Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| engagement of siglec-7 receptor induces a pro-inflammatory response selectively in monocytes. | sialic acid binding immunoglobulin-like lectin-7 (siglec-7) is a trans-membrane receptor carrying immunoreceptor tyrosine based inhibitory motifs (itims) and delivering inhibitory signals upon ligation with sialylated glycans. this inhibitory function can be also targeted by several pathogens that have evolved to express sialic acids on their surface to escape host immune responses. here, we demonstrate that cross-linking of siglec-7 by a specific monoclonal antibody (mab) induces a remarkably h ... | 2012 | 23029261 |
| sigma factor n, liaison to an ntrc and rpos dependent regulatory pathway controlling acid resistance and the lee in enterohemorrhagic escherichia coli. | enterohemorrhagic escherichia coli (ehec) is dependent on acid resistance for gastric passage and low oral infectious dose, and the locus of enterocyte effacement (lee) for intestinal colonization. mutation of rpon, encoding sigma factor n (σ(n)), dramatically alters the growth-phase dependent regulation of both acid resistance and the lee. this study reports on the determinants of σ(n)-directed acid resistance and lee expression, and the underlying mechanism attributable to this phenotype. glut ... | 2012 | 23029465 |
| enhanced adhesion of campylobacter jejuni to abiotic surfaces is mediated by membrane proteins in oxygen-enriched conditions. | campylobacter jejuni is responsible for the major foodborne bacterial enteritis in humans. in contradiction with its fastidious growth requirements, this microaerobic pathogen can survive in aerobic food environments, suggesting that it must employ a variety of protection mechanisms to resist oxidative stress. for the first time, c. jejuni 81-176 inner and outer membrane subproteomes were analyzed separately using two-dimensional protein electrophoresis (2-de) of oxygen-acclimated cells and micr ... | 2012 | 23029510 |
| effects of feeding finisher pigs with chicory or lupine feed for one week or two weeks before slaughter with respect to levels of bifidobacteria and campylobacter. | this study aimed to assess whether inclusion of chicory or lupine (prebiotics) in the diet of pre-slaughter pigs for just 1 or 2 weeks could change the composition of their intestinal microbiota, stimulate the growth of bifidobacteria and help to lower the amount of thermoplilic campylobacter spp. (mainly campylobacter jejuni and campylobacter coli), which are a major cause of food-borne infections in humans. a total of 48 pigs that had an initial live weight of 90 kg were fed with either a lupi ... | 2013 | 23031645 |
| adaptive and mutational resistance: role of porins and efflux pumps in drug resistance. | the substantial use of antibiotics in the clinic, combined with a dearth of new antibiotic classes, has led to a gradual increase in the resistance of bacterial pathogens to these compounds. among the various mechanisms by which bacteria endure the action of antibiotics, those affecting influx and efflux are of particular importance, as they limit the interaction of the drug with its intracellular targets and, consequently, its deleterious effects on the cell. this review evaluates the impact of ... | 2012 | 23034325 |
| porphyromonas gingivalis entry into gingival epithelial cells modulated by fusobacterium nucleatum is dependent on lipid rafts. | host cell invasion by a major periodontal pathogen, porphyromonas gingivalis, has been proposed as an important mechanism involved in host-pathogen interactions in periodontal and cardiovascular diseases. the present study sought to gain insight into the underlying mechanism(s) involved in previously demonstrated fusobacterial modulation of host cell invasion by p. gingivalis. an immortalized human gingival cell line ca9-22 was dually infected with p. gingivalis atcc 33277 and fusobacterium nucl ... | 2012 | 23034475 |
| the methylomes of six bacteria. | six bacterial genomes, geobacter metallireducens gs-15, chromohalobacter salexigens, vibrio breoganii 1c-10, bacillus cereus atcc 10987, campylobacter jejuni subsp. jejuni 81-176 and c. jejuni nctc 11168, all of which had previously been sequenced using other platforms were re-sequenced using single-molecule, real-time (smrt) sequencing specifically to analyze their methylomes. in every case a number of new n(6)-methyladenine ((m6)a) and n(4)-methylcytosine ((m4)c) methylation patterns were disc ... | 2012 | 23034806 |
| a small multidrug resistance-like transporter involved in the arabinosylation of arabinogalactan and lipoarabinomannan in mycobacteria. | the biosynthesis of the major cell envelope glycoconjugates of mycobacterium tuberculosis is topologically split across the plasma membrane, yet nothing is known of the transporters required for the translocation of lipid-linked sugar donors and oligosaccharide intermediates from the cytoplasmic to the periplasmic side of the membrane in mycobacteria. one of the mechanisms used by prokaryotes to translocate lipid-linked phosphate sugars across the plasma membrane relies on translocases that shar ... | 2012 | 23038254 |
| campylobacter spp. - prevalence on pig livers and antimicrobial susceptibility. | the objective of the study was to determine the prevalence of campylobacter spp. on surfaces of slaughtered pig livers. multilocus sequence typing (mlst) was performed to determine the sequence types (sts) of selected campylobacter coli isolates. additionally, c. coli and campylobacter jejuni isolates were tested for antimicrobial susceptibility by the broth dilution method. the minimal inhibitory concentrations were determined for erythromycin, gentamicin, ampicillin, ampicillin/sulbactam, nali ... | 2013 | 23040119 |
| biophysical and bioinformatic analyses implicate the treponema pallidum tp34 lipoprotein (tp0971) in transition metal homeostasis. | metal ion homeostasis is a critical function of many integral and peripheral membrane proteins. the genome of the etiologic agent of syphilis, treponema pallidum, is compact and devoid of many metabolic enzyme genes. nevertheless, it harbors genes coding for homologs of several enzymes that typically require either iron or zinc. the product of the tp0971 gene of t. pallidum, designated tp34, is a periplasmic lipoprotein that is thought to be tethered to the inner membrane of this organism. previ ... | 2012 | 23042995 |
| common variable immunodeficiency: an update. | common variable immunodeficiency (cvid) describes a heterogeneous subset of hypogammaglobulinemias of unknown etiology. typically, patients present with recurrent bacterial infections of the respiratory and gastrointestinal tract. a significant proportion of cvid patients develops additional autoimmune, inflammatory or lymphoproliferative complications. cvid is the most frequent symptomatic primary immunodeficiency encountered in adults. informative monogenetic defects have been found in single ... | 2012 | 23043756 |
| control of campylobacter jejuni in chicken breast meat by irradiation combined with modified atmosphere packaging including carbon monoxide. | campylobacter is one of the leading causes of human foodborne illnesses originating from meat and poultry products. cross-contamination of this organism occurs in many poultry processing plants, and can occur in the kitchens and refrigerators of consumers. therefore, new intervention strategies are needed for meat and poultry products to better protect consumers from this pathogen. vacuum or modified atmosphere packaging is a common packaging technique used by the meat and poultry industry to ex ... | 2012 | 23043819 |
