Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| molecular analysis of 16s rrna genes identifies potentially periodontal pathogenic bacteria and archaea in the plaque of partially erupted third molars. | small subunit rrna sequencing and phylogenetic analysis were used to identify cultivable and uncultivable microorganisms present in the dental plaque of symptomatic and asymptomatic partially erupted third molars to determine the prevalence of putative periodontal pathogens in pericoronal sites. | 2012 | 22326171 |
| the relationship between turbidity of mouth-rinsed water and oral health status. | the purpose of this study was to examine the relationship between turbidity of mouth rinsed water and oral health status such as dental and periodontal conditions, oral hygiene status, flow rate of saliva and oral bacteria. | 2013 | 22339260 |
| [effect of periodontal surgery on the subgingival periodontal microbiota in artificial class iii furcation defects: an experimental study in monkeys]. | this study was to longitudinally evaluate the change of prevalence of five periodontal putative pathogens in the subgingival plaque of artificial class iii furcation defects at the three time-points, including before the establishment of furcation defects, before and 6 months after periodontal surgery. | 2012 | 22353894 |
| [relationship between the preterm low birth weight infant and the periodontal pathogen bacteria in maternal saliva]. | to investigate the possible relationship between the preterm and/or low birth weight (plbw) and three anaerobic microorganisms in saliva of their mothers, including porphyromonas gingivalis (pg), tannerella forsythia (tf), treponema denticola (td). | 2012 | 22353895 |
| effects of oil drops containing lactobacillus salivarius wb21 on periodontal health and oral microbiota producing volatile sulfur compounds. | the objective of this paper is to evaluate the effects of oil drops containing lactobacillus salivarius wb21 on periodontal health and oral microbiota producing volatile sulfur compounds (vscs). for this study, 42 subjects were randomly assigned to receive oil samples containing l. salivarius wb21 or a placebo for two weeks. oral assessment and saliva collection were performed on days 1 and 15. bacterial analysis was performed using the real-time polymerase chain reaction and terminal restrictio ... | 2012 | 22368259 |
| oral microbiota in swiss adolescents. | the purpose of the study was to determine the prevalence of different oral microbes in gingival plaque samples and in samples from the dorsum of the tongue in a swiss adolescent population. | 2013 | 22371122 |
| anaerobic and microaerophilic pathogens in the biofilm formation on voice prostheses: a pilot study. | voice rehabilitation with voice prostheses is a standard therapy in laryngectomized patients. biofilm formation on the surface of the voice prostheses causes device failure and requires frequent replacements. studies analyzing the biofilm of voice prostheses have mainly focused on aerobic bacteria. anaerobic bacteria as an integral part of the biofilms on voice prostheses have not been investigated yet. | 2012 | 22374743 |
| pdt in non-surgical treatment of periodontitis in hiv patients: a split-mouth, randomized clinical trial. | the aim of this study was to evaluate the clinical and microbiological effect of photodynamic therapy (pdt) in the non-surgical treatment of periodontitis in hiv patients. | 2012 | 22407618 |
| distribution of periodontopathic bacterial species in dogs and their owners. | presently, a large number of individuals consider their companion animals as family members and have close contact with them in daily life. the purpose of the present study was to analyze the distribution of periodontopathic bacterial species in oral specimens taken from dogs and their owners. | 2012 | 22417880 |
| microbial profiles of patients seeking treatment for periodontitis. influence of origin, smoking and age? | we assessed the potential influence of the origin, the smoking status and the age on subgingival microbial profiles of subjects seeking periodontal care in switzerland today. | 2012 | 22419513 |
| comparison of microbial changes in early redeveloping biofilms on natural teeth and dentures. | surfaces and fluids can affect oral bacterial colonization. the aim of this study is to compare redeveloping biofilms on natural teeth and dentures. | 2012 | 22443543 |
| quantification of subgingival bacterial pathogens at different stages of periodontal diseases. | anaerobic gram-negative oral bacteria such as treponema denticola, aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, tannerella forsythia, campylobacter rectus, and fusobacterium nucleatum are closely associated with periodontal diseases. we measured the relative population (bacterial levels) of these oral pathogens in subgingival tissues of patients at different stages of korean chronic periodontal diseases. we divided the individuals into those with chronic gingivitis (g), moder ... | 2012 | 22526568 |
| oral bacteria and yeasts in relationship to oral ulcerations in hematopoietic stem cell transplant recipients. | oral mucositis is a serious and debilitating side effect of conditioning regimens for hematopoietic stem cell transplant (hsct). through hsct, the homeostasis in the oral cavity is disrupted. the contribution of the oral microflora to mucositis remains to be clarified. the aim of our study was to investigate the relationship between yeasts, bacteria associated with periodontitis, and oral ulcerations in hsct recipients. | 2012 | 22531876 |
| serum antibodies to periodontal pathogens are a risk factor for alzheimer's disease. | chronic inflammation in periodontal disease has been suggested as a potential risk factor in alzheimer's disease (ad). the purpose of this study was to examine serum antibody levels to bacteria of periodontal disease in participants who eventually converted to ad compared with the antibody levels in control subjects. | 2012 | 22546352 |
