Publications

2,4-dichlorophenoxyacetic acid (2,4-d) does not cause polyneuropathy in the rat.	2,4-dichlorophenoxyacetic acid (2,4-d), a component of agent orange, was injected intraperitoneally into adult male fisher rats for 3-12 weeks. during the period of study gait and toe-spreading reflexes remained normal and distal motor latencies, motor and mixed nerve conduction velocities and amplitudes remained similar (p greater than 0.05) in animals receiving 2,4-d or vehicle. this study suggests that 2,4-d is not toxic to peripheral nerves in the rat.	1985	2997403
selective inhibition of leukotriene b4 biosynthesis in rat pulmonary alveolar macrophages by dietary selenium deficiency.	weanling male fisher 344 rats were maintained on low selenium basal and se-supplemented diets for 38 weeks. a several fold reduction in the glutathione peroxidase activity of the lung and liver tissues in rats maintained on low se basal diet established their se-deficient status. analysis of the supernatants from resting pulmonary alveolar macrophage suspensions showed negligible extracellular release of pge2, txb2 and ltb4 in both diet groups. a challenge with opsonized zymosan particles increa ...	1985	2998361
regulation of na,k-atpase biosynthesis in developing artemia salina.	regulation of the biosynthesis of the sodium- and potassium-activated adenosine triphosphatase (na,k-atpase) (ec 3.6.1.3) was studied in the developing brine shrimp, artemia salina. measurement of levels of the subunits of the na,k-atpase by radioimmunoassay indicated the presence of both alpha and beta subunits in undeveloped cysts and developing embryos prior to the appearance of enzymatic activity. the quantity of each subunit increased dramatically between 8 and 24 h of development and then ...	1986	3001068
effect of age on beta adrenergic relaxation of the rat jugular vein.	using the fisher 344 rat model and blood vessel ring segments in vitro, age-related changes in vascular beta adrenergic relaxation were investigated. in the pulmonary artery and aorta, maximum isoproterenol-induced relaxation and sensitivity to isoproterenol declined from 1 to 3 months of age confirming previous reports. in animals 6 months of age, these vessels no longer relaxed to isoproterenol. in the jugular vein, in which beta adrenergic mechanisms predominate, there was no change in maximu ...	1986	3001294
morphine dependence and protracted abstinence: regional alterations in cns radioligand binding.	rats (fisher f-344) were given free access to a 10% sucrose solution containing 0.5 mg/ml morphine sulfate (controls received the sucrose vehicle only) as their sole source of fluid. daily morphine intake averaged 119 +/- 21 mg/kg, an amount sufficient to induce physical dependence. after 18 days on this regimen, the control and dependent subjects were sacrificed. a protracted abstinence group was weaned from morphine by reducing its concentration in the vehicle by 20% over the next 5 days, foll ...	1985	3001786
polyomavirus-transformed fr 3t3 rat cells are able to form metastases in syngeneic rats.	a series of polyomavirus-transformed fr 3t3 rat cell lines were tested for their tumorigenic and metastatic properties after subcutaneous inoculation of syngeneic fisher rats. all of them grew into tumors, which appeared with variable latency periods; the td50 varied from cell line to cell line. eight of the 18 transformants that were inoculated gave rise to metastases, always localized in the lung. the capacity to form metastases, though at a low frequency, was also conferred on fr 3t3 cells up ...	1986	3002027
short- and long-term evaluation of normal and abnormal human thyroid cells in monolayer culture.	we have investigated the tsh responsiveness of normal and abnormal human thyroid cells cultured in the short term with high serum concentrations and for up to 6 months in a low serum, chemically-defined, medium. cells from normal human thyroid tissue (n = 9), multinodular goitre (n = 6), benign follicular adenomata (n = 6), and differentiated thyroid carcinoma (n = 3) formed confluent monolayers which were sensitive to bovine tsh (btsh) in concentrations greater than 25 microu/ml when assessed b ...	1985	3002667
control of phosphorylase kinase in the isolated glycogen particle by ca2+-mg2+ synergistic activation and camp-dependent phosphorylation.	the isolated glycogen particle provides a means to examine the regulation of glycogen metabolism with the components organized in a functional cellular complex. with this system, we have studied the control of phosphorylase kinase activation by ca2+ and camp. contrary to a previous report (heilmeyer, l. m. g., jr., meyer, f., haschke, r. h., and fisher, e. h. (1980) j. biol. chem. 245, 6649-6656), phosphorylase kinase became activated during incubation of the glycogen particle with mgatp2- and c ...	1986	3007504
hcg-induced tsh receptor activation and growth acceleration in frtl-5 thyroid cells.	our previous studies have indicated specificity cross-over between lh/hcg and the tsh receptor. we have now analyzed the ability of the tsh-dependent fisher rat thyroid cell line (frtl-5) to proliferate in a differentiated state under the influence of highly purified hcg (hcg-cr121). tsh receptor activation and growth induction were observed after 7 days suspension from a tsh-induced growth phase. the effect of 10 ug hcg-cr121 was equivalent to 500 +/- 43 (mean +/- sem) uiu of human tsh (2nd irp ...	1986	3009152
human immunodeficiency virus seroprevalence in pediatric patients 2 to 14 years of age at mama yemo hospital, kinshasa, zaire.	seroprevalence to human immunodeficiency virus (hiv) was determined among 368 children 2 to 14 years of age who were admitted to the pediatric service at mama yemo hospital in kinshasa, zaire. forty (11%) of these patients and only one (1%) of 92 healthy siblings of these patients were hiv seropositive (chi 2 = 8.68, p less than .01). seropositivity was associated with previous hospitalization, receipt of a blood transfusion prior to the current hospitalization (odds ratio 3.1; 95% confidence in ...	1986	3020492
foodborne snow mountain agent gastroenteritis in a school cafeteria.	in 1984, an outbreak of gastroenteritis occurred at a school with 1,860 students in brooklyn, ny. in a single-stage cluster sample of 375 students, 129 (34%) had illnesses that met our case definition of vomiting or diarrhea. the mean incubation period was 26 hours, and the mean illness duration was 24 hours. all case students had eaten in the cafeteria on at least one day between nov 13 and 16, compared with 174/214 (81%) noncase students (p = 10(-8), fisher exact test). foods implicated were f ...	1987	3029660
protection from ischemia-induced cerebral edema in the rat by u-50488h, a kappa opioid receptor agonist.	u-50488 is a specific kappa opioid agonist which produces in rats water diuresis resulting in an elevation of plasma osmolarity. pretreatment with u-50488h (the methanesulfonate salt) in fisher rats prior to 4 h of bilateral carotid occlusion prevented the development of edema in the forebrain, and the effect was greater than that from pentobarbital anesthesia. an additional injection of an antidiuretic hormone which prevented the plasma hyperosmolarity also significantly reduced the anticerebra ...	1987	3030502
