Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| [a case of hcc with portal vein thrombosis treated with multidisciplinary treatment combined with preoperative sbrt and radical resection]. | a 70s man with advanced hepatocellular carcinoma (hcc) with portal vein tumor thrombosis (pvtt) (vp-hcc) in the main trunk (vp4) was referred to our hospital. he was negative for hepatitis c virus (hcv) and hepatitis b virus (hbv), and his liver function was well preserved. the main tumor was in the right lobe and exceeded 10 cm in diameter. there were no intrahepatic metastases to the left lobe. the patient underwent stereotactic body radiation therapy (sbrt) (48 gy/4 fractions) to the area of ... | 2014 | 25731445 |
| activation of type i and type iii interferons in chronic hepatitis c. | infection with hepatitis c virus (hcv) results in chronic and progressive liver disease. persistency rates add up to 85%. despite recognition of the virus by the human host in peripheral blood and in the liver, immune response appears to be ineffective in clearing infection. the ability to spontaneously eradicate the virus as well as the outcome of infection upon therapy with human recombinant interferon-α (ifn-α) was found to correlate most closely with genetic variations within the region enco ... | 2015 | 25766746 |
| fibrosing cholestatic hepatitis after successful interferon and ribavirin therapy for recurrent hepatitis c post living related liver transplantation: a case report. | a 33-year-old japanese man who had suffered from liver cirrhosis due to hepatitis c virus (hcv) underwent living related liver transplantation (lrlt). the allograft was given by his brother, who was healthy with no history of hepatitis or hepatic virus infection. after lrlt, the patient's hepatitis c recurred. liver biopsy revealed chronic viral hepatitis and no allograft rejection such as shown by portal lymphocytic infiltration or mild bridging fibrosis. interferon and ribavirin were administe ... | 2014 | 25803885 |
| two patients treated with simeprevir plus pegylated-interferon and ribavirin triple therapy for recurrent hepatitis c after living donor liver transplantation: case report. | we previously reported our data on telaprevir (tvr) used in combination with pegylated-interferon and ribavirin (peg-ifn/rbv) for the treatment of recurrent hepatitis c virus (hcv) genotype 1 infection after liver transplantation (lt). tvr substantially increases the blood levels of immunosuppressive agents such as cyclosporine and tacrolimus for drug-drug interactions. on the other hand, the effect of simeprevir (smv) on the blood levels of these immunosuppressive agents is unclear. we report 2 ... | 2015 | 25891736 |
| renal biopsy in a patient with haemophilia a and cryoglobulinaemic membranoproliferative glomerulonephritis associated with hepatitis c virus infection. | a renal biopsy was performed in a 47-year-old man with haemophilia a. thirty minutes after administration of an intravenous bolus of 4000 units of recombinant factor viii, which increased the activity to 74-91%, a needle renal biopsy was successfully performed, followed by administration of 3000 units of factor viii in the evening, and then the subsequent morning and evening. the patient was diagnosed with hepatitis c virus-associated membranoproliferative glomerulonephritis. treatment with inte ... | 2009 | 25949347 |
| assessment of interleukin 28b genotype as a predictor of response to combined therapy with pegylated interferon plus ribavirin in hcv infected egyptian patients. | single nucleotide polymorphisms (snps) of interleukin 28b (il28b) gene is associated with spontaneous clearance and variable response to combined therapy with pegylated interferon (peg-ifn) and ribavirin (rbv) in chronic hepatitis c virus (hcv) infected patients. this study aimed at assessing the value of il28b rs8099917 gene polymorphism in predicting sustained virological response (svr) among hcv infected egyptian patients treated with peg-ifn and rbv. | 2015 | 26003758 |
| leg ulcer as a manifestation of eosinophilic vasculitis in a patient with hepatitis c virus infection, medicated with pegylated interferon/ribavirin. | cryoglobulinaemic vasculitis is a complication of hepatitis c virus (hcv) infection, responding to treatment with pegylated interferon (peg-ifn)/ribavirin (rib), but vasculitis may first appear after treatment with peg-ifn/rib. a 35-year-old man with hcv infection presented to our department with a 2-month history of a 3.3 × 3 cm ulcer localised on the right shin, with a regular border, on a violaceous base. histopathological examination revealed a leucocytoclastic vasculitis, rich in eosinophil ... | 2015 | 26065548 |
| hepatitis c and leptospirosis: simultaneous acute infections or recurrence of occult hepatitis c. | people who inject drugs are vulnerable to several infections. to the best of our knowledge, this is the first case report of a simultaneous diagnosis of leptospirosis and acute infection or recurrence of occult hepatitis c in an hiv-infected drug user. we report a case of a 47-year-old caucasian man with hiv infection, on antiretroviral therapy, and with a history of hepatitis c (positive anti-hepatitis c virus (hcv) and hcv rna persistently negative) who was admitted with febrile acute hepatiti ... | 2015 | 26135490 |