| antibiotic resistance in bacterial pathogens from retail raw meats and food-producing animals in japan. | to determine the prevalence and antimicrobial susceptibility profiles of campylobacter, salmonella, staphylococcus aureus, methicillin-resistant s. aureus (mrsa), and vancomycin-resistant enterococci (vre) in food-producing animals and retail raw meats in japan, raw meat samples as well as food-producing animal feces, cutaneous swabs, and nasal swabs collected from 2004 to 2006 were analyzed. isolation rates of campylobacter jejuni and campylobacter coli, salmonella, and s. aureus were 34.6% (36 ... | 2012 | 23043825 |
| antibiotic susceptibility of salmonella, campylobacter coli, and campylobacter jejuni isolated from northern german fattening pigs. | this study was conducted to assess the antimicrobial susceptibility rate of salmonella and campylobacter spp. isolated from northern german fattening pigs. from 540 lymph node samples, 16 salmonella typhimurium, 1 salmonella brandenburg, 37 campylobacter coli, and 11 campylobacter jejuni strains were isolated. antibiotic susceptibility testing was carried out by the broth dilution method. the 14 tested antibiotics for salmonella were ampicillin, cefotaxime, ceftazidime, chloramphenicol, ciproflo ... | 2012 | 23043834 |
| the cell pole: the site of cross talk between the dna uptake and genetic recombination machinery. | natural transformation is a programmed mechanism characterized by binding of free double-stranded (ds) dna from the environment to the cell pole in rod-shaped bacteria. in bacillus subtilis some competence proteins, which process the dsdna and translocate single-stranded (ss) dna into the cytosol, recruit a set of recombination proteins mainly to one of the cell poles. a subset of single-stranded binding proteins, working as "guardians", protects ssdna from degradation and limit the reca recombi ... | 2012 | 23046409 |
| re-sequencing of a virulent strain of campylobacter jejuni nctc11168 reveals potential virulence factors. | in vitro passage of campylobacter jejuni strains results in phenotypic changes and a general loss of virulence, as is the case with the genome-sequenced strain c. jejuni nctc11168. re-sequencing of a virulent strain of nctc11168 identified 41 snps or indels involving 20 genes, four intergenic regions and three pseudogenes. the genes include six motility genes, two chemotaxis genes, three hypothetical genes and a capsule biosynthesis gene, which might have a critical role in c. jejuni virulence. ... | 2013 | 23046762 |
| global network alignment using multiscale spectral signatures. | protein interaction networks provide an important system-level view of biological processes. one of the fundamental problems in biological network analysis is the global alignment of a pair of networks, which puts the proteins of one network into correspondence with the proteins of another network in a manner that conserves their interactions while respecting other evidence of their homology. by providing a mapping between the networks of different species, alignments can be used to inform hypot ... | 2012 | 23047556 |
| the natural antimicrobial carvacrol inhibits campylobacter jejuni motility and infection of epithelial cells. | natural compounds with anti-microbial properties are attractive reagents to reduce the use of conventional antibiotics. carvacrol, the main constituent of oregano oil, inhibits the growth of a variety of bacterial foodborne pathogens. as concentrations of carvacrol may vary in vivo or when used in animal feed, we here investigated the effect of subinhibitory concentrations of the compound on major virulence traits of the principal bacterial foodborne pathogen campylobacter jejuni. | 2012 | 23049787 |
| natural transformation of campylobacter jejuni occurs beyond limits of growth. | campylobacter jejuni is a human bacterial pathogen. while poultry is considered to be a major source of food borne campylobacteriosis, c. jejuni is frequently found in the external environment, and water is another well-known source of human infections. natural transformation is considered to be one of the main mechanisms for mediating transfer of genetic material and evolution of the organism. given the diverse habitats of c. jejuni we set out to examine how environmental conditions and physiol ... | 2012 | 23049803 |
| a novel plasmid-encoded serotype conversion mechanism through addition of phosphoethanolamine to the o-antigen of shigella flexneri. | shigella flexneri is the major pathogen causing bacillary dysentery in developing countries. s. flexneri is divided into at least 16 serotypes based on the combination of antigenic determinants present in the o-antigen. all the serotypes (except for serotype 6) share a basic o-unit containing one n-acetyl-d-glucosamine and three l-rhamnose residues, whereas differences between the serotypes are conferred by phage-encoded glucosylation and/or o-acetylation. serotype xv is a newly emerged and the ... | 2012 | 23049947 |
| attenuation of streptococcus suis virulence by the alteration of bacterial surface architecture. | neub, a sialic acid synthase catalyzes the last committed step of the de novo biosynthetic pathway of sialic acid, a major element of bacterial surface structure. here we report a functional neub homologue of streptococcus suis, a zoonotic agent, and systematically address its molecular and immunological role in bacterial virulence. disruption of neub led to thinner capsules and more susceptibility to ph, and cps2b inactivation resulted in complete absence of capsular polysaccharides. these two ... | 2012 | 23050094 |
| detection of salmonella spp., candida albicans, aspergillus spp., and antimicrobial residues in raw and processed cow milk from selected smallholder farms of zimbabwe. | a cross-sectional study was conducted to detect the presence of salmonella spp., candida albicans, aspergillus spp., and antimicrobial residues in raw milk (n = 120) and processed cow milk (n = 20) from smallholder dairy farms from three sites in zimbabwe. culture and isolation of salmonella spp., c. albicans, and aspergillus spp. were performed using selective media, while antimicrobial residues were detected by a dye reduction test. no salmonella, but c. albicans (17.5%; 21/120), aspergillus s ... | 2012 | 23050199 |
| effect of environmental stress factors on the uptake and survival of campylobacter jejuni in acanthamoeba castellanii. | campylobacter jejuni is a major cause of bacterial food-borne illness in europe and north america. the mechanisms allowing survival in the environment and transmission to new hosts are not well understood. environmental free-living protozoa may facilitate both processes. pre-exposure to heat, starvation, oxidative or osmotic stresses encountered in the environment may affect the subsequent interaction of c. jejuni with free-living protozoa. to test this hypothesis, we examined the impact of envi ... | 2012 | 23051891 |
| campylobacter jejuni csra complements an escherichia coli csra mutation for the regulation of biofilm formation, motility and cellular morphology but not glycogen accumulation. | although campylobacter jejuni is consistently ranked as one of the leading causes of bacterial diarrhea worldwide, the mechanisms by which c. jejuni causes disease and how they are regulated have yet to be clearly defined. the global regulator, csra, has been well characterized in several bacterial genera and is known to regulate a number of independent pathways via a post transcriptional mechanism, but remains relatively uncharacterized in the genus campylobacter. previously, we reported data i ... | 2012 | 23051923 |