cellular mutation mediates t-antigen-positive revertant cells resistant to simian virus 40 transformation but not to retransformation by polyomavirus and adenovirus type 2.	t-antigen-positive transformation revertant cell lines were isolated from fully simian virus 40 (sv40)-transformed fisher rat embryo fibroblast cells (ref 52 cells) by methionine starvation. reversion of the transformed cells (sv-52 cells) was caused by a mutation within the cellular genome. to demonstrate this, we isolated sv40 dna from the host genome, inserted it into plasmid pspt18 dna, cloned it in escherichia coli, and microinjected it into the nuclei of the ref 52 cells. fully transformed ...	1987	3033314
cloning the fisher rat thyroid cell line (frtl-5): variability in clonal growth and 3,'5'-cyclic adenosine monophosphate response to thyrotropin.	to investigate the stability of frtl-5 cells we cloned stock cells by limiting dilution in a 6-hormone medium with bovine tsh (btsh) (10 mu/ml) (6h medium). one third of the wells with irradiated fibroblast feeder cells developed frtl-5 colonies. one hundred and twenty clones were obtained, of which 29 (8%) developed sufficiently for functional analysis. clones were tested for growth responses to btsh stimulation as evidenced by 72-h [3h]thymidine uptake and tsh receptor activation by camp gener ...	1987	3036476
age-dependent changes in rat brain mitochondria of synaptic and non-synaptic origins.	synaptic and non-synaptic mitochondria were isolated from the brains of 3- 12-and 28-30-month-old female fisher 344 rats. total oxygen consumption and oxygen consumption due to mitochondrial respiration decreases 83% with increasing age in synaptic mitochondria using malate plus glutamate as substrate, but only 33% in non-synaptic mitochondria; succinate-driven activity is not affected. succinate-driven superoxide generation decreases over 90% in both fractions; malate plus glutamate-driven supe ...	1987	3037204
on the fidelity of dna replication. isolation of high fidelity dna polymerase-primase complexes by immunoaffinity chromatography.	error rates for conventionally purified dna polymerase-alpha from calf thymus, chicken, and human sources have been reported to be one in 10,000 to one in 40,000 nucleotides incorporated. isolation of polymerase-alpha by immunoaffinity chromatography yields a multiprotein high molecular weight replication complex that contains an associated dna primase (wong, s. w., paborsky, l. r., fisher, p. a., wang, t. s-f., and korn, d. (1986) j. biol. chem. 261, 7958-7968). we have isolated dna polymerase- ...	1987	3038898
perioperative and late outcome in patients with left ventricular ejection fraction of 35% or less who require major vascular surgery.	survival in patients with diminished left ventricular ejection fraction (ef) is reduced after major vascular surgery. the objective of this study was to determine perioperative (30-day) and subsequent outcome after major vascular surgery in those with severe cardiac dysfunction, defined by ef being 35% or less (normal ef greater than 50%). from aug. 1, 1984 to jan. 1, 1988, 35 patients with ef equal to 27.7% +/- 6.1% (mean +/- 1 standard deviation) have required 47 major vascular procedures: 53% ...	1988	3047443
programs for pedigree analysis: mendel, fisher, and dgene.		2011	3061869
review of fisher.		2011	3061870
relationship between in vivo airway reactivity and in vitro responsiveness of tracheal smooth muscle in inbred rats.	we evaluated the in vivo and in vitro airway responses to cholinergic stimulation in two highly inbred strains of rats. five fisher and six lewis rats inhaled aerosols of doubling concentrations of methacholine (mch). pulmonary resistance (rl) was measured before and after each mch inhalation. the concentration of mch required to double rl (ec200rl mch) was calculated. spirally cut tracheal strips were suspended in an organ bath and the isometric tension was recorded. cumulative concentration-re ...	1988	3068743
a tribute to the late russell s. fisher.		2011	3071135
pre- and postsynaptic markers of cholinergic neurons in the cerebral cortex of rats of different ages.	in order to investigate the effect of aging on postsynaptic muscarinic binding, we measured 3h-pz binding in the cerebral cortex of male fisher 344 rats of different ages. chat activity was measured as a presynaptic marker of the cholinergic system. total and salt-soluble ache activities were also measured. maximal binding of 3h-pz and chat activity did not change during aging. the ratio of detergent-soluble ache to salt-soluble ache was lower in 30-month-old rats than in 4-month-old rats. the r ...	1988	3074925
in vitro and in vivo regulation of liver epithelial cells carrying a metallothionein-rast24 fusion gene.	we inserted a zinc-responsive metallothionein-rast24 fusion gene in both orientations into a retroviral vector (svx) and infected fisher rat liver epithelial cells. only the construction in which the viral long terminal repeat and the metallothionein promoters were in opposite orientations resulted in cell lines with biologically altered behavior. two lines (mtr-1 and mtr-6) showed altered morphology in vitro when znso4 was added to the medium. these cell lines grew in soft agarose in a dose-dep ...	1988	3076453
structural analysis and immunogenicity of pseudomonas aeruginosa immunotype 2 high molecular weight polysaccharide.	we analyzed high molecular weight polysaccharide (ps) from the fisher immunotype 2 (it-2) strain of pseudomonas aeruginosa for molecular composition and structure, then determined its immunogenicity in healthy adults. the ps was composed of 2-acetamido-2,6-dideoxygalactose (n-acetyl fucosamine) and glucose in a molar ratio of 2:1. structural analysis by carbon-13 and proton nuclear magnetic resonance confirmed that the high molecular weight ps was structurally identical to that of the o-specific ...	1986	3080477
adherent spleen cell production of e series prostaglandins in rats bearing variants of the r3327 dunning prostatic adenocarcinoma: effect of cyclophosphamide.	prostaglandins of the e series (pge) have been implicated in many facets of immunoregulation, as well as having a possible role in metastatic dissemination. variant sublines of the dunning r3327 rat prostatic adenocarcinoma, differing in growth rate, hormonal responsiveness and in propensity for metastasis, were carried in fisher x copenhagen f1 animals. adherent spleen cells were assayed in vitro for their ability to convert arachidonic acid to prostaglandins of the e series. these glass adhere ...	1986	3088126
[ir-gene control of rat t-lymphocyte proliferation in response to ig allotype].	antigen-induced t-cell proliferation in vitro was adapted to the estimation of antiallotypic response to igk-ib immunoglobulin k chain allotype of msu/b and fisher rats in wag, august and fi (wag x august) rats. august and fi rat t lymphocytes responded to igk-ib alloantigen with stimulation indexes (si) 3.8-5.0 (high responders), while wag rat t lymphocytes showed practically no response (si 0.9-1.8--low responders). these results correlate well with our previous findings of ir-gene-controlled ...	1986	3089344