| multiple sclerosis like condition in a patient of hepatitis c after treatment with interferon alpha: a case report. | hepatitis c virus affects millions of people around the world. the primary therapy comprises of interferon alpha and ribavarin. the most common side effects of this treatment include flu like symptoms and psychiatric issues. one of the rare complications of the combined therapy is the development of demyelinating lesions in the central nervous system. our case report presents a 35-year-old man who was a known case of hepatitis c presenting to us with altered level of consciousness and decreased ... | 2015 | 26155513 |
| the first case of deceased donor liver transplantation for a patient with end-stage liver cirrhosis due to human immunodeficiency virus and hepatitis c virus coinfection in japan. | we previously reported that progression of liver cirrhosis is quicker and survival is dismal in patients with human immunodeficiency virus (hiv) and hepatitis c virus (hcv) coinfection, especially when acquired in childhood through contaminated blood products. recently, we performed the first deceased donor liver transplantation (ddlt) for an hiv/hcv-coinfected hemophilic patient in japan. a 40-year-old man was referred to our hospital for liver transplantation. regular ddlt was performed using ... | 2016 | 26166505 |
| a case of hemorrhagic gastroduodenitis after proton beam radiation for pancreatic cancer with multiple hemorrhagic risk factors: successful treatment with argon plasma coagulation. | radiation-induced gastroduodenitis is a well-known but rare disorder causing uncontrollable hemorrhage and has not been reported as a complication of proton beam therapy in radiation treatment. argon plasma coagulation (apc) has been shown to be effective and safe in the management of radiation-induced hemorrhagic gastroduodenitis. we describe a case of hemorrhagic gastroduodenitis after proton beam radiation therapy for pancreatic cancer with multiple hemorrhagic risk factors, which was treated ... | 2012 | 26181072 |
| spontaneous regression of hepatocellular carcinoma repeated 3 times with invasion of portal vein and inferior vena cava: report on a rare case. | a 65-year-old man suffered from advanced hepatocellular carcinoma in the right lobe of the liver, for which he received no treatment. his serum was positive for hepatitis c antibody. in spite of his poor prognosis, he remained in good clinical condition and at 6-month follow-up the tumor had regressed without specific treatment, as assessed both radiologically and from a decrease of a previously elevated serum tumor marker level (1st regression). the tumor regrew in size, but at 23-month follow- ... | 2012 | 26181873 |
| a case of hepatitis c-associated osteosclerosis that was improved with the combination therapy of peginterferon alfa-2b and ribavirin. | hepatitis c-associated osteosclerosis (hcao) is a rare disorder characterized by a marked increase in skeletal mass in patients who are infected with hepatitis c virus (hcv). the clinical presentation is an acquired deep bone pain with increased serum alkaline phosphatase (alp) activity. we present a case of a patient with hcao who was treated with antiviral therapy. a 42-year-old japanese man presented with severe, stabbing pain in his lower limbs. he was diagnosed with hepatitis c secondary to ... | 2011 | 26189530 |
| a case of intrahepatic cholangiocarcinoma detected after successful interferon therapy for chronic hepatitis c. | a 65-year-old man presented at our hospital in 2006 because of a liver tumor. he had been treated for chronic hepatitis c with interferon-α2b for 6 months in 1998. a pathological examination showed that the hepatic tissue before interferon (ifn) therapy was classified as moderately active hepatitis with severe hepatic fibrosis. the ifn therapy induced the disappearance of the hepatitis c virus (hcv) rna from his serum and normalized alanine aminotransferase activity. in 2005, a tumor (2 cm in di ... | 2010 | 26189907 |
| a case of acute hepatitis c caused by interspousal transmission after 30 years of marriage. | we describe a case of interspousal transmission of hepatitis c virus (hcv) infection after 30 years of marriage which was confirmed by gene analysis. a 60-year-old man was referred to our hospital because of severe hepatic dysfunction. laboratory findings showed that hcv-ab titer and qualitative amplicor hcv were both positive in low levels. because the patient regularly consumes various health foods, it was initially difficult to rule out drug-induced hepatopathy, but the patient was diagnosed ... | 2010 | 26189908 |