| fusobacterium nucleatum and tannerella forsythia induce synergistic alveolar bone loss in a mouse periodontitis model. | tannerella forsythia is strongly associated with chronic periodontitis, an inflammatory disease of the tooth-supporting tissues, leading to tooth loss. fusobacterium nucleatum, an opportunistic pathogen, is thought to promote dental plaque formation by serving as a bridge bacterium between early- and late-colonizing species of the oral cavity. previous studies have shown that f. nucleatum species synergize with t. forsythia during biofilm formation and pathogenesis. in the present study, we show ... | 2012 | 22547549 |
| prevalence of fima genotypes of porphyromonas gingivalis and other periodontal bacteria in a spanish population with chronic periodontitis. | the aim of this study was to determine the prevalence of the different fima genotypes of porphyromonas gingivalis in adult spanish patients with chronic periodontitis, patients with gingivitis and periodontally healthy subjects, and the relationship between these genotypes and other periodontopathogenic bacteria. | 2012 | 22549664 |
| subgingival microbial profiles as diagnostic markers of destructive periodontal diseases: a clinical epidemiology study. | to describe the subgingival microbial profiles of the major putative periodontal pathogens and investigate their role as diagnostic markers for destructive periodontal diseases in an untreated and isolated population. | 2013 | 22564019 |
| quantification of cultivable bacteria and endotoxin in post-treatment apical periodontitis before and after chemo-mechanical preparation. | this clinical study was conducted to quantify cultivable bacteria and endotoxin in root canals with post-treatment apical periodontitis by correlating their levels with clinical features and to evaluate the effect of chemo-mechanical preparation (cmp) with 2 % chlorhexidine gel + 17 % edta on bacterial and endotoxin removal/elimination. moreover, target strict gram-negative anaerobic bacteria were investigated by polymerase chain reaction (pcr). fifteen teeth with post-treatment apical periodont ... | 2012 | 22565224 |
| effect of azithromycin, as an adjunct to nonsurgical periodontal treatment, on microbiological parameters and gingival crevicular fluid biomarkers in generalized aggressive periodontitis. | emingil g, han b, özdemir g, tervahartiala t, vural c, atilla g, baylas h, sorsa t. the effect of azithromycin, as an adjunct to nonsurgical periodontal treatment, on microbiological parameters and gingival crevicular fluid biomarkers in generalized aggressive periodontitis. j periodont res 2012; 47: 729-739. © 2012 john wiley & sons a/s background and objective: to study the effectiveness of azithromycin in combination with nonsurgical periodontal therapy on clinical and microbiological parame ... | 2012 | 22571226 |
| the short-term treatment effects on the microbiota at the dorsum of the tongue in intra-oral halitosis patients--a randomized clinical trial. | this study aims to assess the effects of rinsing with zinc- and chlorhexidine-containing mouth rinse with or without adjunct tongue scraping on volatile sulfur compounds (vscs) in breath air, and the microbiota at the dorsum of the tongue. | 2013 | 22573244 |
| effects of systemic sitafloxacin on periodontal infection control in elderly patients. | to evaluate the microbiological and clinical effects of the systemic administration of sitafloxacin (stfx) on periodontal pockets in elderly patients receiving supportive periodontal therapy (spt). | 2012 | 22616908 |
| autoinducer 2 of fusobacterium nucleatum as a target molecule to inhibit biofilm formation of periodontopathogens. | periodontitis is initiated by bacteria in subgingival biofilms, which are composed mostly of gram-negative anaerobes. autoinducer 2 (ai-2) is a universal quorum sensing (qs) molecule that mediates intergeneric signalling in multispecies bacterial communities and may induce biofilm formation. as fusobacterium nucleatum is the major coaggregation bridge organism that links early colonising commensals and late pathogenic colonisers in dental biofilms via the accretion of periodontopathogens, we hyp ... | 2013 | 22633049 |
| does periodontopathic bacterial infection contribute to the etiopathogenesis of the autoimmune disease rheumatoid arthritis? | there is a significant association between rheumatoid arthritis (ra) and periodontal disease (pd). patients with longstanding active ra have been found to have a substantially increased frequency of pd compared with healthy subjects. further, patients with pd have been shown to have a higher prevalence of ra than patients without periodontitis. antibodies to gram-negative, anaerobic periodontal pathogens such as porphyromonas gingivalis, prevotella intermedia, prevotella melaninogenica, and tann ... | 2012 | 22642916 |
| relationship between the pathogenic representatives of periodontal pockets microbiocenosis in patients with periodontitis with varying degrees of severity. | periodontitis is a common disease that is considered to be a manifestation of the distortion of the ratio between the normal and conditionally pathogenic microflora of periodontal pockets. in this study, the ratio between the six most important periodontal pathogens and the total microflora of the periodontal pocket in healthy individuals and patients with varying severity of periodontitis was ascertained by quantitative real-time pcr. it was ascertained that the relative content ofporphyromonas ... | 2011 | 22649688 |
| co-localized or randomly distributed? pair cross correlation of in vivo grown subgingival biofilm bacteria quantified by digital image analysis. | the polymicrobial nature of periodontal diseases is reflected by the diversity of phylotypes detected in subgingival plaque and the finding that consortia of suspected pathogens rather than single species are associated with disease development. a number of these microorganisms have been demonstrated in vitro to interact and enhance biofilm integration, survival or even pathogenic features. to examine the in vivo relevance of these proposed interactions, we extended the spatial arrangement analy ... | 2012 | 22655057 |
| peripheral arterial disease associated with caries and periodontal disease. | peripheral arterial disease (pad) is an important cardiovascular disorder of the peripheral arteries. chronic infections, such as periodontitis, may play an important role in the etiology and pathophysiology of pad and other cardiovascular conditions. recently, streptococcus mutans has been found with high frequency in atheromatous plaques. the aim of this study is to evaluate the possible clinical and microbiologic association between pad and periodontitis and dental caries. | 2013 | 22680302 |