polyclonal and monoclonal antibody therapy for experimental pseudomonas aeruginosa pneumonia.	a human immunoglobulin g preparation, enriched in antibodies to lipopolysaccharide (lps) pseudomonas aeruginosa antigens (pa-igiv) and murine monoclonal antibodies (mab) to p. aeruginosa fisher immunotype-1 (it-1) lps antigen and outer membrane protein f (porin), were evaluated for therapeutic efficacy in a guinea pig model of p. aeruginosa pneumonia. the concentration of antibodies to it-1 lps was 7.6 micrograms/ml in pa-igiv and 478 micrograms/ml in the it-1 mab preparation. no antibody to it- ...	1986	3093385
influence of complex charge and size on the uptake of 99mtc-diphosphonates in osteogenic tissue.	the biodistributions of six chromatographically pure 99mtc-hedp complexes have been determined in soft tissues, normal bone and osteogenic lesions (induced with a walker 256 tumor) in fisher 344 rats. the physical properties of each 99mtc-hedp complex including anionic charge, partial molar volume, molecular weight and spectral characteristics are known; thus allowing structure-activity relationships to be drawn. the results indicate that the smallest, low charged, mononuclear 99mtc-hedp complex ...	1986	3095270
cross-reactions of lipopolysaccharides of pseudomonas aeruginosa in antipneumococcal and other antisera.	lipopolysaccharides of the seven fisher immunotypes of pseudomonas aeruginosa gave cross-precipitation in many antipneumococcal sera. the reaction of pseudomonas type iv in type 25 antipneumococcal serum was immediate and heavy: 93 micrograms of antibody nitrogen per ml. correlations are described, mainly between the structures of the o-chains of the immunotypes and their specificities as shown by the cross-reactions.	1986	3096896
the mobility of concanavalin a receptors and surface immunoglobulins on rat hepatocyte plasma membranes.	lateral mobilities of lectin receptors and surface immunoglobulins were measured in plasma membranes of hepatocytes prepared by smearing small pieces of rat liver tissue and then using the fluorescence recovery after photobleaching (frap) technique. smears were treated with various doses of fluorescein isothiocyanate (fitc) conjugated concanavalin a (cona), succinylated cona (scona), wheat germ agglutinin (wga), and soybean agglutinin (sba), as well as with rabbit anti-rat igg (rara/igg) and goa ...	1987	3098295
reduction of local tumor recurrence by excision with the co2 laser.	this study was undertaken to determine the effect of co2 laser surgery on the incidence of local recurrence following tumor resection. thirty female fisher 344 rats were implanted with r3230ac mammary carcinoma. all tumors were completely excised 18-21 days post-implantation. in 15 animals, the resection was done with a scalpel. fifteen animals underwent laser excision with the sharplan 733 co2 laser (temoo, 125 mm handpiece, 25w continuous wave). primary tumor size was 17.6 +/- 1.4 mm in the sc ...	1986	3100889
the use of monoclonal antibodies in the diagnosis of partially treated pseudomonas aeruginosa meningitis: patient report.	the objective of this study was to evaluate the efficacy of mouse anti-pseudomonas monoclonal antibodies to detect small numbers of pathogenic pseudomonas in the spinal fluid of a patient who had been treated with antibiotics for meningitis. anti-605 monoclonal antibody against pseudomonas aeruginosa pac 605, a rough mutant, showed sensitivity similar to that of anti-fisher 1 monoclonal antibody in detecting p. aeruginosa fisher 1 antigens in boiled spinal fluid drawn from a patient with a p. ae ...	1986	3103793
somatic antigens of pseudomonas aeruginosa. the structure of o-specific polysaccharide chains of the lipopolysaccharides from p. aeruginosa o5 (lányi) and immunotype 6 (fisher).	lipopolysaccharides were isolated from dry bacterial cells of pseudomonas aeruginosa o5a,b,c, o5a,b,d, o5a,d (lányi classification) and immunotype 6 (fisher classification) by the westphal procedure. their polysaccharide chains were built up of trisaccharide repeating units containing d-xylose, 2-acetamido-2,6-dideoxy-d-galactose and a new sialic acid-like sugar, the di-n-acyl derivative of 5,7-diamino-3,5,7,9-tetradeoxy-l-glycero-l-manno-nonulosonic (pseudaminic) acid. formyl, acetyl and (r)-3- ...	1987	3104041
[prevention using a pseudomonas immunoglobulin in burn patients].	pseudomonas aeruginosa belongs to the most frequent pathogens isolated from patients with burns. in a mouse model for artificial burns it was found that prophylactic administration of a hyperimmune globulin with antibody titres against p. aeruginosa (fisher immunotypes 1, 2, 4 and 6) reduced mortality. therefore, the prophylactic administration of pseudomonas immunoglobulin was examined in a prospective randomized study in two groups of 13 patients each. severely burned patients with at least se ...	1987	3106234
production of cytotoxin by clinical strains of pseudomonas aeruginosa.	presence of cytotoxin was studied in extracts of 57 strains of pseudomonas aeruginosa (46 bacteremia, 4 environmental, and 7 fisher immunotype), 10 pseudomonas species, and 7 nonpseudomonas isolates. cytotoxin was identified by western immunoblot in extracts of all p. aeruginosa isolates. none of the pseudomonas species or nonpseudomonas isolates were shown to produce this protein. no immunologic cross-reactivity was observed between cytotoxin antibody and p. aeruginosa alkaline protease, toxin ...	1987	3107788
comparison of the chinese schema and the international antigenic typing system for serotyping pseudomonas aeruginosa.	twelve strains of pseudomonas aeruginosa representing 12 serogroups in the serogrouping schema used in the people's republic of china were compared with serogroups in the international antigenic typing system (iats). the first eight groups originated in the people's republic of china, and group ii appears to have a new major antigen that is not found in the iats. groups i, iii, iv, v, vi, vii, and viii correspond to groups 11, 6, 9, 4, 8, 3, and 1, respectively, of the iats. groups ix, x, xi, an ...	1987	3108310
[pseudomonas immunoglobulin prophylaxis in patients with burn injuries].	pseudomonas aeruginosa belongs to the most frequent pathogens isolated from patients with burns. in a mouse model for artificial burns it was found that prophylactic administration of a hyperimmune globulin with antibody titres against p. aeruginosa (fisher immunotypes 1, 2, 4 and 6) reduced mortality. therefore, the prophylactic administration of pseudomonas immunoglobulin was examined in a prospective randomized study in two groups of 13 patients each. severely burned patients with at least se ...	1987	3112025
dose requirements, assay procedures and tissue specificity for pcb inductation of p-450 dependent mono-oxygenase activity in the rat: implications for design of studies measuring in vivo induction of human placental mono-oxygenases.	pregnant sprague-dawley and fisher 344 rats were treated on day 15 of gestation with aroclor 1254 in a single dose ranging from 0 to 500 mg kg-1 body weight and killed on day 18 of gestation. in the small groups of animals used for this study, no effect was observed on mean maternal liver or placental weight, or the number of fetal resorptions at any of the doses tested. measurement of aryl hydrocarbon hydroxylase (ahh) and 7-ethoxycoumarin o-deethylase (7ecd) activity in tissue homogenates, how ...	1987	3114357