| genotypic characterization of streptococcus infantarius subsp. coli isolates from sea otters with infective endocarditis and/or septicemia and from environmental mussel samples. | pulsed-field gel electrophoresis (pfge) was used to type 128 streptococcus infantarius subsp. coli isolates from sea otters and mussels. six smai pfge groups were detected, with one predominant group representing 57% of the isolates collected over a wide geographic region. several sea otter and mussel isolates were highly related, suggesting that an environmental infection source is possible. | 2012 | 23052307 |
| engineering, conjugation, and immunogenicity assessment of escherichia coli o121 o antigen for its potential use as a typhoid vaccine component. | state-of-the-art production technologies for conjugate vaccines are complex, multi-step processes. an alternative approach to produce glycoconjugates is based on the bacterial n-linked protein glycosylation system first described in campylobacter jejuni. the c. jejuni n-glycosylation system has been successfully transferred into escherichia coli, enabling in vivo production of customized recombinant glycoproteins. however, some antigenic bacterial cell surface polysaccharides, like the vi antige ... | 2013 | 23053636 |
| the crystal structures of the α-subunit of the α(2)β (2) tetrameric glycyl-trna synthetase. | aminoacyl-trna synthetases (aarss) are ligases (ec.6.1.1.-) that catalyze the acylation of amino acids to their cognate trnas in the process of translating genetic information from mrna to protein. their amino acid and trna specificity are crucial for correctly translating the genetic code. glycine is the smallest amino acid and the glycyl-trna synthetase (glyrs) belongs to class ii aarss. the enzyme is unusual because it can assume different quaternary structures. in eukaryotes, archaebacteria ... | 2012 | 23054484 |
| options for treating resistant shigella species infections in children. | infection due to shigella species remains an important public health problem, especially in developing countries where it remains the most common cause of bloody diarrhea. in the united states (us), 10,000 to 15,000 cases of shigellosis are reported each year in both children and adults. us surveillance data from 2004 has demonstrated increased resistance in shigella species to first-line antibiotics such as ampicillin and trimethoprim-sulfamethoxazole, with approximately 37% of isolates demonst ... | 2008 | 23055862 |
| optimal treatment of campylobacter dysentery. | 2008 | 23055879 | |
| a novel insight into the oxidoreductase activity of helicobacter pylori hp0231 protein. | the formation of a disulfide bond between two cysteine residues stabilizes protein structure. although we now have a good understanding of the escherichia coli disulfide formation system, the machineries at work in other bacteria, including pathogens, are poorly characterized. thus, the objective of this work was to improve our understanding of the disulfide formation machinery of helicobacter pylori, a leading cause of ulcers and a risk factor for stomach cancer worldwide. | 2012 | 23056345 |
| comparative transcriptional analysis of homologous pathogenic and non-pathogenic lawsonia intracellularis isolates in infected porcine cells. | lawsonia intracellularis is the causative agent of proliferative enteropathy. this disease affects various animal species, including nonhuman primates, has been endemic in pigs, and is an emerging concern in horses. non-pathogenic variants obtained through multiple passages in vitro do not induce disease, but bacterial isolates at low passage induce clinical and pathological changes. we hypothesize that genes differentially expressed between pathogenic (passage 10) and non-pathogenic (passage 60 ... | 2012 | 23056413 |
| the interaction of helicobacter pylori with the adherent mucus gel layer secreted by polarized ht29-mtx-e12 cells. | helicobacter pylori colonises the gastric mucosa of humans. the majority of organisms live in mucus. these organisms are an important reservoir for infection of the underlying epithelium. cell culture models for h. pylori infection do not normally possess a mucus layer. the interaction of h. pylori with tff1, a member of the trefoil factor family found in gastric mucin, is mediated by lipopolysaccharide. to test the hypothesis that the interaction of h. pylori with tff1 promotes mucus colonizati ... | 2012 | 23056622 |
| bacterial toxin modulation of the eukaryotic cell cycle: are all cytolethal distending toxins created equally? | the cytolethal distending toxins (cdts) comprise a family of intracellular-acting bacterial protein toxins whose actions upon eukaryotic cells result in several consequences, the most characteristic of which is the induction of g(2)/m cell cycle arrest. most cdts are hetero-tripartite assemblies of cdta, cdtb, and cdtc, with cdtb required for cdt-mediated cell cycle arrest. several lines of evidence indicate that cdta and cdtc are required for the optimal intracellular activity of cdtb, although ... | 2012 | 23061054 |
| transcriptional regulation of the cmeabc multidrug efflux pump and the kata catalase by cosr in campylobacter jejuni. | cosr is an essential response regulator in campylobacter jejuni, a major food-borne pathogen causing enteritis worldwide. a transcriptomic analysis performed in this study discovered 93 genes whose transcriptional levels were changed >2-fold due to the repression of cosr expression by antisense peptide nucleic acid. the identified cosr-regulated genes are involved in various cellular functions, such as energy production, protein synthesis and folding, flagellum biogenesis, and lipid metabolism. ... | 2012 | 23065977 |
| the kizss network, a sentinel surveillance system for infectious diseases in day care centers: study protocol. | day care-associated infectious diseases are widely recognized as a public health problem but rarely studied. insights into their dynamics and their association with the day care setting are important for effective decision making in management of infectious disease control. this paper describes the purpose, design and potential of our national multi-center, day care-based sentinel surveillance network for infectious diseases (the kizss network). the aim of the kizss network is to acquire a long- ... | 2012 | 23066727 |
| infectious disease outbreaks in competitive sports, 2005-2010. | old, evolving, and new infectious agents continually threaten the participation of competitors in sports. | 2012 | 23068588 |
| characterization of the polymyxin b resistome of pseudomonas aeruginosa. | multidrug resistance in pseudomonas aeruginosa is increasingly becoming a threat for human health. indeed, some strains are resistant to almost all currently available antibiotics, leaving very limited choices for antimicrobial therapy. in many such cases, polymyxins are the only available option, although as their utilization increases so does the isolation of resistant strains. in this study, we screened a comprehensive pa14 mutant library to identify genes involved in changes of susceptibilit ... | 2013 | 23070157 |
