific vascular alterations in the region of the ranken neuroma (which has previously been described in cases of von recklinghausen neurofibromatosis) were studied, with an emphasis on immunohistochemical methods. the results suggest that the pericytes are the cells primarily involved in the distinctive alterati ...	2010	3152480
successful islet transplantation in bb rats without chronic immunosuppression.		1987	3152652
aspects of brazilian paediatric nephrology.	brazil is a large country with different population densities in its five geographical regions, each of which has severe but unevenly distributed socioeconomic problems which affect the health care system. this makes the accurate assessment of renal disease in the large paediatric population which comprises 40% of the total population especially difficult. this paper analyses the experience of one paediatric nephrology unit. urinary tract infection affecting 44% of the patients was the most comm ...	2011	3153022
diagnosis and treatment of iron overload in paediatric patients on chronic haemodialysis.	in this study the incidence and contributing factors of iron overload in paediatric patients treated with intermittent haemodialysis were evaluated. particular attention was given to the diagnostic value of serum ferritin in the assessment of body iron stores in patients with hepatocellular damage. the results of treatment of secondary haemosiderosis with desferrioxamine (dfo) are reported. serum ferritin levels were measured in 18 children and adolescents undergoing long-term haemodialysis; 8 o ...	2011	3153030
effects of growth hormone therapy and malnutrition on the growth of rats with renal failure.	we examined the effects of methionyl-human growth hormone (met-hgh) and malnutrition on the growth of 5/6 nephrectomized rats and sham-operated controls. one group of sham-operated rats (pfs) was pair-fed with a group of nephrectomized rats in renal failure (rf); another group of sham-operated rats was fed ad libitum (als), and a final group of rats with renal failure (rf-gh) was treated with 4 iu/day met-hgh. after 4 weeks, rf-gh rats gained 12.3 +/- 1.7 cm in length; this was more than the 10. ...	1988	3153055
the iridovirus frog virus 3: a model for trans-acting proteins.	the amphibian iridovirus, frog virus 3 (fv3), produces at least two trans-activating proteins that stimulate the expression of viral genes. one of these proteins induces transcription from the promoter of an immediate-early fv3 gene, whereas the other induces transcription from exogenously methylated dna. these proteins may serve as a model for both viral and cellular trans-acting factors.	1986	3153144
anti-idiotypic antibodies: a new generation of vaccines against infectious agents.	anti-idiotypic antibodies have been suggested recently as candidates for potential vaccines against numerous infectious organisms. these antibody-based vaccines might represent a new generation of vaccines for inducing protective immunity in susceptible hosts.	2010	3153167
how do bacteria attach to solid surfaces?		2010	3153184
[treatment of essential vesico-ureteral reflux in children: computer-assisted decision].		2010	3153193
[bilirubin and bile acids: 2 prognostic factors in biliary atresia].		2010	3153206
plasma and erythrocyte concentrations of mercaptopurine after oral administration in children.	plasma and erythrocyte concentrations of 6-mercaptopurine (6-mp) were determined by gas chromatography-mass spectrometry. eleven children (9 with acute lymphatic leukemia) were studied after oral intake of 6-mp doses ranging between 31 and 128 mg/m2 body surface area. the concentrations of 6-mp in plasma were found to vary considerably between patients even after dose normalization to 75 mg/m2. after dose normalization the mean peak plasma concentration was 0.68 microm (range 0.12-1.38) and the ...	2010	3153216
neuroblastoma--an overview of laboratory studies aimed at inducing tumor regression by initiation of differentiation or administration of antitumor drugs.	experimental laboratory investigations aimed at inducing tumor regression are reviewed critically. possible interference with tumor growth by induction of differentiation has stimulated studies employing cell lines in vitro and in vivo of murine and, more recently human origin. the diverse range of agents proving effective inducers has facilitated studies of morphological and biochemical differentiation. however, the precise molecular events involved are still unclear, and any therapeutic potent ...	1986	3153219
childhood cancer in siblings.	the medical records of 973 previously untreated patients diagnosed between january 1960 and december 31, 1978 with childhood cancer were reviewed. siblings in 13 families were diagnosed with cancer 9/12 to 15 years after the diagnosis of cancer in the index sibling. previously unreported association of acute lymphoblastic leukemia with hodgkin's disease, neuroblastoma with malignant hemangiopericytoma, non-hodgkin's lymphoma with malignant melanoma, wilms' tumor with non-hodgkin's lymphoma, hodg ...	2010	3153235
acute leukemia with extramedullary presentation and mixed myeloid and lymphoid expression.		2010	3153242
acute circulatory effects of doxorubicin in the conscious dog.	experimental work on the mechanisms of acute doxorubicin-induced cardiotoxicity may contribute to a better understanding of the clinical problem of cardiac failure after treatment with anthracycline derivatives. we studied aortic pressure and heart rate continuously for 1 h following a bolus injection of doxorubicin (1 mg/kg) in 7 dogs. in contrast with previous studies in intact animals, no anesthesia was used in order to eliminate possible interactions of doxorubicin with other drugs. one minu ...	1986	3153244
immunology.		2010	3153253
heredity and blood pressure in humans: an overview.	this paper presents a review of the genetic transmission of normal blood pressure and of essential hypertension. familial aggregation of normal blood pressure has been reported in adults, in children and even in newborns. blood pressure aggregation phenomenon, however, is the result of both a genetic component and shared environmental factors. more specific for each etiological factor were the studies of blood pressure aggregation in twins and in adopted children. attention was focused on the mo ...	2010	3153263
low-renin hypertension of childhood.	measurement of plasma renin activity (pra) and aldosterone with a knowledge of dietary sodium balance is critical to the diagnostic evaluation of childhood hypertension. disturbances of steroid production, regulation, metabolism and sensitivity have been implicated in the pathogenesis of low-renin hypertension in childhood. prompt initiation of treatment is essential because the hemodynamic changes caused by long-standing hypertension may become irreversible. the clinical features and hormonal f ...	2010	3153266
recent advances and controversies in childhood renal osteodystrophy.	renal osteodystrophy starts very early in chronic renal failure. although vitamin d levels are normal in patients with 70-80% function, the levels are not appropriate to the prevailing biochemical milieu. renal osteodystrophy may contribute to renal growth failure but a correlation between the degree of renal osteodystrophy and growth failure is not observed. catch-up growth cannot be obtained over a longer period of time with vitamin d. the main reason for osteomalacia is al intoxication. alumi ...	2010	3153280
renal growth after neonatal urinary tract infection.	this study presents the result of 12-21 years' follow-up in a group of children with neonatal urinary tract infection (onset within 1 month after birth) in whom early renal growth retardation was noted without concomitant classical renal scarring. in all cases the neonatal infection was diagnosed and treated within a few days of onset and the patients were closely supervised thereafter. renal length, parenchymal thickness and area were measured at urography. at first follow-up (22 children, mean ...	2010	3153287
continuous arteriovenous hemofiltration in children.	continuous arteriovenous hemofiltration (cavh) is an extracorporeal technique for the treatment of hypervolemia and electrolyte disturbances in the critically ill patient with oligoanuria. the patient's cardiac output provides the blood flow through the circuit; no pumps are necessary. a range of hemofilters is now available extending the applicability of cavh to the pediatric population, including premature newborns. in this report the treatment of 15 neonates and 8 older children is described. ...	2010	3153297