the role of humoral immunity in lactobacillus casei cell wall induced arthritis.	although both cellular and humoral immunity have been shown to play important roles in the development of collagen induced arthritis, their roles in the pathogenesis of bacterial cell wall induced arthritis remain unclear. previous studies of humoral immunity in bacterial cell wall induced arthritis were carried out in outbred animals and measured the humoral response to only the eliciting bacteria. we compared the humoral immune responses of arthritis susceptible lewis and arthritis resistant f ...	1987	3114482
somatic antigens of pseudomonas aeruginosa. the structure of o-specific polysaccharide chains of lipopolysaccharides of p. aeruginosa o3 (lányi), o25 (wokatsch) and fisher immunotypes 3 and 7.	o-specific polysaccharides, obtained on mild acid degradation of lipopolysacchrides of the serologically related strains pseudomonas aeruginosa o3 (lányi classification), o25 (wokatsch classification) and immunotypes 3 and 7 (fisher classification), are built up of trisaccharide repeating units involving 2-acetamido-2,6-dideoxy-d-galactose (n-acetyl-d-fucosamine), 2,3-diacetamido-2,3-dideoxy-d-mannuronic acid or 2,3-diacetamido-2,3-dideoxy-l-guluronic acid and 3-acetamidino-2-acetamido-2,3-dideo ...	1987	3115777
a new approach to monoclonal antibody production. in vitro immunization with antigens on nitrocellulose using drosophila myosin heavy chain as an example.	a methodology of broad applicability is described for the production of monoclonal antibodies to antigens with interesting developmental properties using drosophila myosin heavy chain to exemplify the procedure. the technique consists of two parts. (1) identification of the antigen with any tool which allows its detection on a western blot. in the present case, this was achieved by monospecific polyclonal antibodies, prepared as described by smith and fisher (j. cell biol. (1984) 99, 20), which ...	1987	3117889
hemagglutination patterns of pseudomonas aeruginosa strains of different serogroups, habs and fisher types.	pseudomonas aeruginosa strains of sixteen habs and three fisher types were examined for their hemagglutination activity using vertebrate erythrocytes including human ones. their carbohydrate-binding specificity as determined by hemagglutination-inhibition suggests a possible method of their purification. this study also indicates the possibility of an occurrence of multiple lectins of different specificity.	1987	3118598
induction of rat thyroid cell mhc class ii antigen by thyrotropin and gamma-interferon.	major histocompatibility (mhc) class ii antigen expression by thyroid epithelial cells has been widely implicated in the pathogenesis of autoimmune thyroid disease. we have examined rat mhc (rt1) class ii antigen gene regulation in 1b-6 cells, cloned in our laboratory from the fisher rat thyroid line frt-l5. 1b-6 cells are tsh dependent for growth and proliferation, and are responsive to more than 5 microu/ml bovine tsh (btsh) in terms of extracellular camp accumulation. recombinant rat gamma in ...	1987	3119313
characterization of proteoglycans synthesized by rat thyroid cells in culture and their response to thyroid-stimulating hormone.	a fisher rat thyroid cell line was maintained in culture and the cells were labeled with [3h]glucosamine, [35s]sulfate, and [35s]cysteine to examine the synthesis of proteoglycans. 3h and 35s radioactivity from these precursors were incorporated into both chondroitin sulfate (cs) and heparan sulfate (hs) proteoglycans. cs proteoglycans were almost exclusively secreted into the medium while hs proteoglycans remained mainly associated with the cell layer. single chain glycosaminoglycans released b ...	1988	3123476
the intestinal zinc transport in aged rats.	to determine if there are any age-related alterations in the intestinal zinc absorption that may contribute to zinc deficiency, we studied the zinc transport across the jejunal segments of 3-, 12- and 24-month-old fisher 344 male rats using the ussing chamber technique. we also evaluated the effect of 5 microm arachidonic acid in tissue bathing media. the zinc transport from mucosa to serosa in 24-month-old rats (55.0 +/- 3.5 nmol/h/cm2) was significantly greater than the transport in 12-month-o ...	1987	3123812
enhancement of udp-glucuronyltransferase, udp-glucose dehydrogenase, and glutathione s-transferase activities in rat liver by dietary administration of eugenol.	male fisher rats were fed a diet ad lib. containing eugenol (4-allyl-2-methoxyphenol) to observe its effects on liver drug-detoxifying enzymes such as udp-glucuronyltransferase (gt), udp-glucose dehydrogenase (dh) and glutathione s-transferase (gst). liver weights were not affected significantly by a diet containing 3% eugenol (w/w) for 13 weeks. the activities of gt of liver microsomes toward various xenobiotic substances such as 4-nitrophenol, 1-naphthol, 4-hydroxybiphenyl and 4-methylumbellif ...	1988	3125837
x-linked immunodeficient mice as a model for testing the protective efficacy of monoclonal antibodies against pseudomonas aeruginosa.	(dba/n[female] x cba/2[male])f1 males have been reported to be deficient in producing antibodies against a number of antigens, including carbohydrates (i. scher, adv. immunol. 35:1-71, 1982). we show that f1 male mice, in contrast to females, made less lipopolysaccharide (lps)-specific antibodies after immunization with heat-inactivated pseudomonas aeruginosa and had significantly less naturally occurring lps-specific antibodies. furthermore, neutropenic males were 50 to 1,000 times more sensiti ...	1988	3128480
aurothioglucose effect on sulfhydryls and glutathione-metabolizing enzymes: in vivo inhibition of selenium-dependent glutathione peroxidase.	fisher 344 rats injected with a total of 20.8 +/- 1.5 mg of gold (au) as aurothioglucose over an 8-wk period were used to study the effect of long-term au treatment on selenium-dependent glutathione peroxidase (segshpx), other enzymes related to gsh metabolism, gsh, nonprotein sulfhydryls, and total sulfhydryls (sh) in various tissues. the indirect coupled assay for segshpx revealed decreased activity in platelets of au-treated rats but not in other tissues. inhibition of segshpx by au is revers ...	1988	3128851
r. a. fisher and the 0.05 level of significance in medical studies.		1988	3129528
specific and nonspecific imaging of localized fisher immunotype 1 pseudomonas aeruginosa infection with radiolabeled monoclonal antibody.	to determine if radiolabeled specific antibodies directed against bacterial antigens could be used to detect sites of infection, gamma camera imaging studies were performed in animals infected with pseudomonas aeruginosa. murine monoclonal antibodies (mabs) directed against fisher immunotype 1 pseudomonas aeruginosa and a nonmicrobial, nonmammalian haptene, p-arsanilic acid, were labeled with 125i by the lodogen-bead method. unilateral, deep thigh infections were created by innoculation with 2 x ...	1988	3131499