| a case of liver cirrhosis due to hepatits c virus infection complicating giant anorectal varices treated with balloon-occluded retrograde transvenous obliteration. | a 73-year-old man with liver cirrhosis due to hepatitis c virus infection was admitted to our hospital because of massive bleeding from external varices. colonoscopic examination revealed that giant anorectal varices had developed between the anus and rectal ampulla, and had ruptured at the perianal site. on three-dimensional computed tomography imaging, the feeding and drainage vessels of the varices were identified as the inferior mesenteric vein and right inferior hemorrhoidal vein, respectiv ... | 2011 | 26190616 |
| spontaneous regression of diffuse intrahepatic recurrence with portal vein tumor thrombus after resection of hepatocellular carcinoma. | we report a rare case of spontaneous regression of diffuse intrahepatic recurrence with portal vein tumor thrombus (pvtt) after resection of hepatocellular carcinoma (hcc). a 68-year-old man with hepatitis c virus-related liver cirrhosis presented with a 40 mm tumor in the right anterior segment of the liver. the tumor was diagnosed as hcc by typical imaging findings and elevated serum alpha-fetoprotein (afp) (716 ng/ml) and protein induced by vitamin k absence ii (pivka ii) (8,100 ng/ml). a rig ... | 2011 | 26190621 |
| interferon therapy following treatment of recurrent hepatocellular carcinoma in an 83-year-old man with hepatitis c virus-related liver cirrhosis. | a sustained virological response and improvement of liver function were achieved by low-dose interferon (ifn) therapy following curative treatment of initial and recurrent hepatocellular carcinoma (hcc) in an 83-year-old man with hepatitis c virus (hcv)-related liver cirrhosis (clc). although a fourth hcc episode recurred 16 months after ifn therapy, it was successfully treated. the patient is still alive 6 years and 7 months after diagnosis of the initial hcc and has been in a tumor-free state ... | 2011 | 26190718 |
| autoimmune hepatitis triggered by treatment with pegylated interferon α-2a and ribavirin for chronic hepatitis c. | hepatitis flare is rarely observed during treatment with pegylated interferon alpha for hepatitis c virus (hcv) infection. a 49-year-old man receiving pegylated interferon α-2a for hcv infection had icterus and hyperbiliru-binemia in the 14th week of therapy, with hcv rna undetectable after the 12th dose. liver biopsy was suggestive of chronic hepatitis with cirrhosis without interface pattern. pegylated interferon was discontinued; a few weeks later, his aminotransferases and immunoglobulin lev ... | 2015 | 26203454 |
| management of sleep quality and pain in an individual living with hiv and hepatitis c coinfection using an activity monitor. | case report. | 2016 | 26307209 |
| an hepatitis c virus (hcv)/hiv co-infected patient who developed severe hepatitis during chronic hcv infection: sustained viral response with simeprevir plus peginterferon-alpha and ribavirin. | we herein describe the case of a 42-year-old man who developed severe hepatitis caused by hepatitis c virus (hcv) infection at 14 years after the start of human immunodeficiency virus (hiv) treatment. surprisingly, the levels of alanine aminotransferase (alt) fluctuated, reaching a peak higher than 1,000 iu/l during chronic hcv infection, and the hepatic histology showed advanced liver fibrosis at 3 years after the primary hcv infection. he was treated with simeprevir, peginterferon-alpha, and r ... | 2015 | 26328642 |
| a case of cryoglobulinemic membranoproliferative glomerulonephritis induced by hepatitis c virus. | a 61-year-old man with bilateral purpura of the lower limbs and subsequent edema, was hospitalization after renal dysfunction developed. the presence of hepatitis c virus (hcv) rna and cryoglobulin and the finding of membranoproliferative glomerulonephritis on renal biopsy led to a diagnosis of hcv-related glomerulonephritis due to cryoglobulinemia. because of the pre-existence of nephrotic syndrome and the continuously increasing serum level of creatinine, treatment with cryofiltration, interfe ... | 2015 | 26328796 |
| spontaneous clearance of hcv accompanying hepatitis after liver transplantation. | re-infection by the hepatitis c virus (hcv) occurs rapidly after liver transplantation (lt), and spontaneous clearance of hcv is rare under immunosuppressive conditions. here, we report on two patients who underwent lt to treat liver cirrhosis and hepatocellular carcinoma. the immunosuppressants prescribed were short-term corticosteroids, tacrolimus, and mycophenolate mofetil. a 50-year-old woman underwent lt, with her brother as the donor. she acquired hcv of serological type 1 after lt; the hc ... | 2015 | 26342292 |
| human herpes virus 8-unrelated primary effusion lymphoma-like lymphoma in the pericardium: a case with latency type iii epstein-barr virus infection showing good prognosis without chemotherapy. | primary effusion lymphoma (pel) is a rare subtype of non-hodgkin lymphoma that proliferates in body cavities without detectable masses. pel is universally associated with human herpes virus-8 (hhv-8) infection and has an aggressive prognosis. recently, an hhv-8-unrelated pel-like lymphoma that usually occurs in elderly individuals and follows a more indolent prognosis has been reported, and it is treated as a disease distinct from pel. however, its pathogenesis and prognostic factors have not be ... | 2015 | 26384578 |
