Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| in silico analysis revealed high-risk single nucleotide polymorphisms in human pentraxin-3 gene and their impact on innate immune response against microbial pathogens. | pentraxin-3 (ptx-3) protein is an evolutionary conserved protein that acts as a soluble pattern-recognition receptor for pathogens and plays important role in innate immune response. it recognizes various pathogens by interacting with extracellular moieties such as glactomannan of conidia (aspergillus fumigatus), lipopolysaccharide of pseudomonas aeruginosa, streptococcus pneumonia and salmonella typhimurium. thus, ptx-3 protein helps to clear these pathogens by activating downstream innate immu ... | 2016 | 26941719 |
| [identification of microorganisms related to chronic rhinosinusitis in adult patients with variable common immunodeficiency]. | the prevalence of chronic rhinosinusitis in adult patients with common variable immunodeficiency (cvid) is 52%. the patients with cvid show higher incidence of chronic rhinosinusitis, which is an inflammatory disease that affects the lining of one or more paranasal sinuses and nasal cavity. | 2016 | 26943827 |
| multiple brain abscesses due to aspergillus fumigatus in a patient with liver cirrhosis: a case report. | invasive cerebral aspergillosis always developed in immunocompromised host. early diagnosis may save life in this critical condition; however, it is difficult to reach. herein, we presented an unusual case of invasive cerebral aspergillosis in a cirrhotic patient. a 47-year-old man presented with progressive deterioration of consciousness for three days. the patient had a history of alcoholic liver cirrhosis, child-pugh class c. magnetic resonance imaging (mri) of brain showed multi-focal parenc ... | 2016 | 26945363 |
| comparison of the composition and antimicrobial activities of the essential oils of green branches and leaves of egyptian navel orange (citrus sinensis (l.) osbeck var. malesy). | the essential oils isolated from the leaves and green branches of the egyptian navel orange trees were analyzed by gc and gc/ms. a total of 33 and 24 compounds were identified from the oils of the leaves and branches accounting for 96.0% and 97.9%, respectively, of the total detected constituents. the major ones were sabinene (36.5; 33.0%), terpinen-4-ol (8.2; 6.2%), δ-3-carene (7.0; 9.4%), limonene (6.8; 18.7%), trans-ocimene (6.7; 6.1%), and β-myrcene (4.5; 4.4%). the antimicrobial activities ... | 2016 | 26948682 |
| co-regulation of dectin-1 and tlr2 in inflammatory response of human corneal epithelial cells induced by aspergillus fumigates. | to investigate the co-regulation of dendritic cell-associated c-type lectin-1 (dectin-1), toll-like receptor 2 (tlr2), and relative chemotactic factors in the telomease-immortalized human corneal epithelial (thce) cells after exposure to aspergillus fumigatus (af) hyphae. | 2016 | 26949633 |
| expression of s100b during the innate immune of corneal epithelium against fungi invasion. | to explore the expression of s100b in corneal epithelial cells under aspergillus stimulation both in vivo and in vitro. | 2016 | 26949634 |
| distinct roles of myosins in aspergillus fumigatus hyphal growth and pathogenesis. | myosins are a family of actin-based motor proteins found in many organisms and are categorized into classes based on their structures. class ii and v myosins are known to be important for critical cellular processes, including cytokinesis, endocytosis, exocytosis, and organelle trafficking, in the model fungi saccharomyces cerevisiae and aspergillus nidulans however, the roles of myosins in the growth and virulence of the pathogen aspergillus fumigatus are unknown. we constructed single- and dou ... | 2016 | 26953327 |
| spacer-free bodipy fluorogens in antimicrobial peptides for direct imaging of fungal infection in human tissue. | fluorescent antimicrobial peptides are promising structures for in situ, real-time imaging of fungal infection. here we report a fluorogenic probe to image aspergillus fumigatus directly in human pulmonary tissue. we have developed a fluorogenic trp-bodipy amino acid with a spacer-free c-c linkage between trp and a bodipy fluorogen, which shows remarkable fluorescence enhancement in hydrophobic microenvironments. the incorporation of our fluorogenic amino acid in short antimicrobial peptides doe ... | 2016 | 26956772 |
| inhibition of trem-1 and dectin-1 alleviates the severity of fungal keratitis by modulating innate immune responses. | to explore the possibility that inhibiting triggering receptor expressed on myeloid cells-1 (trem-1) and dendritic cell-associated c-type lectin-1(dectin-1) could modulate the innate immune response and alleviate the severity of corneal fungal keratitis. | 2016 | 26963514 |
| pkc-δ activation in neutrophils promotes fungal clearance. | the c-type lectin receptor dectin-1 and the integrin mac-1 have key roles in controlling fungal infection. here, we demonstrate that dectin-1- and mac-1-induced activation of protein kinase cδ in neutrophils, independent of the card9 adaptor, is required for reactive oxygen species production and for intracellular killing upon candida albicans uptake. protein kinase cδ was also required for zymosan-induced cytokine generation in neutrophils. in macrophages, protein kinase cδ deficiency prevented ... | 2016 | 26965632 |
| [aspergillus fumigatus mediastinitis in an immunocompetent pediatric patient after heart surgery]. | postsurgical aspergillosis occurs primarily in immunocompetent patients whose main predisposing factor is the loss of skin and mucosal integrity during surgery. local infection tends to be destructive and refractory to treatment and relapses are common. it is important to consider aspergillosis in the differential diagnosis of slowly progressive and destructive surgical site infections with negative bacterial cultures. we present the case of a child who developed aspergillus fumigatus mediastini ... | 2016 | 26965883 |
| synthesis and antimicrobial activity of bis-[4-methoxy-3-(6-aryl-7h-[1,2,4]triazolo[3,4-b][1,3,4]-thiadiazin-3-yl)phenyl]methanes and bis-[(triazolo[3,4-b]thiadiazipin-3-yl)phenyl]methanes. | a series of novel bis-[4-methoxy-3-(6-aryl-7h-[1,2,4]tria zolo[3,4-b][1,3,4]-thiadiazin-3-yl)phenyl]methanes and bis-[(triazolo[3,4-b]thiadiazipin-3-yl)phenyl]methanes ( 5a-e & 6a-e ) has been synthesized and characterized by ir, (1)h nmr, (13)c nmr, ms and elemental analysis. all the newly synthesized compounds were screened for their antibacterial activity against bacillus subtilis, staphylococcus aureus, klobsinella aerogenes and chromobacteriumviolaceum and antifungal activity against candid ... | 2016 | 26970802 |
| subcellular compartmentalization and trafficking of the biosynthetic machinery for fungal melanin. | protection by melanin depends on its subcellular location. although most filamentous fungi synthesize melanin via a polyketide synthase pathway, where and how melanin biosynthesis occurs and how it is deposited as extracellular granules remain elusive. using a forward genetic screen in the pathogen aspergillus fumigatus, we find that mutations in an endosomal sorting nexin abolish melanin cell-wall deposition. we find that all enzymes involved in the early steps of melanin biosynthesis are recru ... | 2016 | 26972005 |