| identification of a unique tlr2-interacting peptide motif in a microbial leucine-rich repeat protein. | pathogenesis of many bacterially-induced inflammatory diseases is driven by toll-like receptor (tlr) mediated immune responses following recognition of bacterial factors by different tlrs. periodontitis is a chronic inflammation of the tooth supporting apparatus often leading to tooth loss, and is caused by a gram-negative bacterial consortium that includes tannerella forsythia. this bacterium expresses a virulence factor, the bspa, which drives periodontal inflammation by activating tlr2. the n ... | 2012 | 22695115 |
| a microbiological profile of unexposed and exposed pulp space of primary endodontic infections by checkerboard dna-dna hybridization. | the aim of this study was to evaluate, by checkerboard dna-dna hybridization, the composition of the microbiota of primary endodontic infections in cases associated with exposed (n = 30) and unexposed (n = 30) pulp space. | 2012 | 22703649 |
| a common periodontal pathogen has an adverse association with both acute and stable coronary artery disease. | the aim of this study was to investigate the association between angiographically verified coronary artery disease (cad) and salivary levels of four major periodontal pathogens. | 2012 | 22704805 |
| clinical, radiographic, microbiological, and immunological outcomes of flapped vs. flapless dental implants: a prospective randomized controlled clinical trial. | the objective of this study was to compare the placement of flapped vs. flapless dental implants utilizing clinical, radiographic, microbiological, and immunological parameters. | 2013 | 22708917 |
| subgingival microbiota from cebus apella (capuchin monkey) with different periodontal conditions. | this present study evaluated the subgingival microbiota of the cebus apella with different periodontal conditions kept by the tufted capuchin monkey procreation center (são paulo state university - unesp) or free-ranging monkeys. for this purpose, clinical specimens of subgingival biofilm were collected from 52 monkeys, of both genders, 40 kept in captivity and 12 free-ranging monkeys. the primates were submitted to periodontal evaluation and biofilm samples were transferred to vmga iii transpor ... | 2012 | 22710412 |
| [amalgam, composite and compomer: microbiological study]. | restorative materials have different consequences on the periodontium. the surface of these materials may influence gingival health and cause in some instances gingival inflammation. the purpose of this study was to investigate and compare, in a healthy periodontium, intracrevicular plaque bacteria (aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, prevotella intermedia, tannerella forsythensis and treponema denticola), at day 0 and at 6 months, around subgingivally located amalga ... | 2012 | 22715643 |
| clinical and microbiological parameters in patients with self-ligating and conventional brackets during early phase of orthodontic treatment. | to determine the effect of different bracket designs (conventional brackets and self-ligating brackets) on periodontal clinical parameters and periodontal pathogens in subgingival plaque. | 2013 | 22765511 |
| differential proteomic analysis of a polymicrobial biofilm. | porphyromonas gingivalis, treponema denticola, and tannerella forsythia exist in a polymicrobial biofilm associated with chronic periodontitis. the aim of this study was to culture these three species as a polymicrobial biofilm and to determine proteins important for bacterial interactions. in a flow cell all three species attached and grew as a biofilm; however, after 90 h of culture p. gingivalis and t. denticola were closely associated and dominated the polymicrobial biofilm. for comparison, ... | 2012 | 22808953 |
| periodontal pathogen load and increased antibody response to heat shock protein 60 in patients with cardiovascular disease. | to determine the relationship between periodontal pathogen load and anti-human heat shock protein 60 (hhsp60) antibodies in patients with established cardiovascular disease (cvd). | 2012 | 22882677 |
| long-term follow-up of turned single implants placed in periodontally healthy patients after 16 to 22 years: microbiologic outcome. | survival rates in implant dentistry today are high, although late failures do occur for many reasons, including peri-implant infections. the primary objective of this study is to investigate microbiota around single turned implants after 16 to 22 years. secondary objectives are to compare teeth and implants and to correlate microbiologic, radiographic, and clinical parameters. | 2013 | 22934839 |
| a bacterial glycan core linked to surface (s)-layer proteins modulates host immunity through th17 suppression. | tannerella forsythia is a pathogen implicated in periodontitis, an inflammatory disease of the tooth-supporting tissues often leading to tooth loss. this key periodontal pathogen is decorated with a unique glycan core o-glycosidically linked to the bacterium's proteinaceous surface (s)-layer lattice and other glycoproteins. herein, we show that the terminal motif of this glycan core acts to modulate dendritic cell effector functions to suppress t-helper (th)17 responses. in contrast to the wild- ... | 2012 | 22968422 |
| energy filtering transmission electron microscopy immunocytochemistry and antigen retrieval of surface layer proteins from tannerella forsythensis using microwave or autoclave heating with citraconic anhydride. | tannerella forsythensis (bacteroides forsythus), an anaerobic gram-negative species of bacteria that plays a role in the progression of periodontal disease, has a unique bacterial protein profile. it is characterized by two unique protein bands with molecular weights of more than 200 kda. it also is known to have a typical surface layer (s-layer) consisting of regularly arrayed subunits outside the outer membrane. we examined the relationship between high molecular weight proteins and the s-laye ... | 2012 | 22984898 |