| recent trends in vaccine delivery systems: a review. | vaccines are the preparations given to patients to evoke immune responses leading to the production of antibodies (humoral) or cell-mediated responses that will combat infectious agents or noninfectious conditions such as malignancies. alarming safety profile of live vaccines, weak immunogenicity of sub-unit vaccines and immunization, failure due to poor patient compliance to booster doses which should potentiate prime doses are few strong reasons, which necessitated the development of new gener ... | 2011 | 23071924 |
| rapid and sensitive detection of plesiomonas shigelloides by loop-mediated isothermal amplification of the huga gene. | plesiomonas shigelloides is one of the causative agents of human gastroenteritis, with increasing number of reports describing such infections in recent years. in this study, the huga gene was chosen as the target to design loop-mediated isothermal amplification (lamp) assays for the rapid, specific, and sensitive detection of p. shigelloides. the performance of the assay with reference plasmids and spiked human stools as samples was evaluated and compared with those of quantitative pcr (qpcr). ... | 2012 | 23077478 |
| automatic assignment of prokaryotic genes to functional categories using literature profiling. | in the last years, there was an exponential increase in the number of publicly available genomes. once finished, most genome projects lack financial support to review annotations. a few of these gene annotations are based on a combination of bioinformatics evidence, however, in most cases, annotations are based solely on sequence similarity to a previously known gene, which was most probably annotated in the same way. as a result, a large number of predicted genes remain unassigned to any functi ... | 2012 | 23077617 |
| bioluminescent enzyme immunoassay for the detection of norovirus capsid antigen. | an ultrasensitive and fully automated bioluminescent enzyme immunoassay (bleia) was developed for the detection of norovirus (nv) capsid antigen. in the evaluation tests with recombinant virus-like particles, the bleia demonstrated broad reactivity against several nv genotypes (genotypes 1, 3, 4, 7, 8, and 12 in genogroup i [gi] and genotypes 1, 2, 3, 4, 5, 6, 12, and 13 in gii), a wide dose-response range from 0.25 pg/ml to 10,000 pg/ml, and good reproducibility with low coefficients of variati ... | 2012 | 23081816 |
| abdominal ultrasonographic findings in typhoid fever: a comparison between typhoid patients and those with non-typhoidal salmonella and campylobacter jejuni enterocolitis. | typhoid fever is a major health problem in many developing countries and its clinical features are similar to other types of bacterial enterocolitis. definitive diagnosis by blood culture requires several days and is often unfeasible to perform in developing countries. more efficient and rapid diagnostic methods for typhoid are needed. we compared the pathological changes in the bowel and adjacent tissues of patients having typhoid fever with those having bacterial enterocolitis using ultrasonog ... | 2012 | 23082592 |
| colonization of campylobacter spp. in broiler chickens and laying hens reared in tropical climates with low-biosecurity housing. | the onset and prevalence of campylobacter colonization in broilers and layers at commercial farms with low biosecurity in tropical climates were tested. despite the presence of positive animals at the same farms, the broiler flocks tested negative until, on average, 21 days. prelaying flocks showed a higher prevalence than laying flocks. | 2013 | 23087035 |
| redundancy and modularity in membrane-associated dissimilatory nitrate reduction in bacillus. | the genomes of two phenotypically denitrifying type strains of the genus bacillus were sequenced and the pathways for dissimilatory nitrate reduction were reconstructed. results suggest that denitrification proceeds in the periplasmic space and in an analogous fashion as in gram-negative organisms, yet with the participation of proteins that tend to be membrane-bound or membrane-associated. a considerable degree of functional redundancy was observed with marked differences between b. azotoforman ... | 2012 | 23087684 |
| identification of burkholderia cenocepacia strain h111 virulence factors using nonmammalian infection hosts. | burkholderia cenocepacia h111, a strain isolated from a cystic fibrosis patient, has been shown to effectively kill the nematode caenorhabditis elegans. we used the c. elegans model of infection to screen a mini-tn5 mutant library of b. cenocepacia h111 for attenuated virulence. of the approximately 5,500 b. cenocepacia h111 random mini-tn5 insertion mutants that were screened, 22 showed attenuated virulence in c. elegans. except for the quorum-sensing regulator cepr, none of the mutated genes c ... | 2013 | 23090963 |
| characterization and structure of the aquifex aeolicus protein duf752: a bacterial trna-methyltransferase (mnmc2) functioning without the usually fused oxidase domain (mnmc1). | post-transcriptional modifications of the wobble uridine (u34) of trnas play a critical role in reading nna/g codons belonging to split codon boxes. in a subset of escherichia coli trna, this wobble uridine is modified to 5-methylaminomethyluridine (mnm(5)u34) through sequential enzymatic reactions. uridine 34 is first converted to 5-carboxymethylaminomethyluridine (cmnm(5)u34) by the mnme-mnmg enzyme complex. the cmnm(5)u34 is further modified to mnm(5)u by the bifunctional mnmc protein. in the ... | 2012 | 23091054 |
| pulmonary streptomyces infection in patient with sarcoidosis, france, 2012. | to the editor: streptomyces spp. are aerobic, gram-positive bacteria of the order actinomycetales, known for their ability to produce antimicrobial molecules such as streptomycin. streptomyces spp., usually saprophytic to humans, can cause local cutaneous fistulized nodules known as actinomycetoma or mycetoma. severe invasive infections have seldom been reported, but most cases reported have occurred in immunocompromised patients (1-5). we report a case of invasive pulmonary infection caused by ... | 2012 | 23092549 |
| pediatric renal inflammatory myofibroblastic tumours: a case report and review of the etiology and management options. | inflammatory myofibroblastic tumours (imts) have been described in lung, bladder, spleen, breast, pancreas, liver, colon, spermatic cord, prostate, peripheral nerves, orbit and kidney. traditionally believed as having a reactive pathogenesis, imts are now viewed more as a neoplasm. this report describes a case of a renal imt in a 14-year-old girl with spina bifida associated neurogenic bladder and a history of recurrent urinary tract infections. this represents a unique case as pediatric renal i ... | 2012 | 23093568 |
| potential of peptides as inhibitors and mimotopes: selection of carbohydrate-mimetic peptides from phage display libraries. | glycoconjugates play various roles in biological processes. in particular, oligosaccharides on the surface of animal cells are involved in virus infection and cell-cell communication. inhibitors of carbohydrate-protein interactions are potential antiviral drugs. several anti-influenza drugs such as oseltamivir and zanamivir are derivatives of sialic acid, which inhibits neuraminidase. however, it is very difficult to prepare a diverse range of sugar derivatives by chemical synthesis or by the is ... | 2012 | 23094142 |