| functional analysis of the gene controlling hydroxylation of festuclavine in the ergot alkaloid pathway of neosartorya fumigata. | bioactive ergot alkaloids produced by several species of fungi are important molecules in agriculture and medicine. much of the ergot alkaloid pathway has been elucidated, but a few steps, including the gene controlling hydroxylation of festuclavine to fumigaclavine b, remain unsolved. festuclavine is a key intermediate in the fumigaclavine branch of the ergot alkaloid pathway of the opportunistic pathogen neosartorya fumigata and also in the dihydrolysergic acid-based ergot alkaloid pathway of ... | 2016 | 26972831 |
| isolated orbital aspergillosis in immunocompetent patients: a multicenter study. | to report clinicopathologic features, radiologic findings, and treatment outcomes of isolated, orbital aspergillosis. | 2016 | 26973050 |
| detection of a serum siderophore by lc-ms/ms as a potential biomarker of invasive aspergillosis. | invasive aspergillosis (ia) is a life-threatening systemic mycosis caused primarily by aspergillus fumigatus. early diagnosis of ia is based, in part, on an immunoassay for circulating fungal cell wall carbohydrate, galactomannan (gm). however, a wide range of sensitivity and specificity rates have been reported for the gm test across various patient populations. to obtain iron in vivo, a. fumigatus secretes the siderophore, n,n',n"-triacetylfusarinine c (tafc) and we hypothesize that tafc may r ... | 2016 | 26974544 |
| proteomic profiling of serological responses to aspergillus fumigatus antigens in patients with invasive aspergillosis. | aspergillus fumigatus is the species that most commonly causes the opportunistic infection invasive aspergillosis (ia) in patients being treated for hematological malignancies. little is known about the a. fumigatus proteins that trigger the production of aspergillus-specific igg antibodies during the course of ia. to characterize the serological response to a. fumigatus protein antigens, mycelial proteins were separated by 2-d gel electrophoresis. the gels were immunoblotted with sera from pati ... | 2016 | 26974881 |
| in vitro interactions between target of rapamycin kinase inhibitor and antifungal agents against aspergillus species. | in vitro interactions of ink128, a target of rapamycin (tor) kinase inhibitor, and antifungals, including itraconazole, voriconazole, posaconazole, amphotericin b, and caspofungin, against aspergillus spp. were assessed with the broth microdilution checkerboard technique. our results suggested synergistic effects between ink128 and all azoles tested, against multiple aspergillus fumigatus and aspergillus flavus isolates. however, no synergistic effects were observed when ink128 was combined with ... | 2016 | 26976874 |
| comparison of reflectance confocal microscopy and two-photon second harmonic generation microscopy in fungal keratitis rabbit model ex vivo. | fungal keratitis is an infection of the cornea by fungal pathogens. diagnosis methods based on optical microscopy could be beneficial over the conventional microbiology method by allowing rapid and non-invasive examination. reflectance confocal microscopy (rcm) and two-photon second harmonic generation microscopy (tpshgm) have been applied to pre-clinical or clinical studies of fungal keratitis. in this report, rcm and tpshgm were characterized and compared in the imaging of a fungal keratitis r ... | 2016 | 26977371 |
| [tslpr/stat5 signaling modulates innate immunity in corneal fibroblasts triggered by aspergillus fumigatus]. | to study the primary role of tslpr/stat5 signaling in inflammatory responses triggered by aspergillus fumigatus(af) in telomerase-immortalized human stromal fibroblasts (thsf). | 2016 | 26979118 |
| bronchiectasis: current concepts in pathogenesis, immunology, and microbiology. | bronchiectasis is a disorder of persistent lung inflammation and recurrent infection, defined by a common pathological end point: irreversible bronchial dilatation arrived at through diverse etiologies. this suggests an interplay between immunogenetic susceptibility, immune dysregulation, bacterial infection, and lung damage. the damaged epithelium impairs mucus removal and facilitates bacterial infection with increased cough, sputum production, and airflow obstruction. lung infection is caused ... | 2016 | 26980162 |
| volatile compounds emitted by pseudomonas aeruginosa stimulate growth of the fungal pathogen aspergillus fumigatus. | chronic lung infections with opportunistic bacterial and fungal pathogens are a major cause of morbidity and mortality especially in patients with cystic fibrosis. pseudomonas aeruginosa is the most frequently colonizing bacterium in these patients, and it is often found in association with the filamentous fungus aspergillus fumigatus. p. aeruginosa is known to inhibit the growth of a. fumigatus in situations of direct contact, suggesting the existence of interspecies communication that may infl ... | 2016 | 26980832 |
| the hypoxia-induced dehydrogenase hora is required for coenzyme q10 biosynthesis, azole sensitivity and virulence of aspergillus fumigatus. | aspergillus fumigatus is the predominant airborne pathogenic fungus causing invasive aspergillosis in immunocompromised patients. during infection a. fumigatus has to adapt to oxygen-limiting conditions in inflammatory or necrotic tissue. previously, we identified a mitochondrial protein to be highly up-regulated during hypoxic adaptation. here, this protein was found to represent the novel oxidoreductase hora. in saccharomyces cerevisiae a homologue was shown to play a role in biosynthesis of c ... | 2016 | 26991818 |
| anti-aspergillus immunoglobulin-g testing in serum of hematopoietic stem cell transplant recipients. | pulmonary invasive aspergillosis (ia) is a major clinical problem in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-hsct). acquisition of ia during allo-hsct by inhalation of spores is the rationale for the widespread use of air filtration systems. recent data suggest that activation of fungal growth in already colonized patients is a relevant factor, and a recent study found a positive correlation of serum immunoglobulin responses against purified recombinant asper ... | 2016 | 26998687 |
| antimicrobial activity of the pygidial gland secretion of three ground beetle species (insecta: coleoptera: carabidae). | the antimicrobial properties of the pygidial gland secretions released by the adults of the three ground beetle species, carabus ullrichii, c. coriaceus, and abax parallelepipedus, have been tested. microdilution method was applied for detection of minimal inhibitory concentrations (mics), minimal bactericidal concentrations (mbcs), and minimal fungicidal concentrations (mfcs). additionally, morpho-histology of the pygidial glands is investigated. we have tested 16 laboratory and clinical strain ... | 2016 | 27000261 |
| hypoxia attenuates anti-aspergillus fumigatus immune responses initiated by human dendritic cells. | aspergillus fumigatus is an opportunistic mould that causes invasive pulmonary aspergillosis (ipa), a life-threatening infection in immunocompromised patients. during the course of ipa, localised areas of tissue hypoxia occur. bacterial infection models revealed that hypoxic microenvironments modulate the function of host immune cells. however, the influence of hypoxia on anti-fungal immunity has been largely unknown. we evaluated the impact of hypoxia on the human anti-a. fumigatus immune respo ... | 2016 | 27005862 |