| do elderly edentulous patients with a history of periodontitis harbor periodontal pathogens? | the presence of periodontal pathogens in the oral cavity may impact implant survival. therefore, this study aimed to determine the prevalence of campylobacter rectus, porphyromonas gingivalis, aggregatibacter actinomycetemcomitans, prevotella intermedia, tannerella forsythia, treponema denticola, eikenella corrodens, and parvimonas micra in a specific elderly population with a history of periodontitis who have never worn dentures. | 2012 | 22988660 |
| quantification of periodontopathic bacteria in saliva using the invader assay. | when quantifying periodontopathic bacteria, it is important to use a convenient method that does not produce false negative results. the invader assay is a convenient method because it does not involve gene amplification. the purpose of this study was to evaluate the validity of the invader assay to quantify periodontopathic bacteria. the invader technology was applied in quantifying five periodontopathic bacteria (aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, tannerella forsy ... | 2012 | 22996215 |
| a double-blind randomized placebo-controlled study on the clinical and microbial effects of an essential oil mouth rinse used by patients in supportive periodontal care. | this 3-month double-blind randomized placebo-controlled study evaluated the clinical and microbial effects of an essential oil mouth rinse used as an adjunct to mechanical plaque control by patients in supportive periodontal care. | 2013 | 22998386 |
| detection and enumeration of periodontopathogenic bacteria in subgingival biofilm of pregnant women. | the aim of this study was to use the fluorescence in situ hybridization (fish) technique to test the hypothesis of qualitative and quantitative differences of 8 periodontopathogens between pregnant and non-pregnant women. this cross-sectional study included 20 pregnant women in their second trimester of pregnancy and 20 non-pregnant women. probing depth, bleeding on probing, clinical attachment level, and presence of calculus were recorded. subgingival plaque samples were collected and the fish ... | 2012 | 23018230 |
| the sociodemographic characteristics, periodontal health status, and subgingival microbiota of patients with chronic periodontitis and type 2 diabetes mellitus: a case-control study in a chinese population. | in china, chronic periodontitis (cp) is common in patients with type 2 diabetes mellitus (t2dm). the purpose of this study is to identify the sociodemographic characteristics associated with such patients and to assess the periodontal health status and subgingival microbiota of patients with cp and t2dm (t2dmcp) in the chinese population. | 2013 | 23030242 |
| reduction of salivary arginine catabolic activity through periodontal therapy. | salivary enzymes may be used to diagnose periodontal conditions. salivary arginase activity (saa) is related to susceptibility to bacterial infection. therefore, the aim of this controlled interventional study was to determine the saa before and after non-surgical periodontal therapy. | 2012 | 23041992 |
| clinical and microbiological changes after minimally invasive therapeutic approaches in intrabony defects: a 12-month follow-up. | this 12-month randomized, controlled trial evaluated the clinical effects and microbiological changes of minimally invasive nonsurgical and surgical approaches for the therapy of intrabony defects. | 2013 | 23053707 |
| modeling susceptibility to periodontitis. | chronic inflammatory diseases like periodontitis have a complex pathogenesis and a multifactorial etiology, involving complex interactions between multiple genetic loci and infectious agents. we aimed to investigate the influence of genetic polymorphisms and bacteria on chronic periodontitis risk. we determined the prevalence of 12 single-nucleotide polymorphisms (snps) in immune response candidate genes and 7 bacterial species of potential relevance to periodontitis etiology, in chronic periodo ... | 2013 | 23100272 |
| prediction of periodontopathic bacteria in dental plaque of periodontal healthy subjects by measurement of volatile sulfur compounds in mouth air. | the aim of this study was to determine whether measurements of volatile sulfur compounds (vscs) are useful to predict colonization of periodontopathic bacteria. for this purpose, we assessed the relationships among distributions of 4 species of periodontopathic bacteria in tongue coating and dental plaque, oral conditions including vsc concentration in mouth air, and smoking habit of periodontal healthy young subjects. | 2013 | 23107050 |
| cleavage of igg1 in gingival crevicular fluid is associated with the presence of porphyromonas gingivalis. | immunoglobulin (ig) g1 plays an important role in the adaptive immune response. kgp, a lysine-specific cysteine protease from porphyromonas gingivalis, specifically hydrolyses igg1 heavy chains. the purpose of this study was to examine whether cleavage of igg1 occurs in gingival crevicular fluid (gcf) in vivo, and whether there is any association with the presence of porphyromonas gingivalis and other periodontopathogens. | 2012 | 23116446 |
| a phage display selected 7-mer peptide inhibitor of the tannerella forsythia metalloprotease-like enzyme karilysin can be truncated to ser-trp-phe-pro. | tannerella forsythia is a gram-negative bacteria, which is strongly associated with the development of periodontal disease. karilysin is a newly identified metalloprotease-like enzyme, that is secreted from t. forsythia. karilysin modulates the host immune response and is therefore considered a likely drug target. in this study peptides were selected towards the catalytic domain from karilysin (kly18) by phage display. the peptides were linear with low micromolar binding affinities. the two best ... | 2012 | 23119051 |
| boric acid irrigation as an adjunct to mechanical periodontal therapy in patients with chronic periodontitis: a randomized clinical trial. | the purpose of this single-masked, randomized, controlled clinical trial was to evaluate the effects of boric acid irrigation as an adjunct to scaling and root planing (srp) on clinical and microbiologic parameters and compare this method with chlorhexidine irrigation and srp alone in patients with chronic periodontitis (cp). | 2013 | 23121460 |