| comparison of adhesion, invasion, motility, and toxin production of campylobacter strains and their resistant mutants. | the objectives of this study were to compare the in vitro adhesion and invasion of human epithelial cells, motility, and toxin production characteristics of campylobacter-susceptible strains and their fluoroquinolone- or macrolide-resistant mutants. susceptible strains and resistant mutants demonstrated similar adhesion capacities to epithelial cells. for campylobacter coli, fluoroquinolone-resistant mutants with thr86ile or asp90asn substitutions showed a higher rate of invasion of caco-2 cells ... | 2013 | 23095083 |
| antimicrobial resistance patterns and corresponding multilocus sequence types of the campylobacter jejuni isolates from human diarrheal samples. | a total of 121 campylobacter isolates from 4,788 humans with gastroenteritis were identified and characterized by biochemical detection methods, polymerase chain reaction, and multilocus sequence typing (mlst). these samples were obtained during a 3-year period, from january 2007 to december 2009, using the national notifiable diseases surveillance system at the research institute of public health and environment in seoul metropolitan, korea. antimicrobial susceptibilities of the bacterium were ... | 2013 | 23098555 |
| gene function hypotheses for the campylobacter jejuni glycome generated by a logic-based approach. | increasingly, experimental data on biological systems are obtained from several sources and computational approaches are required to integrate this information and derive models for the function of the system. here, we demonstrate the power of a logic-based machine learning approach to propose hypotheses for gene function integrating information from two diverse experimental approaches. specifically, we use inductive logic programming that automatically proposes hypotheses explaining the empiric ... | 2013 | 23103756 |
| sensitive and rapid detection of campylobacter jejuni and campylobacter coli using loop-mediated isothermal amplification. | loop-mediated isothermal amplification (lamp) is an established nucleic acid amplification method offering rapid, accurate, and cost-effective diagnosis of infectious diseases. from the beginning of dna extraction to final detection of campylobacter jejuni and campylobacter coli, the assay requires less than 50 and 90 min from a colony on selective media, and human feces, respectively. for chicken meat samples, the assay requires approximately 24-48 h from the beginning of the enrichment culture ... | 2013 | 23104296 |
| solution structure of escherichia coli feoa and its potential role in bacterial ferrous iron transport. | iron is an indispensable nutrient for most organisms. ferric iron (fe(3+)) predominates under aerobic conditions, while during oxygen limitation ferrous (fe(2+)) iron is usually present. the feo system is a bacterial ferrous iron transport system first discovered in escherichia coli k-12. it consists of three genes, feoa, feob, and feoc (yhgg). feob is thought to be the main transmembrane transporter while feoc is considered to be a transcriptional regulator. using multidimensional nuclear magne ... | 2013 | 23104801 |
| complete genome sequence of a variant of campylobacter jejuni nctc 11168. | campylobacter jejuni nctc 11168 is widely used in research, but at least two variants have been reported. the available genome was sequenced from a variant which later showed a different phenotype and gene expression profile. here we present the complete genome sequence of a second variant of c. jejuni nctc 11168. | 2012 | 23105049 |
| cysq of cryptosporidium parvum, a protozoa, may have been acquired from bacteria by horizontal gene transfer. | horizontal gene transfer (hgt) is the movement of genetic material between kingdoms and is considered to play a positive role in adaptation. cryptosporidium parvum is a parasitic protozoan that causes an infectious disease. its genome sequencing reported 14 bacteria-like proteins in the nuclear genome. among them, cgd2_1810, which has been annotated as cysq, a sulfite synthesis pathway protein, is listed as one of the candidates of genes horizontally transferred from bacterial origin. in this re ... | 2012 | 23105923 |
| role of cytolethal distending toxin in altered stool form and bowel phenotypes in a rat model of post-infectious irritable bowel syndrome. | campylobacter jejuni infection is a leading cause of acute gastroenteritis, which is a trigger for post-infectious irritable bowel syndrome (pi-ibs). cytolethal distending toxin (cdt) is expressed by enteric pathogens that cause pi-ibs. we used a rat model of pi-ibs to investigate the role of cdt in long-term altered stool form and bowel phenotypes. | 2012 | 23106005 |
| rapid detection and respirometric profiling of aerobic bacteria on panels of selective media. | to evaluate high-throughput optical oxygen microrespirometry for selective detection and predictive identification of aerobic bacteria. | 2013 | 23107004 |
| susceptibility of campylobacter to high intensity near ultraviolet/visible 395±5nm light and its effectiveness for the decontamination of raw chicken and contact surfaces. | campylobacter is an important cause of human gastroenteritis worldwide. chicken meat is frequently contaminated with this organism and is considered to be a significant source of infection. it has been predicted that lowering the numbers of campylobacter on chicken meat can reduce the risk to public health. the aims of the current study were to investigate the susceptibility of campylobacter to high intensity near ultraviolet/visible (nuv-vis) 395±5nm light and to examine its potential for the m ... | 2012 | 23107507 |
| development of a feed additive to reduce caecal campylobacter jejuni in broilers at slaughter age: from in vitro to in vivo, a proof of concept. | in vitro and in vivo challenge studies were undertaken to develop an in-feed additive of microencapsulated propionic, sorbic acids and pure botanicals to control campylobacter jejuni in broilers at slaughter age. | 2013 | 23110383 |
| lab-on-a-chip pathogen sensors for food safety. | there have been a number of cases of foodborne illness among humans that are caused by pathogens such as escherichia coli o157:h7, salmonella typhimurium, etc. the current practices to detect such pathogenic agents are cell culturing, immunoassays, or polymerase chain reactions (pcrs). these methods are essentially laboratory-based methods that are not at all real-time and thus unavailable for early-monitoring of such pathogens. they are also very difficult to implement in the field. lab-on-a-ch ... | 2012 | 23112625 |
| identification of essential genes of the periodontal pathogen porphyromonas gingivalis. | porphyromonas gingivalis is a gram-negative anaerobic bacterium associated with periodontal disease onset and progression. genetic tools for the manipulation of bacterial genomes allow for in-depth mechanistic studies of metabolism, physiology, interspecies and host-pathogen interactions. analysis of the essential genes, protein-coding sequences necessary for survival of p. gingivalis by transposon mutagenesis has not previously been attempted due to the limitations of available transposon syste ... | 2012 | 23114059 |
| genome reduction promotes increase in protein functional complexity in bacteria. | obligate pathogenic and endosymbiotic bacteria typically experience gene loss due to functional redundancy, asexuality, and genetic drift. we hypothesize that reduced genomes increase their functional complexity through protein multitasking, in which many genes adopt new roles to counteract gene loss. comparisons of interaction networks among six bacteria that have varied genome sizes (mycoplasma pneumoniae, treponema pallidum, helicobacter pylori, campylobacter jejuni, synechocystis sp., and my ... | 2013 | 23114380 |