| high prevalence of clinical and environmental triazole-resistant aspergillus fumigatus in iran: is it a challenging issue? | triazole antifungal agents are the mainstay of aspergillosis treatment. as highlighted in numerous studies, the global increase in the prevalence of triazole resistance could hamper the management of aspergillosis. in the present three-year study, 513 samples (213 clinical and 300 environmental samples) from 10 provinces of iran were processed and screened in terms of azole resistance (4 and 1 mg l-1 of itraconazole and voriconazole, respectively), using selective plates. overall, 150 a. fumigat ... | 2016 | 27008655 |
| a rare case of aspergillus pericarditis with associated myocardial abscess and echocardiographic response to therapy. | myocardial abscess is an extremely rare entity and is often deadly in nature. we present a case of a patient with recent orthotopic liver transplant, on immunosuppression, who presented with cardiac tamponade due to aspergillus fumigatus pericarditis and associated myocardial abscess. the diagnosis was made based on computed tomography imaging, culture of pericardial fluid for aspergillus, and transthoracic echocardiography. the patient received antifungal therapy with clinical improvement and d ... | 2016 | 27009593 |
| novel illudalane sesquiterpenes from encephalartos villosus lehm. antimicrobial activity. | phytochemical investigation of encephalartos villosus lehm. leaves afford two new illudalane sesquiterpenes namely encephaldiene 1 and encephaldiene 2 together with four known flavone glycosides, luteolin-7-rutinoside, luteolin-7-glucoside, luteolin-7-rhamnoside and apigenin-7-glucoside. the structures of the isolated compounds were elucidated by means of spectroscopic methods including 1d and 2d nmr experiments along with hresims spectrometry. antimicrobial activity of chcl3 and meoh extracts w ... | 2016 | 27010619 |
| vitamin d supplementation decreases aspergillus fumigatus specific th2 responses in cf patients with aspergillus sensitization: a phase one open-label study. | patients with cystic fibrosis (cf) complicated by allergic bronchopulmonary aspergillosis (abpa) are vitamin d deficient and in vitro treatment with 1,25 (oh)2 vitamin d3 of cd4+ cells from cf patients with abpa decreases aspergillus fumigatus(af)-induced th2 responses. this phase i clinical trial investigated the safety and effectiveness of daily vitamin d3 supplementation in cf patients with abpa to reduce allergic responses and abpa symptoms, and increase serum vitamin d levels. | 2017 | 27011794 |
| emerging threats in antifungal-resistant fungal pathogens. | the use of antifungal drugs in the therapy of fungal diseases can lead to the development of antifungal resistance. resistance has been described for virtually all antifungal agents in diverse pathogens, including candida and aspergillus species. the majority of resistance mechanisms have also been elucidated at the molecular level in these pathogens. drug resistance genes and genome mutations have been identified. therapeutic choices are limited for the control of fungal diseases, and it is tem ... | 2016 | 27014694 |
| characterization of a novel double-stranded rna mycovirus conferring hypovirulence from the phytopathogenic fungus botryosphaeria dothidea. | a novel double-stranded rna (dsrna) virus, designated as botryosphaeria dothidea rna virus 1 (bdrv1), isolated from a hypovirulent strain yzn115 of botryosphaeria dothidea was biologically and molecularly characterized. the genome of bdrv1 comprises of five dsrnas. each dsrna contains a single open reading frame. the proteins encoded by dsrna1-4 shared significant amino acid identities of 55%, 47%, 43% and 53% with the corresponding proteins of aspergillus fumigatus tetramycovirus-1. dsrna1, 3, ... | 2016 | 27015523 |
| functional characterization of the woronin body protein wsca of the pathogenic mold aspergillus fumigatus. | woronin bodies are fungal-specific organelles that seal damaged hyphal compartments and thereby contribute to the stress resistance and virulence of filamentous fungi. in this study, we have characterized the aspergillus fumigatus woronin body protein wsca. wsca is homologous to neurospora crassa wsc, a protein that was shown to be important for biogenesis, segregation and positioning of woronin bodies. wsca and wsc both belong to the mpv17/pmp22 family of peroxisomal membrane proteins. an a. fu ... | 2016 | 27016805 |
| antimicrobial activity of the pygidial gland secretion of the troglophilic ground beetle laemostenus (pristonychus) punctatus (dejean, 1828) (insecta: coleoptera: carabidae). | the antimicrobial activity of the pygidial gland secretion released by adult individuals of the troglophilic ground beetle laemostenus (pristonychus) punctatus (dejean, 1828), applying microdilution method with the aim to detect minimal inhibitory concentration, minimal bactericidal concentration and minimal fungicidal concentration, has been investigated. in addition, morphology of the pygidial glands is observed. we have tested 16 laboratory and clinical strains of human pathogens - eight bact ... | 2016 | 27018928 |
| high intracellular concentrations of posaconazole do not impact on functional capacities of human polymorphonuclear neutrophils and monocyte-derived macrophages in vitro. | posaconazole is a commonly used antifungal for the prophylaxis and treatment of invasive fungal infections. we previously demonstrated that the intracellular concentration of posaconazole in peripheral blood mononuclear cells (pbmcs) and polymorphonuclear neutrophils (pmns) was greatly increased compared to the plasma concentration. as these professional phagocytes are crucial to combat fungal infections, we set out to investigate if and how, beneficial or deleterious, this high loading of intra ... | 2016 | 27021317 |
| how to diagnose mould allergy? comparison of skin prick tests with specific ige results. | diagnosis of mould allergy is complicated due to the heterogeneity of the test material and the decrease in the number of commercial mould skin test solutions that are currently available. | 2016 | 27027397 |
| melanin targets lc3-associated phagocytosis (lap): a novel pathogenetic mechanism in fungal disease. | intracellular swelling of conidia of the major human airborne fungal pathogen aspergillus fumigatus results in surface exposure of immunostimulatory pathogen-associated molecular patterns (pamps) and triggers activation of a specialized autophagy pathway called lc3-associated phagocytosis (lap) to promote fungal killing. we have recently discovered that, apart from pamps exposure, cell wall melanin removal during germination of a. fumigatus is a prerequisite for activation of lap. importantly, m ... | 2016 | 27028978 |