| possible translocation of periodontal pathogens into the lymph nodes draining the oral cavity. | numerous publications have reported the presence of periodontopathogenic bacteria in peripheral and central vascular lesions. however, it is unclear how this bacterial translocation occurs. the objective of this study was to investigate whether periodontopathic bacteria are translocated to lymph nodes proximal to the oral cavity. obtaining lymph node samples is not ethically feasible unless they are excised as part of the surgical management of patients with cancer. this study analyzed formalin- ... | 2012 | 23124752 |
| frequency of periodontal pathogens in equivalent peri-implant and periodontal clinical statuses. | this study tested the hypotheses that there is: (1) higher bacterial frequency in peri-implantitis/periodontitis, followed by mucositis/gingivitis and peri-implant/periodontal health; (2) similar bacterial frequency between comparable peri-implant and periodontal clinical statuses. | 2013 | 23127822 |
| screening for periodontopathogenic bacteria in severe chronic periodontitis in a moroccan population. | bacteria play an important role in destructive periodontitis. the aim of this study was to screen for five highly pathogenic bacteria: aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, prevotella intermedia, tannerella forsythia, and treponema denticola, in moroccan patients presenting with severe chronic periodontitis and to compare results with those of patients presenting with severe aggressive periodontitis. | 2012 | 23141872 |
| protective effect of topical cordia verbenacea in a rat periodontitis model: immune-inflammatory, antibacterial and morphometric assays. | this study evaluated the effects of c. verbenacea essential oil topically administered in a rat periodontitis model. | 2012 | 23171319 |
| influence of periodontal status and periodontopathogens on levels of oral human β-defensin-2 in saliva. | expression patterns of human β-defensin-2 (hbd-2) mrna or hbd-2 protein concentration and periodontal diseases have been a focus of scientific research. this study compares the salivary levels of hbd-2 protein concentration of healthy patients and patients with gingivitis and chronic periodontitis (cp) and correlates these levels with the presence of periodontopathogens. | 2013 | 23173827 |
| "cross-glycosylation" of proteins in bacteroidales species. | while it is now evident that the two bacteroidales species bacteroides fragilis and tannerella forsythia both have general o-glycosylation systems and share a common glycosylation sequon, the ability of these organisms to glycosylate a protein native to the other organism has not yet been demonstrated. here, we report on the glycosylation of heterologous proteins between these two organisms. using genetic tools previously developed for bacteroides species, two b. fragilis model glycoproteins wer ... | 2012 | 23258847 |
| bana-positive plaque samples are associated with oral hygiene practices and not cd4+ t cell counts in hiv-positive patients. | background. the "red complex" microorganisms, namely, porphyromonas gingivalis, treponema denticola, and tannerella forsythia are considered as potential pathogens causing hiv-associated periodontal diseases. moreover, it has been recognized that an association exists between cd4+ t cell counts and periodontal disease progression. objective. to establish whether cd4+ t cell counts or oral hygiene plays a greater role in producing bana-positive results in hiv-associated periodontal disease. mater ... | 2012 | 23258979 |
| validation of a quantitative real-time pcr assay and comparison with fluorescence microscopy and selective agar plate counting for species-specific quantification of an in vitro subgingival biofilm model. | subgingival biofilms are the prime etiological factor of periodontal disease. owing to their complex polymicrobial nature, quantification of individual bacterial species within the biofilm for research and diagnostic purposes can be methodologically challenging. the aims of this study were to establish a quantitative real-time pcr (qpcr) assay to quantify the bacteria used in our 10-species in vitro 'subgingival' biofilm model and to compare the quantitative outcome with fluorescence microscopy ... | 2012 | 23278531 |
| the influence of oral bacteria on tissue levels of toll-like receptor and cytokine mrnas in feline chronic gingivostomatitis and oral health. | feline chronic gingivostomatitis (fcgs) is an inflammatory disease of the oral cavity that causes severe pain and distress in affected cats. treatment methods are currently very limited. the aims of this study were to assess the feline innate immune response by investigating the levels of cytokine and toll-like receptor (tlr) mrnas in tissue biopsies of cats with and without fcgs, and to relate this to the presence or absence of putative oral pathogens identified previously within these cats. mu ... | 2012 | 23287555 |
| treponema denticola associates with increased levels of mmp-8 and mmp-9 in gingival crevicular fluid. | objectives: the aim was to assess the association between the presence of site-specific subgingival micro-organisms and the levels of matrix metalloproteinases-8 and matrix metalloproteinases-9 (mmp-8 and mmp-9) in gingival crevicular fluid (gcf). materials and methods: the patient group consisted of 56 subjects with periodontitis and the control group of 43 subjects without periodontitis. gcf samples from four test sites for each subject were collected. polymerase chain reaction was used to det ... | 2012 | 23294114 |
| [expression of cytokines in dentogingival sulcus in patients after dental implantation and during development of peri-implantitis]. | determination of cytokine content in various areas of dentition in patients with peri-implantitis associated with parodontopathogenic bacteria species of i and ii order. | 2012 | 23297645 |
| association between selected oral pathogens and gastric precancerous lesions. | we examined whether colonization of selected oral pathogens is associated with gastric precancerous lesions in a cross-sectional study. a total of 119 participants were included, of which 37 were cases of chronic atrophic gastritis, intestinal metaplasia, or dysplasia. an oral examination was performed to measure periodontal indices. plaque and saliva samples were tested with real-time quantitative pcr for dna levels of pathogens related to periodontal disease (porphyromonas gingivalis, tannerel ... | 2013 | 23308100 |