| successful treatment of hcv-associated cryoglobulinemia with ombitasvir/paritaprevir/ritonavir, dasabuvir and ribavirin: a case report. | cryoglobulinemia is an important extrahepatic manifestation of chronic hepatitis c virus infection. current treatments are suboptimal, resulting in relapse or refractoriness in 30-40% of patients. hereby, we describe the case of a 40-year old man with severe hepatitis c virus-associated cryoglobulinemia, effectively treated with an interferon-free combination regimen. the patient was treated for 12 weeks with ombitasvir/paritaprevir/ritonavir, dasabuvir and ribavirin. rapid clinical and immunolo ... | 2015 | 26414149 |
| three patients treated with daclatasvir and asunaprevir for recurrent hepatitis c after liver transplantation: case report. | we previously reported our data on telaprevir or simeprevir used in combination with pegylated interferon (peg ifn) and ribavirin (rbv) for the treatment of recurrent hepatitis c virus (hcv) genotype 1 infection after liver transplantation (lt). here, we report three patients who achieved viral responses with no effect on the blood concentrations of immunosuppressive agents following daclatasvir and asunaprevir treatment. the first patient was a 57-year-old man with hcv-related liver cirrhosis w ... | 2016 | 26439054 |
| synergistic anti-tumor effects of zoledronic acid and radiotherapy against metastatic hepatocellular carcinoma. | a 72-year-old man with advanced hepatocellular carcinoma and decompensated hepatitis c virus-related cirrhosis suffered from a metastatic femoral fracture. after undergoing radiotherapy, he was only treated with supportive care, except for the administration of zoledronic acid (za). thereafter, the initially elevated serum α-fetoprotein and des-gamma carboxyprothrombin levels declined to within the normal ranges. hepatic and metastatic adrenal tumors, distant from the radiation field, exhibited ... | 2015 | 26466697 |
| spontaneous bacterial peritonitis due to methicillin-resistant staphylococcus aureus in a patient with cirrhosis: the potential role for daptomycin and review of the literature. | gram-positive cocci are emerging causes of spontaneous bacterial peritonitis (sbp), especially in patients with healthcare-associated infections. we report the case of a 68-year-old man with hepatitis c virus and alcohol-related cirrhosis who developed sbp due to methicillin-resistant staphylococcus aureus treated with daptomycin. we discuss the potential role of daptomycin in this setting with a review of the literature about the use of daptomycin in primary or secondary bacterial peritonitis. | 2015 | 26500743 |
| daclatasvir and asunaprevir for recurrent hepatitis c following living donor liver transplantation with hiv co-infection. | antiviral treatment in liver transplant recipients co-infected with hepatitis c virus (hcv) and hiv remains a challenge. we herein report a case of hcv recurrence that was successfully treated using interferon-free anti-hcv therapy with daclatasvir and asunaprevir. a 48-year-old man underwent antiviral therapy with a 24-week course of daclatasvir and asunaprevir for biopsy-proven recurrent hcv 15 months after living donor liver transplantation, following non-response to pre-emptive antiviral tre ... | 2016 | 26508337 |
| ectopic hepatocellular carcinoma arising from the peritoneum in a patient with a history of oropharyngeal cancer: a case report. | a subphrenic mass was noted on a surveillance computed tomography (ct) scan of a 65-year-old man who had achieved complete remission of oropharyngeal cancer after concurrent chemoradiotherapy. the mass was 3.2 cm in size and showed a multilobular enhancing pattern along the peritoneal lining. the patient was negative for hepatitis b surface antigen and anti-hepatitis c virus antibody. his carcinoembryonic antigen level was within the normal range. contrast-enhanced ct revealed no mass in the liv ... | 2017 | 26600779 |
| probable case of drug reaction with eosinophilia and systemic symptom syndrome due to combination therapy with daclatasvir and asunaprevir. | a 66-year-old, interferon-ineligible, treatment-naive man who was diagnosed with chronic hepatitis c due to hepatitis c virus genotype 1b began combination therapy with daclatasvir and asunaprevir. on day 14 of treatment, hepatic reserve and renal function deterioration was observed, while his transaminase levels were normal. both daclatasvir and asunaprevir were discontinued on day 18 of treatment, because the patient complained of dark urine and a rash on his trunk and four limbs. after discon ... | 2015 | 26677451 |