| a retrospective study of the epidemiology and clinical manifestation of invasive aspergillosis in a major tertiary care hospital in bahrain. | limited data are available on the epidemiology, clinical manifestations and outcomes of patients with invasive aspergillosis in bahrain. this study was conducted retrospectively to determine the epidemiology of invasive aspergillosis and its risk factors, clinical presentation, underlying conditions, and outcomes over the past five years in a major hospital. the medical records of patients with positive aspergillus cultures admitted to a major tertiary care hospital in bahrain during 2009-2013 w ... | 2017 | 27033677 |
| jak/stat regulation of aspergillus fumigatus corneal infections and il-6/23-stimulated neutrophil, il-17, elastase, and mmp9 activity. | il-6 and il-23 (il-6/23) induce il-17a (il-17) production by a subpopulation of murine and human neutrophils, resulting in autocrine il-17 activation, enhanced production of reactive oxygen species, and increased fungal killing. as il-6 and il-23 receptors trigger jak1, -3/stat3 and jak2/stat3 phosphorylation, respectively, we examined the role of this pathway in a murine model of fungal keratitis and also examined neutrophil elastase and gelatinase (matrix metalloproteinase 9) activity by il-6/ ... | 2016 | 27034404 |
| from synthetic dna to pcr product: detection of fungal infections using sers. | we report the use of silver hydroxylamine nanoparticles functionalised with single stranded monothiolated dna for the detection of fungal infections. the four different species of fungi that were targeted were candida albicans, candida glabrata, candida krusei and aspergillus fumigatus. rational design of synthetic targets and probes was carried out by carefully analysing the 2-d folding of the dna and then by global alignment of the sequences to ensure specificity. the effects of varying the co ... | 2016 | 27034997 |
| a comparative study of the timecourse of the expression of the thermo‑inducible hsp70 gene in clinical and environmental isolates of aspergillus fumigatus. | the internal environment within animals or humans provides different conditions to invading saprophytic fungal pathogens, requiring the differential regulation of genes in comparison to environmental conditions. understanding the mechanisms by which pathogens regulate genes within the host may be key in determining pathogen behavior within the host and may additionally facilitate further investigation into novel therapeutic agents. the heat shock protein (hsp)70 gene and its associated proteins ... | 2016 | 27035559 |
| structural divergence of the group i intron binding surface in fungal mitochondrial tyrosyl-trna synthetases that function in rna splicing. | the mitochondrial tyrosyl-trna synthetases (mttyrrss) of pezizomycotina fungi, a subphylum that includes many pathogenic species, are bifunctional proteins that both charge mitochondrial trna(tyr) and act as splicing cofactors for autocatalytic group i introns. previous studies showed that one of these proteins, neurospora crassa cyt-18, binds group i introns by using both its n-terminal catalytic and c-terminal anticodon binding domains and that the catalytic domain uses a newly evolved group i ... | 2016 | 27036943 |
| rice-field drowning-associated pneumonia in which pseudomonas spp., aspergillus fumigatus, and cunninghamella sp. are isolated. | we herein report the case of an 84-year-old who developed pneumonia after drowning in a rice field. besides aspergillus fumigatus, many pathogens previously not reported in drowning-associated pneumonia (such as pseudomonas fluorescens, pseudomonas putida, nocardia niigatensis, and cunninghamella sp.) were isolated from his sputum. he received sulbactam/ampicillin, trimethoprim/sulfamethoxazole, voriconazole, levofloxacin and liposomal amphotericin b, but died due to respiratory failure. because ... | 2016 | 27041173 |
| the role of autophagy-related proteins in candida albicans infections. | autophagy plays an important role in maintaining cell homeostasis by providing nutrients during periods of starvation and removing damaged organelles from the cytoplasm. a marker in the autophagic process is the reversible conjugation of lc3, a membrane scaffolding protein, to double membrane autophagosomes. recently, a role for lc3 in the elimination of pathogenic bacteria and fungi, including candida albicans (c. albicans), was demonstrated, but these organisms reside in single membrane phagos ... | 2016 | 27043636 |
| fungal sensitisation in severe asthma is associated with the identification of aspergillus fumigatus in sputum. | fungal sensitisation is an important factor in severe asthma, not only for allergic bronchopulmonary aspergillosis (abpa) but also the more recently described severe asthma with fungal sensitisation (safs). it is not known whether these diseases are driven by the presence of airway fungal colonisation. we aimed to determine if both safs and abpa were associated with airway isolation of aspergillus fumigatus and whether the frequency of isolation changed following anti-fungal treatment. | 2016 | 27043956 |
| characterization of thermophilic fungal community associated with pile fermentation of pu-erh tea. | this study aimed to characterize the thermophilic fungi in pile-fermentation process of pu-erh tea. physicochemical analyses showed that the high temperature and low ph provided optimal conditions for propagation of fungi. a number of fungi, including blastobotrys adeninivorans, thermomyces lanuginosus, rasamsonia emersonii, aspergillus fumigatus, rhizomucor pusillus, rasamsonia byssochlamydoides, rasamsonia cylindrospora, aspergillus tubingensis, aspergillus niger, candida tropicalis and fusari ... | 2016 | 27046629 |
| a new antibacterial lupane ester from the seeds of acokanthera oppositifolia lam. | as a part of ongoing investigation of acokanthera oppositifolia (lam.) codd., four compounds were isolated from its seeds, a new compound; lup-20(29)-en-3β-o-(3'-β-hydroxy) palmitate (1), three known compounds; a triterpene; lupeol (2), a cardiac glycoside; acovenoside a (3) and a sterol; β-sitosterol (4). their structures were investigated using 1d & 2d- (1)h and (13)cnmr spectroscopy. antimicrobial potential of the compounds was evaluated against 10 microorganisms responsible for endocarditis. ... | 2016 | 27046822 |
| genome-wide expression profiling reveals s100b as biomarker for invasive aspergillosis. | invasive aspergillosis (ia) is a devastating opportunistic infection and its treatment constitutes a considerable burden for the health care system. immunocompromised patients are at an increased risk for ia, which is mainly caused by the species aspergillus fumigatus. an early and reliable diagnosis is required to initiate the appropriate antifungal therapy. however, diagnostic sensitivity and accuracy still needs to be improved, which can be achieved at least partly by the definition of new bi ... | 2016 | 27047454 |
| deacetylation of fungal exopolysaccharide mediates adhesion and biofilm formation. | the mold aspergillus fumigatus causes invasive infection in immunocompromised patients. recently, galactosaminogalactan (gag), an exopolysaccharide composed of galactose and n-acetylgalactosamine (galnac), was identified as a virulence factor required for biofilm formation. the molecular mechanisms underlying gag biosynthesis and gag-mediated biofilm formation were unknown. we identified a cluster of five coregulated genes that were dysregulated in gag-deficient mutants and whose gene products s ... | 2016 | 27048799 |