| suppuration-associated bacteria in patients with chronic and aggressive periodontitis. | suppuration (sup) on probing may be an indication of active periodontal breakdown. the aim of the present study is to analyze which subgingival species are associated with sup in patients with chronic (cp) and aggressive (agp) periodontitis. | 2013 | 23327648 |
| clinical and microbiological results following nonsurgical periodontal therapy with or without local administration of piperacillin/tazobactam. | we assessed if adjunct administration of piperacillin/tazobactam added clinical and microbiological treatment benefits. | 2013 | 23334268 |
| periodontal conditions during the pregnancy associated with periodontal pathogens. | to describe the bacterial associations in the periodontal pockets of pregnant women and to correlate the presence of prevotella intermedia, tannerella forsythia (t. forsythia), treponema denticola (t. denticola), aggregatibacter actinomycetemcomitans, and porphyromona gingivalis (p. gingivalis) with periodontal parameters of severity. | 2012 | 23335585 |
| the surface layer of tannerella forsythia contributes to serum resistance and oral bacterial coaggregation. | tannerella forsythia is an anaerobic, gram-negative bacterium involved in the so-called "red complex," which is associated with severe and chronic periodontitis. the surface layer (s-layer) of t. forsythia is composed of cell surface glycoproteins, such as tfsa and tfsb, and is known to play a role in adhesion/invasion and suppression of proinflammatory cytokine expression. here we investigated the association of this s-layer with serum resistance and coaggregation with other oral bacteria. the ... | 2013 | 23357386 |
| prevalence of periodontal pathogens and metabolic control of type 1 diabetes patients. | the aim of the study was to evaluate the prevalence of periodontal pathogens aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, prevotella intermedia, tannerella forsythia and treponema denticola in subgingival plaque collected at different probing depths of type 1 diabetes patients with periodontal disease in correlation to metabolic control. | 2013 | 23413629 |
| molecular mapping to species level of the tonsillar crypt microbiota associated with health and recurrent tonsillitis. | the human palatine tonsils, which belong to the central antigen handling sites of the mucosal immune system, are frequently affected by acute and recurrent infections. this study compared the microbiota of the tonsillar crypts in children and adults affected by recurrent tonsillitis with that of healthy adults and children with tonsillar hyperplasia. an in-depth 16s rrna gene based pyrosequencing approach combined with a novel strategy that included phylogenetic analysis and detection of species ... | 2013 | 23437130 |
| genetic analysis of porphyromonas gingivalis (fima), aggregatibacter actinomycetemcomitans, and red complex in coronary plaque. | the objective of the present study was to detect the presence of porphyromonas gingivalis (fima), aggregatibacter actinomycetemcomitans, and red complex in the coronary plaque of patients with coronary artery disease. | 2014 | 23447375 |
| polymicrobial infection with major periodontal pathogens induced periodontal disease and aortic atherosclerosis in hyperlipidemic apoe(null) mice. | periodontal disease (pd) and atherosclerosis are both polymicrobial and multifactorial and although observational studies supported the association, the causative relationship between these two diseases is not yet established. polymicrobial infection-induced periodontal disease is postulated to accelerate atherosclerotic plaque growth by enhancing atherosclerotic risk factors of orally infected apolipoprotein e deficient (apoe(null)) mice. at 16 weeks of infection, samples of blood, mandible, ma ... | 2013 | 23451182 |
| subgingival aggregatibacter actinomycetemcomitans associates with the risk of coronary artery disease. | we investigated the association between angiographically verified coronary artery disease (cad) and subgingival aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, tannerella forsythia and treponema denticola. | 2013 | 23521427 |
| cluster of bacteria associated with peri-implantitis. | information on the microbiota in peri-implantitis is limited. we hypothesized that neither gender nor a history of periodontitis/smoking or the microbiota at implants differ by implant status. | 2014 | 23527870 |
| mixed red-complex bacterial infection in periodontitis. | the red complex, which includes porphyromonas gingivalis, treponema denticola, and tannerella forsythia (formerly bacteroides forsythus), are recognized as the most important pathogens in adult periodontal disease. these bacteria are usually found together in periodontal pockets, suggesting that they may cause destruction of the periodontal tissue in a cooperative manner. this article discusses the interspecies pathogenic interactions within the red complex. | 2013 | 23533413 |
| detection of oral bacterial dna in synovial fluid. | as periodontal bacteria might be involved in the aetiology of rheumatic diseases, we analysed synovial fluid obtained from patients with rheumatoid arthritis (ra) and controls for the presence of dna of aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, prevotella intermedia, tannerella forsythia, and treponema denticola. | 2013 | 23534379 |
| modification of forsythia detaching factor by gingival crevicular fluid in periodontitis. | forsythia detaching factor (fdf) is a virulence factor of tannerella forsythia detected as a mixture of the 60-kda form of fdf and the 28-kda c-terminal fragment (fdfc). the objective of the present study was to clarify the proteolytic activity of gingival crevicular fluid (gcf) from patients with periodontitis and healthy subjects using recombinant fdf (rfdf) as substrate. | 2013 | 23538166 |