use of l-glutamine in total parenteral nutrition.	gut atrophy develops during prolonged total parenteral nutrition (tpn). tpn solutions do not contain glutamine, an energy substrate of the intestinal tract. this study evaluated the effect of addition of l-glutamine to tpn on gut nitrogen content, histology, and disaccharidase enzyme activity. five groups of six fisher 344 rats received rat chow, d5w, tpn (23% calories as lipid), or tpn with 1 or 2% l-glutamine. animals given tpn received 30 kcal and 0.22 g nitrogen/100 g/day. metabolic cages al ...	1988	3131588
biliary secretory iga levels in rats with protein-calorie malnutrition.	malnutrition is a recognized cause of failure of host defense mechanisms. in the past 5 years, it has been demonstrated that the gut, long known to have significant morphologic changes with protein calorie malnutrition (pcm), is an immune organ affected by malnutrition. to assess the role of biliary immunoglobulin a (s-iga), part of the barrier to bacterial invasion from the gastrointestinal tract, the following study was performed. seventy-eight fisher female inbred rats weighing 110-130 g were ...	1988	3132112
comparison of stainless steel penicylinders used in disinfectant testing.	two brands of stainless steel penicylinders, s&l metal products and fisher scientific, were simultaneously tested to determine if they provide comparable results when used in the aoac use-dilution method of disinfectant testing. results showed consistently more positive tubes for the fisher brand of penicylinders than for the s&l, regardless of the surface finish of the test cylinders.	1988	3133351
some aspects of the diagnosis of specific vaginal infections in the rotterdam std clinic population.	we studied specific vaginal infections in 351 consecutive women who visited the rotterdam std clinic. prostitutes less often had vaginal or vulvar complaints than non-prostitutes (fisher test, p less than 0.01), but more often had abnormal discharge (fisher test, p less than 0.001). normal secretions were found in 52% of the women. clue cell-positive discharge (ccpd) was by far the most prevalent vaginal disease entity (32%). the wet mount showed pseudo-hyphae in 14 women (4%) and trichomonas va ...	1988	3134262
the influence of tobramycin dosage regimens on nephrotoxicity, ototoxicity, and antibacterial efficacy in a rat model of subcutaneous abscess.	the influence of dosage regimen on the nephrotoxicity, ototoxicity, and antibacterial efficacy of tobramycin was assessed in fisher rats with pseudomonas aeruginosa subcutaneous abscesses. a subcutaneous tobramycin dose of 10 mg/kg every 4 h resulted in peak and trough serum concentrations that approximated those currently recommended for patients. subsequently, the influence of this subcutaneous dosage regimen was compared with three other regimens that administered the same total daily dose: 2 ...	1988	3134490
tumor localization of newly developed hematoporphyrin (dhp) using a bladder tumor model: a novel hematoporphyrin derivative.	application of laser irradiation with porphyrin(s) or their derivatives for the destruction of tumors in humans requires preliminary studies of their localization in normal and malignant tissues. a novel derivative of hematoporphyrin (hp) was prepared. the newly developed hematoporphyrin (dhp) was administered to fisher rats with bladder tumors and showed greater accumulation in the tumoral tissues. comparative data on (hp) and (dhp) are presented and discussed in light of the enhanced tumor por ...	1988	3134948
human monoclonal antibodies that protect mice against challenge with pseudomonas aeruginosa.	lymphocytes from healthy volunteers and from cystic fibrosis patients were transformed with epstein-barr virus and cultured at a limiting dilution to generate lymphoblastoid cell lines that secreted human monoclonal antibodies specific for lipopolysaccharide (lps) from pseudomonas aeruginosa. three cell lines (rm5, fdd7, and 11f9) produced immunoglobulin m (igm) antibody species that reacted specifically with p. aeruginosa fisher immunotypes 2, 4, and 5, respectively, and with lps extracted from ...	1988	3135264
structure of an extracellular cross-reactive polysaccharide from pseudomonas aeruginosa immunotype 4.	a neutral small molecular mass (approximately 6.5 kda) polysaccharide comprising a pentasaccharide repeat unit was isolated from culture supernatants of pseudomonas aeruginosa immunotype 4. the polysaccharide had a pentasaccharide repeating unit as follows (formula; see text) where rha is rhamnose. the structure was determined using acid hydrolysis, solvolysis with anhydrous hydrogen fluoride, methylation analysis, and 1h and 13c nuclear magnetic resonance spectroscopy including nuclear overhaus ...	1988	3136157
apomorphine doses impair the reaction time of fast reacting but not slow reacting rats.	previously, several studies in our laboratories have linked the ability to initiate movement rapidly (reactive capacity) in several rat strains to markers of nigrostriatal dopamine function. in the present investigation we wished to determine the extent to which fast-reacting (fr) and slow-reacting (sr) rats responded differentially to the effects of dopamine agonist (apomorphine) administration. fisher 344 rats were operantly conditioned on a shock-avoidance, reactive capacity task which requir ...	1988	3137611
effect of chronic aurothioglucose treatment of rats on kidney catalase and cytochromes.	catalase activity and cytochrome content were measured in kidneys of fisher 344 rats injected with aurothioglucose (atg) either daily for 3 days or 5 days a week for up to 8 wk. catalase activity was decreased 39%, 59%, and 48% (all p less than 0.001) after 3 days, 2 wk, and 8 wk, respectively. microsomal cytochrome p-450 levels decreased 71%, 86%, and 80% (all p less than 0.001) after 3 days, 2 wk, and 8 wk, respectively. in contrast, cytochrome b5 was significantly increased at 3 days and 2 wk ...	1988	3138383
mechanisms of reduction of tumor recurrence with carbon dioxide laser in experimental mammary tumors.	this study compares local tumor recurrence after low energy co2 laser wound sterilization with recurrence after scalpel, laser or electrocautery excision. wound histologic changes were studied to understand the mechanism of the interaction between the laser and wound. single implants of r3230ac mammary tumor were grown to an average diameter of 24 millimeters in the mammary ridge of 80 female fisher 344 rats. rats were anesthesized with pentobarbital and randomized into groups, each with similar ...	1988	3142066
lambda phage cro repressor interaction with its operator dna: 2'-deoxy-5-fluorouracil or3 analogues.	the experiments here show that chemically synthesized dna containing fluorine at selected sites can be used to test specific predictions of a model for cro repressor--operator interaction. this is done by observation of the perturbation to the fluorine-19 nmr spectra of analogues of or3 synthesized with 2'-deoxy-5-fluorouracil at specific positions in the dna helix. although the three-dimensional structure of the cro repressor from phage lambda has been determined by matthews and co-workers [and ...	1985	3157402