| functional glycomic analysis of human milk glycans reveals the presence of virus receptors and embryonic stem cell biomarkers. | human milk contains a large diversity of free glycans beyond lactose, but their functions are not well understood. to explore their functional recognition, here we describe a shotgun glycan microarray prepared from isolated human milk glycans (hmgs), and our studies on their recognition by viruses, antibodies, and glycan-binding proteins (gbps), including lectins. the total neutral and sialylated hmgs were derivatized with a bifunctional fluorescent tag, separated by multidimensional hplc, and a ... | 2012 | 23115247 |
| using major outer membrane protein typing as an epidemiological tool to investigate outbreaks caused by milk-borne campylobacter jejuni isolates in california. | we describe using major outer membrane protein (momp) typing as a screen to compare the campylobacter jejuni pora gene sequences of clinical outbreak strains from human stool with the pora sequences of dairy farm strains isolated during two milk-borne campylobacteriosis outbreak investigations in california. the genetic relatedness of clinical and environmental strains with identical or closely related pora sequences was confirmed by multilocus sequence typing and pulsed-field gel electrophoresi ... | 2013 | 23115263 |
| a unique host defense pathway: trif mediates both antiviral and antibacterial immune responses. | both anti-viral and anti-bacterial host defense mechanisms involve trif signaling. trif provides early clearance of pathogens and coordination of a local inflammatory ensemble through an interferon cascade, while it may trigger organ damage. the multipotentiality of trif-mediated immune machinery may direct the fate of our continuous battle with microbes. | 2012 | 23116944 |
| a unique host defense pathway: trif mediates both antiviral and antibacterial immune responses. | both anti-viral and anti-bacterial host defense mechanisms involve trif signaling. trif provides early clearance of pathogens and coordination of a local inflammatory ensemble through an interferon cascade, while it may trigger organ damage. the multipotentiality of trif-mediated immune machinery may direct the fate of our continuous battle with microbes. | 2012 | 23116944 |
| gangliosides and sialic acid effects upon newborn pathogenic bacteria adhesion: an in vitro study. | the effect of the main gangliosides (gm(1), gm(3), gd(3)) and free sialic acid (neu5ac) upon the adhesion of pathogenic bacteria implicated in infant diarrhoea is assessed in vitro using the caco-2 cell line. concentrations of the bioactive compounds found in the bioaccessible (soluble) fraction of infant formula and human milk are employed. bacterial adhesion behaviour included enterotoxigenic escherichia coli (etec), enteropathogenic e.coli (epec), listeria monocytogenes, salmonella entericase ... | 2013 | 23122120 |
| in vitro evaluation of the probiotic potential of lactobacillus salivarius smxd51. | lactobacillus salivarius smxd51 was previously isolated from the cecum of a tunisian poultry and found to produce a bacteriocin-like substance highly active against the foodborne pathogen campylobacter jejuni. the aim of this study was to examine some probiotic properties of the strain: acid and bile tolerance, capacity of adhesion, stimulation of immune defences (il-6, il-8, il-10 and β-defensin 2), and modulation of the barrier integrity. the results showed that l. salivarius smxd51 can tolera ... | 2012 | 23122647 |
| molecular characterization of human-pathogenic microsporidia and cyclospora cayetanensis isolated from various water sources in spain: a year-long longitudinal study. | recent studies suggest the involvement of water in the epidemiology of cyclospora cayetanensis and some microsporidia. a total of 223 samples from four drinking water treatment plants (dwtps), seven wastewater treatment plants (wwtps), and six locations of influence (li) on four river basins from madrid, spain, were analyzed from spring 2008 to winter 2009. microsporidia were detected in 49% of samples (109/223), cyclospora spp. were detected in 9% (20/223), and both parasites were found in 5.4% ... | 2013 | 23124243 |
| comparison of multilocus sequence typing (mlst) and repetitive sequence-based pcr (rep-pcr) fingerprinting for differentiation of campylobacter jejuni isolated from broiler in chiang mai, thailand. | we compared rapid fingerprinting using repetitive sequence-based pcr (rep-pcr) for subtyping campylobacter jejuni isolates to the widely used multilocus sequence typing (mlst). representative c. jejuni isolates (n = 16) from broilers were analyzed using mlst and rep-pcr. both techniques demonstrated an equal discriminatory power of 0.8917, and 9 subgroups were identified. clonal identification of all 16 isolates was identical for both techniques. the rep-pcr as described in this study may be use ... | 2012 | 23124335 |
| a new generation microarray for the simultaneous detection and identification of yersinia pestis and bacillus anthracis in food. | the use of microarrays as a multiple analytic system has generated increased interest and provided a powerful analytical tool for the simultaneous detection of pathogens in a single experiment. a wide array of applications for this technology has been reported. a low density oligonucleotide microarray was generated from the genetic sequences of y. pestis and b. anthracis and used to fabricate a microarray chip. the new generation chip, consisting of 2,240 spots in 4 quadrants with the capability ... | 2012 | 23125935 |
| quantitative risk assessment of verocytotoxin-producing escherichia coli o157 and campylobacter jejuni related to consumption of raw milk in a province in northern italy. | a quantitative risk assessment was developed to describe the risk of campylobacteriosis and hemolytic uremic syndrome (hus) linked to consumption of raw milk sold in vending machines in northern italy. exposure assessment considered the microbiological status of dairy farms, expected milk contamination, storage conditions from bulk tank to home storage, microbial growth during storage, destruction experiments, consumption frequency of raw milk, age of consumers, serving size, and consumption pre ... | 2012 | 23127713 |
| novel aminoglycoside 2''-phosphotransferase identified in a gram-negative pathogen. | aminoglycoside 2″-phosphotransferases are the major aminoglycoside-modifying enzymes in clinical isolates of enterococci and staphylococci. we describe a novel aminoglycoside 2″-phosphotransferase from the gram-negative pathogen campylobacter jejuni, which shares 78% amino acid sequence identity with the aph(2″)-ia domain of the bifunctional aminoglycoside-modifying enzyme aminoglycoside (6') acetyltransferase-ie/aminoglycoside 2″-phosphotransferase-ia or aac(6')-ie/aph(2″)-ia from gram-positive ... | 2013 | 23129050 |
| a case of helicobacter cinaedi bacteremia in an asplenic patient. | helicobacter cinaedi is an enterohepatic species. it can cause bacteremia, gastroenteritis, and cellulitis, particularly in immunocompromised individuals, such as those with acquired immunodeficiency syndrome, malignancy, or alcoholism. there are no previous reports of h. cinaedi infection in korea. a 71-yr-old man was admitted to the emergency room because of dyspnea on november 9, 2011. he had undergone splenectomy 3 yr ago because of immune hemolytic anemia. chest plain radiography revealed b ... | 2012 | 23130344 |
| eosinophils in infection and intestinal immunity. | inflammatory bowel diseases (ibds, e.g., crohn's disease and ulcerative colitis) are thought to be a consequence of an uncontrolled inflammatory response against luminal antigens, including commensal bacteria. the observed link between eosinophil levels and severity and remission rates in ibd has led to speculation that eosinophils may contribute to the antimicrobial inflammatory response in ibd. | 2013 | 23132211 |
| prevalence and antimicrobial resistance of thermophilic campylobacter isolated from chicken in côte d'ivoire. | thermophilic campylobacters are major causes of gastroenteritis in human. the main risk factor of infection is consumption of contaminated or by cross-contaminated poultry meat. in côte d'ivoire, gastroenteritis is usually observed but no case of human campylobacteriosis has been formally reported to date. the aims of this study were to determine prevalence and antimicrobial resistance of campylobacter jejuni and campylobacter coli isolated from chickens ceaca in commercial slaughter in abidjan. ... | 2012 | 23133454 |
| mucin biopolymers prevent bacterial aggregation by retaining cells in the free-swimming state. | many species of bacteria form surface-attached communities known as biofilms. surrounded in secreted polymers, these aggregates are difficult both to prevent and eradicate, posing problems for medicine and industry. humans play host to hundreds of trillions of microbes that live adjacent to our epithelia, and we are typically able to prevent harmful colonization. mucus, the hydrogel overlying all wet epithelia in the body, can prevent bacterial contact with the underlying tissue. the digestive t ... | 2012 | 23142047 |
| hypothesis: bacteria control host appetites. | to help investigate the relationship between inflammatory and other diseases and the composition of the gut microbiota, we propose that a positive-feedback loop exists between the preferences of the host for a particular dietary regimen, the composition of the gut microbiota that depends on this regimen, and the preferences of the host as influenced by the gut microbiota. we cite evidence in support of this hypothesis and make testable predictions. | 2013 | 23144247 |
| molecular evidence for the thriving of campylobacter jejuni st-4526 in japan. | campylobacter jejuni is a leading cause of human gastroenteritis worldwide. this study aimed at a better understanding of the genetic diversity of this pathogen disseminated in japan. we performed multilocus sequence typing (mlst) of campylobacter jejuni isolated from different sources (100 human, 61 poultry, and 51 cattle isolates) in japan between 2005 and 2006. this approach identified 62 sequence types (sts) and 19 clonal complexes (ccs), including 11 novel sts. these 62 sts were phylogeneti ... | 2012 | 23144873 |
| crystal structures of the helicobacter pylori mtan enzyme reveal specific interactions between s-adenosylhomocysteine and the 5'-alkylthio binding subsite. | the bacterial 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase (mtan) enzyme is a multifunctional enzyme that catalyzes the hydrolysis of the n-ribosidic bond of at least four different adenosine-based metabolites: s-adenosylhomocysteine (sah), 5'-methylthioadenosine (mta), 5'-deoxyadenosine (5'-doa), and 6-amino-6-deoxyfutalosine. these activities place the enzyme at the hub of seven fundamental bacterial metabolic pathways: s-adenosylmethionine (sam) utilization, polyamine biosynthes ... | 2012 | 23148563 |
| respiratory proteins contribute differentially to campylobacter jejuni's survival and in vitro interaction with hosts' intestinal cells. | the genetic features that facilitate campylobacter jejuni's adaptation to a wide range of environments are not completely defined. however, whole genome expression studies showed that respiratory proteins (rps) were differentially expressed under varying conditions and stresses, suggesting further unidentified roles for rps in c. jejuni's adaptation. therefore, our objectives were to characterize the contributions of selected rps to c. jejuni's i- key survival phenotypes under different temperat ... | 2012 | 23148765 |
| molecular-based detection of the gastrointestinal pathogen campylobacter ureolyticus in unpasteurized milk samples from two cattle farms in ireland. | campylobacter jejuni and coli are collectively regarded as the most prevalent cause of bacterial foodborne illness worldwide. an emerging species, campylobacter ureolyticus has recently been detected in patients with gastroenteritis, however, the source of this organism has, until now, remained unclear. herein, we describe the molecular-based detection of this pathogen in bovine faeces (1/20) and unpasteurized milk (6/47) but not in poultry (chicken wings and caeca). this is, to the best of our ... | 2012 | 23151337 |
| detection of campylobacter species and arcobacter butzleri in stool samples by use of real-time multiplex pcr. | the presence of campylobacter (or campylobacter-like) species in stools from patients suspected of infectious gastroenteritis (n = 493) was investigated using real-time pcr for detection of arcobacter butzleri (hsp60 gene), campylobacter coli (ceue gene), campylobacter jejuni (mapa), five acknowledged pathogenic campylobacter spp. (c16s_lund assay), and the campylobacter genus (c16s_lvi assay). in total, 71.4% of the samples were positive for campylobacter dna (n = 352) by a campylobacter genus- ... | 2013 | 23152553 |
| capillary electrophoresis with three-color fluorescence detection for the analysis of glycosphingolipid metabolism. | a capillary electrophoresis system with an ultrasensitive three-color laser-induced fluorescence detector was constructed for the simultaneous measurement of glycosphingolipids conjugated with a family of bodipy fluorophores. the compounds were separated by capillary electrophoresis and detected by laser-induced fluorescence excited within a sheath-flow cuvette. diode-pumped solid-state lasers operating at 473 nm and 532 nm, and a diode laser operating at 633 nm were used to excite glycosphingol ... | 2012 | 23154386 |
| capillary electrophoresis with three-color fluorescence detection for the analysis of glycosphingolipid metabolism. | a capillary electrophoresis system with an ultrasensitive three-color laser-induced fluorescence detector was constructed for the simultaneous measurement of glycosphingolipids conjugated with a family of bodipy fluorophores. the compounds were separated by capillary electrophoresis and detected by laser-induced fluorescence excited within a sheath-flow cuvette. diode-pumped solid-state lasers operating at 473 nm and 532 nm, and a diode laser operating at 633 nm were used to excite glycosphingol ... | 2012 | 23154386 |
| insertion mutations in helicobacter pylori flha reveal strain differences in rpon-dependent gene expression. | flagellar biogenesis in the gastric pathogen helicobacter pylori involves a transcriptional hierarchy that utilizes all three sigma factors found in this bacterium (rpod, rpon and flia). transcription of the rpon-dependent genes requires the sensor kinase flgs and response regulator flgr. it is thought that flgs senses some cellular cue to regulate transcription of the rpon-dependent flagellar genes, but this signal has yet to be identified. previous studies showed that transcription of the rpon ... | 2013 | 23154969 |
| different imaging findings of inflammatory myofibroblastic tumor of the liver. | inflammatory myofibroblastic tumor (imt) in the liver is an uncommon lesion of uncertain pathogenesis. in most cases, symptomatological imaging and clinical studies suggest malignancy. we report a case of liver imt with imaging findings from positron emission tomography/computed tomography (pet/ct), contrast-enhanced computed tomography (cect) and contrast-enhanced ultrasonography (ceus). this report was the first to depict a pet/ct scan of a liver imt that revealed an inhomogeneous, intense (fl ... | 2012 | 23155327 |
| celiac disease: prevalence, diagnosis, pathogenesis and treatment. | celiac disease (cd) is one of the most common diseases, resulting from both environmental (gluten) and genetic factors [human leukocyte antigen (hla) and non-hla genes]. the prevalence of cd has been estimated to approximate 0.5%-1% in different parts of the world. however, the population with diabetes, autoimmune disorder or relatives of cd individuals have even higher risk for the development of cd, at least in part, because of shared hla typing. gliadin gains access to the basal surface of th ... | 2012 | 23155333 |
| mechanistic and structural basis for inhibition of thymidylate synthase thyx. | nature has established two mechanistically and structurally unrelated families of thymidylate synthases that produce de novo thymidylate or dtmp, an essential dna precursor. representatives of the alternative flavin-dependent thymidylate synthase family, thyx, are found in a large number of microbial genomes, but are absent in humans. we have exploited the nucleotide binding pocket of thyx proteins to identify non-substrate-based tight-binding thyx inhibitors that inhibited growth of genetically ... | 2012 | 23155486 |
| malt lymphoma in labial salivary gland biopsy from sjögren syndrome: importance of follow-up in early detection. | mucosa-associated lymphoid tissue (malt) lymphomas are known to occur in sjögren syndrome (ss) patients, but reported cases in labial salivary glands (lsg) are rare. we report a case of 60-year-old female patient with ss who developed malt lymphoma in the labial salivary glands during a 2-year time interval when she was participating in the sjögren's international clinical collaborative alliance, an ongoing longitudinal multisite observational study funded by the national institutes of health of ... | 2012 | 23157989 |
| malt lymphoma in labial salivary gland biopsy from sjögren syndrome: importance of follow-up in early detection. | mucosa-associated lymphoid tissue (malt) lymphomas are known to occur in sjögren syndrome (ss) patients, but reported cases in labial salivary glands (lsg) are rare. we report a case of 60-year-old female patient with ss who developed malt lymphoma in the labial salivary glands during a 2-year time interval when she was participating in the sjögren's international clinical collaborative alliance, an ongoing longitudinal multisite observational study funded by the national institutes of health of ... | 2012 | 23157989 |
| effects of efflux-pump inducers and genetic variation of the multidrug transporter cmeb in biocide resistance of campylobacter jejuni and campylobacter coli. | multidrug efflux pumps, such as cmeabc and cmedef, are involved in the resistance of campylobacter to a broad spectrum of antimicrobials. the aim of this study was to analyse the effects of two putative efflux-pump inducers, bile salts and sodium deoxycholate, on the resistance of campylobacter to biocides (triclosan, benzalkonium chloride, chlorhexidine diacetate, cetylpyridinium chloride and trisodium phosphate), sds and erythromycin. the involvement of the cmeabc and cmedef efflux pumps in th ... | 2013 | 23161768 |
| two unusual variants of guillain-barre syndrome. | guillain-barre syndrome (gbs) is a group of autoimmune diseases characterised by acute, acquired and immune-mediated polyneuroradiculopathy. a large number of clinical subtypes of gbs have been described over last 100 years since the first description of this syndrome. we report two such cases gbs variants--first, aman with brisk reflexes and second being acute motor axonal neuropathy with conduction block. through this case report, we intend to make the treating physicians and neurologist aware ... | 2012 | 23162026 |
| nod1 and nod2 signaling in infection and inflammation. | sensing intracellular pathogens is a process mediated by innate immune cells that is crucial for the induction of inflammatory processes and effective adaptive immune responses against pathogenic microbes. nod-like receptors (nlrs) comprise a family of intracellular pattern recognition receptors that are important for the recognition of damage and microbial-associated molecular patterns. nod1 and nod2 are specialized nlrs that participate in the recognition of a subset of pathogenic microorganis ... | 2012 | 23162548 |
| interactions between parasites and microbial communities in the human gut. | the interactions between intestinal microbiota, immune system, and pathogens describe the human gut as a complex ecosystem, where all components play a relevant role in modulating each other and in the maintenance of homeostasis. the balance among the gut microbiota and the human body appear to be crucial for health maintenance. intestinal parasites, both protozoans and helminths, interact with the microbial community modifying the balance between host and commensal microbiota. on the other hand ... | 2012 | 23162802 |
| [role of infectious agents in the emergence of malignant tumors]. | according to the data of the international agency for research on cancer (iarc), at least 6 virus species (hpv, ebv, hhv-8/kshv, htlv-1, hbv, hcv), 4 helminthes species (schistosoma haematobium and japonicum, opisthorchis viverrini, clonorchis sinensis) and i bacterium species (helicobacter pylori) have been proved to be capable of causing the development of cancer. the analysis of the data available shows that merkel cell polyomavirus (mcv), herpes simplex virus (hsv), john cunningham polyomavi ... | 2012 | 23163048 |
| application of ozonated dry ice (aligal™ blue ice) for packaging and transport in the food industry. | dry ice is used by meat and poultry processors for temperature reduction during processing and for temperature maintenance during transportation. aligal™ blue ice (abi), which combines the antimicrobial effect of ozone (o(3)) along with the high cooling capacity of dry ice, was investigated for its effect on bacterial reduction in air, in liquid, and on food and glass surfaces. through proprietary means, o(3) was introduced to produce dry ice pellets to a concentration of 20 parts per million (p ... | 2012 | 23163945 |
| research considerations for more effective groundwater monitoring. | since numerous pathogens occur in feces, water is monitored for fecal contamination using indicator organisms rather than individual pathogens. although this approach is supported by health effects data in recreational waters, it is questionable when used for drinking water. most outbreaks in groundwater occur in systems that have not violated the us epa's maximum contaminant limit (mcl) for total coliforms within 12 months before the outbreak. additionally, environmentally stable viruses and pa ... | 2012 | 23165708 |
| the nose knows not: poor predictive value of stool sample odor for detection of clostridium difficile. | 2013 | 23166192 |