| liver transplant in patients with viral hepatitis and human immunodeficiency virus coinfection: the first 2 cases in turkey. | the outcomes of liver transplant in human immunodeficiency virus-infected patients are improving with advances in antiretroviral treatment. data about such cases are rare in turkey. we present the first 2 living-donor liver transplants performed in turkey in patients with viral hepatitis/human immunodeficiency virus coinfection. case 1: a 47-year-old man infected with human immunodeficiency virus with chronic hepatitis b and d and hepatocellular carcinoma within the milan criteria had been takin ... | 2016 | 26789197 |
| inflammatory pseudotumor of the liver occurring during the course of hepatitis c virus-related hepatocellular carcinoma treatment: a case report. | inflammatory pseudotumor (ipt) of the liver is a rare and benign disease that has a good prognosis. it is often difficult to distinguish ipt from hepatic malignancies, such as hepatocellular carcinoma (hcc), because specific clinical symptoms are absent and the diseases' radiological findings can be similar. ipt is particularly difficult to distinguish from hcc in livers with hepatitis c virus (hcv)-related cirrhosis. we report a case of ipt of the liver that mimicked hcv-related hcc recurrence. | 2016 | 26826935 |
| renal lymphangiectasia: a curious cause of pleural effusion. | renal lymphangiectasia is a disorder of the lymphatic system of the kidneys, which can be congenital or acquired. although the exact etiology remains unknown, an obstructive process resulting from several causes, including infection, inflammation or malignant infiltration, has been suggested to be responsible for the acquired form. this disorder may be associated with several pathologies. we report a case of a 24-year-old man with renal lymphangiectasia presenting with polycythemia, ascites and ... | 2015 | 26858768 |
| a case of peripheral t-cell lymphoma, not otherwise specified in a hcv and htlv-ii-positive patient, diagnosed by abdominal fluid cytology. | peripheral t-cell lymphoma, not otherwise specified (ptcl, nos) is a rare neoplasm that typically presents as generalized lymphadenopathy. ptcl, nos presenting as malignant ascites is rare. | 2016 | 27034820 |
| meningitis caused by candida dubliniensis in a patient with cirrhosis: a case report and review of the literature. | candida species, including candida dubliniensis, are a rare cause of meningitis. herein, we report the second case of c. dubliniensis meningitis in a 49-year-old man with a history of hepatitis c virus-related cirrhosis, substance use disorder, and recent exposure to intravenous antibiotic therapy, presenting with confusion, abnormal gait, and urinary incontinence. magnetic resonance imaging (mri) of the brain showed marked hydrocephalus and leptomeningeal enhancement. initial cerebrospinal flui ... | 2016 | 27038312 |
| osteonecrosis of the jaw during sorafenib therapy for hepatocellular carcinoma. | sorafenib is an oral multiple tyrosine kinase inhibitor and is currently the only evidence-based treatment recommended for advanced hepatocellular carcinoma. we report a case of osteonecrosis of the jaw that occurred during sorafenib therapy in a patient with advanced hepatocellular carcinoma not treated with bisphosphonates or other antiangiogenic drugs. | 2016 | 27079903 |
| transfusion management of factor v deficiency: three case reports and review of the literature. | factor v (fv) deficiency may be inherited as an autosomal recessive disease or acquired as a result of autoantibody formation, either spontaneously or secondary to exposure to bovine thrombin or medications. congenital fv deficiency has traditionally been treated with plasma transfusions. however, recent evidence has suggested that platelet (plt) transfusions may be a better alternative as fv stored within plt alpha granules has greater procoagulant potential and is released locally at sites of ... | 2016 | 27125565 |
| development of hypercalcemia in a patient receiving peginterferon alfa-2a therapy for polycythemia vera. | peginterferon alfa-2a (peg-ifn alfa-2a) is commonly used to treat hepatitis c virus infection and is also being used increasingly to treat myeloproliferative neoplasms including polycythemia vera. sarcoidosis associated with ifn therapy for treatment of hepatitis c is well described, with hypercalcemia occurring as a rare manifestation. we describe a 25-year-old man with polycythemia vera who became resistant to hydroxyurea after 6 years of treatment, requiring therapeutic phlebotomy procedures ... | 2016 | 27150448 |
| asymptomatic tuberculosis-induced ileal perforation in an hiv- infected individual; a case report. | the co-existence of acquired immune deficiency syndrome (aids) and tuberculosis is a major cause of morbidity and mortality because of a widespread organ involvement. the gastrointestinal tract is a common site for localization of opportunistic microorganisms in aids. however, surgical abdominal emergencies such as intestinal perforation resulted from tuberculosis are uncommon in these patients. the asymptomatic occurrence of such intestinal perforation has not been reported our knowledge. we re ... | 2013 | 27162854 |