the autologous mixed lymphocyte reaction is decreased in freund's adjuvant-injected rats of arthritis-susceptible and -insusceptible strains.	we examined the t-non-t cell autologous mixed lymphocyte reaction (amlr) of spleen cells from rats with arthritis induced by freund's complete adjuvant in an effort to establish an animal model for the study of the relationship between the amlr and autoimmune disease. we found that the splenic t-non-t amlr was markedly decreased in rats with adjuvant-induced arthritis and that this decrease was mediated by suppressor cells within the nylon-wool-adherent stimulator cell population. however, we al ...	1985	3159391
identification of the transformation-associated cell surface antigen expressed on the rat fetus-derived fibroblast.	a wka rat fetus-derived fibroblast cell line wfb showed strict nontransformant phenotypes in vitro such as anchorage dependency of cell growth in soft agar, contact inhibition, and serum dependency on the monolayer cell culture. transfection of 6.6-kilobase ejras oncogene into wfb resulted in the acquisition of tumorigenicity in vitro and in vivo. the cell surface antigen that is moderately or highly expressed on these wfb transformants, designated as w14 and w31, was analyzed using monoclonal a ...	1988	3162824
amino acid profiles in tumor-bearing and pair-fed nontumor-bearing malnourished rats.	to investigate the metabolic and organ changes accompanying growth of a malignant tumor, ten male fisher 344 rats weighing 150 to 200 g were inoculated subcutaneously with 10(6) viable mca sarcoma cells (tumor-bearing). ten other rats (controls) were similarly inoculated with saline. both groups were allowed food and water ad libitum. an additional ten rats (pair-fed) were inoculated with saline and fed the same mean daily food intake as the tumor-bearing rats. thirty-five days after inoculation ...	1988	3167766
miller fisher syndrome: an electrophysiologic case study.		1988	3168912
bile salt-dependent, neutral cholesteryl ester hydrolase of rat liver: possible relationship with pancreatic cholesteryl ester hydrolase.	homogenates of the livers of outbred, sprague-dawley rats contain a neutral cholesteryl ester hydrolase activity that requires millimolar concentrations of bile salts for maximal activity. previous studies showed that this activity had the unusual property of being highly variable among individual rats. the present studies were conducted to define further the nature of this enzymic activity and to explore the possible basis for the variability. individual liver homogenates from inbred fisher-344 ...	1988	3179327
synthesis and kinetics of decomposition of 7-(2-cyanoethyl)guanine and o6-(2-cyanoethyl)guanine, markers for reaction of acrylonitrile and 3-(methylnitrosamino)propionitrile with dna.	acrylonitrile, a carcinogen in rodents, is used in the large-scale production of acrylic polymers. 3-(methylnitrosamino)propionitrile, a potent carcinogen in fisher rats, is an areca-derived nitrosamine which has been found in the saliva of betel quid chewers. upon metabolic activation, both of these carcinogens can react with dna to form 7-(2-cyanoethyl)guanine and o6-(2-cyanoethyl)guanine. the latter has never been described. we have therefore synthesized this derivative by reacting 2-(n-carbe ...	1988	3180348
[caffeine and eeg mapping: effects of visuo-spatial task in healthy volunteers].	a group of 10 subjects, normal volunteers (6 men, 4 women), mean age 27.2 years, right-handers, has been selected for a double-blind study of caffeine effects (400 mg per os) versus placebo. one week delay separated the two eeg sessions quantified by spectral analysis. during each session (16 eeg channels, common reference), each subject was recorded four times: 2.5 min, in eyes-closed condition, under diffuse attention, followed by 2.5 min, during a visuo-spatial task ("eyes open" condition: pr ...	1988	3185461
[vasospasm and ischemia in a series of 60 aneurysms treated quickly surgically].	sixty patients with ruptured cerebral aneurysms were operated during the first 3 days after the onset of bleeding. in all cases the following investigations were performed: before surgery and 10 days after surgery angiography and ctscan, two months later a control ctscan. the first ctscans have been classified according to the staging defined by fisher. vasospasms (vs) were assessed comparing the arteriographies before and after surgery and classified as narrow or moderate; ischemia were assesse ...	2011	3185846
influence of dietary vitamin e on the intermembrane transfer of alpha-tocopherol as mediated by an alpha-tocopherol binding protein.	the effect of dietary vitamin e on the intermembrane transfer of (3r)-alpha-tocopherol, a spontaneous process accelerated in the presence of an alpha-tocopherol binding protein (alpha tbp), was examined. the transfer activity of this cytosolic liver protein was assayed via in vitro transfer of (3r)-alpha-[3h]tocopherol (alpha[3h]t) from egg lecithin liposomes to human erythrocyte ghosts (eg). male fisher 344 rats (1 and 20 months old) were fed diets containing 0, 30, and 500 mg/kg vitamin e (dl- ...	1988	3186764
chronic tubulointerstitial nephritis and renal insufficiency associated with long-term "subtherapeutic" gentamicin.	to determine whether long-term "subtherapeutic" concentrations of aminoglycoside produce chronic tubulointerstitial nephropathy, fisher rats were given gentamicin, 20 mg/kg/day, for up to 6 months via indwelling osmotic infusion pumps. studies included renal histology, autoradiographic quantitation of renal cell tritiated thymidine uptake, renal function and renal cortical gentamicin assay. acute proximal tubular injury, without tubular necrosis, followed by recovery, occurred during the first m ...	1988	3193025
the probability of dizygosity of phenotypically concordant twins.	a basic element in the determination of the zygosity of a twin pair is the proportion of genotypically concordant pairs among the dizygotic pairs. two methods to derive this proportion are in common use: the first method requires a laborious enumeration of parental genotypic mating types, and the second method relies on a set of formulas, one for each of the possible combinations of genotypes of two full sibs. in this paper the relation between both methods is uncovered. the set of formulas of t ...	1988	3195583
the dynamic distribution of fluorescent analogues of actin and myosin in protrusions at the leading edge of migrating swiss 3t3 fibroblasts.	the formation of protrusions at the leading edge of the cell is an essential step in fibroblast locomotion. using fluorescent analogue cytochemistry, ratio imaging, multiple parameter analysis, and fluorescence photobleaching recovery, the distribution of actin and myosin was examined in the same protrusions at the leading edge of live, locomoting cells during wound-healing in vitro. we have previously defined two temporal stages of the formation of protrusions: (a) initial protrusion and (b) es ...	1988	3204122