| gliotoxin suppresses macrophage immune function by subverting phosphatidylinositol 3,4,5-trisphosphate homeostasis. | aspergillus fumigatus, an opportunistic fungal pathogen, spreads in the environment by releasing numerous conidia that are capable of reaching the small alveolar airways of mammalian hosts. in otherwise healthy individuals, macrophages are responsible for rapidly phagocytosing and eliminating these conidia, effectively curbing their germination and consequent invasion of pulmonary tissue. however, under some circumstances, the fungus evades phagocyte-mediated immunity and persists in the respira ... | 2016 | 27048806 |
| azole susceptibility in clinical and environmental isolates of aspergillus fumigatus from eastern hokkaido, japan. | azole antifungals are used not only clinically for fungal infections but also used as agricultural fungicides. recently, azole-resistant aspergillus fumigatus containing a tandem repeat in the promoter region of cyp51a combined with amino acid substitution(s) appears in the environment in eurasia, especially in several european countries. although azole fungicides have been used in japan, especially in hokkaido, surveillance and characterization of a. fumigatus in hokkaido have not been reported ... | 2016 | 27050399 |
| invasive aspergillosis in a paediatric allogeneic stem cell transplantation recipient owing to a susceptible aspergillus fumigatus: treatment failure with high doses of voriconazole and influence of cyp2c19 polymorphisms. | 2016 | 27056297 | |
| flea expression in aspergillus fumigatus is recognized by fucosylated structures on mucins and macrophages to prevent lung infection. | the immune mechanisms that recognize inhaled aspergillus fumigatus conidia to promote their elimination from the lungs are incompletely understood. flea is a lectin expressed by aspergillus fumigatus that has twelve binding sites for fucosylated structures that are abundant in the glycan coats of multiple plant and animal proteins. the role of flea is unknown: it could bind fucose in decomposed plant matter to allow aspergillus fumigatus to thrive in soil, or it may be a virulence factor that bi ... | 2016 | 27058347 |
| antifungal susceptibility patterns of a global collection of fungal isolates: results of the sentry antifungal surveillance program (2013). | among 1846 fungal clinical isolates from 31 countries, echinocandin resistance in candida spp. ranged from 0.0% to 2.8% (highest for anidulafungin versus candida glabrata), and fluconazole resistance was noted among 11.9% and 11.6% of the c. glabrata and candida tropicalis, respectively. two isolates of aspergillus fumigatus displayed elevated mics for itraconazole and carried cyp51a mutations encoding tr34 l98h. all cryptococcus neoformans had azole mic values below epidemiological cutoff value ... | 2016 | 27061369 |
| plant-like biosynthesis of isoquinoline alkaloids in aspergillus fumigatus. | natural product discovery efforts have focused primarily on microbial biosynthetic gene clusters (bgcs) containing large multimodular polyketide synthases and nonribosomal peptide synthetases; however, sequencing of fungal genomes has revealed a vast number of bgcs containing smaller nrps-like genes of unknown biosynthetic function. using comparative metabolomics, we show that a bgc in the human pathogen aspergillus fumigatus named fsq, which contains an nrps-like gene lacking a condensation dom ... | 2016 | 27065235 |
| identification and characterization of a novel aspergillus fumigatus rhomboid family putative protease, rbda, involved in hypoxia sensing and virulence. | aspergillus fumigatus is the most common pathogenic mold infecting humans and a significant cause of morbidity and mortality in immunocompromised patients. in invasive pulmonary aspergillosis, a. fumigatus spores are inhaled into the lungs, undergoing germination and invasive hyphal growth. the fungus occludes and disrupts the blood vessels, leading to hypoxia and eventual tissue necrosis. the ability of this mold to adapt to hypoxia is regulated in part by the sterol regulatory element binding ... | 2016 | 27068092 |
| assignment of the cd cotton effect to the chiral center in pseurotins, and the stereochemical revision of pseurotin a₂. | pseurotins a₁ (1) and a₂ (2) were isolated from a culture broth of the fungal strain aspergillus fumigatus wfz-25 as stereoisomers of pseurotin a (3) in 2011. we also isolated 1 and 2 together with 3 from a. fumigatus oups-t106b-5 separated from the marine fish mugil cephalus. in this study, we re-examined the stereochemistry of 1 and 2 using chemical transformation and the cd spectra, and found the relationship between the cd cotton effect and the absolute configurations of 1 and 2, which led u ... | 2016 | 27070628 |
| infection-mediated priming of phagocytes protects against lethal secondary aspergillus fumigatus challenge. | phagocytes restrict the germination of aspergillus fumigatus conidia and prevent the establishment of invasive pulmonary aspergillosis in immunecompetent mice. here we report that immunecompetent mice recovering from a primary a. fumigatus challenge are protected against a secondary lethal challenge. using ragγc knock-out mice we show that this protection is independent of t, b and nk cells. in protected mice, lung phagocytes are recruited more rapidly and are more efficient in conidial phagocyt ... | 2016 | 27078879 |
| voriconazole-susceptible and voriconazole-resistant aspergillus fumigatus coinfection. | 2016 | 27082535 | |
| azole-resistant aspergillus fumigatus in denmark: a laboratory-based study on resistance mechanisms and genotypes. | azole-resistant aspergillus fumigatus originating from the environment as well as induced during therapy are continuously emerging in danish clinical settings. we performed a laboratory-based retrospective study (2010-2014) of azole resistance and genetic relationship of a. fumigatus at the national mycology reference laboratory of denmark. a total of 1162 clinical and 133 environmental a. fumigatus isolates were identified by morphology, thermotolerance and/or β-tubulin sequencing. screening fo ... | 2016 | 27091095 |
| hide, keep quiet, and keep low: properties that make aspergillus fumigatus a successful lung pathogen. | representatives of the genus aspergillus are opportunistic fungal pathogens. their conidia can reach the alveoli by inhalation and can give rise to infections in immunocompromised individuals. aspergillus fumigatus is the causal agent of invasive aspergillosis in nearly 90% of the cases. it is not yet well-established what makes this fungus more pathogenic than other aspergilli such as a. niger. here, we show that a. fumigatus and a. niger conidia adhere with similar efficiency to lung epithelia ... | 2016 | 27092115 |
| interactions of aspergillus fumigatus conidia with airway epithelial cells: a critical review. | aspergillus fumigatus is an environmental filamentous fungus that also acts as an opportunistic pathogen able to cause a variety of symptoms, from an allergic response to a life-threatening disseminated fungal infection. the infectious agents are inhaled conidia whose first point of contact is most likely to be an airway epithelial cell (aec). the interaction between epithelial cells and conidia is multifaceted and complex, and has implications for later steps in pathogenesis. increasing evidenc ... | 2016 | 27092126 |