| living donor liver transplantation indicated for compensated liver cirrhosis with symptomatic gallstone diseases: report of two cases. | surgical interventions for symptomatic gallstone disease could be dangerous in patients with severe comorbid conditions including liver cirrhosis. here, we report our experience of living donor liver transplantation (ldlt) indicated for two patients with liver cirrhosis complicated with gallstone diseases. | 2016 | 27215224 |
| zinc-responsive necrolytic acral erythema in a patient with psoriasis: a rare case. | necrolytic acral erythema (nae) is a recently recognized dermatosis almost exclusively associated with hepatitis c virus (hcv) infection, and closely related to zinc deficiency. we present the case of a 60-year-old man with a history of psoriasis and chronic hcv infection, who developed new lesions of nae extending from previous elephantine psoriatic plaques on bilateral lower legs. according to previous reports, resolution of nae has been successfully achieved by treatment of the underlying hcv ... | 2016 | 27272315 |
| systemic immunoglobulin light-chain amyloidosis presenting hematochezia as the initial symptom. | immunoglobulin light-chain (al) amyloidosis is characterized by the deposition of insoluble fibrils composed of immunoglobulin light chains secreted by monoclonal plasma cells. given the recent advances in the therapy of al amyloidosis, it is important to diagnose this disease as early as possible. herein, we describe the case of a 62-year-old man with hepatitis c virus (hcv)-related cirrhosis presenting with hematochezia. colonoscopy showed multiple submucosal hematomas within the region rangin ... | 2016 | 27318996 |
| efficacy of interferon in recurrent valaciclovir-refractory erythema multiforme in a patient not infected with hepatitis c virus. | recurrent erythema multiforme (em) is rare and is most typically related to infections with herpes simplex virus. prophylactic administration of valaciclovir is the first-line treatment, but there is no agreement about second-line treatment in cases of ineffectiveness. we present a 31-year-old man who was not infected with hepatitis c virus (hcv), and had a history of severe and recurrent em, unresponsive to valaciclovir, colchicine and hydroxychloroquine. the patient noticed that an intermitten ... | 2016 | 27334053 |
| successful sofosbuvir treatment with ribavirin dose reduction for chronic hepatitis c virus genotype 2 infection in a patient with ulcerative colitis: a case report. | ulcerative colitis is a lifelong, immunologically mediated disease. direct-acting antivirals (daas) are now available for the treatment of chronic hepatitis c virus (hcv) infection. an interferon-free regimen appears useful, safe and effective for many patients for whom interferon-based treatment is contraindicated. | 2016 | 27401874 |
| orbital pseudotumor as a rare extrahepatic manifestation of hepatitis c infection. | hepatitis c is frequently accompanied by immune-related extrahepatic manifestations affecting the skin, kidneys, central and peripheral nervous system and exocrine glands. we present the case of a 40-year-old man with left-sided ptosis, exophthalmos and headache. mri demonstrated left-sided orbital pseudotumor with lacrimal and retro-orbital contrast enhancement extending to the cavernous sinus and the vestibulocochlear nerve. immunological tests of serum and cerebrospinal fluid identified hepat ... | 2016 | 27403111 |
| first next-generation sequencing full-genome characterization of a hepatitis c virus genotype 7 divergent subtype. | we report the near-full-length genome sequence of a hepatitis c virus (hcv) isolate from a man originating from democratic republic of congo, the genotype of which could not be determined by the routinely used sequencing technique. the near-complete genome sequence of this variant bak1 was obtained by the association of two next-generation sequencing technologies. evolutionary analysis indicates that this isolate, bak1, could be the first reported strain belonging to a new hcv-7b subtype. this n ... | 2016 | 27515394 |
| progressive multifocal leukoencephalopathy in a hiv negative, immunocompetent patient. | progressive multifocal leukoencephalopathy (pml) is a rare demyelinating disease most common in immunodeficient patients. it occurs due to reactivation of the john cunningham virus (jcv) and carries a poor prognosis, with a median life expectancy of 6 months. we report a case of a 66-year-old man with a history of hcv related cirrhosis (hcv) and hepatocellular carcinoma (hcc) who was found to have pml in the setting of a negative viral load in the csf and a cd4+ >200. he initially presented with ... | 2016 | 27529042 |
| double primary hepatic cancer (hepatocellular carcinoma and intrahepatic cholangiocarcinoma) originating from hepatic progenitor cell: a case report and review of the literature. | synchronous development of primary hepatocellular carcinoma (hcc) and intrahepatic cholangiocarcinoma (icc) in different sites of the liver have rarely been reported before. the purpose of this study is to investigate the clinicopathological characteristics of synchronous double cancer of hcc and icc. | 2016 | 27535234 |