intrathecal synthesis of immunosuppressive acidic protein (iap) in patients with multiple sclerosis and other inflammatory neurological diseases.	immunosuppressive acidic protein (iap), an immunosuppressive substance produced mainly by macrophages, has previously been shown to increase in the serum of patients with inflammatory neurological diseases. in this study we assayed the iap levels in cerebrospinal fluid (csf) by a passive hemagglutination-inhibition test. csf-iap levels increased significantly in patients with multiple sclerosis (ms) during both the active and inactive stages and in patients with guillain-barré syndrome (gbs) or ...	1988	3210023
boron-11 mri and mrs of intact animals infused with a boron neutron capture agent.	boron neutron capture therapy (bnct) depends on the delivery of boron-containing drugs to a targeted lesion. currently, the verification and quantification of in vivo boron content is a difficult problem. boron-11 spectroscopy was utilized to confirm the presence of a dimeric sulfhydryl dodecaborane bnct agent contained in an intact animal. spectroscopy experiments revealed that the decay time of transverse magnetization of the boron-11 spins was less than 1 ms which precluded the use of a 2dft ...	1988	3210959
the investigation of experimental brain tumours using 31p-mrs and 1h-mri.	in vivo 31p-magnetic resonance spectra (mrs) were obtained by the surface coil method from rat glioma, human glioblastoma, and human neuroblastoma inoculated subcutaneously in cd fisher rats and hamsters, and the effects of chemotherapy, photoradiation therapy, and radiofrequency hyperthermia as well as 60co-irradiation were evaluated by sequentially observing spectral changes. in the 31p-spectra of tumour tissue, the nucleoside triphosphate (ntp), phosphomonoesters (pme) peaks were high and the ...	1988	3213641
a case of miller fisher syndrome.		1988	3217336
coxsackie virus heart disease: 15 years after.	from 1969 to 1973, 68 patients were admitted to the 4th division of medicine of the brescia civil hospital with the diagnosis of viral myocarditis. the patients were divided into two groups according to the results of the coxsackie virus complement fixing antibodies test: group 1 (42 patients) with a fourfold or greater rising antibody titre; group 2 (26 patients) with a negative serum test. both groups were examined after a follow-up period of 15 years. ten patients from group 1 died. the diagn ...	1988	3229424
comparison of local tumor recurrence following excision with the co2 laser, nd:yag laser, and argon beam coagulator.	this study compares the incidence of local tumor recurrence following primary excision with the co2 laser, nd:yag laser (contact), argon beam coagulator, or electrocautery. one hundred eight fisher 344 rats with r3230ac mammary tumors (1.6 +/- 0.04 [sd] cm diameter) were used. all animals were randomized into groups of similar tumor size. in groups c and cs, excision was performed with a sharplan 1060 co2 laser (temoo, 25 w, continuous wave [cw], 0.2-mm spot size). wounds in group cs were "steri ...	1988	3230999
electrophysiologic study of fisher syndrome.	electrophysiologic studies were performed on a 6-year-old girl with fisher syndrome. we recorded several evoked potentials in this patient: visual evoked potentials, auditory brainstem responses, auditory evoked potentials, short-latency somatosensory evoked potentials, blink reflex elicited by photic stimuli (photo-evoked eyelid microvibration), blink reflex elicited by auditory stimuli (auditory evoked eyelid microvibration), and motor nerve conduction velocity. in our study, photo-evoked eyel ...	2006	3242533
effects of short-term dietary restriction on survival of mammary ascites tumor-bearing rats.	we studied the effects of short-term dietary restriction on the survival of 3-4-month-old tumor-free and tumor-bearing fisher rats. the diet-restricted food regimen consisted of alternate day ad libitum feeding followed by alternate day fasting. diet-unrestricted control rats were fed ad libitum daily. six tumor-free rats on the diet-restricted regimen compensated for the dietary restriction by an increase in food consumption during the alternate feeding days, and lost an average of only 2-3% of ...	1988	3245934
[correlation between nasopharyngeal carcinoma and hla in sichuan].	fifty three cases of nasopharyngeal carcinoma (npc) in sichuan and 212 normal individuals in our university were studied for their human leucocyte antigen(hla) typing by the standard nih microcytotoxicity test. a total of 135 antisera which could defined 44 specificities of hla-a, b and dr loci were used for this purpose. in this paper, bw46 and dr antigens for detecting npc patients is reported at home for the first time. the results showed that there existed a strong correlation between bw46 a ...	1988	3248481
hyperiodothyroninaemia of neonates, its significance for thermogenesis.	danowski et al. (1951) were probably the first who showed an increase of pbi in infants shortly after birth. later a number of investigators presented further evidence on the increased thyroid gland function in newborns. this condition named "neonatal thyroid hyperactivity" [fisher and oddie, 1964] was described also in animals. the available data indicate that all the newborn mammals till now studied, independently of the maturation stage of development they reach at birth, display some feature ...	1988	3257052
influence of epidermal growth factor on intestinal function in the rat: comparison of systemic infusion versus luminal perfusion.	epidermal growth factor may be a trophic substance for the small intestine. previous studies had not evaluated intestinal absorption after long-term continuous administration of epidermal growth factor or compared luminal perfusion with systemic infusion. epidermal growth factor (150 micrograms/kg/day) was continuously infused either systemically or luminally for 14 days into young adult fisher strain rats. luminal studies were performed by creating 10 cm thiry-vella loops. at the conclusion of ...	1988	3257656
immune regulation dysfunction in chronic persistent hepatitis.	the study included 19 children diagnosed clinically, biochemically, and by liver biopsy as having chronic persistent hepatitis. the following investigations were carried out: 1. detection of total t-lymphocytes, t-helper, and t-suppressor cells using monoclonal antibodies (okt3, okt4 and okt8); 2. determination of hla-a, b and dr antigens using the microcytotoxicity technique. the results were analysed in comparison with data from a normal control group. there are several important findings. fir ...	1988	3260846
enhancement of aldehyde dehydrogenase activity in human and rat hepatocyte cultures by 3-methylcholanthrene.	aldehyde dehydrogenase was measured in primary cultures of hepatocytes obtained with a two-step collagenase perfusion either from human hepatic tissue or from livers of fisher rats. basal enzyme activity declines gradually as a function of time in culture, but remains at all times higher when measured with propionaldehyde and nad (p/nad) than with benzaldehyde and nadp (b/nadp). treatment of the cultures with 2 microm of 3-methylcholanthrene for four days significantly increased the b-nadp activ ...	1986	3267450