| retrospective analysis of the microbiological spectrum of pneumonia in turkish patients with lung cancer. | the spectrum of pulmonary infections in patients with lung cancer is wide, and tools for target-oriented infection control measures are necessary. in this retrospective study we report the microbiological spectrum of pneumonia (based on the results of sputum culture) in a case series of turkish patients with lung malignancies. | 2016 | 27095942 |
| a green ultrasound synthesis, characterization and antibacterial evaluation of 1,4-disubstituted 1,2,3-triazoles tethering bioactive benzothiazole nucleus. | the synthesis of n-(benzo[d]thiazol-2-yl)-2-(4-substituted-1h-1,2,3-triazol-1-yl)acetamides 5a-r via the 1,3-dipolar cycloaddition reaction between 2-azido-n-(benzo[d]thiazol-2-yl)acetamide derivatives 3a-c and different alkynes were performed in the presence and absence of ultrasound irradiation. the synthesis was carried out using t-buoh/h₂o (1:1, v/v) as reaction solvents and cuso₄·5h₂o/sodium ascorbate as the catalyst. the copper catalyst was implemented to provide the regioselective 1,4-dis ... | 2016 | 27096862 |
| clinical presentation and determinants of mortality of invasive pulmonary aspergillosis in kidney transplant recipients: a multinational cohort study. | the prognostic factors and optimal therapy for invasive pulmonary aspergillosis (ipa) after kidney transplantation (kt) remain poorly studied. we included in this multinational retrospective study 112 recipients diagnosed with probable (75.0% of cases) or proven (25.0%) ipa between 2000 and 2013. the median interval from transplantation to diagnosis was 230 days. cough, fever, and expectoration were the most common symptoms at presentation. bilateral pulmonary involvement was observed in 63.6% o ... | 2016 | 27105907 |
| insights from the molecular dynamics simulation of cellobiohydrolase cel6a molecular structural model from aspergillus fumigatus nitdgpka3. | global demand for bioethanol is increasing tremendously as it could help to replace the conventional fossil fuel and at the same time supporting the bioremediation of huge volume of cellulosic wastes generated from different sources. ideal genetic engineering approaches are essential to improve the efficacy of the bioethanol production processes for real time applications. a locally isolated fungal strain aspergillus fumigatus nitdgpka3 was used in our laboratory for the hydrolysis of lignocellu ... | 2016 | 27109185 |
| fungal biofilms: update on resistance. | over the past decade, the emergence of biofilm-related invasive fungal diseases has been the subject of numerous studies focused on antifungal resistance and its impact on antifungal therapy in severely ill patients. the majority of the studies investigated the molecular mechanisms involved in antifungal resistance and pathogenicity of biofilm production by candida albicans and aspergillus fumigatus, the most common etiologic agents of yeast and mold invasive infections. the main mechanism chara ... | 2016 | 27115411 |
| structures of pathogenic fungal fkbp12s reveal possible self-catalysis function. | invasive fungal infections remain difficult to treat and require novel targeting strategies. the 12-kda fk506-binding protein (fkbp12) is a ubiquitously expressed peptidyl-prolyl isomerase with considerable homology between fungal pathogens and is thus a prime candidate for future targeting efforts to generate a panfungal strategy. despite decades of research on fkbps, their substrates and mechanisms of action remain unclear. here we describe structural, biochemical, and in vivo analyses of fkbp ... | 2016 | 27118592 |
| two-color widefield fluorescence microendoscopy enables multiplexed molecular imaging in the alveolar space of human lung tissue. | we demonstrate a fast two-color widefield fluorescence microendoscopy system capable of simultaneously detecting several disease targets in intact human ex vivo lung tissue. we characterize the system for light throughput from the excitation light emitting diodes, fluorescence collection efficiency, and chromatic focal shifts. we demonstrate the effectiveness of the instrument by imaging bacteria (pseudomonas aeruginosa) in ex vivo human lung tissue. we describe a mechanism of bacterial detectio ... | 2016 | 27121475 |
| biofilm exopolysaccharides of pathogenic fungi: lessons from bacteria. | exopolysaccharides play an important structural and functional role in the development and maintenance of microbial biofilms. although the majority of research to date has focused on the exopolysaccharide systems of biofilm-forming bacteria, recent studies have demonstrated that medically relevant fungi such as candida albicans and aspergillus fumigatus also form biofilms during infection. these fungal biofilms share many similarities with those of bacteria, including the presence of secreted ex ... | 2016 | 27129222 |
| new applications for known drugs: human glycogen synthase kinase 3 inhibitors as modulators of aspergillus fumigatus growth. | invasive aspergillosis (ia) is one of the most severe forms of fungi infection. ia disease is mainly due to aspergillus fumigatus, an air-borne opportunistic pathogen. mortality rate caused by ia is still very high (50-95%), because of difficulty in early diagnostics and reduced antifungal treatment options, thus new and efficient drugs are necessary. the aim of this work is, using aspergillus nidulans as non-pathogen model, to develop efficient drugs to treat ia. the recent discovered role of g ... | 2016 | 27131621 |
| calcineurin inhibitors impair neutrophil activity against aspergillus fumigatus in allogeneic hematopoietic stem cell transplant recipients. | neutrophils are key effectors against the widely distributed mold aspergillus fumigatus, which is a major threat for immunocompromised patients, including allogeneic hematopoietic stem cell transplant (hsct) recipients. yet little is known about neutrophil activity over time after cell transplantation, especially regarding a fumigatus. | 2016 | 27132218 |
| a non-canonical melanin biosynthesis pathway protects aspergillus terreus conidia from environmental stress. | melanins are ubiquitous pigments found in all kingdoms of life. most organisms use them for protection from environmental stress, although some fungi employ melanins as virulence determinants. the human pathogenic fungus aspergillus fumigatus and related ascomycetes produce dihydroxynaphthalene- (dhn) melanin in their spores, the conidia, and use it to inhibit phagolysosome acidification. however, biosynthetic origin of melanin in a related fungus, aspergillus terreus, has remained a mystery bec ... | 2016 | 27133313 |
| antimicrobial activity of synthesized 2-methylthiobenzo[g][1,2,4]- triazolo[1,5-a]quinazoline derivatives. | the present study was carried out to evaluate the antimicrobial activity of a synthesized 2-methylthio-benzo[g][1,2,4]triazolo[1,5- a]quinazoline series. the compounds (1-21) were tested against a variety of gram-positive bacterial species including bacillus subtilis (rcmb 01001 69-3), enterococcus faecalis (rcmb 0100154-2), staphylococcus aureus (rcmb 0100183-9), staphylococcus epidermidis (rcmb 0100183-9) and streptococcus pyogenes (rcmb 0100172-5). in addition, gram-negative bacteria were als ... | 2016 | 27140181 |
| decreased cell wall galactosaminogalactan in aspergillus nidulans mediates dysregulated inflammation in the chronic granulomatous disease host. | invasive aspergillosis is a major threat to patients suffering from impaired neutrophil function, with aspergillus fumigatus being the most common species causing this life-threatening condition. patients with chronic granulomatous disease (cgd) not only develop infections with a. fumigatus, but also exhibit a unique susceptibility to infection with the normally nonpathogenic species aspergillus nidulans. in this study, we compared the inflammatory cytokine response of peripheral blood mononucle ... | 2016 | 27142572 |
| detection of aspergillus fumigatus in blood samples from critically ill patients in intensive care units by use of the septifast assay. | we retrospectively analyzed the performance and relevance of the septifast assay in detecting aspergillus fumigatus dna in whole blood samples from 38 critically ill intensive care unit (icu) patients with probable or proven invasive aspergillosis (ia) and 100 icu patients without ia. the assay exhibited 66% sensitivity, 98% specificity, a 93% positive predictive value, and an 88% negative predictive value. a. fumigatus dnaemia was associated with poor outcome. | 2016 | 27147727 |
| application of zno nanoparticles for improving the thermal and ph stability of crude cellulase obtained from aspergillus fumigatus aa001. | cellulases are the enzymes which are responsible for the hydrolysis of cellulosic biomass. in this study thermal and ph stability of crude cellulase has been investigated in the presence of zinc oxide (zno) nanoparticles. we synthesized zno nanoparticle by sol-gel method and characterized through various techniques including, x-ray diffraction, ultraviolet-visible spectroscope, field emission scanning electron microscope and high resolution scanning electron microscope. the crude thermostable ce ... | 2016 | 27148203 |
| data-based reconstruction of gene regulatory networks of fungal pathogens. | in the emerging field of systems biology of fungal infection, one of the central roles belongs to the modeling of gene regulatory networks (grns). utilizing omics-data, grns can be predicted by mathematical modeling. here, we review current advances of data-based reconstruction of both small-scale and large-scale grns for human pathogenic fungi. the advantage of large-scale genome-wide modeling is the possibility to predict central (hub) genes and thereby indicate potential biomarkers and drug t ... | 2016 | 27148247 |
| allergic bronchopulmonary aspergillosis complicating swyer-james-macleod's syndrome: case report and review of literature. | allergic bronchopulmonary aspergillosis (abpa) is a pulmonary disorder that results from immune responses mounted against antigens of aspergillus fumigatus, resulting in non-specific respiratory symptoms and structural lung damage. classically defined in individuals suffering from bronchial asthma and cystic fibrosis, abpa has recently been described in other lung diseases including copd, pulmonary tuberculosis, idiopathic bronchiectasis and others. herein, we report the first case of abpa compl ... | 2016 | 27152607 |
| effect of plant extracts on book deteriorated fungal species. | the aim of the study was to evaluate the effect of leaf extracts of four plants against some isolated fungal species from deteriorated books. aqueous, methanol and chloroform extracts of selected plant species were screened in vitro for their antifungal activity against some book deteriorating fungal species. fifteen species belonging to 09 genera were isolated and identified from infested books in library. aqueous and solvent extracts of leaves of azadiracta indica, callistemon citrinus, eucaly ... | 2016 | 27154063 |
| cell wall integrity signalling in human pathogenic fungi. | fungi are surrounded by a rigid structure, the fungal cell wall. its plasticity and composition depend on active regulation of the underlying biosynthesis and restructuring processes. this involves specialised signalling pathways that control gene expression and activities of biosynthetic enzymes. the cell wall integrity (cwi) pathway is the central signalling cascade required for the adaptation to a wide spectrum of cell wall perturbing conditions, including heat, oxidative stress and antifunga ... | 2016 | 27155139 |
| analysis of peritoneal galactomannan for the diagnosis of aspergillus peritonitis. | here, we report a patient developing a postoperative peritoneal infection by aspergillus fumigatus. while galactomannan serum levels were negative throughout the time course, galactomannan levels in peritoneal fluids yielded high results. serological testing of peritoneal fluids for fungal antigens might be a useful and easily applicable tool to support diagnosis of intraabdominal aspergillosis, which represents a rare type of invasive fungal infection. | 2016 | 27160571 |
| expression of indoleamine 2,3-dioxygenase in a murine model of aspergillus fumigatus keratitis. | to observe the presence and expression of indoleamine 2,3-dioxygenase (ido) during the corneal immunity to aspergillus fumigatus (a. fumigatus) in the murine models. | 2016 | 27162718 |
| calcineurin orchestrates lateral transfer of aspergillus fumigatus during macrophage cell death. | pulmonary aspergillosis is a lethal mold infection in the immunocompromised host. understanding initial control of infection and how this is altered in the immunocompromised host are key goals for comprehension of the pathogenesis of pulmonary aspergillosis. | 2016 | 27163634 |
| nanoscale mo- moo3 entrapped in engineering thermoplastic: inorganic pathway to bactericidal and fungicidal action. | in our contemporary endeavor, metallic molybdenum (mo) and semiconducting molybdenum trioxide (moo3) nanostructures have been simultaneously generated via solid state reaction between molybdenum (iii) chloride (mocl3) and polyphenylene sulfide (pps) at 285 (°)c in unimolar ratio for different time durations, namely, 6 h, 24 h, and 48 h. the resultant nanocomposites (ncs) revealed formation of predominantly metallic mo for all the samples. however, moo3 gradually gained prominent position as seco ... | 2016 | 27164597 |
| biomedical and catalytic applications of gold and silver-gold alloy nanoparticles biosynthesized using cell-free extract of bacillus safensis lau 13: antifungal, dye degradation, anti-coagulant and thrombolytic activities. | this study investigated the green biosynthesis of gold (au) and silver-gold alloy (ag-au) nanoparticles using cell-free extract of bacillus safensis lau 13 strain (genbank accession no: kj461434). the biosynthesized aunps and ag-aunps were characterized using uv-vis spectroscopy, fourier-transform infrared spectroscopy, and transmission electron microscopy. evaluation of the antifungal activities, degradation of malachite green, anti-coagulation of blood, and thrombolysis of human blood clot by ... | 2016 | 27164598 |
| effects of essential oil combinations on pathogenic yeasts and moulds. | essential oils (eos) can be used as alternative or complementary antifungal agents against human pathogenic moulds and yeasts. to reduce the effective dose of antimicrobial agents, eos are combined which can lead to synergistic or additive effect. in this study the anti-yeast and anti-mould activities of selected eos were investigated, alone and in combinations, against clinical isolates of candida albicans, c. parapsilosis, aspergillus fumigatus, a. terreus, rhizopus microsporus, fusarium solan ... | 2016 | 27165531 |
| ultrasound- and molecular sieves-assisted synthesis, molecular docking and antifungal evaluation of 5-(4-(benzyloxy)-substituted phenyl)-3-((phenylamino)methyl)-1,3,4-oxadiazole-2(3h)-thiones. | a novel series of 5-(4-(benzyloxy)substituted phenyl)-3-((phenyl amino)methyl)-1,3,4-oxadiazole-2(3h)-thione mannich bases 6a-o were synthesized in good yield from the key compound 5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazole-2(3h)-thione by aminomethylation with paraformaldehyde and substituted amines using molecular sieves and sonication as green chemistry tools. the antifungal activity of the new products was evaluated against seven human pathogenic fungal strains, namely, candida albicans atcc 2 ... | 2016 | 27171073 |
| [clinical profile of sensitization to fungi in medellin, colombia]. | fungi sensitization correlates with patologies like asthma, rhinitis, conjunctivitis and dermatitis. in general it is associated with other sensitizations. in medellin the multisystemic pattern is associated with fungi sensitization. | 2016 | 27174755 |
| [prevalence of sensitization to allergens in school children with asthma residents from guadalajara metropolitan area]. | allergic sensitization is dependent on the geographical and climatic conditions in each region; therefore, identify agents most commonly sensitized children with asthma is important for planning prevention measures. | 2016 | 27174756 |
| [prevalence of sensitization to fungi in patients with respiratory allergy]. | as part of the etiology of respiratory allergy we have genetics, prenatal factors and sensitivity to various airborne allergens, between these fungi are found. relationship has been found between sensitization to fungal in skin tests and allergy pathogenesis and aggravation. there is a few literature in mexico and in the north of the country it is lacking regarding this problem. | 2016 | 27174757 |
| aspergillus infections in cystic fibrosis. | patients with cystic fibrosis (cf) suffer from chronic lung infection and airway inflammation. respiratory failure secondary to chronic or recurrent infection remains the commonest cause of death and accounts for over 90% of mortality. bacteria as staphylococcus aureus, pseudomonas aeruginosa and burkholderia cepacia complex have been regarded the main cf pathogens and their role in progressive lung decline has been studied extensively. little attention has been paid to the role of aspergillus s ... | 2016 | 27177733 |
| pharmacokinetic/pharmacodynamic analysis of voriconazole against candida spp. and aspergillus spp. in children, adolescents and adults by monte carlo simulation. | the objective of this study was to investigate the cumulative fraction of response of various voriconazole dosing regimens against six candida and six aspergillus spp. in immunocompromised children, immunocompromised adolescents, and adults. using pharmacokinetic parameters and pharmacodynamic data, 5000-subject monte carlo simulations (mcss) were conducted to evaluate the ability of simulated dosing strategies in terms of fauc/mic targets of voriconazole. according to the results of the mcss, c ... | 2016 | 27179818 |
| an epidemiological study of animals dermatomycoses in iran. | to determine the fungal species isolated from skin lesions of different animals suspected of having dermatomycoses and their prevalence in different regions of iran. | 2016 | 27180290 |
| allergic bronchopulmonary aspergillosis in a patient with rheumatoid arthritis under adalimumab therapy: a case report. | a 77-year-old woman with a 15-year history of rheumatoid arthritis (ra) was admitted to our hospital because of a wet cough that persisted for 1 month. the patient had been taking methotrexate (mtx) and adalimumab (ada) for the past 3 years, and disease activity of ra was low. discontinuation of ada and mtx and treatment with oral levofloxacin were not effective. on admission, laboratory examinations showed eosinophilia (2539/μl), elevated serum total immunoglobulin e (538.0 iu/ml) and aspergill ... | 2016 | 27181240 |
| cd11c.dtr mice develop a fatal fulminant myocarditis after local or systemic treatment with diphtheria toxin. | to assess the role of alveolar macrophages (ams) during a pulmonary aspergillus fumigatus infection ams were depleted by intratracheal application of diphtheria toxin (dtx) to transgenic cd11c.dtr mice prior to fungal infection. unexpectedly, all cd11c.dtr mice treated with dtx died within 4-5 days, whether being infected with a. fumigatus or not. despite measurable impact of dtx on lung functional parameters, these constrictions could not explain the high mortality rate. instead, dtx-treated cd ... | 2016 | 27184067 |
| comparative transcriptome analysis revealing dormant conidia and germination associated genes in aspergillus species: an essential role for atfa in conidial dormancy. | fungal conidia are usually dormant unless the extracellular conditions are right for germination. despite the importance of dormancy, little is known about the molecular mechanism underlying entry to, maintenance of, and exit from dormancy. to gain comprehensive and inter-species insights, transcriptome analyses were conducted across aspergillus fumigatus, aspergillus niger, and aspergillus oryzae. | 2016 | 27185182 |
| lc3-associated phagocytosis: a crucial mechanism for antifungal host defence against aspergillus fumigatus. | lc3-associated phagocytosis (lap) is a non-canonical autophagy pathway involved in the maturation of single-membrane phagosomes and subsequent killing of ingested pathogens by phagocytes. this pathway is initiated following recognition of pathogens by pattern recognition receptors and leads to the recruitment of lc3 into the phagosomal membrane. this form of phagocytosis is utilized for the antifungal host defence and is required for an efficient fungal killing. here, we provide an overview of t ... | 2016 | 27185357 |
| predictors of deterioration of lung function in polish children with cystic fibrosis. | severity of lung disease varies in patients with the same cftr genotype. it suggests that other factors affect the severity of cystic fibrosis (cf). the aim of the study was to identify risk factors that determine lung function decline in polish cystic fibrosis children. | 2016 | 27186187 |
| phylogenetic and structural analysis of polyketide synthases in aspergilli. | polyketide synthases (pkss) of aspergillus species are multidomain and multifunctional megaenzymes that play an important role in the synthesis of diverse polyketide compounds. putative pks protein sequences from aspergillus species representing medically, agriculturally, and industrially important aspergillus species were chosen and screened for in silico studies. six candidate aspergillus species, aspergillus fumigatus af293, aspergillus flavus nrrl3357, aspergillus niger cbs 513.88, aspergill ... | 2016 | 27199544 |