| fibrosing cholestatic hepatitis in a complicated case of an adult recipient after liver transplantation: diagnostic findings and therapeutic dilemma. | background hepatitis c recurrence is a serious matter after liver transplantation (lt). approximately 10% of hepatitis c virus (hcv) positive recipients develop fibrosing cholestatic hepatitis (fch). fch rapidly results in graft loss. currently, direct-acting antivirals (daas) are effective and safe for hepatitis c, even after lt. however, only a few cases of successfully treated fch after lt have been reported. we present fch in a complicated case with sepsis and portal flow obstruction after l ... | 2016 | 27545580 |
| epidemiological profile and risk factors of hiv and hbv/hcv co-infection in fujian province, southeastern china. | this study aimed to investigate the epidemiological features of hiv-infected subjects co-infected with hbv/hcv in fujian province, southeastern china, and identify the risk factors. blood samples were collected from 2,028 hiv antibody-positive subjects in fujian province. serum hbsag and anti-hcv antibody were detected, and cd4(+) t cell count was measured. of the 2,028 subjects, the prevalence of hiv-hbv, hiv-hcv, and hiv-hbv-hcv co-infections was 16.22%, 3.7%, and 0.79%, respectively. man (or ... | 2017 | 27552721 |
| an interesting case of lucio phenomenon triggered by activation of hepatitis c infection. | lucio phenomenon (lp) or erythema necroticans is a rare type of reaction pattern found in untreated patients with diffuse non-nodular leprosy. it is important to distinguish this from vasculonecrotic erythema nodosum because thalidomide with high-dose steroids is the mainstay of treatment for the latter, whereas lp shows no response to thalidomide. we report a case of a 60-year-old man who presented with purpuric patches, hemorrhagic blisters, and ulcers over extremities of 15 days duration. on ... | 2017 | 27730040 |
| first case in kazakhstan of successful therapy with 2 consecutive direct-acting antiviral regimens in a patient with hepatitis c virus-induced decompensated liver cirrhosis on a liver transplant wait list. | a 40-year-old man, diagnosed with decompensated liver cirrhosis because of hepatitis c virus, was on the wait list for a liver transplant when he began treatment with the direct-acting antivirals simeprevir 150 mg and sofosbuvir 400 mg. the patient demonstrated end of treatment virologic response at week 12, normal bilirubin, and alanine aminotransferase levels, resolution of ascites, with downgrading to subcompensated liver cirrhosis, and was removed from the liver transplant wait list. however ... | 2016 | 27805527 |
| [surgical treatment of right atrial malignant tumor thrombus under deep hypothermia with intermittent circulatory arrest;report of two cases]. | right atrial tumor thrombus is rare in patients with visceral malignant tumors and can cause right heart failure or sudden death. we present 2 cases of right atrial tumor thrombus treated under deep hypothermic intermittent circulatory arrest (dhica). a 45-year-old man with right heart failure was diagnosed with right renal cancer extending to the right atrium. computed tomography revealed no metastasis. he underwent right nephrectomy and tumor thrombus resection under dhica. he was discharged o ... | 2016 | 27909278 |
| sofosbuvir monotherapy for asymptomatic and noncirrhotic hepatitis c infection in a renal retransplantation recipient: a case report. | renal transplant recipients infected with hepatitis c virus (hcv) have a high risk of progressing to cirrhosis, end-stage liver diseases, and hepatocellular carcinoma. it is also considered as an independent risk for graft loss and is correlated with proteinuria, transplant glomerulopathy, hcv-associated glomerulonephritis, and chronic rejection. previous therapy involving interferon alfa and ribavirin led to treatment complications, including toxicity, anemia, sepsis, and drug-drug interactions ... | 2016 | 27932161 |
| recovery after critical illness polyneuropathy in a patient with orthotopic liver transplantation: a case report. | after liver transplantation, some patients show neuromuscular abnormalities. a 43-year-old man with liver cirrhosis due to hepatitis c virus underwent living-donor liver transplantation. he developed severe neuromuscular dysfunction after sepsis, and acute respiratory distress syndrome. after the inflammatory reaction gradually improved, we observed bilateral weakness of the extremities and foot drop. electrophysiological studies indicated primary axonal degeneration of peripheral motor and sens ... | 2016 | 27932182 |
| complete necrosis of hepatocellular carcinoma after preoperative portal vein embolization: a case report. | hepatocellular carcinoma has a poor prognosis; few patients can undergo surgical curative treatment according to barcelona clinic liver cancer guidelines. progress in surgical techniques has led to operations for more patients outside these guidelines. our case shows a patient with intermediate stage hepatocellular carcinoma presenting a good outcome after curative treatment. | 2017 | 28049508 |