preliminary reports on hyperbaric oxygen therapy in multiple sclerosis.	preliminary clinical examinations comprised 16 patients suffering from multiple sclerosis, the mean duration of the disease 9.33 years, of the manifestations at different stages of the development--evaluated on the basis of kurtzke scale. the patients were subjected exclusively to the treatment with oxygen hyperbary--all in all 25-30 exposures, with the intervals of 24 hours, under the o2 pressure of 2 ata. the qualification for the purposes of treatment and the classification of the symptoms pr ...	1988	3270584
re: fisher: safe margins for melanoma excision.		1986	3273090
five vs. ten days of therapy for acute otitis media.	in a double blind study 175 patients with acute otitis media were randomized into 2 treatment groups: 10 days of therapy with cefaclor or 5 days of therapy followed by 5 days of placebo. the dosage of cefaclor was 40 mg/kg/day administered orally in equally divided doses at 12-hour intervals. tympanocentesis before treatment yielded specimens that contained streptococcus pneumoniae or haemophilus influenzae or both in 55% of specimens. branhamella catarrhalis was isolated from 21% of specimens. ...	1988	3277153
inhibition of dunning tumor growth by melatonin.	injections of the pineal hormone melatonin reduced growth and increased doubling time of the r3327h dunning prostatic adenocarcinoma in the copenhagen x fisher rat. this occurred even though testosterone levels (50% of normal) were ostensibly high enough to maintain normal tumor growth. melatonin may act directly upon the conversion of testosterone to dihydrotestosterone to inhibit tumor growth. alternatively, a more complicated mechanism may be involved since studies on mcf breast cancer tissue ...	1988	3283381
the role of preoperative radionuclide ejection fraction in direct abdominal aortic aneurysm repair.	preoperative radionuclide ventriculography was performed in 60 patients to assess whether such testing could define those at increased risk after direct abdominal aortic aneurysm (aaa) repair. none of the patients had prophylactic coronary artery reconstruction to reduce the risk of aaa repair despite angina in 27% and previous myocardial infarction (mi) in 42%. the mean ejection fraction (ef) was 52% +/- 15% (range 14% to 78%). low ef (normal greater than 50%) was present in 40%, whereas ventri ...	2012	3294449
wheezing in infants: the response to epinephrine.	there is significant controversy about the role of bronchodilator therapy for wheezing in infants. a double-blind, randomized trial of subcutaneous epinephrine upsilon normal saline was conducted in children less than 24 months of age evaluated at yale-new haven hospital. respiratory assessments using a newly developed respiratory distress assessment instrument were made at baseline and 15 minutes after each of two injections. relief of respiratory distress was assessed using strict a priori cri ...	1987	3295741
expression and characterization of transforming growth factor alpha precursor protein in transfected mammalian cells.	analysis of a cdna clone derived from retrovirus-transformed rat fibroblasts has recently suggested that the mature 50-amino-acid form of transforming growth factor alpha (tgf alpha) is derived from a 159-amino-acid transmembrane precursor by proteolytic cleavage. to understand the processing of the tgf alpha precursor molecule in more detail, we have expressed this protein in baby hamster kidney (bhk) fibroblasts under control of the metal-ion-inducible metallothionein promoter and characterize ...	1987	3299049
laser-assisted end-to-side anastomosis.	the milliwatt co2 laser was used to anastomose rat carotid arteries in an end-to-side fashion, and this technique was compared to the standard suture technique. vessels were studied at two to six weeks. all anastomosis were patient and overall, there was a 78.6 percent rate of aneurysm formation in the laser cohort, compared with 7.1 percent with suture (p less than 0.001 fisher exact). vessels and aneurysm histology were similar to those previously reported for the end-to-end technique.	1987	3309274
reimplantation injury after lung transplantation in a rat model.	distant procurement of organs for transplantation requires satisfactory preservation to reduce injury during ischemia and the initial phase of reperfusion. we have studied the mechanism of reimplantation injury after unilateral lung transplantation in isogeneic fisher rats. the heart and lungs were removed en bloc from donor rats and preserved at 4 degrees c. after 5 hours the left lung was transplanted into a recipient. radiographic and histologic evidence of pulmonary edema in the transplanted ...	1987	3312534
national kidney foundation report on dialyzer reuse.	numerous organizations have presented their views previously on the reprocessing of hemodialyzers. these were well summarized by easterling (easterling, re: regulations and standards, in deane, wineman, bemis [eds]: guide to reprocessing of hemodialyzers. martinus nijhoff, 1986, pp 183-197). the publication of the recommended practice by the association for the advancement of medical instrumentation (aami) on the reprocessing of dialyzers, coupled with the announcement of the federal government ...	1988	3337095
the art of medicine: subjective measures as predictors of outcome in stroke and traumatic brain injury.	this study was designed to explore new ways of predicting the functional outcomes of stroke and brain injury patients. upon admission and initial assessment of functional performance, we used an on-line computer program to indicate the most important and subjective judgment items to set rehabilitation goals for patients. the functional performance and discharge outcomes of patients from an inpatient program were measured by using five nonmedical functional items from the patient evaluation confe ...	1988	3348715
clinically unsuspected cerebral infarction revealed by computed tomography scanning in late onset epilepsy.	the computed tomography (ct) scans of 132 patients with late onset epilepsy were compared with the ct scans of an age- and sex-matched control group. patients with neurologic symptoms in addition to epilepsy, patients with a definite antecedent cause for epilepsy, and patients with tumours on ct scanning were excluded. fifteen of the patients with epilepsy, as opposed to two of the controls, had infarcts on their ct scans (p = 0.003 fisher exact test, two-tailed). in nine of these patients only ...	2016	3349970
postirradiation alterations of neuronal chromatin structure.	previous work from our laboratory suggested that neuronal chromatin structure may be altered immediately after exposure to ionizing radiation. in the present study, whole brains of 4-month-old male fisher 344 rats were irradiated with a dose of 25 gy. the kinetics of restoring the chromatin structure to its unirradiated state was investigated in rat cerebellar neurons using three different approaches: (1) measurement of changes in the dna superhelical structure by the fluorescent halo assay, (2) ...	1988	3353510