| anti-infective therapy of peri-implantitis with adjunctive local drug delivery or photodynamic therapy: 12-month outcomes of a randomized controlled clinical trial. | the objective of the study is to compare the clinical, microbiological and host-derived effects in the non-surgical treatment of initial peri-implantitis with either adjunctive local drug delivery (ldd) or adjunctive photodynamic therapy (pdt) after 12 months. | 2014 | 23560645 |
| prevalence of aggregatibacter actinomycetemcomitans, porphyromonas gingivalis and tannerella forsythia in japanese patients with generalized chronic and aggressive periodontitis. | this study aimed to investigate the prevalence and levels of major periodontal pathogens, aggregatibacter actinomycetemcomitans, porphyromonas gingivalis and tannerella forsythia in subgingival plaque samples of a group of japanese patients with aggressive periodontitis (agp) and chronic periodontitis (cp). a total of 40 patients with clinical diagnosis of agp or cp and 10 periodontally healthy volunteers were subjected to clinical and microbiological analysis. subgingival plaque samples were an ... | 2013 | 23608307 |
| structure and immunogenicity of the rough-type lipopolysaccharide from the periodontal pathogen tannerella forsythia. | tannerella forsythia is a gram-negative anaerobic organism that inhabits subgingival plaque biofilms and is covered with a so far unique surface layer composed of two glycoproteins. it belongs to the so-called "red complex" of bacteria comprising species that are associated with periodontal disease. while the surface layer glycoprotein glycan structure had been elucidated recently and found to be a virulence factor, no structural data on the lipopolysaccharide (lps) of this organism were availab ... | 2013 | 23616409 |
| evaluation of periodontal pathogens in amniotic fluid and the role of periodontal disease in pre-term birth and low birth weight. | pre-term birth and/or low birth weight (ptlbw) is a serious problem in developing countries. the absence of known risk factors in ≈ 50% of ptlbw cases has resulted in a continued search for other causes. the aim of this study was to examine the effect of periodontitis on pregnancy outcomes. | 2012 | 23638858 |
| detection of eight periodontal microorganisms and distribution of porphyromonas gingivalis fima genotypes in chinese patients with aggressive periodontitis. | the microbiologic feature of aggressive periodontitis (agp) in chinese patients has not yet been determined. this study aims to investigate the prevalence of eight periodontal microorganisms and the distribution of the porphyromonas gingivalis fima genotype in a cohort of chinese patients with agp. | 2014 | 23646850 |
| salivary carriage of periodontal pathogens in generalized aggressive periodontitis families. | generalized aggressive periodontitis (gap) is a multifactorial disease that shows a specific microbial profile and a familial aggregation. | 2014 | 23647376 |
| soluble triggering receptor expressed on myeloid cells 1 (strem-1) in gingival crevicular fluid: association with clinical and microbiologic parameters. | soluble triggering receptor expressed on myeloid cells 1 (strem-1) belongs to the immunoglobulin superfamily and is involved in amplification of the inflammatory response to bacterial infection. this cross-sectional study aims to investigate the levels of strem-1 in gingival crevicular fluid (gcf) of individuals without periodontitis and with chronic periodontitis (cp) or generalized aggressive periodontitis (gagp) and their association with the levels of key periodontal pathogens in subgingival ... | 2014 | 23659423 |
| association between il8 haplotypes and pathogen levels in chronic periodontitis. | chronic periodontitis (cp) is considered to be a multifactorial disease influenced by microbial and genetic factors. the aim of the present study was to investigate whether the genetic susceptibility to cp in individuals with the il8 atc/ttc haplotype is associated with subgingival levels of periodontopathogens. sixty-five individuals, grouped according to the presence (n = 28) or absence (n = 37) of the il8 haplotype, were evaluated. after clinical periodontal evaluation, each group was subdivi ... | 2013 | 23660697 |
| determining the presence of periodontopathic virulence factors in short-term postmortem alzheimer's disease brain tissue. | the aim of this study was to establish a link between periodontal disease and alzheimer's disease (ad) with a view to identifying the major periodontal disease bacteria (treponema denticola, tannerella forsythia, and porphyromonas gingivalis) and/or bacterial components in brain tissue from 12 h postmortem delay. our request matched 10 ad cases for tissue from brains for dementia research alongside 10 non-ad age-related controls with similar or greater postmortem interval. we exposed svgp12, an ... | 2013 | 23666172 |
| periodontopathogen and epstein-barr virus-associated periapical periodontitis may be the source of retrograde infectious peri-implantitis. | herpesviral-bacterial synergism may play a role in periodontitis and peri-implantitis etiopathogenesis. periapical periodontitis (pp) lesions can predict future apical peri-implantitis complications. | 2015 | 23675952 |
| structure of the catalytic domain of the tannerella forsythia matrix metallopeptidase karilysin in complex with a tetrapeptidic inhibitor. | karilysin is the only metallopeptidase identified as a virulence factor in the odontopathogen tannerella forsythia owing to its deleterious effect on the host immune response during bacterial infection. the very close structural and sequence-based similarity of its catalytic domain (kly18) to matrix metalloproteinases suggests that karilysin was acquired by horizontal gene transfer from an animal host. previous studies by phage display identified peptides with the consensus sequence xwfpxxxggg ( ... | 2013 | 23695557 |
| a randomized controlled clinical trial on the clinical and microbiological efficacy of systemic satranidazole in the treatment of chronic periodontitis. | the present clinical trial was designed to investigate the effectiveness of systemic satranidazole (sz) as an adjunct to scaling and root planing (srp) in the treatment of chronic periodontitis. | 2013 | 23705535 |
| effect of periodontal therapy on the subgingival microbiota over a 2-year monitoring period. i. overall effect and kinetics of change. | to examine the 2-year post-therapy kinetics of change in the composition of subgingival biofilms. | 2013 | 23710672 |
| porphyromonas gingivalis, treponema denticola and toll-like receptor 2 are associated with hypertensive disorders in placental tissue: a case-control study. | to explore the associations between the presence of periodontal pathogens and the expression of toll-like receptors (tlr-2 and tlr-4) in the placental tissue of patients with hypertensive disorders compared to the placentas of healthy normotensive patients. | 2013 | 23711357 |
| gingipain-dependent degradation of mammalian target of rapamycin pathway proteins by the periodontal pathogen porphyromonas gingivalis during invasion. | porphyromonas gingivalis and tannerella forsythia are gram-negative pathogens strongly associated with periodontitis. their abilities to interact, invade and persist within host cells are considered crucial to their pathogenicity, but the mechanisms by which they subvert host defences are not well understood. in this study, we set out to investigate whether p. gingivalis and t. forsythia directly target key signalling molecules that may modulate the host cell phenotype to favour invasion and per ... | 2013 | 23714361 |
| photodynamic therapy in the treatment of class ii furcation: a randomized controlled clinical trial. | to investigate the effect of photodynamic therapy (pdt) as adjunct to mechanical therapy in furcations. | 2013 | 23731242 |
| rheumatoid arthritis is an autoimmune disease caused by periodontal pathogens. | a statistically significant association between periodontal disease (pd) and systemic diseases has been identified. rheumatoid arthritis (ra), which is a chronic inflammatory joint disease, exhibits similar characteristics and pathogenesis to pd. the association between ra and pd has been investigated, and numerous publications on this subject exist. approximately 20 bacterial species have been identified as periodontal pathogens, and these organisms are linked to various types of pd. the most a ... | 2013 | 23737674 |
| reduction of two red complex bacteria by sustained-release doxycycline and correlation to improvement in mean pocket depth. | the objective was to evaluate the effects of an 8.5% sustained-release doxycycline-containing polymer formulation (srdf) on deep pockets (pocket depth [pd] ≥ 7 mm) in chronic periodontitis. total bacterial counts were used to estimate the number of viable bacteria present before treatment and for up to 6 months posttreatment. | 2011 | 23738858 |
| isolation of treponema and tannerella spp. from equine odontoclastic tooth resorption and hypercementosis related periodontal disease. | red complex bacteria, i.e. porphyromonas gingivalis, treponema denticola and tannerella forsythia, are involved in the onset and progression of periodontal disease in man, yet seldom inhabit the oral cavity of healthy individuals. periodontal disease is also encountered in horses, with equine odontoclastic tooth resorption and hypercementosis (eotrh) constituting a particular form of disease. however, only little is known about the oral microbiome of healthy and periodontitis-affected equids. | 2014 | 23742079 |
| periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis. | oral lichen planus (olp) is a chronic inflammatory disease that is frequently detected in oral tissues. the aim of our study was to identify the prevalence of the detection of periodontopathogenic microorganisms (aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, prevotella intermedia, tannerella forsythia and treponema denticola in olp patients and to compare with this prevalence of periodontopathogenic microorganisms in healthy non-olp patients. our study included 27 (18 chronic ... | 2013 | 23743616 |
| clinical evaluation of salivary periodontal pathogen levels by real-time polymerase chain reaction in patients before dental implant treatment. | periodontal pathogens in dental plaque are the main causative agents of periodontitis and peri-implantitis. detection of the presence of such periodontal pathogens early would serve as a useful tool in the diagnosis and treatment of this disease. therefore, the purpose of this study was to investigate whether the periodontal pathogen levels in saliva were correlated with the periodontal status of patients receiving implant treatment. | 2014 | 23745964 |
| clinical, microbiologic, and host response characteristics in patients with peri-implant mucositis. | to analyze the clinical, microbiologic, and host response characteristics (interleukins 1β and 6) in the peri-implant sulcus fluid (pisf) of patients with healthy dental implants and with peri-implant mucositis. | 2013 | 23748323 |
| periodontopathogens levels and clinical response to periodontal therapy in individuals with the interleukin-4 haplotype associated with susceptibility to chronic periodontitis. | periodontitis is an inflammatory disease that results from an interaction between dental biofilm agents and the host immune-inflammatory response. periodontopathogenic organisms, such as porphyromonas gingivalis, tannerella forsythia, and treponema denticola, as well as the host's susceptibility, represented by the host's genetic makeup, are the key factors that influence this complex disease. recently, we identified haplotypes in the il4 gene that were associated with chronic periodontitis (cp) ... | 2013 | 23748736 |
| [detection of periodontal pathogens from saliva of type 2 diabetic patients in urban area of beijing]. | to investigate the prevalence of periodontal pathogens from saliva of patients with type 2 diabetes mellitus (t2dm), and to characterize the association between the glucose status and periodontal pathogens in oral cavity. | 2013 | 23751528 |
| clinical and microbiologic effect of nonsurgical periodontal therapy on patients with chronic or aggressive periodontitis. | to evaluate the changes in the clinical parameters, and the prevalence and quantities of three major periodontopathic bacteria, namely porphyromonas gingivalis, aggregatibacter actinomycetemcomitans, and tannerella forsythia, in subgingival plaque collected from patients with generalized chronic periodontitis (gcp) or generalized aggressive periodontitis (gagp) in response to nonsurgical periodontal therapy. | 2013 | 23757461 |