| successful treatment of donor-derived hepatitis c viral infection in three transplant recipients from a donor at increased risk for bloodborne pathogens. | we report here the successful treatment of hepatitis c virus (hcv) transmitted from a nucleic acid testing (nat)-negative donor to three hcv-negative recipients-two renal transplants and one liver. both renal recipients underwent standard deceased-donor renal transplantation with immediate graft function. the liver recipient underwent standard orthotopic liver transplantation and recovered uneventfully. the donor was a 39-year-old woman with a terminal serum creatinine of 0.7 mg/dl. she was high ... | 2017 | 28060446 |
| the risk of hepatocellular carcinoma after directly acting antivirals for hepatitis c virus treatment in liver transplanted patients: is it real? | since directly acting antivirals (daas) for treatment of hepatitis c virus (hcv) were introduced, conflicting data emerged about the risk of hepatocellular carcinoma (hcc) after interferon (ifn)-free treatments. we present a case of recurrent, extra-hepatic hcc in a liver-transplanted patient soon after successful treatment with daas, along with a short review of literature. | 2016 | 28070200 |
| unusual presentation; seeding of tumor after biopsy for hepatocellular carcinoma. | hepatocellular cancer is one of the most common and fatal cancer tumor worldwide. however, the obtained results are questionable in terms of medical treatment of hepatocellular cancer. the muscle, soft tissue and cutaneous metastases of hepatocellular cancer, for instance, are rare and may result from interventional procedures. seeding of tumor along the biopsy needle upon percutaneous biopsy is a very rare phenomenon. we report a very rare case of a 79 -year- old man, known to be hepatitis c vi ... | 2017 | 28083068 |
| isolated bilateral tapia's syndrome after liver transplantation: a case report and review of the literature. | to describe one case of bilateral tapia's syndrome in a liver transplanted patient and to review the literature. | 2016 | 28083087 |
| sofosbuvir in the treatment of early hcv infection in hiv-infected men. | there is an international epidemic of hepatitis c virus (hcv) infection among hiv-infected men who have sex with men. we previously showed that adding telaprevir to pegylated interferon (ifn) and ribavirin (rbv) both shortened treatment and increased the cure rate of early hcv in these men. whether shortening treatment of early hcv using ifn-free regimens would be similarly successful has not yet been demonstrated. | 2017 | 28183221 |
| [spontaneous remission of hcv infection after autologous stem cell transplantation in a 58-year-old man]. | we report about a 58-year-old man with a chronic and treatment-naive hepatitis c virus (hcv) infection of genotype 1b, who had undergone autologous stem cell transplantation twice due to multiple myeloma. subsequently, a high-level viremic reactivation of an occult hepatitis b virus (hbv) infection and also a reverse seroconversion was observed. furthermore, a sustained spontaneous remission of hcv infection was seen. antiviral therapy of hbv infection was initiated with tenofovir. seven months ... | 2017 | 28235985 |
| a wolf in another wolf's clothing. | this case of infective endocarditis masquerading as mixed cryoglobulinemia in a man with a history of intravenous drug use (ivdu) and hepatitis c virus (hcv) highlights the importance of maintaining a broad differential and continually re-evaluating the working diagnosis as new information presents itself. the patient presented to an outside hospital and was treated for presumptive mixed cryoglobulinemia with corticosteroid therapy. when the patient did not improve, he was transferred to a terti ... | 2017 | 28289605 |
| lusutrombopag increases hematocytes in a compensated liver cirrhosis patient. | a 56-year-old japanese man with liver cirrhosis (lc) due to hepatitis c virus was admitted to our hospital for radiofrequency ablation of residual tumor following lusutrombopag administration. laboratory tests revealed thrombocytopenia and leukopenia. the patient's lc was managed, and he was classified as child-pugh a. after admission, lusutrombopag was administered for 7 days. the platelet count increased to over 50,000/mm(3) after 7-14 days and returned to previous levels 50 days after adminis ... | 2017 | 28324272 |
| novel application of extracorporeal photopheresis as treatment of graft-versus-host disease following liver transplantation. | a 48-year-old man with hepatitis c virus (hcv) cirrhosis complicated by hepatocellular carcinoma underwent liver transplantation. his course was complicated by fever, diarrhea, abdominal pain, and pancytopenia. he developed a diffuse erythematous rash, which progressed to erythroderma. biopsies of the colon and skin were consistent with acute graft-versus-host disease. donor-derived lymphocytes were present in the peripheral blood. the patient was treated with corticosteroids and cyclosporine; h ... | 2017 | 28377936 |
| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |